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Information on EC 4.1.1.66 - uracil-5-carboxylate decarboxylase

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EC Tree

4 Lyases

4.1 Carbon-carbon lyases

4.1.1 Carboxy-lyases

4.1.1.66 uracil-5-carboxylate decarboxylase

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The expected taxonomic range for this enzyme is: Neurospora crassa

Reaction Schemes

Synonyms

Decarboxylase, uracil-5-carboxylate, uracil-5-carboxylic acid decarboxylase, show all synonyms

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SYNONYM

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

Decarboxylase, uracil-5-carboxylate

uracil-5-carboxylic acid decarboxylase

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REACTION

REACTION DIAGRAM

COMMENTARY

ORGANISM

UNIPROT

LITERATURE

uracil 5-carboxylate = uracil + CO2

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REACTION TYPE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

decarboxylation

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SYSTEMATIC NAME

IUBMB Comments

uracil-5-carboxylate carboxy-lyase (uracil-forming)

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CAS REGISTRY NUMBER

COMMENTARY

59299-01-3

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SUBSTRATE

PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

Uracil-5-carboxylate

Neurospora crassa

enzyme is involved in thymidine metabolism

4792

Uracil-5-carboxylate

Uracil + CO2

2 entries

Uracil-5-carboxylate

Uracil + CO2

Neurospora crassa

4792

Uracil-5-carboxylate

Uracil + CO2

Neurospora crassa

no evidence for reverse reaction

4793

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

Uracil-5-carboxylate

Neurospora crassa

enzyme is involved in thymidine metabolism

4792

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COFACTOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

additional information

Neurospora crassa

no cofactor requirement

4793

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SPECIFIC ACTIVITY [µmol/min/mg]

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

Neurospora crassa

4793

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pH RANGE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

5.2 - 10

Neurospora crassa

activity reduced at pH 5.2 and 10.0

4793

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ORGANISM

COMMENTARY

LITERATURE

UNIPROT

SEQUENCE DB

SOURCE

Neurospora crassa

4792, 4793

brenda

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UNIPROT

ENTRY NAME

ORGANISM

NO. OF AA

NO. OF TRANSM. HELICES

MOLECULAR WEIGHT[Da]

SOURCE

SEQUENCE

LOCALIZATION PREDICTION

The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).

Q66Q79 pBLAST

Q66Q79_NEUCS

Neurospora crassa

394

42935

TrEMBL

Show Sequence

other Location (Reliability: 2)

E9F0X0 pBLAST

E9F0X0_METRA

Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075)

377

41216

TrEMBL

Show Sequence

G3J531 pBLAST

G3J531_CORMM

Cordyceps militaris (strain CM01)

376

40676

TrEMBL

Show Sequence

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PDB

SCOP

CATH

UNIPROT

ORGANISM

3 entries

Cordyceps militaris

4hjw, download, 3D-view

SCOPe (4hjw)

CATH (4hjw)

E9F0X0

Metarhizium anisopliae

4hk5, download, 3D-view

4hk6, download, 3D-view

4hk7, download, 3D-view

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TEMPERATURE STABILITY

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

100

Neurospora crassa

inactivation after 3 min

4793

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STORAGE STABILITY

ORGANISM

UNIPROT

LITERATURE

-30°C, overnight storage, 80% loss of activity

Neurospora crassa

4793

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PURIFICATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

partial

Neurospora crassa

4793

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REF.

AUTHORS

TITLE

JOURNAL

VOL.

PAGES

YEAR

ORGANISM (UNIPROT)

PUBMED ID

SOURCE

4792

Griswold, W.R.; Madrid, V.O.; Shaffer, P.M.; Tappen, D.C.; Pugh, C.S.G.; Abbott, M.T.

Regulation of thymidine metabolism in Neurospora crassa

J. Bacteriol.

125

1040-1047

1976

Neurospora crassa

130374

brenda

4793

Palmatier, R.D.; McCroskey, R.P.; Abbott, M.T.

The enzymatic conversion of uracil 5-carboxylic acid to uracil and carbon dioxide

J. Biol. Chem.

245

6706-6710

1970

Neurospora crassa

5482775

brenda

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EXTERNAL LINKS (specific for EC-Number 4.1.1.66)

NCBI: PubMed, Protein, Nucleotide, Structure, Gene, OMIM

IUBMB Enzyme Nomenclature

UniProt

PDB

PROSITE Database of protein families and domains

InterPro (database of protein families, domains and functional sites)

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