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Information on EC 4.2.99.18 - DNA-(apurinic or apyrimidinic site) lyase and Organism(s) Saccharolobus solfataricus and UniProt Accession Q97ZK2

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EC Tree
     4 Lyases
         4.2 Carbon-oxygen lyases
             4.2.99 Other carbon-oxygen lyases
                4.2.99.18 DNA-(apurinic or apyrimidinic site) lyase
IUBMB Comments
'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under EC 3.1.25.2.
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Saccharolobus solfataricus
UNIPROT: Q97ZK2
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Word Map
The taxonomic range for the selected organisms is: Saccharolobus solfataricus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Synonyms
ap endonuclease, ref-1, ape1/ref-1, apex1, ape/ref-1, apurinic/apyrimidinic endonuclease 1, ap lyase, ape-1, alkbh1, endo iii, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AP 1
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AP Dnase
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AP endo
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AP endonuclease
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AP endonuclease Class I
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AP lyase
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AP-endonuclease
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Ape
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APEN
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APEX nuclease
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APN1
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apurinic DNA endonuclease
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apurinic endodeoxyribonuclease
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apurinic endonuclease
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apurinic-apyrimidinic DNA endonuclease
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apurinic-apyrimidinic endodeoxyribonuclease
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apurinic-apyrimidinic endonuclease
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apurinic/apyrimidinic lyase
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apurinic/apyrimidinic specific endonuclease
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apyrimidinic endonuclease
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class II apurinic/apyrimidinic(AP)-endonuclease
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deoxyribonuclease (apurinic or apyrimidinic)
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E. coli endonuclease III
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endodeoxyribonuclease
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endodeoxyribonuclease III
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endonuclease III
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endonuclease VI
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Escherichia coli endonuclease III
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HAP1
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HAP1h
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Micrococcus luteus UV endonuclease
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MMH
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Nfo
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Ntg1p
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Ntg2p
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NTH1
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nuclease, apurinic endodeoxyribo-
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nuclease, apurinic-apyrimidinic endodeoxyribo-
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nuclease, endodeoxyribo-, III
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phage-T4 UV endonuclease
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REF-1 protein
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Ref1
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UV endo V
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UV endonuclease
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UV endonuclease V
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SYSTEMATIC NAME
IUBMB Comments
DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase
'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. This group of enzymes was previously listed as endonucleases, under EC 3.1.25.2.
CAS REGISTRY NUMBER
COMMENTARY hide
60184-90-9
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61811-29-8
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