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Information on EC 3.6.5.2 - small monomeric GTPase
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EC Tree
3.6.5.2 small monomeric GTPaseIUBMB Comments
A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
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Word Map
- 3.6.5.2
- actin
- oncogene
- cytoskeleton
- endosomes
- colorectal
- pancreatic
- metastasis
- endothelial
- adenocarcinoma
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gtp-bound
- tumorigenesis
- carcinogenesis
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endocytic
- integrins
- gdp
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gtpase-activating
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dominant-negative
- phosphatidylinositol
- mapk
- vesicular
- erk
- microtubule
- synaptic
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exocytosis
- filopodia
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cargo
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neurite
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traffic
- myosin
- 3-kinase
- guanosine
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cell-cell
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protrusion
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cytokinesis
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ruffle
- proto-oncogene
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farnesylation
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prenylation
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geranylgeranylation
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rock
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adhesions
- lamellipodia
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adherens
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pleckstrin
- raf
- aminoacyl-trnas
- melanosomes
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farnesyltransferase
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rho-associated
- actomyosin
- analysis
- drug development
- pharmacology
- medicine
The enzyme appears in viruses and cellular organisms
Synonyms
k-ras, cdc42, h-ras, small gtpase, ef-tu, rho gtpase, rab11, rab3a, rab27a, rap1a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
GTP-phosphohydrolase
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GTPase
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guanine triphosphatase
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guanosine 5'-triphosphatase
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guanosine triphosphatase
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ribosomal GTPase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phosphorous acid anhydride hydrolysis
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SYSTEMATIC NAME
IUBMB Comments
GTP phosphohydrolase (cell-regulating)
A family of about 50 enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase (EC 3.6.5.1). They are involved in cell-growth regulation (Ras subfamily), membrane vesicle traffic and uncoating (Rab and ARF subfamilies), nuclear protein import (Ran subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies).
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CAS REGISTRY NUMBER
COMMENTARY
9059-32-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
most RhoGTPases bind to chaperones, called guanine nucleotide dissociation inhibitors (RhoGDIs), which are cytosolic proteins that lack enzymatic activity. GDIs retain RhoGTPases in the inactive conformation, sequester them from cellular membranes and protect the GTPase from effector binding and proteolytic degradation
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additional information
most RhoGTPases bind to chaperones, called guanine nucleotide dissociation inhibitors (RhoGDIs), which are cytosolic proteins that lack enzymatic activity. GDIs retain RhoGTPases in the inactive conformation, sequester them from cellular membranes and protect the GTPase from effector binding and proteolytic degradation
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additional information
most RhoGTPases bind to chaperones, called guanine nucleotide dissociation inhibitors (RhoGDIs), which are cytosolic proteins that lack enzymatic activity. GDIs retain RhoGTPases in the inactive conformation, sequester them from cellular membranes and protect the GTPase from effector binding and proteolytic degradation
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aberrant Crypt Foci
Aberrant crypt foci and K-ras mutations: earliest recognized players or innocent bystanders in colon carcinogenesis?
Aberrant Crypt Foci
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
Aberrant Crypt Foci
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Aberrant Crypt Foci
Cell cycle variations in azoxymethane-induced rat colorectal carcinogenesis studied by flow cytometry.
Aberrant Crypt Foci
Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA -mediated real-time PCR clamping and mutant-specific probes.
Aberrant Crypt Foci
DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients.
Aberrant Crypt Foci
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
Aberrant Crypt Foci
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Aberrant Crypt Foci
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Aberrant Crypt Foci
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Aberrant Crypt Foci
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
Aberrant Crypt Foci
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
Aberrant Crypt Foci
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
Aberrant Crypt Foci
Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane.
Aberrant Crypt Foci
O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.
Aberrant Crypt Foci
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Aberrant Crypt Foci
Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxymethane in Fischer-344 rats on high-risk diet.
Aberrant Crypt Foci
Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons.
Aberrant Crypt Foci
Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.
Aberrant Crypt Foci
Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model.
Aberrant Crypt Foci
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Aberrant Crypt Foci
Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon.
Aberrant Crypt Foci
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Aberrant Crypt Foci
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
Abnormalities, Multiple
Cdc42 regulates cofilin during the establishment of neuronal polarity.
Abortion, Spontaneous
Instability at the H-ras minisatellite is associated with the spontaneous abortion of the embryo.
Acquired Immunodeficiency Syndrome
Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis.
Acquired Immunodeficiency Syndrome
Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.
Acquired Immunodeficiency Syndrome
Incidental Cystic Lesions in the Pancreas: Resect? EUS? Follow?
Acquired Immunodeficiency Syndrome
Spatial Distribution and Ribosome-Binding Dynamics of EF-P in Live Escherichia coli.
Acromegaly
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
Acute Lung Injury
Afadin controls p120-catenin - ZO-1 interactions leading to endothelial barrier enhancement by oxidized phospholipids.
Acute Lung Injury
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Adenocarcinoma
A case of pancreatic adenocarcinoma with novel K-ras mutation and long term survival.
Adenocarcinoma
A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells: Its evaluation by immunohistochemical and genetic analyses.
Adenocarcinoma
A Case Report of Long-Term Survival following Hepatic Arterial Infusion of L-Folinic Acid Modulated 5-Fluorouracil Combined with Intravenous Irinotecan and Cetuximab Followed by Hepatectomy in a Patient with Initially Unresectable Colorectal Liver Metastases.
Adenocarcinoma
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Adenocarcinoma
A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer: a Southwest oncology group (SWOG 9924) study.
Adenocarcinoma
A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.
Adenocarcinoma
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
Adenocarcinoma
A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis.
Adenocarcinoma
A two-step enriched-nested PCR technique enhances sensitivity for detection of codon 12 K-ras mutations in pancreatic adenocarcinoma.
Adenocarcinoma
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Adenocarcinoma
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.
Adenocarcinoma
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Adenocarcinoma
Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.
Adenocarcinoma
Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.
Adenocarcinoma
Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.
Adenocarcinoma
Additional K-ras mutation analysis and Plectin-1 staining improve the diagnostic accuracy of pancreatic solid mass in EUS-guided fine needle aspiration.
Adenocarcinoma
Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside.
Adenocarcinoma
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
Adenocarcinoma
Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases.
Adenocarcinoma
Administration of Chemotherapy by an Arteriovenous Fistula in a Patient with Metastatic Rectal Cancer after Life-Threatening, Port Thrombosis-Associated Cava Superior Syndrome. An Option for Patients without Possibility of Peripheral or Central Venous Access.
Adenocarcinoma
Allosteric modulation of Ras and the PI3K/AKT/mTOR pathway: emerging therapeutic opportunities.
Adenocarcinoma
Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado.
Adenocarcinoma
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Adenocarcinoma
Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium.
Adenocarcinoma
Altered detoxification status and increased resistance to oxidative stress by K-ras transformation.
Adenocarcinoma
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
Adenocarcinoma
An integrated approach for comparative proteomic analysis of human bile reveals overexpressed cancer-associated proteins in malignant biliary stenosis.
Adenocarcinoma
Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix.
Adenocarcinoma
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease.
Adenocarcinoma
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Adenocarcinoma
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Adenocarcinoma
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Adenocarcinoma
Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.
Adenocarcinoma
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Adenocarcinoma
Analysis of point mutations at codon 12 of K-ras in human endometrial carcinoma and cervical adenocarcinoma by dot blot hybridization and polymerase chain reaction.
Adenocarcinoma
Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
Adenocarcinoma
Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.
Adenocarcinoma
Angiogenesis and p53 and H-ras mutations in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.
Adenocarcinoma
Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
Adenocarcinoma
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Adenocarcinoma
Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
Adenocarcinoma
C-erbB-2 expression and codon 12 K-ras mutations both predict shortened survival for patients with pulmonary adenocarcinomas.
Adenocarcinoma
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
Adenocarcinoma
Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
Adenocarcinoma
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Adenocarcinoma
CDDO-Me inhibits tumor growth and prevents recurrence of pancreatic ductal adenocarcinoma.
Adenocarcinoma
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Adenocarcinoma
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Adenocarcinoma
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Adenocarcinoma
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
Adenocarcinoma
Circulating MicroRNAs in Serum of Human K-ras Oncogene Transgenic Rats With Pancreatic Ductal Adenocarcinomas.
Adenocarcinoma
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Adenocarcinoma
CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas.
Adenocarcinoma
Clinical application of K-ras oncogene mutations in pancreatic carcinoma: detection of micrometastases.
Adenocarcinoma
Clinical application of ras gene mutation for diagnosis of pancreatic adenocarcinoma.
Adenocarcinoma
Clinical impact of K-ras mutation analysis in EUS-guided FNA specimens from pancreatic masses.
Adenocarcinoma
Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma.
Adenocarcinoma
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Adenocarcinoma
Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.
Adenocarcinoma
Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia.
Adenocarcinoma
Clinicopathologic analysis of k-ras, p53, and ERBB-2 gene alterations in pulmonary adenocarcinoma.
Adenocarcinoma
Clinicopathologic evaluation of the trend toward histologically poor differentiation with submucosal invasion in superficial early colorectal adenocarcinomas.
Adenocarcinoma
Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation.
Adenocarcinoma
Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer.
Adenocarcinoma
Comparison of K-ras point mutation distributions in intraductal papillary-mucinous tumors and ductal adenocarcinoma of the pancreas.
Adenocarcinoma
Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.
Adenocarcinoma
Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients.
Adenocarcinoma
Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity.
Adenocarcinoma
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.
Adenocarcinoma
Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Adenocarcinoma
Cribriform adenocarcinoma of minor salivary glands may express galectin-3, cytokeratin 19, and HBME-1 and contains polymorphisms of RET and H-RAS proto-oncogenes.
Adenocarcinoma
CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
Adenocarcinoma
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
Adenocarcinoma
CYP1B1 Polymorphisms and K-ras Mutations in Patients with Pancreatic Ductal Adenocarcinoma.
Adenocarcinoma
Detection and clinical correlations of ras gene mutations in human ovarian tumors.
Adenocarcinoma
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Adenocarcinoma
Detection of extrapancreatic nerve plexus invasion of pancreatic adenocarcinoma. Cytokeratin 19 staining and K-ras mutation.
Adenocarcinoma
Detection of genetic abnormalities in neoplasms from Greek patients with FAP.
Adenocarcinoma
Detection of hepatic micrometastasis in pancreatic adenocarcinoma patients by two-stage polymerase chain reaction/restriction fragment length polymorphism analysis.
Adenocarcinoma
Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers.
Adenocarcinoma
Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.
Adenocarcinoma
Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.
Adenocarcinoma
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Adenocarcinoma
Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
Adenocarcinoma
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
Adenocarcinoma
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Adenocarcinoma
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Adenocarcinoma
Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT.
Adenocarcinoma
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Adenocarcinoma
Detection of multiple hepatic micrometastases in pancreatic adenocarcinoma with a solitary liver metastasis by direct sequencing of the K-ras gene: a case report.
Adenocarcinoma
Detection of mutant K-ras in dissected paraaortic lymph nodes of patients with pancreatic adenocarcinoma.
Adenocarcinoma
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Adenocarcinoma
Detection of ras gene mutations in human lung cancer: comparison of two screening assays based on the polymerase chain reaction.
Adenocarcinoma
Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma.
Adenocarcinoma
Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms.
Adenocarcinoma
Diagnostic value of digital droplet polymerase chain reaction and digital multiplexed detection of single-nucleotide variants in pancreatic cytology specimens collected by EUS-guided FNA.
Adenocarcinoma
Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis.
Adenocarcinoma
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Adenocarcinoma
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Adenocarcinoma
Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.
Adenocarcinoma
Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition.
Adenocarcinoma
Differentially expressed genes associated with mouse lung tumor progression.
Adenocarcinoma
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Adenocarcinoma
Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.
Adenocarcinoma
Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K-ras gene mutation in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Adenocarcinoma
Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
Adenocarcinoma
DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
Adenocarcinoma
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Adenocarcinoma
Ductal origin of pancreatic adenocarcinomas induced by conditional activation of a human Ha-ras oncogene in rat pancreas.
Adenocarcinoma
Early growth response-1 induces and enhances vascular endothelial growth factor-a expression in lung cancer cells.
Adenocarcinoma
East meets West: ethnic differences in epidemiology and clinical behaviors of lung cancer between East Asians and Caucasians.
Adenocarcinoma
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Adenocarcinoma
Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Adenocarcinoma
Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells.
Adenocarcinoma
Effects of vitamin D in lung, stomach, esophagus and testis tissues following administration of urethane in balb/c mice.
Adenocarcinoma
EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
Adenocarcinoma
EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
Adenocarcinoma
EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition.
Adenocarcinoma
EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
Adenocarcinoma
Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells.
Adenocarcinoma
EphA2 in the early pathogenesis and progression of non-small cell lung cancer.
Adenocarcinoma
Epigenetic inactivation of tumor suppressor SFRP2 and point mutation in KRAS proto-oncogene in fistula-associated mucinous type anal adenocarcinoma: report of two cases.
Adenocarcinoma
Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
Adenocarcinoma
Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.
Adenocarcinoma
Expression of Elongation Factor (EF)-Tu Is Correlated with Prognosis of Gastric Adenocarcinomas.
Adenocarcinoma
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Adenocarcinoma
Expression of oncogenic K-ras and loss of Smad4 cooperate to induce the expression of EGFR and to promote invasion of immortalized human pancreas ductal cells.
Adenocarcinoma
Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.
Adenocarcinoma
Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector.
Adenocarcinoma
Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Adenocarcinoma
Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal adenocarcinomas from Taiwan.
Adenocarcinoma
Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.
Adenocarcinoma
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
Adenocarcinoma
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Adenocarcinoma
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Adenocarcinoma
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Adenocarcinoma
Gene mutations and altered gene expression in azoxymethane-induced colon carcinogenesis in rodents.
Adenocarcinoma
Genetic alterations in mouse lung tumors: implications for cancer chemoprevention.
Adenocarcinoma
Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
Adenocarcinoma
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Adenocarcinoma
Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
Adenocarcinoma
Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.
Adenocarcinoma
Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.
Adenocarcinoma
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
Adenocarcinoma
Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration.
Adenocarcinoma
Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant p21 ras.
Adenocarcinoma
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
Adenocarcinoma
High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
Adenocarcinoma
High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival.
Adenocarcinoma
High expression of RAB38 promotes malignant progression of pancreatic cancer.
Adenocarcinoma
High incidence of point mutation in K-ras codon 12 in carcinoma of the fallopian tube.
Adenocarcinoma
High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.
Adenocarcinoma
Identification of biomarkers and their functions in dasatinib-resistant pancreatic cancer using bioinformatics analysis.
Adenocarcinoma
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Adenocarcinoma
Immunophenotype and K-RAS mutation in mucinous ovarian adenocarcinoma with mural nodule of high-grade sarcoma: case report.
Adenocarcinoma
Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
Adenocarcinoma
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
Adenocarcinoma
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Adenocarcinoma
Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia.
Adenocarcinoma
Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Adenocarcinoma
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Adenocarcinoma
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Adenocarcinoma
Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue.
Adenocarcinoma
Integrated analysis and knockdown of RAB23 indicate the role of RAB23 in gastric adenocarcinoma.
Adenocarcinoma
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Adenocarcinoma
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma.
Adenocarcinoma
Intraductal papillary mucinous tumors: a case report and review of literature.
Adenocarcinoma
Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation.
Adenocarcinoma
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.
Adenocarcinoma
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
Adenocarcinoma
K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
Adenocarcinoma
K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
Adenocarcinoma
K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions.
Adenocarcinoma
K-ras and p53 alterations in genomic DNA and transcripts of human pancreatic adenocarcinoma cell lines.
Adenocarcinoma
K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.
Adenocarcinoma
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Adenocarcinoma
K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
Adenocarcinoma
K-ras codon 12 mutations in Barrett's oesophagus and adenocarcinomas of the oesophagus and oesophagogastric junction.
Adenocarcinoma
K-ras codon 12 mutations of the super-minute dysplasia in Barrett's esophagus by DNA extraction using a microdissection method.
Adenocarcinoma
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
Adenocarcinoma
K-ras gene mutation in sputum samples containing atypical cells and adenocarcinoma cells in the lung.
Adenocarcinoma
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
Adenocarcinoma
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
Adenocarcinoma
K-ras gene point mutations and p21ras immunostaining in human ovarian tumors.
Adenocarcinoma
K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
Adenocarcinoma
K-ras mutation analysis of residual liquid-based cytology specimens from endoscopic ultrasound-guided fine needle aspiration improves cell block diagnosis of pancreatic ductal adenocarcinoma.
Adenocarcinoma
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
Adenocarcinoma
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
Adenocarcinoma
K-ras mutation at codon 12 in stage I pancreatic adenocarcinoma: analysis by laser capture microdissection and direct sequencing.
Adenocarcinoma
K-ras mutation in Greek patients with poorly and moderately differenciated tumours of the lower intestinal tract.
Adenocarcinoma
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
Adenocarcinoma
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Adenocarcinoma
K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas.
Adenocarcinoma
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
Adenocarcinoma
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
Adenocarcinoma
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
Adenocarcinoma
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
Adenocarcinoma
K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.
Adenocarcinoma
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
Adenocarcinoma
K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
Adenocarcinoma
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
Adenocarcinoma
K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust.
Adenocarcinoma
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
Adenocarcinoma
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Adenocarcinoma
K-RAS mutations indicating primary resistance to crizotinib in ALK-rearranged adenocarcinomas of the lung: Report of two cases and review of the literature.
Adenocarcinoma
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.
Adenocarcinoma
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
Adenocarcinoma
K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.
Adenocarcinoma
K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung.
Adenocarcinoma
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Adenocarcinoma
K-ras oncogene subtype mutations are associated with survival but not expression of p53, p16(INK4A), p21(WAF-1), cyclin D1, erbB-2 and erbB-3 in resected pancreatic ductal adenocarcinoma.
Adenocarcinoma
K-ras point mutation detection in lung cancer: comparison of two approaches to somatic mutation detection using ARMS allele-specific amplification.
Adenocarcinoma
K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors.
Adenocarcinoma
K-ras point mutations are rare events in premalignant forms of Barrett's oesophagus.
Adenocarcinoma
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
Adenocarcinoma
K-Ras promotes growth transformation and invasion of immortalized human pancreatic cells by Raf and phosphatidylinositol 3-kinase signaling.
Adenocarcinoma
Lack of apoptosis in PanIN-1 and PanIN-2 lesions associated with pancreatic ductal adenocarcinoma is not dependent on K-ras status.
Adenocarcinoma
Lack of correlation between codon 12 K-ras mutations and major histocompatibility complex antigens in bronchogenic carcinomas.
Adenocarcinoma
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Adenocarcinoma
Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras.
Adenocarcinoma
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Adenocarcinoma
Low Prevalence of K-RAS, EGF-R and BRAF Mutations in Sinonasal Adenocarcinomas. Implications for Anti-EGFR Treatments.
Adenocarcinoma
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
Adenocarcinoma
Metabolomic and transcriptomic profiling of human K-ras oncogene transgenic rats with pancreatic ductal adenocarcinomas.
Adenocarcinoma
Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.
Adenocarcinoma
MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
Adenocarcinoma
Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis.
Adenocarcinoma
Microsatellite instability in sporadic and inherited colon adenocarcinomas from Greek patients: correlation with several clinicopathological characteristics.
Adenocarcinoma
Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.
Adenocarcinoma
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Adenocarcinoma
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Adenocarcinoma
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Adenocarcinoma
Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
Adenocarcinoma
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
Adenocarcinoma
Molecular detection of tumor cells in bronchoalveolar lavage fluid from patients with early stage lung cancer.
Adenocarcinoma
Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique.
Adenocarcinoma
Molecular diagnostic testing as an adjunct to morphologic evaluation of pancreatic ductal system brushings: potential augmentation for diagnostic sensitivity.
Adenocarcinoma
Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.
Adenocarcinoma
Molecular genetic tumor markers in the early diagnosis and screening of non-small-cell lung cancer.
Adenocarcinoma
MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
Adenocarcinoma
Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations.
Adenocarcinoma
Mucinous bronchioloalveolar carcinoma with K-ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature.
Adenocarcinoma
Mucinous cystic neoplasms of the pancreas: pathology and molecular genetics.
Adenocarcinoma
Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
Adenocarcinoma
Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers.
Adenocarcinoma
Murine lung tumor measurement using respiratory-gated micro-computed tomography.
Adenocarcinoma
Mutation in the K-ras gene at codon 12 does not correlate with disease progression in colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy.
Adenocarcinoma
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study.
Adenocarcinoma
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Adenocarcinoma
Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.
Adenocarcinoma
Mutations in K-Ras linked to levels of osteoprotegerin and sensitivity to TRAIL-induced cell death in pancreatic ductal adenocarcinoma cells.
Adenocarcinoma
Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas.
Adenocarcinoma
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
Adenocarcinoma
Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.
Adenocarcinoma
Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.
Adenocarcinoma
Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy.
Adenocarcinoma
Naturally Occurring T-Cell Response against Mutated p21 Ras Oncoprotein in Pancreatic Cancer.
Adenocarcinoma
Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan.
Adenocarcinoma
Neurotensin is a versatile modulator of in vitro human Pancreatic Ductal Adenocarcinoma Cell (PDAC) migration.
Adenocarcinoma
Neurotensin stimulates protein kinase C-dependent mitogenic signaling in human pancreatic carcinoma cell line PANC-1.
Adenocarcinoma
Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis.
Adenocarcinoma
Nobiletin, a citrus flavonoid, suppresses invasion and migration involving FAK/PI3K/Akt and small GTPase signals in human gastric adenocarcinoma AGS cells.
Adenocarcinoma
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.
Adenocarcinoma
Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
Adenocarcinoma
Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma.
Adenocarcinoma
Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-?B Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.
Adenocarcinoma
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Adenocarcinoma
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells.
Adenocarcinoma
Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
Adenocarcinoma
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
Adenocarcinoma
p16(INK4a) and histology-specific methylation of CpG islands by exposure to tobacco smoke in non-small cell lung cancer.
Adenocarcinoma
p53 and ras gene expression in human esophageal cancer and Barrett's epithelium: a prospective study.
Adenocarcinoma
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Adenocarcinoma
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
Adenocarcinoma
Pancreatic Cancer Signaling Pathways, Genetic Alterations, and Tumor Microenvironment: The Barriers Affecting the Method of Treatment.
Adenocarcinoma
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Adenocarcinoma
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Adenocarcinoma
Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study.
Adenocarcinoma
Patterns of K-ras codon 12 and 13 mutations found in pancreatic adenocarcinoma of 30 Chinese patients by microdissection, PCR and direct sequencing.
Adenocarcinoma
Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
Adenocarcinoma
Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy.
Adenocarcinoma
Predictive advantage of a cell type classification for pulmonary adenocarcinoma coupled with data for p53, K-ras and EGFR alterations.
Adenocarcinoma
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Adenocarcinoma
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Adenocarcinoma
Primary signet-ring cell carcinoma of the lung: histochemical and immunohistochemical characterization.
Adenocarcinoma
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Adenocarcinoma
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Adenocarcinoma
Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
Adenocarcinoma
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis.
Adenocarcinoma
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Adenocarcinoma
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis.
Adenocarcinoma
Prognostic value of K-ras mutations, ras oncoprotein, and c-erb B-2 oncoprotein expression in adenocarcinoma of the lung.
Adenocarcinoma
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.
Adenocarcinoma
Proteinase-Activated Receptors Differentially Modulate In Vitro Invasion of Human Pancreatic Adenocarcinoma PANC-1 Cells in Correlation With Changes in the Expression of CDC42 Protein.
Adenocarcinoma
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice.
Adenocarcinoma
Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients.
Adenocarcinoma
R-(+)-perillyl alcohol-induced cell cycle changes, altered actin cytoskeleton, and decreased ras and p34(cdc2) expression in colonic adenocarcinoma SW480 cells.
Adenocarcinoma
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
Adenocarcinoma
Rac1b negatively regulates TGF-?1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.
Adenocarcinoma
Ran, a small GTPase gene, encodes cytotoxic T lymphocyte (CTL) epitopes capable of inducing HLA-A33-restricted and tumor-reactive CTLs in cancer patients.
Adenocarcinoma
Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea.
Adenocarcinoma
Ras gene activation in malignant cells of human ovarian carcinoma peritoneal fluids.
Adenocarcinoma
ras gene mutations as a prognostic marker in adenocarcinoma of the human lung without lymph node metastasis.
Adenocarcinoma
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications.
Adenocarcinoma
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Adenocarcinoma
Ras-driven transformation of human nestin-positive pancreatic epithelial cells.
Adenocarcinoma
Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas.
Adenocarcinoma
Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers.
Adenocarcinoma
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.
Adenocarcinoma
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Adenocarcinoma
Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.
Adenocarcinoma
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Adenocarcinoma
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.
Adenocarcinoma
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Adenocarcinoma
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
Adenocarcinoma
Results of a Phase I Trial of 12 Patients With Locally Advanced Pancreatic Carcinoma Combining Gefitinib, Paclitaxel, and 3-Dimensional Conformal Radiation: Report of Toxicity and Evaluation of Circulating K-ras as a Potential Biomarker of Response to Therapy.
Adenocarcinoma
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Adenocarcinoma
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Adenocarcinoma
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
Adenocarcinoma
Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma.
Adenocarcinoma
Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the A/J mouse.
Adenocarcinoma
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Adenocarcinoma
Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites.
Adenocarcinoma
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Adenocarcinoma
Sex differences in clinicopathological features of peripheral T1 adenocarcinoma of the lung.
Adenocarcinoma
Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer.
Adenocarcinoma
SKA1 regulates actin cytoskeleton remodelling via activating Cdc42 and influences the migration of pancreatic ductal adenocarcinoma cells.
Adenocarcinoma
Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases.
Adenocarcinoma
Smoking, oncogenes and human lung cancer. A review of recent laboratory evidence linking smoking and lung cancer.
Adenocarcinoma
Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.
Adenocarcinoma
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.
Adenocarcinoma
Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.
Adenocarcinoma
STIM1 phosphorylation triggered by epidermal growth factor mediates cell migration.
Adenocarcinoma
Studies on clinicopathological features of lung cancer patients with K-ras/p53 gene alterations: comparison between younger and older groups.
Adenocarcinoma
Study on association between H-ras gene polymorphism and gastric adenocarcinoma risk.
Adenocarcinoma
Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer.
Adenocarcinoma
Survey of ferns and clinico-pathological studies on the field cases of Enzootic bovine haematuria in Himachal Pradesh, a north-western Himalayan state of India.
Adenocarcinoma
Survival after surgical management of pancreatic adenocarcinoma: does curative and radical surgery truly exist?
Adenocarcinoma
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
Adenocarcinoma
T1, an immunoglobulin superfamily member, is expressed in H-ras-dependent epithelial tumours of mammary cells.
Adenocarcinoma
Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System.
Adenocarcinoma
Targeting Mutated K-ras in Pancreatic Adenocarcinoma Using an Adjuvant Vaccine.
Adenocarcinoma
Targeting phosphoinositide 3-kinase pathways in pancreatic cancer--from molecular signalling to clinical trials.
Adenocarcinoma
Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation.
Adenocarcinoma
The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.
Adenocarcinoma
The clinical significance of K-ras mutation in endometrial "surface epithelial changes" and their associated endometrial adenocarcinoma.
Adenocarcinoma
The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma.
Adenocarcinoma
The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting.
Adenocarcinoma
The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium.
Adenocarcinoma
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.
Adenocarcinoma
The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance.
Adenocarcinoma
The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.
Adenocarcinoma
The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lung.
Adenocarcinoma
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
Adenocarcinoma
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.
Adenocarcinoma
The prognostic significance of tumor-associated markers p53, HER-2/neu, c-myc, v-H-ras, PCNA and EGFr of local and distant recurrence in localized human prostatic adenocarcinoma.
Adenocarcinoma
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Adenocarcinoma
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
Adenocarcinoma
The role of K-ras gene mutation analysis in EUS-guided FNA cytology specimens for the differential diagnosis of pancreatic solid masses: a meta-analysis of prospective studies.
Adenocarcinoma
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
Adenocarcinoma
The utility of cytology in the diagnosis of adenocarcinoma lung: A tertiary care center study.
Adenocarcinoma
Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer.
Adenocarcinoma
TP53, p14ARF, p16INK4a and H-ras gene molecular analysis in intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.
Adenocarcinoma
Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: impact of K-ras mutations.
Adenocarcinoma
Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.
Adenocarcinoma
Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients.
Adenocarcinoma
Update on phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness?
Adenocarcinoma
Usufuleness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Adenocarcinoma
Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation.
Adenocarcinoma
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Adenocarcinoma
Vav1 and mutant K-Ras synergize in the early development of pancreatic ductal adenocarcinoma in mice.
Adenocarcinoma
VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations.
Adenocarcinoma
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
Adenocarcinoma
[Activation of K-ras and c-erbB-2 protooncogenes in human colonic adenocarcinomas]
Adenocarcinoma
[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]
Adenocarcinoma
[Demonstration of molecular forms of Rap 1 in cells or tissues deriving from normal or pathological human colonic epithelium]
Adenocarcinoma
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
Adenocarcinoma
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Adenocarcinoma
[Detection of micrometastases after curative resection for ductal adenocarcinoma of the pancreas]
Adenocarcinoma
[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
Adenocarcinoma
[General rules for the study of pancreatic cancer by molecular biological aspect]
Adenocarcinoma
[Mechanisms of action of targeted therapies... and mechanisms of resistance]
Adenocarcinoma
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
Adenocarcinoma
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer]
Adenocarcinoma
[Reversal of pulmonary hypertrophic osteoarthropathy in surgically treated lung cancer].
Adenocarcinoma
[Study on the mutations of p53 and K-ras gene in the cancer tissues and sputum cells of patients with lung cancer.]
Adenocarcinoma
[The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.]
Adenocarcinoma of Lung
5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model.
Adenocarcinoma of Lung
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
Adenocarcinoma of Lung
A genetic mouse model for metastatic lung cancer with gender differences in survival.
Adenocarcinoma of Lung
A selective small molecule inhibitor of c-Met, PHA-665752, reverses lung premalignancy induced by mutant K-ras.
Adenocarcinoma of Lung
A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis.
Adenocarcinoma of Lung
Activation of K-ras in aflatoxin B1-induced lung tumors from AC3F1 (A/J x C3H/HeJ) mice.
Adenocarcinoma of Lung
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Adenocarcinoma of Lung
Alterations of K-ras, p53, and erbB-2/neu in human lung adenocarcinomas.
Adenocarcinoma of Lung
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Adenocarcinoma of Lung
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.
Adenocarcinoma of Lung
Analysis of the role of DAMTC in lung adenocarcinoma cells based on the DNA microarrays.
Adenocarcinoma of Lung
Chromosomal alterations in lung adenocarcinoma from smokers and nonsmokers.
Adenocarcinoma of Lung
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Adenocarcinoma of Lung
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
Adenocarcinoma of Lung
CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas.
Adenocarcinoma of Lung
Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation.
Adenocarcinoma of Lung
Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.
Adenocarcinoma of Lung
Clonality status of multifocal lung adenocarcinomas based on the mutation patterns of EGFR and K-ras.
Adenocarcinoma of Lung
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
Adenocarcinoma of Lung
Combining an FPTase inhibitor with cisplatin facilitates induction of apoptosis in human A549 lung cancer cells.
Adenocarcinoma of Lung
Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status.
Adenocarcinoma of Lung
Computed tomographic images reflect the biologic behavior of small lung adenocarcinoma: they correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix, and K-ras mutation.
Adenocarcinoma of Lung
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.
Adenocarcinoma of Lung
Cytochrome c oxidase is activated by the oncoprotein Ras and is required for A549 lung adenocarcinoma growth.
Adenocarcinoma of Lung
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Adenocarcinoma of Lung
Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.
Adenocarcinoma of Lung
Detection of codon 12 K-ras mutations in non-neoplastic mucosa from bronchial carina in patients with lung adenocarcinomas.
Adenocarcinoma of Lung
Detection of codon 12 point mutations of the K-ras gene from mouse lung adenocarcinoma by 'enriched' PCR.
Adenocarcinoma of Lung
Detection of EGFR and K-ras mutations for diagnosis of multiple lung adenocarcinomas.
Adenocarcinoma of Lung
Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.
Adenocarcinoma of Lung
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Adenocarcinoma of Lung
Detection of k-ras point mutations in codons 12 and 13 in non-small cell lung cancers.
Adenocarcinoma of Lung
Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
Adenocarcinoma of Lung
Differential response to 1?,25-dihydroxyvitamin D(3) (1?,25(OH)(2)D(3)) in non-small cell lung cancer cells with distinct oncogene mutations.
Adenocarcinoma of Lung
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Adenocarcinoma of Lung
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Adenocarcinoma of Lung
DNA damage, superoxide, and mutant K-ras in human lung adenocarcinoma cells.
Adenocarcinoma of Lung
Effects of perillyl alcohol and heat shock treatment in gene expression of human lung adenocarcinoma cell line A549.
Adenocarcinoma of Lung
EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition.
Adenocarcinoma of Lung
EGFR mutations in non-small-cell lung cancer: analysis of a large series of cases and development of a rapid and sensitive method for diagnostic screening with potential implications on pharmacologic treatment.
Adenocarcinoma of Lung
EphA2 in the early pathogenesis and progression of non-small cell lung cancer.
Adenocarcinoma of Lung
Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies.
Adenocarcinoma of Lung
Epidermal growth factor receptor and K-RAS mutations in 411 lung adenocarcinoma: a population-based prospective study.
Adenocarcinoma of Lung
Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung.
Adenocarcinoma of Lung
Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity.
Adenocarcinoma of Lung
Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer.
Adenocarcinoma of Lung
Favorable response to erlotinib in a lung adenocarcinoma with both epidermal growth factor receptor exon 19 deletion and K-ras G13D mutations.
Adenocarcinoma of Lung
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Adenocarcinoma of Lung
Fibulin-2 is a driver of malignant progression in lung adenocarcinoma.
Adenocarcinoma of Lung
Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2-M and induces ROS-independent apoptosis in A549 cells, targeting nuclear DNA.
Adenocarcinoma of Lung
Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.)
Adenocarcinoma of Lung
Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus.
Adenocarcinoma of Lung
Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.
Adenocarcinoma of Lung
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
Adenocarcinoma of Lung
High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.
Adenocarcinoma of Lung
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Adenocarcinoma of Lung
Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma.
Adenocarcinoma of Lung
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
Adenocarcinoma of Lung
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Adenocarcinoma of Lung
Increased K-ras protein and activity in mouse and human lung epithelial cells at confluence.
Adenocarcinoma of Lung
Increased prevalence of K-ras oncogene mutations in lung adenocarcinoma.
Adenocarcinoma of Lung
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
Adenocarcinoma of Lung
Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin.
Adenocarcinoma of Lung
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
Adenocarcinoma of Lung
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Adenocarcinoma of Lung
Integrating RAS Status into Prognostic Signatures for Adenocarcinomas of the Lung.
Adenocarcinoma of Lung
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Adenocarcinoma of Lung
Interplay between estrogen and Stat3/NF-?B-driven immunomodulation in lung cancer.
Adenocarcinoma of Lung
Interplay between menin and K-Ras in regulating lung adenocarcinoma.
Adenocarcinoma of Lung
JAK-STAT inhibition impairs K-RAS-driven lung adenocarcinoma progression.
Adenocarcinoma of Lung
K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.
Adenocarcinoma of Lung
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
Adenocarcinoma of Lung
K-ras gene mutation in sputum samples containing atypical cells and adenocarcinoma cells in the lung.
Adenocarcinoma of Lung
K-ras gene mutations: an unfavorable prognostic marker in stage I lung adenocarcinoma.
Adenocarcinoma of Lung
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
Adenocarcinoma of Lung
K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
Adenocarcinoma of Lung
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
Adenocarcinoma of Lung
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
Adenocarcinoma of Lung
K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung.
Adenocarcinoma of Lung
K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.
Adenocarcinoma of Lung
K-ras oncogene activation in lung adenocarcinomas from former smokers. Evidence that K-ras mutations are an early and irreversible event in the development of adenocarcinoma of the lung.
Adenocarcinoma of Lung
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
Adenocarcinoma of Lung
K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.
Adenocarcinoma of Lung
KIF5B-RET Fusion gene may coincide oncogenic mutations of EGFR or KRAS gene in lung adenocarcinomas.
Adenocarcinoma of Lung
KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach.
Adenocarcinoma of Lung
Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254.
Adenocarcinoma of Lung
Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile.
Adenocarcinoma of Lung
MicroRNA-149 inhibits the progression of lung adenocarcinoma through targeting RAP1B and inactivating Wnt/?-catenin pathway.
Adenocarcinoma of Lung
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Adenocarcinoma of Lung
miRNA-34 prevents cancer initiation and progression in a therapeutically-resistant K-ras and p53-induced mouse model of lung adenocarcinoma.
Adenocarcinoma of Lung
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Adenocarcinoma of Lung
Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma.
Adenocarcinoma of Lung
Mutant K-rasV12 increases COX-2, peroxides and DNA damage in lung cells.
Adenocarcinoma of Lung
Mutational analysis of AKT1, AKT2 and AKT3 genes in common human carcinomas.
Adenocarcinoma of Lung
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
Adenocarcinoma of Lung
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Adenocarcinoma of Lung
Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.
Adenocarcinoma of Lung
Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
Adenocarcinoma of Lung
Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.
Adenocarcinoma of Lung
Nullifying the CDKN2A/B Locus Promotes Mutant K-ras Lung Tumorigenesis.
Adenocarcinoma of Lung
Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma.
Adenocarcinoma of Lung
Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.
Adenocarcinoma of Lung
p38? negatively regulates survival and malignant selection of transformed bronchioalveolar stem cells.
Adenocarcinoma of Lung
Phosphatidylinositol 3-kinase mediates bronchioalveolar stem cell expansion in mouse models of oncogenic K-ras-induced lung cancer.
Adenocarcinoma of Lung
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Adenocarcinoma of Lung
Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64.
Adenocarcinoma of Lung
Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Adenocarcinoma of Lung
Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.
Adenocarcinoma of Lung
Ras oncogene point mutation: an infrequent event in bronchioloalveolar cancer.
Adenocarcinoma of Lung
RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Adenocarcinoma of Lung
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.
Adenocarcinoma of Lung
Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.
Adenocarcinoma of Lung
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Adenocarcinoma of Lung
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Adenocarcinoma of Lung
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
Adenocarcinoma of Lung
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
Adenocarcinoma of Lung
Silenced Expression of NFKBIA in Lung Adenocarcinoma Patients with a Never-smoking History.
Adenocarcinoma of Lung
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Adenocarcinoma of Lung
Synergistic cell growth inhibition by the combination of amrubicin and Akt-suppressing agents in K-ras mutation-harboring lung adenocarcinoma cells: implication of EGFR tyrosine kinase inhibitors.
Adenocarcinoma of Lung
Synthesis and evaluation of bis-thiazole derivatives as new anticancer agents.
Adenocarcinoma of Lung
The differential effects of mutant p53 alleles on advanced murine lung cancer.
Adenocarcinoma of Lung
The Human Immunodeficiency Virus Protease Inhibitor Ritonavir Inhibits Lung Cancer Cells, in Part, by Inhibition of Survivin.
Adenocarcinoma of Lung
The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.
Adenocarcinoma of Lung
The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42.
Adenocarcinoma of Lung
The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance.
Adenocarcinoma of Lung
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
Adenocarcinoma of Lung
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
Adenocarcinoma of Lung
[CRAF, a key player in lung adenocarcinomas induced by K-Ras oncogene].
Adenocarcinoma of Lung
[Detection of ALK positive pulmonary adenocarcinoma using immunostaining].
Adenocarcinoma of Lung
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Adenocarcinoma of Lung
[Impact of prenylation inhibition on RAS mutant tumors in preclinical studies].
Adenocarcinoma of Lung
[KRAS and bronchial adenocarcinoma. Between disappointments and hopes].
Adenocarcinoma of Lung
[Synchronous Multiple Primary Lung Cancer Dignosed ?by Different Phenotype-genotype: A Case Report and Literature Review].
Adenocarcinoma, Bronchiolo-Alveolar
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Adenocarcinoma, Bronchiolo-Alveolar
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Adenocarcinoma, Bronchiolo-Alveolar
Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.
Adenocarcinoma, Bronchiolo-Alveolar
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Adenocarcinoma, Bronchiolo-Alveolar
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Adenocarcinoma, Bronchiolo-Alveolar
Mucinous bronchioloalveolar carcinoma with K-ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature.
Adenocarcinoma, Clear Cell
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
Adenocarcinoma, Follicular
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
Adenocarcinoma, Follicular
Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gln-->Leu61).
Adenocarcinoma, Mucinous
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Adenocarcinoma, Mucinous
Analysis of clonality by amplification of short tandem repeats. Carcinomas of the female reproductive tract.
Adenocarcinoma, Mucinous
Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations.
Adenocarcinoma, Mucinous
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Adenocarcinoma, Mucinous
Direct Correlation Between Double K-RAS Mutation and Mucinous Carcinoma. A Case Report.
Adenocarcinoma, Mucinous
Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
Adenocarcinoma, Mucinous
Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
Adenocarcinoma, Mucinous
Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation.
Adenocarcinoma, Mucinous
K-ras activation in neoplasms of the human female reproductive tract.
Adenocarcinoma, Mucinous
K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary.
Adenocarcinoma, Mucinous
Mucinous adenocarcinoma arising from supratentorial intramedullary neuroenteric cyst with broncho-pulmonary differentiation.
Adenocarcinoma, Mucinous
Mucinous adenocarcinoma with lepidic pattern and with K-RAS mutation in a newborn with antenatal diagnosis of congenital pulmonary airway malformation.
Adenocarcinoma, Mucinous
Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics.
Adenocarcinoma, Mucinous
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?
Adenocarcinoma, Mucinous
P53 mutation but not p16/MTS1 mutation occurs in intraductal papillary mucinous tumors of the pancreas.
Adenocarcinoma, Papillary
A repeated pancreatectomy in the remnant pancreas 22 months after pylorus-preserving pancreatoduodenectomy for pancreatic adenocarcinoma.
Adenocarcinoma, Papillary
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
Adenocarcinoma, Papillary
[Detection of point mutation of Kirsten ras oncogene in pancreatic carcinoma by polymerase chain reaction]
Adenoma
A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice.
Adenoma
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
Adenoma
A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma.
Adenoma
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
Adenoma
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
Adenoma
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Adenoma
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
Adenoma
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Adenoma
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Adenoma
Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.
Adenoma
Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis.
Adenoma
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Adenoma
Adenoma-carcinoma sequence of colorectum. Prevalence of K-ras gene mutation in adenomas with increasing degree of dysplasia and aneuploidy.
Adenoma
Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis.
Adenoma
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
Adenoma
Analysis of K-ras codon 12 mutation in flat and nodular variants of serrated adenoma in the colon.
Adenoma
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Adenoma
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
Adenoma
Analysis of the genetic alterations in a case of juvenile multiple colon carcinoma with hypogammaglobulinemia.
Adenoma
Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
Adenoma
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
Adenoma
c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
Adenoma
CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.
Adenoma
Cell surface overexpression of galectin-3 and the presence of its ligand 90k in the blood plasma as determinants in colon neoplastic lesions.
Adenoma
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Adenoma
Classification of advanced colorectal carcinomas by tumor edge morphology: evidence for different pathogenesis and significance of polypoid and nonpolypoid tumors.
Adenoma
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
Adenoma
Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel.
Adenoma
Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individual.
Adenoma
Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas.
Adenoma
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Adenoma
Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancers.
Adenoma
Detailed analysis of genetic alterations in colorectal tumors from patients with and without familial adenomatous polyposis (FAP).
Adenoma
Detection of colorectal cancer K-ras mutations using a simplified oligonucleotide ligation assay.
Adenoma
Detection of genetic alterations in the p53 suppressor gene and the K-ras oncogene among different grades of dysplasia in patients with colorectal adenomas.
Adenoma
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Adenoma
Detection of k-ras mutation in normal and malignant colonic tissues by an enriched PCR method.
Adenoma
Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
Adenoma
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Adenoma
Detection of up to 65% of Precancerous Lesions of the Human Colon and Rectum by Mutation Analysis of APC, K-Ras, B-Raf and CTNNB1.
Adenoma
Diet, lifestyle and risk of K-ras mutation-positive and -negative colorectal adenomas.
Adenoma
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Adenoma
Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
Adenoma
Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.
Adenoma
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Adenoma
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Adenoma
Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: relationship to distribution of proliferating cells.
Adenoma
Effects of K-ras gene mutations in the development of lung lesions induced by 4-(N-methyl-n-nitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Adenoma
Effects of vitamin D in lung, stomach, esophagus and testis tissues following administration of urethane in balb/c mice.
Adenoma
Expression of human Krev-1 gene in lungs of transgenic mice and subsequent reduction in multiplicity of ethyl carbamate-induced lung adenomas.
Adenoma
Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon.
Adenoma
Expression of the glucocorticoid receptor and K-ras genes in urethan-induced mouse lung tumors and transformed cell lines.
Adenoma
Flat-elevated and depressed, subtypes of flat early colorectal cancers, should be distinguished by their pathological features.
Adenoma
Frequent altered expression of fragile histidine triad protein in human colorectal adenomas.
Adenoma
From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy.
Adenoma
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Adenoma
Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Adenoma
Genetic alterations in ovarian carcinoma: with specific reference to histological subtypes.
Adenoma
Genetic alterations in serrated adenomas: comparison to conventional adenomas and hyperplastic polyps.
Adenoma
Genetic alterations in the 61st codon of the H-ras oncogene isolated from archival sections of hepatic hyperplasias, adenomas and carcinomas in control groups of B6C3F1 mouse bioassay studies conducted from 1979 to 1986.
Adenoma
Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum.
Adenoma
Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas.
Adenoma
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Adenoma
Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas.
Adenoma
Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression.
Adenoma
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Adenoma
Germline and somatic mutations in exon 15 of the APC gene and K-ras mutations in duodenal adenomas in patients with familial adenomatous polyposis.
Adenoma
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Adenoma
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
Adenoma
Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation.
Adenoma
High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice.
Adenoma
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
Adenoma
High prevalence of sessile serrated adenomas with BRAF mutations: a prospective study of patients undergoing colonoscopy.
Adenoma
Histological and genetic changes in malignant transformation of gallbladder adenoma.
Adenoma
Human colorectal mucosal O6-alkylguanine DNA-alkyltransferase activity and DNA-N7-methylguanine levels in colorectal adenoma cases and matched referents.
Adenoma
Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer.
Adenoma
Hyperplastic polyps and sessile serrated adenomas as a phenotypic expression of MYH-associated polyposis.
Adenoma
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Adenoma
Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.
Adenoma
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Adenoma
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Adenoma
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Adenoma
Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer.
Adenoma
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.
Adenoma
Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
Adenoma
K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
Adenoma
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
Adenoma
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
Adenoma
K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
Adenoma
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
Adenoma
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
Adenoma
K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient.
Adenoma
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
Adenoma
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
Adenoma
K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
Adenoma
K-ras point mutations in routinely processed tissues: non-radioactive screening by single strand conformational polymorphism analysis.
Adenoma
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Adenoma
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
Adenoma
Laterally spreading type of colorectal adenoma exhibits a unique methylation phenotype and K-ras mutations.
Adenoma
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Adenoma
Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.
Adenoma
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Adenoma
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
Adenoma
Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas.
Adenoma
Meat consumption and preparation, and genetic susceptibility in relation to colorectal adenomas.
Adenoma
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Adenoma
Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
Adenoma
Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
Adenoma
Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis.
Adenoma
Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.
Adenoma
Molecular genetic analysis of appendiceal mucinous adenomas in identical twins, including one with pseudomyxoma peritonei.
Adenoma
Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women.
Adenoma
Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.
Adenoma
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Adenoma
Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Adenoma
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Adenoma
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Adenoma
Mutation of K-ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors.
Adenoma
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Adenoma
Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations.
Adenoma
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
Adenoma
PCR-SSCP analysis of human adrenocortical adenomas: absence of K-ras gene mutations.
Adenoma
Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice.
Adenoma
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
Adenoma
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
Adenoma
Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
Adenoma
Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.
Adenoma
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
Adenoma
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts.
Adenoma
ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Adenoma
Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents.
Adenoma
Relationship between cyclooxygenase-2 expression and K-ras gene mutation in colorectal adenomas.
Adenoma
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Adenoma
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Adenoma
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
Adenoma
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Adenoma
Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma.
Adenoma
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
Adenoma
Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan.
Adenoma
Serrated adenomas have a pattern of genetic alterations that distinguishes them from other colorectal polyps.
Adenoma
Single-Pattern Convergence of K-ras Mutation Correlates With Surgical Indication of Intraductal Papillary Mucinous Neoplasms.
Adenoma
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Adenoma
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Adenoma
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
Adenoma
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
Adenoma
The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility.
Adenoma
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
Adenoma
Thyroid hormone receptor beta1 in normal colon and colorectal cancer-association with differentiation, polypoid growth type and K-ras mutations.
Adenoma
Transfection and expression of mutant p53 protein does not alter the in vivo or in vitro growth characteristics of the AA/C1 human adenoma derived cell line, including sensitivity to transforming growth factor-beta 1.
Adenoma
Transforming growth factor beta1, ras and p53 in silica-induced fibrogenesis and carcinogenesis.
Adenoma
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Adenoma
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Adenoma
Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
Adenoma
["Field cancerization"--an additional phenomenon in development of colon tumors? K-ras codon 12 mutations in normal colonic mucosa of patients with colorectal neoplasms]
Adenoma
[A study on the mutation of P53 and K-ras gene in colorectal adenomas and colorectal carcinomas].
Adenoma
[Detection of K-ras point mutations in the stool of patients with colorectal tumors]
Adenoma
[Effect of PCBs on mouse lung tumorigenesis induced by 1-nitropyrene: a preliminary report]
Adenoma
[Genetic analysis of adenomatous polyposis coli: analysis of alterations of oncogenes and tumor suppressor genes in colorectal tumors]
Adenoma
[Influence of compensatory hepatocyte proliferation on the carcinogenesis of N-nitrosodimethylamine]
Adenoma
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Adenoma, Bile Duct
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Adenoma, Islet Cell
Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
Adenoma, Islet Cell
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Adenoma, Islet Cell
Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
Adenoma, Islet Cell
[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
Adenoma, Liver Cell
Correlation between Bcl-2 overexpression and H-ras mutation in naturally occurring hepatocellular proliferative lesions of the B6C3F1 mouse.
Adenoma, Liver Cell
H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883.
Adenoma, Liver Cell
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Adenoma, Liver Cell
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Adenoma, Liver Cell
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Adenoma, Villous
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
Adenoma, Villous
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Adenomatous Polyposis Coli
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
Adenomatous Polyposis Coli
Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept.
Adenomatous Polyposis Coli
Aberrant crypt foci: detection, gene abnormalities, and clinical usefulness.
Adenomatous Polyposis Coli
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Adenomatous Polyposis Coli
Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans.
Adenomatous Polyposis Coli
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Adenomatous Polyposis Coli
APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.
Adenomatous Polyposis Coli
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Adenomatous Polyposis Coli
Application of cycling gradient capillary electrophoresis to detection of APC, K-ras, and DCC point mutations in patients with sporadic colorectal tumors.
Adenomatous Polyposis Coli
Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.
Adenomatous Polyposis Coli
BRAF mutations in multiple sebaceous hyperplasias of patients belonging to MYH-associated polyposis pedigrees.
Adenomatous Polyposis Coli
Cancer risk assessment in long-standing pouchitis. DNA aberrations are rare in transformed neoplastic pelvic pouch mucosa.
Adenomatous Polyposis Coli
Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity.
Adenomatous Polyposis Coli
Clonality assessment and clonal ordering of individual neoplastic crypts shows polyclonality of colorectal adenomas.
Adenomatous Polyposis Coli
Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
Adenomatous Polyposis Coli
Colon carcinoma K-ras 2 oncogene of a familial polyposis coli patient.
Adenomatous Polyposis Coli
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
Adenomatous Polyposis Coli
Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individual.
Adenomatous Polyposis Coli
Differential colorectal carcinogenesis: Molecular basis and clinical relevance.
Adenomatous Polyposis Coli
DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.
Adenomatous Polyposis Coli
Fecal multiple molecular tests to detect colorectal cancer in stool.
Adenomatous Polyposis Coli
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Adenomatous Polyposis Coli
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Adenomatous Polyposis Coli
Genomic instability and colon carcinogenesis: from the perspective of genes.
Adenomatous Polyposis Coli
Germline and somatic mutations in exon 15 of the APC gene and K-ras mutations in duodenal adenomas in patients with familial adenomatous polyposis.
Adenomatous Polyposis Coli
High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
Adenomatous Polyposis Coli
Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancer-rarity of co-occurrence of mutations in APC, K-ras, and p53 genes.
Adenomatous Polyposis Coli
IQGAP1 Expression in Spared CA1 Neurons After an Excitotoxic Lesion in the Mouse Hippocampus.
Adenomatous Polyposis Coli
IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway.
Adenomatous Polyposis Coli
K-ras activation in colorectal tumors from patients with familial polyposis coli.
Adenomatous Polyposis Coli
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
Adenomatous Polyposis Coli
K-ras mutation and loss of heterozygosity at 17p with beta-catenin accumulation in intramucosal carcinoma of the ileostomy in familial adenomatous polyposis: a case report.
Adenomatous Polyposis Coli
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
Adenomatous Polyposis Coli
K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient.
Adenomatous Polyposis Coli
Molecular and biological analysis of carcinoma of the small intestine: beta-catenin gene mutation by interstitial deletion involving exon 3 and replication error phenotype.
Adenomatous Polyposis Coli
Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
Adenomatous Polyposis Coli
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Adenomatous Polyposis Coli
p53 and K-ras status in duodenal adenomas in familial adenomatous polyposis.
Adenomatous Polyposis Coli
Phenotype-genotype correlation: Challenge of intestinal-type adenocarcinoma of the nasal cavity and paranasal sinuses.
Adenomatous Polyposis Coli
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Adenomatous Polyposis Coli
Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.
Adenomatous Polyposis Coli
Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization.
Adenomatous Polyposis Coli
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Adenomatous Polyposis Coli
Sensitivity and specificity of a stool DNA multitarget assay panel for the detection of advanced colorectal neoplasia.
Adenomatous Polyposis Coli
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Adenomatous Polyposis Coli
Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.
Adenomatous Polyposis Coli
The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
Adenomatous Polyposis Coli
The origins of rimmed vacuoles and granulovacuolar degeneration bodies are associated with the Wnt signaling pathway.
Adenomatous Polyposis Coli
Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
Adenomatous Polyposis Coli
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Adenomatous Polyposis Coli
[K-ras gene mutations in adenomas from familial adenomatous polyposis]
Adenomatous Polyposis Coli
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Adenomatous Polyps
Detection of a K-ras mutation in urine of patients with colorectal cancer.
Adenomatous Polyps
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.
Adenomatous Polyps
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer.
Adenomyosis
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Adrenocortical Adenoma
PCR-SSCP analysis of human adrenocortical adenomas: absence of K-ras gene mutations.
Adrenocortical Carcinoma
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
Albinism
A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism.
Albinism
Griscelli Syndrome Type 2 Sine Albinism: Unraveling Differential RAB27A Effector Engagement.
Albinism
Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.
Albinism, Oculocutaneous
A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice.
Albinism, Oculocutaneous
Expression and characterization of Rab38, a new member of the Rab small G protein family.
