Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 4.2.1.111 - 1,5-anhydro-D-fructose dehydratase

for references in articles please use BRENDA:EC4.2.1.111

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

This enzyme catalyses one of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose [1,2]. The other enzymes involved in this pathway are EC 4.2.1.110 (aldos-2-ulose dehydratase), EC 4.2.2.13 [exo-(1→4)-α-D-glucan lyase] and EC 5.3.2.7 (ascopyrone tautomerase). Requires divalent (Ca2+ or Mg2+) or monovalent cations (Na+) for optimal activity. Unlike EC 4.2.1.110, aldos-2-ulose dehydratase, the enzyme is specific for 1,5-anhydro-D-fructose as substrate and shows no activity towards aldose-2-uloses such as 2-dehydroglucose [1,2,3]. In addition, it is inhibited by its end-product ascopyrone M and it cannot convert ascopyrone M into microthecin, as can EC 4.2.1.110.

The expected taxonomic range for this enzyme is: Pezizales

Synonyms
1,5-anhydro-D-arabino-hex-2-ulose dehydratase, 1,5-anhydro-D-fructose 4-dehydratase, 1,5-anhydro-D-fructose hydro-lyase, 1,5-anhydro-D-fructose hydrolyase, AF dehydratase, AFDH, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
1,5-anhydro-D-fructose = 1,5-anhydro-4-deoxy-D-glycero-hex-3-en-2-ulose + H2O
show the reaction diagram
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-
Highest Expressing Human Cell Lines
Cell Line Links Gene Links