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IUBMB CommentsA multifunctional enzyme which also forms (+)-β-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-β-caryophyllene synthase].
The expected taxonomic range for this enzyme is: Streptomyces griseus
Synonyms
(+)-caryolan-1-ol synthase, more
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EC 3.7.1.15
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GcoA
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(+)-beta-caryophyllene + H2O = (+)-caryolan-1-ol
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(+)-beta-caryophyllene hydrolase [cyclizing, (+)-caryolan-1-ol-forming]
A multifunctional enzyme which also forms (+)-beta-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-beta-caryophyllene synthase].
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(+)-beta-caryophyllene + H2O
(+)-caryolan-1-ol
(+)-beta-caryophyllene + H2O
(+)-caryolan-1-ol
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Substrates: -
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(+)-beta-caryophyllene + H2O
(+)-caryolan-1-ol
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Substrates: -
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Mg2+
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more than 5 mM MgCl2 is required for maximum activity. The enzyme reaction is unable to proceed without MgCl2
Mn2+
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38% activity (relative to the activity in the presence ofMg2+) is retained in the presence of 5 mM Mn2+
additional information
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no activity is observed for Fe2+, Co2+, Zn2+, Ni2+, or Cu2+
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brenda
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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GCOA_STRGG
Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350)
335
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37906
Swiss-Prot
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41000
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x * 41000, SDS-PAGE
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x * 41000, SDS-PAGE
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x * 41000, SDS-PAGE
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Ni-NTA column chromatography
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expressed in Streptomyces lividans strain TK21 and as N-terminally histidine-tagged enzyme in Escherichia coli BL21(DE3) cells
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Nakano, C.; Horinouchi, S.; Ohnishi, Y.
Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus
J. Biol. Chem.
286
27980-27987
2011
Streptomyces griseus, Streptomyces griseus IFO 13350
brenda
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