Information on EC 4.1.1.66 - uracil-5-carboxylate decarboxylase

for references in articles please use BRENDA:EC4.1.1.66
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)


The expected taxonomic range for this enzyme is: Neurospora crassa

top print hide
EC NUMBER
COMMENTARY hide
4.1.1.66
-
top print hide
RECOMMENDED NAME
GeneOntology No.
uracil-5-carboxylate decarboxylase
top print hide
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
uracil 5-carboxylate = uracil + CO2
show the reaction diagram
-
-
-
-
top print hide
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
-
-
-
-
top print hide
SYSTEMATIC NAME
IUBMB Comments
uracil-5-carboxylate carboxy-lyase (uracil-forming)
-
top
top print hide
CAS REGISTRY NUMBER
COMMENTARY hide
59299-01-3
-
top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
top print hide
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Uracil-5-carboxylate
?
show the reaction diagram
-
enzyme is involved in thymidine metabolism
-
-
-
Uracil-5-carboxylate
Uracil + CO2
show the reaction diagram
top print hide
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
Uracil-5-carboxylate
?
show the reaction diagram
-
enzyme is involved in thymidine metabolism
-
-
-
top print hide
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
no cofactor requirement
-
top print hide
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
-
-
top print hide
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.2 - 10
-
activity reduced at pH 5.2 and 10.0
top print hide
PDB
SCOP
CATH
UNIPROT
ORGANISM
Cordyceps militaris (strain CM01);
E9F0X0
Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075);
top print hide
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
100
-
inactivation after 3 min
top print hide
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-30°C, overnight storage, 80% loss of activity
-
top print hide
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
top
top
top
LINKS TO OTHER DATABASES (specific for EC-Number 4.1.1.66)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)