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EC Tree
IUBMB Comments The enzyme, characterized from the bacteria Actinosynnema mirum and Stigmatella aurantiaca DW4/3-1, produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.
The enzyme appears in viruses and cellular organisms
Synonyms
aroB , EVS,
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aroB
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EVS
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D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate
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-
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D-sedoheptulose-7-phosphate phosphate-lyase (cyclizing; 2-epi-valiolone-forming)
The enzyme, characterized from the bacteria Actinosynnema mirum and Stigmatella aurantiaca DW4/3-1, produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase.
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D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
-
2-epi-valiolone i.e. (2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexan-1-one
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?
D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
the enzyme produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis
-
-
?
D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
-
2-epi-valiolone i.e. (2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexan-1-one
-
?
D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
the enzyme produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis
-
-
?
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D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
the enzyme produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis
-
-
?
D-sedoheptulose 7-phosphate
2-epi-valiolone + phosphate
the enzyme produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis
-
-
?
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NAD+
the enzyme requires an NAD+ cofactor, which is transiently reduced during the reaction
NAD+
the enzyme requires an NAD+ cofactor, which is transiently reduced during the reaction
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Co2+
the enzyme requires a divalent metal ion (Zn2+ or Co2+)
Co2+
the enzyme requires a divalent metal ion (Zn2+ or Co2+)
Zn2+
the enzyme requires a divalent metal ion (Zn2+ or Co2+)
Zn2+
the enzyme requires a divalent metal ion (Zn2+ or Co2+)
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0.0386 - 0.0599
D-sedoheptulose 7-phosphate
0.0386
D-sedoheptulose 7-phosphate
pH 7.0, 28°C
0.0599
D-sedoheptulose 7-phosphate
pH 7.0, 28°C
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0.033 - 0.062
D-sedoheptulose 7-phosphate
0.033
D-sedoheptulose 7-phosphate
pH 7.0, 28°C
0.062
D-sedoheptulose 7-phosphate
pH 7.0, 28°C
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0.556 - 1.6
D-sedoheptulose 7-phosphate
0.556
D-sedoheptulose 7-phosphate
pH 7.0, 28°C
1.6
D-sedoheptulose 7-phosphate
pH 7.0, 28°C
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7
assay at
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28
assay at
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UniProt
brenda
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UniProt
brenda
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metabolism
the enzyme produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis
metabolism
the enzyme produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis
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EVS_ACTMD
Actinosynnema mirum (strain ATCC 29888 / DSM 43827 / NBRC 14064 / IMRU 3971)
382
0
41009
Swiss-Prot
-
EVS_STIAD
Stigmatella aurantiaca (strain DW4/3-1)
406
1
43439
Swiss-Prot
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A0A644UHP5_9ZZZZ
366
0
40863
TrEMBL
other Location (Reliability: 4 )
A0A645AWD6_9ZZZZ
136
0
15230
TrEMBL
other Location (Reliability: 1 )
A0A7Z3QD24_LACPN
359
0
38166
TrEMBL
-
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41009
x * 41009, calculated from sequence
43439
x * 43439, calculated from sequence
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?
x * 41009, calculated from sequence
?
x * 43439, calculated from sequence
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-
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expression in Escherichia coli
expression in Escherichia coli
expression in Escherichia coli
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Asamizu, S.; Xie, P.; Brumsted, C.J.; Flatt, P.M.; Mahmud, T.
Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products
J. Am. Chem. Soc.
134
12219-12229
2012
Actinosynnema mirum (C6WFL3), Stigmatella aurantiaca (Q08VU0)
brenda
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History
Enzyme Nomenclature
4.2.3.155 2-epi-valiolone synthase
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