Albinism, Oculocutaneous
Lethal hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type II.
Albinism, Oculocutaneous
Patients with Griscelli syndrome and normal pigmentation identify RAB27A mutations that selectively disrupt MUNC13-4 binding.
Albuminuria
The Rab-Rabphilin system in injured human podocytes stressed by glucose overload and angiotensin II.
Alzheimer Disease
A meta-analysis of transcriptomic profiles of Huntington's disease patients.
Alzheimer Disease
Altered Distribution of RhoA in Alzheimer's Disease and AbetaPP Overexpressing Mice.
Alzheimer Disease
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Alzheimer Disease
Altered Expression of Circulating Cdc42 in Frontotemporal Lobar Degeneration.
Alzheimer Disease
Association between thiopurine medication exposure and Alzheimer's disease among a cohort of patients with inflammatory bowel disease.
Alzheimer Disease
Behavioral effects of Rho GTPase modulation in a model of Alzheimer's disease.
Alzheimer Disease
Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of ?-secretase BACE1.
Alzheimer Disease
Oligomer ?-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice.
Alzheimer Disease
Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals.
Alzheimer Disease
Quantitation of glycogen synthase kinase-3 sensitive proteins in neuronal membrane rafts.
Alzheimer Disease
Re-exploring the core genes and modules in the human frontal cortex during chronological aging: insights from network-based analysis of transcriptomic studies.
Alzheimer Disease
Reduced expression of amyloid precursor protein, presenilin-1 and rab3a in cortical brain regions in Alzheimer's disease.
Alzheimer Disease
Reducing Endogenous ?-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model.
Alzheimer Disease
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.
Alzheimer Disease
[RhoA/ROCK pathway involved in effects of Sanjiao acupuncture on learning and memory and synaptic plasticity in Alzheimer's disease mice].
Ameloblastoma
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
Amyotrophic Lateral Sclerosis
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.
Amyotrophic Lateral Sclerosis
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.
Amyotrophic Lateral Sclerosis
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2.
Anemia
The scat mouse model highlights RASA3, a GTPase activating protein, as a key regulator of vertebrate erythropoiesis and megakaryopoiesis.
Angiomyolipoma
Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas.
Anus, Imperforate
Loss of function IFT27 variants associated with an unclassified lethal fetal ciliopathy with renal agenesis.
Aortic Coarctation
Effect of experimental hypertension on phosphoinositide hydrolysis and proto-oncogene expression in cardiovascular tissues.
Appendiceal Neoplasms
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Arteriosclerosis
Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo.
Arteriosclerosis
In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs.
Arteriosclerosis
Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice.
Arteriosclerosis
Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms.
Arteriosclerosis
Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats.
Arteriosclerosis
Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice.
Arteriosclerosis
RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals.
Arthritis
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis.
Arthritis
Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions.
Arthritis
RhoB blockade selectively inhibits autoantibody production in autoimmune models of rheumatoid arthritis and lupus.
Arthritis
T cell activation Rho GTPase activating protein (TAGAP) is upregulated in clinical and experimental arthritis.
Arthritis, Experimental
Silencing the Expression of Ras Family GTPase Homologues Decreases Inflammation and Joint Destruction in Experimental Arthritis.
Arthritis, Juvenile
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis.
Arthritis, Psoriatic
Rho-GTPase pathways may differentiate treatment response to TNF-alpha and IL-17A inhibitors in psoriatic arthritis.
Arthritis, Rheumatoid
HMG-CoA reductase inhibitor simvastatin suppresses Toll-like receptor 2 ligand-induced activation of nuclear factor kappa B by preventing RhoA activation in monocytes from rheumatoid arthritis patients.
Arthritis, Rheumatoid
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Arthritis, Rheumatoid
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.
Arthritis, Rheumatoid
Smoothened Regulates Migration of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via Activation of Rho GTPase Signaling.
Arthritis, Rheumatoid
Sustained T cell Rap1 signaling is protective in the collagen-induced arthritis model of rheumatoid arthritis.
Arthritis, Rheumatoid
Tetrandrine inhibits migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes through down-regulating the expressions of Rac1, Cdc42, and RhoA GTPases and activation of the PI3K/Akt and JNK signaling pathways.
Arthritis, Rheumatoid
[Modulation of RhoA/Rho kinase on migration, invasion and proliferation of fibroblast like synoviocytes from patients with rheumatoid arthritis].
Arthritis, Rheumatoid
[Modulation of RhoA/ROCK pathway on TLR-2 ligand-induced chemokine secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis].
Asbestosis
Comparative analysis of p16/CDKN2, p53 and ras gene alterations in human non-small cell lung cancers, with and without associated pulmonary asbestosis.
Asbestosis
k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
Asthenozoospermia
Involvement of sperm plasma membrane and cytoskeletal proteins in human male infertility.
Asthma
Arf6 exacerbates allergic asthma through cell-to-cell transmission of ASC inflammasomes.
Asthma
CDC42-related genes are upregulated in helper T cells from obese asthmatic children.
Asthma
Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.
Asthma
Functional Genomics of the Pediatric Obese Asthma Phenotype Reveal Enrichment of Rho-GTPase Pathways.
Asthma
Inhibition of p21-activated kinase 1 attenuates the cardinal features of asthma through suppressing the lymph node homing of dendritic cells.
Asthma
MicroRNAs and Their Therapeutic Potential for Human Diseases: MiR-133a and Bronchial Smooth Muscle Hyperresponsiveness in Asthma.
Asthma
Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
Asthma
RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?
Asthma
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Asthma
Type II alveolar epithelial cell-specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4.
Asthma
[Non-coding RNAs and bronchial smooth muscle hyperresponsiveness in allergic bronchial asthma].
Astrocytoma
Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.
Astrocytoma
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Astrocytoma
ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.
Astrocytoma
Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
Astrocytoma
H-Ras increases urokinase expression and cell invasion in genetically modified human astrocytes through Ras/Raf/MEK signaling pathway.
Astrocytoma
Implication of the small GTPase Rac1 in the generation of reactive oxygen species in response to beta-amyloid in C6 astroglioma cells.
Astrocytoma
Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras.
Astrocytoma
Insulin-like growth factor binding protein 2 promotes glioma development and progression.
Astrocytoma
Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1.
Astrocytoma
Targeting Ras-RAF-ERK and its Interactive Pathways as a Novel Therapy for Malignant Gliomas.
Astrocytoma
The regulation of RhoA at focal adhesions by StarD13 is important for astrocytoma cell motility.
Ataxia
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
Ataxia
Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
Atherosclerosis
A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis.
Atherosclerosis
Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo.
Atherosclerosis
Endothelial Rap1 (Ras-Association Proximate 1) Restricts Inflammatory Signaling to Protect From the Progression of Atherosclerosis.
Atherosclerosis
High glucose-induced upregulation of Rho / Rho-kinase via platelet-derived growth factor receptor-beta increases migration of aortic smooth muscle cells.
Atherosclerosis
Inhibition of Rac1 GTPase Decreases Vascular Oxidative Stress, Improves Endothelial Function, and Attenuates Atherosclerosis Development in Mice.
Atherosclerosis
Lack of mutations in K-ras codons 12 and 13 in human atherosclerotic lesions.
Atherosclerosis
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.
Atherosclerosis
[Transcriptional expression of oncogenes and Rb antioncogene in experimental atherosclerotic lesions]
Atrial Fibrillation
Cardiac Rac1 overexpression in mice creates a substrate for atrial arrhythmias characterized by structural remodelling.
Atrial Fibrillation
Identification of Co-expressed Genes Between Atrial Fibrillation and Stroke.
Atrial Fibrillation
Membrane translocation of small GTPase Rac1 and activation of STAT1 and STAT3 in pacing-induced sustained atrial fibrillation.
Atrial Fibrillation
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Atrial Fibrillation
Simvastatin attenuates the oxidative stress, endothelial thrombogenicity and the inducibility of atrial fibrillation in a rat model of ischemic heart failure.
Autoimmune Diseases
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Autoimmune Pancreatitis
Endoscopic ultrasound fine needle aspirate DNA analysis to differentiate malignant and benign pancreatic masses.
Autoimmune Pancreatitis
Frequent and Significant K-ras Mutation in the Pancreas, the Bile Duct, and the Gallbladder in Autoimmune Pancreatitis.
Autoimmune Pancreatitis
K-ras mutation in the major duodenal papilla and gastric and colonic mucosa in patients with autoimmune pancreatitis.
Autoimmune Pancreatitis
[IgG4-related sclerosing disease, including its relation to carcinogenesis].
Bacteremia
Escherichia coli ?-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia.
Bacteremia
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia.
Bacterial Infections
A Small GTPase, RhoA, Inhibits Bacterial Infection Through Integrin Mediated Phagocytosis in Invertebrates.
Bacterial Infections
Arabidopsis EF-Tu receptor enhances bacterial disease resistance in transgenic wheat.
Bacterial Infections
Enhancement of innate immune system in monocot rice by transferring the dicotyledonous elongation factor Tu receptor EFR.
Bacterial Infections
Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection.
Bacterial Infections
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes.
Bacterial Infections
Identification, annotation and expression analysis of 29 Rho GTPase genes from channel catfish (Ictalurus punctatus) after bacterial infections.
Bacterial Infections
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Bacterial Infections
Increased survival and reduced neutrophil infiltration of the liver in rab27a- but not munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.
Bacterial Infections
Role of the small GTPase Rap1 in signal transduction, cell dynamics and bacterial infection.
Bardet-Biedl Syndrome
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.
Bardet-Biedl Syndrome
Biochemical characterization of missense mutations in the Arf/Arl-family small GTPase Arl6 causing Bardet-Biedl syndrome.
Bardet-Biedl Syndrome
Crystal structure of the small GTPase Arl6/BBS3 from Trypanosoma brucei.
Bardet-Biedl Syndrome
High prevalence of Bardet-Biedl syndrome in La Réunion Island is due to a founder variant in ARL6/BBS3.
Bardet-Biedl Syndrome
Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8.
Bardet-Biedl Syndrome
IFT27, encoding a small GTPase component of IFT particles, is mutated in a consanguineous family with Bardet-Biedl syndrome.
Barrett Esophagus
Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
Barrett Esophagus
Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia.
Barrett Esophagus
K-ras codon 12 mutations of the super-minute dysplasia in Barrett's esophagus by DNA extraction using a microdissection method.
Barrett Esophagus
Malignant progression in Barrett's esophagus: pathology and molecular biology.
Bile Duct Neoplasms
Aberrations of the K-ras, p53, and APC genes in extrahepatic bile duct cancer.
Bile Duct Neoplasms
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Bile Duct Neoplasms
Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders.
Bile Duct Neoplasms
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
Bile Duct Neoplasms
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Biliary Atresia
Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver.
Biliary Tract Diseases
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Biliary Tract Neoplasms
Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction.
Biliary Tract Neoplasms
Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
Biliary Tract Neoplasms
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
Biliary Tract Neoplasms
K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
Biliary Tract Neoplasms
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
Biliary Tract Neoplasms
Mutations of p16Ink4/CDKN2 and p15Ink4B/MTS2 genes in biliary tract cancers.
Biliary Tract Neoplasms
p53 overexpression and K-ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer.
Biliary Tract Neoplasms
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Blast Crisis
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
Blast Crisis
High frequency of RAS oncogene mutation in chronic myeloid leukemia patients with myeloblastoma.
Blast Crisis
Ras oncogene mutations are rare late stage events in chronic myelogenous leukemia.
Blast Crisis
Southern blot analysis of Bcr, N-ras, H-ras, c-myc and myb proto-oncogenes in blast crisis of chronic myelogenous leukemia.
Blast Crisis
Structural insights into the activation of the RhoA GTPase by the lymphoid blast crisis (Lbc) oncoprotein.
Blister
Bleb Expansion in Migrating Cells Depends on Supply of Membrane from Cell Surface Invaginations.
Blister
Cdc42 expression in keratinocytes is required for the maintenance of the basement membrane in skin.
Blister
Developmental expression, co-localization and genetic interaction of exocyst component Sec15 with Rab11 during Drosophila development.
Blister
ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus.
Blister
Rab11 is required for cell adhesion, maintenance of cell shape and actin-cytoskeleton organization during Drosophila wing development.
Blister
The ADP-ribosylation domain of Pseudomonas aeruginosa ExoS is required for membrane bleb niche formation and bacterial survival within epithelial cells.
Blister
THE ANGIOTENSIN II TYPE 1 RECEPTOR INDUCES MEMBRANE BLEBBING BY COUPLING TO RHO A, RHO KINASE AND MYOSIN LIGHT CHAIN KINASE.
Blister
The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells.
Bone Diseases, Metabolic
SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity.
Bone Resorption
Aesculetin Inhibits Osteoclastic Bone Resorption through Blocking Ruffled Border Formation and Lysosomal Trafficking.
Bone Resorption
Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization.
Bone Resorption
Downregulation of small GTPase Rab7 impairs osteoclast polarization and bone resorption.
Bone Resorption
Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation.
Bone Resorption
Preservation of bone mass and structure in hibernating black bears (Ursus americanus) through elevated expression of anabolic genes.
Bone Resorption
Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.
Bone Resorption
SLIT2 inhibits osteoclastogenesis and bone resorption by suppression of Cdc42 activity.
Bone Resorption
Thienopyrimidine Bisphosphonate (ThPBP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase: Optimization and Characterization of the Mode of Inhibition.
Bowen's Disease
Arsenic-related Bowen's disease and paraquat-related skin cancerous lesions show no detectable ras and p53 gene alterations.
Brain Diseases
BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain.
Brain Diseases
De novo variants in RHOBTB2, an atypical Rho GTPase gene, cause epileptic encephalopathy.
Brain Diseases
Early infantile epileptic encephalopathy associated with the disrupted gene encoding Slit-Robo Rho GTPase activating protein 2 (SRGAP2).
Brain Diseases
Missense Variants in RHOBTB2 Cause a Developmental and Epileptic Encephalopathy in Humans, and Altered Levels Cause Neurological Defects in Drosophila.
Brain Diseases
Reversing synapse loss in Alzheimer's disease: rho-guanosine triphosphatases and insights from other brain disorders.
Brain Edema
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Brain Injuries
CID1067700, a late endosome GTPase Rab7 receptor antagonist, attenuates brain atrophy, improves neurologic deficits and inhibits reactive astrogliosis in rat ischemic stroke.
Brain Injuries
Down-regulation Cdc42 attenuates neuronal apoptosis through inhibiting MLK3/JNK3 cascade during ischemic reperfusion in rat hippocampus.
Brain Injuries
Protection of Oligodendrocytes Through Neuronal Overexpression of the Small GTPase Ras in Hyperoxia-Induced Neonatal Brain Injury.
Brain Injuries
SVCT2 Promotes Neural Stem/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke.
Brain Ischemia
Global brain ischemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translation initiation.
Brain Ischemia
Role of Rac1 GTPase in JNK signaling and delayed neuronal cell death following global cerebral ischemia.
Brain Ischemia
Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat.
Brain Neoplasms
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
Brain Neoplasms
Cerebral metastases as first symptom of cancer: a clinico-pathologic study.
Brain Neoplasms
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Brain Neoplasms
Glial tumors in the MNU rat model: induction of pure and mixed gliomas that do not require typical missense mutations of p53.
Brain Neoplasms
Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.
Brain Neoplasms
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
Breast Diseases
Immunocytochemical demonstration and significance of p21 ras family oncogene product in benign and malignant breast disease.
Breast Neoplasms
14-3-3? promotes breast cancer invasion and metastasis by inhibiting RhoGDI?.
Breast Neoplasms
3D structure generation, virtual screening and docking of human Ras-associated binding (Rab3A) protein involved in tumourigenesis.
Breast Neoplasms
?-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
Breast Neoplasms
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
Breast Neoplasms
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Breast Neoplasms
A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness.
Breast Neoplasms
A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen.
Breast Neoplasms
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Breast Neoplasms
Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer-Mediated Cytotoxicity.
Breast Neoplasms
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42.
Breast Neoplasms
Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells.
Breast Neoplasms
Additional characterization of a hexanucleotide polymorphic site in the first intron of human H-ras gene: comparative study of its alterations in non-small cell lung carcinomas and sporadic invasive breast carcinomas.
Breast Neoplasms
ADP Ribosylation Factor Like 2 (Arl2) Regulates Breast Tumor Aggressivity in Immunodeficient Mice.
Breast Neoplasms
ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells.
Breast Neoplasms
Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.
Breast Neoplasms
Association between Glycodelin and Aryl Hydrocarbon Receptor in Iranian Breast Cancer Patients: Impact of Environmental Endocrine Disrupting Chemicals.
Breast Neoplasms
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer.
Breast Neoplasms
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
Breast Neoplasms
BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer. An immunohistochemical study.
Breast Neoplasms
Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.
Breast Neoplasms
Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells.
Breast Neoplasms
cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation.
Breast Neoplasms
Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration.
Breast Neoplasms
CCL2/CCR2 chemokine signaling coordinates survival and motility of breast cancer cells through Smad3 and p42/44MAPK dependent mechanisms.
Breast Neoplasms
Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells.
Breast Neoplasms
Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.
Breast Neoplasms
Cdc42: an effector and regulator of ErbB1 as a strategic target in breast cancer therapy.
Breast Neoplasms
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Breast Neoplasms
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
Breast Neoplasms
Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
Breast Neoplasms
Clinical relevance of H-RAS, K-RAS, and N-RAS mRNA expression in primary breast cancer patients.
Breast Neoplasms
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential
Breast Neoplasms
Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential.
Breast Neoplasms
Cloning and sequencing of the 52K cathepsin D complementary deoxyribonucleic acid of MCF7 breast cancer cells and mapping on chromosome 11.
Breast Neoplasms
CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP.
Breast Neoplasms
Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer.
Breast Neoplasms
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
Breast Neoplasms
Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer.
Breast Neoplasms
DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1.
Breast Neoplasms
Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2.
Breast Neoplasms
Differential effects of Ca(2+) on bisphosphonate-induced growth inhibition in breast cancer and mesothelioma cells.
Breast Neoplasms
Differential expression and mutation of the ras family genes in human breast cancer.
Breast Neoplasms
DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway.
Breast Neoplasms
Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cells.
Breast Neoplasms
Effect of microRNA-206 on cytoskeleton remodelling by downregulating Cdc42 in MDA-MB-231 cells.
Breast Neoplasms
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Breast Neoplasms
Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated breast cancers.
Breast Neoplasms
Endometrial K-ras mutations in postmenopausal breast cancer patients treated with adjuvant tamoxifen or toremifene.
Breast Neoplasms
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
Breast Neoplasms
Enhanced intrinsic migration of aggressive breast cancer cells by inhibition of Rac1 GTPase.
Breast Neoplasms
ErbB2-enhanced invasiveness of H-Ras MCF10A breast cells requires MMP-13 and uPA upregulation via p38 MAPK signaling.
Breast Neoplasms
Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells.
Breast Neoplasms
Estrogen defines the dynamics and destination of transactivated EGF receptor in breast cancer cells: role of S1P? receptor and Cdc42.
Breast Neoplasms
Estrogen Regulates Vesicle Trafficking Gene Expression in EFF-3, EFM-19 and MCF-7 Breast Cancer Cells.
Breast Neoplasms
Evidence for Enhanced Exosome Production in Aromatase Inhibitor-Resistant Breast Cancer Cells.
Breast Neoplasms
Evidence of Rab3A expression, regulation of vesicle trafficking, and cellular secretion in response to heregulin in mammary epithelial cells.
Breast Neoplasms
Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer.
Breast Neoplasms
Expression of p21 ras gene products in breast cancer relates to histological types and to receptor and nodal status.
Breast Neoplasms
Farnesyl transferase inhibitor FTI-277 inhibits breast cell invasion and migration by blocking H-Ras activation.
Breast Neoplasms
FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression.
Breast Neoplasms
FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
Breast Neoplasms
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs.
Breast Neoplasms
Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
Breast Neoplasms
Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma.
Breast Neoplasms
Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells.
Breast Neoplasms
Genetic analysis of H-ras intron-1 polymorphic and variable tandem repeat regions in human breast cancer.
Breast Neoplasms
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Breast Neoplasms
Gliotoxin is a dual inhibitor of farnesyltransferase and geranylgeranyltransferase I with antitumor activity against breast cancer in vivo.
Breast Neoplasms
Glucan and resveratrol complex - possible synergistic effects on immune system.
Breast Neoplasms
Growth and motility inhibition of breast cancer cells by epidermal growth factor receptor degradation is correlated with inactivation of Cdc42.
Breast Neoplasms
H-ras dependent estrogenic effects of epidermal growth factor in the estrogen-independent breast cancer cell line MDA-MB-231.
Breast Neoplasms
H-ras gene amplification or mutation is not common in human primary breast cancer.
Breast Neoplasms
H-Ras induces Nrf2-Pin1 interaction: Implications for breast cancer progression.
Breast Neoplasms
H-ras, but not N-ras, induces an invasive phenotype in human breast epithelial cells: a role for MMP-2 in the H-ras-induced invasive phenotype.
Breast Neoplasms
Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.
Breast Neoplasms
HER-2/neu-Positive breast carcinoma: molecular concomitants by proteomic analysis and their therapeutic implications.
Breast Neoplasms
HER2/ErbB2-induced breast cancer cell migration and invasion require p120 catenin activation of Rac1 and Cdc42.
Breast Neoplasms
Heregulin beta1 promotes breast cancer cell proliferation through Rac/ERK-dependent induction of cyclin D1 and p21Cip1.
Breast Neoplasms
High Frequency of Codon 12 but not Codon 13 and 61 K-ras Gene Mutations in Invasive Ductal Carcinoma of Breast in a South Indian Population.
Breast Neoplasms
High glucose levels promote the proliferation of breast cancer cells through GTPases.
Breast Neoplasms
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
Breast Neoplasms
HOXC8 promotes breast tumorigenesis by transcriptionally facilitating cadherin-11 expression.
Breast Neoplasms
Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1.
Breast Neoplasms
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.
Breast Neoplasms
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis.
Breast Neoplasms
IBP regulates epithelial-to-mesenchymal transition and the motility of breast cancer cells via Rac1, RhoA and Cdc42 signaling pathways.
Breast Neoplasms
Identification of FDA-approved Drugs Targeting Breast Cancer Stem Cells Along With Biomarkers of Sensitivity.
Breast Neoplasms
Identification of h-ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.
Breast Neoplasms
IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling.
Breast Neoplasms
Immunohistochemical analysis reveals a protective effect of H-ras expression mediated via apoptosis in node-negative breast cancer patients.
Breast Neoplasms
Immunohistochemical detection of H-ras protooncoprotein p21 indicates favorable prognosis in node-negative breast cancer patients.
Breast Neoplasms
Immunohistochemical Staining for Ras-Related Protein 25 (RAB25) Associates with Luminal B Breast Cancer Subtype.
Breast Neoplasms
Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation.
Breast Neoplasms
Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells.
Breast Neoplasms
Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis.
Breast Neoplasms
Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer.
Breast Neoplasms
Influence of ARHGAP29 on the Invasion of Mesenchymal-Transformed Breast Cancer Cells.
Breast Neoplasms
Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.
Breast Neoplasms
Inhibition of silibinin on migration and adhesion capacity of human highly metastatic breast cancer cell line, MDA-MB-231, by evaluation of ?1-integrin and downstream molecules, Cdc42, Raf-1 and D4GDI.
Breast Neoplasms
Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.
Breast Neoplasms
Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance.
Breast Neoplasms
Invasion of breast cancer cells into collagen matrix requires TGF-? and Cdc42 signaling.
Breast Neoplasms
Involvement of ARHGEF10, GEF for RhoA, in Rab6/Rab8-mediating membrane traffic.
Breast Neoplasms
K-ras mutation in the endometrium of tamoxifen-treated breast cancer patients, with a comparison of tamoxifen and toremifene.
Breast Neoplasms
K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3.
Breast Neoplasms
KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2.
Breast Neoplasms
Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein.
Breast Neoplasms
Long non-coding RNA RACGAP1P promotes breast cancer invasion and metastasis via miR-345-5p/RACGAP1-mediated mitochondrial fission.
Breast Neoplasms
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Breast Neoplasms
Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-?/SMAD signaling.
Breast Neoplasms
Loss of Rho GDI{alpha} and Resistance to Tamoxifen via Effects on Estrogen Receptor {alpha}.
Breast Neoplasms
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.
Breast Neoplasms
Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer.
Breast Neoplasms
MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42.
Breast Neoplasms
Mammalian Actin-binding Protein-1/Hip-55 Interacts with FHL2 and Negatively Regulates Cell Invasion.
Breast Neoplasms
MDA-9/Syntenin (SDCBP) modulates small GTPases RhoA and Cdc42 via transforming growth factor ?1 to enhance epithelial-mesenchymal transition in breast cancer.
Breast Neoplasms
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
Breast Neoplasms
MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells.
Breast Neoplasms
MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c.
Breast Neoplasms
MicroRNA-192-5p inhibits migration of triple negative breast cancer cells and directly regulates Rho GTPase activating protein 19.
Breast Neoplasms
MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis.
Breast Neoplasms
MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1.
Breast Neoplasms
miR-376c-3p modulates the properties of breast cancer stem cells by targeting RAB2A.
Breast Neoplasms
miR-433 inhibits breast cancer cell growth via the MAPK signaling pathway by targeting Rap1a.
Breast Neoplasms
MKL1 Mediates TGF-? Induced RhoJ Transcription to Promote Breast Cancer Cell Migration and Invasion.
Breast Neoplasms
Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer.
Breast Neoplasms
Modulation of ERK5 is a novel mechanism by which Cdc42 regulates migration of breast cancer cells.
Breast Neoplasms
Molecular genetic characterization of tamoxifen-associated endometrial cancer.
Breast Neoplasms
Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.
Breast Neoplasms
Monitoring the Rab27 associated exosome pathway using nanoparticle tracking analysis.
Breast Neoplasms
Multiple Effects of a Novel Epothilone Analog on Cellular Processes and Signaling Pathways Regulated by Rac1 GTPase in the Human Breast Cancer Cells.
Breast Neoplasms
Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.
Breast Neoplasms
Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.
Breast Neoplasms
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
Breast Neoplasms
N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator.
Breast Neoplasms
Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer.
Breast Neoplasms
Neoadjuvant Therapy with Drug Arglabin for Breast Cancer with Expression of H-Ras Oncoproteins.
Breast Neoplasms
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
Breast Neoplasms
Newly formed E-cadherin contacts do not activate Cdc42 or induce filopodia protrusion in human keratinocytes1.
Breast Neoplasms
Nischarin is differentially expressed in rat brain and regulates neuronal migration.
Breast Neoplasms
Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.
Breast Neoplasms
Numerical analysis of intracellular amino acid profiles of breast cancer cells with K-Ras or PI3K mutation in response to kinase inhibitors.
Breast Neoplasms
Oncodevelopmental expression of--GlcNAc beta 1-6Man alpha 1-6Man beta 1--branched asparagine-linked oligosaccharides in murine tissues and human breast carcinomas.
Breast Neoplasms
Oncogene activation in malignant transformation: a study of H-ras in human breast cancer.
Breast Neoplasms
Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis.
Breast Neoplasms
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
Breast Neoplasms
Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.
Breast Neoplasms
PDZ and LIM domain protein 1(PDLIM1)/CLP36 promotes breast cancer cell migration, invasion and metastasis through interaction with ?-actinin.
Breast Neoplasms
Phloretin induces apoptosis in H-Ras MCF10A human breast tumor cells through the activation of p53 via JNK and p38 mitogen-activated protein kinase signaling.
Breast Neoplasms
Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?
Breast Neoplasms
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Breast Neoplasms
Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein.
Breast Neoplasms
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Breast Neoplasms
RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
Breast Neoplasms
RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.
Breast Neoplasms
Rab35 is required for Wnt5a/Dvl2-induced Rac1 activation and cell migration in MCF-7 breast cancer cells.
Breast Neoplasms
Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells.
Breast Neoplasms
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer.
Breast Neoplasms
RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment.
Breast Neoplasms
Ras p21 in breast tissue: associations with pathology and cellular localisation.
Breast Neoplasms
Ras stimulation of E2F activity and a consequent E2F regulation of integrin alpha6beta4 promote the invasion of breast carcinoma cells.
Breast Neoplasms
Recombinant anthrax lethal toxin inhibits cell motility and invasion in breast cancer cells through the dysregulation of Rho GTPases.
Breast Neoplasms
Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers.
Breast Neoplasms
Regions of H- and K-ras that provide organ specificity/potency in mammary cancer induction.
Breast Neoplasms
Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c.
Breast Neoplasms
Relationship between metastatic ability and H-ras oncogene expression in rat mammary cancer cells transfected with the v-H-ras oncogene.
Breast Neoplasms
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Breast Neoplasms
Rho GTPase Activating Protein 24 (ARHGAP24) Regulates the Anti-Cancer Activity of Sorafenib Against Breast Cancer MDA-MB-231 Cells via the Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway.
Breast Neoplasms
Rho-GTPase activating-protein 18: a biomarker associated with good prognosis in invasive breast cancer.
Breast Neoplasms
RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.
Breast Neoplasms
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Breast Neoplasms
RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.
Breast Neoplasms
Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of ?-Tocotrienol on Mammary Cancer Cell Migration and Invasion.
Breast Neoplasms
Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.
Breast Neoplasms
Shotgun proteomics coupled to nanoparticle-based biomarker enrichment reveals a novel panel of extracellular matrix proteins as candidate serum protein biomarkers for early-stage breast cancer detection.
Breast Neoplasms
Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins.
Breast Neoplasms
Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.
Breast Neoplasms
SP1 and STAT3 Functionally Synergize to Induce the RhoU Small GTPase and a Subclass of Non-canonical WNT Responsive Genes Correlating with Poor Prognosis in Breast Cancer.
Breast Neoplasms
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells.
Breast Neoplasms
STAT3 Stabilizes IKK? Protein through Direct Interaction in Transformed and Cancerous Human Breast Epithelial Cells.
Breast Neoplasms
Stretch Induces Invasive Phenotypes in Breast Cells Due to Activation of Aerobic-Glycolysis-Related Pathways.
Breast Neoplasms
Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae.
Breast Neoplasms
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy.
Breast Neoplasms
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
Breast Neoplasms
The Accumulation of Multiple Genetic Abnormalities in Individual Tumor Cells in Human Breast Cancers: Clinical Prognostic Implications
Breast Neoplasms
The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking.
Breast Neoplasms
The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells.
Breast Neoplasms
The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.
Breast Neoplasms
The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.
Breast Neoplasms
The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.
Breast Neoplasms
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Breast Neoplasms
The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.
Breast Neoplasms
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Breast Neoplasms
The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.
Breast Neoplasms
The Rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.
Breast Neoplasms
The secretory small GTPase Rab27B as a marker for breast cancer progression.
Breast Neoplasms
The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42.
Breast Neoplasms
The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors.
Breast Neoplasms
The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells.
Breast Neoplasms
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Breast Neoplasms
Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer.
Breast Neoplasms
Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.
Breast Neoplasms
Transforming growth factor (TGF)-beta in conjunction with H-ras activation promotes malignant progression of MCF10A breast epithelial cells.
Breast Neoplasms
Triptolide Inhibits Breast Cancer Cell Metastasis Through Inducing the Expression of miR-146a, a Negative Regulator of Rho GTPase.
Breast Neoplasms
Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies.
Breast Neoplasms
Use of molecular markers for predicting therapy response in cancer patients.
Breast Neoplasms
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
Breast Neoplasms
Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms.
Breast Neoplasms
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer.
Breast Neoplasms
WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells.
Breast Neoplasms
[Effects of Cdc42 overexpression on the estrogen-enhanced multidrug resistance in breast cancer cells].
Breast Neoplasms
[Let-7i reduces chemotherapy resistance in breast cancer cells through down-regulation of K-Ras and Bcl2 expression].
Breast Neoplasms
[Role of Rab23 in invasion and migration of human breast cancer Bcap-37 cells].
Brenner Tumor
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
Bronchitis, Chronic
Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Burkholderia Infections
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Carcinogenesis
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
Carcinogenesis
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
Carcinogenesis
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
Carcinogenesis
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
Carcinogenesis
A label-free colorimetric isothermal cascade amplification for the detection of disease-related nucleic acids based on double-hairpin molecular beacon.
Carcinogenesis
A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice.
Carcinogenesis
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
Carcinogenesis
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
Carcinogenesis
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Carcinogenesis
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
Carcinogenesis
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
Carcinogenesis
A subset of lung adenocarcinomas and atypical adenomatous hyperplasia-associated foci are genotypically related: an EGFR, HER2, and K-ras mutational analysis.
Carcinogenesis
Abberant crypt foci -- importance in colorectal carcinogenesis and expression of p53 and mdm2: a changing concept.
Carcinogenesis
Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation.
Carcinogenesis
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma.
Carcinogenesis
Absence of p53 mutations in methylnitrosourea-induced mammary tumors in rats.
Carcinogenesis
Absence of point mutation in codons 12 and 13 of K-RAS oncogene in HPV-associated high grade dysplasia and squamous cell cervical carcinoma.
Carcinogenesis
ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.
Carcinogenesis
ACB-PCR measurement of spontaneous and furan-induced H-ras Codon 61 CAA to CTA and CAA to AAA mutation in B6C3F1 mouse liver.
Carcinogenesis
Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells.
Carcinogenesis
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Carcinogenesis
Activation of K-ras in aflatoxin B1-induced lung tumors from AC3F1 (A/J x C3H/HeJ) mice.
Carcinogenesis
Activin type II receptor restoration in ACVR2-deficient colon cancer cells induces transforming growth factor-beta response pathway genes.
Carcinogenesis
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Carcinogenesis
Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice.
Carcinogenesis
Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium.
Carcinogenesis
Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis.
Carcinogenesis
Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma.
Carcinogenesis
Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.
Carcinogenesis
An attempt to isolate genes responsible for spontaneous and experimental metastasis in the mouse model.
Carcinogenesis
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Carcinogenesis
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Carcinogenesis
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Carcinogenesis
Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice.
Carcinogenesis
Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines.
Carcinogenesis
Antisera to the variable region of ras oncogene proteins, and specific detection of H-ras expression in an experimental model of chemical carcinogenesis.
Carcinogenesis
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
Carcinogenesis
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
Carcinogenesis
Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.
Carcinogenesis
Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.
Carcinogenesis
Author Correction: The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Carcinogenesis
Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model.
Carcinogenesis
Bmi-1 Cooperates with H-Ras to Transform Human Mammary Epithelial Cells via Dysregulation of Multiple Growth-Regulatory Pathways.
Carcinogenesis
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Carcinogenesis
Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.
Carcinogenesis
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
Carcinogenesis
Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells.
Carcinogenesis
Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma.
Carcinogenesis
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
Carcinogenesis
Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.
Carcinogenesis
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Carcinogenesis
Cellular kinetics and gene mutations in gallbladder mucosa with an anomalous junction of pancreaticobiliary duct.
Carcinogenesis
Chemoprevention by pravastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, of N-methyl-N-nitrosourea-induced colon carcinogenesis in F344 rats.
Carcinogenesis
Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung.
Carcinogenesis
Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
Carcinogenesis
CircHIPK3 Promotes Thyroid Cancer Tumorigenesis and Invasion through the Mirna-338-3p/RAB23 Axis.
Carcinogenesis
Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway.
Carcinogenesis
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Carcinogenesis
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Carcinogenesis
Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection.
Carcinogenesis
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Carcinogenesis
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
Carcinogenesis
Codon 12 region of mouse K-ras gene is the site for in vitro binding of transcription factors GATA-6 and NF-Y.
Carcinogenesis
Coincidental alterations of p16INK4A/CDKN2 and other genes in human lung cancer cell lines.
Carcinogenesis
Combined identification of LncRNA CCAT1 and SOX2OT in serum as an effective screening for non-small cell lung cancer.
Carcinogenesis
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
Carcinogenesis
Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1? pathway to predict survival in resectable pancreatic cancer.
Carcinogenesis
Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value.
Carcinogenesis
Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients.
Carcinogenesis
Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.
Carcinogenesis
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Carcinogenesis
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice.
Carcinogenesis
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
Carcinogenesis
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.
Carcinogenesis
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
Carcinogenesis
CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.
Carcinogenesis
Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1.
Carcinogenesis
Curcumin Inhibits COPD-Like Airway Inflammation and Lung Cancer Progression in Mice.
Carcinogenesis
Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.
Carcinogenesis
Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation.
Carcinogenesis
Cytoskeletal modification of Rho guanine nucleotide exchange factor activity: identification of a Rho guanine nucleotide exchange factor as a binding partner for Sept9b, a mammalian septin.
Carcinogenesis
Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Carcinogenesis
Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
Carcinogenesis
Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Carcinogenesis
Detection of activated proto-oncogenes in N-nitrosodiethylamine-induced liver tumors: a comparison between B6C3F1 mice and Fischer 344 rats.
Carcinogenesis
Detection of genetic alterations in the p53 suppressor gene and the K-ras oncogene among different grades of dysplasia in patients with colorectal adenomas.
Carcinogenesis
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis.
Carcinogenesis
Detection of HPV and ras gene mutations in cervical smears from female genital lesions.
Carcinogenesis
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Carcinogenesis
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
Carcinogenesis
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Carcinogenesis
Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer.
Carcinogenesis
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Carcinogenesis
Diabetes enhances the expression of H-ras and suppresses the expression of EGFR leading to increased cell proliferation.
Carcinogenesis
Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Carcinogenesis
Diallyl sulfide enhances azoxymethane-induced preneoplasia in Fischer 344 rat colon.
Carcinogenesis
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
Carcinogenesis
Differences in carcinogenesis by the length of carcinogen exposure period in rat colon.
Carcinogenesis
Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
Carcinogenesis
Differential expression and mutation of the ras family genes in human breast cancer.
Carcinogenesis
Differential Expression of IL-17, 22 and 23 in the Progression of Colorectal Cancer in Patients with K-ras Mutation: Ras Signal Inhibition and Crosstalk with GM-CSF and IFN-?.
Carcinogenesis
Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.
Carcinogenesis
Direct and Indirect Anticancer Activity of Plant-Derived Alkaloid Conophylline.
Carcinogenesis
Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.
Carcinogenesis
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Carcinogenesis
DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma.
Carcinogenesis
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
Carcinogenesis
Down-regulated expression of RhoA in human conventional renal cell carcinoma.
Carcinogenesis
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Carcinogenesis
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Carcinogenesis
Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53.
Carcinogenesis
Early detection of cancer-associated gene alterations in DNA isolated from rat feces during intestinal tumor-induction with 1,2-dimethylhydrazine.
Carcinogenesis
Effect of increased expression of both ras-related C3 botulinum toxin substrate 1 and p21-activated kinase 1 in patients with N0M0 upper urinary tract urothelial carcinoma and cancer-free surgical margins.
Carcinogenesis
Effect of Jinguo Weikang Capsule () on proto-oncogene expression of gastric mucosa in rats with gastric precancerous lesions.
Carcinogenesis
Effects of N-methyl-N'-nitro-N-nitrosoguanidine on the human colorectal polyps consecutively maintained in SCID mice.
Carcinogenesis
Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma.
Carcinogenesis
Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung--importance of mouse strain.
Carcinogenesis
Endometrial K-ras mutations in postmenopausal breast cancer patients treated with adjuvant tamoxifen or toremifene.
Carcinogenesis
Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma.
Carcinogenesis
Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
Carcinogenesis
Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies.
Carcinogenesis
Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion.
Carcinogenesis
Epithelial carcinogenesis in the mouse: correlating the genetics and the biology.
Carcinogenesis
Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.
Carcinogenesis
Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells.
Carcinogenesis
Eugenol restricts DMBA croton oil induced skin carcinogenesis in mice: downregulation of c-Myc and H-ras, and activation of p53 dependent apoptotic pathway.
Carcinogenesis
Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.
Carcinogenesis
Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.
Carcinogenesis
Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis.
Carcinogenesis
Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation.
Carcinogenesis
Expression of ets-1 is not affected by N-ras or H-ras during oral oncogenesis.
Carcinogenesis
Expression of Hras-p21 and keratin K13 in UVR-induced skin tumors in Sencar mice.
Carcinogenesis
Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders.
Carcinogenesis
Expression of p21 ras protein as a prognostic factor in papillary thyroid cancer.
Carcinogenesis
Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector.
Carcinogenesis
Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase.
Carcinogenesis
Failure of catalase to protect against aflatoxin B1-induced mouse lung tumorigenicity.
Carcinogenesis
Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
Carcinogenesis
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Carcinogenesis
Fitness of unregulated human Ras mutants modeled by implementing computational mutagenesis and machine learning techniques.
Carcinogenesis
Frequency and clinicopathology associations of K-ras mutations in colorectal cancer in a northeast Mexican population.
Carcinogenesis
Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal adenocarcinomas from Taiwan.
Carcinogenesis
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Carcinogenesis
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Carcinogenesis
Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Carcinogenesis
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
Carcinogenesis
Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis
FSH receptor binding inhibitor depresses carcinogenesis of ovarian cancer via decreasing levels of K-Ras, c-Myc and FSHR.
Carcinogenesis
Galectin-8 binds to the Farnesylated C-terminus of K-Ras4B and Modifies Ras/ERK Signaling and Migration in Pancreatic and Lung Carcinoma Cells.
Carcinogenesis
Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
Carcinogenesis
Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Carcinogenesis
Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
Carcinogenesis
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Carcinogenesis
Genetic analysis of H-ras intron-1 polymorphic and variable tandem repeat regions in human breast cancer.
Carcinogenesis
Genetic and cellular changes in colorectal cancer: proposed targets of chemopreventive agents.
Carcinogenesis
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.
Carcinogenesis
Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions.
Carcinogenesis
Genomic instability and colon carcinogenesis: from the perspective of genes.
Carcinogenesis
Genomic profiles of colorectal carcinoma with liver metastases and newly identified fusion genes.
Carcinogenesis
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
Carcinogenesis
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Carcinogenesis
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Carcinogenesis
Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes.
Carcinogenesis
H-ras activation and ras p21 expression in bladder tumors induced in F344/NCr rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis
H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.
Carcinogenesis
H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: comparison of acute and chronic toxicity in rats.
Carcinogenesis
H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
Carcinogenesis
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Carcinogenesis
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
Carcinogenesis
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
Carcinogenesis
Hepatocellular Carcinomas in B6C3F1 Mice Treated with Ginkgo biloba Extract for Two Years Differ from Spontaneous Liver Tumors in Cancer Gene Mutations and Genomic Pathways.
Carcinogenesis
Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.
Carcinogenesis
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
Carcinogenesis
High frequency of K-ras mutations in biliary duct carcinomas of cases with a long common channel in the papilla of Vater.
Carcinogenesis
High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions.
Carcinogenesis
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
Carcinogenesis
HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis.
Carcinogenesis
Histological and genetic changes in malignant transformation of gallbladder adenoma.
Carcinogenesis
Human papillomavirus 16 (HPV16) enhances tumor growth and cancer stemness of HPV-negative oral/oropharyngeal squamous cell carcinoma cells via miR-181 regulation.
Carcinogenesis
Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature.
Carcinogenesis
Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
Carcinogenesis
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Carcinogenesis
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
Carcinogenesis
Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.
Carcinogenesis
II. Effect of n-3 and n-6 fatty acids on mammary H-ras expression and PGE2 levels in DMBA-treated rats.
Carcinogenesis
Immortalized bovine pancreatic duct cells become tumorigenic after transfection with mutant k-ras.
Carcinogenesis
Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas.
Carcinogenesis
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Carcinogenesis
Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Carcinogenesis
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice.
Carcinogenesis
Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.
Carcinogenesis
In vitro carcinogenesis of hamster pancreatic duct cells: cellular and molecular alterations.
Carcinogenesis
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.
Carcinogenesis
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Carcinogenesis
Incidence of P53 and K-ras alterations in ovarian mucinous and serous tumors.
Carcinogenesis
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
Carcinogenesis
Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
Carcinogenesis
Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke.
Carcinogenesis
Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid.
Carcinogenesis
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Carcinogenesis
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Carcinogenesis
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Carcinogenesis
Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved.
Carcinogenesis
Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.
Carcinogenesis
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Carcinogenesis
Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis.
Carcinogenesis
Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.
Carcinogenesis
Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer.
Carcinogenesis
Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
Carcinogenesis
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Carcinogenesis
Interplay between estrogen and Stat3/NF-?B-driven immunomodulation in lung cancer.
Carcinogenesis
Interplay between oncogenic K-Ras and wild-type H-Ras in Caco2 cell transformation.
Carcinogenesis
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Carcinogenesis
Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.
Carcinogenesis
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.
Carcinogenesis
Involvement of APC and K-ras mutation in non-polypoid colorectal tumorigenesis.
Carcinogenesis
Involvement of PLC?-PKC? pathway in human BIU-87 bladder cancer cell proliferation.
Carcinogenesis
K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.
Carcinogenesis
K-ras activation in colorectal tumors from patients with familial polyposis coli.
Carcinogenesis
K-Ras and ?-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
Carcinogenesis
K-ras and p53 alterations in genomic DNA and transcripts of human pancreatic adenocarcinoma cell lines.
Carcinogenesis
K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
Carcinogenesis
K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study.
Carcinogenesis
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
Carcinogenesis
K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Carcinogenesis
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
Carcinogenesis
K-ras codon 12 mutation determines the polypoid growth of colorectral cancer.
Carcinogenesis
K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
Carcinogenesis
K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
Carcinogenesis
K-ras gene mutations in intrahepatic bile duct tumors of Syrian golden hamsters.
Carcinogenesis
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
Carcinogenesis
K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.
Carcinogenesis
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
Carcinogenesis
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
Carcinogenesis
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
Carcinogenesis
K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
Carcinogenesis
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Carcinogenesis
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma.
Carcinogenesis
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
Carcinogenesis
K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
Carcinogenesis
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
Carcinogenesis
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
Carcinogenesis
K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas.
Carcinogenesis
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
Carcinogenesis
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
Carcinogenesis
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
Carcinogenesis
K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
Carcinogenesis
K-ras Mutations in Lung Tumors from NNK-treated Mice with Lipopolysaccharide-elicited Lung Inflammation.
Carcinogenesis
K-ras mutations in lung tumors from p53 mutant mice exposed to cigarette smoke.
Carcinogenesis
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
Carcinogenesis
K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.
Carcinogenesis
K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients with left-sided colorectal carcinoma.
Carcinogenesis
K-ras oncogene mutation in cancer and precancerous lesions of the gallbladder.
Carcinogenesis
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Carcinogenesis
K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid.
Carcinogenesis
K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer.
Carcinogenesis
K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma.
Carcinogenesis
K-ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction.
Carcinogenesis
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
Carcinogenesis
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
Carcinogenesis
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
Carcinogenesis
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
Carcinogenesis
K-Ras stabilization by estrogen via PKC? is involved in endometrial tumorigenesis.
Carcinogenesis
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
Carcinogenesis
KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.
Carcinogenesis
KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer.
Carcinogenesis
Large Bowel Genetic Background and Inflammatory Processes in Carcinogenesis--Systematic Review.
Carcinogenesis
Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254.
Carcinogenesis
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
Carcinogenesis
Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
Carcinogenesis
Lin28 promotes transformation and is associated with advanced human malignancies.
Carcinogenesis
Long-term follow-up of patients with a clinically benign extrahepatic biliary stenosis and K-ras mutation in endobiliary brush cytology.
Carcinogenesis
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Carcinogenesis
Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
Carcinogenesis
Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression.
Carcinogenesis
Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Carcinogenesis
Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years.
Carcinogenesis
LPS-induced nuclear translocation of RhoA is dependent on NF-?B in the human lung cancer cell line A549.
Carcinogenesis
M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.
Carcinogenesis
Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers.
Carcinogenesis
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Carcinogenesis
Mechanism of bracken fern carcinogenesis: evidence for H-ras activation via initial adenine alkylation by ptaquiloside.
Carcinogenesis
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Carcinogenesis
Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update.
Carcinogenesis
Metastasis suppressors Nm23H1 and Nm23H2 differentially regulate neoplastic transformation and tumorigenesis.
Carcinogenesis
Micro ribonucleic acid-93 promotes oncogenesis of cervical cancer by targeting RAB11 family interacting protein 1.
Carcinogenesis
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
Carcinogenesis
MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells.
Carcinogenesis
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Carcinogenesis
Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
Carcinogenesis
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.
Carcinogenesis
miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer.
Carcinogenesis
miR-200b/c-RAP1B axis represses tumorigenesis and malignant progression of papillary thyroid carcinoma through inhibiting the NF-?B/Twist1 pathway.
Carcinogenesis
MiroRNA-188 Acts as Tumor Suppressor in Non-Small-Cell Lung Cancer by Targeting MAP3K3.
Carcinogenesis
Molecular and biological analysis of carcinoma of the small intestine: beta-catenin gene mutation by interstitial deletion involving exon 3 and replication error phenotype.
Carcinogenesis
Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Carcinogenesis
Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane.
Carcinogenesis
Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40.
Carcinogenesis
Molecular characterisation of the small GTPase CDC42 in the ectomycorrhizal fungus Tuber borchii Vittad.
Carcinogenesis
Molecular dynamics simulations of Gly-12-->Val mutant of p21(ras): dynamic inhibition mechanism.
Carcinogenesis
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
Carcinogenesis
Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.
Carcinogenesis
Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.
Carcinogenesis
Molecular pathogenesis of endometriosis-associated clear cell carcinoma of the ovary (review).
Carcinogenesis
Molecular screening for somatic mutations in corticotropic adenomas of dogs with pituitary-dependent hyperadrenocorticism.
Carcinogenesis
Morphologic change and elevation of cortisol secretion in cultured human normal adrenocortical cells caused by mutant p21K-ras protein.
Carcinogenesis
Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.
Carcinogenesis
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Carcinogenesis
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Carcinogenesis
Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis.
Carcinogenesis
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Carcinogenesis
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Carcinogenesis
Mutation of beta-catenin does not coexist with K-ras mutation in colorectal tumorigenesis.
Carcinogenesis
Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.
Carcinogenesis
Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.
Carcinogenesis
Mutational analysis of the BRAF gene in colorectal mucinous carcinoma in association with histological configuration.
Carcinogenesis
Mutational and epigenetic evidence for independent pathways for lung adenocarcinomas arising in smokers and never smokers.
Carcinogenesis
Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.
Carcinogenesis
Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
Carcinogenesis
Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis.
Carcinogenesis
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Carcinogenesis
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Carcinogenesis
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Carcinogenesis
Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis.
Carcinogenesis
Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.
Carcinogenesis
Neoplastic transformation of rat colon epithelial cells by expression of activated human K-ras.
Carcinogenesis
NF-kappa B is required for H-ras oncogene induced abnormal cell proliferation and tumorigenesis.
Carcinogenesis
NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.
Carcinogenesis
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
Carcinogenesis
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Carcinogenesis
Non-covalent interactions of the carcinogen (+)-anti-BPDE with exon 1 of the human K-ras proto-oncogene.
Carcinogenesis
Non-involvement of the K-ras mutation in colon carcinogenesis promoted by dietary deoxycholate in azoxymethane-treated rats.
Carcinogenesis
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.
Carcinogenesis
Novel approach to abuse the hyperactive K-Ras pathway for adenoviral gene therapy of colorectal cancer.
Carcinogenesis
Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
Carcinogenesis
Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
Carcinogenesis
Nuclear factor-?B signaling pathway is involved in phospholipase C?-regulated proliferation in human renal cell carcinoma cells.
Carcinogenesis
Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.
Carcinogenesis
Oct4 and Nanog Expression Is Associated With Early Stages of Pancreatic Carcinogenesis.
Carcinogenesis
Oncogenesis and the Clinical Significance of K-ras in Pancreatic Adenocarcinoma.
Carcinogenesis
Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
Carcinogenesis
Oncogenic K-ras drives cell cycle progression and phenotypic conversion of primary pancreatic duct epithelial cells.
Carcinogenesis
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
Carcinogenesis
Oncosuppressor methylation: A possible key role in colon metastatic progression.
Carcinogenesis
p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.
Carcinogenesis
p21-Activated protein kinases and their emerging roles in glucose homeostasis.
Carcinogenesis
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
Carcinogenesis
p53 and ras gene expression in human esophageal cancer and Barrett's epithelium: a prospective study.
Carcinogenesis
p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinogenesis
p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Carcinogenesis
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Carcinogenesis
Pathology and proliferative activity of renal-cell carcinomas (RCCS) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine.
Carcinogenesis
Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer.
Carcinogenesis
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Carcinogenesis
Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop.
Carcinogenesis
Polychlorinated biphenyls promote 1-nitropyrene-induced lung tumorigenesis without the induction of K-ras gene mutation in A/J mice.
Carcinogenesis
Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer.
Carcinogenesis
Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice.
Carcinogenesis
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Carcinogenesis
Prognostic significance of immunohistochemical RhoA expression on survival in pancreatic ductal adenocarcinoma: a high-throughput analysis.
Carcinogenesis
Prognostic Significance of K- ras Codon 12 Mutation in Patients with Resected Gallbladder Cancer.
Carcinogenesis
Proline isomerisation as a novel regulatory mechanism for p38MAPK activation and functions.
Carcinogenesis
Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Carcinogenesis
Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers.
Carcinogenesis
Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.
Carcinogenesis
Promotion of Lung Carcinogenesis by COPD-like Airway Inflammation in a K-ras Induced Mouse Model.
Carcinogenesis
Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
Carcinogenesis
PTEN loss and activation of K-RAS and ?-catenin cooperate to accelerate prostate tumourigenesis.
Carcinogenesis
Rab33A: Characterization, Expression, and Suppression by Epigenetic Modification.
Carcinogenesis
Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame.
Carcinogenesis
RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts.
Carcinogenesis
RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation.
Carcinogenesis
Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
Carcinogenesis
Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model.
Carcinogenesis
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Carcinogenesis
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts.
Carcinogenesis
Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis.
Carcinogenesis
Recent advances in understanding the antineoplastic mechanisms of farnesyltransferase inhibitors.
Carcinogenesis
Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
Carcinogenesis
Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.
Carcinogenesis
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.
Carcinogenesis
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
Carcinogenesis
Regulation of proto-oncogene transcription, cell proliferation, and tumorigenesis in mice by PSF protein and a VL30 noncoding RNA.
Carcinogenesis
Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction.
Carcinogenesis
Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.
Carcinogenesis
Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
Carcinogenesis
Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma.
Carcinogenesis
Remote partial gastrectomy as a risk factor for pancreatic cancer: potential for preventive strategies.
Carcinogenesis
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
Carcinogenesis
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Carcinogenesis
Restored expression of transforming growth factor beta type II receptor in k-ras-transformed thyroid cells, TGF beta-resistant, reverts their malignant phenotype.
Carcinogenesis
Retinoblastoma protein (pRB) was significantly phosphorylated through a Ras-to-MAPK pathway in mutant K-ras stably transfected human adrenocortical cells.
Carcinogenesis
Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity.
Carcinogenesis
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification.
Carcinogenesis
Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating ?-Catenin Signaling.
Carcinogenesis
Rho?associated kinase inhibitor, Y?27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
Carcinogenesis
RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway.
Carcinogenesis
ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences.
Carcinogenesis
Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines.
Carcinogenesis
Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
Carcinogenesis
Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
Carcinogenesis
Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
Carcinogenesis
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
Carcinogenesis
Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics.
Carcinogenesis
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
Carcinogenesis
Similar incidence of K-ras mutations in lung carcinomas of FVB/N mice and FVB/N mice carrying a mutant p53 transgene.
Carcinogenesis
Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents.
Carcinogenesis
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Carcinogenesis
Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.
Carcinogenesis
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Carcinogenesis
Stimulated human leukocytes cause activating mutations in the K-ras protooncogene.
Carcinogenesis
Studies on clinicopathological features of lung cancer patients with K-ras/p53 gene alterations: comparison between younger and older groups.
Carcinogenesis
Study of the correlation between H-ras mutation and primary hepatocellular carcinoma.
Carcinogenesis
Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.
Carcinogenesis
SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways.
Carcinogenesis
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Carcinogenesis
Synergistic effect of MNU and DMBA in mammary carcinogenesis and H-ras activation in female Sprague-Dawley rats.
Carcinogenesis
Systemic activation of K-ras rapidly induces gastric hyperplasia and metaplasia in mice.
Carcinogenesis
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Carcinogenesis
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
Carcinogenesis
Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells.
Carcinogenesis
Tea polyphenols can restrict benzo[a]pyrene-induced lung carcinogenesis by altered expression of p53-associated genes and H-ras, c-myc and cyclin D1.
Carcinogenesis
Telomeric repeat-length alterations in colorectal carcinoma are associated with loss of heterozygosity and point mutation in p53 gene.
Carcinogenesis
Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele.
Carcinogenesis
The activation of K-ras gene at an early stage of lung tumorigenesis in mice.
Carcinogenesis
The alternative H-ras protein p19 displays properties of a negative regulator of p21Ras.
Carcinogenesis
The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.
Carcinogenesis
The cell cycle regulator Ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells.
Carcinogenesis
The detection of chemically initiated cells having the mutation of K-ras gene at an early stage of lung carcinogenesis in mice.
Carcinogenesis
The deubiquitinase USP16 functions as an oncogenic factor in K-RAS-driven lung tumorigenesis.
Carcinogenesis
The dual functions of Rab11 and Rab35 GTPases-regulation of cell division and promotion of tumorigenicity.
Carcinogenesis
The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation.
Carcinogenesis
The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mice.
Carcinogenesis
The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Carcinogenesis
The frequency and spectrum of K-ras mutations among Iraqi patients with sporadic colorectal carcinoma.
Carcinogenesis
The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis.
Carcinogenesis
The inhibitory effect of vitamin E on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA injury and the fixation of the DNA injury in mouse lungs.
Carcinogenesis
The inhibitory effect of vitamin E on K-ras mutation at an early stage of lung carcinogenesis in mice.
Carcinogenesis
The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis.
Carcinogenesis
The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.
Carcinogenesis
The Long Intergenic Noncoding RNA 00707 Promotes Lung Adenocarcinoma Cell Proliferation and Migration by Regulating Cdc42.
Carcinogenesis
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-?B and RalB signaling pathways.
Carcinogenesis
The mutant K-ras oncogene causes pancreatic periductal lymphocytic infiltration and gastric mucous neck cell hyperplasia in transgenic mice.
Carcinogenesis
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
Carcinogenesis
The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.
Carcinogenesis
The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer.
Carcinogenesis
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
Carcinogenesis
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Carcinogenesis
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Carcinogenesis
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
Carcinogenesis
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.
Carcinogenesis
The TGF-{beta} co-receptor endoglin modulates the expression and transforming potential of H-Ras.
Carcinogenesis
Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
Carcinogenesis
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Carcinogenesis
Transforming growth factor-?-stimulated clone-22 is a negative-feedback regulator of Ras?/?Raf signaling: Implications for tumorigenesis.
Carcinogenesis
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Carcinogenesis
Translation-dependent mechanisms lead to PML upregulation and mediate oncogenic K-RAS induced cellular senescence.
Carcinogenesis
Treatment with lovastatin, cholestyramine or niacin alters K-ras membrane association in mouse lung in a strain-dependent manner: results in females.
Carcinogenesis
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
Carcinogenesis
Tumorigenesis of K-ras mutation in human endometrial carcinoma via upregulation of estrogen receptor.
Carcinogenesis
Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.
Carcinogenesis
Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients.
Carcinogenesis
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Carcinogenesis
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Carcinogenesis
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Carcinogenesis
Variant mutational activation of the K-ras oncogene in renal mesenchymal tumors induced in newborn F344 rats by methyl(methoxymethyl)nitrosamine.
Carcinogenesis
Variation in K-ras codon 12 point mutation rate with histological atypia within individual colorectal tumors.
Carcinogenesis
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
Carcinogenesis
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Carcinogenesis
Wnt/beta-catenin/tcf signaling: a critical pathway in gastrointestinal tumorigenesis.
Carcinogenesis
[Activation of proto-oncogenes induced by MNNG on primary culture of human gastric epithelium and immortalized human gastric epithelial cell line]
Carcinogenesis
[Alteration of the K-ras and p16/CDKN2 gene in endocrine pancreatic carcinomas]
Carcinogenesis
[Detection of H-ras and K-ras in tumors of gastrointestinal-pancreatic system]
Carcinogenesis
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
Carcinogenesis
[Diagnostic and oncologic updating on gallbladder papilloma. Personal experience and review of the literature]
Carcinogenesis
[Differential genetic pathway of duct and acinar carcinomas of the pancreas]
Carcinogenesis
[Effect of PCBs on mouse lung tumorigenesis induced by 1-nitropyrene: a preliminary report]
Carcinogenesis
[Effect of shRNA-mediated CDC42 knockdown on morphology of colorectal cancer cells in vitro].
Carcinogenesis
[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
Carcinogenesis
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
Carcinogenesis
[Genetic alterations and transformations in development and establishment of uterine endometrial carcinomas]
Carcinogenesis
[Identification analysis of eukaryotic expression plasmid Rap2a and its effect on the migration of lung cancer cells].
Carcinogenesis
[Influence of compensatory hepatocyte proliferation on the carcinogenesis of N-nitrosodimethylamine]
Carcinogenesis
[Microdissection and PCR-SSCP detected mutation and expression of p53 and K-ras gene in carcinogenesis and development of induced rat lung carcinoma]
Carcinogenesis
[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
Carcinogenesis
[Multiple gene alterations involved in the processor of human gastric carcinogenesis]
Carcinogenesis
[Pulmonary carcinogenesis susceptibility-associated single-nucleotide polymorphisms in K-ras intron 2 affect the binding of factor Gata-6 but not gene expression]
Carcinogenesis
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
Carcinogenesis
[Study of 8-OH-dG and its correlation with several cancer related gene in lung cancer tissues]
Carcinogenesis
[The mouse ovarian surface epithelium cells (MOSE) transformation induced by c-myc/K-ras in]
Carcinogenesis
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
Carcinoid Tumor
Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women.
Carcinoid Tumor
Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors.
Carcinoid Tumor
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Carcinoid Tumor
Morphological-histochemical study of intestinal carcinoids and K-ras mutation analysis in appendiceal carcinoids.
Carcinoid Tumor
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
Carcinoid Tumor
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Carcinoid Tumor
[Detection of H-ras and K-ras in tumors of gastrointestinal-pancreatic system]
Carcinoid Tumor
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Carcinoma
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Carcinoma
A clinicopathologic and immunohistochemical study of 35 anaplastic carcinomas of the pancreas with a review of the literature.
Carcinoma
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
Carcinoma
A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas.
Carcinoma
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
Carcinoma
A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma.
Carcinoma
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
Carcinoma
A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses.
Carcinoma
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
Carcinoma
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
Carcinoma
A novel radioresistant mechanism of galectin-1 mediated by H-Ras-dependent pathways in cervical cancer cells.
Carcinoma
A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma.
Carcinoma
A prospective study of detection of pancreatic carcinoma by combined plasma K-ras mutations and serum CA19-9 analysis.
Carcinoma
A recombinantly tailored ?-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer.
Carcinoma
A relationship between K-ras gene mutations and some clinical and histologic variables in patients with primary colorectal carcinoma.
Carcinoma
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Carcinoma
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Carcinoma
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Carcinoma
Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.
Carcinoma
Absence of point mutation in codons 12 and 13 of K-RAS oncogene in HPV-associated high grade dysplasia and squamous cell cervical carcinoma.
Carcinoma
Absence of ras oncogene activation in rat urinary bladder carcinomas induced by N-methyl-N-nitrosourea or N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinoma
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Carcinoma
Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population.
Carcinoma
Activated H-ras transforms rat intestinal epithelial cells with expression of alpha-TGF.
Carcinoma
Activated K-ras is involved in regulation of integrin expression in human colon carcinoma cells.
Carcinoma
Activated Rac1 selectively up-regulates the expression of integrin alpha6beta4 and induces cell adhesion and membrane ruffles of nonadherent colon cancer Colo201 cells.
Carcinoma
Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma.
Carcinoma
Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
Carcinoma
Activation of H-Ras and Rac1 correlates with epidermal growth factor-induced invasion in Hs578T and MDA-MB-231 breast carcinoma cells.
Carcinoma
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinoma
Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.
Carcinoma
Additional characterization of a hexanucleotide polymorphic site in the first intron of human H-ras gene: comparative study of its alterations in non-small cell lung carcinomas and sporadic invasive breast carcinomas.
Carcinoma
Adenocarcinoma arising in gastric heterotopic pancreas: clinicopathological and immunohistochemical study with genetic analysis of a case.
Carcinoma
Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy.
Carcinoma
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Carcinoma
Allelotype analysis of gallbladder carcinoma associated with anomalous junction of pancreaticobiliary duct.
Carcinoma
Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.
Carcinoma
Allelotype of human thyroid tumors: loss of chromosome 11q13 sequences in follicular neoplasms.
Carcinoma
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Carcinoma
Alterations of p16/CDKN2, p53 and ras genes in oral squamous cell carcinomas and premalignant lesions.
Carcinoma
Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use.
Carcinoma
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Carcinoma
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
Carcinoma
Amplified expression of p21 ras protein in hormone-dependent mammary carcinomas of humans and rodents.
Carcinoma
An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer.
Carcinoma
An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.
Carcinoma
An effect of K-ras gene mutation on epidermal growth factor receptor signal transduction in PANC-1 pancreatic carcinoma cells.
Carcinoma
An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.
Carcinoma
Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.
Carcinoma
Analysis of K-ras codon 12 point mutations using duodenal lavage fluid for diagnosis of pancreatic carcinoma.
Carcinoma
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Carcinoma
Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.
Carcinoma
Analysis of K-ras oncogene mutation directly applied to atypical cell clusters on cytologic smear slides of bile and pancreatic juice.
Carcinoma
Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.
Carcinoma
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
Carcinoma
Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
Carcinoma
Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab.
Carcinoma
Analysis of the genetic alterations in a case of juvenile multiple colon carcinoma with hypogammaglobulinemia.
Carcinoma
Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
Carcinoma
Antisera to the variable region of ras oncogene proteins, and specific detection of H-ras expression in an experimental model of chemical carcinogenesis.
Carcinoma
APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
Carcinoma
Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
Carcinoma
Apoptosis of Human Pancreatic Carcinoma PC-2 Cells by an Antisense Oligonucleotide Specific to Point Mutated K-ras.
Carcinoma
Appendiceal mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma and K-RAS mutation.
Carcinoma
Application of pyrosequencing technique for improved detection of K-Ras mutation in formalin-fixed and paraffin-embedded prostate carcinoma tissues in Chinese patients.
Carcinoma
Application of the p53 and K-ras gene mutation patterns for cytologic diagnosis of recurrent lung carcinomas.
Carcinoma
Assay design and optimization of mutant-enriched PCR based method for detection of K-ras gene mutations in pancreatic carcinoma.
Carcinoma
Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.
Carcinoma
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Carcinoma
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma
Autoimmune pancreatitis and biliary intraepithelial neoplasia of the common bile duct: A case with diagnostically challenging but pathogenetically significant association.
Carcinoma
Beta 1-6 branching of N-linked carbohydrate is associated with K-ras mutation in human colon carcinoma cell lines.
Carcinoma
beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
Carcinoma
Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Carcinoma
Biodegradable Nanocapsules as siRNA Carriers for Mutant K-Ras Gene Silencing of Human Pancreatic Carcinoma Cells.
Carcinoma
Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
Carcinoma
Bmi-1 Cooperates with H-Ras to Transform Human Mammary Epithelial Cells via Dysregulation of Multiple Growth-Regulatory Pathways.
Carcinoma
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
Carcinoma
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets.
Carcinoma
Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease.
Carcinoma
Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype.
Carcinoma
c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
Carcinoma
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
Carcinoma
Can Different Thyroid Tumor Types Be Distinguished by Polymerase Chain Reaction-Based K-ras Mutation Detection?
Carcinoma
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
Carcinoma
Cannabinoid receptor type 1 (CB1) activation inhibits small GTPase RhoA activity and regulates motility of prostate carcinoma cells.
Carcinoma
Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma.
Carcinoma
Carcinogenesis of malignant lesions of the gall bladder. The impact of chronic inflammation and gallstones.
Carcinoma
Carcinogenic role of K-Ras-ERK1/2 signaling in bladder cancer via inhibition of H1.2 phosphorylation at T146.
Carcinoma
Carcinoma of the colon in childhood; report of 2 cases expressing p53 without K-ras mutation.
Carcinoma
CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck.
Carcinoma
CCR7 regulates cell migration and invasion through MAPKs in metastatic squamous cell carcinoma of head and neck.
Carcinoma
CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.
Carcinoma
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells.
Carcinoma
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis.
Carcinoma
CEA is the major PHA-L-reactive glycoprotein in colon carcinoma cell lines and tumors: relationship between K-ras activation and beta1-6 branching of N-linked carbohydrate on CEA.
Carcinoma
Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways.
Carcinoma
Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination.
Carcinoma
Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations.
Carcinoma
Characterization of adenocarcinoma of the lung in a familial adenomatous polyposis patient.
Carcinoma
Characterization of lectin resistant cell populations derived from human colon carcinoma: correlation of K-Ras with beta1-6 branching of N-linked carbohydrate and CEA production.
Carcinoma
Characterization of Rab27a and JFC1 as constituents of the secretory machinery of prostate-specific antigen in prostate carcinoma cells.
Carcinoma
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Carcinoma
Clinical application of K-ras oncogene mutations in pancreatic carcinoma: detection of micrometastases.
Carcinoma
Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.
Carcinoma
Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis.
Carcinoma
Clinicopathologic analysis of k-ras, p53, and ERBB-2 gene alterations in pulmonary adenocarcinoma.
Carcinoma
Clinicopathologic features and genetic alterations in endometrioid carcinoma of the uterus with villoglandular differentiation.
Carcinoma
Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
Carcinoma
Clinicopathological observations of colorectal serrated lesions associated with invasive carcinoma and high-grade intraepithelial neoplasm.
Carcinoma
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Carcinoma
Cloning and sequencing of CATR1.3, a human gene associated with tumorigenic conversion.
Carcinoma
Combination analysis of genetic alterations and cell proliferation in small intestinal carcinomas.
Carcinoma
Combined small-cell carcinoma of the stomach: p53 and K-ras gene mutational analysis supports a monoclonal origin of three histological components.
Carcinoma
Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours.
Carcinoma
Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individual.
Carcinoma
Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-hydroxypropyl)amine.
Carcinoma
Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women.
Carcinoma
Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth.
Carcinoma
Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
Carcinoma
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
Carcinoma
Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma.
Carcinoma
Correlation of genes associated with drug response to prognosis of large cell lung carcinoma.
Carcinoma
Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma.
Carcinoma
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
Carcinoma
Cyclin D1 and p21 in ulcerative colitis-related inflammation and epithelial neoplasia: a study of aberrant expression and underlying mechanisms.
Carcinoma
Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas.
Carcinoma
Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas.
Carcinoma
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis.
Carcinoma
Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.
Carcinoma
Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
Carcinoma
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Carcinoma
Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
Carcinoma
Detection and clinical correlations of ras gene mutations in human ovarian tumors.
Carcinoma
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Carcinoma
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Carcinoma
Detection of colorectal cancer K-ras mutations using a simplified oligonucleotide ligation assay.
Carcinoma
Detection of H-ras gene point mutations in transitional cell carcinoma of human urinary bladder using polymerase chain reaction.
Carcinoma
Detection of HPV and ras gene mutations in cervical smears from female genital lesions.
Carcinoma
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Carcinoma
Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer.
Carcinoma
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Carcinoma
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Carcinoma
Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
Carcinoma
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
Carcinoma
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Carcinoma
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Carcinoma
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Carcinoma
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Carcinoma
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Carcinoma
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Carcinoma
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Carcinoma
Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
Carcinoma
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Carcinoma
Detection of rare circulating human colon tumor cells in a nude mouse xenograft model.
Carcinoma
Detection of ras gene mutations in human lung cancer: comparison of two screening assays based on the polymerase chain reaction.
Carcinoma
Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.
Carcinoma
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation.
Carcinoma
Diagnosis of pancreatic lesions using fine needle aspiration cytology: detection of K-ras point mutations using solid phase minisequencing.
Carcinoma
Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma.
Carcinoma
Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
Carcinoma
Diagnostic value of combining CA 19-9 and K-ras gene mutation in pancreatic carcinoma: a meta-analysis.
Carcinoma
Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
Carcinoma
Different amounts of K-ras mutant epithelial cells in pancreatic carcinoma and mass-forming pancreatitis.
Carcinoma
Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.
Carcinoma
Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Carcinoma
Differential expression of c-myc and H-ras oncogenes in Barrett's epithelium. A study using colorimetric in situ hybridization.
Carcinoma
Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior.
Carcinoma
Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42.
Carcinoma
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Carcinoma
DNA content and other factors associated with ten-year survival after resection of pancreatic carcinoma.
Carcinoma
Does Harvey-Ras gene expression lead to oral squamous cell carcinoma? A clinicopathological aspect.
Carcinoma
Down-regulation of the Rho GTPase signaling pathway is involved in the microRNA-138 mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
Carcinoma
Downregulation of survivin and aurora a by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy.
Carcinoma
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Carcinoma
Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice.
Carcinoma
Effect of increased expression of both ras-related C3 botulinum toxin substrate 1 and p21-activated kinase 1 in patients with N0M0 upper urinary tract urothelial carcinoma and cancer-free surgical margins.
Carcinoma
Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo.
Carcinoma
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Carcinoma
EGFR and K-ras gene mutation status in squamous cell anal carcinoma: a role for concurrent radiation and EGFR inhibitors?
Carcinoma
Emerging prognostic markers related to mesenchymal characteristics of poorly differentiated breast cancers.
Carcinoma
EML4-ALK fusion transcripts, but no NPM-, TPM3-, CLTC-, ATIC-, or TFG-ALK fusion transcripts, in non-small cell lung carcinomas.
Carcinoma
Endometrial carcinomas with significant mucinous differentiation associated with higher frequency of k-ras mutations: a morphologic and molecular correlation study.
Carcinoma
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.
Carcinoma
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Carcinoma
Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis.
Carcinoma
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Carcinoma
Establishment and molecular profiling of a novel human pancreatic cancer panel for 5-FU.
Carcinoma
Estimation of risk based on multiple events in radiation carcinogenesis of rat skin.
Carcinoma
Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis.
Carcinoma
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma.
Carcinoma
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.
Carcinoma
Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation.
Carcinoma
Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture.
Carcinoma
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Carcinoma
Expression of Kirsten-ras p21 in gastric cancer correlates with tumor progression and is prognostic.
Carcinoma
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Carcinoma
Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon.
Carcinoma
Expression of Rac1, HIF-1?, and VEGF in Gastric Carcinoma: Correlation with Angiogenesis and Prognosis.
Carcinoma
Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.
Carcinoma
Expression of the farnesyltransferase beta-subunit gene in human ovarian carcinoma: correlation to K-ras mutation.
Carcinoma
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
Carcinoma
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Carcinoma
Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
Carcinoma
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Carcinoma
Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas.
Carcinoma
Frequent mutations of the p53 gene and infrequent H- and K-ras mutations in urinary bladder carcinomas of NON/Shi mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinoma
Frequent p53 and H-ras mutations in benzene- and ethylene oxide-induced mammary gland carcinomas from B6C3F1 mice.
Carcinoma
Frequent p53 mutation in brain (fetal)-type glycogen phosphorylase positive foci adjacent to human 'de novo' colorectal carcinomas.
Carcinoma
Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer.
Carcinoma
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Carcinoma
From pancreatic intraepithelial neoplasia to cancer: a dramatic progression with K-ras status analysis.
Carcinoma
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
Carcinoma
Gallbladder adenomas have molecular abnormalities different from those present in gallbladder carcinomas.
Carcinoma
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Carcinoma
Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors.
Carcinoma
Gene mutations of K-ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Carcinoma
Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas.
Carcinoma
Generation of stable CD4+ and CD8+ T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations.
Carcinoma
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
Carcinoma
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.
Carcinoma
Genetic alterations in ovarian carcinoma: with specific reference to histological subtypes.
Carcinoma
Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
Carcinoma
Genetic alterations in the 61st codon of the H-ras oncogene isolated from archival sections of hepatic hyperplasias, adenomas and carcinomas in control groups of B6C3F1 mouse bioassay studies conducted from 1979 to 1986.
Carcinoma
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Carcinoma
Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum.
Carcinoma
Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism.
Carcinoma
Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
Carcinoma
Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.
Carcinoma
Genetic changes of p53, K-ras, and microsatellite instability in gallbladder carcinoma in high-incidence areas of Japan and Hungary.
Carcinoma
Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinoma
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.
Carcinoma
Genetic pathways of 'de novo' colorectal carcinomas with reference to fetal-type glycogen phosphorylase positive foci.
Carcinoma
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Carcinoma
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
Carcinoma
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Carcinoma
Growth factor-dependent activation of the Ras-Raf-MEK-MAPK pathway in the human pancreatic carcinoma cell line PANC-1 carrying activated K-ras: implications for cell proliferation and cell migration.
Carcinoma
Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.
Carcinoma
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
Carcinoma
H-ras 61st codon activation in archival proliferative hepatic lesions isolated from female B6C3F1 mice exposed to the leukotriene D4-antagonist, LY171883.
Carcinoma
H-Ras activation and fibroblast-induced TGF-? signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma.
Carcinoma
H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
Carcinoma
H-ras and Nm23-H1 gene expression and proteolytic activity in squamous cell carcinoma of the uterine cervix.
Carcinoma
H-ras gene amplification or mutation is not common in human primary breast cancer.
Carcinoma
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma.
Carcinoma
H-Ras mutation modulates the expression of major cell cycle regulatory proteins and disease prognosis in oral carcinoma.
Carcinoma
H-ras mutations in rat urinary bladder carcinomas induced by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide and sodium saccharin, sodium ascorbate, or related salts.
Carcinoma
H-Ras oncogene counteracts the growth-inhibitory effect of genistein in T24 bladder carcinoma cells.
Carcinoma
H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer.
Carcinoma
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Carcinoma
H-ras-1 gene mutations in basal cell carcinoma: automated direct sequencing of clinical specimens.
Carcinoma
Hammerhead ribozyme specifically inhibits mutant K-ras mRNA of human pancreatic cancer cells.
Carcinoma
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
Carcinoma
Helicobacter pylori induces formation of stress fibers and membrane ruffles in AGS cells by rac activation.
Carcinoma
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Carcinoma
Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
Carcinoma
Heterogeneous immunoreactivity of frozen human benign and malignant breast lesions to C-MYC and C-Ha-ras cellular oncogenes.
Carcinoma
HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma.
Carcinoma
High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
Carcinoma
High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.
Carcinoma
High frequency of K-ras mutations in biliary duct carcinomas of cases with a long common channel in the papilla of Vater.
Carcinoma
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
Carcinoma
High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion.
Carcinoma
High incidence of point mutation in K-ras codon 12 in carcinoma of the fallopian tube.
Carcinoma
High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations.
Carcinoma
High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.
Carcinoma
High TUBB3 expression, an independent prognostic marker in patients with early non small cell lung cancer (NSCLC) treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.
Carcinoma
High-level microsatellite instability is not involved in gallbladder carcinogenesis.
Carcinoma
Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma.
Carcinoma
Histological and genetic changes in malignant transformation of gallbladder adenoma.
Carcinoma
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
Carcinoma
Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
Carcinoma
Hypermethylation of the Ras association domain family 1A (RASSF1A) gene in gallbladder cancer.
Carcinoma
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.
Carcinoma
Hypoxia up-regulates hypoxia-inducible factor-1alpha expression through RhoA activation in trophoblast cells.
Carcinoma
Identification of a human CD8+ T lymphocyte neo-epitope created by a ras codon 12 mutation which is restricted by the HLA-A2 allele.
Carcinoma
Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach.
Carcinoma
Identification of site-specific prognostic biomarkers in patients with oral squamous cell carcinoma.
Carcinoma
Immunobead-PCR: a technique for the detection of circulating tumor cells using immunomagnetic beads and the polymerase chain reaction.
Carcinoma
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Carcinoma
Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck.
Carcinoma
Immunohistochemical evaluation of K-ras, p53, and HER-2/neu expression in hyperplastic, dysplastic, and carcinomatous lesions of the pancreas: evidence for multistep carcinogenesis.
Carcinoma
Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice.
Carcinoma
In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells.
Carcinoma
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Carcinoma
Increased susceptibility of H-Ras(G12V)-transformed human urothelial cells to the genotoxic effects of sodium arsenite.
Carcinoma
Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
Carcinoma
Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
Carcinoma
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Carcinoma
Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility.
Carcinoma
Inhibitary effects of antisense oligonucleotide specific to K-ras point mutation on the target gene expression in human pancreatic carcinoma cells.
Carcinoma
Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells.
Carcinoma
Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.
Carcinoma
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Carcinoma
Inhibition of Fos- and Ras-induced transformation by mutant Fos proteins with structural alterations in functionally different domains.
Carcinoma
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
Carcinoma
Inhibition of tumor cell growth by monoterpenes in vitro: evidence of a Ras-independent mechanism of action.
Carcinoma
Inhibitory effect of sarcophytol A on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxypropyl)amine in Syrian hamsters.
Carcinoma
Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.
Carcinoma
Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development.
Carcinoma
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Carcinoma
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Carcinoma
Intranuclear androgen receptor deployment and protooncogene expression in human diseased prostate.
Carcinoma
Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation.
Carcinoma
Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma.
Carcinoma
Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
Carcinoma
Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma.
Carcinoma
K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
Carcinoma
K-ras activation and ras p21 expression in latent prostatic carcinoma in Japanese men.
Carcinoma
K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
Carcinoma
K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary.
Carcinoma
K-Ras and its inhibitors towards personalized cancer treatment: Pharmacological and structural perspectives.
Carcinoma
K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas.
Carcinoma
K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma.
Carcinoma
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
Carcinoma
K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
Carcinoma
K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.
Carcinoma
K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
Carcinoma
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
Carcinoma
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
Carcinoma
K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients.
Carcinoma
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
Carcinoma
K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report.
Carcinoma
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
Carcinoma
K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.
Carcinoma
K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.
Carcinoma
K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung.
Carcinoma
K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
Carcinoma
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
Carcinoma
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
Carcinoma
K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
Carcinoma
K-ras mutation and loss of heterozygosity at 17p with beta-catenin accumulation in intramucosal carcinoma of the ileostomy in familial adenomatous polyposis: a case report.
Carcinoma
K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
Carcinoma
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
Carcinoma
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
Carcinoma
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Carcinoma
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma.
Carcinoma
K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
Carcinoma
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
Carcinoma
K-ras mutations (codon 12) are not involved in down-regulation of MHC class-I genes in colon carcinomas.
Carcinoma
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Carcinoma
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
Carcinoma
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
Carcinoma
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
Carcinoma
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
Carcinoma
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
Carcinoma
K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma.
Carcinoma
K-ras mutations in gastric stump carcinomas and in carcinomas from the non-operated stomach.
Carcinoma
K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
Carcinoma
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
Carcinoma
K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
Carcinoma
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
Carcinoma
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Carcinoma
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
Carcinoma
K-ras point mutations are rare events in premalignant forms of Barrett's oesophagus.
Carcinoma
K-ras point mutations in routinely processed tissues: non-radioactive screening by single strand conformational polymorphism analysis.
Carcinoma
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
Carcinoma
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Carcinoma
K-ras status in squamous cell anal carcinoma (SCC): it's time for target-oriented treatment?
Carcinoma
KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants.
Carcinoma
Lack of constitutive activation of MAP kinase pathway in human acute myeloid leukemia cells with N-Ras mutation.
Carcinoma
Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
Carcinoma
Lack of ras mutations and prediction of long-term survival in carcinoma of the colon.
Carcinoma
Late occurrence of K-ras gene mutations in the pathogenesis of squamous cell carcinoma of the lung: analysis in sputum.
Carcinoma
Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.
Carcinoma
Local cytokine treatment of HPV16-associated tumours results in inhibition of their lung metastases.
Carcinoma
Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
Carcinoma
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Carcinoma
Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells.
Carcinoma
Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice.
Carcinoma
Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black.
Carcinoma
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Carcinoma
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Carcinoma
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Carcinoma
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
Carcinoma
Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract.
Carcinoma
Low levels of ras p21 oncogene expression correlates with clinical outcome in head and neck squamous cell carcinoma.
Carcinoma
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Carcinoma
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
Carcinoma
Maintenance of growth factor signaling through Ras in human colon carcinoma cells containing K-ras mutations.
Carcinoma
Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.
Carcinoma
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Carcinoma
Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent.
Carcinoma
Metachronous colorectal and biliary carcinoma: the aetiological implications of k-ras oncogenes.
Carcinoma
Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.
Carcinoma
microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.
Carcinoma
MicroRNA-429 inhibits the proliferation and migration of esophageal squamous cell carcinoma cells by targeting RAB23 through the NF-?B pathway.
Carcinoma
Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
Carcinoma
miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42.
Carcinoma
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
Carcinoma
MiR-181d functions as a potential tumor suppressor in oral squamous cell carcinoma by targeting K-ras.
Carcinoma
miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27A.
Carcinoma
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
Carcinoma
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma [Retraction].
Carcinoma
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma.
Carcinoma
miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.
Carcinoma
miR-384 suppressed renal cell carcinoma cell proliferation and migration through targeting RAB23.
Carcinoma
miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.
Carcinoma
Modulation of mdr-1 expression by a H-ras oncogene in a human colon carcinoma cell line.
Carcinoma
Molecular alterations in oral carcinogenesis: significant risk predictors in malignant transformation and tumor progression.
Carcinoma
Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervix.
Carcinoma
Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
Carcinoma
Molecular cloning of rat Krev-1 cDNA and analysis of the mRNA levels in normal and NMU-induced mammary carcinomas.
Carcinoma
Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome.
Carcinoma
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
Carcinoma
Molecular genetic changes in epithelial, stromal and mixed neoplasms of the endometrium.
Carcinoma
Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.
Carcinoma
Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.
Carcinoma
Molecular Pathology of Endometrial Carcinoma: Practical aspects from the diagnostic and therapeutical view points.
Carcinoma
Molecular pathology of endometrial carcinoma: transcriptional signature in endometrioid tumors.
Carcinoma
Molecular profile of grade 3 endometrioid endometrial carcinoma: is it a type I or type II endometrial carcinoma?
Carcinoma
Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy.
Carcinoma
Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis.
Carcinoma
MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
Carcinoma
Mucinous and nonmucinous appendiceal adenocarcinomas: different clinicopathological features but similar genetic alterations.
Carcinoma
Mucinous carcinomas of the colorectum have distinct molecular genetic characteristics.
Carcinoma
Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
Carcinoma
Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma.
Carcinoma
Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas.
Carcinoma
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Carcinoma
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Carcinoma
Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
Carcinoma
Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
Carcinoma
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Carcinoma
Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.
Carcinoma
Mutation analysis of K-ras and beta-catenin genes related to O6-methylguanin-DNA methyltransferase and mismatch repair protein status in human gallbladder carcinoma.
Carcinoma
Mutation of K-RAS protooncogene and loss of heterozygosity on 6q27 in serous and mucinous ovarian carcinomas.
Carcinoma
Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.
Carcinoma
Mutation of K-ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors.
Carcinoma
Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.
Carcinoma
Mutation Spectra of Kras and Tp53 in Urethral and Lung Neoplasms in B6C3F1 Mice Treated with 3,3',4,4'-Tetrachloroazobenzene.
Carcinoma
Mutational activation of c-Ha-ras genes in intraductal proliferation induced by N-nitroso-N-methylurea in rat mammary glands.
Carcinoma
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Carcinoma
Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability.
Carcinoma
Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
Carcinoma
Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: invasive MPSC (low-grade tumor) and conventional serous carcinoma (high-grade tumor).
Carcinoma
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
Carcinoma
Mutational status of codons 12 and 13 of the N- and K-ras genes in tissue and cell lines derived from primary and metastatic prostate carcinomas.
Carcinoma
Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis.
Carcinoma
Mutations in the K-ras oncogene induced by 1,2-dimethylhydrazine in preneoplastic and neoplastic rat colonic mucosa.
Carcinoma
Mutations of K-ras but not p53 genes in biliary duct and pancreatic duct carcinomas induced in hamsters by cholecystoduodenostomy with dissection of the common duct followed by N-nitrosobis(2-oxopropyl)amine.
Carcinoma
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Carcinoma
Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy.
Carcinoma
Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
Carcinoma
Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.
Carcinoma
Neoplastic transformation of human keratinocytes by polybrene-induced DNA-mediated transfer of an activated oncogene.
Carcinoma
Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells.
Carcinoma
Neurotensin and EGF induce synergistic stimulation of DNA synthesis by increasing the duration of ERK signaling in ductal pancreatic cancer cells.
Carcinoma
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
Carcinoma
NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells.
Carcinoma
NIH3T3 transfectant containing human K-ras oncogene shows enhanced metastatic activity after in vivo tumor growth or co-culture with fibroblasts.
Carcinoma
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Carcinoma
Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction with microsatellite instability, K-ras wild type.
Carcinoma
Non-involvement of the K-ras mutation in colon carcinogenesis promoted by dietary deoxycholate in azoxymethane-treated rats.
Carcinoma
Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization.
Carcinoma
Nonfunctioning islet cell carcinoma of the pancreas with high serum CEA & CA19-9, K-ras codon 12 mutation, and microsatellite instability.
Carcinoma
NTP toxicology and carcinogensis studies of vanadium pentoxide (CAS No. 1314-62-1) in F344/N rats and B6C3F1 mice (inhalation).
Carcinoma
Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: An important autocrine/paracrine factor in tumor progression.
Carcinoma
Nucleolar localization of Small G protein RhoA is associated with active RNA synthesis in human carcinoma HEp-2 cells.
Carcinoma
o-Nitrotoluene-induced large intestinal tumors in B6C3F1 mice model human colon cancer in their molecular pathogenesis.
Carcinoma
O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.
Carcinoma
Oncogene activation in experimental carcinogenesis: the role of carcinogen and tissue specificity.
Carcinoma
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
Carcinoma
Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.
Carcinoma
Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Carcinoma
Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
Carcinoma
Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells.
Carcinoma
Oncogenic Ras modulates epidermal growth factor responsiveness in endometrial carcinomas.
Carcinoma
Osteoclast-like giant cell tumor of the pancreas with metastases to gallbladder and lymph nodes. A case report.
Carcinoma
Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.
Carcinoma
Ovarian small cell carcinoma with K-ras mutation: a case report with genetic analysis.
Carcinoma
Overexpression of p53 protein and point mutation of K-ras genes in primary carcinoma of the small intestine.
Carcinoma
Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma.
Carcinoma
Overexpression of RIN1 associates with tumor grade and progression in patients of bladder urothelial carcinoma.
Carcinoma
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Carcinoma
Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.
Carcinoma
Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
Carcinoma
Overlapping functions of Ras and Rac GTPases in regulating cancer cell proliferation and invasion.
Carcinoma
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
Carcinoma
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
Carcinoma
p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
Carcinoma
P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.
Carcinoma
p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Carcinoma
p53 and p21/Waf1 protein expression and K-ras codon 12 mutation in carcinoma of the papilla of Vater.
Carcinoma
p53 and ras gene mutations in lung cancer: implications for smoking and occupational exposures.
Carcinoma
p53 mutations in early neoplastic lesions of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinoma
p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Carcinoma
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
Carcinoma
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors.
Carcinoma
Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene.
Carcinoma
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
Carcinoma
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Carcinoma
Pancreatic lymph nodal and plexus micrometastases detected by enriched polymerase chain reaction and nonradioisotopic single-strand conformation polymorphism analysis: a new predictive factor for recurrent pancreatic carcinoma.
Carcinoma
Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.
Carcinoma
Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1.
Carcinoma
Pathology and proliferative activity of renal-cell carcinomas (RCCS) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine.
Carcinoma
Phase I first-in-human study of HLX07, a novel and improved recombinant anti-EGFR humanized monoclonal antibody, in patients with advanced solid cancers.
Carcinoma
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Carcinoma
Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras.
Carcinoma
Prerequisites for effective adenovirus mediated gene therapy of colorectal liver metastases in the rat using an intracellular neutralizing antibody fragment to p21-Ras.
Carcinoma
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Carcinoma
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.
Carcinoma
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Carcinoma
Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
Carcinoma
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Carcinoma
Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes.
Carcinoma
Prevalence of K-RAS mutations and CA125 tumor marker in patients with ovarian carcinoma.
Carcinoma
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
Carcinoma
Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.
Carcinoma
Production of spindle cell carcinoma by transduction of H-Ras 61L into immortalized human mammary epithelial cells.
Carcinoma
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Carcinoma
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Carcinoma
Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
Carcinoma
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Carcinoma
Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
Carcinoma
Prognostic significance of molecular markers in oral squamous cell carcinoma: A multivariate analysis.
Carcinoma
Prognostic value of CpG island hypermethylation at PTGS2, RAR-beta, EDNRB, and other gene loci in patients undergoing radical prostatectomy.
Carcinoma
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Carcinoma
Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.
Carcinoma
Proliferative heterogeneity of human renal cell carcinomas and prevalence of ras gene point mutations.
Carcinoma
Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union.
Carcinoma
Proteome of Metastatic Canine Mammary Carcinomas: Similarities to and Differences from Human Breast Cancer ().
Carcinoma
pS2 expression as a possible diagnostic marker of colorectal carcinoma in ulcerative colitis.
Carcinoma
PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.
Carcinoma
Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis.
Carcinoma
Quantitating the frequency of initiation and cH-ras mutation in in situ N-methyl-N-nitrosourea-exposed rat mammary gland.
Carcinoma
Quantity of mutant K-ras gene in pancreatic secretions for diagnosis of pancreatic carcinoma with different assays: analysis of 100 patients.
Carcinoma
Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-?B) Signaling Pathway in Human Bladder Carcinoma.
Carcinoma
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Carcinoma
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Carcinoma
Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin ?1/Rac1 pathway.
Carcinoma
RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
Carcinoma
Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression.
Carcinoma
Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells.
Carcinoma
Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation.
Carcinoma
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Carcinoma
Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression.
Carcinoma
RalA regulates vascular endothelial growth factor-C (VEGF-C) synthesis in prostate cancer cells during androgen ablation.
Carcinoma
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Carcinoma
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
Carcinoma
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma
Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.
Carcinoma
Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.
Carcinoma
Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter.
Carcinoma
Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea.
Carcinoma
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
Carcinoma
ras gene activation and infrequent mutation in papillary serous carcinoma of the peritoneum.
Carcinoma
ras gene alterations in invasive and non-invasive rat bladder carcinomas induced by N-methyl-N-nitrosourea.
Carcinoma
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Carcinoma
Ras gene point mutations in gallbladder lesions associated with anomalous connection of pancreatobiliary ducts.
Carcinoma
Ras involvement in cells transformed with 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) in vitro and with N-[4-(5-nitro-2-furyl)-2-thiazoyl]formamide in vivo.
Carcinoma
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Carcinoma
RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects.
Carcinoma
RAS Mutations Are the Predominant Molecular Alteration in Poorly Differentiated Thyroid Carcinomas and Bear Prognostic Impact.
Carcinoma
Ras oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids.
Carcinoma
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Carcinoma
Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas.
Carcinoma
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Carcinoma
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Carcinoma
Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.
Carcinoma
Remission of acromegaly caused by pituitary carcinoma after surgical excision of growth hormone-secreting metastasis detected by 111-indium pentetreotide scan.
Carcinoma
Results of a Phase I Trial of 12 Patients With Locally Advanced Pancreatic Carcinoma Combining Gefitinib, Paclitaxel, and 3-Dimensional Conformal Radiation: Report of Toxicity and Evaluation of Circulating K-ras as a Potential Biomarker of Response to Therapy.
Carcinoma
Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.
Carcinoma
RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells.
Carcinoma
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Carcinoma
Role of ARHGAP24 in ADP Ribosylation Factor 6 (ARF6)-dependent Pseudopod Formation in Human Breast Carcinoma Cells.
Carcinoma
Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
Carcinoma
S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Carcinoma
Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors.
Carcinoma
Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan.
Carcinoma
Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.
Carcinoma
Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Carcinoma
Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer.
Carcinoma
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Carcinoma
Similar incidence of K-ras mutations in lung carcinomas of FVB/N mice and FVB/N mice carrying a mutant p53 transgene.
Carcinoma
Single-Pattern Convergence of K-ras Mutation Correlates With Surgical Indication of Intraductal Papillary Mucinous Neoplasms.
Carcinoma
Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases.
Carcinoma
Small interfering RNAs targeting mutant K-ras inhibit human pancreatic carcinoma cells growth in vitro and in vivo.
Carcinoma
SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma.
Carcinoma
Smoking, oncogenes and human lung cancer. A review of recent laboratory evidence linking smoking and lung cancer.
Carcinoma
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Carcinoma
Somatic APC and K-ras codon 12 mutations in periampullary adenomas and carcinomas from familial adenomatous polyposis patients.
Carcinoma
Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.
Carcinoma
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.
Carcinoma
Splicing variant of Cdc42 interacting protein-4 disrupts beta-catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma.
Carcinoma
Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation.
Carcinoma
Supplemental dietary calcium fails to alter the acute effects of 1,2-dimethylhydrazine on O6-methylguanine, O6-alkylguanine-DNA alkyltransferase and cellular proliferation in the rat colon.
Carcinoma
Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
Carcinoma
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Carcinoma
Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
Carcinoma
Synergistic effect of MNU and DMBA in mammary carcinogenesis and H-ras activation in female Sprague-Dawley rats.
Carcinoma
The Adaptor Protein and Arf GTPase-activating Protein Cat-1/Git-1 Is Required for Cellular Transformation.
Carcinoma
The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma.
Carcinoma
The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma.
Carcinoma
The association of the H-ras oncogene and steroid hormone receptors in gynecological cancer.
Carcinoma
The balanced induction of K-ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues.
Carcinoma
The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status.
Carcinoma
The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways.
Carcinoma
The grab-and-drop protocol: a novel strategy for membrane protein isolation and reconstitution from single cells.
Carcinoma
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
Carcinoma
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice.
Carcinoma
The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region.
Carcinoma
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
Carcinoma
The radiosensitivity of human keratinocytes: influence of activated c-H-ras oncogene expression and tumorigenicity.
Carcinoma
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Carcinoma
The Rho GTPase RhoE exerts tumor-suppressing effects in human esophageal squamous cell carcinoma via negatively regulating epidermal growth factor receptor.
Carcinoma
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
Carcinoma
The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.
Carcinoma
The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies.
Carcinoma
Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer.
Carcinoma
Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho.
Carcinoma
Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9).
Carcinoma
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Carcinoma
TP53 and p16INK4A, but not H-KI-Ras, are involved in tumorigenesis and progression of pleomorphic adenomas.
Carcinoma
Transforming growth factor beta1, ras and p53 in silica-induced fibrogenesis and carcinogenesis.
Carcinoma
Trimodality treatment in Stage III nonsmall cell lung carcinoma: prrognostic impact of K-ras mutations after neoadjuvant therapy.
Carcinoma
TSAP6 is a novel candidate marker of poor survival in metastatic high-grade serous carcinoma.
Carcinoma
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.
Carcinoma
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Carcinoma
Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies.
Carcinoma
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Carcinoma
Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer.
Carcinoma
Use of spontaneous Epstein-Barr virus-lymphoblastoid cell lines genetically modified to express tumor antigen as cancer vaccines: mutated p21 ras oncogene in pancreatic carcinoma as a model.
Carcinoma
Usefulness of supernatant of pancreatic juice for genetic analysis of K-ras in diagnosis of pancreatic carcinoma.
Carcinoma
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Carcinoma
Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer.
Carcinoma
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
Carcinoma
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Carcinoma
Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA.
Carcinoma
[Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene].
Carcinoma
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
Carcinoma
[Anatomopathological tools for screening and medical surveillance of people exposed to asbestos]
Carcinoma
[Cell kinetics of colorectal tumors with assessment by K-ras mutation and PCNA labeling index]
Carcinoma
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
Carcinoma
[Combined detection of K-ras mutation and CA19-9 level in plasma of patients with pancreatic cancer]
Carcinoma
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
Carcinoma
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
Carcinoma
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Carcinoma
[Detection of mutations of the K-ras gene in condensed breath of patients with non-small-cell lung carcinoma (NSCLC) as a possible noninvasive screening method]
Carcinoma
[Detection of point mutation of K-ras gene codon 12 in biliary tract and ampullary carcinoma by modified two-step polymerase chain reaction]
Carcinoma
[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
Carcinoma
[Effect of PCBs on mouse lung tumorigenesis induced by 1-nitropyrene: a preliminary report]
Carcinoma
[Effect of shRNA-mediated silence of H-ras gene on proliferation of human SACC-M cells]
Carcinoma
[General rules for the study of pancreatic cancer by molecular biological aspect]
Carcinoma
[Genetic alterations and transformations in development and establishment of uterine endometrial carcinomas]
Carcinoma
[Microdissection and PCR-SSCP detected mutation and expression of p53 and K-ras gene in carcinogenesis and development of induced rat lung carcinoma]
Carcinoma
[Molecular, genetic and immunohistochemical investigation of carcinosarcoma of the female reproductive tract]
Carcinoma
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
Carcinoma
[Mutation of the K-ras oncogene in pancreatic carcinoma, and application of its detection in pancreatic juice to diagnose pancreatic carcinoma]
Carcinoma
[Outcomes of patients with small bowel carcinoma treated with appropriate chemotherapy selected on the basis of genetic analysis findings].
Carcinoma
[Sensitive detection of K-ras oncogene codon 12 mutations by nested PCR using mismatched primers and selective digestion of non-mutated PCR fragments with restriction enzyme]
Carcinoma
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
Carcinoma
[Significance of detection of K-ras gene mutations and CA19-9 in serum for diagnosis of pancreatic carcinoma]
Carcinoma
[The diagnostic value of serum carcinoma markers, fecal K-ras and p53 gene mutation in pancreatic cancers]
Carcinoma
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
Carcinoma
[The study of the effect of antisense oligonucleotide specific to K-ras point mutation on human pancreatic carcinoma cell PC-2]
Carcinoma in Situ
Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
Carcinoma in Situ
Clinicopathological observations of colorectal serrated lesions associated with invasive carcinoma and high-grade intraepithelial neoplasm.
Carcinoma in Situ
Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior.
Carcinoma in Situ
H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer.
Carcinoma in Situ
Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
Carcinoma in Situ
Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion.
Carcinoma in Situ
Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer.
Carcinoma in Situ
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Carcinoma in Situ
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
Carcinoma, Acinar Cell
Multiple loss of heterozygosity without K-ras mutation identified by molecular analysis on fine-needle aspiration cytology specimen of acinar cell carcinoma of pancreas.
Carcinoma, Adenoid Cystic
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
Carcinoma, Adenoid Cystic
[Effect of shRNA-mediated silence of H-ras gene on proliferation of human SACC-M cells]
Carcinoma, Adenosquamous
Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases.
Carcinoma, Adenosquamous
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Carcinoma, Adenosquamous
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Carcinoma, Adenosquamous
Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung.
Carcinoma, Adenosquamous
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Carcinoma, Adenosquamous
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Carcinoma, Adenosquamous
Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.
Carcinoma, Adenosquamous
Trisomy 12 correlates with elevated expression of p21 ras in a human adenosquamous carcinoma of the lung.
Carcinoma, Basal Cell
H-ras-1 gene mutations in basal cell carcinoma: automated direct sequencing of clinical specimens.
Carcinoma, Bronchogenic
Lack of correlation between codon 12 K-ras mutations and major histocompatibility complex antigens in bronchogenic carcinomas.
Carcinoma, Ductal
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
Carcinoma, Ductal
Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients.
Carcinoma, Ductal
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Carcinoma, Ductal
High Frequency of Codon 12 but not Codon 13 and 61 K-ras Gene Mutations in Invasive Ductal Carcinoma of Breast in a South Indian Population.
Carcinoma, Ductal
Loss of a c-H-ras-1 allele and aggressive human primary breast carcinomas.
Carcinoma, Ductal
Origin of giant cells in osteoclast-like giant cell tumors of the pancreas.
Carcinoma, Ductal
Pancreatic lymph nodal and plexus micrometastases detected by enriched polymerase chain reaction and nonradioisotopic single-strand conformation polymorphism analysis: a new predictive factor for recurrent pancreatic carcinoma.
Carcinoma, Ductal
The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium.
Carcinoma, Ductal
[Differential genetic pathway of duct and acinar carcinomas of the pancreas]
Carcinoma, Embryonal
A transfected H-ras oncogene does not inhibit differentiation of cardiac and skeletal muscle from embryonal carcinoma cells.
Carcinoma, Embryonal
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation.
Carcinoma, Embryonal
Cdo promotes neuronal differentiation via activation of the p38 mitogen-activated protein kinase pathway.
Carcinoma, Embryonal
RhoB expression is induced after the transient upregulation of RhoA and Cdc42 during neuronal differentiation and influenced by culture substratum and microtubule integrity.
Carcinoma, Endometrioid
A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses.
Carcinoma, Endometrioid
Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability.
Carcinoma, Endometrioid
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Carcinoma, Endometrioid
Molecular Pathology of Endometrial Carcinoma: Practical aspects from the diagnostic and therapeutical view points.
Carcinoma, Endometrioid
Molecular profile of grade 3 endometrioid endometrial carcinoma: is it a type I or type II endometrial carcinoma?
Carcinoma, Endometrioid
Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
Carcinoma, Endometrioid
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.
Carcinoma, Endometrioid
[Dualistic model of molecular pathogenesis in endometrial carcinoma]
Carcinoma, Hepatocellular
A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells.
Carcinoma, Hepatocellular
A role for the small GTPase Rab21 in the early endocytic pathway.
Carcinoma, Hepatocellular
Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3 F1 mouse.
Carcinoma, Hepatocellular
Activation of H-ras oncogenes in male B6C3F1 mouse liver tumors induced by vinthionine or 2-chloroethyl-methyl sulfide.
Carcinoma, Hepatocellular
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Carcinoma, Hepatocellular
Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection.
Carcinoma, Hepatocellular
Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA--in vitro and in vivo studies.
Carcinoma, Hepatocellular
Aspafilioside B induces G2/M cell cycle arrest and apoptosis by up-regulating H-Ras and N-Ras via ERK and p38 MAPK signaling pathways in human hepatoma HepG2 cells.
Carcinoma, Hepatocellular
beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
Carcinoma, Hepatocellular
Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice.
Carcinoma, Hepatocellular
BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy.
Carcinoma, Hepatocellular
Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.
Carcinoma, Hepatocellular
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
Carcinoma, Hepatocellular
Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p.
Carcinoma, Hepatocellular
Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice.
Carcinoma, Hepatocellular
Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras.
Carcinoma, Hepatocellular
Depletion of Pokemon gene inhibits hepatocellular carcinoma cell growth through inhibition of H-ras.
Carcinoma, Hepatocellular
Detection of hepatitis-B virus-DNA and mutations in k-ras and p53 genes in human hepatocellular carcinomas.
Carcinoma, Hepatocellular
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Carcinoma, Hepatocellular
Differential expression of Rab27A/B correlates with clinical outcome in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation.
Carcinoma, Hepatocellular
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Carcinoma, Hepatocellular
Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
Carcinoma, Hepatocellular
Erratum: miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42.
Carcinoma, Hepatocellular
Expression of H-ras and c-myc protooncogenes in isolated gamma-glutamyl transpeptidase-positive rat hepatocytes and in hepatocellular carcinomas induced by diethylnitrosamine.
Carcinoma, Hepatocellular
Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
Carcinoma, Hepatocellular
Expression of Organic Anion Transporting Polypeptides in an H-Ras 12V Transgenic Mouse Model of Spontaneous Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.
Carcinoma, Hepatocellular
Gd-EOB-DTPA Enhanced Micro-MR Imaging of Hepatic Tumors in H-ras 12V Transgenic Mice.
Carcinoma, Hepatocellular
H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises.
Carcinoma, Hepatocellular
Hepatitis B virus X protein up-regulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.
Carcinoma, Hepatocellular
Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutations.
Carcinoma, Hepatocellular
Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP).
Carcinoma, Hepatocellular
High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma.
Carcinoma, Hepatocellular
Immunocytochemical localization of p21 ras gene product in human hepatoma cell lines and corresponding tumors in athymic mice.
Carcinoma, Hepatocellular
Increased expression of c-jun gene during spontaneous hepatocarcinogenesis in LEC rats.
Carcinoma, Hepatocellular
Infrequent point mutations in codons 12 and 61 of ras oncogenes in human hepatocellular carcinomas.
Carcinoma, Hepatocellular
Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42.
Carcinoma, Hepatocellular
Integrin ?9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling.
Carcinoma, Hepatocellular
Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency.
Carcinoma, Hepatocellular
K-ras Gene Mutations in Liver Carcinomas from a Mediterranean Area of Spain.
Carcinoma, Hepatocellular
Knockdown of mutated H-Ras V12 expression induces chemosensitivity of hepatocellular carcinoma cells to cisplatin treatment in vitro and in nude mouse xenografts.
Carcinoma, Hepatocellular
Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
Carcinoma, Hepatocellular
MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42.
Carcinoma, Hepatocellular
miR-145-5p Acts as a Novel Tumor Suppressor in Hepatocellular Carcinoma Through Targeting RAB18.
Carcinoma, Hepatocellular
miR-185 inhibits cell migration and invasion of hepatocellular carcinoma through CDC42.
Carcinoma, Hepatocellular
miR-455 Inhibits the Viability and Invasion by Targeting RAB18 in Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20.
Carcinoma, Hepatocellular
Molecular Characteristics of Fibrolamellar Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.
Carcinoma, Hepatocellular
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
Carcinoma, Hepatocellular
O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Oncogene mediated repression of glucocorticoid hormone response elements and glucocorticoid receptor levels.
Carcinoma, Hepatocellular
Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
Carcinoma, Hepatocellular
Preferential loss of heterozygosity of chromosome 7 loci in simian virus 40 t/T antigen-induced mouse hepatocellular carcinomas does not involve H-ras mutations.
Carcinoma, Hepatocellular
Prevalence of K-Ras mutations in hepatocellular carcinoma: A Turkish Oncology Group pilot study.
Carcinoma, Hepatocellular
RAB18 promotes proliferation and metastasis in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Rab23 is a potential biological target for treating hepatocellular carcinoma.
Carcinoma, Hepatocellular
Rab23 Promotes Hepatocellular Carcinoma Cell Migration Via Rac1/TGF-? Signaling.
Carcinoma, Hepatocellular
Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
Carcinoma, Hepatocellular
Rab5a promotes the migration and invasion of hepatocellular carcinoma by up-regulating Cdc42.
Carcinoma, Hepatocellular
Rap1b enhances the invasion and migration of hepatocellular carcinoma cells by up-regulating Twist 1.
Carcinoma, Hepatocellular
RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.
Carcinoma, Hepatocellular
Study of the correlation between H-ras mutation and primary hepatocellular carcinoma.
Carcinoma, Hepatocellular
Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines.
Carcinoma, Hepatocellular
Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect.
Carcinoma, Hepatocellular
The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2.
Carcinoma, Hepatocellular
The Rho GTPase Rnd1 inhibits epithelial-mesenchymal transition in hepatocellular carcinoma and is a favorable anti-metastasis target.
Carcinoma, Hepatocellular
Up-regulation of Rac GTPase activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Carcinoma, Hepatocellular
Vps34 Inhibits Hepatocellular Carcinoma Invasion by Regulating Endosome-Lysosome Trafficking via Rab7-RILP and Rab11.
Carcinoma, Hepatocellular
[A study on expression of various oncogenes and tumor-associated genes in LEC rats spontaneously developing hepatitis and hepatoma]
Carcinoma, Hepatocellular
[Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection]
Carcinoma, Hepatocellular
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
Carcinoma, Hepatocellular
[Influence of compensatory hepatocyte proliferation on the carcinogenesis of N-nitrosodimethylamine]
Carcinoma, Hepatocellular
[Relationships between intrahepatic metastasis of hepatocellular carcinoma and in situ microenvironment, and the abundance of nm23-H1 H-ras mRNA]
Carcinoma, Hepatocellular
[The effect of antisense H-ras on growth and metastasis of a high metastatic tumor model of human hepatoma in nude mice LCI-D20]
Carcinoma, Intraductal, Noninfiltrating
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
Carcinoma, Intraductal, Noninfiltrating
Different amounts of K-ras mutant epithelial cells in pancreatic carcinoma and mass-forming pancreatitis.
Carcinoma, Intraductal, Noninfiltrating
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Carcinoma, Intraductal, Noninfiltrating
K-ras gene mutation in early ductal lesions induced in a rapid production model for pancreatic carcinomas in Syrian hamsters.
Carcinoma, Intraductal, Noninfiltrating
Molecular characterization of intraductal breast carcinomas.
Carcinoma, Islet Cell
Nonfunctioning islet cell carcinoma of the pancreas with high serum CEA & CA19-9, K-ras codon 12 mutation, and microsatellite instability.
Carcinoma, Large Cell
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
Carcinoma, Large Cell
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Carcinoma, Large Cell
Validation of the Point-EXACCT method in non-small cell lung carcinomas.
Carcinoma, Lewis Lung
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Carcinoma, Mucoepidermoid
H-ras gene mutations in salivary gland mucoepidermoid carcinomas.
Carcinoma, Mucoepidermoid
Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis.
Carcinoma, Neuroendocrine
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Carcinoma, Neuroendocrine
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Carcinoma, Non-Small-Cell Lung
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer.
Carcinoma, Non-Small-Cell Lung
Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice.
Carcinoma, Non-Small-Cell Lung
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Carcinoma, Non-Small-Cell Lung
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Carcinoma, Non-Small-Cell Lung
An overview of farnesyltransferase inhibitors and their role in lung cancer therapy.
Carcinoma, Non-Small-Cell Lung
Analysis of K-ras, p53, bcl-2 and Rb expression in non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
Assessment of EGFR and K-ras mutations in fixed and fresh specimens from transesophageal ultrasound-guided fine needle aspiration in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes.
Carcinoma, Non-Small-Cell Lung
Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
Carcinoma, Non-Small-Cell Lung
Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.
Carcinoma, Non-Small-Cell Lung
c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status.
Carcinoma, Non-Small-Cell Lung
Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Combination therapy targeting BCL6 and phospho-STAT3 defeats intra-tumor heterogeneity in a subset of non-small cell lung cancers.
Carcinoma, Non-Small-Cell Lung
Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase.
Carcinoma, Non-Small-Cell Lung
Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
Carcinoma, Non-Small-Cell Lung
CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
Deletion of cyclooxygenase-2 inhibits K-ras-induced lung carcinogenesis.
Carcinoma, Non-Small-Cell Lung
DEPENDENCE ON THE MUC1-C ONCOPROTEIN IN NON-SMALL CELL LUNG CANCER CELLS WITH EGFR AND K-RAS MUTATIONS.
Carcinoma, Non-Small-Cell Lung
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.
Carcinoma, Non-Small-Cell Lung
Detection by denaturant gradient gel electrophoresis of tumor-specific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Carcinoma, Non-Small-Cell Lung
Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers.
Carcinoma, Non-Small-Cell Lung
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Carcinoma, Non-Small-Cell Lung
Downregulation of miR-25 modulates non-small cell lung cancer cells by targeting CDC42.
Carcinoma, Non-Small-Cell Lung
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Dr. Neri et al.: Prognostic role of K-ras mutations in non-small cell lung cancer: Still an issue for open debate.
Carcinoma, Non-Small-Cell Lung
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Carcinoma, Non-Small-Cell Lung
Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Effects of silencing Rab27a gene on biological characteristics and chemosensitivity of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model: evaluation by multimodality imaging.
Carcinoma, Non-Small-Cell Lung
EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens.
Carcinoma, Non-Small-Cell Lung
EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non-small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy.
Carcinoma, Non-Small-Cell Lung
EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
Carcinoma, Non-Small-Cell Lung
Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Epidermal Growth Factor Receptor Signaling in Nonsmall Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Carcinoma, Non-Small-Cell Lung
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Carcinoma, Non-Small-Cell Lung
Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients-An external validation.
Carcinoma, Non-Small-Cell Lung
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Carcinoma, Non-Small-Cell Lung
Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.
Carcinoma, Non-Small-Cell Lung
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
Carcinoma, Non-Small-Cell Lung
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Carcinoma, Non-Small-Cell Lung
Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Identification of a new inhibitor of KRAS-PDE? interaction targeting KRAS mutant non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
Carcinoma, Non-Small-Cell Lung
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
In vitro study of farnesyltransferase inhibitor SCH 66336, in combination with chemotherapy and radiation, in non-small cell lung cancer cell lines.
Carcinoma, Non-Small-Cell Lung
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Carcinoma, Non-Small-Cell Lung
Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.
Carcinoma, Non-Small-Cell Lung
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.
Carcinoma, Non-Small-Cell Lung
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.
Carcinoma, Non-Small-Cell Lung
Interferon-? reduces the gefitinib sensitivity of human non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
K-ras gene mutations in non-small cell lung cancer in Japanese.
Carcinoma, Non-Small-Cell Lung
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
k-RAS mutation and resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
k-RAS mutations in non-small cell lung cancer patients treated with TKIs among smokers and non-smokers: a meta-analysis.
Carcinoma, Non-Small-Cell Lung
K-ras oncogene mutation as a prognostic marker in non-small cell lung cancer: a combined analysis of 881 cases.
Carcinoma, Non-Small-Cell Lung
LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
Carcinoma, Non-Small-Cell Lung
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Carcinoma, Non-Small-Cell Lung
Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations.
Carcinoma, Non-Small-Cell Lung
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Carcinoma, Non-Small-Cell Lung
MicroRNA let-7a Inhibits the Proliferation and Invasion of Nonsmall Cell Lung Cancer Cell Line 95D by Regulating K-Ras and HMGA2 Gene Expression.
Carcinoma, Non-Small-Cell Lung
MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.
Carcinoma, Non-Small-Cell Lung
MiR-135a inhibits non-small cell lung cancer progression by suppressing RAB1B expression and the RAS pathway.
Carcinoma, Non-Small-Cell Lung
MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
Carcinoma, Non-Small-Cell Lung
Modification of mutant K-ras gene expression in non-small cell lung cancer (NSCLC).
Carcinoma, Non-Small-Cell Lung
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Carcinoma, Non-Small-Cell Lung
Molecular staging of non-small cell lung cancer according to K-ras genotypes.
Carcinoma, Non-Small-Cell Lung
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Carcinoma, Non-Small-Cell Lung
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Mutations in K-ras codon 12 detected in plasma DNA are not an indicator of disease in patients with non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Carcinoma, Non-Small-Cell Lung
Oncogenic Activity of Ect2 Is Regulated through Protein Kinase C{iota}-mediated Phosphorylation.
Carcinoma, Non-Small-Cell Lung
Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation.
Carcinoma, Non-Small-Cell Lung
Overexpression of small GTPases directly correlates with expression of ?-catenin and their coexpression predicts a poor clinical outcome in nonsmall cell lung cancer.
Carcinoma, Non-Small-Cell Lung
p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1.
Carcinoma, Non-Small-Cell Lung
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
Carcinoma, Non-Small-Cell Lung
PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Carcinoma, Non-Small-Cell Lung
Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis.
Carcinoma, Non-Small-Cell Lung
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Carcinoma, Non-Small-Cell Lung
Prognostic role of K-Ras mutations in non-small cell lung cancer: still an issue for open debate.
Carcinoma, Non-Small-Cell Lung
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Carcinoma, Non-Small-Cell Lung
Prognostic value of k-ras 12 genotypes in patients with advanced nonsmall cell lung-cancer receiving Carboplatin with either intravenous or chronic oral dose Etoposide.
Carcinoma, Non-Small-Cell Lung
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis.
Carcinoma, Non-Small-Cell Lung
Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
Carcinoma, Non-Small-Cell Lung
Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis.
Carcinoma, Non-Small-Cell Lung
RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
Carcinoma, Non-Small-Cell Lung
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Carcinoma, Non-Small-Cell Lung
Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Single-agent paclitaxel by 3-hour infusion in the treatment of non-small cell lung cancer: links between p53 and K-ras gene status and chemosensitivity.
Carcinoma, Non-Small-Cell Lung
SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma.
Carcinoma, Non-Small-Cell Lung
Sorafenib in patients with advanced non-small cell lung cancer that harbor K-ras mutations: a brief report.
Carcinoma, Non-Small-Cell Lung
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
Carcinoma, Non-Small-Cell Lung
TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-?B signalling.
Carcinoma, Non-Small-Cell Lung
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
Carcinoma, Non-Small-Cell Lung
The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
Carcinoma, Non-Small-Cell Lung
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies.
Carcinoma, Non-Small-Cell Lung
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Carcinoma, Non-Small-Cell Lung
Vascular endothelial growth factor and other biological predictors related to the postoperative survival rate on non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
[Correlation of expression of p120ctn , RhoA and Cdc42 and their significance in non-small cell lung cancer.]
Carcinoma, Non-Small-Cell Lung
[Detection of EGFR and K-ras mutations in non-small cell lung cancer using cytological specimens].
Carcinoma, Non-Small-Cell Lung
[Detection of mutations of the K-ras gene in condensed breath of patients with non-small-cell lung carcinoma (NSCLC) as a possible noninvasive screening method]
Carcinoma, Non-Small-Cell Lung
[Enhanced growth inhibition by combined two pathway inhibitors on K-ras mutated non-small cell lung cancer cells].
Carcinoma, Non-Small-Cell Lung
[Expression and clinical significance of caspase-3,survivin and k-ras in non-small cell lung cancer.]
Carcinoma, Non-Small-Cell Lung
[K-RAS gene mutations in patients with non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer]
Carcinoma, Non-Small-Cell Lung
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[Relationship between the protein expression of ERCC1, BRCA, ?-tubulin and K-ras and the efficacy and prognosis in advanced non-small cell lung cancer].
Carcinoma, Non-Small-Cell Lung
[Study on point mutations of K-ras gene in non-small cell lung cancer in Guangxi].
Carcinoma, Non-Small-Cell Lung
[The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.]
Carcinoma, Ovarian Epithelial
An essential role for Ran GTPase in epithelial ovarian cancer cell survival.
Carcinoma, Ovarian Epithelial
Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Carcinoma, Ovarian Epithelial
Rac GTPase activating protein 1 promotes oncogenic progression of epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
Rac1 expression in epithelial ovarian cancer: effect on cell EMT and clinical outcome.
Carcinoma, Ovarian Epithelial
ras gene activation and infrequent mutation in papillary serous carcinoma of the peritoneum.
Carcinoma, Pancreatic Ductal
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Carcinoma, Pancreatic Ductal
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Carcinoma, Pancreatic Ductal
Determination of pancreatic ductal carcinoma histogenesis by analysis of mucous quality and K-ras mutation.
Carcinoma, Pancreatic Ductal
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4.
Carcinoma, Pancreatic Ductal
Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
Carcinoma, Pancreatic Ductal
In vitro modeling of human pancreatic duct epithelial cell transformation defines gene expression changes induced by K-ras oncogenic activation in pancreatic carcinogenesis.
Carcinoma, Pancreatic Ductal
Intercalated duct cell is starting point in development of pancreatic ductal carcinoma?
Carcinoma, Pancreatic Ductal
K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
Carcinoma, Pancreatic Ductal
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
Carcinoma, Pancreatic Ductal
Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma.
Carcinoma, Pancreatic Ductal
p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors.
Carcinoma, Pancreatic Ductal
Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase.
Carcinoma, Pancreatic Ductal
The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium.
Carcinoma, Papillary
Can Different Thyroid Tumor Types Be Distinguished by Polymerase Chain Reaction-Based K-ras Mutation Detection?
Carcinoma, Papillary
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
Carcinoma, Papillary
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Carcinoma, Papillary
Prevalences of Gs alpha, ras, p53 mutations and ret/PTC rearrangement in differentiated thyroid tumours in a Korean population.
Carcinoma, Papillary
[Value of the expression of p21RAS, P53, Bcl-2 oncoproteins and Ki-67(MIB-1) antigen of cellular proliferation in the diagnosis and prognosis of thyroi]
Carcinoma, Renal Cell
Activation of the mTOR signaling pathway in renal clear cell carcinoma.
Carcinoma, Renal Cell
Author Correction: Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma, Renal Cell
Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?
Carcinoma, Renal Cell
Gene expression and protein array studies of folliculin-regulated pathways.
Carcinoma, Renal Cell
HIF-1alpha mRNA and protein upregulation involves Rho GTPase expression during hypoxia in renal cell carcinoma.
Carcinoma, Renal Cell
Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma.
Carcinoma, Renal Cell
Hypoxia up-regulates hypoxia-inducible factor-1alpha expression through RhoA activation in trophoblast cells.
Carcinoma, Renal Cell
miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.
Carcinoma, Renal Cell
miR-384 suppressed renal cell carcinoma cell proliferation and migration through targeting RAB23.
Carcinoma, Renal Cell
Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.
Carcinoma, Renal Cell
Pathology and proliferative activity of renal-cell carcinomas (RCCS) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine.
Carcinoma, Renal Cell
Proliferative heterogeneity of human renal cell carcinomas and prevalence of ras gene point mutations.
Carcinoma, Renal Cell
RAB27A is an independent prognostic factor in clear cell renal cell carcinoma.
Carcinoma, Renal Cell
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Carcinoma, Renal Cell
Splicing variant of Cdc42 interacting protein-4 disrupts beta-catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma.
Carcinoma, Renal Cell
Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo.
Carcinoma, Signet Ring Cell
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Carcinoma, Small Cell
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Carcinoma, Small Cell
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Carcinoma, Small Cell
Ovarian small cell carcinoma with K-ras mutation: a case report with genetic analysis.
Carcinoma, Small Cell
Small cell carcinoma of the gallbladder: a clinicopathologic, immunohistochemical, and molecular pathology study of 12 cases.
Carcinoma, Small Cell
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
Carcinoma, Small Cell
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Carcinoma, Squamous Cell
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Carcinoma, Squamous Cell
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Carcinoma, Squamous Cell
Age-associated inflammation connects RAS-induced senescence to stem cell dysfunction and epidermal malignancy.
Carcinoma, Squamous Cell
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
An immortalization-dependent switch in integrin function up-regulates MMP-9 to enhance tumor cell invasion.
Carcinoma, Squamous Cell
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
Carcinoma, Squamous Cell
Analysis of the K-ras and p53 pathways in X-ray-induced lung tumors in the rat.
Carcinoma, Squamous Cell
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
Carcinoma, Squamous Cell
CCL19-induced chemokine receptor 7 activates the phosphoinositide-3 kinase-mediated invasive pathway through Cdc42 in metastatic squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
CCR7 regulates cell migration and invasion through MAPKs in metastatic squamous cell carcinoma of head and neck.
Carcinoma, Squamous Cell
Circulating miR-16-5p, miR-92a-3p, and miR-451a in Plasma from Lung Cancer Patients: Potential Application in Early Detection and a Regulatory Role in Tumorigenesis Pathways.
Carcinoma, Squamous Cell
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Carcinoma, Squamous Cell
Cloning and sequencing of CATR1.3, a human gene associated with tumorigenic conversion.
Carcinoma, Squamous Cell
Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.
Carcinoma, Squamous Cell
Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis.
Carcinoma, Squamous Cell
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Carcinoma, Squamous Cell
Detection of K-ras mutations in lung carcinomas: relationship to prognosis.
Carcinoma, Squamous Cell
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Carcinoma, Squamous Cell
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Carcinoma, Squamous Cell
Distribution of p53 and K-ras mutations in human lung cancer tissues.
Carcinoma, Squamous Cell
Down-regulation of the Rho GTPase signaling pathway is involved in the microRNA-138 mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells.
Carcinoma, Squamous Cell
Enforced C-Src Activation Causes Compartmental Dysregulation of PI3K and PTEN Molecules in Lipid Rafts of Tongue Squamous Carcinoma Cells by Attenuating Rac1-Akt-GLUT-1-Mediated Sphingolipid Synthesis.
Carcinoma, Squamous Cell
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.
Carcinoma, Squamous Cell
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Carcinoma, Squamous Cell
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Carcinoma, Squamous Cell
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Expression of CDC42 in cervical squamous cell carcinoma and its correlation with clinicopathologic characteristics.
Carcinoma, Squamous Cell
Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
Carcinoma, Squamous Cell
Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
Carcinoma, Squamous Cell
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
Carcinoma, Squamous Cell
H-Ras activation and fibroblast-induced TGF-? signaling promote laminin-332 accumulation and invasion in cutaneous squamous cell carcinoma.
Carcinoma, Squamous Cell
H-ras and Nm23-H1 gene expression and proteolytic activity in squamous cell carcinoma of the uterine cervix.
Carcinoma, Squamous Cell
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
Carcinoma, Squamous Cell
High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion.
Carcinoma, Squamous Cell
Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Carcinoma, Squamous Cell
Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
Carcinoma, Squamous Cell
Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.
Carcinoma, Squamous Cell
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
Carcinoma, Squamous Cell
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
Carcinoma, Squamous Cell
K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma.
Carcinoma, Squamous Cell
K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
Carcinoma, Squamous Cell
K-ras mutations in sinonasal cancers in relation to wood dust exposure.
Carcinoma, Squamous Cell
Late occurrence of K-ras gene mutations in the pathogenesis of squamous cell carcinoma of the lung: analysis in sputum.
Carcinoma, Squamous Cell
Low incidence of point mutation at codon 12 of K-ras proto-oncogene in squamous cell carcinoma of the upper aerodigestive tract.
Carcinoma, Squamous Cell
Low levels of ras p21 oncogene expression correlates with clinical outcome in head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Carcinoma, Squamous Cell
Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent.
Carcinoma, Squamous Cell
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Carcinoma, Squamous Cell
Molecular analysis of p53 and K-ras in lung carcinomas of coal miners.
Carcinoma, Squamous Cell
Murine squamous cell carcinoma cell lines produced by a complete carcinogenesis protocol with benzo[a]pyrene exhibit characteristic p53 mutations and the absence of H-ras and cyl 1/cyclin D1 abnormalities.
Carcinoma, Squamous Cell
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Carcinoma, Squamous Cell
Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
Carcinoma, Squamous Cell
Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
Carcinoma, Squamous Cell
Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
Carcinoma, Squamous Cell
Oncogene amplification in squamous cell carcinoma of the head and neck.
Carcinoma, Squamous Cell
Oncogene amplification in squamous cell carcinoma of the oral cavity.
Carcinoma, Squamous Cell
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
Carcinoma, Squamous Cell
Overlapping functions of Ras and Rac GTPases in regulating cancer cell proliferation and invasion.
Carcinoma, Squamous Cell
pERK activation in esophageal carcinomas: clinicopathological associations.
Carcinoma, Squamous Cell
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Carcinoma, Squamous Cell
Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes.
Carcinoma, Squamous Cell
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Carcinoma, Squamous Cell
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Carcinoma, Squamous Cell
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Carcinoma, Squamous Cell
Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
Carcinoma, Squamous Cell
Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.
Carcinoma, Squamous Cell
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Carcinoma, Squamous Cell
Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin ?1/Rac1 pathway.
Carcinoma, Squamous Cell
Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form.
Carcinoma, Squamous Cell
Rare occurrence of ras and p53 gene mutations in mouse stomach tumors induced by N-methyl-N-nitrosourea.
Carcinoma, Squamous Cell
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Carcinoma, Squamous Cell
ras mutations and expression in head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Carcinoma, Squamous Cell
Small GTPase RhoE/Rnd3 Is a Critical Regulator of Notch1 Signaling.
Carcinoma, Squamous Cell
Somatic alterations of the serine/threonine kinase LKB1 gene in squamous cell (SCC) and large cell (LCC) lung carcinoma.
Carcinoma, Squamous Cell
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
Carcinoma, Squamous Cell
The identification and characterization of a GDP-dissociation inhibitor (GDI) for the CDC42Hs protein.
Carcinoma, Squamous Cell
The radiosensitivity of human keratinocytes: influence of activated c-H-ras oncogene expression and tumorigenicity.
Carcinoma, Squamous Cell
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Carcinoma, Squamous Cell
Validation of the Point-EXACCT method in non-small cell lung carcinomas.
Carcinoma, Squamous Cell
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Carcinoma, Squamous Cell
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
Carcinoma, Squamous Cell
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Carcinoma, Transitional Cell
Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population.
Carcinoma, Transitional Cell
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Carcinoma, Transitional Cell
Detection of H-ras gene point mutations in transitional cell carcinoma of human urinary bladder using polymerase chain reaction.
Carcinoma, Transitional Cell
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Carcinoma, Transitional Cell
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
Carcinoma, Transitional Cell
K-RAS mutation in transitional cell carcinoma of urinary bladder.
Carcinoma, Transitional Cell
p53 mutations in transitional cell carcinomas of the urinary bladder in rats treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine.
Carcinoma, Transitional Cell
Ras involvement in cells transformed with 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) in vitro and with N-[4-(5-nitro-2-furyl)-2-thiazoyl]formamide in vivo.
Carcinoma, Transitional Cell
Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer.
Carcinoma, Verrucous
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Carcinosarcoma
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.
Carcinosarcoma
Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors.
Carcinosarcoma
p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
Carcinosarcoma
Role of Rho, Rac, and Rho-kinase in phosphorylation of myosin light chain, development of polarity, and spontaneous migration of Walker 256 carcinosarcoma cells.
Cardiomegaly
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Cardiomegaly
Exposure to low dose benzo[a]pyrene during early life stages causes symptoms similar to cardiac hypertrophy in adult zebrafish.
Cardiomegaly
H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.
Cardiomegaly
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Cardiomegaly
Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation.
Cardiomegaly
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Cardiomegaly
Ral-GTPase interacts with the beta1 subunit of Na+/K+-ATPase and is activated upon inhibition of the Na+/K+ pump.
Cardiomegaly
Redox Signaling by 8-Nitro-cyclic Guanosine Monophosphate: Nitric Oxide- and Reactive Oxygen Species-Derived Electrophilic Messenger.
Cardiomegaly
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.
Cardiomyopathies
Increased myocardial Rab GTPase expression: a consequence and cause of cardiomyopathy.
Cardiomyopathy, Dilated
Common pathways for primary hypertrophic and dilated cardiomyopathy.
Cardiomyopathy, Dilated
Myocardial subproteomic analysis of a constitutively active Rac1-expressing transgenic mouse with lethal myocardial hypertrophy.
Cardiomyopathy, Dilated
Proteomic analysis of Rac1 transgenic mice displaying dilated cardiomyopathy reveals an increase in creatine kinase M-chain protein abundance.
Cardiomyopathy, Hypertrophic
Common pathways for primary hypertrophic and dilated cardiomyopathy.
Cardiomyopathy, Hypertrophic
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Cardiomyopathy, Hypertrophic
Proteomic Profiling of H-Ras-G12V Induced Hypertrophic Cardiomyopathy in Transgenic Mice Using Comparative LC-MS Analysis of Thin Fresh-Frozen Tissue Sections.
Cardiovascular Diseases
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Cardiovascular Diseases
Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier disease and Werner syndrome.
Cardiovascular Diseases
Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+/- haploinsufficient mice.
Cardiovascular Diseases
Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
Cardiovascular Diseases
Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.
Cardiovascular Diseases
Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.
Cardiovascular Diseases
Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.
Cardiovascular Diseases
Protein Kinase N Promotes Stress-Induced Cardiac Dysfunction Through Phosphorylation of Myocardin-Related Transcription Factor A and Disruption of Its Interaction With Actin.
Cardiovascular Diseases
Role of small GTPase protein Rac1 in cardiovascular diseases: development of new selective pharmacological inhibitors.
Cardiovascular Diseases
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Carotid Artery Injuries
Gax regulates human vascular smooth muscle cell phenotypic modulation and vascular remodeling.
Cataract
Impaired cytoskeletal organization and membrane integrity in lens fibers of a Rho GTPase functional knockout transgenic mouse.
Cataract
Loss-of-function mutations in TBC1D20 cause cataracts and male infertility in blind sterile mice and Warburg micro syndrome in humans.
Celiac Disease
Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis.
Cell Transformation, Neoplastic
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis.
Cell Transformation, Neoplastic
Enumeration of the simian virus 40 early region elements necessary for human cell transformation.
Cell Transformation, Neoplastic
FGD1 as a central regulator of extracellular matrix remodelling - lessons from faciogenital dysplasia.
Cell Transformation, Neoplastic
Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation.
Cell Transformation, Neoplastic
Rac1 is required for oncolytic NDV replication in human cancer cells and establishes a link between tumorigenesis and sensitivity to oncolytic virus.
Cell Transformation, Neoplastic
Tumorigenic transformation of primary rat embryonal fibroblasts by human papillomavirus type 8 E7 gene in collaboration with the activated H-ras gene.
Central Nervous System Diseases
Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay.
Central Nervous System Diseases
Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases.
Central Nervous System Diseases
RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia.
Central Nervous System Diseases
Rho GTPase-activating proteins: Regulators of Rho GTPase activity in neuronal development and CNS diseases.
Cerebral Hemorrhage
The 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) pathway regulates developmental cerebral-vascular stability via prenylation-dependent signalling pathway.
Cerebral Infarction
Fuyuan Xingnao Decoction Promotes Angiogenesis Through the Rab1/AT1R Pathway in Diabetes Mellitus Complicated With Cerebral Infarction.
Cerebral Infarction
Gene transfer of hepatocyte growth factor gene improves learning and memory in the chronic stage of cerebral infarction.
Cervical Intraepithelial Neoplasia
[miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells].
Charcot-Marie-Tooth Disease
Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-?6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C.
Charcot-Marie-Tooth Disease
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.
Charcot-Marie-Tooth Disease
The FGD homologue EXC-5 regulates apical trafficking in C. elegans tubules.
Chediak-Higashi Syndrome
[Defect in lytic granule exocytosis : several causes, a same effect.]
Chlamydia Infections
Rab6 and Rab11 regulate Chlamydia trachomatis development and golgin-84-dependent Golgi fragmentation.
Cholangiocarcinoma
A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor (LR).
Cholangiocarcinoma
Alterations of the p53 tumor-suppressor gene and K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area.
Cholangiocarcinoma
An integrated approach for comparative proteomic analysis of human bile reveals overexpressed cancer-associated proteins in malignant biliary stenosis.
Cholangiocarcinoma
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Cholangiocarcinoma
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.
Cholangiocarcinoma
Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
Cholangiocarcinoma
Comparison of K-ras oncogene activation in pancreatic duct carcinomas and cholangiocarcinomas induced in hamsters by N-nitrosobis(2-hydroxypropyl)amine.
Cholangiocarcinoma
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Cholangiocarcinoma
Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver.
Cholangiocarcinoma
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
Cholangiocarcinoma
K-ras Gene Mutations in Liver Carcinomas from a Mediterranean Area of Spain.
Cholangiocarcinoma
K-ras Mutation is Strongly Associated with Perineural Invasion and Represents an Independent Prognostic Factor of Intrahepatic Cholangiocarcinoma after Hepatectomy.
Cholangiocarcinoma
K-ras oncogene and p53 gene mutations in cholangiocarcinoma from Thai patients.
Cholangiocarcinoma
MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
Cholangiocarcinoma
Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Cholangiocarcinoma
Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
Cholangiocarcinoma
Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.
Cholangiocarcinoma
Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
Cholangiocarcinoma
p53?p72??225?331?V31I identified in a cholangiocarcinoma cell line promotes migration and invasiveness via the downregulation of claudin?1 expression and the activation of Cdc42.
Cholangiocarcinoma
S100P immunostaining identifies a subset of peripheral-type intrahepatic cholangiocarcinomas with morphological and molecular features similar to those of perihilar and extrahepatic cholangiocarcinomas.
Cholangiocarcinoma
The incidence of K-ras codon 12 mutations in cholangiocarcinoma detected by polymerase chain reaction technique.
Cholangiocarcinoma
[Detection of ras gene mutations of primary hepatic malignant tumors by polymerase chain reaction and direct sequencing method]
Cholangiocarcinoma
[Molecular genetic approaches in parasitology (in case of opisthorchiasis)]
Cholangitis
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
Cholangitis, Sclerosing
Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
Cholangitis, Sclerosing
K-ras mutations in the bile of patients with primary sclerosing cholangitis.
Cholecystitis
K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
Choledochal Cyst
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst.
Choledochal Cyst
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Cholelithiasis
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Cholelithiasis
Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
Cholera
?-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
Cholera
A viral K-RAS protein increases the stimulability of adenylate cyclase by cholera toxin in NRK cells.
Cholera
ADP-ribosylation factor 6 acts as an allosteric activator for the folded but not disordered cholera toxin A1 polypeptide.
Cholera
Alterations in the cyclic AMP signal transduction pathway regulating ribonucleotide reductase gene expression in malignant H-ras transformed cell lines.
Cholera
Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons.
Cholera
Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway.
Cholera
Identification of motifs in cholera toxin A1 polypeptide that are required for its interaction with human ADP-ribosylation factor 6 in a bacterial two-hybrid system.
Cholera
Ornithine decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines.
Cholera
The cholera toxin A13 subdomain is essential for interaction with ADP-ribosylation factor 6 and full toxic activity but is not required for translocation from the endoplasmic reticulum to the cytosol.
Cholestasis
Cholestasis without cirrhosis alters regulatory liver gene expression and inhibits hepatic regeneration.
Cholesteatoma
Expression of Ras-related C3 botulinum toxin substrate 1 (RAC1) in human cholesteatoma.
Chondrosarcoma
H-ras oncogene mutation in dedifferentiated chondrosarcoma: polymerase chain reaction-restriction fragment length polymorphism analysis.
Chondrosarcoma
Suppressed invasive and migratory behaviors of SW1353 chondrosarcoma cells through the regulation of Src, Rac1 GTPase, and MMP13.
Choriocarcinoma
c-myc, c-erbB-2, c-fms and bcl-2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma.
Choriocarcinoma
Dome formation induced by v-H-ras oncogene in a human choriocarcinoma cell line.
Choriocarcinoma
Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV12.
Choriocarcinoma
RhoE is regulated by cyclic AMP and promotes fusion of human BeWo choriocarcinoma cells.
Choriocarcinoma
[Roles of ras genes on biological properties of human choriocarcinoma cells]
Choroidal Neovascularization
Activation of the Small GTPase Rap1 Inhibits Choroidal Neovascularization by Regulating Cell Junctions and ROS Generation in Rats.
Choroidal Neovascularization
Optimal Inhibition of Choroidal Neovascularization by scAAV2 with VMD2 Promoter-driven Active Rap1a in the RPE.
Choroidal Neovascularization
Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization.
Choroideremia
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.
Choroideremia
Mouse genetic corneal disease resulting from transgenic insertional mutagenesis.
Choroideremia
Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.
Choroideremia
Rab GTPase prenylation hierarchy and its potential role in choroideremia disease.
Choroideremia
Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.
Choroideremia
The Biological Activity of AAV Vectors for Choroideremia Gene Therapy Can Be Measured by In Vitro Prenylation of RAB6A.
Ciliopathies
GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119.
Ciliopathies
Loss of function IFT27 variants associated with an unclassified lethal fetal ciliopathy with renal agenesis.
Ciliopathies
Lowe syndrome patient cells display mTOR- and RhoGTPase-dependent phenotypes alleviated by rapamycin and statins.
Ciliopathies
SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors.
Classical Lissencephalies and Subcortical Band Heterotopias
A Radial Glia-Specific Role of RhoA in Double Cortex Formation.
Classical Lissencephalies and Subcortical Band Heterotopias
Small Rho-GTPases and cortical malformations: Fine-tuning the cytoskeleton stability.
Classical Swine Fever
Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells.
Classical Swine Fever
Rab5, Rab7, and Rab11 Are Required for Caveola-Dependent Endocytosis of Classical Swine Fever Virus in Porcine Alveolar Macrophages.
Cleft Lip
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.
Cockayne Syndrome
Detection of UV-induced K-ras codon 12 mutation by PCR and differential dot-blot hybridization in cells from Down syndrome and Cockayne syndrome.
Coinfection
Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements.
Colitis
Coelomic Fluid of Eisenia fetida Ameliorates Cetuximab to Reduce K-Ras and Vimentin Expression through Promoting RUNX3 in an AOM/DSS-Induced Colitis Associated Colon Cancer.
Colitis
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Colitis
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Colitis
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis.
Colitis
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Colitis
RhoA and Cdc42 in T cells: Are they targetable for T cell-mediated inflammatory diseases?
Colitis
Role of the protein tyrosine phosphatase shp2 in homeostasis of the intestinal epithelium.
Colitis, Ulcerative
Activating mutations in the k-ras gene in ulcerative-colitis and crohns-disease.
Colitis, Ulcerative
Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
Colitis, Ulcerative
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Colitis, Ulcerative
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Colitis, Ulcerative
Microsatellite instability and K-ras mutations in patients with ulcerative colitis.
Colitis, Ulcerative
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Colitis, Ulcerative
Overexpression of miR-21 in patients with ulcerative colitis impairs intestinal epithelial barrier function through targeting the Rho GTPase RhoB.
Colitis, Ulcerative
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA-124-3p/STAT3/RelA signalling pathway in ulcerative colitis.
Colitis, Ulcerative
Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease.
Colitis, Ulcerative
Villous, hypermucinous mucosa in long standing ulcerative colitis shows high frequency of K-ras mutations.
Colitis, Ulcerative
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Colitis-Associated Neoplasms
Coelomic Fluid of Eisenia fetida Ameliorates Cetuximab to Reduce K-Ras and Vimentin Expression through Promoting RUNX3 in an AOM/DSS-Induced Colitis Associated Colon Cancer.
Colitis-Associated Neoplasms
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Colonic Neoplasms
12th codon mutation resulting in c-N-ras activation in acute myelogenous leukemia.
Colonic Neoplasms
A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
Colonic Neoplasms
A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.
Colonic Neoplasms
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
Colonic Neoplasms
A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells.
Colonic Neoplasms
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Colonic Neoplasms
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Colonic Neoplasms
Activated K-ras in tumorigenic and non-tumorigenic cell variants from a rat colon adenocarcinoma, induced by dimethylhydrazine.
Colonic Neoplasms
Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis.
Colonic Neoplasms
Activating mutations in the k-ras gene in ulcerative-colitis and crohns-disease.
Colonic Neoplasms
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Colonic Neoplasms
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
Colonic Neoplasms
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
Colonic Neoplasms
Anti-K-ras ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells.
Colonic Neoplasms
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Colonic Neoplasms
Association of H-ras polymorphisms and susceptibility to sporadic colon cancer.
Colonic Neoplasms
Association of K-ras mutations with p16 methylation in human colon cancer.
Colonic Neoplasms
beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.
Colonic Neoplasms
Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
Colonic Neoplasms
BMP-induced growth suppression in colon cancer cells is mediated by p21WAF1 stabilization and modulated by RAS/ERK.
Colonic Neoplasms
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.
Colonic Neoplasms
Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats.
Colonic Neoplasms
Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
Colonic Neoplasms
CD4+ T-cell immunity to mutated ras protein in pancreatic and colon cancer patients.
Colonic Neoplasms
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Colonic Neoplasms
Chromogenic in situ hybridization analysis of EGFR gene copies in colon adenocarcinoma based on intra-operative imprints and tissue microarrays.
Colonic Neoplasms
Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX.
Colonic Neoplasms
Coelomic Fluid of Eisenia fetida Ameliorates Cetuximab to Reduce K-Ras and Vimentin Expression through Promoting RUNX3 in an AOM/DSS-Induced Colitis Associated Colon Cancer.
Colonic Neoplasms
Combination of dasatinib and curcumin eliminates chemo-resistant colon cancer cells.
Colonic Neoplasms
Comparative Proteomics Analysis Identifies Cdc42-Cdc42BPA Signaling as Prognostic Biomarker and Therapeutic Target for Colon Cancer Invasion.
Colonic Neoplasms
Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
Colonic Neoplasms
Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.
Colonic Neoplasms
Conservation of the genomic structure and receptor-mediated signaling between human and rat IL-24.
Colonic Neoplasms
Cytotoxic drugs up-regulate epidermal growth factor receptor (EGFR) expression in colon cancer cells and enhance their susceptibility to EGFR-targeted antibody-dependent cell-mediated-cytotoxicity (ADCC).
Colonic Neoplasms
Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA -mediated real-time PCR clamping and mutant-specific probes.
Colonic Neoplasms
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Colonic Neoplasms
Detection of occult metastases in sentinel lymph nodes from colon cancer patients by K-ras mutation peptide nucleic acid clamp PCR.
Colonic Neoplasms
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Colonic Neoplasms
Dietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer.
Colonic Neoplasms
Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
Colonic Neoplasms
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
Colonic Neoplasms
Direct Correlation Between Double K-RAS Mutation and Mucinous Carcinoma. A Case Report.
Colonic Neoplasms
Distinguishable Prognostic Signatures of Left- and Right-Sided Colon Cancer: a Study Based on Sequencing Data.
Colonic Neoplasms
DNA mutation detection with chip-based temperature gradient capillary electrophoresis using a slantwise radiative heating system.
Colonic Neoplasms
Dose-dependent effect of dietary meat on endogenous colonic N-nitrosation.
Colonic Neoplasms
Duodenal cancer in a patient with Peutz-Jeghers syndrome: molecular analysis.
Colonic Neoplasms
Effect of the farnesyl transferase inhibitor L-744,832 on the colon cancer cell line DLD-1 and its combined use with radiation and 5-FU.
Colonic Neoplasms
ERK/pERK expression, B-raf and K-ras mutations in colon adenocarcinomas: correlation with clinicopathological characteristics and expression of hMLH1 and hMSH2.
Colonic Neoplasms
Essential role of p38gamma in K-Ras transformation independent of phosphorylation.
Colonic Neoplasms
Essential role of the JAK/STAT1 signaling pathway in the expression of inducible nitric-oxide synthase in intestinal epithelial cells and its regulation by butyrate.
Colonic Neoplasms
Evidence for a ras gene mutation in azoxymethane-induced colonic aberrant crypts in Sprague-Dawley rats: earliest recognizable precursor lesions of experimental colon cancer.
Colonic Neoplasms
Expression of facilitative glucose transporter 1 mRNA in colon cancer was not regulated by k-ras.
Colonic Neoplasms
Expression of pro-angiogenic factors as potential biomarkers in experimental models of colon cancer.
Colonic Neoplasms
Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease.
Colonic Neoplasms
From colonic polyps to colon cancer: pathophysiology, clinical presentation, screening and colonoscopic therapy.
Colonic Neoplasms
G?13/PDZ-RhoGEF/RhoA signaling is essential for gastrin-releasing peptide receptor-mediated colon cancer cell migration.
Colonic Neoplasms
Gene targeting approach to selectively kill colon cancer cells, with hyperactive K-Ras pathway.
Colonic Neoplasms
Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers.
Colonic Neoplasms
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Colonic Neoplasms
Genetic analysis of DNA excreted in urine: a new approach for detecting specific genomic DNA sequences from cells dying in an organism.
Colonic Neoplasms
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Colonic Neoplasms
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Colonic Neoplasms
Growth inhibition of a colonic adenocarcinoma cell line (HT29) by T cells specific for mutant p21 ras.
Colonic Neoplasms
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Colonic Neoplasms
Hyperprogressive Disease in an Advanced Stage Colon Cancer Patient on Pembrolizumab: A Case Report.
Colonic Neoplasms
Hypoxia activates the K-ras proto-oncogene to stimulate angiogenesis and inhibit apoptosis in colon cancer cells.
Colonic Neoplasms
Hypoxia-inducible factor-1-independent regulation of vascular endothelial growth factor by hypoxia in colon cancer.
Colonic Neoplasms
Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc.
Colonic Neoplasms
Identification and characterization of a diamine exporter in colon epithelial cells.
Colonic Neoplasms
Identification of a ternary protein-complex as a therapeutic target for K-Ras-dependent colon cancer.
Colonic Neoplasms
IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas.
Colonic Neoplasms
IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2.
Colonic Neoplasms
Impairment of K-Ras signaling networks and increased efficacy of EGFR inhibitors by a novel synthetic miR-143.
Colonic Neoplasms
Increase in the frequency of K-ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: the 1990s compared with the 1960s.
Colonic Neoplasms
Increased diacylglycerol kinase ? expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion.
Colonic Neoplasms
Induction of micronuclei by a new non-peptidic mimetic farnesyltransferase inhibitor RPR-115135: role of gene mutations.
Colonic Neoplasms
Inhibition of miR-193a Expression by Max and RXR{alpha} Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation.
Colonic Neoplasms
Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells.
Colonic Neoplasms
Interaction of molecular markers and physical activity on mortality in patients with colon cancer.
Colonic Neoplasms
Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer.
Colonic Neoplasms
Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
Colonic Neoplasms
Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).
Colonic Neoplasms
Is the Effect of Tumor Localization on Prognosis Compatible with Real-life Data in Metastatic Colon Cancer? Single-Center Experience: A Retrospective Analysis.
Colonic Neoplasms
Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
Colonic Neoplasms
Isolation of a novel member of small G protein superfamily and its expression in colon cancer.
Colonic Neoplasms
K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
Colonic Neoplasms
K-ras mutation in the major duodenal papilla and gastric and colonic mucosa in patients with autoimmune pancreatitis.
Colonic Neoplasms
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
Colonic Neoplasms
K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis.
Colonic Neoplasms
K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma.
Colonic Neoplasms
K-ras point mutations in routinely processed tissues: non-radioactive screening by single strand conformational polymorphism analysis.
Colonic Neoplasms
Kallikrein 6 is a mediator of K-RAS-dependent migration of colon carcinoma cells.
Colonic Neoplasms
KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
Colonic Neoplasms
Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways.
Colonic Neoplasms
Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice.
Colonic Neoplasms
Manumycin inhibits ras signal transduction pathway and induces apoptosis in COLO320-DM human colon tumour cells.
Colonic Neoplasms
Mast Cell Targeted Chimeric Toxin Can Be Developed as an Adjunctive Therapy in Colon Cancer Treatment.
Colonic Neoplasms
microRNA-214 functions as a tumor suppressor in human colon cancer via the suppression of ADP-ribosylation factor-like protein 2.
Colonic Neoplasms
Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.
Colonic Neoplasms
Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
Colonic Neoplasms
Mutant K-ras oncogenes in colon cancers Do not predict Patient's chemotherapy response or survival
Colonic Neoplasms
MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.
Colonic Neoplasms
N-ras protein: frequent quantitative and qualitative changes occur in human colorectal carcinomas.
Colonic Neoplasms
New peptide vaccine candidates for epithelial cancer patients with HLA-A3 supertype alleles.
Colonic Neoplasms
No back seat for a progression event-K-RAS as a therapeutic target in CRC.
Colonic Neoplasms
Nox1 is over-expressed in human colon cancers and correlates with activating mutations in K-Ras.
Colonic Neoplasms
Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.
Colonic Neoplasms
Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells.
Colonic Neoplasms
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon.
Colonic Neoplasms
Oncogenic K-ras stimulates Wnt signaling in colon cancer through inhibition of GSK-3beta.
Colonic Neoplasms
Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila.
Colonic Neoplasms
p38 MAPK activation selectively induces cell death in K-ras-mutated human colon cancer cells through regulation of vitamin D receptor.
Colonic Neoplasms
p53 Activation by Blocking Snail : A Novel Pharmacological Strategy for Cancer.
Colonic Neoplasms
p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.
Colonic Neoplasms
Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer.
Colonic Neoplasms
Phytohemagglutinin-L (PHA-L) lectin surface binding of N-linked beta 1-6 carbohydrate and its relationship to activated mutant ras in human pancreatic cancer cell lines.
Colonic Neoplasms
Primary cancer of the small intestine and mutational analysis of the K-ras and p53 genes.
Colonic Neoplasms
Prognostic role of K-ras in patients with progressive colon cancer who received treatment with Marimastat (BB2516).
Colonic Neoplasms
Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
Colonic Neoplasms
PTHrP promotes colon cancer cell migration and invasion in an integrin ?6?4-dependent manner through activation of Rac1.
Colonic Neoplasms
PTP-PEST controls motility, adherens junction assembly, and Rho GTPase activity in colon cancer cells.
Colonic Neoplasms
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Colonic Neoplasms
Rab27A mediated by NF-?B promotes the stemness of colon cancer cells via up-regulation of cytokine secretion.
Colonic Neoplasms
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Colonic Neoplasms
RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects.
Colonic Neoplasms
Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
Colonic Neoplasms
Reciprocal regulation of extracellular signal regulated kinase 1/2 and mitogen activated protein kinase phosphatase-3.
Colonic Neoplasms
Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy.
Colonic Neoplasms
Rho GTPase Rac1: molecular switch within the galectin network and for N-glycan ?2,6-sialylation/O-glycan core 1 sialylation in colon cancer in vitro.
Colonic Neoplasms
Ribozyme-mediated inactivation of mutant K-ras oncogene in a colon cancer cell line.
Colonic Neoplasms
Role of genetic polymorphisms and mutations in colorectal cancer therapy (Review).
Colonic Neoplasms
S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.
Colonic Neoplasms
Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
Colonic Neoplasms
shRNA-induced silencing of Ras-related C3 botulinum toxin substrate 1 inhibits the proliferation of colon cancer cells through upregulation of BAD and downregulation of cyclin D1.
Colonic Neoplasms
Small Molecule Destabilizer of ?-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors.
Colonic Neoplasms
Sprouty-2 controls c-Met expression and metastatic potential of colon cancer cells: sprouty/c-Met upregulation in human colonic adenocarcinomas.
Colonic Neoplasms
STAT1 Represses Skp2 Gene Transcription to Promote p27Kip1 Stabilization in Ras-Transformed Cells.
Colonic Neoplasms
Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Colorectal Cancer: A Curative Option.
Colonic Neoplasms
Suppression of pancreatic and colon cancer cells by antisense K-ras RNA expression vectors.
Colonic Neoplasms
Targeted disruption of the K-ras oncogene in an invasive colon cancer cell line down-regulates urokinase receptor expression and plasminogen-dependent proteolysis.
Colonic Neoplasms
Targeted Intestinal Deletion of Rho Guanine Nucleotide Exchange Factor 7, ?PIX, Impairs Enterocyte Proliferation, Villus Maturation and Mucosal Defenses in Mice.
Colonic Neoplasms
Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
Colonic Neoplasms
Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer.
Colonic Neoplasms
Testosterone induced apoptosis in colon cancer cells is regulated by PI3K/Rac1 signaling.
Colonic Neoplasms
The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras.
Colonic Neoplasms
The Critical Role of Dysregulated RhoB Signaling Pathway in Radioresistance of Colorectal Cancer.
Colonic Neoplasms
The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance.
Colonic Neoplasms
The role of ras gene mutation in gastric cancer and precancerous lesions.
Colonic Neoplasms
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres.
Colonic Neoplasms
Transforming growth factor-beta1 modulates metalloproteinase-2 and -9, nitric oxide, RhoA and alpha-smooth muscle actin expression in colon adenocarcinoma cells.
Colonic Neoplasms
Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Colonic Neoplasms
Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use.
Colonic Neoplasms
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Colonic Neoplasms
Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer.
Colonic Neoplasms
Ursodeoxycholic acid inhibits Ras mutations, wild-type Ras activation, and cyclooxygenase-2 expression in colon cancer.
Colonic Neoplasms
Use of isogenic human cancer cells for high-throughput screening and drug discovery.
Colonic Neoplasms
Wnt signaling can repress thrombospondin-1 expression in colonic tumorigenesis.
Colonic Neoplasms
[A case of liver metastasis treated by cetuximab monotherapy with partial response]
Colonic Neoplasms
[CD4+ T-cell immunity and Ab responses to mutant ras protein in pancreas and colon cancer patients]
Colonic Neoplasms
[Detection of K-ras mutations in colon cancer by PHA-PHFA (preferential homoduplex formation assay)]
Colonic Neoplasms
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
Colonic Neoplasms
[Effects of K-ras gene mutation on colon cancer cell line Caco-2 metastasis by regulating E-cadherin/beta-catenin/p120 protein complex formation and RhoA protein activity]
Colonic Neoplasms
[K-ras mutational status and tumour-infiltrating lymphocytes in human colon cancer: state of the art and future perspectives].
Colonic Neoplasms
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
Colonic Neoplasms
[The effect of small GTPase Cdc42 on the multidrug resistance of oxaliplatin-resistant colon cancer cell lines].
Colonic Neoplasms
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
Colorectal Neoplasms
5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.
Colorectal Neoplasms
?-catenin and K-ras mutations and RASSF1A promoter methylation in Taiwanese colorectal cancer patients.
Colorectal Neoplasms
?Np63? suppresses cells invasion by downregulating PKC?/Rac1 signaling through miR-320a.
Colorectal Neoplasms
A case of syncronised hereditery nonpoliposis colorectal tumor with different hystopathological type and k-ras gene mutation: case report.
Colorectal Neoplasms
A colorimetric method for point mutation detection using high-fidelity DNA ligase.
Colorectal Neoplasms
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
Colorectal Neoplasms
A detailed analysis of the role of K-ras gene mutation in the progression of colorectal adenoma.
Colorectal Neoplasms
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
Colorectal Neoplasms
A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?
Colorectal Neoplasms
A miniaturized spatial temperature gradient capillary electrophoresis system with radiative heating and automated sample introduction for DNA mutation detection.
Colorectal Neoplasms
A newly identified pattern of K-ras mutations at codons 12 and 13 is associated with long-term survival in colorectal cancer.
Colorectal Neoplasms
A novel gene containing PDZ and LIM domains, PCD1, is overexpressed in human colorectal cancer.
Colorectal Neoplasms
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
Colorectal Neoplasms
A novel K-ras mutation in colorectal cancer. A case report and literature review.
Colorectal Neoplasms
A novel mutant allele specific amplification and electrochemiluminescence method for the detection of point mutation in clinical samples.
Colorectal Neoplasms
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
Colorectal Neoplasms
A rapid PCR ELISA for the detection of activated K-ras in colorectal cancer.
Colorectal Neoplasms
A relationship between K-ras gene mutations and some clinical and histologic variables in patients with primary colorectal carcinoma.
Colorectal Neoplasms
A sensitive fluorescence anisotropy method for point mutation detection by using core-shell fluorescent nanoparticles and high-fidelity DNA ligase.
Colorectal Neoplasms
A simple method of detecting K-ras point mutations in stool samples for colorectal cancer screening using one-step polymerase chain reaction/restriction fragment length polymorphism analysis.
Colorectal Neoplasms
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
Colorectal Neoplasms
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Colorectal Neoplasms
Acquisition of anoikis resistance promotes the emergence of oncogenic K-ras mutations in colorectal cancer cells and stimulates their tumorigenicity in vivo.
Colorectal Neoplasms
Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.
Colorectal Neoplasms
Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations.
Colorectal Neoplasms
Activation of K-RAS by co-mutation of codons 19 and 20 is transforming.
Colorectal Neoplasms
Activation of Rho GTPase Cdc42 promotes adhesion and invasion in colorectal cancer cells.
Colorectal Neoplasms
Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis.
Colorectal Neoplasms
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Colorectal Neoplasms
Advances in Molecular Pathology and Treatment of Periampullary Cancers.
Colorectal Neoplasms
Ag3PO4 NP@MoS2 nanosheet enhanced F, S-doped BN quantum dot electrochemiluminescence biosensor for K-ras tumor gene detection.
Colorectal Neoplasms
Age-associated loss of heterozygosity of tumor suppressor genes in the gastric mucosa of humans.
Colorectal Neoplasms
Agreement between K-ras sequence variations detected in plasma and tissue DNA in pancreatic and colorectal cancer.
Colorectal Neoplasms
AKAP-9 promotes colorectal cancer development by regulating Cdc42 interacting protein 4.
Colorectal Neoplasms
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.
Colorectal Neoplasms
Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe.
Colorectal Neoplasms
Alterations of p53 and k-ras genes in human colorectal-cancer with ulcerative-colitis.
Colorectal Neoplasms
Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas.
Colorectal Neoplasms
Amplification refractory mutation system linear extension: a novel, gel-free, enzyme-linked immunoassay method for DNA genotyping.
Colorectal Neoplasms
Analysis of HER-3, insulin growth factor-1, nuclear factor-kB and epidermal growth factor receptor gene copy number in the prediction of clinical outcome for K-RAS wild-type colorectal cancer patients receiving irinotecan-cetuximab.
Colorectal Neoplasms
Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.
Colorectal Neoplasms
Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule-aggregating tumors.
Colorectal Neoplasms
Analysis of mutant K-ras in multiple sites of normal appearing mucosa of colorectal cancer patients.
Colorectal Neoplasms
Analysis of potential predictive markers of cetuximab benefit in BMS099, a phase III study of cetuximab and first-line taxane/carboplatin in advanced non-small-cell lung cancer.
Colorectal Neoplasms
Analysis of the anatomic subsites, gender and age in unresectable advanced colorectal carcinomas in Tochigi, Japan suggests a shift in location towards the right side colon in elderly patients treated with cetuximab.
Colorectal Neoplasms
Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
Colorectal Neoplasms
APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.
Colorectal Neoplasms
APC mutations are sufficient for the growth of early colorectal adenomas.
Colorectal Neoplasms
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Colorectal Neoplasms
Application of cycling gradient capillary electrophoresis to detection of APC, K-ras, and DCC point mutations in patients with sporadic colorectal tumors.
Colorectal Neoplasms
Approaching real-time molecular diagnostics: single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes.
Colorectal Neoplasms
Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer?
Colorectal Neoplasms
Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer.
Colorectal Neoplasms
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer.
Colorectal Neoplasms
Association of folate intake, dietary habits, smoking and COX-2 promotor -765G>C polymorphism with K-ras mutation in patients with colorectal cancer.
Colorectal Neoplasms
Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.
Colorectal Neoplasms
Association of K-ras mutations with liver metastases from colorectal carcinoma.
Colorectal Neoplasms
Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab.
Colorectal Neoplasms
Association of KRAS gene mutations with depression in older metastatic colorectal cancer patients.
Colorectal Neoplasms
Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.
Colorectal Neoplasms
Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.
Colorectal Neoplasms
Biweekly cetuximab and first-line chemotherapy in chinese patients with k-ras wild-type colorectal cancers.
Colorectal Neoplasms
Can K-ras gene mutation be utilized as prognostic biomarker for colorectal cancer patients receiving chemotherapy? A meta-analysis and systematic review.
Colorectal Neoplasms
Carfilzomib Promotes the Unfolded Protein Response and Apoptosis in Cetuximab-Resistant Colorectal Cancer.
Colorectal Neoplasms
Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.
Colorectal Neoplasms
CDC42 inhibition suppresses progression of incipient intestinal tumors.
Colorectal Neoplasms
Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
Colorectal Neoplasms
Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.
Colorectal Neoplasms
cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer.
Colorectal Neoplasms
Cetuximab in the first-line treatment of K-ras wild-type metastatic colorectal cancer: the choice and schedule of fluoropyrimidine matters.
Colorectal Neoplasms
Cetuximab rechallenge in metastatic colorectal cancer patients: how to come away from acquired resistance?
Colorectal Neoplasms
Cetuximab-based therapy for metastatic colorectal cancer: a meta-analysis of the effect of K-ras mutations.
Colorectal Neoplasms
Characteristics in primary signet-ring cell carcinoma of the colorectum, from clinicopathological observations.
Colorectal Neoplasms
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Colorectal Neoplasms
Clinical impact of K-ras mutation in colorectal cancer patients treated with adjuvant FOLFOX.
Colorectal Neoplasms
Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.
Colorectal Neoplasms
Clinical retrospective study on the expression of the PD-L1 molecule in sporadic colorectal cancer and its correlation with K-ras gene mutations in Chinese patients.
Colorectal Neoplasms
Clinical significance of K-ras and BRAF mutations in Chinese colorectal cancer patients.
Colorectal Neoplasms
Clinical significance of K-Ras mutations in intraoperative tumor drainage blood from patients with colorectal carcinoma.
Colorectal Neoplasms
Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers.
Colorectal Neoplasms
Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.
Colorectal Neoplasms
Clinical validation of colorectal cancer biomarkers identified from bioinformatics analysis of public expression data.
Colorectal Neoplasms
Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.
Colorectal Neoplasms
Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia.
Colorectal Neoplasms
Clinico-Pathological Study of K-ras Mutations in Colorectal Tumors: A Single-Center Retrospective Study of 51 Patients in Madinah, Saudi Arabia.
Colorectal Neoplasms
Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection.
Colorectal Neoplasms
Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis.
Colorectal Neoplasms
Clinicopathological Associations of K-RAS and N-RAS Mutations in Indonesian Colorectal Cancer Cohort.
Colorectal Neoplasms
Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers.
Colorectal Neoplasms
Colonic Paneth cell metaplasia is pre-neoplastic condition of colonic cancer or not?
Colorectal Neoplasms
Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability.
Colorectal Neoplasms
Colorectal cancer: using blood samples and tumor tissue to detect K-ras mutations.
Colorectal Neoplasms
Combined analysis of microsatellite instability and K-ras mutation increases detection incidence of normal samples from colorectal cancer patients.
Colorectal Neoplasms
Comparative Screening of K-ras Mutations in Colorectal Cancer and Lung Cancer Patients Using a Novel Real-Time PCR with ADx-K-ras Kit and Sanger DNA Sequencing.
Colorectal Neoplasms
Comparative study of mutations in SNP loci of K-RAS, hMLH1 and hMSH2 genes in neoplastic intestinal polyps and colorectal cancer.
Colorectal Neoplasms
Comparison of a PNA clamp PCR and an ARMS/Scorpion PCR assay for the detection of K-ras mutations.
Colorectal Neoplasms
Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old.
Colorectal Neoplasms
Concurrent mutation in exons 1 and 2 of the K-ras oncogene in colorectal cancer.
Colorectal Neoplasms
Concurrent mutations of K-ras oncogene at codons 12 and 22 in colon cancer.
Colorectal Neoplasms
Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients.
Colorectal Neoplasms
Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity.
Colorectal Neoplasms
Correlation of K-ras codon 12 mutations in human feces and ages of patients with colorectal cancer (CRC).
Colorectal Neoplasms
Corrigendum: Tetrac and NDAT Induce Anti-proliferation via Integrin ?v?3 in Colorectal Cancers With Different K-RAS Status.
Colorectal Neoplasms
Cost-effectiveness of targeted therapy with cetuximab in patients with K-ras wild-type colorectal cancer presenting with initially unresectable metastases limited to the liver in a German setting.
Colorectal Neoplasms
CpG island promoter hypermethylation of a novel Ras-effector gene RASSF2A is an early event in colon carcinogenesis and correlates inversely with K-ras mutations.
Colorectal Neoplasms
Critical Role of p53 and K-ras in the Diagnosis of Early Colorectal Cancer: a One-year, Single-center Analysis.
Colorectal Neoplasms
CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
Colorectal Neoplasms
Cyclin D1 overexpression in colorectal carcinoma in vivo is dependent on beta-catenin protein dysregulation, but not k-ras mutation.
Colorectal Neoplasms
Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas.
Colorectal Neoplasms
Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer.
Colorectal Neoplasms
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion.
Colorectal Neoplasms
Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer.
Colorectal Neoplasms
Detection of a K-ras mutation in urine of patients with colorectal cancer.
Colorectal Neoplasms
Detection of APC and k-ras mutations in the serum of patients with colorectal cancer.
Colorectal Neoplasms
Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.
Colorectal Neoplasms
Detection of colorectal cancer K-ras mutations using a simplified oligonucleotide ligation assay.
Colorectal Neoplasms
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
Colorectal Neoplasms
Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.
Colorectal Neoplasms
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Colorectal Neoplasms
Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
Colorectal Neoplasms
Detection of K-ras Mutations in Predicting Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR-TK) Inhibitor in Patients with Metastatic Colorectal Cancer.
Colorectal Neoplasms
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
Colorectal Neoplasms
Detection of K-ras point mutations in mesenteric venous blood from colorectal cancer patients by enriched polymerase chain reaction and single-strand conformation polymorphism analysis.
Colorectal Neoplasms
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Colorectal Neoplasms
Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer.
Colorectal Neoplasms
Detection of mutated K-ras DNA in urine, plasma, and serum of patients with colorectal carcinoma or adenomatous polyps.
Colorectal Neoplasms
Detection of oncogene mutation from neoplastic colonic cells exfoliated in feces.
Colorectal Neoplasms
Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
Colorectal Neoplasms
Detection of tumor cells in blood using CD45 magnetic cell separation followed by nested mutant allele-specific amplification of p53 and K-ras genes in patients with colorectal cancer.
Colorectal Neoplasms
Determination of Circulating Tumor Cells for Prediction of Recurrent Colorectal Cancer Progression.
Colorectal Neoplasms
Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival.
Colorectal Neoplasms
Development of a ligase detection reaction/CGE method using a LIF dual-channel detection system for direct identification of allelic composition of mutated DNA in a mixed population of excess wild-type DNA.
Colorectal Neoplasms
Diagnostic biochip array for fast and sensitive detection of K-ras mutations in stool.
Colorectal Neoplasms
Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
Colorectal Neoplasms
Differences in gene mutations according to gender among patients with colorectal cancer.
Colorectal Neoplasms
Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method.
Colorectal Neoplasms
Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.
Colorectal Neoplasms
Different types of K-Ras mutations are conversely associated with overall survival in patients with colorectal cancer.
Colorectal Neoplasms
Differential colorectal carcinogenesis: Molecular basis and clinical relevance.
Colorectal Neoplasms
Differential Expression of IL-17, 22 and 23 in the Progression of Colorectal Cancer in Patients with K-ras Mutation: Ras Signal Inhibition and Crosstalk with GM-CSF and IFN-?.
Colorectal Neoplasms
Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries.
Colorectal Neoplasms
Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.
Colorectal Neoplasms
Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13.
Colorectal Neoplasms
Discriminative detection of low-abundance point mutations using a PCR/ligase detection reaction/capillary gel electrophoresis method and fluorescence dual-channel monitoring.
Colorectal Neoplasms
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Colorectal Neoplasms
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Colorectal Neoplasms
Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.
Colorectal Neoplasms
Distribution of genetic variants in preneoplastic areas of colorectal tumours.
Colorectal Neoplasms
DNA alkylation and repair in the large bowel: animal and human studies.
Colorectal Neoplasms
DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system.
Colorectal Neoplasms
DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.
Colorectal Neoplasms
Does increased endogenous formation of N-nitroso compounds in the human colon explain the association between red meat and colon cancer?
Colorectal Neoplasms
Down-regulation of Cdx2 in colorectal carcinoma cells by the Raf-MEK-ERK 1/2 pathway.
Colorectal Neoplasms
Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer.
Colorectal Neoplasms
Early FDG/PET scanning as a pharmacodynamic marker of anti-EGFR antibody activity in colorectal cancer.
Colorectal Neoplasms
Early prediction by 18F-FDG PET/CT for progression-free survival and overall survival in patients with metastatic colorectal cancer receiving third-line cetuximab-based therapy.
Colorectal Neoplasms
Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: relationship to distribution of proliferating cells.
Colorectal Neoplasms
Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer.
Colorectal Neoplasms
EGFR-targeted TRAIL and a Smac mimetic synergize to overcome apoptosis resistance in KRAS mutant colorectal cancer cells.
Colorectal Neoplasms
Electrochemical biosensor based on functional composite nanofibers for detection of K-ras gene via multiple signal amplification strategy.
Colorectal Neoplasms
Eligibility of real-world patients with chemo-refractory, K-RAS wild-type, metastatic colorectal cancer for palliative intent regorafenib monotherapy.
Colorectal Neoplasms
EP4 upregulation of Ras signaling and feedback regulation of Ras in human colon tissues and cancer cells.
Colorectal Neoplasms
Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis.
Colorectal Neoplasms
Epidermal growth factor receptor (EGFR) status and K-Ras mutations in colorectal cancer.
Colorectal Neoplasms
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Colorectal Neoplasms
Epigenetic activation of the small GTPase TCL contributes to colorectal cancer cell migration and invasion.
Colorectal Neoplasms
Epiregulin gene expression as a biomarker of benefit from cetuximab in the treatment of advanced colorectal cancer.
Colorectal Neoplasms
Ethnic difference in the pattern of K-ras oncogene mutations in human colorectal cancers.
Colorectal Neoplasms
Evaluating the treatment of metastatic colorectal cancer with monoclonal antibodies.
Colorectal Neoplasms
Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer.
Colorectal Neoplasms
Expression of cytosolic and group X secretory phospholipase A(2) genes in human colorectal adenocarcinomas.
Colorectal Neoplasms
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.
Colorectal Neoplasms
Extended staging results from the detection of isolated tumor cells in the liver of colorectal cancer patients.
Colorectal Neoplasms
Fabrication of DNA microarrays onto polymer substrates using UV modification protocols with integration into microfluidic platforms for the sensing of low-abundant DNA point mutations.
Colorectal Neoplasms
Factors influencing the detection of mutant K-ras in the serum of patients with colorectal cancer.
Colorectal Neoplasms
Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Colorectal Neoplasms
Frequency and clinico-pathological associations of ras mutations in colorectal cancer in the Victorian population.
Colorectal Neoplasms
Frequency and clinicopathology associations of K-ras mutations in colorectal cancer in a northeast Mexican population.
Colorectal Neoplasms
Frequency and spectrum of K-RAS codons 12 and 13 mutations in colorectal adenocarcinomas from Taiwan.
Colorectal Neoplasms
Frequency of K-RAS and N-RAS Gene Mutations in Colorectal Cancers in Southeastern Iran
Colorectal Neoplasms
Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
Colorectal Neoplasms
Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: comparison with tissue samples.
Colorectal Neoplasms
Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors.
Colorectal Neoplasms
Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
Colorectal Neoplasms
Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene.
Colorectal Neoplasms
Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
Colorectal Neoplasms
Genetic abnormalities and microsatellite instability in colorectal cancer.
Colorectal Neoplasms
Genetic alterations in colorectal cancer, comparative analysis of deletion events, and point mutations.
Colorectal Neoplasms
Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
Colorectal Neoplasms
Genetic alterations of APC, K-ras, p53, MSI, and MAGE in Korean colorectal cancer patients.
Colorectal Neoplasms
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Colorectal Neoplasms
Genetic and biochemical changes in colorectal carcinoma in relation to morphologic characteristics.
Colorectal Neoplasms
Genetic detection of colorectal cancer cells in circulation and lymph nodes.
Colorectal Neoplasms
Genetic detection of lymph node micrometastases: a selection criterion for liver transplantation in patients with liver metastases after colorectal cancer.
Colorectal Neoplasms
Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
Colorectal Neoplasms
Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer.
Colorectal Neoplasms
Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
Colorectal Neoplasms
Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras.
Colorectal Neoplasms
Genotyping of K-ras codons 12 and 13 mutations in colorectal cancer by capillary electrophoresis.
Colorectal Neoplasms
Glutathione S-transferase-pi overexpression is closely associated with K-ras mutation during human colon carcinogenesis.
Colorectal Neoplasms
Greater frequency of K-ras Val-12 mutation in colorectal cancer as detected with sensitive methods.
Colorectal Neoplasms
H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.
Colorectal Neoplasms
Hematologic toxicity assessment in solid tumor patients treated with cetuximab: A pooled analysis of 18 randomized controlled trials.
Colorectal Neoplasms
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Colorectal Neoplasms
High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
Colorectal Neoplasms
High nuclear expression of phosphorylated extracellular signal-regulated kinase in tumor cells in colorectal glands is associated with poor outcome in colorectal cancer.
Colorectal Neoplasms
High sensitivity scanning of colorectal tumors and matched plasma DNA for mutations in APC, TP53, K-RAS, and BRAF genes with a novel DHPLC fluorescence detection platform.
Colorectal Neoplasms
High-content screening Raman spectroscopy (HCS-RS) of panitumumab-exposed colorectal cancer cells.
Colorectal Neoplasms
High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
Colorectal Neoplasms
HMGB1-RAGE signaling facilitates Ras-dependent Yap1 expression to drive colorectal cancer stemness and development.
Colorectal Neoplasms
Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.
Colorectal Neoplasms
Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer.
Colorectal Neoplasms
Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor.
Colorectal Neoplasms
Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.
Colorectal Neoplasms
Identification of Rho GTPase Activating Protein 6 Isoform 1 Variant as a New Molecular Marker in Human Colorectal Tumors.
Colorectal Neoplasms
Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool.
Colorectal Neoplasms
Immunohistochemical assay for detection of K-ras protein expression in metastatic colorectal cancer.
Colorectal Neoplasms
Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation.
Colorectal Neoplasms
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
Colorectal Neoplasms
Impact of Cellular Genetic Make-up on Colorectal Cancer Cell Lines Response to Ellagic Acid: Implications of Small Interfering RNA.
Colorectal Neoplasms
Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells.
Colorectal Neoplasms
Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.
Colorectal Neoplasms
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Colorectal Neoplasms
Increase in the frequency of K-ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: the 1990s compared with the 1960s.
Colorectal Neoplasms
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
Colorectal Neoplasms
Increased farnesyltransferase activity in human colorectal cancer: relationship with clinicopathological features and K-ras mutation.
Colorectal Neoplasms
Individualization of therapy for colorectal cancer based on clinical and molecular parameters.
Colorectal Neoplasms
Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.
Colorectal Neoplasms
Influence of age on adenomatous polyposis coli and p53 mutation frequency in sporadic colorectal cancer-rarity of co-occurrence of mutations in APC, K-ras, and p53 genes.
Colorectal Neoplasms
Influence of K-ras status and anti-tumour treatments on complications due to colorectal self-expandable metallic stents: A retrospective multicentre study.
Colorectal Neoplasms
Infrequent inactivation of DCC gene in replication error-positive colorectal cancers.
Colorectal Neoplasms
Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
Colorectal Neoplasms
Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation.
Colorectal Neoplasms
Initial Report of Phase II Study on Bi-weekly SOX plus Cetuximab Treatment for Wild-type K-RAS Advanced and Recurrent Colorectal Cancer.
Colorectal Neoplasms
Ink4a/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis.
Colorectal Neoplasms
Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan.
Colorectal Neoplasms
Interlaboratory comparison of K-ras testing by real-time PCR and RFLP in colorectal cancer samples.
Colorectal Neoplasms
Involvement of Activated Cdc42 Kinase1 in Colitis and Colorectal Neoplasms.
Colorectal Neoplasms
Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
Colorectal Neoplasms
Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma.
Colorectal Neoplasms
Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
Colorectal Neoplasms
Is availability of anti-EGFR therapy for the colorectal adenocarcinomas showing fascin expression limited?
Colorectal Neoplasms
Is K-ras gene mutation a prognostic factor for colorectal cancer: a systematic review and meta-analysis.
Colorectal Neoplasms
Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression.
Colorectal Neoplasms
K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
Colorectal Neoplasms
K-ras activation in colorectal tumors from patients with familial polyposis coli.
Colorectal Neoplasms
K-ras and B-raf gene mutations are not associated with gastrin- and CCK2-receptor mRNA expression in human colorectal tumour tissues.
Colorectal Neoplasms
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.
Colorectal Neoplasms
K-ras and p53 gene mutations in colorectal cancer in 57 Japanese patients.
Colorectal Neoplasms
K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma.
Colorectal Neoplasms
K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
Colorectal Neoplasms
K-ras and p53 mutations in DNA extracted from colonic epithelial cells exfoliated in faeces of patients with colorectal cancer.
Colorectal Neoplasms
K-ras and p53 mutations in hereditary non-polyposis colorectal cancers.
Colorectal Neoplasms
K-Ras and sensitivity to EGFR inhibitors in metastatic colorectal cancer.
Colorectal Neoplasms
K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
Colorectal Neoplasms
K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients.
Colorectal Neoplasms
K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
Colorectal Neoplasms
K-ras gene mutation in colorectal adenomas and carcinomas from familial adenomatous polyposis patients.
Colorectal Neoplasms
K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers.
Colorectal Neoplasms
K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy.
Colorectal Neoplasms
K-ras gene mutation status in colorectal cancer: comparative analysis of pyrosequencing and PCR-RFLP.
Colorectal Neoplasms
K-ras gene mutations in early colorectal cancer ... flat elevated vs polyp-forming cancer....
Colorectal Neoplasms
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
Colorectal Neoplasms
K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients.
Colorectal Neoplasms
K-ras mutation and loss of heterozygosity of chromosome 17p and survival in colorectal cancer.
Colorectal Neoplasms
K-ras mutation detection in colorectal cancer using the Pyrosequencing technique.
Colorectal Neoplasms
K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
Colorectal Neoplasms
K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
Colorectal Neoplasms
K-Ras mutation status as a predictive biomarker in metastatic colorectal cancer.
Colorectal Neoplasms
K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer.
Colorectal Neoplasms
K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
Colorectal Neoplasms
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
Colorectal Neoplasms
K-ras mutations (codon 12) are not involved in down-regulation of MHC class-I genes in colon carcinomas.
Colorectal Neoplasms
K-ras mutations and benefit from cetuximab in advanced colorectal cancer.
Colorectal Neoplasms
K-ras mutations and cetuximab in colorectal cancer.
Colorectal Neoplasms
K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
Colorectal Neoplasms
K-ras mutations and RASSF1A promoter methylation in colorectal cancer.
Colorectal Neoplasms
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Colorectal Neoplasms
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
Colorectal Neoplasms
K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.
Colorectal Neoplasms
K-ras Mutations as the Earliest Driving Force in a Subset of Colorectal Carcinomas.
Colorectal Neoplasms
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
Colorectal Neoplasms
K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
Colorectal Neoplasms
K-ras mutations in sporadic colorectal tumors in Israel: unusual high frequency of codon 13 mutations and evidence for nonhomogeneous representation of mutation subtypes.
Colorectal Neoplasms
K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients with left-sided colorectal carcinoma.
Colorectal Neoplasms
K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Colorectal Neoplasms
K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis.
Colorectal Neoplasms
K-ras status does not predict successful hepatic resection of colorectal cancer metastasis.
Colorectal Neoplasms
Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
Colorectal Neoplasms
KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression.
Colorectal Neoplasms
Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.
Colorectal Neoplasms
KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer.
Colorectal Neoplasms
Laser pressure catapulting (LPC): optimization LPC-system and genotyping of colorectal carcinomas.
Colorectal Neoplasms
Ligase detection reaction for the analysis of point mutations using free-solution conjugate electrophoresis in a polymer microfluidic device.
Colorectal Neoplasms
Long noncoding RNA UCA1 enhances sensitivity to oncolytic vaccinia virus by sponging miR-18a/miR-182 and modulating the Cdc42/filopodia axis in colorectal cancer.
Colorectal Neoplasms
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
Colorectal Neoplasms
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
Colorectal Neoplasms
Loss of heterozygosity at the human RAP1A/Krev-1 locus is a rare event in colorectal tumors.
Colorectal Neoplasms
Loss of RASSF1A expression in colorectal cancer and its association with K-ras status.
Colorectal Neoplasms
Low Gene Dosage of Cdc42 Is Not Associated with Protein Dysfunction in Patients with Colorectal Cancer.
Colorectal Neoplasms
Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.
Colorectal Neoplasms
Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years.
Colorectal Neoplasms
Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts.
Colorectal Neoplasms
Macrophages stimulate gastric and colorectal cancer invasion through EGFR Y(1086), c-Src, Erk1/2 and Akt phosphorylation and smallGTPase activity.
Colorectal Neoplasms
Malignant transformation of rat embryo fibroblasts by cotransfection with eleven human mutant p53 cDNAs and activated H-ras gene.
Colorectal Neoplasms
MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
Colorectal Neoplasms
Melting temperature analysis as quantitative method for detection of point mutations.
Colorectal Neoplasms
Metastatic colorectal cancer first-line treatment with bevacizumab: the impact of K-ras mutation.
Colorectal Neoplasms
Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
Colorectal Neoplasms
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.
Colorectal Neoplasms
MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B.
Colorectal Neoplasms
MicroRNA-101 suppresses colorectal cancer progression by negative regulation of Rap1b.
Colorectal Neoplasms
MicroRNA-224 suppresses colorectal cancer cell migration by targeting Cdc42.
Colorectal Neoplasms
MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b.
Colorectal Neoplasms
MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
Colorectal Neoplasms
Microsatellite instability in colorectal adenocarcinoma cell lines that have full-length adenomatous polyposis coli protein.
Colorectal Neoplasms
miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells.
Colorectal Neoplasms
miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
Colorectal Neoplasms
miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells.
Colorectal Neoplasms
miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation.
Colorectal Neoplasms
miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42.
Colorectal Neoplasms
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42.
Colorectal Neoplasms
MiR-622 inhibited colorectal cancer occurrence and metastasis by suppressing K-Ras.
Colorectal Neoplasms
Modified mismatch polymerase chain reaction-restriction fragment length polymorphism detected mutations in codon 12 and 13 of exon 2 of K-
Colorectal Neoplasms
Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
Colorectal Neoplasms
Molecular detection (k-ras) of exfoliated tumour cells in the pelvis is a prognostic factor after resection of rectal cancer?
Colorectal Neoplasms
Molecular detection of codon 12 K-RAS mutations in circulating DNA from serum of colorectal cancer patients.
Colorectal Neoplasms
Molecular detection of genetic alterations in the serum of colorectal cancer patients.
Colorectal Neoplasms
Molecular mechanisms underlying the tumorigenesis of colorectal adenomas: correlation to activated K-ras oncogene.
Colorectal Neoplasms
Molecular profiling of sporadic colorectal tumors by microsatellite analysis.
Colorectal Neoplasms
Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients.
Colorectal Neoplasms
Morphological and molecular heterogeneity in colorectal neoplasms with K-RAS mutation. A report of two cases.
Colorectal Neoplasms
mTOR-independent 4E-BP1 phosphorylation is associated with cancer resistance to mTOR kinase inhibitors.
Colorectal Neoplasms
Multiplex PCR/LDR for detection of K-ras mutations in primary colon tumors.
Colorectal Neoplasms
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
Colorectal Neoplasms
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.
Colorectal Neoplasms
Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis.
Colorectal Neoplasms
Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
Colorectal Neoplasms
Mutant K-ras regulates cathepsin B localization on the surface of human colorectal carcinoma cells.
Colorectal Neoplasms
Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.
Colorectal Neoplasms
Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.
Colorectal Neoplasms
Mutation in the K-ras gene at codon 12 does not correlate with disease progression in colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy.
Colorectal Neoplasms
Mutation of beta-catenin does not coexist with K-ras mutation in colorectal tumorigenesis.
Colorectal Neoplasms
Mutation pattern of K-ras gene in colorectal cancer patients of Kashmir: a report.
Colorectal Neoplasms
Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.
Colorectal Neoplasms
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
Colorectal Neoplasms
Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes.
Colorectal Neoplasms
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Colorectal Neoplasms
Mutations in K-ras and Epidermal Growth Factor Receptor Expression in Korean Patients With Stages III and IV Colorectal Cancer.
Colorectal Neoplasms
Mutations of p53 and K-ras correlate TF expression in human colorectal carcinomas: TF downregulation as a marker of poor prognosis.
Colorectal Neoplasms
MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.
Colorectal Neoplasms
MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.
Colorectal Neoplasms
NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.
Colorectal Neoplasms
NAT2 fast acetylator genotype and MGMT promoter methylation may contribute to gender difference in K-RAS mutation occurrence in Taiwanese colorectal cancer.
Colorectal Neoplasms
Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations.
Colorectal Neoplasms
NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity.
Colorectal Neoplasms
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
Colorectal Neoplasms
No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer.
Colorectal Neoplasms
Noninvasive detection through REMS-PCR technique of K-ras mutations in stool DNA of patients with colorectal cancer.
Colorectal Neoplasms
Not infrequent K-ras mutations in depressed-type early colorectal carcinomas larger than 10 mm.
Colorectal Neoplasms
Novel approach to abuse the hyperactive K-Ras pathway for adenoviral gene therapy of colorectal cancer.
Colorectal Neoplasms
Nuclear beta-catenin expression is closely related to ulcerative growth of colorectal carcinoma.
Colorectal Neoplasms
O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions.
Colorectal Neoplasms
O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.
Colorectal Neoplasms
O6-methylguanine-DNA methyltransferase Leu84Phe and Ile143Val polymorphisms and risk of colorectal cancer in the Nurses' Health Study and Physicians' Health Study (United States).
Colorectal Neoplasms
Oligonucleotide microarray analysis of distinct gene expression patterns in colorectal cancer tissues harboring BRAF and K-ras mutations.
Colorectal Neoplasms
Oligonucleotide microarray-based mutation detection of the K-ras gene in colorectal cancers with use of competitive DNA hybridization.
Colorectal Neoplasms
Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
Colorectal Neoplasms
Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
Colorectal Neoplasms
Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
Colorectal Neoplasms
Oncogenic K-Ras suppresses IP3-dependent Ca2+ release through remodelling of the isoform composition of IP3Rs and ER luminal Ca2+ levels in colorectal cancer cell lines.
Colorectal Neoplasms
Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells.
Colorectal Neoplasms
Oncogenic Ras mutant causes the hyperactivation of NF-?B via acceleration of its transcriptional activation.
Colorectal Neoplasms
Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.
Colorectal Neoplasms
Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling.
Colorectal Neoplasms
Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Colorectal Neoplasms
Oncosuppressor methylation: A possible key role in colon metastatic progression.
Colorectal Neoplasms
Oncosuppressor methylation: a possible key role in colon metastatic progression.
Colorectal Neoplasms
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Colorectal Neoplasms
Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer.
Colorectal Neoplasms
P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.
Colorectal Neoplasms
p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer.
Colorectal Neoplasms
p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer.
Colorectal Neoplasms
p53 is an independent pre-treatment markers for long-term survival in stage II and III colorectal cancers: an analysis of interaction between genetic markers and fluorouracil-based adjuvant therapy.
Colorectal Neoplasms
P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations.
Colorectal Neoplasms
p53 Overexpression and K-ras Codon 12 Mutations in Submucosal Invasive Colorectal Cancer.
Colorectal Neoplasms
p53 overexpression and K-ras codon 12 mutations in submucosal invasive depressed-type colorectal cancer.
Colorectal Neoplasms
p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis.
Colorectal Neoplasms
Panitumumab and irinotecan every 3 weeks is an active and convenient regimen for second-line treatment of patients with wild-type K-RAS metastatic colorectal cancer.
Colorectal Neoplasms
Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.
Colorectal Neoplasms
Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines.
Colorectal Neoplasms
Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.
Colorectal Neoplasms
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Colorectal Neoplasms
Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Colorectal Neoplasms
Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer.
Colorectal Neoplasms
Persistence of K-ras mutations in plasma after colorectal tumor resection.
Colorectal Neoplasms
Personalized medicine and oncology practice guidelines: a case study of contemporary biomarkers in colorectal cancer.
Colorectal Neoplasms
Phase II study of selumetinib (AZD6244, ARRY-142886) plus irinotecan as second-line therapy in patients with K-RAS mutated colorectal cancer.
Colorectal Neoplasms
Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO.20 Trial.
Colorectal Neoplasms
PIK3CA mutation is predictive of poor survival in patients with colorectal cancer.
Colorectal Neoplasms
PIK3CA, BRAF, and PTEN status and benefit from cetuximab in the treatment of advanced colorectal cancer--results from NCIC CTG/AGITG CO.17.
Colorectal Neoplasms
Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma.
Colorectal Neoplasms
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
Colorectal Neoplasms
Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer.
Colorectal Neoplasms
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Colorectal Neoplasms
Predominance of G to A codon 12 mutation K-ras gene in Dukes' B colorectal cancer.
Colorectal Neoplasms
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Colorectal Neoplasms
Prevalence of G-to-T transversions among K-ras oncogene mutations in human colorectal tumors in Yugoslavia.
Colorectal Neoplasms
Prevalence of p53 overexpression or mutations, but not k-ras mutations, in recurrent patients affected by colorectal-carcinoma.
Colorectal Neoplasms
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Colorectal Neoplasms
Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.
Colorectal Neoplasms
Prognostic impact of K-RAS mutational status and primary tumor location in patients undergoing resection for colorectal cancer liver metastases: an update.
Colorectal Neoplasms
Prognostic impact of K-RAS mutational status and primary tumour location in patients undergoing resection for colorectal cancer liver metastases: A METHEPAR analysis (multicentre study in Argentina).
Colorectal Neoplasms
Prognostic importance of tumor location and anti-EGFR therapy in patients with K-RAS wild type metastatic colorectal cancer.
Colorectal Neoplasms
Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes' B colorectal cancer patients: how much evidence is enough?
Colorectal Neoplasms
Prognostic significance of DNA aneuploidy and p21 ras oncoprotein expression in colorectal cancer and their role in the determination of treatment modalities.
Colorectal Neoplasms
Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
Colorectal Neoplasms
Prognostic significance of K-Ras mutation rate in metastatic colorectal cancer patients.
Colorectal Neoplasms
Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinations.
Colorectal Neoplasms
Prognostic value of K-ras mutations and allelic imbalance on chromosome 18q in patients with resected colorectal cancer.
Colorectal Neoplasms
Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
Colorectal Neoplasms
Prospective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab.
Colorectal Neoplasms
PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients.
Colorectal Neoplasms
Quality of life in patients with K-RAS wild-type colorectal cancer: the CO.20 phase 3 randomized trial.
Colorectal Neoplasms
Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer.
Colorectal Neoplasms
Quantitative detection of mutant alleles of the K-ras gene with minor groove binder-conjugated fluorogenic DNA probes.
Colorectal Neoplasms
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Colorectal Neoplasms
Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma.
Colorectal Neoplasms
Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways.
Colorectal Neoplasms
Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
Colorectal Neoplasms
RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.
Colorectal Neoplasms
Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells.
Colorectal Neoplasms
Rac1B overexpression in Papillary Thyroid Carcinoma: a role to unravel.
Colorectal Neoplasms
Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.
Colorectal Neoplasms
Rapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresis.
Colorectal Neoplasms
Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1? pathway.
Colorectal Neoplasms
Rational Fabrication of a Smart Electrochemiluminescent Sensor: Synergistic Effect of a Self-Luminous Faraday Cage and Biomimetic Magnetic Vesicles.
Colorectal Neoplasms
Re. article entitled 'Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations'.
Colorectal Neoplasms
Recycling Endosomes in Mature Epithelia Restrain Tumorigenic Signaling.
Colorectal Neoplasms
Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents.
Colorectal Neoplasms
Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.
Colorectal Neoplasms
Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation.
Colorectal Neoplasms
Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
Colorectal Neoplasms
Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas.
Colorectal Neoplasms
Relationship Between Expression of ras p21 Oncoprotein and Mutation Status of the K-ras Gene in Sporadic Colorectal Cancer Patients in Tunisia.
Colorectal Neoplasms
Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients.
Colorectal Neoplasms
Relationship of BRAF mutation, morphology, and apoptosis in early colorectal cancer.
Colorectal Neoplasms
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
Colorectal Neoplasms
Reliability of K-ras mutational analysis on cytological samples from metastatic colorectal cancer.
Colorectal Neoplasms
Removal of high-molecular-weight DNA by carboxylated magnetic beads enhances the detection of mutated K-ras DNA in urine.
Colorectal Neoplasms
Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples.
Colorectal Neoplasms
RHOA inactivation enhances Wnt signalling and promotes colorectal cancer.
Colorectal Neoplasms
Role of ?4 integrin in HER-3-negative, K-RAS wild-type metastatic colorectal tumors receiving cetuximab.
Colorectal Neoplasms
Role of retinoids in the prevention and treatment of colorectal cancer.
Colorectal Neoplasms
Sampling technique influences the detection of K-ras mutations in normal appearing mucosa of colorectal cancer patients.
Colorectal Neoplasms
Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver.
Colorectal Neoplasms
Silencing the wild-type and mutant K-ras increases the resistance to 5-flurouracil in HCT-116 as a colorectal cancer cell line.
Colorectal Neoplasms
Simplified rapid non-radioactive PCR-SSCP method applied to K-ras mutation analysis.
Colorectal Neoplasms
Simultaneous mutations in K-ras and TP53 are indicative of poor prognosis in sporadic colorectal cancer.
Colorectal Neoplasms
Small Molecule Destabilizer of ?-Catenin and Ras Proteins Antagonizes Growth of K-Ras Mutation-Driven Colorectal Cancers Resistant to EGFR Inhibitors.
Colorectal Neoplasms
Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA.
Colorectal Neoplasms
Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
Colorectal Neoplasms
Somatic Mutations of K-Ras and BRAF in Thai Colorectal Cancer and their Prognostic Value.
Colorectal Neoplasms
Somatic mutations, acetylator status, and prognosis in colorectal cancer.
Colorectal Neoplasms
Specific c-K-ras gene mutations as a tumor-response marker in locally advanced rectal cancer treated with preoperative chemoradiotherapy.
Colorectal Neoplasms
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Colorectal Neoplasms
Stability of K-ras mutations throughout the natural history of human colorectal cancer.
Colorectal Neoplasms
Statistical strategies to improve the efficiency of molecular studies of colorectal cancer prognosis.
Colorectal Neoplasms
Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA.
Colorectal Neoplasms
Synchronous colorectal cancer: clinical, pathological and molecular implications.
Colorectal Neoplasms
Systemic inflammatory status predict the outcome of k-RAS WT metastatic colorectal cancer patients receiving the thymidylate synthase poly-epitope-peptide anticancer vaccine.
Colorectal Neoplasms
TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status.
Colorectal Neoplasms
Targeted deletion of miR-139-5p activates MAPK, NF-?B and STAT3 signaling and promotes intestinal inflammation and colorectal cancer.
Colorectal Neoplasms
Targeting inhibition of K-ras enhances Ad.mda-7-induced growth suppression and apoptosis in mutant K-ras colorectal cancer cells.
Colorectal Neoplasms
Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.
Colorectal Neoplasms
Tegafur gimeracil oter combined with oxaliplatin for advanced colorectal cancer.
Colorectal Neoplasms
Telomeric repeat-length alterations in colorectal carcinoma are associated with loss of heterozygosity and point mutation in p53 gene.
Colorectal Neoplasms
Tetrac and NDAT Induce Anti-proliferation via Integrin ?v?3 in Colorectal Cancers With Different K-RAS Status.
Colorectal Neoplasms
TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells.
Colorectal Neoplasms
The balanced induction of K-ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues.
Colorectal Neoplasms
The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer.
Colorectal Neoplasms
The combination of tetraiodothyroacetic acid and cetuximab inhibits cell proliferation in colorectal cancers with different K-ras status.
Colorectal Neoplasms
The detection of K-ras mutations in colorectal cancer using the amplification-refractory mutation system.
Colorectal Neoplasms
The differential effects of wildtype and mutated K-Ras on MST2 signalling are determined by K-Ras activation kinetics.
Colorectal Neoplasms
The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
Colorectal Neoplasms
The frequency and spectrum of K-ras mutations among Iraqi patients with sporadic colorectal carcinoma.
Colorectal Neoplasms
The Frequency and Type of K-RAS Mutations in Mexican Patients With Colorectal Cancer: A National Study.
Colorectal Neoplasms
The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer.
Colorectal Neoplasms
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.
Colorectal Neoplasms
The prognostic value of c-Kit, K-ras codon 12, and p53 codon 72 mutations in Egyptian patients with stage II colorectal cancer.
Colorectal Neoplasms
The prognostic value of the presence of mutations at the codons 12, 13, 61 of K-ras oncogene in colorectal cancer.
Colorectal Neoplasms
The role of antiangiogenic agents in the treatment of patients with advanced colorectal cancer according to K-RAS status.
Colorectal Neoplasms
The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab.
Colorectal Neoplasms
The role of K-RAS and B-RAF mutations as biomarkers in metastatic colorectal cancer.
Colorectal Neoplasms
The role of miRNA -31-3p and miR-31-5p in the anti-EGFR treatment efficacy of wild-type K-RAS metastatic colorectal cancer. Is it really the next best thing in miRNAs?
Colorectal Neoplasms
The role of miRNAs targeting K-ras and APC genes in colorectal cancer.
Colorectal Neoplasms
Three-dimensional microarray compared with PCR-single-strand conformation polymorphism analysis/DNA sequencing for mutation analysis of K-ras codons 12 and 13.
Colorectal Neoplasms
Tissue sampling for mutation analysis in colorectal cancer: K-ras is homogeneously distributed throughout the tumor tissue.
Colorectal Neoplasms
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation.
Colorectal Neoplasms
TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells.
Colorectal Neoplasms
Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients.
Colorectal Neoplasms
Tumor location and detection of k-ras mutations in stool from colorectal cancer patients.
Colorectal Neoplasms
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Colorectal Neoplasms
Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling.
Colorectal Neoplasms
Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death.
Colorectal Neoplasms
Understanding the predictive role of K-ras for epidermal growth factor receptor-targeted therapies in colorectal cancer.
Colorectal Neoplasms
Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma.
Colorectal Neoplasms
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Colorectal Neoplasms
Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment.
Colorectal Neoplasms
Use of molecular markers for predicting therapy response in cancer patients.
Colorectal Neoplasms
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Colorectal Neoplasms
Variation in K-ras codon 12 point mutation rate with histological atypia within individual colorectal tumors.
Colorectal Neoplasms
Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers.
Colorectal Neoplasms
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Colorectal Neoplasms
["Field cancerization"--an additional phenomenon in development of colon tumors? K-ras codon 12 mutations in normal colonic mucosa of patients with colorectal neoplasms]
Colorectal Neoplasms
[A Case of Rectal Cancer with Unresectable Liver Metastasis Responding to Rechallenge with FOLFIRI].
Colorectal Neoplasms
[A case of remnant liver metastases after resection of liver metastases from rectal cancer following treatment with 5-FU, L-OHP and CPT-11, with markedly effective treatment by cetuximab plus S-1].
Colorectal Neoplasms
[A study on the mutation of P53 and K-ras gene in colorectal adenomas and colorectal carcinomas].
Colorectal Neoplasms
[Age-related and clinical-pathogenetic features of colorectal cancer associated with status of K-ras gene].
Colorectal Neoplasms
[Analysis of therapeutic effect and prognosis in patients with metastatic colorectal cancer and different K-ras status].
Colorectal Neoplasms
[Association between H-ras and L-myc gene polymorphisms and susceptibility to colorectal cancer].
Colorectal Neoplasms
[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer]
Colorectal Neoplasms
[Cell kinetics of colorectal tumors with assessment by K-ras mutation and PCNA labeling index]
Colorectal Neoplasms
[Clinical outcomes in refractory colorectal cancer patients with wild-type K-ras treated with bevacizumab and oxaliplatin-based chemotherapy as a first-line treatment].
Colorectal Neoplasms
[Clinical relevance of the K-ras oncogene in colorectal cancer: experience in a Mexican population].
Colorectal Neoplasms
[Clinicopathological characteristics, MSI and K-ras gene mutations of double primary malignancies associated with colorectal cancer].
Colorectal Neoplasms
[Correlation analysis between abundance of K-ras mutation in plasma free DNA and its correlation with clinical outcome and prognosis in patients with metastatic colorectal cancer].
Colorectal Neoplasms
[Correlation of K-ras Gene Mutations with the Protein Expressions of TAK1 and MAP4K2 in Colorectal Cancer].
Colorectal Neoplasms
[Detection of genetic mutations in clinical specimens from cancer patients: comparison of NIRCA and SSCP scanning methods]
Colorectal Neoplasms
[Detection of K-ras mutations in colon cancer by PHA-PHFA (preferential homoduplex formation assay)]
Colorectal Neoplasms
[Detection of K-ras point mutations in the stool of patients with colorectal tumors]
Colorectal Neoplasms
[Determination of K-ras gene mutation in colorectal cancer tissue by capillary electrophoresis].
Colorectal Neoplasms
[Effect of microRNA143 expression on cell proliferation in colorectal carcinoma]
Colorectal Neoplasms
[Effect of shRNA-mediated CDC42 knockdown on morphology of colorectal cancer cells in vitro].
Colorectal Neoplasms
[Efficacy and safety of panitumumab for K-ras wild-type unresectable or recurrent colorectal cancer - a study focusing on first-line treatment].
Colorectal Neoplasms
[Efficacy of cetuximab combined with chemotherapy for patients with advanced colorectal cancer and unclear K-ras status].
Colorectal Neoplasms
[Frequency and clinicopathological associations of K-ras mutations in Venezuelan patients with colo-rectal cancer]
Colorectal Neoplasms
[Identification of K-RAS mutations in colorectal cancer patients in Israel].
Colorectal Neoplasms
[Immunohistological study for the ras oncogene products in colorectal cancer]
Colorectal Neoplasms
[K-ras gene mutation in colorectal cancer and its clinicopathologic significance].
Colorectal Neoplasms
[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
Colorectal Neoplasms
[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
Colorectal Neoplasms
[Mutations of APC and K-ras gene in aberrant crypt foci from human colon]
Colorectal Neoplasms
[Outcomes of patients with small bowel carcinoma treated with appropriate chemotherapy selected on the basis of genetic analysis findings].
Colorectal Neoplasms
[Pharmacoeconomics of molecular target drug: K-ras testing and cetuximab for colorectal cancer as an example].
Colorectal Neoplasms
[Prognostic value of the presence of the mutation of the codons 12, 13 and 61 in K-ras oncogene in colorectal cancer]
Colorectal Neoplasms
[Sensitive detection of K-ras oncogene codon 12 mutations by nested PCR using mismatched primers and selective digestion of non-mutated PCR fragments with restriction enzyme]
Colorectal Neoplasms
[Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene]
Colorectal Neoplasms
[Study on relationship of the K-ras mutation with the occurrence of colorectal liver metastasis and survival outcomes].
Colorectal Neoplasms
[The Aragonese mummies of the Basilica of Saint Domenico Maggiore in Naples]
Colorectal Neoplasms
[Two cases of metastatic colorectal cancer in wild-type K-RAS effectively treated by panitumumab].
Colorectal Neoplasms
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Colorectal Neoplasms, Hereditary Nonpolyposis
Hyperprogressive Disease in an Advanced Stage Colon Cancer Patient on Pembrolizumab: A Case Report.
Colorectal Neoplasms, Hereditary Nonpolyposis
No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
Colorectal Neoplasms, Hereditary Nonpolyposis
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Communicable Diseases
Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?
Cone-Rod Dystrophies
Mutations in RAB28, encoding a farnesylated small GTPase, are associated with autosomal-recessive cone-rod dystrophy.
Cone-Rod Dystrophies
Whole-Organism Developmental Expression Profiling Identifies RAB-28 as a Novel Ciliary GTPase Associated with the BBSome and Intraflagellar Transport.
Confusion
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Congenital Abnormalities
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
Congenital Abnormalities
Inactivation of Cdc42 in neural crest cells causes craniofacial and cardiovascular morphogenesis defects.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Germline expression of H-Ras causes neurological deficits associated to Costello syndrome.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model.
Coronary Artery Disease
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Coronary Artery Disease
Gene-smoking interactions in multiple Rho-GTPase pathway genes in an early-onset coronary artery disease cohort.
Coronary Artery Disease
Potentially critical roles of TNPO1, RAP1B, ZDHHC17, and PPM1B in the progression of coronary atherosclerosis through microarray data analysis.
Costello Syndrome
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.
Costello Syndrome
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
Costello Syndrome
Germline expression of H-Ras causes neurological deficits associated to Costello syndrome.
Costello Syndrome
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Costello Syndrome
RasGRF1 regulates proliferation and metastatic behavior of human alveolar rhabdomyosarcomas.
Costello Syndrome
Retinoblastoma protein modulates the inverse relationship between cellular proliferation and elastogenesis.
Costello Syndrome
The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model.
COVID-19
Differential Expression of Rab5 and Rab7 Small GTPase Proteins in Placental Tissues From Pregnancies Affected by Maternal Coronavirus Disease 2019.
COVID-19
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells.
Craniosynostoses
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay.
Craniosynostoses
Clinical study and some molecular features of Mexican patients with syndromic craniosynostosis.
Craniosynostoses
Genetics of craniosynostosis: genes, syndromes, mutations and genotype-phenotype correlations.
Craniosynostoses
Molecular Analysis of Gli3, Ihh, Rab23, and Jag1 in a Rabbit Model of Craniosynostosis: Likely Exclusion as the Loci of Origin.
Craniosynostoses
Mutation Screening of Candidate Genes in Patients with Nonsyndromic Sagittal Craniosynostosis.
Craniosynostoses
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.
Creutzfeldt-Jakob Syndrome
Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt-Jakob disease.
Creutzfeldt-Jakob Syndrome
Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: impact on Rab3a recycling.
Crohn Disease
A genome-wide association study identifying RAP1A as a novel susceptibility gene for Crohn's disease in Japanese individuals.
Crohn Disease
Activating mutations in the k-ras gene in ulcerative-colitis and crohns-disease.
Crohn Disease
Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease.
Crohn Disease
MicroRNA-15a - cell division cycle 42 signaling pathway in pathogenesis of pediatric inflammatory bowel disease.
Crohn Disease
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Crohn Disease
Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease.
Crohn Disease
TLR sorting by Rab11 endosomes maintains intestinal epithelial-microbial homeostasis.
Cryptococcosis
Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions.
Cryptosporidiosis
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Cystadenocarcinoma
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
Cystadenocarcinoma
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Cystadenocarcinoma
K-ras oncogene mutations indicate malignancy in cystic tumors of the pancreas.
Cystadenocarcinoma, Mucinous
Appendiceal mucinous cystadenocarcinoma with mural nodules of anaplastic carcinoma and K-RAS mutation.
Cystadenocarcinoma, Serous
Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.
Cystadenoma
Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
Cystadenoma
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
Cystadenoma
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
Cystadenoma, Mucinous
Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
Cystic Adenomatoid Malformation of Lung, Congenital
Mucinous bronchioloalveolar carcinoma with K-ras mutation arising in type 1 congenital cystic adenomatoid malformation: a case report with review of the literature.
Cystic Fibrosis
A neutrophil intrinsic impairment affecting Rab27a and degranulation in cystic fibrosis is corrected by CFTR potentiator therapy.
Cystic Fibrosis
Burkholderia cenocepacia infection: Disruption of phagocyte immune functions through Rho GTPase inactivation.
Cystic Fibrosis
Cl- channels regulate lipid droplet formation via Rab8a expression during adipocyte differentiation.
Cystic Fibrosis
Elevated small GTPase activation influences the cell proliferation signaling control in Niemann-Pick type C fibroblasts.
Cystic Fibrosis
Rab27a negatively regulates CFTR chloride channel function in colonic epithelia: involvement of the effector proteins in the regulatory mechanism.
Cystic Fibrosis
Regulation of cystic fibrosis transmembrane regulator trafficking and protein expression by a Rho family small GTPase TC10.
Cystic Fibrosis
Soluble normal and mutated DNA sequences from single-copy genes in human blood.
Cystinosis
Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Cystitis
H-ras immunohistochemical expression and molecular analysis of urinary bladder lesions in grazing adult cattle exposed to bracken fern.
Cystitis
Survey of ferns and clinico-pathological studies on the field cases of Enzootic bovine haematuria in Himachal Pradesh, a north-western Himalayan state of India.
Cysts
Activated ras protein accelerates cell cycle progression to perturb madin-darby canine kidney cystogenesis.
Cysts
Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro.
Cysts
Active Rab11 and functional recycling endosome are required for E-cadherin trafficking and lumen formation during epithelial morphogenesis.
Cysts
Apical polarity proteins recruit the RhoGEF Cysts to promote junctional myosin assembly.
Cysts
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis.
Cysts
CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane.
Cysts
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis.
Cysts
Comparison of carcinoembryonic antigen and molecular analysis in pancreatic cyst fluid.
Cysts
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Cysts
H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel.
Cysts
K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas.
Cysts
K-ras Mutations Correlate with Atypical Cytology and Elevated CEA Levels in Pancreatic Cystic Neoplasms.
Cysts
K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.
Cysts
K-RAS mutations in ovarian and extraovarian lesions of serous tumors of borderline malignancy.
Cysts
Molecular analysis of pancreatic cyst fluid: a comparative analysis with current practice of diagnosis.
Cysts
Morphogenetic and Molecular Analyses of Cyst Wall Components in the Ciliated Protozoan Colpoda cucullus Nag-1.
Cysts
Pak1 regulates the orientation of apical polarization and lumen formation by distinct pathways.
Cysts
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study.
Cysts
Par6B and Atypical PKC Regulate Mitotic Spindle Orientation during Epithelial Morphogenesis.
Cysts
Proliferative signaling by ERBB proteins and RAF/MEK/ERK effectors in polycystic kidney disease.
Cysts
Rab11 and actin cytoskeleton participate in Giardia lamblia encystation, guiding the specific vesicles to the cyst wall.
Cysts
Rab35 GTPase couples cell division with initiation of epithelial apico-basal polarity and lumen opening.
Cysts
Rac1 orientates epithelial apical polarity through effects on basolateral laminin assembly.
Cysts
RBD11, a bioengineered Rab11-binding module for visualizing and analyzing endogenous Rab11.
Cysts
Regulation of podocalyxin trafficking by Rab small GTPases in 2D and 3D epithelial cell cultures.
Cysts
Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.
Cysts
The effect of trehalose on autophagy-related proteins and cyst growth in a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease.
Cysts
The Rho family of small GTPases is involved in epithelial cystogenesis and tubulogenesis.
Cysts
Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation.
Cysts
Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.
Cytomegalovirus Infections
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
Cytomegalovirus Infections
Drebrin E depletion in human intestinal epithelial cells mimics Rab8a loss of function.
Cytomegalovirus Infections
Myosin Vb uncoupling from RAB8A and RAB11A elicits microvillus inclusion disease.
Cytomegalovirus Infections
Rab11 Is a Useful Tool for the Diagnosis of Microvillous Inclusion Disease.
Deafness
DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.
Deafness
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Deafness
Pleiotropic effects of coat colour-associated mutations in humans, mice and other mammals.
Dehydration
Cloning and characterization of a salt stress-inducible small GTPase gene from the model grass species Lolium temulentum.
Dehydration
Microbes in Cahoots with Plants: MIST to Hit the Jackpot of Agricultural Productivity during Drought.
Dehydration
Overexpression of a PLDalpha1 gene from Setaria italica enhances the sensitivity of Arabidopsis to abscisic acid and improves its drought tolerance.
Dehydration
Overexpression of a wheat phospholipase D gene, TaPLD?, enhances tolerance to drought and osmotic stress in Arabidopsis thaliana.
Dehydration
The expression of a rab-related gene, rab18, is induced by abscisic acid during the cold acclimation process of Arabidopsis thaliana (L.) Heynh.
Dehydration
The soybean U-box gene GmPUB6 regulates drought tolerance in Arabidopsis thaliana.
Dementia
Growth-associated protein GAP-43 in the frontal cortex and in the hippocampus in Alzheimer's disease: an immunohistochemical and quantitative study.
Dementia
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Dementia
Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele.
Dementia
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.
Dementia
Xanthoceras sorbifolia extracts ameliorate dendritic spine deficiency and cognitive decline via upregulation of BDNF expression in a rat model of Alzheimer's disease.
Demyelinating Diseases
Peripheral nerve demyelination caused by a mutant Rho GTPase guanine nucleotide exchange factor, frabin/FGD4.
Dengue
Disentangling the role of PI3K/Akt, Rho GTPase and the actin cytoskeleton on dengue virus infection.
Dengue
Effect of the Rho GTPase inhibitor-1 on the entry of dengue serotype 2 virus into EAhy926 cells.
Dengue
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Dengue
Insight into structural organization and protein-protein interaction of non structural 3 (NS3) proteins from dengue serotypes.
Dengue
Molecular dissection of dengue virus egress: involvement of the class II ARF small GTPase.
Dengue
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Dengue
Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Dengue
Rac1 and Cdc42 GTPases cross-talk regulates formation of filopodia required for Dengue virus type-2 entry into HMEC-1 cells.
Dengue
Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.
Dengue
The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure.
Dental Pulp Calcification
Cell shape and epithelial patterning in the Drosophila embryonic epidermis.
Dermatitis, Phototoxic
Phototoxic effects of lysosome-associated genetically encoded photosensitizer KillerRed.
Diabetes Mellitus
IFN-?/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
Diabetes Mellitus
Multicenter analysis of risk factors for anastomotic leakage after middle and low rectal cancer resection without diverting stoma: a retrospective study of 319 consecutive patients.
Diabetes Mellitus
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Diabetes Mellitus
[Changes in functional state of the low-molecular G-proteins of platelets in type 1 diabetes mellitus]
Diabetes Mellitus, Type 1
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction].
Diabetes Mellitus, Type 1
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo.
Diabetes Mellitus, Type 1
[Changes in functional state of the low-molecular G-proteins of platelets in type 1 diabetes mellitus]
Diabetes Mellitus, Type 2
Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects.
Diabetes Mellitus, Type 2
GGPPS-mediated Rab27A geranylgeranylation regulates ? cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation.
Diabetes Mellitus, Type 2
Measuring gene-gene interaction using Kullback-Leibler divergence.
Diabetes Mellitus, Type 2
Multi-step pancreatic carcinogenesis and its clinical implications.
Diabetes Mellitus, Type 2
Rac1-NADPH oxidase signaling promotes CD36 activation under glucotoxic conditions in pancreatic beta cells.
Diabetes, Gestational
Down-regulation of microRNA-30d-5p is associated with gestational diabetes mellitus by targeting RAB8A.
Diabetic Cardiomyopathies
miR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy.
Diabetic Nephropathies
Gender Differences in Genetic Associations of RAB38 with Urinary Protein-to-Creatinine Ratio (UPCR) Levels in Diabetic Nephropathy Patients.
Diabetic Nephropathies
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Diabetic Nephropathies
Identification of up-regulated Ras-like GTPase, Rap1b, by suppression subtractive hybridization.
Diabetic Nephropathies
Inhibiting Rab27a in renal tubular epithelial cells attenuates the inflammation of diabetic kidney disease through the miR-26a-5p/CHAC1/NF-kB pathway.
Diabetic Nephropathies
Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice.
Diabetic Nephropathies
Protective effects of calcitriol on diabetic nephropathy are mediated by down regulation of TGF-?1 and CIP4 in diabetic nephropathy rat.
Diabetic Nephropathies
Ras-Related C3 Botulinum Toxin Substrate 1 Combining With the Mixed Lineage Kinase 3- Mitogen-Activated Protein Kinase 7- c-Jun N-Terminal Kinase Signaling Module Accelerates Diabetic Nephropathy.
Diabetic Nephropathies
Rho-kinase inhibition prevents the progression of diabetic nephropathy by downregulating hypoxia-inducible factor 1?.
Diabetic Nephropathies
ROCK2 regulates TGF-?-induced expression of CTGF and profibrotic genes via NF-?B and cytoskeleton dynamics in mesangial cells.
Diabetic Retinopathy
cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association.
Diabetic Retinopathy
Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy.
Diabetic Retinopathy
Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9.
Diabetic Retinopathy
Ras-related C3 botulinum toxin substrate 1 activation is involved in the pathogenesis of diabetic retinopathy.
Diabetic Retinopathy
Role of Matrix Metalloproteinase-9 in the Development of Diabetic Retinopathy and its Regulation by H-Ras.
Diabetic Retinopathy
Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy.
Diabetic Retinopathy
Small molecular weight G-protein, H-Ras, and retinal endothelial cell apoptosis in diabetes.
Diabetic Retinopathy
Translocation of H-Ras and its implications in the development of diabetic retinopathy.
DiGeorge Syndrome
Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome.
dihydropyrimidinase deficiency
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Dihydropyrimidine Dehydrogenase Deficiency
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Diphtheria
An Entamoeba histolytica ADP-ribosyl transferase from the diphtheria toxin family modifies the bacterial elongation factor Tu.
Diphtheria
Escherichia coli cytotoxic necrotizing factor 1: evidence for induction of actin assembly by constitutive activation of the p21 Rho GTPase.
Disorders of Sex Development
Sex differences in autophagy-mediated diseases: toward precision medicine.
Diverticulitis
Expression of protooncogene-encoded mRNA by colonic epithelial cells in inflammatory bowel disease.
Down Syndrome
Detection of UV-induced K-ras codon 12 mutation by PCR and differential dot-blot hybridization in cells from Down syndrome and Cockayne syndrome.
Drug Resistant Epilepsy
[Overexpression of the Cdc42 in the brain tissue of human with intractable temporal epilepsy]
Dyskinesias
Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesia.
Dyslexia
Two Autism/Dyslexia Linked Variations of DOCK4 Disrupt the Gene Function on Rac1/Rap1 Activation, Neurite Outgrowth, and Synapse Development.
Encephalitis, Japanese
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells.
Encephalocele
Novel mouse model of encephalocele: post-neurulation origin and relationship to open neural tube defects.
Encephalomyelitis
miR-142a-3p promotes the proliferation of porcine hemagglutinating encephalomyelitis virus by targeting Rab3a.
Encephalomyelitis
You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
You-Gui pills promote nerve regeneration by regulating netrin1, DCC and Rho family GTPases RhoA, Racl, Cdc42 in C57BL/6 mice with experimental autoimmune encephalomyelitis.
Endometrial Hyperplasia
Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium.
Endometrial Hyperplasia
Clonal analysis and mutations in the PTEN and the K-ras genes in endometrial hyperplasia.
Endometrial Hyperplasia
K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
Endometrial Hyperplasia
K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
Endometrial Hyperplasia
K-ras mutations in endometrial carcinomas with microsatellite instability.
Endometrial Hyperplasia
Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification.
Endometrial Hyperplasia
New concepts in the diagnosis and prognosis of endometrial carcinoma.
Endometrial Hyperplasia
Surgical treatment of high stage endometrial cancer: current perspectives.
Endometrial Neoplasms
Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma.
Endometrial Neoplasms
Alteration of the k-ras gene expression in atypical and nonatypical hyperplastic endometrium.
Endometrial Neoplasms
Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado.
Endometrial Neoplasms
Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma.
Endometrial Neoplasms
Analysis of point mutations at codon 12 of K-ras in human endometrial carcinoma and cervical adenocarcinoma by dot blot hybridization and polymerase chain reaction.
Endometrial Neoplasms
Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy.
Endometrial Neoplasms
Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.
Endometrial Neoplasms
Chromosomal deletions and K-ras gene mutations in human endometrial carcinomas.
Endometrial Neoplasms
Chromosome aberrations [dup(1q)] in endometrial cancer: Gene analysis of 54 surgical specimens in Turkey.
Endometrial Neoplasms
Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.
Endometrial Neoplasms
Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.
Endometrial Neoplasms
Detection of clonality and genetic alterations in endometrial pipelle biopsy and its surgical specimen counterpart.
Endometrial Neoplasms
Detection of human papillomavirus types 16 and 18 in human neoplastic endometrium: lack of correlation with established prognostic factors.
Endometrial Neoplasms
Detection of K-ras mutations in cancerous lesions of human endometrium.
Endometrial Neoplasms
Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous morules).
Endometrial Neoplasms
Endometrial cancer side-population cells show prominent migration and have a potential to differentiate into the mesenchymal cell lineage.
Endometrial Neoplasms
Endometrial carcinomas with significant mucinous differentiation associated with higher frequency of k-ras mutations: a morphologic and molecular correlation study.
Endometrial Neoplasms
Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability.
Endometrial Neoplasms
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
Endometrial Neoplasms
Genetic Alterations in SMAD4 and K-ras in Serbian Patients With Endometrial Carcinoma.
Endometrial Neoplasms
Genotype-dependent efficacy of a dual PI3K/mTOR inhibitor, NVP-BEZ235, and an mTOR inhibitor, RAD001, in endometrial carcinomas.
Endometrial Neoplasms
Geraniol Inhibits Endometrial Carcinoma via Downregulating Oncogenes and Upregulating Tumour Suppressor Genes.
Endometrial Neoplasms
Immunohistochemical analysis of MIB-1 proliferative activity in human endometrial cancer. Correlation with clinicopathological parameters, patient outcome, retinoblastoma immunoreactivity and K-ras codon 12 point mutations.
Endometrial Neoplasms
K-ras gene point mutations in human endometrial carcinomas: correlation with clinicopathological features and patients' outcome.
Endometrial Neoplasms
K-ras mutations in endometrial carcinomas with microsatellite instability.
Endometrial Neoplasms
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
Endometrial Neoplasms
K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
Endometrial Neoplasms
K-Ras stabilization by estrogen via PKC? is involved in endometrial tumorigenesis.
Endometrial Neoplasms
LncRNA LOXL1-AS1 promotes endometrial cancer progression by sponging miR-28-5p to upregulate RAP1B expression.
Endometrial Neoplasms
MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases.
Endometrial Neoplasms
Microsatellite instability and somatic mutations in endometrial carcinomas.
Endometrial Neoplasms
Model for the molecular genetic diagnosis of endometrial cancer using K-ras mutation analysis.
Endometrial Neoplasms
Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis.
Endometrial Neoplasms
Molecular differences between RER+ and RER- sporadic endometrial carcinomas in a large population-based series.
Endometrial Neoplasms
Molecular genetic characterization of tamoxifen-associated endometrial cancer.
Endometrial Neoplasms
Molecular pathology of endometrial carcinoma: transcriptional signature in endometrioid tumors.
Endometrial Neoplasms
Monitoring of endometrial K-ras mutation in tamoxifen-treated patients with breast cancer.
Endometrial Neoplasms
Novel molecular profiles of endometrial cancer-new light through old windows.
Endometrial Neoplasms
Oncogenic Ras modulates epidermal growth factor responsiveness in endometrial carcinomas.
Endometrial Neoplasms
Phase I, Open-Label, Dose-Escalation/Dose-Expansion Study of Lifirafenib (BGB-283), an RAF Family Kinase Inhibitor, in Patients With Solid Tumors.
Endometrial Neoplasms
PIK3CA gene mutations in endometrial carcinoma: correlation with PTEN and K-RAS alterations.
Endometrial Neoplasms
Predicting everolimus treatment efficacy in patients with advanced endometrial carcinoma: a GINECO group study.
Endometrial Neoplasms
Promoter hypermethylation and expression of sprouty 2 in endometrial carcinoma.
Endometrial Neoplasms
Promoter hypermethylation and reduced expression of RASSF1A are frequent molecular alterations of endometrial carcinoma.
Endometrial Neoplasms
RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer.
Endometrial Neoplasms
RB protein expression in human endometrial carcinomas--an immunohistochemical study.
Endometrial Neoplasms
Surgical treatment of high stage endometrial cancer: current perspectives.
Endometrial Neoplasms
The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer.
Endometrial Neoplasms
The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells.
Endometrial Neoplasms
The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action.
Endometrial Neoplasms
Tumorigenesis of K-ras mutation in human endometrial carcinoma via upregulation of estrogen receptor.
Endometrial Neoplasms
[Targeting Ras-PI3K/mTOR pathway and the predictive biomarkers in endometrial cancer].
Endometrial Neoplasms
[The factors involved in invasive ability of endometrial carcinoma cells]
Endometriosis
Activation of mutated K-ras in donor endometrial epithelium and stroma promotes lesion growth in an intact immunocompetent murine model of endometriosis.
Endometriosis
CDC42-positive macrophages may prevent malignant transformation of ovarian endometriosis.
Endometriosis
Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339.
Endometriosis
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Endometriosis
Fine mapping of variants associated with endometriosis in the WNT4 region on chromosome 1p36.
Endometriosis
K-Ras 4A Transcript variant is up-regulated in eutopic endometrium of endometriosis patients during proliferative phase of menstrual cycle.
Endometriosis
K-ras mutation may promote carcinogenesis of endometriosis leading to ovarian clear cell carcinoma.
Endometriosis
Malignant transformation of endometriosis and genetic alterations of K-ras and microsatellite instability.
Endometriosis
Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis.
Endometriosis
Novel ovarian endometriosis model causes infertility via iron-mediated oxidative stress in mice.
Endometriosis
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Endotoxemia
Hepatic Rac1 GTPase contributes to liver-mediated basal immune homeostasis and LPS-induced endotoxemia.
Endotoxemia
Increased survival and reduced neutrophil infiltration of the liver in rab27a- but not munc13-4-deficient mice in lipopolysaccharide-induced systemic inflammation.
Enteritis
1,25-Dihydroxyvitamin D3 and dietary vitamin D reduce inflammation in mice lacking intestinal epithelial cell Rab11a.
Enteritis
Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens.
Eosinophilia
A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer.
Eosinophilia
Differential expression and activation of Rab27A in human eosinophils: relationship to blood eosinophilia.
Epidermal Cyst
The radiosensitivity of human keratinocytes: influence of activated c-H-ras oncogene expression and tumorigenicity.
Epilepsy
Aurora A plays a dual role in migration and survival of human glioblastoma cells according to the CXCL12 concentration.
Epilepsy
Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
Epilepsy
[Overexpression of the Cdc42 in the brain tissue of human with intractable temporal epilepsy]
Epilepsy, Temporal Lobe
Inhibition of the small GTPase Cdc42 in regulation of epileptic-seizure in rats.
Epstein-Barr Virus Infections
Molecular characterization of primary mediastinal B cell lymphoma.
Epstein-Barr Virus Infections
Possible association of active gastritis, featuring accelerated cell turnover and p53 overexpression, with cancer development at anastomoses after gastrojejunostomy. Comparison with gastroduodenostomy.
Esophageal Neoplasms
Assessment of epidermal growth factor receptor mutation/copy number and K-ras mutation in esophageal cancer.
Esophageal Neoplasms
Characterization and effects of miR-21 expression in esophageal cancer.
Esophageal Neoplasms
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Esophageal Neoplasms
Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells.
Esophageal Neoplasms
K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma.
Esophageal Neoplasms
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
Esophageal Neoplasms
Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.
Esophageal Neoplasms
Relationship between H-ras p21 product and p53 protein or high-risk human papillomaviruses in esophageal cancer from Kochi, Japan.
Esophageal Neoplasms
RNAi-induced K-Ras Gene Silencing Suppresses Growth of EC9706 Cells and Enhances Chemotherapy Sensitivity of Esophageal Cancer.
Esophageal Neoplasms
Suppression of Erk activation and in vivo growth in esophageal cancer cells by the dominant negative Ras mutant, N116Y.
Esophageal Neoplasms
The expression of H-ras p21 product in esophageal cancer from Hong Kong Chinese.
Esophageal Neoplasms
TNK2 promoted esophageal cancer progression via activating egfr-akt signaling.
Esophageal Squamous Cell Carcinoma
An association study on genetic polymorphisms of Rab37 gene with the risk of esophageal squamous cell carcinoma in a Chinese Han population.
Esophageal Squamous Cell Carcinoma
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Esophageal Squamous Cell Carcinoma
Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42.
Esophageal Squamous Cell Carcinoma
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Esophageal Squamous Cell Carcinoma
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Esophageal Squamous Cell Carcinoma
microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
MicroRNA-429 inhibits the proliferation and migration of esophageal squamous cell carcinoma cells by targeting RAB23 through the NF-?B pathway.
Esophageal Squamous Cell Carcinoma
miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42.
Esophageal Squamous Cell Carcinoma
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
Esophageal Squamous Cell Carcinoma
miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Esophageal Squamous Cell Carcinoma
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
The Rho GTPase RhoE exerts tumor-suppressing effects in human esophageal squamous cell carcinoma via negatively regulating epidermal growth factor receptor.
Exanthema
Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer.
Exanthema
Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21.
Exanthema
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
Exanthema
Ral-GTPases mediate a distinct downstream signaling pathway from Ras that facilitates cellular transformation.
Exocrine Pancreatic Insufficiency
Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.
Fanconi Anemia
Defective homing is associated with altered Cdc42 activity in cells from patients with Fanconi anemia group A.
Fasciculation
p190 RhoGAP is the principal Src substrate in brain and regulates axon outgrowth, guidance and fasciculation.
Fasciculation
The small GTPase Rac is involved in clustering of hippocampal neurons and fasciculation of their neurites.
Fatty Liver
Integrated Analysis and Identification of Novel Biomarkers in Parkinson's Disease.
Fetal Alcohol Spectrum Disorders
Ethanol impairs Rho GTPase signaling and differentiation of cerebellar granule neurons in a rodent model of fetal alcohol syndrome.
Fetal Growth Retardation
Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction.
Fibrosarcoma
70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity.
Fibrosarcoma
A calcium binding protein, S100A4, mediates T cell dependent cytotoxicity as a transformation-associated antigen.
Fibrosarcoma
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
Fibrosarcoma
A PSP94-derived peptide PCK3145 inhibits MMP-9 secretion and triggers CD44 cell surface shedding: implication in tumor metastasis.
Fibrosarcoma
Activation of K-ras and oncogenes other than ras family in rat fibrosarcomas induced by 1,8-dinitropyrene.
Fibrosarcoma
Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
Fibrosarcoma
Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.
Fibrosarcoma
Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells.
Fibrosarcoma
Involvement of peptide antigens in the cytotoxicity between 70-kDa heat shock cognate protein-like molecule and CD3+, CD4-, CD8-, TCR-alpha beta- killer T cells.
Fibrosarcoma
Molecular cloning of rat NK target structure--the possibility of CD44 involvement in NK cell-mediated lysis.
Fibrosarcoma
S-Adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
Fibrosarcoma
S-adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
Fibrosarcoma
The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration.
Fibrosarcoma
Tissue factor pathway inhibitor-2 suppresses the production of active matrix metalloproteinase-2 and is down-regulated in cells harboring activated ras oncogenes.
Fibrosarcoma
Transforming growth factor beta 1 selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed fibrosarcoma cell lines.
Fibrosarcoma
Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function.
Foot-and-Mouth Disease
Foot-and-mouth disease virus degrades Rab27a to suppress the exosome-mediated antiviral immune response.
Foot-and-Mouth Disease
G3BP1 interacts directly with the FMDV IRES and negatively regulates translation.
Fragile X Syndrome
The small GTPase Arf6 is dysregulated in a mouse model for fragile X syndrome.
Frontotemporal Lobar Degeneration
Altered Expression of Circulating Cdc42 in Frontotemporal Lobar Degeneration.
Galactosemias
Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy.
Gallbladder Neoplasms
A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model.
Gallbladder Neoplasms
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Gallbladder Neoplasms
Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer.
Gallbladder Neoplasms
Epithelial cell proliferation and gene mutation in the mucosa of gallbladder with pancreaticobiliary malunion and cancer.
Gallbladder Neoplasms
High frequency of TP53 but not K-ras gene mutations in Bolivian patients with gallbladder cancer.
Gallbladder Neoplasms
K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
Gallbladder Neoplasms
K-ras oncogene mutation in cancer and precancerous lesions of the gallbladder.
Gallbladder Neoplasms
K-ras, p53 mutations, and microsatellite instability (MSI) in gallbladder cancer.
Gallbladder Neoplasms
Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
Gallbladder Neoplasms
p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
Gallbladder Neoplasms
Prognostic Significance of K- ras Codon 12 Mutation in Patients with Resected Gallbladder Cancer.
Gallbladder Neoplasms
Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis.
Gallbladder Neoplasms
Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction.
Gallbladder Neoplasms
Sporadic TP53 transition mutations in chronic cholecystitis are possibly linked to gallbladder carcinogenesis.
Gallbladder Neoplasms
Tumor Protein p53 and K-ras Gene Mutations in Peruvian Patients with Gallbladder Cancer
Gallbladder Neoplasms
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Ganglioneuroblastoma
Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.
Gastritis
Braf, Kras and Helicobacter pylori epigenetic changes-associated chronic gastritis in Egyptian patients with and without gastric cancer.
Gastritis
K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
Gastritis
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
Gastritis
[Study on association between an H-RAS gene polymorphism and gastric cancer development]
Gastritis, Atrophic
[Gene expression profiling using oligonucleotide microarray in atrophic gastritis and intestinal metaplasia]
Gastritis, Atrophic
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Gastroenteritis
A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis.
Gastrointestinal Diseases
Molecular detection of codon 12 K-RAS mutations in circulating DNA from serum of colorectal cancer patients.
Gastrointestinal Neoplasms
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
Gastrointestinal Neoplasms
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Gastrointestinal Neoplasms
Clinical update on K-Ras targeted therapy in gastrointestinal cancers.
Gastrointestinal Neoplasms
Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.
Gastrointestinal Neoplasms
Molecular markers predictive of response to chemotherapy in gastrointestinal tumors.
Gastrointestinal Neoplasms
Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults.
Gastrointestinal Neoplasms
The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
Gastrointestinal Neoplasms
The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status.
Gastrointestinal Stromal Tumors
Prognostic value of Rab27B nuclear expression in gastrointestinal stromal tumors.
Genetic Diseases, Inborn
A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.
Genetic Diseases, Inborn
Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
Genetic Diseases, Inborn
Molecular inversion probes equipped with discontinuous rolling cycle amplification for targeting nucleotide variants: Determining SMN1 and SMN2 genes in diagnosis of spinal muscular atrophy.
Genetic Diseases, Inborn
Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.
Giant Cell Tumor of Bone
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
Giant Cell Tumor of Bone
STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.
Giant Cell Tumors
Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
Giant Cell Tumors
K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
Giant Cell Tumors
Origin of giant cells in osteoclast-like giant cell tumors of the pancreas.
Giant Cell Tumors
STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.
Gingival Overgrowth
Lack of mutation in p53 and H-ras genes in phenytoin induced gingival overgrowth suggests its non cancerous nature.
Glaucoma
Chemo-informatics guided study of natural inhibitors targeting rho GTPase: a lead for treatment of glaucoma.
Glaucoma
Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork.
Glaucoma, Open-Angle
Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork.
Glioblastoma
?v?8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion.
Glioblastoma
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.
Glioblastoma
Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.
Glioblastoma
Active ras triggers death in glioblastoma cells through hyperstimulation of macropinocytosis.
Glioblastoma
AEG-1 promotes mesenchymal transition through the activation of Rho GTPases in human glioblastoma cells.
Glioblastoma
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
Glioblastoma
Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.
Glioblastoma
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Glioblastoma
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Glioblastoma
In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion.
Glioblastoma
Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation--impact of Ras-/Rho-prenylation.
Glioblastoma
Luteolin inhibits migration of human glioblastoma U-87 MG and T98G cells through downregulation of Cdc42 expression and PI3K/AKT activity.
Glioblastoma
miR-181 subunits enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeleton remodeling in glioblastoma cells.
Glioblastoma
miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.
Glioblastoma
Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.
Glioblastoma
RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
Glioblastoma
RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.
Glioblastoma
Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.
Glioblastoma
RND2 attenuates apoptosis and autophagy in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Glioblastoma
RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion.
Glioblastoma
Small G protein Rac GTPases regulate the maintenance of glioblastoma stem-like cells in vitro and in vivo.
Glioblastoma
Small GTPase RHOE/RND3, a new critical regulator of NF-?B signalling in glioblastoma multiforme?
Glioblastoma
SPARC-induced migration of glioblastoma cell lines via uPA-uPAR signaling and activation of small GTPase RhoA.
Glioblastoma
Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma.
Glioblastoma
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.
Glioblastoma
Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastoma.
Glioma
A software application for comparing large numbers of high resolution MALDI-FTICR MS spectra demonstrated by searching candidate biomarkers for glioma blood vessel formation.
Glioma
ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway.
Glioma
Alphavbeta3 and alphavbeta5 integrins control glioma cell response to ionising radiation through ILK and RhoB.
Glioma
An imbalance between Smad and MAPK pathways is responsible for TGF-beta tumor promoting effects in high-grade gliomas.
Glioma
Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells.
Glioma
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
Glioma
CircRNA hsa_circ_0030018 regulates the development of glioma via regulating the miR-1297/RAB21 axis.
Glioma
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Glioma
Decreased expression of miR-410-3p correlates with poor prognosis and tumorigenesis in human glioma.
Glioma
Downregulation of ARHGDIA contributes to human glioma progression through activation of Rho GTPase signaling pathway.
Glioma
Effect of Ras-guanine nucleotide release factor 1-mediated H-Ras/ERK signaling pathway on glioma.
Glioma
Effects of Rab27a on proliferation, invasion, and anti-apoptosis in human glioma cell.
Glioma
EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth.
Glioma
Enhanced glioma-targeting and stability of LGICP peptide coupled with stabilized peptide DA7R.
Glioma
Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice.
Glioma
Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma.
Glioma
Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice.
Glioma
GFAP-Cre-Mediated Activation of Oncogenic K-ras Results in Expansion of the Subventricular Zone and Infiltrating Glioma.
Glioma
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Glioma
Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion.
Glioma
Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
Glioma
Illuminating Radiogenomic Characteristics of Glioblastoma Multiforme through Integration of MR Imaging, Messenger RNA Expression, and DNA Copy Number Variation.
Glioma
In contrast to EGFr gene overexpression, H-ras gene expression decreases in human gliomas.
Glioma
Inhibition of Rho pathways induces radiosensitization and oxygenation in human glioblastoma xenografts.
Glioma
Insulin-like growth factor binding protein 2 promotes glioma development and progression.
Glioma
Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.
Glioma
Long non-coding RNA MALAT1 promotes proliferation and suppresses apoptosis of glioma cells through derepressing Rap1B by sponging miR-101.
Glioma
Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.
Glioma
LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses.
Glioma
MicroRNA-384 inhibits proliferation migration and invasion of glioma by targeting at CDC42.
Glioma
MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings.
Glioma
miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.
Glioma
NEDD9 regulates 3D migratory activity independent of the Rac1 morphology switch in glioma and neuroblastoma.
Glioma
Oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells transformed with c-myc and H-ras form high-grade glioma after stereotactic injection into the rat brain.
Glioma
Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.
Glioma
Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.
Glioma
Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.
Glioma
Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
Glioma
PTEN gene transfer suppresses the invasive potential of human malignant gliomas by regulating cell invasion-related molecules.
Glioma
Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide.
Glioma
Rab27a was identified as a prognostic biomaker by mRNA profiling, correlated with malignant progression and subtype preference in gliomas.
Glioma
Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.
Glioma
RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
Glioma
Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.
Glioma
Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma.
Glioma
Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells.
Glioma
Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDIalpha-mediated inactivation of Rac1 GTPase.
Glioma
Slit2 inhibits glioma cell invasion in the brain by suppression of Cdc42 activity.
Glioma
SNHG15 affects the growth of glioma microvascular endothelial cells by negatively regulating miR-153.
Glioma
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
Glioma
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.
Glioma
Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility.
Glioma
TRPM7 Induces Mechanistic Target of Rap1b Through the Downregulation of miR-28-5p in Glioma Proliferation and Invasion.
Glioma
Two novel genetic variants in the STK38L and RAB27A genes are associated with glioma susceptibility.
Glioma
Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression.
Glomerulonephritis
C3G overexpression in glomerular epithelial cells during anti-GBM-induced glomerulonephritis.
Glomerulonephritis, Membranous
Role of guanine nucleotide exchange factor-H1 in complement-mediated RhoA activation in glomerular epithelial cells.
Glomerulosclerosis, Focal Segmental
Inverted formin 2-related Charcot-Marie-Tooth disease: extension of the mutational spectrum and pathological findings in Schwann cells and axons.
Glomerulosclerosis, Focal Segmental
Rho-GTPase Activating Protein myosin MYO9A identified as a novel candidate gene for monogenic focal segmental glomerulosclerosis.
Glucose Intolerance
Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
Glucose Intolerance
The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic ?-cells.
Goiter, Nodular
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
Granuloma
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
Granuloma
Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.
Granuloma
Transforming growth factor beta1, ras and p53 in silica-induced fibrogenesis and carcinogenesis.
Granulomatous Disease, Chronic
Reconstitution of defective respiratory burst activity with partially purified human neutrophil cytochrome B in two genetic forms of chronic granulomatous disease: possible role of Rap1A.
Growth Hormone-Secreting Pituitary Adenoma
ras mutations in human prolactinomas and pituitary carcinomas.
Head and Neck Neoplasms
Docetaxel suppresses invasiveness of head and neck cancer cells in vitro.
Head and Neck Neoplasms
Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer.
Head and Neck Neoplasms
Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
Head and Neck Neoplasms
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Head and Neck Neoplasms
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Head and Neck Neoplasms
Mutations in EGFR Signal Pathway in Correlation with Response to Treatment of Head and Neck Cancers.
Head and Neck Neoplasms
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Head and Neck Neoplasms
[Clinical significance of K-RAS and cytokeratine 20 markers in diagnosis of lymphogenic metastasis of pancreatic cancer]
Hearing Loss, Noise-Induced
Noise-induced cochlear F-actin depolymerization is mediated via ROCK2/p-ERM signaling.
Heart Arrest
Global brain ischemia and reperfusion: modifications in eukaryotic initiation factors associated with inhibition of translation initiation.
Heart Diseases
Identification and association of RAC1 gene polymorphisms with mRNA and protein expression levels of Rac1 in solid organ (kidney, liver, heart) transplant recipients.
Heart Diseases
Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease.
Heart Diseases
Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species.
Heart Failure
H-Ras Isoform Mediates Protection Against Pressure Overload-Induced Cardiac Dysfunction in Part Through Activation of AKT.
Heart Failure
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration.
Heart Failure
Redox Signaling by 8-Nitro-cyclic Guanosine Monophosphate: Nitric Oxide- and Reactive Oxygen Species-Derived Electrophilic Messenger.
Heart Failure
Rnd3 haploinsufficient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.
Heart Failure
Simvastatin activates the PPAR?-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling.
Heart Failure
[Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species].
Hemangioma, Cavernous, Central Nervous System
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.
Hemangioma, Cavernous, Central Nervous System
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis.
Hemangioma, Cavernous, Central Nervous System
miR-21 coordinates tumor growth and modulates KRIT1 levels.
Hemangiopericytoma
Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma).
Hemangiosarcoma
Chemical-specific alterations in ras, p53, and beta-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years.
Hemangiosarcoma
Mutational status of K-ras and TP53 genes in primary sarcomas of the heart.
Hemangiosarcoma
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
Hematologic Neoplasms
The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing.
Hematologic Neoplasms
[Characteristics of plasma DNA and its application for detection of K-ras gene mutation]
Hepatitis
Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production.
Hepatitis B
Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
Hepatitis B
Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
Hepatitis B
Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.
Hepatitis B
Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
Hepatitis B
Hepatitis B virus X protein up-regulates oncogene Rab18 to result in the dysregulation of lipogenesis and proliferation of hepatoma cells.
Hepatitis B
Mechanisms of Huangqi Decoction Granules () on Hepatitis B Cirrhosis Patients Based on RNA-Sequencing.
Hepatitis B
Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.
Hepatitis B, Chronic
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Hepatitis C
A single nucleotide polymorphism in activated cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
Hepatitis C
Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
Hepatitis C
Differential Regulation of Lipoprotein and Hepatitis C Virus Secretion by Rab1b.
Hepatitis C
Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene.
Hepatitis C
Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets.
Hepatitis C
Rab18 is required for viral assembly of hepatitis C virus through trafficking of the core protein to lipid droplets.
Hepatitis C
Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Hepatitis C
Supporting Role for GTPase Rab27a in Hepatitis C Virus RNA Replication through a Novel miR-122-Mediated Effect.
Hepatitis C, Chronic
Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras.
Hepatoblastoma
Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
Hepatoblastoma
Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years.
Hepatoblastoma
Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
Hermanski-Pudlak Syndrome
Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.
Hermanski-Pudlak Syndrome
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides.
Hermanski-Pudlak Syndrome
Rab27a regulates the peripheral distribution of melanosomes in melanocytes.
Hermanski-Pudlak Syndrome
RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
Hermanski-Pudlak Syndrome
Rab38 Targets to Lamellar Bodies and Normalizes Their Sizes in Lung Alveolar Type II Epithelial Cells.
Hermanski-Pudlak Syndrome
The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background.
Herpes Simplex
Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells.
Herpes Simplex
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Herpes Simplex
Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes.
Herpes Simplex
Rational screening of oligonucleotide combinatorial libraries for drug discovery.
Herpes Simplex
Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells.
Herpes Simplex
Towards the application of Tc toxins as a universal protein translocation system.
Herpes Zoster
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Herpes Zoster
MicroRNA-15a - cell division cycle 42 signaling pathway in pathogenesis of pediatric inflammatory bowel disease.
Herpes Zoster
The monomeric GTP binding protein, rab3a, is associated with the acrosome in mouse sperm.
Hirschsprung Disease
Quantitative Proteomics Reveals Association of Neuron Projection Development Genes ARF4, KIF5B, and RAB8A With Hirschsprung Disease.
Histiocytic Sarcoma
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Histiocytic Sarcoma
Trametinib and Dabrafenib in histiocytic sarcoma transdifferentiated from chronic lymphocytic leukemia with a K-RAS and a unique BRAF mutation.
Histiocytoma, Benign Fibrous
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Histiocytoma, Malignant Fibrous
H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysis.
Histiocytoma, Malignant Fibrous
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years.
Histiocytoma, Malignant Fibrous
Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature.
Histiocytosis, Langerhans-Cell
Enhanced expression of c-myc and H-ras oncogenes in Letterer-Siwe disease. A sequential study using colorimetric in situ hybridization.
HIV Infections
Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages.
HIV Infections
HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells.
HIV Infections
Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection.
Hodgkin Disease
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
Hodgkin Disease
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Huntington Disease
A Large-scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington's Disease.
Huntington Disease
Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.
Huntington Disease
Dendritic spine loss and neurodegeneration is rescued by Rab11 in models of Huntington's disease.
Huntington Disease
Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease.
Huntington Disease
Rab11 rescues synaptic dysfunction and behavioural deficits in a Drosophila model of Huntington's disease.
Huntington Disease
The role of Rhes, Ras homolog enriched in striatum, in neurodegenerative processes.
Hydatidiform Mole
c-myc, c-erbB-2, c-fms and bcl-2 oncoproteins. Expression in normal placenta, partial and complete mole, and choriocarcinoma.
Hydrocephalus
Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology.
Hydrocephalus
Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice.
Hydrocephalus
Myosin IXa Regulates Epithelial Differentiation and Its Deficiency Results in Hydrocephalus.
Hyperalgesia
Botulinum toxin C3 inhibits hyperalgesia in mice with partial sciatic nerve injury.
Hypercholesterolemia
Simvastatin and ML141 Decrease Intracellular Streptococcus pyogenes Infection.
Hyperglycemia
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases.
Hyperglycemia
High glucose stimulates synthesis of fibronectin via a novel protein kinase C, Rap1b, and B-Raf signaling pathway.
Hyperglycemia
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Hyperglycemia
ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy.
Hyperglycemia
Translocation of H-Ras and its implications in the development of diabetic retinopathy.
Hyperglycemia
Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds.
Hyperhomocysteinemia
Rac1 GTPase Inhibition Blocked Podocyte Injury and Glomerular Sclerosis during Hyperhomocysteinemia via Suppression of Nucleotide-Binding Oligomerization Domain-Like Receptor Containing Pyrin Domain 3 Inflammasome Activation.
Hyperinsulinism
Fetal hyperinsulinemia increases farnesylation of p21 Ras in fetal tissues.
Hyperlipidemias
Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
Hyperpigmentation
Exogenous pyruvate alleviates UV-induced hyperpigmentation via restraining dendrite outgrowth and Rac1 GTPase activity.
Hyperpigmentation
Mosaic analysis and tumor induction in zebrafish by microsatellite instability-mediated stochastic gene expression.
Hypersensitivity
Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B.
Hypersensitivity
Akt2 deficiency promotes cardiac induction of Rab4a and myocardial ?-adrenergic hypersensitivity.
Hypersensitivity
Hypersensitivity of NIH3T3 cells transformed by H-ras gene to DNA-topoisomerase-I inhibitors.
Hypersensitivity
Involvement of Golgi-associated retrograde protein complex in the recycling of the putative Dnf aminophospholipid flippases in yeast.
Hypersensitivity
Rab37 is a novel mast cell specific GTPase localized to secretory granules.
Hypersensitivity
Sumoylation of ABI5 by the Arabidopsis SUMO E3 ligase SIZ1 negatively regulates abscisic acid signaling.
Hypertension
Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.
Hypertension
Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries.
Hypertension
Involvement of Rho GTPases and their regulators in the pathogenesis of hypertension.
Hypertension
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.
Hypertension
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Hypertension
Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation.
Hypertension
Targeted genomic disruption of h-ras induces hypotension through a NO-cGMP-PKG pathway-dependent mechanism.
Hypertension
The effect of afterload and angiotensin II on proto-oncogene mRNA levels in the isolated working rat heart.
Hypertension
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
Hypertension
[Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage]
Hypertension, Pulmonary
Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension.
Hypertrophy, Left Ventricular
Simvastatin activates the PPAR?-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signaling.
Hypopigmentation
Rab GTPases: key players in melanosome biogenesis, transport, and transfer.
Hypopigmentation
The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background.
Hypotension
Targeted genomic disruption of h-ras induces hypotension through a NO-cGMP-PKG pathway-dependent mechanism.
Hypothyroidism
Nutritional, hormonal, and depot-dependent regulation of the expression of the small GTPase Rab18 in rodent adipose tissue.
Hypothyroidism
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Hypothyroidism
Regulation by thyroid status of c-myc, c-fos and H-ras mRNAs in the rat myocardium.
Hypothyroidism
Synaptic and Non-Synaptic Mitochondria in Hippocampus of Adult Rats Differ in Their Sensitivity to Hypothyroidism.
Idiopathic Pulmonary Fibrosis
Downregulation of FAK-related non-kinase mediates the migratory phenotype of human fibrotic lung fibroblasts.
Immune System Diseases
A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH).
Immune System Diseases
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients.
Immune System Diseases
Characterization of a cdc42 protein inhibitor and its use as a molecular probe.
Infarction, Middle Cerebral Artery
Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.
Infections
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Infections
A Cdc42 homolog in Colletotrichum gloeosporioides regulates morphological development and is required for ROS-mediated plant infection.
Infections
A combinatorial approach for selectively inducing programmed cell death in human pancreatic cancer cells.
Infections
A dominant negative mutant of rab5 inhibits infection of cells by foot-and-mouth disease virus; implications for virus entry.
Infections
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
Infections
A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection.
Infections
A Rac1 GTPase is a critical factor in the immune response of shrimp (Litopenaeus vannamei) to Vibrio alginolyticus infection.
Infections
Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin.
Infections
Activation of hypersensitive response genes in the absence of pathogens in transgenic tobacco plants expressing a rice small GTPase.
Infections
Adeno-associated virus 2 infection requires endocytosis through the CLIC/GEEC pathway.
Infections
Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix.
Infections
Analysis of Chlamydia caviae entry sites and involvement of Cdc42 and Rac activity.
Infections
Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.
Infections
Analysis of the proteins synthesized in ultraviolet light-irradiated Escherichia coli following infection with the bacteriophages lambdadrifd 18 and lambdadfus-3.
Infections
Analysis of the Rac/Rop small GTPase family in rice: expression, subcellular localization and role in disease resistance.
Infections
Arabidopsis RAB8A, RAB8B, and RAB8D Proteins Interact with Several RTNLB Proteins and Are Involved in the Agrobacterium tumefaciens Infection Process.
Infections
Beyond Rab GTPases Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.
Infections
Beyond Rab GTPases: Legionella activates the small GTPase Ran to promote microtubule polymerization, pathogen vacuole motility, and infection.
Infections
Bombyx mori nucleopolyhedrovirus utilizes a clathrin and dynamin dependent endocytosis entry pathway into BmN cells.
Infections
Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis.
Infections
Burkholderia cenocepacia infection: Disruption of phagocyte immune functions through Rho GTPase inactivation.
Infections
Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection.
Infections
Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure.
Infections
CD81 is a central regulator of cellular events required for hepatitis C virus infection of human hepatocytes.
Infections
Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation.
Infections
Cdc42 stimulates neurite outgrowth and formation of growth cone filopodia and lamellipodia.
Infections
Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein.
Infections
Cell lines containing and expressing the human herpesvirus 6A ts gene are protected from both H-ras and BPV-1 transformation.
Infections
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions.
Infections
Cloning and Activity Analysis of Promoter of RanGTPase Gene from Shrimp, Marsupenaeus japonicus
Infections
cPLA2 regulates the expression of type I interferons and intracellular immunity to Chlamydia trachomatis.
Infections
Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.
Infections
Detection of hepatitis-B virus-DNA and mutations in k-ras and p53 genes in human hepatocellular carcinomas.
Infections
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Infections
Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection.
Infections
Disruption of epithelial barrier integrity by Salmonella enterica serovar typhimurium requires geranylgeranylated proteins.
Infections
Dot/Icm Effector Translocation by Legionella longbeachae Creates a Replicative Vacuole Similar to That of Legionella pneumophila despite Translocation of Distinct Effector Repertoires.
Infections
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Infections
Drosophila melanogaster S2 cells: a model system to study Chlamydia interaction with host cells.
Infections
Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells.
Infections
Effect of the Rho GTPase inhibitor-1 on the entry of dengue serotype 2 virus into EAhy926 cells.
Infections
Endocytic Rabs Are Recruited to the Trypanosoma cruzi Parasitophorous Vacuole and Contribute to the Process of Infection in Non-professional Phagocytic Cells.
Infections
Enterohaemorrhagic E. coli modulates an ARF6:Rab35 signaling axis to prevent recycling endosome maturation during infection.
Infections
Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells.
Infections
Epithelial chemokine CXCL14 synergizes with CXCL12 via allosteric modulation of CXCR4.
Infections
Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport.
Infections
FgMon1, a guanine nucleotide exchange factor of FgRab7, is important for vacuole fusion, autophagy and plant infection in Fusarium graminearum.
Infections
Gene editing a constitutively active OsRac1 by homologous recombination-based gene targeting induces immune responses in rice.
Infections
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes.
Infections
Graf1 controls the growth of human parainfluenza virus type 2 through inactivation of RhoA signaling.
Infections
H-ras infection in mink lung epithelial cells may induce "atypical" multidrug resistance.
Infections
High-level expression of H-ras and c-myc oncogenes in mycoplasma-mediated malignant cell transformation.
Infections
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Infections
Identification and cloning of two immunogenic Clostridium perfringens proteins, elongation factor Tu (EF-Tu) and pyruvate:ferredoxin oxidoreductase (PFO) of C. perfringens.
Infections
Identification and functional analysis of inflammation-related miRNAs in skin wound repair.
Infections
Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection.
Infections
Identification of cognate host targets and specific ubiquitylation sites on the Salmonella SPI-1 effector SopB/SigD.
Infections
Identification of host trafficking genes required for HIV-1 virological synapse formation in dendritic cells.
Infections
Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen.
Infections
Identification of Rab27a as a host factor for oncolytic herpes virus susceptibility to tumor cells.
Infections
Immunogenicity and protective capacity of EF-Tu and FtsZ of Streptococcus suis serotype 2 against lethal infection.
Infections
Impact of Rac1 and Cdc42 signaling during early herpes simplex virus type 1 infection of keratinocytes.
Infections
Influenza A virus progeny vRNP trafficking in live infected cells studied with the virus-encoded fluorescently tagged PB2 protein.
Infections
Influenza A virus ribonucleoproteins modulate host recycling by competing with Rab11 effectors.
Infections
Inhibition of Cdc42-dependent signalling in Saccharomyces cerevisiae by phosphatase-dead SigD/SopB from Salmonella typhimurium.
Infections
Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
Infections
Intracellular Uropathogenic E. coli Exploits Host Rab35 for Iron Acquisition and Survival within Urinary Bladder Cells.
Infections
Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity.
Infections
IQGAP1 regulates salmonella invasion through interactions with actin, Rac1, and Cdc42.
Infections
K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia.
Infections
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
Infections
Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion.
Infections
KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics.
Infections
Lack of p53 and ras mutations in Helicobacter hepaticus-induced liver tumors in A/JCr mice.
Infections
Legionella pneumophila infection is enhanced in a RacH-null mutant of Dictyostelium.
Infections
Macropinocytotic uptake and infection of human epithelial cells with species B2 adenovirus type 35.
Infections
Major Host Factors Involved in Epithelial Cell Invasion of Campylobacter jejuni: Role of Fibronectin, Integrin Beta1, FAK, Tiam-1, and DOCK180 in Activating Rho GTPase Rac1.
Infections
Membrane trafficking RNA interference screen identifies a crucial role of the clathrin endocytic pathway and ARP2/3 complex for Japanese encephalitis virus infection in HeLa cells.
Infections
Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
Infections
MiR-199a Inhibits Secondary Envelopment of Herpes Simplex Virus-1 Through the Downregulation of Cdc42-specific GTPase Activating Protein Localized in Golgi Apparatus.
Infections
Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum.
Infections
Molecular cloning and characterization of Ras- and Raf-homologues from the fox-tapeworm Echinococcus multilocularis.
Infections
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation.
Infections
Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.
Infections
Mycoplasma infection suppresses p53, activates NF-kappaB and cooperates with oncogenic Ras in rodent fibroblast transformation.
Infections
NSC23766 and Ehop016 Suppress Herpes Simplex Virus-1 Replication by Inhibiting Rac1 Activity.
Infections
Overexpression of microRNA-133b reduces myocardial injuries in children with viral myocarditis by targeting Rab27B gene.
Infections
Overexpression of vascular endothelial growth factor isoforms drives oxygenation and growth but not progression to glioblastoma multiforme in a human model of gliomagenesis.
Infections
Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: Expanding the Molecular and Phenotypic Spectrum.
Infections
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Infections
Pathogenicity island-dependent activation of Rho GTPases Rac1 and Cdc42 in Helicobacter pylori infection.
Infections
Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42.
Infections
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.
Infections
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
Infections
rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion.
Infections
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Infections
Rab1b-GBF1-ARFs mediated intracellular trafficking is required for classical swine fever virus replication in swine umbilical vein endothelial cells.
Infections
Rab27a facilitates human parainfluenza virus type 2 growth by promoting cell surface transport of envelope proteins.
Infections
Rab27a is essential for the formation of neutrophil extracellular traps (NETs) in neutrophil-like differentiated HL60 cells.
Infections
Rab27b regulates extracellular vesicle production in cells infected with Kaposi's sarcoma-associated herpesvirus to promote cell survival and persistent infection.
Infections
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells.
Infections
Rab5 and Rab7, but not ARF6, govern the early events of HIV-1 infection in polarized human placental cells.
Infections
Rab5 Enhances Classical Swine Fever Virus Proliferation and Interacts with Viral NS4B Protein to Facilitate Formation of NS4B Related Complex.
Infections
Rac1 and Cdc42 GTPases cross-talk regulates formation of filopodia required for Dengue virus type-2 entry into HMEC-1 cells.
Infections
Rac1-dependent endocytosis and Rab5-dependent intracellular trafficking are required by Enterovirus A71 and Coxsackievirus A10 to establish infections.
Infections
Rac2 is a major actor of Drosophila resistance to Pseudomonas aeruginosa acting in phagocytic cells.
Infections
RalF-Mediated Activation of Arf6 Controls Rickettsia typhi Invasion by Co-Opting Phosphoinositol Metabolism.
Infections
Real-time imaging of Leishmania mexicana-infected early phagosomes: a study using primary macrophages generated from green fluorescent protein-Rab5 transgenic mice.
Infections
RhoA signaling is required for respiratory syncytial virus-induced syncytium formation and filamentous virion morphology.
Infections
RhoGTPase activation is a key step in renal epithelial mesenchymal transdifferentiation.
Infections
Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells.
Infections
Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.
Infections
Rsr1 Palmitoylation and GTPase Activity Status Differentially Coordinate Nuclear, Septin, and Vacuole Dynamics in Candida albicans.
Infections
Salmon cells SHK-1 internalize infectious pancreatic necrosis virus by macropinocytosis.
Infections
Silencing of the Rac1 GTPase MtROP9 in Medicago truncatula stimulates early mycorrhizal and oomycete root colonizations but negatively affects rhizobial infection.
Infections
Small GTPase Immunity-Associated Proteins Mediate Resistance to Toxoplasma gondii Infection in Lewis Rat.
Infections
Small GTPase Rab8a-recruited Phosphatidylinositol 3-Kinase ? Regulates Signaling and Cytokine Outputs from Endosomal Toll-like Receptors.
Infections
Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus.
Infections
Soft-shelled turtle iridovirus enters cells via cholesterol-dependent, clathrin-mediated endocytosis as well as macropinocytosis.
Infections
Statins disrupt CCR5 and RANTES expression levels in CD4+ T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1.
Infections
Structural basis for RNA-genome recognition during bacteriophage Q? replication.
Infections
Structure of the Qbeta replicase, an RNA-dependent RNA polymerase consisting of viral and host proteins.
Infections
Study on the association between Helicobacter pylori infection and the pathogenesis of gastric cancer by using molecular biological techniques.
Infections
Substrate recognition by the Pseudomonas aeruginosa EF-Tu-modifying methyltransferase EftM.
Infections
Temporal regulation of salmonella virulence effector function by proteasome-dependent protein degradation.
Infections
The autophagic pathway is actively modulated by phase II Coxiella burnetii to efficiently replicate in the host cell.
Infections
The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA.
Infections
The Differential Expression and Possible Function of Long Noncoding RNAs in Liver Cells Infected by Dengue Virus.
Infections
The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity.
Infections
The Early Secretory Pathway Contributes to the Growth of the Coxiella-replicative Niche.
Infections
The GTPase Rab4 interacts with Chlamydia trachomatis inclusion membrane protein CT229.
Infections
The Hematopoietic Cell-Specific Rho GTPase Inhibitor ARHGDIB/D4GDI Limits HIV Type 1 Replication.
Infections
The interplay between the Escherichia coli Rho guanine nucleotide exchange factor effectors and the mammalian RhoGEF inhibitor EspH.
Infections
The late endocytic Rab39a GTPase regulates the interaction between multivesicular bodies and chlamydial inclusions.
Infections
The monomeric GTPase RabA2 is required for progression and maintenance of membrane integrity of infection threads during root nodule symbiosis.
Infections
The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42.
Infections
The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death.
Infections
The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes.
Infections
The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors.
Infections
The small GTPase NtRHO1 negatively regulates tobacco defense response to Tobacco mosaic virus by interacting with NtWRKY50.
Infections
The Small GTPase Rab5c Exerts Bi-Function in Singapore Grouper Iridovirus Infections and Cellular Responses in the Grouper, Epinephelus coioides.
Infections
The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection.
Infections
Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity.
Infections
Two closely related Rho GTPases, Cdc42 and RacA, of the en-dophytic fungus Epichloë festucae have contrasting roles for ROS production and symbiotic infection synchronized with the host plant.
Infections
Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases.
Infections
Vibrio parahaemolyticus Infection Influenced Trace Element Homeostasis, Impaired Antioxidant Function, and Induced Inflammation Response in Litopenaeus vannamei.
Infections
[Evaluation of K-ras 12 oncogene mutations in Venezuelan patients with Helicobacter pylori infection]
Infections
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
Infertility
Alterations in seminal plasma proteomic profile in men with primary and secondary infertility.
Infertility
CDC42 controls the activation of primordial follicles by regulating PI3K signaling in mouse oocytes.
Infertility, Female
Specific deletion of Cdc42 does not affect meiotic spindle organization/migration and homologous chromosome segregation but disrupts polarity establishment and cytokinesis in mouse oocytes.
Inflammatory Bowel Diseases
Analysis of mutations in TP53, APC, K-ras, and DCC genes in the non-dysplastic mucosa of patients with inflammatory bowel disease.
Inflammatory Bowel Diseases
Dislocation of Rab13 and vasodilator-stimulated phosphoprotein in inactive colon epithelium in patients with Crohn's disease.
Inflammatory Bowel Diseases
Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool.
Inflammatory Bowel Diseases
Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis.
Inflammatory Bowel Diseases
K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
Inflammatory Bowel Diseases
Kruppel-like factor 6 (KLF6) is a tumor-suppressor gene frequently inactivated in colorectal cancer.
Inflammatory Bowel Diseases
Mice lacking myosin IXb, an inflammatory bowel disease susceptibility gene, have impaired intestinal barrier function and superficial ulceration in the ileum.
Inflammatory Bowel Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Inflammatory Bowel Diseases
Rac Attack: Modulation of the Small GTPase Rac in Inflammatory Bowel Disease and Thiopurine Therapy.
Inflammatory Bowel Diseases
Screening for p53 and K-ras mutations in whole-gut lavage in chronic inflammatory bowel disease.
Influenza, Human
A Comprehensive Review on the Interaction Between the Host GTPase Rab11 and Influenza A Virus.
Influenza, Human
A Peptide Derived from Phosphoinositide 3-kinase Inhibits Endocytosis and Influenza Virus Infection.
Influenza, Human
A Rab11 and microtubule dependent mechanism for cytoplasmic transport of influenza A virus vRNA.
Influenza, Human
Binding of ras oncogene peptides to purified HLA-DQ(alpha 1*0102,beta 1*0602) and -DR(alpha,beta 1*0101) molecules.
Influenza, Human
Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the elF-2 translation initiation factor.
Influenza, Human
Clustering of Rab11 vesicles in influenza A virus infected cells creates hotspots containing the 8 viral ribonucleoproteins.
Influenza, Human
Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet h-ras diffusion and signaling.
Influenza, Human
Fluorescent protein-based biosensors to visualize signal transduction beneath the plasma membrane.
Influenza, Human
Influenza A virus ribonucleoproteins modulate host recycling by competing with Rab11 effectors.
Influenza, Human
On the role of electrostatic interactions in the design of protein-protein interfaces.
Influenza, Human
The Rab11 pathway is required for influenza A viral budding and filament formation.
Influenza, Human
The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity.
Influenza, Human
Transport of influenza A virus neuraminidase (NA) to host cell surface is regulated by ARHGAP21 and Cdc42.
Influenza, Human
YRKL sequence of influenza virus M1 functions as the L domain motif and interacts with VPS28 and Cdc42.
Influenza, Human
[Mechanism underlying the anterograde transport of the influenza A virus transmembrane proteins and genome in host cytoplasm].
Insulin Resistance
IFN-?/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
Insulin Resistance
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating P53 and RAP2A in vitro and in vivo [Retraction].
Insulin Resistance
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo.
Insulin Resistance
Rac1 muscle knockout exacerbates the detrimental effect of high-fat diet on insulin-stimulated muscle glucose uptake independently of Akt.
Insulinoma
Analysis of selected genes in neuroendocrine tumours: insulinomas and phaeochromocytomas.
Insulinoma
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
Insulinoma
Expression of the ras-related rab3a gene in human insulinomas and normal human pancreatic islets.
Insulinoma
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Insulinoma
Rab8a is involved in membrane trafficking of Kir6.2 in the MIN6 insulinoma cell line.
Insulinoma
Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation.
Intellectual Disability
Alteration of synaptic network dynamics by the intellectual disability protein PAK3.
Intellectual Disability
Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes.
Intellectual Disability
CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.
Intellectual Disability
De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay.
Intellectual Disability
Diverse roles of Rho family GTPases in neuronal development, survival, and death.
Intellectual Disability
Dysregulation of Rho GTPases in the ?Pix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
Intellectual Disability
Exon 21 deletion in the OPHN1 gene in a family with syndromic X-linked intellectual disability: Case report.
Intellectual Disability
From fragile X mental retardation protein to Rac1 GTPase: new insights from Fly CYFIP.
Intellectual Disability
Impairment of fragile X mental retardation protein-metabotropic glutamate receptor 5 signaling and its downstream cognates ras-related C3 botulinum toxin substrate 1, amyloid beta A4 precursor protein, striatal-enriched protein tyrosine phosphatase, and homer 1, in autism: a postmortem study in cerebellar vermis and superior frontal cortex.
Intellectual Disability
LRCH1 interferes with DOCK8-Cdc42-induced T cell migration and ameliorates experimental autoimmune encephalomyelitis.
Intellectual Disability
Neuropathophysiological significance of the c.1449T>C/p.(Tyr64Cys) mutation in the CDC42 gene responsible for Takenouchi-Kosaki syndrome.
Intellectual Disability
p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis.
Intellectual Disability
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Intellectual Disability
Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability.
Intellectual Disability
Platelet lamellipodium formation is not required for thrombus formation and stability.
Intellectual Disability
Rho GTPase signaling at the synapse: Implications for intellectual disability.
Intellectual Disability
Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.
Intellectual Disability
ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
Intellectual Disability
The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation.
Intellectual Disability
The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation.
Intellectual Disability
Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.
Intellectual Disability
Variants in the RAB3A gene are not associated with mental retardation in the Chinese population.
Intestinal Neoplasms
Detection of K-ras gene mutation in fecal samples from elderly large intestinal cancer patients and its diagnostic significance.
Intestinal Neoplasms
Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
Intestinal Neoplasms
TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells.
Intestinal Polyposis
KLF5 mediates the hyper-proliferative phenotype of the intestinal epithelium in mice with intestine-specific endogenous K-RasG12D expression.
Irritable Bowel Syndrome
Genetic variants in CDC42 and NXPH1 as susceptibility factors for constipation and diarrhoea predominant irritable bowel syndrome.
Ischemic Attack, Transient
Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage.
Ischemic Stroke
Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice.
Ischemic Stroke
Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mouse model of permanent ischemic stroke.
Ischemic Stroke
Small GTPase RhoA and its effector rho kinase mediate oxygen glucose deprivation-evoked in vitro cerebral barrier dysfunction.
Ischemic Stroke
SVCT2 Promotes Neural Stem/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke.
Keratoacanthoma
Differential expression of the H-ras mutated and normal alleles in rabbit DMBA-induced keratoacanthomas.
Keratoacanthoma
H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.
Keratoacanthoma
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Keratoacanthoma
Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
Kidney Diseases
A Point Mutation in p190A RhoGAP Affects Ciliogenesis and Leads to Glomerulocystic Kidney Defects.
Kidney Diseases
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Kidney Diseases
Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
Kidney Diseases
Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice.
Kidney Diseases
Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.
Kidney Diseases
Rac1 GTPase in rodent kidneys is essential for salt-sensitive hypertension via a mineralocorticoid receptor-dependent pathway.
Kidney Diseases, Cystic
Aberrant regulation of planar cell polarity in polycystic kidney disease.
Kidney Failure, Chronic
RhoA, Rho kinase, JAK2, and STAT3 may be the intracellular determinants of longevity implicated in the progeric influence of obesity: Insulin, IGF-1, and leptin may all conspire to promote stem cell exhaustion.
Kidney Neoplasms
Chromosomal abnormalities and gene amplification in renal cancers induced in rats by nickel subsulfide.
Kidney Neoplasms
Heme oxygenase-1 is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK Pathway, and mediates anti-apoptotic signal.
Kidney Neoplasms
Prostaglandin E2 regulates renal cell carcinoma invasion through a EP4-Rap signal transduction pathway.
Kidney Neoplasms
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Kidney Neoplasms
Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating ?-Catenin Signaling.
Klatskin Tumor
Alterations of the p53 tumor-suppressor gene and K-ras oncogene in perihilar cholangiocarcinomas from a high-incidence area.
Laryngeal Neoplasms
Expression of ras oncogene p21 protein in normal and neoplastic laryngeal tissues: correlation with histopathological features and epidermal growth factor receptors.
Laryngeal Neoplasms
High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas.
Laryngeal Neoplasms
Metabolic activation, DNA adducts, and H-ras mutations in human neoplastic and non-neoplastic laryngeal tissue.
Laryngeal Neoplasms
Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through caspase- and mitochondria-dependent pathways.
Laryngeal Neoplasms
[Express of human papillomavirus, P53 and H-ras gene in laryngeal cancer]
Laryngeal Neoplasms
[Oncogenes and cancer of the larynx. EGFR, p21 ras and HPV-DNA infections]
Latent Infection
The guanine exchange factor SWAP70 mediates vGPCR-induced endothelial plasticity.
Latent Tuberculosis
Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks.
Leiomyoma
Aspirin inhibits the proliferation of human uterine leiomyoma cells by downregulation of K?Ras?p110? interaction.
Leiomyoma
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Leiomyoma
Identification of Differentially Expressed K-Ras Transcript Variants in Patients With Leiomyoma.
Leiomyosarcoma
Detection of transforming genes by transfection of DNA from primary soft-tissue tumours.
Leiomyosarcoma
H-ras and K-ras gene mutations in primary human soft tissue sarcoma: concomitant mutations of the ras genes.
Leishmaniasis, Visceral
Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis.
Leukemia
Accuracy of DNA amplification from archival hematological slides for use in genetic biomarker studies.
Leukemia
Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction.
Leukemia
Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion.
Leukemia
Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
Leukemia
Conditional immortalization and/or transformation of rat cells carrying v-abl or EJras oncogene in the presence or absence of glucocorticoid hormone.
Leukemia
Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene.
Leukemia
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Leukemia
Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia.
Leukemia
Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice.
Leukemia
Effect of Clostridium difficile toxin B on IgE receptor-mediated signal transduction in rat basophilic leukemia cells: inhibition of phospholipase D activation.
Leukemia
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Leukemia
Eicosapentaenoic acid activates RAS/ERK/C/EBP? pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells.
Leukemia
Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia.
Leukemia
Expression of a constitutively active mutant of M-Ras in normal bone marrow is sufficient for induction of a malignant mastocytosis/mast cell leukemia, distinct from the histiocytosis/monocytic leukemia induced by expression of activated H-Ras.
Leukemia
Expression of endogenous retrovirus-like sequences and cellular oncogenes during phenobarbital treatment and regeneration in rat liver.
Leukemia
Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.
Leukemia
Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia.
Leukemia
Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
Leukemia
Growth properties, differentiation capacity and oncogene expression in metastatic and nonmetastatic Friend leukemia cell variants.
Leukemia
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
Leukemia
Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.
Leukemia
Involvement of Rab27 in antigen-induced histamine release from rat basophilic leukemia 2H3 cells.
Leukemia
K-ras mutations and N-ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements.
Leukemia
KRAS (G12D) Cooperates with AML1/ETO to Initiate a Mouse Model Mimicking Human Acute Myeloid Leukemia.
Leukemia
Lack of noncanonical RAS mutations in cytogenetically normal acute myeloid leukemia.
Leukemia
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
Leukemia
Leukemogenic risk of hydroxyurea therapy as a single agent in polycythemia vera and essential thrombocythemia: N- and K-ras mutations and microsatellite instability in chromosomes 5 and 7 in 69 patients.
Leukemia
Low frequency of ras oncogene mutations in Philadelphia-positive acute leukemia and report of a novel mutation H61 Leu in a single case.
Leukemia
MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway.
Leukemia
Phospholipase C gamma negatively regulates Rac/Cdc42 activation in antigen-stimulated mast cells.
Leukemia
Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in Drosophila.
Leukemia
Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells.
Leukemia
Rac and phosphatidylinositol 3-kinase regulate the protein kinase B in Fc epsilon RI signaling in RBL 2H3 mast cells.
Leukemia
Rac1 GTPase promotes interaction of hematopoietic stem/progenitor cell with niche and participates in leukemia initiation and maintenance in mouse.
Leukemia
Rearrangement and expression of T cell receptor and immunoglobulin loci in immortalized CD4-CD8- T cell lines.
Leukemia
Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells.
Leukemia
Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcepsilonRI-activated rat basophilic leukemia (RBL-2H3) cells.
Leukemia
The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.
Leukemia
The hematopoietically expressed vav proto-oncogene shares homology with the dbl GDP-GTP exchange factor, the bcr gene and a yeast gene (CDC24) involved in cytoskeletal organization.
Leukemia
The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.
Leukemia
The TLR9 agonist (GNKG168) induces a unique immune activation pattern in vivo in children with minimal residual disease positive acute leukemia: Results of the TACL T2009-008 phase I study.
Leukemia
Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.
Leukemia
Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway.
Leukemia
[Application of flow cytometry to the study of hematologic disorders: analysis of oncogene products]
Leukemia
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
Leukemia, Erythroblastic, Acute
Defective RAB1B-related megakaryocytic ER-to-Golgi transport in RUNX1 haplodeficiency: impact on von Willebrand factor.
Leukemia, Lymphocytic, Chronic, B-Cell
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Leukemia, Lymphocytic, Chronic, B-Cell
Absence of Kirsten-ras oncogene activation in B-cell chronic lymphocytic leukemia.
Leukemia, Lymphocytic, Chronic, B-Cell
Chronic lymphocytic leukemia cells induce defective LFA-1-directed T cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.
Leukemia, Lymphocytic, Chronic, B-Cell
The Phospholipase C-?2 Mutants R665W and L845F Identified in Ibrutinib-Resistant Chronic Lymphocytic Leukemia Patients are Hypersensitive to the Rho GTPase Rac2.
Leukemia, Lymphocytic, Chronic, B-Cell
Trametinib and Dabrafenib in histiocytic sarcoma transdifferentiated from chronic lymphocytic leukemia with a K-RAS and a unique BRAF mutation.
Leukemia, Lymphoid
N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Activation of Harvey ras oncogene by mutation at codon 12 is very rare in hemopoietic malignancies.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Induction of apoptosis by a dominant negative H-RAS mutant (116Y) in K562 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Inhibition of small GTPase RalA regulates growth and arsenic-induced apoptosis in chronic myeloid leukemia (CML) cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
p210(Bcr-Abl) desensitizes Cdc42 GTPase signaling for SDF-1alpha-directed migration in chronic myeloid leukemia cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Ras oncogene mutations are rare late stage events in chronic myelogenous leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Small GTPase RAB45-mediated p38 activation in apoptosis of chronic myeloid leukemia progenitor cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Southern blot analysis of Bcr, N-ras, H-ras, c-myc and myb proto-oncogenes in blast crisis of chronic myelogenous leukemia.
Leukemia, Myeloid
Activation of Rac1 GTPase promotes leukemia cell chemotherapy resistance, quiescence and niche interaction.
Leukemia, Myeloid
Mutant H-ras over-expression inhibits a random apoptotic nuclease in myeloid leukemia cells.
Leukemia, Myeloid
Mutant RAS selectively promotes sensitivity of myeloid leukemia cells to apoptosis by a protein kinase C-dependent process.
Leukemia, Myeloid
Synergistic cytotoxic effects in myeloid leukemia cells upon cotreatment with farnesyltransferase and geranylgeranyl transferase-I inhibitors.
Leukemia, Myeloid, Acute
A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer.
Leukemia, Myeloid, Acute
Active oral regimen for elderly adults with newly diagnosed acute myelogenous leukemia: a preclinical and phase 1 trial of the farnesyltransferase inhibitor tipifarnib (R115777, Zarnestra) combined with etoposide.
Leukemia, Myeloid, Acute
ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias.
Leukemia, Myeloid, Acute
Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1 dependent manner.
Leukemia, Myeloid, Acute
Cell Polarity and Division Symmetry Analyses in Transformed Blood Cells.
Leukemia, Myeloid, Acute
Correlated flow cytometric analysis of H-ras p21 and DNA ploidy in acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Detection of high incidence of H-RAS oncogene point mutations in acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Detection of N-RAS and K-RAS in their active GTP-bound form in acute myeloid leukemia without activating RAS mutations.
Leukemia, Myeloid, Acute
Expression of normal and mutant ras proteins in human acute leukemia.
Leukemia, Myeloid, Acute
Features of Ras activation by a mislocalized oncogenic tyrosine kinase: FLT3 ITD signals via K-Ras at the plasma membrane of Acute Myeloid Leukemia cells.
Leukemia, Myeloid, Acute
MBD3/NuRD loss participates with KDM6A program to promote DOCK5/8 expression and Rac GTPase activation in human acute myeloid leukemia.
Leukemia, Myeloid, Acute
miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.
Leukemia, Myeloid, Acute
Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia.
Leukemia, Myeloid, Acute
Mutational analysis of K-ras codon 12 in blood samples of patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes.
Leukemia, Myeloid, Acute
Nf1 deficiency co-operates with oncogenic K-RAS to induce acute myeloid leukemia in mice.
Leukemia, Myeloid, Acute
Oncogenic K-ras in mouse models of myeloproliferative disease and acute myeloid leukemia.
Leukemia, Myeloid, Acute
Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.
Leukemia, Myeloid, Acute
Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.
Leukemia, Myeloid, Acute
Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.
Leukemia, Myeloid, Acute
The Prognostic Impact of K-RAS Mutations in Adult Acute Myeloid Leukemia Patients Treated with High Dose Cytarabine.
Leukemia, Myeloid, Acute
The prognostic impact of K-RAS mutations in adult acute myeloid leukemia patients treated with high-dose cytarabine.
Leukemia, Myelomonocytic, Juvenile
A novel somatic K-Ras mutation in juvenile myelomonocytic leukemia.
Leukemia, Plasma Cell
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
Leukemia, Promyelocytic, Acute
Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia.
Leukemia, Promyelocytic, Acute
Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells.
Leukemia, Radiation-Induced
Cytogenetic and molecular changes in leukemia found among atomic bomb survivors.
Leukemia, Radiation-Induced
Mutation of RAS oncogene in atomic bomb radiation-exposed leukemia.
Leukemia, T-Cell
Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia.
Leukemia, T-Cell
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors.
Leukemia-Lymphoma, Adult T-Cell
Decoding pathogenesis factors involved in the progression of ATLL or HAM/TSP after infection by HTLV-1 through a systems virology study.
Leukoencephalopathies
Novel mutation in mitochondrial Elongation Factor EF-Tu associated to dysplastic leukoencephalopathy and defective mitochondrial DNA translation.
Leukopenia
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia.
Lewy Body Disease
Abnormal alpha-synuclein interactions with rab3a and rabphilin in diffuse Lewy body disease.
Lipoblastoma
Identification of COL3A1 and RAB2A as novel translocation partner genes of PLAG1 in lipoblastoma.
Lipoma
Association of LPP and TAGAP Polymorphisms with Celiac Disease Risk: A Meta-Analysis.
Liposarcoma
Detection of transforming genes by transfection of DNA from primary soft-tissue tumours.
Liposarcoma
H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysis.
Liver Cirrhosis
HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.
Liver Cirrhosis
Liver X receptors balance lipid stores in hepatic stellate cells via Rab18, a retinoid responsive lipid droplet protein.
Liver Cirrhosis, Experimental
H-ras oncogene expression and angiogenesis in experimental liver cirrhosis.
Liver Diseases
Integrated Analysis and Identification of Novel Biomarkers in Parkinson's Disease.
Liver Diseases
Pre-operative chemotherapy for colorectal cancer liver metastases: an update of recent clinical trials.
Liver Neoplasms
Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.
Liver Neoplasms
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Liver Neoplasms
Altered gene expression and genetic damage in North American fish populations.
Liver Neoplasms
Anti-tumor Properties of Picrasma quassioides Extracts in H-RasG12V Liver Cancer Are Mediated Through ROS-dependent Mitochondrial Dysfunction.
Liver Neoplasms
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
Liver Neoplasms
Design, Graph Theoretical Analysis and Insilico Modeling of Dunaliella bardawil Biomass Encapsulated N-Succinyl Chitosan Nanoparticles for Enhanced Anticancer Activity.
Liver Neoplasms
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
Liver Neoplasms
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
Liver Neoplasms
DLC1 suppresses NF-?B activity in prostate cancer cells due to its stabilizing effect on adherens junctions.
Liver Neoplasms
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
Liver Neoplasms
Downregulation of serum RAB27B confers improved prognosis and is associated with hepatocellular carcinoma progression through PI3K-AKT-P21 signaling.
Liver Neoplasms
Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
Liver Neoplasms
Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years.
Liver Neoplasms
Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mechanisms.
Liver Neoplasms
Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform.
Liver Neoplasms
Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway.
Liver Neoplasms
Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.
Liver Neoplasms
Impact of Helicobacter hepaticus infection in B6C3F1 mice from twelve National Toxicology Program two-year carcinogenesis studies.
Liver Neoplasms
NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in Swiss-Webster and B6C3F1 Mice (Feed Studies).
Liver Neoplasms
Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo.
Liver Neoplasms
Proto-Oncogene Serine/Threonine Kinase PIM3 Promotes Cell Migration via Modulating Rho GTPase Signaling.
Liver Neoplasms
Rab27B enhances drug resistance in hepatocellular carcinoma by promoting exosome-mediated drug efflux.
Liver Neoplasms
Rho GTPase activating protein cDNA on chromosome 13q12 is the deleted in liver cancer (DLC2) gene.
Liver Neoplasms
Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
Liver Neoplasms
Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.
Liver Neoplasms
The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.
Liver Neoplasms
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
Lung Diseases
A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice.
Lung Diseases
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
Lung Diseases
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Lung Diseases
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
Lung Diseases, Interstitial
Expression and alteration of ras and p53 proteins in patients with lung carcinoma accompanied by idiopathic pulmonary fibrosis.
Lung Diseases, Interstitial
K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.
Lung Injury
Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Lung Injury
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice.
Lung Injury
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Lung Injury
Inactivation of Rab11a GTPase in Macrophages Facilitates Phagocytosis of Apoptotic Neutrophils.
Lung Injury
Neuronal Wiskott-Aldrich syndrome protein regulates TGF-?1-mediated lung vascular permeability.
Lung Injury
Oxidized phospholipids reduce ventilator-induced vascular leak and inflammation in vivo.
Lung Injury
Small GTPase RAB6 deficiency promotes alveolar progenitor cell renewal and attenuates PM2.5-induced lung injury and fibrosis.
Lung Neoplasms
A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis.
Lung Neoplasms
A cross-sectional study examining the expression of splice variants K-RAS4A and K-RAS4B in advanced non-small-cell lung cancer patients.
Lung Neoplasms
A detailed immunohistochemical analysis of the PI3K/AKT/mTOR pathway in lung cancer: correlation with PIK3CA, AKT1, K-RAS or PTEN mutational status and clinicopathological features.
Lung Neoplasms
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis.
Lung Neoplasms
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
Lung Neoplasms
A genetic mouse model for metastatic lung cancer with gender differences in survival.
Lung Neoplasms
A novel combination of K-ras and myc amplification accompanied by point mutational activation of K-ras in a human lung cancer.
Lung Neoplasms
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
Lung Neoplasms
A personalized treatment for lung cancer: molecular pathways, targeted therapies, and genomic characterization.
Lung Neoplasms
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Lung Neoplasms
Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells.
Lung Neoplasms
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer.
Lung Neoplasms
Additional value of K-ras point mutations in bronchial wash fluids for diagnosis of peripheral lung tumours.
Lung Neoplasms
Adenoviral-Vector Based siRNA for Mutant K-ras as a Promising Tool for Lung Cancer Gene Therapy: A License to Kill.
Lung Neoplasms
Aerosol delivery of glucosylated polyethylenimine/phosphatase and tensin homologue deleted on chromosome 10 complex suppresses Akt downstream pathways in the lung of K-ras null mice.
Lung Neoplasms
Aerosol delivery of lentivirus-mediated O-glycosylation mutant osteopontin suppresses lung tumorigenesis in K-ras (LA1) mice.
Lung Neoplasms
Aerosol delivery of urocanic acid-modified chitosan/programmed cell death 4 complex regulated apoptosis, cell cycle, and angiogenesis in lungs of K-ras null mice.
Lung Neoplasms
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Lung Neoplasms
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
Lung Neoplasms
An overview of farnesyltransferase inhibitors and their role in lung cancer therapy.
Lung Neoplasms
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome.
Lung Neoplasms
Analysis of K-ras, p53, bcl-2 and Rb expression in non-small cell lung cancer cell lines.
Lung Neoplasms
Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice.
Lung Neoplasms
ARVCF expression is significantly correlated with the malignant phenotype of non-small cell lung cancer.
Lung Neoplasms
Assessment of EGFR and K-ras mutations in fixed and fresh specimens from transesophageal ultrasound-guided fine needle aspiration in non-small cell lung cancer patients.
Lung Neoplasms
Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes.
Lung Neoplasms
Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer.
Lung Neoplasms
Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients.
Lung Neoplasms
Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
Lung Neoplasms
Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
Lung Neoplasms
Avicin G is a potent sphingomyelinase inhibitor and blocks oncogenic K- and H-Ras signaling.
Lung Neoplasms
Biodistribution and Pharmacokinetics Study of siRNA-loaded Anti-NTSR1-mAb-functionalized Novel Hybrid Nanoparticles in a Metastatic Orthotopic Murine Lung Cancer Model.
Lung Neoplasms
Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.
Lung Neoplasms
c-Jun N-terminal kinase contributes to aberrant retinoid signaling in lung cancer cells by phosphorylating and inducing proteasomal degradation of retinoic acid receptor alpha.
Lung Neoplasms
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
Lung Neoplasms
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Lung Neoplasms
Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry.
Lung Neoplasms
Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas.
Lung Neoplasms
CHUK/IKK-? loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation.
Lung Neoplasms
Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status.
Lung Neoplasms
Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
Lung Neoplasms
Clonal origin of multiple lung cancers: K-ras and p53 mutations determined by nonradioisotopic single-strand conformation polymorphism analysis.
Lung Neoplasms
Co-dependency of PKC? and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.
Lung Neoplasms
Combination Therapy of NSCLC Using Hsp90 Inhibitor and Doxorubicin Carrying Functional Nanoceria.
Lung Neoplasms
Combination therapy targeting BCL6 and phospho-STAT3 defeats intra-tumor heterogeneity in a subset of non-small cell lung cancers.
Lung Neoplasms
Comment on "Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-call lung cancer patients" (Cancer Letters 2003;193:207-216).
Lung Neoplasms
Comparative Screening of K-ras Mutations in Colorectal Cancer and Lung Cancer Patients Using a Novel Real-Time PCR with ADx-K-ras Kit and Sanger DNA Sequencing.
Lung Neoplasms
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
Lung Neoplasms
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Lung Neoplasms
Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer.
Lung Neoplasms
Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase.
Lung Neoplasms
Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
Lung Neoplasms
COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1? mediated tumor angiogenesis and proliferation.
Lung Neoplasms
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
Lung Neoplasms
CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer.
Lung Neoplasms
Curcumin Inhibits COPD-Like Airway Inflammation and Lung Cancer Progression in Mice.
Lung Neoplasms
Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.
Lung Neoplasms
Cytoplasmic P120ctn Promotes Gefitinib Resistance in Lung Cancer Cells by Activating PAK1 and ERK Pathway.
Lung Neoplasms
DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor.
Lung Neoplasms
Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-ras(LA2) mice.
Lung Neoplasms
DEPENDENCE ON THE MUC1-C ONCOPROTEIN IN NON-SMALL CELL LUNG CANCER CELLS WITH EGFR AND K-RAS MUTATIONS.
Lung Neoplasms
Deregulation of DUSP activity in EGFR-mutant lung cancer cell lines contributes to sustained ERK1/2 signaling.
Lung Neoplasms
Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions.
Lung Neoplasms
Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions.
Lung Neoplasms
Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions.
Lung Neoplasms
Detection by denaturant gradient gel electrophoresis of tumor-specific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer.
Lung Neoplasms
Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
Lung Neoplasms
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Lung Neoplasms
Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.
Lung Neoplasms
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Lung Neoplasms
Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues.
Lung Neoplasms
Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.
Lung Neoplasms
Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis.
Lung Neoplasms
Detection of K-ras gene mutations in non-neoplastic lung tissue and lung cancers.
Lung Neoplasms
Detection of K-ras mutation in sputum by mutant-allele-specific amplification (MASA).
Lung Neoplasms
Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
Lung Neoplasms
Detection of K-ras mutations of bronchoalveolar lavage fluid cells aids the diagnosis of lung cancer in small pulmonary lesions.
Lung Neoplasms
Detection of K-ras oncogene mutations by polymerase chain reaction-based ligase chain reaction.
Lung Neoplasms
Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis.
Lung Neoplasms
Detection of k-ras point mutations in codons 12 and 13 in non-small cell lung cancers.
Lung Neoplasms
Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT.
Lung Neoplasms
Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
Lung Neoplasms
Detection of miR-155-5p and imaging lung cancer for early diagnosis: in vitro and in vivo study.
Lung Neoplasms
Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Lung Neoplasms
Detection of Point Mutations of K-ras Oncogene and p53 Tumor-Suppressor Gene in Sputum Samples.
Lung Neoplasms
Detection of serum factors enhancing cell mutability from lung cancer patients by application of hypermutable human RS cells.
Lung Neoplasms
Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
Lung Neoplasms
Diacylglycerol kinase ? modulates oncogenic properties of lung cancer cells.
Lung Neoplasms
Different site mutation of the K-ras gene in a patient with metachronous double lung cancers.
Lung Neoplasms
Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer.
Lung Neoplasms
Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers.
Lung Neoplasms
Differential response to 1?,25-dihydroxyvitamin D(3) (1?,25(OH)(2)D(3)) in non-small cell lung cancer cells with distinct oncogene mutations.
Lung Neoplasms
Distinctive evaluation of nonmucinous and mucinous subtypes of bronchioloalveolar carcinomas in EGFR and K-ras gene-mutation analyses for Japanese lung adenocarcinomas: confirmation of the correlations with histologic subtypes and gene mutations.
Lung Neoplasms
DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
Lung Neoplasms
Downregulation of miR-25 modulates non-small cell lung cancer cells by targeting CDC42.
Lung Neoplasms
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Lung Neoplasms
Dr. Neri et al.: Prognostic role of K-ras mutations in non-small cell lung cancer: Still an issue for open debate.
Lung Neoplasms
Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations.
Lung Neoplasms
Dual targeting of PI3K and MEK enhances the radiation response of K-RAS mutated non-small cell lung cancer.
Lung Neoplasms
Early recognition of lung cancer by integrin targeted imaging in K-ras mouse model.
Lung Neoplasms
Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression.
Lung Neoplasms
Effects of silencing Rab27a gene on biological characteristics and chemosensitivity of non-small cell lung cancer.
Lung Neoplasms
Efficacy of PHA-848125, a cyclin-dependent kinase inhibitor, on the K-Ras(G12D)LA2 lung adenocarcinoma transgenic mouse model: evaluation by multimodality imaging.
Lung Neoplasms
EGF-stimulated activation of Rab35 regulates RUSC2-GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration.
Lung Neoplasms
EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens.
Lung Neoplasms
EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non-small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy.
Lung Neoplasms
EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
Lung Neoplasms
Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.
Lung Neoplasms
Enhancement of lung carcinogenesis initiated with 4-(N-hydroxymethylnitrosamino)-1-(3-pyridyl)-1-butanone by Ogg1 gene deficiency in female, but not male, mice.
Lung Neoplasms
Enhancing therapeutic efficacy of the MEK inhibitor, MEK162, by blocking autophagy or inhibiting PI3K/Akt signaling in human lung cancer cells.
Lung Neoplasms
Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines.
Lung Neoplasms
Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors.
Lung Neoplasms
Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
Lung Neoplasms
Epigenetic regulation of TGF-?-induced EMT by JMJD3/KDM6B histone H3K27 demethylase.
Lung Neoplasms
Epithelial cell migration as a potential therapeutic target in early lung cancer.
Lung Neoplasms
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Lung Neoplasms
Erratum and apology re: "Detection of K-ras oncogene mutations in bronchoalveolar lavage fluid for lung cancer diagnosis".
Lung Neoplasms
Exosomal expression of RAB27A and its related lncRNA Lnc-RNA-RP11-510M2 in lung cancer.
Lung Neoplasms
Exosomes derived from Rab27a?overexpressing tumor cells elicit efficient induction of antitumor immunity.
Lung Neoplasms
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
Lung Neoplasms
Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
Lung Neoplasms
Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors.
Lung Neoplasms
Facilitated detection of oncogene mutations from exfoliated tissue material by a PNA-mediated 'enriched PCR' protocol.
Lung Neoplasms
FHIT and p53 gene abnormalities in bronchioloalveolar carcinomas. Correlations with clinicopathological data and K-ras mutations.
Lung Neoplasms
Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition.
Lung Neoplasms
Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer.
Lung Neoplasms
Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.)
Lung Neoplasms
Frequent detection of ras and p53 mutations in brush cytology samples from lung cancer patients by a restriction fragment length polymorphism-based "enriched PCR" technique.
Lung Neoplasms
Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.
Lung Neoplasms
Geminin functions downstream of p53 in K-ras-induced gene amplification of dihydrofolate reductase.
Lung Neoplasms
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Lung Neoplasms
Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells.
Lung Neoplasms
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.
Lung Neoplasms
Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT.
Lung Neoplasms
Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
Lung Neoplasms
Genetic evidence for an independent origin of multiple preneoplastic and neoplastic lung lesions.
Lung Neoplasms
Genetic factors in lung disease. Part II: Lung cancer and angiotensin converting enzyme gene.
Lung Neoplasms
Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.
Lung Neoplasms
Genomics of non-small cell lung cancer (NSCLC): Association between CT-based imaging features and EGFR and K-RAS mutations in 122 patients-An external validation.
Lung Neoplasms
Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
Lung Neoplasms
Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells.
Lung Neoplasms
Growth regulation via insulin-like growth factor binding protein-4 and -2 in association with mutant K-ras in lung epithelia.
Lung Neoplasms
GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
Lung Neoplasms
Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
Lung Neoplasms
Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mechanisms.
Lung Neoplasms
High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene.
Lung Neoplasms
High frequency of K-ras codon 12 mutations in bronchoalveolar lavage fluid of patients at high risk for second primary lung cancer.
Lung Neoplasms
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
Lung Neoplasms
High TUBB3 expression, an independent prognostic marker in patients with early non small cell lung cancer (NSCLC) treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.
Lung Neoplasms
Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.
Lung Neoplasms
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
Lung Neoplasms
Hypomethylation of CCGG sites in the 3' region of H-ras protooncogene is frequent and is associated with H-ras allele loss in non-small cell lung cancer.
Lung Neoplasms
Identification and imaging of miR-155 in the early screening of lung cancer by targeted delivery of octreotide-conjugated chitosan-molecular beacon nanoparticles.
Lung Neoplasms
Identification of a new inhibitor of KRAS-PDE? interaction targeting KRAS mutant non-small cell lung cancer.
Lung Neoplasms
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.
Lung Neoplasms
Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
Lung Neoplasms
Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
Lung Neoplasms
IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer.
Lung Neoplasms
Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma.
Lung Neoplasms
Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
Lung Neoplasms
Impact of smoking on frequency and spectrum of K-RAS and EGFR mutations in treatment naive Indonesian lung cancer patients.
Lung Neoplasms
Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
Lung Neoplasms
In Silico Screening of Mutated K-Ras Inhibitors from Malaysian Typhonium flagelliforme for Non-Small Cell Lung Cancer.
Lung Neoplasms
In vitro anti-tumor immune response induced by dendritic cells transfected with recombinant adenovirus carrying mutant K-ras genes.
Lung Neoplasms
In vitro study of farnesyltransferase inhibitor SCH 66336, in combination with chemotherapy and radiation, in non-small cell lung cancer cell lines.
Lung Neoplasms
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Lung Neoplasms
Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.
Lung Neoplasms
Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months.
Lung Neoplasms
Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice.
Lung Neoplasms
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.
Lung Neoplasms
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Lung Neoplasms
Inhibition of K-Ras4B-plasma membrane association with a membrane microdomain-targeting peptide.
Lung Neoplasms
Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-actiated protein kinase (MAPK) and phosphatidylinositol-3- kinase (PI3K)/AKT pathways.
Lung Neoplasms
Inhibition of oncogenic K-ras signaling by aerosolized gene delivery in a mouse model of human lung cancer.
Lung Neoplasms
Inhibitors Targeting CDK9 Show High Efficacy against Osimertinib and AMG510 Resistant Lung Adenocarcinoma Cells.
Lung Neoplasms
Interaction between smoking and asbestos in human lung adenocarcinoma: role of K-ras mutations.
Lung Neoplasms
Interaction between the bone morphogenetic proteins and Ras/MAP-kinase signalling pathways in lung cancer.
Lung Neoplasms
Interferon-? reduces the gefitinib sensitivity of human non-small cell lung cancer.
Lung Neoplasms
Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer.
Lung Neoplasms
Interplay between estrogen and Stat3/NF-?B-driven immunomodulation in lung cancer.
Lung Neoplasms
Is there a prognostic role of K-ras point mutations in the serum of patients with advanced non-small cell lung cancer?
Lung Neoplasms
Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
Lung Neoplasms
JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.
Lung Neoplasms
K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer.
Lung Neoplasms
K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
Lung Neoplasms
K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report.
Lung Neoplasms
K-ras gene mutation in sputum samples containing atypical cells and adenocarcinoma cells in the lung.
Lung Neoplasms
K-ras gene mutation is a useful predictor of the survival of early stage colorectal cancers.
Lung Neoplasms
K-ras gene point mutation in neogenetic lesions of subpleural fibrotic lesions: either an early genetic event in lung cancer development or a non-specific genetic change during the inflammatory reparative process.
Lung Neoplasms
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
Lung Neoplasms
k-RAS mutation and resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with nonsmall cell lung cancer.
Lung Neoplasms
K-ras mutation in sputum of primary lung cancer patients does not always reflect that of cancerous cells.
Lung Neoplasms
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
Lung Neoplasms
K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
Lung Neoplasms
K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
Lung Neoplasms
K-ras mutations in circulating DNA from pancreatic and lung cancers: bridging methodology for a common validation of the molecular diagnosis value.
Lung Neoplasms
K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
Lung Neoplasms
K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
Lung Neoplasms
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
Lung Neoplasms
k-RAS mutations in non-small cell lung cancer patients treated with TKIs among smokers and non-smokers: a meta-analysis.
Lung Neoplasms
K-Ras Mutations in Non-Small-Cell Lung Cancer: Prognostic and Predictive Value.
Lung Neoplasms
K-ras oncogene activation in atypical alveolar hyperplasias of the human lung.
Lung Neoplasms
K-ras oncogene mutation as a prognostic marker in non-small cell lung cancer: a combined analysis of 881 cases.
Lung Neoplasms
K-ras point mutation detection in lung cancer: comparison of two approaches to somatic mutation detection using ARMS allele-specific amplification.
Lung Neoplasms
K-ras point mutation occurs in the early stage of carcinogenesis in lung cancer.
Lung Neoplasms
K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation.
Lung Neoplasms
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
Lung Neoplasms
K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
Lung Neoplasms
Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells.
Lung Neoplasms
Knockdown of the sodium-dependent phosphate co-transporter 2b (NPT2b) suppresses lung tumorigenesis.
Lung Neoplasms
Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival.
Lung Neoplasms
Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy.
Lung Neoplasms
LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
Lung Neoplasms
Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice.
Lung Neoplasms
Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
Lung Neoplasms
LncRNA PCAT-1 upregulates RAP1A through modulating miR-324-5p and promotes survival in lung cancer.
Lung Neoplasms
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Lung Neoplasms
Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy.
Lung Neoplasms
Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Lung Neoplasms
Lovastatin overcomes gefitinib resistance in human non-small cell lung cancer cells with K-Ras mutations.
Lung Neoplasms
Low frequency of alterations in p53, K-ras, and mdm2 in rat lung neoplasms induced by diesel exhaust or carbon black.
Lung Neoplasms
Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
Lung Neoplasms
Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
Lung Neoplasms
Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
Lung Neoplasms
Lung cancer-associated SNP at the beginning of mouse k-ras gene intron 2 is essential for transcription factor binding.
Lung Neoplasms
Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea.
Lung Neoplasms
Luteolin attenuates migration and invasion of lung cancer cells via suppressing focal adhesion kinase and non-receptor tyrosine kinase signaling pathway.
Lung Neoplasms
MALT1 is required for EGFR-induced NF-?B activation and contributes to EGFR-driven lung cancer progression.
Lung Neoplasms
Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
Lung Neoplasms
Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
Lung Neoplasms
Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.
Lung Neoplasms
MicroRNA let-7a Inhibits the Proliferation and Invasion of Nonsmall Cell Lung Cancer Cell Line 95D by Regulating K-Ras and HMGA2 Gene Expression.
Lung Neoplasms
microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling.
Lung Neoplasms
microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction.
Lung Neoplasms
MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer.
Lung Neoplasms
MicroRNA-30b/c inhibits non-small cell lung cancer cell proliferation by targeting Rab18.
Lung Neoplasms
MiR-135a inhibits non-small cell lung cancer progression by suppressing RAB1B expression and the RAS pathway.
Lung Neoplasms
miR-137 inhibits the proliferation of lung cancer cells by targeting Cdc42 and Cdk6.
Lung Neoplasms
MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
Lung Neoplasms
miR-337-3p and its targets STAT3 and RAP1A modulate taxane sensitivity in non-small cell lung cancers.
Lung Neoplasms
MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
Lung Neoplasms
MiroRNA-188 Acts as Tumor Suppressor in Non-Small-Cell Lung Cancer by Targeting MAP3K3.
Lung Neoplasms
Mitochondrial catalase suppresses naturally occurring lung cancer in old mice.
Lung Neoplasms
Modification of mutant K-ras gene expression in non-small cell lung cancer (NSCLC).
Lung Neoplasms
Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.
Lung Neoplasms
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Lung Neoplasms
Molecular genetic tumor markers in the early diagnosis and screening of non-small-cell lung cancer.
Lung Neoplasms
Molecular margin analysis predicts local recurrence after sublobar resection of lung cancer.
Lung Neoplasms
Molecular staging of non-small cell lung cancer according to K-ras genotypes.
Lung Neoplasms
Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
Lung Neoplasms
Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.
Lung Neoplasms
Mucoepidermoid carcinoma of the lung, response to EGFR inhibitors, EGFR and K-RAS mutations, and differential diagnosis.
Lung Neoplasms
Multiple MicroRNAs synergistically promote tolerance to epidermal growth factor receptor-targeted drugs in smoked lung cancer therapies.
Lung Neoplasms
Mutant K-ras oncogenes in colon cancers Do not predict Patient's chemotherapy response or survival
Lung Neoplasms
Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
Lung Neoplasms
Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.
Lung Neoplasms
Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study.
Lung Neoplasms
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Lung Neoplasms
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Lung Neoplasms
Mutations in K-ras codon 12 detected in plasma DNA are not an indicator of disease in patients with non-small cell lung cancer.
Lung Neoplasms
Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
Lung Neoplasms
Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines.
Lung Neoplasms
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
Lung Neoplasms
Nanomedicine-Assisted Combination Therapy of NSCLC: New Platinum-Based Anticancer Drug Synergizes the Therapeutic Efficacy of Ganetespib.
Lung Neoplasms
New molecular approaches to lung cancer: biological and clinical implications of P53, P16 and K-RAS studies.
Lung Neoplasms
No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer.
Lung Neoplasms
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Lung Neoplasms
Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.
Lung Neoplasms
NTP Toxicology and Carcinogenesis Studies of Tetranitromethane (CAS No. 509-14-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
Lung Neoplasms
Oncogenes and Tumor Suppressor Genes in the Carcinogenicity of Fibers and Particles.
Lung Neoplasms
Oncogenic Activity of Ect2 Is Regulated through Protein Kinase C{iota}-mediated Phosphorylation.
Lung Neoplasms
Oncogenic K-ras confers SAHA resistance by up-regulating HDAC6 and c-myc expression.
Lung Neoplasms
Oncogenic K-Ras regulates proliferation and cell junctions in lung epithelial cells through induction of cyclooxygenase-2 and activation of metalloproteinase-9.
Lung Neoplasms
Oncogenic KRAS signaling and YAP1/?-catenin: Similar cell cycle control in tumor initiation.
Lung Neoplasms
Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation.
Lung Neoplasms
Origin and pharmacological modulation of tumor-associated regulatory dendritic cells.
Lung Neoplasms
Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancers.
Lung Neoplasms
Overexpression of small GTPases directly correlates with expression of ?-catenin and their coexpression predicts a poor clinical outcome in nonsmall cell lung cancer.
Lung Neoplasms
p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells.
Lung Neoplasms
p38? negatively regulates survival and malignant selection of transformed bronchioalveolar stem cells.
Lung Neoplasms
p53 Activation by Blocking Snail : A Novel Pharmacological Strategy for Cancer.
Lung Neoplasms
p53 and K-ras mutations in lung cancers from former and never-smoking women.
Lung Neoplasms
p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.
Lung Neoplasms
Partial suppression of tumorigenicity in a human lung cancer cell line transfected with Krev-1.
Lung Neoplasms
Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study.
Lung Neoplasms
PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
Lung Neoplasms
Personalized medicine and treatment approaches in non-small-cell lung carcinoma.
Lung Neoplasms
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
Lung Neoplasms
Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
Lung Neoplasms
PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
Lung Neoplasms
Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
Lung Neoplasms
Polyisoprenylated cysteinyl amide inhibitors deplete K-Ras and induce caspase-dependent apoptosis in lung cancer cells.
Lung Neoplasms
Predictive and Prognostic Biomarkers for Patients Treated with Anti-EGFR Agents in Lung Cancer: A Systemic Review and Meta-Analysis.
Lung Neoplasms
Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation.
Lung Neoplasms
Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis.
Lung Neoplasms
Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice.
Lung Neoplasms
Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.
Lung Neoplasms
PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells.
Lung Neoplasms
Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
Lung Neoplasms
Prognostic factors in resected stage I non-small-cell lung cancer: a multivariate analysis of six molecular markers.
Lung Neoplasms
Prognostic impact of mutated K-ras gene in surgically resected non-small cell lung cancer patients.
Lung Neoplasms
Prognostic role of K-Ras mutations in non-small cell lung cancer: still an issue for open debate.
Lung Neoplasms
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Lung Neoplasms
Prognostic significance of K-ras codon 12 mutations in patients with resected stage I and II non-small-cell lung cancer.
Lung Neoplasms
Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
Lung Neoplasms
Prognostic value of k-ras 12 genotypes in patients with advanced nonsmall cell lung-cancer receiving Carboplatin with either intravenous or chronic oral dose Etoposide.
Lung Neoplasms
Prognostic value of K-RAS mutations in patients with non-small cell lung cancer: a systematic review with meta-analysis.
Lung Neoplasms
Prolonged sulforaphane treatment does not enhance tumorigenesis in oncogenic K-ras and xenograft mouse models of lung cancer.
Lung Neoplasms
Promotion of Lung Carcinogenesis by COPD-like Airway Inflammation in a K-ras Induced Mouse Model.
Lung Neoplasms
Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
Lung Neoplasms
Prx I suppresses K-ras-driven lung tumorigenesis by opposing redox-sensitive ERK/cyclin D1 pathway.
Lung Neoplasms
Quantitative enriched PCR (QEPCR), a highly sensitive method for detection of K-ras oncogene mutation.
Lung Neoplasms
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
Lung Neoplasms
Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
Lung Neoplasms
RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
Lung Neoplasms
Rad GTPase inhibits the NF?B pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation.
Lung Neoplasms
Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes.
Lung Neoplasms
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Lung Neoplasms
Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.
Lung Neoplasms
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Lung Neoplasms
Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
Lung Neoplasms
Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer.
Lung Neoplasms
Regulatory single nucleotide polymorphisms at the beginning of intron 2 of the human KRAS gene.
Lung Neoplasms
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancer.
Lung Neoplasms
Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
Lung Neoplasms
Response to First-Line Chemotherapy in Patients With Non-Small-Cell Lung Cancer According to Epidermal Growth Factor Receptor and K-RAS Mutation Status.
Lung Neoplasms
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Lung Neoplasms
Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.
Lung Neoplasms
Rho GTPase Activating Protein 24 (ARHGAP24) Silencing Promotes Lung Cancer Cell Migration and Invasion by Activating ?-Catenin Signaling.
Lung Neoplasms
RHOB expression controls the activity of serine/threonine protein phosphatase PP2A to modulate mesenchymal phenotype and invasion in non-small cell lung cancers.
Lung Neoplasms
Risk assessment of space radiation-induced invasive cancer in mouse models of lung and colorectal cancer.
Lung Neoplasms
Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
Lung Neoplasms
Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
Lung Neoplasms
RRAD inhibits the Warburg effect through negative regulation of the NF-?B signaling.
Lung Neoplasms
Schedule-dependent apoptosis in K-ras mutant non-small-cell lung cancer cell lines treated with docetaxel and erlotinib: rationale for pharmacodynamic separation.
Lung Neoplasms
Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
Lung Neoplasms
Single-agent paclitaxel by 3-hour infusion in the treatment of non-small cell lung cancer: links between p53 and K-ras gene status and chemosensitivity.
Lung Neoplasms
siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer.
Lung Neoplasms
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice.
Lung Neoplasms
Sorafenib in patients with advanced non-small cell lung cancer that harbor K-ras mutations: a brief report.
Lung Neoplasms
Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA.
Lung Neoplasms
Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy.
Lung Neoplasms
Studies on clinicopathological features of lung cancer patients with K-ras/p53 gene alterations: comparison between younger and older groups.
Lung Neoplasms
Sublocalization of Rab23, a mediator of Sonic hedgehog signaling pathway, in hepatocellular carcinoma cell lines.
Lung Neoplasms
Suppression of A549 lung cancer cell migration by precursor let-7g microRNA.
Lung Neoplasms
Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA.
Lung Neoplasms
Suppression of lung cancer tumor growth in a nude mouse model by the Ras inhibitor salirasib (farnesylthiosalicylic acid).
Lung Neoplasms
Suppression of non-small cell lung tumor development by the let-7 microRNA family.
Lung Neoplasms
Synchronous double primary lung cancers via p53 pathway induced by heavy smoking.
Lung Neoplasms
Synergistic cell growth inhibition by the combination of amrubicin and Akt-suppressing agents in K-ras mutation-harboring lung adenocarcinoma cells: implication of EGFR tyrosine kinase inhibitors.
Lung Neoplasms
Synergistic effects of sorafenib in combination with gemcitabine or pemetrexed in lung cancer cell lines with K-ras mutations.
Lung Neoplasms
TBK1 kinase addiction in lung cancer cells is mediated via autophagy of Tax1bp1/Ndp52 and non-canonical NF-?B signalling.
Lung Neoplasms
Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer.
Lung Neoplasms
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
Lung Neoplasms
The Extract of Cordyceps Militaris Inhibited the Proliferation of Cisplatin-Resistant A549 Lung Cancer Cells by Downregulation of H-Ras.
Lung Neoplasms
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
Lung Neoplasms
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice.
Lung Neoplasms
The lichen secondary metabolite atranorin suppresses lung cancer cell motility and tumorigenesis.
Lung Neoplasms
The presence of Merkel cell polyomavirus is associated with deregulated expression of BRAF and Bcl-2 genes in non-small cell lung cancer.
Lung Neoplasms
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
Lung Neoplasms
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Lung Neoplasms
The role of K-Ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.
Lung Neoplasms
The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status.
Lung Neoplasms
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
Lung Neoplasms
Therapeutic Efficacy of Lactonic Sophorolipids: Nanoceria-Assisted Combination Therapy of NSCLC using HDAC and Hsp90 Inhibitors.
Lung Neoplasms
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Lung Neoplasms
Toxicology and Carcinogenesis Studies of Cumene (CAS No. 98-82-8) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).
Lung Neoplasms
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
Lung Neoplasms
Type of TP53 mutation influences oncogenic potential and spectrum of associated K-ras mutations in lung-specific transgenic mice.
Lung Neoplasms
Understanding and re-engineering nucleoprotein machines to cure human disease.
Lung Neoplasms
Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.
Lung Neoplasms
Urine Proteome Profiling Predicts Lung Cancer from Control Cases and Other Tumors.
Lung Neoplasms
Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment.
Lung Neoplasms
Use of molecular markers for predicting therapy response in cancer patients.
Lung Neoplasms
VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Lung Neoplasms
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Lung Neoplasms
Vascular endothelial growth factor and other biological predictors related to the postoperative survival rate on non-small cell lung cancer.
Lung Neoplasms
VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations.
Lung Neoplasms
Vimentin regulates lung cancer cell adhesion through a VAV2-Rac1 pathway to control focal adhesion kinase activity.
Lung Neoplasms
[A new cell line derived from a nude mouse resembling human large cell lung cancer]
Lung Neoplasms
[Ablation of p120-Catenin Altering the Activity of Small GTPase in Human Lung Cancer Cells.]
Lung Neoplasms
[Analysis of oncogenes and suppressor genes in lung cancer and bronchial lesions from high risk group]
Lung Neoplasms
[Construction of let-7a expression plasmid and its inhibitory effect on k-Ras protein in A549 lung cancer cells].
Lung Neoplasms
[Correlation of expression of p120ctn , RhoA and Cdc42 and their significance in non-small cell lung cancer.]
Lung Neoplasms
[Detection of EGFR and K-ras mutations in non-small cell lung cancer using cytological specimens].
Lung Neoplasms
[Detection of K-ras mutation from malignant cells in sputum with mutant-allele specific amplification (MASA) method]
Lung Neoplasms
[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
Lung Neoplasms
[Detection of K-ras oncogene mutations in human lung cancer by PCR-SSCP-DNA direct sequencing]
Lung Neoplasms
[Detection of oncogenic mutations in sputum and its diagnostic value of lung cancer]
Lung Neoplasms
[Detection of P53 and K-ras gene mutations in lung cancer with oligonucleotide chip]
Lung Neoplasms
[Enhanced growth inhibition by combined two pathway inhibitors on K-ras mutated non-small cell lung cancer cells].
Lung Neoplasms
[Erratum: Identification Analysis of Eukaryotic Expression Plasmid Rap2a and Its Effect on the Migration of Lung Cancer Cells].
Lung Neoplasms
[Establishment and its biological characteristics of patient-derived lung cancer xenograft models]
Lung Neoplasms
[Expression and clinical significance of caspase-3,survivin and k-ras in non-small cell lung cancer.]
Lung Neoplasms
[Expression of surviving gene and its relationship with expression of P53, c-myc, k-ras proteins in non-small-cell lung cancer]
Lung Neoplasms
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
Lung Neoplasms
[Identification analysis of eukaryotic expression plasmid Rap2a and its effect on the migration of lung cancer cells].
Lung Neoplasms
[K-ras gene mutations of asbestos and welding-fumes related human lung cancer]
Lung Neoplasms
[K-ras mutation predictive significance in platinum based chemotherapeutic protocols in patients with advanced non-small cell lung cancer]
Lung Neoplasms
[Mutational analysis of EGFR and K-RAS in Chinese patients with non-small cell lung cancer]
Lung Neoplasms
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
Lung Neoplasms
[Relationship between the protein expression of ERCC1, BRCA, ?-tubulin and K-ras and the efficacy and prognosis in advanced non-small cell lung cancer].
Lung Neoplasms
[Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
Lung Neoplasms
[Reversal of pulmonary hypertrophic osteoarthropathy in surgically treated lung cancer].
Lung Neoplasms
[Screening for K-ras mutations in colorectal and lung cancers by using a novel real-time PCR with ADx-K-ras kit and Sanger DNA sequencing].
Lung Neoplasms
[Study of 8-OH-dG and its correlation with several cancer related gene in lung cancer tissues]
Lung Neoplasms
[Study of growth inhibition of lung cancer cells by siRNA targeting mutant K-ras gene in vitro and in vivo]
Lung Neoplasms
[Study on point mutations of K-ras gene in non-small cell lung cancer in Guangxi].
Lung Neoplasms
[Study on the mutations of p53 and K-ras gene in the cancer tissues and sputum cells of patients with lung cancer.]
Lung Neoplasms
[Synchronous Multiple Primary Lung Cancer Dignosed ?by Different Phenotype-genotype: A Case Report and Literature Review].
Lung Neoplasms
[The Expression of COX-2 in Human Lung Cancer and its Relationship with Expression of K-ras and Mcl-1.]
Lung Neoplasms
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
Lung Neoplasms
[The relationship between smoking and p53 and Ki-ras gene mutations in sputum cells of patients with lung cancer.]
Lung Neoplasms
[The role of the constitutional features and rearrangement of the H-ras 1 oncogene in the development of human lung cancer]
Lung Neoplasms
[The study of correlation between the K-ras genotype and murine susceptibility to chemically induced lung neoplasms]
Lupus Erythematosus, Systemic
Signal transduction pathways in chronic inflammatory autoimmune disease: small GTPases.
Lyme Disease
Borrelia burgdorferi elongation factor EF-Tu is an immunogenic protein during Lyme borreliosis.
Lymphatic Metastasis
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Lymphatic Metastasis
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Lymphatic Metastasis
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Lymphatic Metastasis
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Lymphatic Metastasis
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Lymphatic Metastasis
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Lymphatic Metastasis
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
Lymphatic Metastasis
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
Lymphatic Metastasis
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Lymphatic Metastasis
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Lymphatic Metastasis
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Lymphatic Metastasis
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Lymphatic Metastasis
ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.
Lymphatic Metastasis
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
Lymphatic Metastasis
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Lymphatic Metastasis
Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.
Lymphatic Metastasis
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Lymphatic Metastasis
Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
Lymphatic Metastasis
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Lymphatic Metastasis
Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
Lymphatic Metastasis
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
Lymphatic Metastasis
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Lymphatic Metastasis
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
Lymphatic Metastasis
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
Lymphatic Metastasis
Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
Lymphatic Metastasis
Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer.
Lymphatic Metastasis
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Lymphatic Metastasis
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
Lymphatic Metastasis
Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
Lymphatic Metastasis
Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis.
Lymphatic Metastasis
Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.
Lymphatic Metastasis
Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis.
Lymphatic Metastasis
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Lymphatic Metastasis
Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Lymphatic Metastasis
Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
Lymphatic Metastasis
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications.
Lymphatic Metastasis
Re. article entitled 'Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations'.
Lymphatic Metastasis
The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study.
Lymphatic Metastasis
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Lymphatic Metastasis
The secretory small GTPase Rab27B as a marker for breast cancer progression.
Lymphatic Metastasis
[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer]
Lymphatic Metastasis
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
Lymphocytic Choriomeningitis
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Lymphohistiocytosis, Hemophagocytic
A Griscelli syndrome type 2 murine model of hemophagocytic lymphohistiocytosis (HLH).
Lymphohistiocytosis, Hemophagocytic
A Heterozygous RAB27A Mutation Associated with Delayed Cytolytic Granule Polarization and Hemophagocytic Lymphohistiocytosis.
Lymphohistiocytosis, Hemophagocytic
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
Lymphohistiocytosis, Hemophagocytic
A RAB27A 5'UTR structural variant associated with late-onset hemophagocytic lymphohistiocytosis and normal pigmentation.
Lymphohistiocytosis, Hemophagocytic
Different NK cell activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity.
Lymphohistiocytosis, Hemophagocytic
Evidence for defective Rab GTPase-dependent cargo traffic in immune disorders.
Lymphohistiocytosis, Hemophagocytic
Evidence that Griscelli syndrome with neurological involvement is caused by mutations in RAB27A, not MYO5A.
Lymphohistiocytosis, Hemophagocytic
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis.
Lymphohistiocytosis, Hemophagocytic
Griscelli syndrome: report of the first peripheral blood stem cell transplant and the role of mutations in the RAB27A gene as an indication for BMT.
Lymphohistiocytosis, Hemophagocytic
Hematopoietic stem cell transplantation in children with Griscelli Syndrome type 2: Experience and outcomes.
Lymphohistiocytosis, Hemophagocytic
Hemophagocytic lymphohistiocytosis and related disorders.
Lymphohistiocytosis, Hemophagocytic
MUNC13-4 protein regulates the oxidative response and is essential for phagosomal maturation and bacterial killing in neutrophils.
Lymphohistiocytosis, Hemophagocytic
Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A.
Lymphohistiocytosis, Hemophagocytic
NK cytotoxicity mediated by CD16 but not by NKp30 is functional in Griscelli syndrome.
Lymphohistiocytosis, Hemophagocytic
Oral features of Griscelli syndrome type II: A rare case report.
Lymphohistiocytosis, Hemophagocytic
Pulmonary lymphomatoid granulomatosis in Griscelli syndrome type 2.
Lymphohistiocytosis, Hemophagocytic
Rab27a negatively regulates phagocytosis by prolongation of the actin-coating stage around phagosomes.
Lymphohistiocytosis, Hemophagocytic
Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
Lymphohistiocytosis, Hemophagocytic
The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane.
Lymphohistiocytosis, Hemophagocytic
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Lymphohistiocytosis, Hemophagocytic
[Defect in lytic granule exocytosis : several causes, a same effect.]
Lymphoma
A unique carboxyl-terminal insert domain in the hematopoietic-specific, GTPase-deficient Rho GTPase RhoH regulates post-translational processing.
Lymphoma
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.
Lymphoma
Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.
Lymphoma
Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice.
Lymphoma
An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis.
Lymphoma
Analysis of p53, K-ras, c-kit, and beta-catenin gene mutations in sinonasal NK/T cell lymphoma in northeast district of China.
Lymphoma
Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.
Lymphoma
Characteristic association between K-ras gene mutation with loss of heterozygosity in X-ray-induced thymic lymphomas of the B6C3F1 mouse.
Lymphoma
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
Lymphoma
Cooperative alterations of Rb pathway regulators in mouse primary T cell lymphomas.
Lymphoma
Degradation of Tiam1 by casein kinase 1 and the SCF?TrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.
Lymphoma
Differential expression of the normal and mutated K-ras alleles in chemically induced thymic lymphomas.
Lymphoma
Exosomes secreted from cancer-associated fibroblasts elicit anti-pyrimidine drug resistance through modulation of its transporter in malignant lymphoma.
Lymphoma
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
Lymphoma
Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.
Lymphoma
Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients.
Lymphoma
Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea.
Lymphoma
Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability.
Lymphoma
Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
Lymphoma
Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas.
Lymphoma
Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.
Lymphoma
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Lymphoma
Mice over-expressing human O6 alkylguanine-DNA alkyltransferase selectively reduce O6 methylguanine mediated carcinogenic mutations to threshold levels after N-methyl-N-nitrosourea.
Lymphoma
Molecular profiling to optimize treatment in non-small cell lung cancer: a review of potential molecular targets for radiation therapy by the translational research program of the radiation therapy oncology group.
Lymphoma
Mutations of p53, c-kit, K-ras, and beta-catenin gene in non-Hodgkin's lymphoma of adrenal gland.
Lymphoma
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years.
Lymphoma
p53, K-ras, c-kit and beta-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.
Lymphoma
P53, N- and K-Ras, and beta-catenin gene mutations and prognostic factors in nasal NK/T-cell lymphoma from Hokkaido, Japan.
Lymphoma
Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase.
Lymphoma
ras oncogenes and phenotypic staging in N-methylnitrosourea- and gamma-irradiation-induced thymic lymphomas in C57BL/6J mice.
Lymphoma
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Lymphoma
Recurrent intragenic exon rearrangements of SOBP and AUTS2 in non-Hodgkin B-cell lymphoma.
Lymphoma
Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
Lymphoma
Sialylation and glycosylation modulate cell adhesion and invasion to extracellular matrix in human malignant lymphoma: Dependency on integrin and the Rho GTPase family.
Lymphoma
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
Lymphoma
The Influence of Biomarker Mutations and Systemic Treatment on Cerebral Metastases from NSCLC Treated with Radiosurgery.
Lymphoma
The utility of cytology in the diagnosis of adenocarcinoma lung: A tertiary care center study.
Lymphoma
Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis.
Lymphoma
Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma.
Lymphoma
Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.
Lymphoma, B-Cell
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Lymphoma, B-Cell
Expression of miR-34a and miR-15b during the progression of cervical cancer in a murine model expressing the HPV16 E7 oncoprotein.
Lymphoma, B-Cell
p53 expression, K-ras gene mutation and microsatellite instability in gastric B-cell lymphomas.
Lymphoma, B-Cell
Recurrent intragenic exon rearrangements of SOBP and AUTS2 in non-Hodgkin B-cell lymphoma.
Lymphoma, B-Cell
Upregulated TRIO expression correlates with a malignant phenotype in human hepatocellular carcinoma.
Lymphoma, B-Cell, Marginal Zone
Helicobacter pylori eradication therapy for high-grade mucosa-associated lymphoid tissue lymphomas of the stomach with analysis of p53 and K-ras alteration and microsatellite instability.
Lymphoma, Large B-Cell, Diffuse
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Lymphoma, Large-Cell, Anaplastic
Inhibition of Rac controls NPM-ALK-dependent lymphoma development and dissemination.
Lymphoma, Large-Cell, Anaplastic
Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
Lymphoma, Large-Cell, Anaplastic
The anaplastic lymphoma kinase controls cell shape and growth of anaplastic large cell lymphoma through Cdc42 activation.
Lymphoma, Non-Hodgkin
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Association between C-myc and K-ras gene polymorphisms and non-Hodgkin lymphoma.
Lymphoma, Non-Hodgkin
Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
Lymphoma, Non-Hodgkin
H-RAS 1 minisatellite rare alleles: a genetic susceptibility and prognostic factor for non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Mutations of p53, c-kit, K-ras, and beta-catenin gene in non-Hodgkin's lymphoma of adrenal gland.
Lymphoma, T-Cell
Dasatinib is an effective treatment for angioimmunoblastic T-cell lymphoma.
Lymphoma, T-Cell
Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
Lymphoma, T-Cell
Roles of GTP and Rho GTPases in pancreatic islet beta cell function and dysfunction.
Lymphoma, T-Cell
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Lymphoma, T-Cell, Peripheral
Gene mutations in lymphoproliferative disorders of T and NK/T cell phenotypes developing in renal transplant patients.
Machado-Joseph Disease
cDNA cloning and tissue expression analyses of the encoding regions for three novel porcine genes- MJD1, CDC42 and NECD.
Macular Degeneration
CCL24 contributes to HCC malignancy via RhoB- VEGFA-VEGFR2 angiogenesis pathway and indicates poor prognosis.
Macular Degeneration
cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association.
Malaria
Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression.
Malaria
Structures of PI4KIII? complexes show simultaneous recruitment of Rab11 and its effectors.
Megalencephaly
Cerebral organoid and mouse models reveal a RAB39b-PI3K-mTOR pathway-dependent dysregulation of cortical development leading to macrocephaly/autism phenotypes.
Megalencephaly
Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
Megalencephaly
Recurrent ?100 Kb microdeletion in the chromosomal region 14q11.2, involving CHD8 gene, is associated with autism and macrocephaly.
Melanoma
5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.
Melanoma
A comprehensive genome-wide analysis of melanoma Breslow thickness identifies interaction between CDC42 and SCIN genetic variants.
Melanoma
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
Melanoma
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis.
Melanoma
Absence of ras gene mutations in UV-induced malignant melanomas correlates with a dermal origin of melanocytes in Monodelphis domestica.
Melanoma
Activation of small GTPase Rho is required for autocrine motility factor signaling.
Melanoma
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
Melanoma
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Melanoma
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
Melanoma
beta-catenin mutations are absent in hepatocellular carcinomas of SV40 T-antigen transgenic mice.
Melanoma
Binimetinib in heavily pretreated NRAS-mutant Melanoma Patients with Brain Metastases.
Melanoma
Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis.
Melanoma
Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells.
Melanoma
Circ_0013359 facilitates the tumorigenicity of melanoma by regulating miR-136-5p/RAB9A axis.
Melanoma
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
Melanoma
Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture.
Melanoma
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Melanoma
Exoenzyme C3 transferase lowers actin cytoskeleton dynamics, genomic stability and survival of malignant melanoma cells under UV-light stress.
Melanoma
Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma.
Melanoma
Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.
Melanoma
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging.
Melanoma
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.
Melanoma
Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma.
Melanoma
LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma.
Melanoma
Long non-coding RNA NEAT1 promotes tumor development and metastasis through targeting RAB9A in malignant melanoma.
Melanoma
Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B.
Melanoma
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis.
Melanoma
Long noncoding RNA ZFAS1 promotes tumorigenesis through regulation of miR-150-5p/RAB9A in melanoma.
Melanoma
Low level electricity increases the secretion of extracellular vesicles from cultured cells.
Melanoma
Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
Melanoma
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Melanoma
Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport.
Melanoma
Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets.
Melanoma
NecroX-5 Can Suppress Melanoma Metastasis by Reducing the Expression of Rho-Family GTPases.
Melanoma
Neratinib and entinostat combine to rapidly reduce the expression of K-RAS, N-RAS, G?q and G?11 and kill uveal melanoma cells.
Melanoma
Non-canonical EphA2 signaling is a driver of tumor-endothelial cell interactions and metastatic dissemination in BRAF inhibitor resistant melanoma.
Melanoma
Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo.
Melanoma
Pentoxifylline impedes migration in B16F10 melanoma by modulating Rho GTPase activity and actin organisation.
Melanoma
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS).
Melanoma
Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells.
Melanoma
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
Melanoma
RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.
Melanoma
ras mutations in human melanotic lesions: K-ras activation is a frequent and early event in melanoma development.
Melanoma
Ras oncoproteins transfer from melanoma cells to T cells and modulate their effector functions.
Melanoma
RNAi-mediated knockdown of protein kinase C-alpha inhibits cell migration in MM-RU human metastatic melanoma cell line.
Melanoma
Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library.
Melanoma
Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.
Melanoma
Stromal cell-derived factor-1alpha promotes melanoma cell invasion across basement membranes involving stimulation of membrane-type 1 matrix metalloproteinase and Rho GTPase activities.
Melanoma
Structure based drug discovery of Rab38 protein- Identification of antagonists as cancer drug candidates.
Melanoma
Suppression of the malignant phenotype of melanoma cells by anti-oncogene ribozymes.
Melanoma
TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region.
Melanoma
The Antitumor Effect of Lipophilic Bisphosphonate BPH1222 in Melanoma Models: The Role of the PI3K/Akt Pathway and the Small G Protein Rheb.
Melanoma
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Melanoma
The Small GTPase ARF6 Stimulates ?-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis.
Melanoma
Tissue-specific expression of an anti-ras ribozyme inhibits proliferation of human malignant melanoma cells.
Melanoma, Amelanotic
Spontaneous uveal amelanotic melanoma in transgenic Tyr-RAS+ Ink4a/Arf-/- mice.
Melanoma, Experimental
Evidence that the small GTPase Rab8 is involved in melanosome traffic and dendrite extension in B16 melanoma cells.
Melanoma, Experimental
Inhibition of B16 melanoma cell proliferation and alterations in p21 ras expression induced by interceptors of signal transduction pathways.
Melanoma, Experimental
RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.
Melanoma, Experimental
The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.
Melioidosis
Immunospecific responses to bacterial elongation factor Tu during Burkholderia infection and immunization.
Memory Disorders
Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.
Memory Disorders
Upregulation of miR-137 protects anesthesia-induced hippocampal neurodegeneration.
Meningioma
Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.
Meningitis
CSF Levels of Elongation Factor Tu Is Associated With Increased Mortality in Malawian Adults With Streptococcus pneumoniae Meningitis.
Meningitis, Cryptococcal
Cryptococcus neoformans activates RhoGTPases followed by PKC, FAK and ezrin to enhance traversal across the blood-brain barrier.
Meningomyelocele
Amniotic fluid transcriptomics reflects novel disease mechanisms in fetuses with myelomeningocele.
Mental Retardation, X-Linked
Evidence that a major site of expression of the RHO-GTPASE activating protein, oligophrenin-1, is peripheral myelin.
Mental Retardation, X-Linked
Mutations in the small GTPase gene RAB39B are responsible for X-linked mental retardation associated with autism, epilepsy, and macrocephaly.
Mental Retardation, X-Linked
[Anassociation study between OPHN1 gene rs492933 polymorphism and mental retardation in children of the Qinba Mountain region.]
Mesothelioma
Analysis of K-ras and p53 mutations in mesotheliomas from humans and rats exposed to asbestos.
Mesothelioma
Bisphosphonates inhibit the growth of mesothelioma cells in vitro and in vivo.
Mesothelioma
Differential effects of Ca(2+) on bisphosphonate-induced growth inhibition in breast cancer and mesothelioma cells.
Mesothelioma
Molecular biology studies on mesothelioma tumor samples: preliminary data on H-ras, p21, and SV40.
Mesothelioma
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Mesothelioma, Malignant
Immunohistochemical staining of ras oncogene product in neoplastic and non-neoplastic mesothelial tissues: immunoreactivity for N-ras and lack of immunohistochemical staining for Ha-ras and K-ras.
Mesothelioma, Malignant
Molecular biology studies on mesothelioma tumor samples: preliminary data on H-ras, p21, and SV40.
Mesothelioma, Malignant
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Metabolic Syndrome
Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.
Metabolic Syndrome
Opposing roles of nitric oxide and rho-kinase in lipid metabolism in mice.
Microcephaly
Rab18 Collaborates with Rab7 to Modulate Lysosomal and Autophagy Activities in the Nervous System: an Overlapping Mechanism for Warburg Micro Syndrome and Charcot-Marie-Tooth Neuropathy Type 2B.
Microphthalmos
Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.
Motor Neuron Disease
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.
Mouth Neoplasms
Detection of a rare point mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer.
Mouth Neoplasms
Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer.
Mouth Neoplasms
H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
Mouth Neoplasms
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Mouth Neoplasms
High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.
Mouth Neoplasms
Influence of single nucleotide polymorphisms in H-Ras and cyclin D1 genes on oral cancer susceptibility.
Mouth Neoplasms
Mucosal HPV E6/E7 Peptide Vaccination in Combination with Immune Checkpoint Modulation Induces Regression of HPV+ Oral Cancers.
Mouth Neoplasms
Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3.
Mouth Neoplasms
S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Mouth Neoplasms
Understanding and re-engineering nucleoprotein machines to cure human disease.
Mouth Neoplasms
Urinary-type plasminogen activator receptor (uPAR) modulates oral cancer cell behavior with alteration in p130cas.
Multiple Myeloma
A single-chain Fv diabody against human leukocyte antigen-A molecules specifically induces myeloma cell death in the bone marrow environment.
Multiple Myeloma
Activating mutations in the N- and K-ras oncogenes differentially affect the growth properties of the IL-6-dependent myeloma cell line ANBL6.
Multiple Myeloma
Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial.
Multiple Myeloma
An unusual H-Ras mutant isolated from a human multiple myeloma line leads to transformation and factor-independent cell growth.
Multiple Myeloma
Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
Multiple Myeloma
Correlated flow cytometric analysis of H-ras p21 and nuclear DNA in multiple myeloma.
Multiple Myeloma
Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation.
Multiple Myeloma
High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis.
Multiple Myeloma
Histone deacetylase inhibition in combination with MEK or BCL-2 inhibition in multiple myeloma.
Multiple Myeloma
Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma.
Multiple Myeloma
Morphoproteomic expression of H-ras (p21ras) correlates with serum monoclonal immunoglobulin reduction in multiple myeloma patients following pamidronate treatment.
Multiple Myeloma
N-RAS and K-RAS gene mutations in Brazilian patients with multiple myeloma.
Multiple Myeloma
Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase.
Multiple Myeloma
Proliferation of IL-6-independent multiple myeloma does not require the activity of extracellular signal-regulated kinases (ERK1/2).
Multiple Myeloma
Rational Targeting of Cdc42 Overcomes Drug Resistance of Multiple Myeloma.
Multiple Myeloma
Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation.
Multiple Myeloma
The proliferation of multiple myeloma colonies (MY-CFUc) in vitro is independent of prognosis and is not associated with mutated N- or K-ras alleles in human bone marrow aspirates.
Multiple Myeloma
The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells.
Multiple Myeloma
The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma.
Multiple Myeloma
[Application of flow cytometry to the study of hematologic disorders: analysis of oncogene products]
Multiple Sclerosis
Expression of a T39N mutant Rab32 protein arrests mitochondria movement within neurites of differentiated SH-SY5Y cells.
Multiple Sclerosis
Small GTPase RAS in multiple sclerosis - exploring the role of RAS GTPase in the etiology of multiple sclerosis.
Multiple System Atrophy
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Multiple System Atrophy
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Muscle Hypotonia
Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.
Muscular Atrophy
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Muscular Atrophy
Dystrophin-glycoprotein complex and Ras and Rho GTPase signaling are altered in muscle atrophy.
Muscular Diseases
Statins and skeletal muscles toxicity: from clinical trials to everyday practice.
Muscular Dystrophy, Duchenne
The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation.
Mycoplasma Infections
High-level expression of H-ras and c-myc oncogenes in mycoplasma-mediated malignant cell transformation.
Mycoses
CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity.
Mycosis Fungoides
Altered expression of Bcl-2, c-Myc, H-Ras, K-Ras, and N-Ras does not influence the course of mycosis fungoides.
Myelodysplastic Syndromes
Multiple point mutation of N-ras and K-ras oncogenes in myelodysplastic syndrome and acute myelogenous leukemia.
Myelodysplastic Syndromes
Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes.
Myelodysplastic Syndromes
Prognostic importance of mutations in the ras proto-oncogenes in de novo acute myeloid leukemia.
Myelodysplastic Syndromes
Transforming genes and chromosome aberrations in therapy-related leukemia and myelodysplastic syndrome.
Myeloproliferative Disorders
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease.
Myeloproliferative Disorders
Nf1 deficiency co-operates with oncogenic K-RAS to induce acute myeloid leukemia in mice.
Myeloproliferative Disorders
The human GFI136N variant induces epigenetic changes at the Hoxa9 locus and accelerates K-RAS driven myeloproliferative disorder in mice.
Myocardial Infarction
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Myocardial Infarction
CREG ameliorates the phenotypic switching of cardiac fibroblasts after myocardial infarction via modulation of CDC42.
Myocardial Infarction
Expression and Activity of the Small RhoGTPase Cdc42 in Blood Cells of Older Adults Are Associated With Age and Cardiovascular Disease.
Myocardial Infarction
Interaction of small G protein signaling modulator 3 with connexin 43 contributes to myocardial infarction in rat hearts.
Myocardial Infarction
Rab27a deletion impairs the therapeutic potential of endothelial progenitor cells for myocardial infarction.
Myocardial Infarction
Small G protein signaling modulator 3 (SGSM3) knockdown attenuates apoptosis and cardiogenic differentiation in rat mesenchymal stem cells exposed to hypoxia.
Myocardial Infarction
[Establishment of a novel therapeutic strategy for heart failure based on the mechanism underlying maintenance of redox homeostasis by reactive sulfur species].
Myocarditis
Overexpression of microRNA-133b reduces myocardial injuries in children with viral myocarditis by targeting Rab27B gene.
Myotonic Dystrophy
Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
Myotonic Dystrophy
Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation.
Myotonic Dystrophy
Characterization of the Interaction of Phorbol Esters with the C1 Domain of MRCK (Myotonic Dystrophy Kinase-related Cdc42 Binding Kinase) {alpha}/{beta}
Myotonic Dystrophy
DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction.
Myotonic Dystrophy
Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3.
Myotonic Dystrophy
Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding.
Myotonic Dystrophy
Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour.
Myotonic Dystrophy
Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization.
Myotonic Dystrophy
Myotonic dystrophy kinase-related Cdc42-binding kinases (MRCK), the ROCK-like effectors of Cdc42 and Rac1.
Myotonic Dystrophy
Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton.
Myotonic Dystrophy
The myotonic dystrophy kinase-related Cdc42-binding kinase is involved in the regulation of neurite outgrowth in PC12 cells.
Nasopharyngeal Carcinoma
Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.
Nasopharyngeal Carcinoma
Knockdown Rab11-FIP2 inhibits migration and invasion of nasopharyngeal carcinoma via suppressing Rho GTPase signaling.
Nasopharyngeal Carcinoma
Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
MicroRNA?342?3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.
Nasopharyngeal Carcinoma
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma.
Nasopharyngeal Carcinoma
One-dimensional microfluidic beads array for multiple mRNAs expression detection.
Nasopharyngeal Carcinoma
RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
Nasopharyngeal Carcinoma
The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area.
Nasopharyngeal Carcinoma
[Effects of silencing H-ras gene by RNA interference on cetuximab-sensitivity of cetuximab-resistant human nasopharyngeal carcinoma cells].
Nasopharyngeal Neoplasms
MiR-20a-5p promotes radio-resistance by targeting Rab27B in nasopharyngeal cancer cells.
Neoplasm Metastasis
?-Adrenergic receptors suppress Rap1B prenylation and promote the metastatic phenotype in breast cancer cells.
Neoplasm Metastasis
?-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases.
Neoplasm Metastasis
?Np63? suppresses cells invasion by downregulating PKC?/Rac1 signaling through miR-320a.
Neoplasm Metastasis
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Neoplasm Metastasis
A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression.
Neoplasm Metastasis
A polysaccharide from Pinellia ternata inhibits cell proliferation and metastasis in human cholangiocarcinoma cells by targeting of Cdc42 and 67kDa Laminin Receptor (LR).
Neoplasm Metastasis
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis.
Neoplasm Metastasis
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms.
Neoplasm Metastasis
Ablation of p120-catenin enhances invasion and metastasis of human lung cancer cells.
Neoplasm Metastasis
Abnormal expression of Rap2A as a prognostic marker for human breast cancer.
Neoplasm Metastasis
Abrogation of RAB27A expression transiently affects melanoma cell proliferation.
Neoplasm Metastasis
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-?B signaling pathways.
Neoplasm Metastasis
Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma.
Neoplasm Metastasis
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
Neoplasm Metastasis
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo.
Neoplasm Metastasis
AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.
Neoplasm Metastasis
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Neoplasm Metastasis
Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection.
Neoplasm Metastasis
Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness.
Neoplasm Metastasis
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Neoplasm Metastasis
Analysis of gp74 expression by transformed rat fibroblasts from experimental pulmonary metastases following specific ricin A-chain immunotoxin therapy.
Neoplasm Metastasis
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Neoplasm Metastasis
Analysis of microsatellite instability, K-ras gene mutation and p53 protein overexpression in intrahepatic cholangiocarcinoma.
Neoplasm Metastasis
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
Neoplasm Metastasis
Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods.
Neoplasm Metastasis
Angiogenesis and p53 and H-ras mutations in pancreatic ductal adenocarcinoma.
Neoplasm Metastasis
Anti-metastasis effects of gallic acid on gastric cancer cells involves inhibition of NF-kappaB activity and downregulation of PI3K/AKT/small GTPase signals.
Neoplasm Metastasis
APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
Neoplasm Metastasis
Application of clonal analysis. Differential diagnosis for synchronous primary ovarian and endometrial cancers and metastatic cancer.
Neoplasm Metastasis
Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
Neoplasm Metastasis
Artemisinin inhibits in vitro and in vivo invasion and metastasis of human hepatocellular carcinoma cells.
Neoplasm Metastasis
Assessment of K-ras, Smad4 and p53 gene alterations in colorectal metastases and their role in the metastatic process.
Neoplasm Metastasis
Association of K-ras mutations with liver metastases from colorectal carcinoma.
Neoplasm Metastasis
Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
Neoplasm Metastasis
Bif-1 promotes tumor cell migration and metastasis via Cdc42 expression and activity.
Neoplasm Metastasis
Bioinformatic Prediction of Signaling Pathways for Apurinic/Apyrimidinic Endodeoxyribonuclease 1 (APEX1) and Its Role in Cholangiocarcinoma Cells.
Neoplasm Metastasis
Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis.
Neoplasm Metastasis
Bmi-1 promotes invasion and metastasis, and its elevated expression is correlated with an advanced stage of breast cancer.
Neoplasm Metastasis
BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.
Neoplasm Metastasis
BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells.
Neoplasm Metastasis
BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer. An immunohistochemical study.
Neoplasm Metastasis
Bronchioloalveolar adenocarcinoma of lung: monoclonal origin for multifocal disease.
Neoplasm Metastasis
Can K-ras codon 12 mutations be used to distinguish benign bile duct proliferations from metastases in the liver? A molecular analysis of 101 liver lesions from 93 patients.
Neoplasm Metastasis
CD47 Promotes Tumor Invasion and Metastasis in Non-small Cell Lung Cancer.
Neoplasm Metastasis
Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration.
Neoplasm Metastasis
Cdc42 promotes transendothelial migration of cancer cells through ?1 integrin.
Neoplasm Metastasis
Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.
Neoplasm Metastasis
Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases.
Neoplasm Metastasis
Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
Neoplasm Metastasis
Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
Neoplasm Metastasis
Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.
Neoplasm Metastasis
Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
Neoplasm Metastasis
Cetuximab for the first-line treatment of metastatic colorectal cancer.
Neoplasm Metastasis
Characterization and effects of miR-21 expression in esophageal cancer.
Neoplasm Metastasis
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
Neoplasm Metastasis
Characterization of EHop-016, a novel small molecule inhibitor of Rac GTPase.
Neoplasm Metastasis
CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
Neoplasm Metastasis
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Neoplasm Metastasis
Clinical significance of RacGAP1 expression at the invasive front of gastric cancer.
Neoplasm Metastasis
Clinical value of bile for the detection of mutant K-ras from colorectal liver metastases.
Neoplasm Metastasis
Clinicopathological pattern and Annexin A2 and Cdc42 status in patients presenting with differentiation and lymphnode metastasis of esophageal squamous cell carcinomas.
Neoplasm Metastasis
Clonal origin of multiple lung cancers: K-ras and p53 mutations determined by nonradioisotopic single-strand conformation polymorphism analysis.
Neoplasm Metastasis
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Neoplasm Metastasis
Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1? pathway to predict survival in resectable pancreatic cancer.
Neoplasm Metastasis
Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
Neoplasm Metastasis
Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
Neoplasm Metastasis
Comparison of oncogene mutation detection and telomerase activity for the molecular staging of non-small cell lung cancer.
Neoplasm Metastasis
Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
Neoplasm Metastasis
Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-ras status for unresectable colorectal liver metastasis (BECK study).
Neoplasm Metastasis
Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-RAS status for unresectable colorectal liver metastasis (BECK study): Long-term results of survival.
Neoplasm Metastasis
Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a.
Neoplasm Metastasis
Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Neoplasm Metastasis
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
Neoplasm Metastasis
Cost-effectiveness of targeted therapy with cetuximab in patients with K-ras wild-type colorectal cancer presenting with initially unresectable metastases limited to the liver in a German setting.
Neoplasm Metastasis
Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2.
Neoplasm Metastasis
CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
Neoplasm Metastasis
CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1.
Neoplasm Metastasis
Cucurbitacin I Inhibits Rac1 Activation in Breast Cancer Cells by a Ros-Mediated Mechanism and Independently of Jak2 and P-Rex1.
Neoplasm Metastasis
Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
Neoplasm Metastasis
Cyclooxygenase-2 overexpression is a marker of poor prognosis in stage I non-small cell lung cancer.
Neoplasm Metastasis
DAB2IP Plays Important Clinical Significance and Correlates With Immune Infiltration in Renal Cell Carcinoma.
Neoplasm Metastasis
Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer.
Neoplasm Metastasis
Degradation of Tiam1 by casein kinase 1 and the SCF?TrCP ubiquitin ligase controls the duration of mTOR-S6K signaling.
Neoplasm Metastasis
Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
Neoplasm Metastasis
Deleted in Liver Cancer-1 (DLC1): An Emerging Metastasis Suppressor Gene.
Neoplasm Metastasis
Deregulation of SLIT2-Mediated Cdc42 Activity Is Associated with Esophageal Cancer Metastasis and Poor Prognosis.
Neoplasm Metastasis
Detection of activating mutations in the ras family genes in cytological specimens from lung-tumors.
Neoplasm Metastasis
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
Neoplasm Metastasis
Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.
Neoplasm Metastasis
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Neoplasm Metastasis
Detection of K-ras point mutations in mesenteric venous blood from colorectal cancer patients by enriched polymerase chain reaction and single-strand conformation polymorphism analysis.
Neoplasm Metastasis
Detection of multiple hepatic micrometastases in pancreatic adenocarcinoma with a solitary liver metastasis by direct sequencing of the K-ras gene: a case report.
Neoplasm Metastasis
Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer.
Neoplasm Metastasis
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer.
Neoplasm Metastasis
Detection of occult metastases in sentinel lymph nodes from colon cancer patients by K-ras mutation peptide nucleic acid clamp PCR.
Neoplasm Metastasis
Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival.
Neoplasm Metastasis
Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant.
Neoplasm Metastasis
Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
Neoplasm Metastasis
Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13.
Neoplasm Metastasis
Dissected peripancreatic tissue margin is a critical prognostic factor and is associated with a K-ras gene mutation in pancreatic ductal adenocarcinoma.
Neoplasm Metastasis
Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
Neoplasm Metastasis
Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations.
Neoplasm Metastasis
DNA alterations of microsatellite DNA, p53, APC and K-ras in Chinese colorectal cancer patients.
Neoplasm Metastasis
Donor polymorphisms of Rap1A rs494453 contribute to a higher risk of hepatocellular carcinoma recurrence following liver transplantation.
Neoplasm Metastasis
Down-regulation of miRNA-204 by LMP-1 enhances CDC42 activity and facilitates invasion of EBV-associated nasopharyngeal carcinoma cells.
Neoplasm Metastasis
Downregulation of Rab23 inhibits proliferation, invasion, and metastasis of human ovarian cancer.
Neoplasm Metastasis
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Neoplasm Metastasis
Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
Neoplasm Metastasis
Early detection of leptomeningeal metastasis by PCR examination of tumor-derived K-ras DNA in cerebrospinal fluid.
Neoplasm Metastasis
Effect of microRNA-206 on cytoskeleton remodelling by downregulating Cdc42 in MDA-MB-231 cells.
Neoplasm Metastasis
Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
Neoplasm Metastasis
Effects of CDC42 on the proliferation and invasion of gastric cancer cells.
Neoplasm Metastasis
Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential.
Neoplasm Metastasis
Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
Neoplasm Metastasis
Enhanced spontaneous metastasis of mouse carcinoma cells transfected with an activated c-Ha-ras-1 gene.
Neoplasm Metastasis
Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
Neoplasm Metastasis
Epidermal Growth Factor Receptor Mutation and Pathologic-Radiologic Correlation Between Multiple Lung Nodules with Ground-Glass Opacity Differentiates Multicentric Origin from Intrapulmonary Spread.
Neoplasm Metastasis
ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.
Neoplasm Metastasis
Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.
Neoplasm Metastasis
Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.
Neoplasm Metastasis
Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
Neoplasm Metastasis
Expression of chemokine receptor CCR5 correlates with the presence of hepatic molecular metastases in K-ras positive human colorectal cancer.
Neoplasm Metastasis
Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.
Neoplasm Metastasis
Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
Neoplasm Metastasis
Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.
Neoplasm Metastasis
Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.
Neoplasm Metastasis
Extended staging results from the detection of isolated tumor cells in the liver of colorectal cancer patients.
Neoplasm Metastasis
Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.
Neoplasm Metastasis
Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
Neoplasm Metastasis
Functionalized Graphene@Gold Nanostar/Lipid for Pancreatic Cancer Gene and Photothermal Synergistic Therapy under Photoacoustic/Photothermal Imaging Dual-Modal Guidance.
Neoplasm Metastasis
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.
Neoplasm Metastasis
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Neoplasm Metastasis
Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.
Neoplasm Metastasis
Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection.
Neoplasm Metastasis
Genetic detection of colorectal cancer cells in circulation and lymph nodes.
Neoplasm Metastasis
Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
Neoplasm Metastasis
Genetic markers of survival and liver recurrence after resection of liver metastases from colorectal cancer.
Neoplasm Metastasis
Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
Neoplasm Metastasis
Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation.
Neoplasm Metastasis
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Neoplasm Metastasis
Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.
Neoplasm Metastasis
Growth factor-mediated altered expression and regulation of S-adenosylmethionine decarboxylase in a H-ras transformed cell line capable of malignant progression.
Neoplasm Metastasis
H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises.
Neoplasm Metastasis
HCC-derived exosomes elicit HCC progression and recurrence by epithelial-mesenchymal transition through MAPK/ERK signalling pathway.
Neoplasm Metastasis
Hepatic disseminated tumor cells in colorectal cancer UICC stage 4 patients: prognostic implications.
Neoplasm Metastasis
Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
Neoplasm Metastasis
High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma.
Neoplasm Metastasis
High expression of small GTPase Rab3D promotes cancer progression and metastasis.
Neoplasm Metastasis
High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
Neoplasm Metastasis
Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
Neoplasm Metastasis
Homologous orthotopic implantation models of pancreatic ductal cancer in Syrian golden hamsters: which is better for metastasis research--cell implantation or tissue implantation?
Neoplasm Metastasis
Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
Neoplasm Metastasis
Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.
Neoplasm Metastasis
Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma Metastasis by Reducing SGSM1 Stability.
Neoplasm Metastasis
Identification of mRNA and non-coding RNA hubs using network analysis in organ tropism regulated triple negative breast cancer metastasis.
Neoplasm Metastasis
Identification of the potential biomarkers for the metastasis of rectal adenocarcinoma.
Neoplasm Metastasis
Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.
Neoplasm Metastasis
IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling.
Neoplasm Metastasis
Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
Neoplasm Metastasis
Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
Neoplasm Metastasis
In-depth NMR characterization of Rab4a structure, nucleotide exchange and hydrolysis kinetics reveals an atypical GTPase profile.
Neoplasm Metastasis
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
Neoplasm Metastasis
Inactivation of Rab27B-dependent signaling pathway by calycosin inhibits migration and invasion of ER-negative breast cancer cells.
Neoplasm Metastasis
Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
Neoplasm Metastasis
Increased expression of annexin A1 is correlated with K-ras mutation in colorectal cancer.
Neoplasm Metastasis
Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer.
Neoplasm Metastasis
Inhibiting the phosphatidylinositide 3-kinase pathway blocks radiation-induced metastasis associated with Rho-GTPase and Hypoxia-inducible factor-1 activity.
Neoplasm Metastasis
Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice.
Neoplasm Metastasis
Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations.
Neoplasm Metastasis
Inhibition of cancer cell invasion by new ((3,4-dihydroxy benzylidene)hydrazinyl)pyridine-3-sulfonamide analogs.
Neoplasm Metastasis
Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
Neoplasm Metastasis
Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42.
Neoplasm Metastasis
Inhibition of gastric cancer cell growth and invasion through siRNA-mediated knockdown of guanine nucleotide exchange factor Vav3.
Neoplasm Metastasis
Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer.
Neoplasm Metastasis
Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain.
Neoplasm Metastasis
Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells.
Neoplasm Metastasis
Integrin ?9 Suppresses Hepatocellular Carcinoma Metastasis by Rho GTPase Signaling.
Neoplasm Metastasis
Interaction between Peptidyl-prolyl Cis-trans Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance.
Neoplasm Metastasis
K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
Neoplasm Metastasis
K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
Neoplasm Metastasis
K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients.
Neoplasm Metastasis
K-ras mutation in Greek patients with poorly and moderately differenciated tumours of the lower intestinal tract.
Neoplasm Metastasis
K-ras mutation is an early event in pancreatic duct carcinogenesis in the Syrian golden hamster.
Neoplasm Metastasis
K-ras Mutation is Strongly Associated with Perineural Invasion and Represents an Independent Prognostic Factor of Intrahepatic Cholangiocarcinoma after Hepatectomy.
Neoplasm Metastasis
K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
Neoplasm Metastasis
K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
Neoplasm Metastasis
K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
Neoplasm Metastasis
K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
Neoplasm Metastasis
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
Neoplasm Metastasis
K-ras oncogene mutation in cancer and precancerous lesions of the gallbladder.
Neoplasm Metastasis
K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
Neoplasm Metastasis
K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis.
Neoplasm Metastasis
K-ras status does not predict successful hepatic resection of colorectal cancer metastasis.
Neoplasm Metastasis
Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
Neoplasm Metastasis
Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis.
Neoplasm Metastasis
Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC-7901 cells.
Neoplasm Metastasis
Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma.
Neoplasm Metastasis
KY1022, a small molecule destabilizing Ras via targeting the Wnt/?-catenin pathway, inhibits development of metastatic colorectal cancer.
Neoplasm Metastasis
Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice.
Neoplasm Metastasis
Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer.
Neoplasm Metastasis
Long non-coding RNA NEAT1 promotes tumor development and metastasis through targeting RAB9A in malignant melanoma.
Neoplasm Metastasis
Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer.
Neoplasm Metastasis
Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
Neoplasm Metastasis
Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-?/SMAD signaling.
Neoplasm Metastasis
Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer.
Neoplasm Metastasis
Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.
Neoplasm Metastasis
Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis.
Neoplasm Metastasis
Mechanism of WASP and WAVE family proteins in the progression of prostate cancer.
Neoplasm Metastasis
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
Neoplasm Metastasis
Metastasis is driven by sequential elevation of H-ras and Smad2 levels.
Neoplasm Metastasis
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
Neoplasm Metastasis
MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.
Neoplasm Metastasis
MicroRNA-105 is involved in TNF-?-related tumor microenvironment enhanced colorectal cancer progression.
Neoplasm Metastasis
MicroRNA-151 and its hosting gene FAK (focal adhesion kinase) regulate tumor cell migration and spreading of hepatocellular carcinoma.
Neoplasm Metastasis
MicroRNA-195 suppresses angiogenesis and metastasis of hepatocellular carcinoma by inhibiting the expression of VEGF, VAV2 and CDC42.
Neoplasm Metastasis
MicroRNA-30b-5p functions as a metastasis suppressor in colorectal cancer by targeting Rap1b.
Neoplasm Metastasis
MicroRNA-548j functions as a metastasis promoter in human breast cancer by targeting Tensin1.
Neoplasm Metastasis
MicroRNA-665 suppressed the invasion and metastasis of osteosarcoma by directly inhibiting RAB23.
Neoplasm Metastasis
MicroRNA?342?3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.
Neoplasm Metastasis
MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
Neoplasm Metastasis
Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
Neoplasm Metastasis
Minireview: Mouse Models of Rho GTPase Function in Mammary Gland Development, Tumorigenesis, and Metastasis.
Neoplasm Metastasis
miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.
Neoplasm Metastasis
miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.
Neoplasm Metastasis
MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively.
Neoplasm Metastasis
MiR-196a binding-site SNP regulates RAP1A expression contributing to esophageal squamous cell carcinoma risk and metastasis.
Neoplasm Metastasis
MiR-203 down-regulates Rap1A and suppresses cell proliferation, adhesion and invasion in prostate cancer.
Neoplasm Metastasis
miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation.
Neoplasm Metastasis
MiR-384 inhibits human colorectal cancer metastasis by targeting KRAS and CDC42.
Neoplasm Metastasis
MiR-429 regulates the metastasis and EMT of HCC cells through targeting RAB23.
Neoplasm Metastasis
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
Neoplasm Metastasis
MiR-622 inhibited colorectal cancer occurrence and metastasis by suppressing K-Ras.
Neoplasm Metastasis
Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression.
Neoplasm Metastasis
miR?367?3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.
Neoplasm Metastasis
miRNA-143 replacement therapy harnesses the proliferation and migration of colorectal cancer cells in vitro.
Neoplasm Metastasis
MKL1 Mediates TGF-? Induced RhoJ Transcription to Promote Breast Cancer Cell Migration and Invasion.
Neoplasm Metastasis
Modified mismatch polymerase chain reaction-restriction fragment length polymorphism detected mutations in codon 12 and 13 of exon 2 of K-
Neoplasm Metastasis
Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20.
Neoplasm Metastasis
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Neoplasm Metastasis
Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
Neoplasm Metastasis
Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
Neoplasm Metastasis
Molecular detection of clinical colorectal cancer metastasis: how should multiple markers be put to use?
Neoplasm Metastasis
Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.
Neoplasm Metastasis
Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients.
Neoplasm Metastasis
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Neoplasm Metastasis
Mutation status of genes encoding RhoA, Rac1, and Cdc42 GTPases in a panel of invasive human colorectal and breast tumors.
Neoplasm Metastasis
Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
Neoplasm Metastasis
Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
Neoplasm Metastasis
Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
Neoplasm Metastasis
Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice.
Neoplasm Metastasis
No back seat for a progression event-K-RAS as a therapeutic target in CRC.
Neoplasm Metastasis
Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.
Neoplasm Metastasis
Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells.
Neoplasm Metastasis
O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
Neoplasm Metastasis
Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-?B Axis that induces expression of MMP9 and uPA in human pancreas progenitor cells.
Neoplasm Metastasis
Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells.
Neoplasm Metastasis
Oncosuppressor methylation: A possible key role in colon metastatic progression.
Neoplasm Metastasis
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Neoplasm Metastasis
Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.
Neoplasm Metastasis
Overexpression and biological function of IQGAP3 in human pancreatic cancer.
Neoplasm Metastasis
Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer.
Neoplasm Metastasis
Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
Neoplasm Metastasis
Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma.
Neoplasm Metastasis
Overexpression of the secretory small GTPase Rab27B in human breast cancer correlates closely with lymph node metastasis and predicts poor prognosis.
Neoplasm Metastasis
p38{gamma} promotes breast cancer cell motility and metastasis through regulation of RhoC GTPase, cytoskeletal architecture, and a novel leading edge behavior.
Neoplasm Metastasis
p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
Neoplasm Metastasis
p8 expression controls pancreatic cancer cell migration, invasion, adhesion and tumorigenesis.
Neoplasm Metastasis
Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma.
Neoplasm Metastasis
Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis.
Neoplasm Metastasis
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Neoplasm Metastasis
Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
Neoplasm Metastasis
Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
Neoplasm Metastasis
Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
Neoplasm Metastasis
Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
Neoplasm Metastasis
Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?
Neoplasm Metastasis
Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks.
Neoplasm Metastasis
Presence of ras oncogene mutations and human papillomavirus DNA in human prostate carcinomas.
Neoplasm Metastasis
Pro-metastatic signaling by c-Met through RAC-1 and reactive oxygen species (ROS).
Neoplasm Metastasis
Progesterone and calcitriol reduce invasive potential of endometrial cancer cells by targeting ARF6, NEDD9 and MT1-MMP.
Neoplasm Metastasis
Prognostic factors of colorectal cancer: K-ras mutation, overexpression of the p53 protein, and cell proliferative activity.
Neoplasm Metastasis
Prognostic impact of K-RAS mutational status and primary tumor location in patients undergoing resection for colorectal cancer liver metastases: an update.
Neoplasm Metastasis
Prognostic impact of K-RAS mutational status and primary tumour location in patients undergoing resection for colorectal cancer liver metastases: A METHEPAR analysis (multicentre study in Argentina).
Neoplasm Metastasis
Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
Neoplasm Metastasis
Prognostic significance of Rab27 expression in solid cancer: a systematic review and meta-analysis.
Neoplasm Metastasis
Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinations.
Neoplasm Metastasis
Proteogenomic Analysis of Human Colon Carcinoma Cell Lines LIM1215, LIM1899, and LIM2405.
Neoplasm Metastasis
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
Neoplasm Metastasis
Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
Neoplasm Metastasis
RAB18 promotes proliferation and metastasis in hepatocellular carcinoma.
Neoplasm Metastasis
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Neoplasm Metastasis
RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
Neoplasm Metastasis
Rab27a plays a dual role in metastatic propensity of pancreatic cancer.
Neoplasm Metastasis
RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
Neoplasm Metastasis
RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
Neoplasm Metastasis
Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
Neoplasm Metastasis
Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
Neoplasm Metastasis
RAB37 Hypermethylation Regulates Metastasis and Resistance to Docetaxel-Based Induction Chemotherapy in Nasopharyngeal Carcinoma.
Neoplasm Metastasis
Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
Neoplasm Metastasis
RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
Neoplasm Metastasis
Rac inhibition as a novel therapeutic strategy for EGFR/HER2 targeted therapy resistant breast cancer.
Neoplasm Metastasis
Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer.
Neoplasm Metastasis
Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.
Neoplasm Metastasis
Rac1b negatively regulates TGF-?1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.
Neoplasm Metastasis
Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
Neoplasm Metastasis
Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
Neoplasm Metastasis
RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
Neoplasm Metastasis
Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
Neoplasm Metastasis
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Neoplasm Metastasis
ras gene mutations in ethmoid sinus adenocarcinoma: prognostic implications.
Neoplasm Metastasis
Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-?1/H-Ras signaling pathway.
Neoplasm Metastasis
Re. article entitled 'Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations'.
Neoplasm Metastasis
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Neoplasm Metastasis
Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates.
Neoplasm Metastasis
Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.
Neoplasm Metastasis
Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
Neoplasm Metastasis
Relevance of Ki-67 antigen expression and K-ras mutation in colorectal liver metastases.
Neoplasm Metastasis
Restoration of mutant K-Ras repressed miR-199b inhibits K-Ras mutant non-small cell lung cancer progression.
Neoplasm Metastasis
Rho family GTPases regulate mammary epithelium cell growth and metastasis through distinguishable pathways.
Neoplasm Metastasis
Rho GDP dissociation inhibitor 2 suppresses metastasis via unconventional regulation of RhoGTPases.
Neoplasm Metastasis
Rho GTPase RhoJ is Associated with Gastric Cancer Progression and Metastasis.
Neoplasm Metastasis
Rho GTPases link cytoskeletal rearrangements and activation processes induced via the tetraspanin CD82 in T lymphocytes.
Neoplasm Metastasis
Rho?associated kinase inhibitor, Y?27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
Neoplasm Metastasis
RHOB influences lung adenocarcinoma metastasis and resistance in a host-sensitive manner.
Neoplasm Metastasis
RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
Neoplasm Metastasis
RhoC Modulates Cell Junctions and Type I Interferon Response in Aggressive Breast Cancers.
Neoplasm Metastasis
RhoE is frequently downregulated in HCC and suppresses HCC invasion through antagonizing the Rho/ROCK/MYPT pathway.
Neoplasm Metastasis
RhoGTPases and Rho-effectors in hepatocellular carcinoma metastasis: ROCK N'Rho move it.
Neoplasm Metastasis
Rhoj Is a Novel Target for Progression and Invasion of Glioblastoma by Impairing Cytoskeleton Dynamics.
Neoplasm Metastasis
RNA Interference of IQ Motif Containing GTPase-Activating Protein 3 (IQGAP3) Inhibits Cell Proliferation and Invasion in Breast Carcinoma Cells.
Neoplasm Metastasis
RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells.
Neoplasm Metastasis
Rock2 stabilizes ?-catenin to promote tumor invasion and metastasis in colorectal cancer.
Neoplasm Metastasis
Role of ARHGAP24 in ADP Ribosylation Factor 6 (ARF6)-dependent Pseudopod Formation in Human Breast Carcinoma Cells.
Neoplasm Metastasis
Role of retinoids in the prevention and treatment of colorectal cancer.
Neoplasm Metastasis
Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer.
Neoplasm Metastasis
Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF-?B, c-Fos and NFATc1 transcription factors.
Neoplasm Metastasis
RPEL-family rhoGAPs link Rac/Cdc42 GTP loading to G-actin availability.
Neoplasm Metastasis
Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.
Neoplasm Metastasis
Selection for spontaneous metastasis after calcium phosphate-mediated transfer of DNA.
Neoplasm Metastasis
Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.
Neoplasm Metastasis
Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver.
Neoplasm Metastasis
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Neoplasm Metastasis
Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.
Neoplasm Metastasis
Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
Neoplasm Metastasis
SNX9 promotes metastasis by enhancing cancer cell invasion via differential regulation of RhoGTPases.
Neoplasm Metastasis
Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
Neoplasm Metastasis
Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.
Neoplasm Metastasis
Subgroup Analysis by Liver Metastasis in the FRESCO Trial Comparing Fruquintinib versus Placebo Plus Best Supportive Care in Chinese Patients with Metastatic Colorectal Cancer.
Neoplasm Metastasis
Successful Multidisciplinary Treatment with Secondary Metastatic Liver Resection after Downsizing by Palliative Second-Line Treatment of Colorectal Cancer: A Curative Option.
Neoplasm Metastasis
Suppression of A549 lung cancer cell migration by precursor let-7g microRNA.
Neoplasm Metastasis
Surgical treatment of hepatocellular carcinoma and related basic research with special reference to recurrence and metastasis.
Neoplasm Metastasis
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Neoplasm Metastasis
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
Neoplasm Metastasis
The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
Neoplasm Metastasis
The cancer-associated, gain-of-function TP53 variant P152Lp53 activates multiple signaling pathways implicated in tumorigenesis.
Neoplasm Metastasis
The E3-ligase E6AP Represses Breast Cancer Metastasis via Regulation of ECT2-Rho Signaling.
Neoplasm Metastasis
The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho.
Neoplasm Metastasis
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells.
Neoplasm Metastasis
The microRNA-367 Inhibits the Invasion and Metastasis of Gastric Cancer by Directly Repressing Rab23.
Neoplasm Metastasis
The MLK-related Kinase (MRK) Is a Novel RhoC Effector That Mediates Lysophosphatidic Acid (LPA)-stimulated Tumor Cell Invasion.
Neoplasm Metastasis
The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma.
Neoplasm Metastasis
The Presence of Mutations in the K-RAS Gene Does Not Affect Survival after Resection of Pulmonary Metastases from Colorectal Cancer.
Neoplasm Metastasis
The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area.
Neoplasm Metastasis
The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study.
Neoplasm Metastasis
The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.
Neoplasm Metastasis
The relationship between microvessel count and the expression of vascular endothelial growth factor, p53, and K-ras in non-small cell lung cancer.
Neoplasm Metastasis
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Neoplasm Metastasis
The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.
Neoplasm Metastasis
The secretory small GTPase Rab27B as a marker for breast cancer progression.
Neoplasm Metastasis
The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State.
Neoplasm Metastasis
The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease.
Neoplasm Metastasis
The Small GTPase ARF6 Stimulates ?-Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis.
Neoplasm Metastasis
The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.
Neoplasm Metastasis
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Neoplasm Metastasis
Timing of Novel Drug 1A-116 to Circadian Rhythms Improves Therapeutic Effects against Glioblastoma.
Neoplasm Metastasis
Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation.
Neoplasm Metastasis
TNF-? augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell.
Neoplasm Metastasis
Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Neoplasm Metastasis
Triptolide Inhibits Breast Cancer Cell Metastasis Through Inducing the Expression of miR-146a, a Negative Regulator of Rho GTPase.
Neoplasm Metastasis
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Neoplasm Metastasis
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.
Neoplasm Metastasis
Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases.
Neoplasm Metastasis
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
Neoplasm Metastasis
Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2.
Neoplasm Metastasis
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Neoplasm Metastasis
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Neoplasm Metastasis
Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.
Neoplasm Metastasis
Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial.
Neoplasm Metastasis
Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.
Neoplasm Metastasis
VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Neoplasm Metastasis
Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA.
Neoplasm Metastasis
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
Neoplasm Metastasis
[A Case of Rectal Cancer with Unresectable Liver Metastasis Responding to Rechallenge with FOLFIRI].
Neoplasm Metastasis
[A case of remnant liver metastases after resection of liver metastases from rectal cancer following treatment with 5-FU, L-OHP and CPT-11, with markedly effective treatment by cetuximab plus S-1].
Neoplasm Metastasis
[Ablation of p120-Catenin Altering the Activity of Small GTPase in Human Lung Cancer Cells.]
Neoplasm Metastasis
[Alterations in metastatic properties of hepatocellular carcinoma cell following H-ras oncogene transfection]
Neoplasm Metastasis
[Association of mutations of K-RAS oncogene and deletions of 18Q with lymph node metastasis of colorectal cancer]
Neoplasm Metastasis
[Cell kinetics of colorectal tumors with assessment by K-ras mutation and PCNA labeling index]
Neoplasm Metastasis
[Clinical significance of K-RAS and cytokeratine 20 markers in diagnosis of lymphogenic metastasis of pancreatic cancer]
Neoplasm Metastasis
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
Neoplasm Metastasis
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
Neoplasm Metastasis
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
Neoplasm Metastasis
[Effects of K-ras gene mutation on colon cancer cell line Caco-2 metastasis by regulating E-cadherin/beta-catenin/p120 protein complex formation and RhoA protein activity]
Neoplasm Metastasis
[Evaluation of prognostic factors in gynecological cancer examined by molecular biological study]
Neoplasm Metastasis
[Experiment study on the diagnostic value of bile K-ras gene mutation responsible to the hepatic metastasis of pancreatic cancer]
Neoplasm Metastasis
[HMGB1-a as potential target for therapy of hematological malignancies].
Neoplasm Metastasis
[Relationships between intrahepatic metastasis of hepatocellular carcinoma and in situ microenvironment, and the abundance of nm23-H1 H-ras mRNA]
Neoplasm Metastasis
[Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]
Neoplasm Metastasis
[Study of DNA microarray chip of associated genes of hydatidiform mole]
Neoplasm Metastasis
[Study on relationship of the K-ras mutation with the occurrence of colorectal liver metastasis and survival outcomes].
Neoplasm Metastasis
[The effect of antisense H-ras on growth and metastasis of a high metastatic tumor model of human hepatoma in nude mice LCI-D20]
Neoplasm Metastasis
[The relationship between lymphangiogenesis and lymphatic metastasis in murine hepatic carcinoma of high and low metastatic potentialities.]
Neoplasm Metastasis
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Neoplasm Micrometastasis
A Colorimetric Method for Detection of K-ras Codon 12 Point Mutations in DNA Extracted from Tissue and Peripheral Blood in Pancreatic Disorders.
Neoplasm Micrometastasis
Clinical application of K-ras oncogene mutations in pancreatic carcinoma: detection of micrometastases.
Neoplasm Micrometastasis
Detection of extrapancreatic nerve plexus invasion of pancreatic adenocarcinoma. Cytokeratin 19 staining and K-ras mutation.
Neoplasm Micrometastasis
Detection of multiple hepatic micrometastases in pancreatic adenocarcinoma with a solitary liver metastasis by direct sequencing of the K-ras gene: a case report.
Neoplasm Micrometastasis
Detection of mutant K-ras in dissected paraaortic lymph nodes of patients with pancreatic adenocarcinoma.
Neoplasm Micrometastasis
Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.
Neoplasm Micrometastasis
Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
Neoplasm Micrometastasis
Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
Neoplasm Micrometastasis
Quantitative detection of mutant alleles of the K-ras gene with minor groove binder-conjugated fluorogenic DNA probes.
Neoplasm Micrometastasis
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
Neoplasm Micrometastasis
Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death.
Neoplasm Micrometastasis
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
Neoplasm Micrometastasis
[K-ras mutations detection in paraaortic lymph nodes and its prognostic value after the surgical treatment of pancreas cancer]
Neoplasm, Residual
Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
Neoplasm, Residual
Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
Neoplasms
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Neoplasms
(1)H, (13)C and (15)N resonance assignment for the human K-Ras at physiological pH.
Neoplasms
12th codon mutation resulting in c-N-ras activation in acute myelogenous leukemia.
Neoplasms
14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling.
Neoplasms
2D-PAGE of ovarian cancer: analysis of soluble and insoluble fractions using medium-range immobilized pH gradients.
Neoplasms
4-nitrophenol exposure in T24 human bladder cancer cells promotes proliferation, motilities, and epithelial-to-mesenchymal transition.
Neoplasms
5' transcript replacement in vitro catalyzed by a group I intron-derived ribozyme.
Neoplasms
5'-AMP-activated protein kinase activity is elevated early during primary brain tumor development in the rat.
Neoplasms
5-Aza-2'-deoxycytidine is chemopreventive in a 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone-induced primary mouse lung tumor model.
Neoplasms
8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.
Neoplasms
?-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.
Neoplasms
?-Catenin activates Rho GTPase, promotes lymphangiogenesis and growth of tumor metastases.
Neoplasms
?-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.
Neoplasms
?Np63? suppresses cells invasion by downregulating PKC?/Rac1 signaling through miR-320a.
Neoplasms
A chemical biology screen reveals a role for Rab21-mediated control of actomyosin contractility in fibroblast-driven cancer invasion.
Neoplasms
A clinicopathologic and immunohistochemical study of 22 intraductal papillary mucinous neoplasms of the pancreas, with a review of the literature.
Neoplasms
A Colorimetric Method for Detection of K-ras Codon 12 Point Mutations in DNA Extracted from Tissue and Peripheral Blood in Pancreatic Disorders.
Neoplasms
A commercial real-time PCR kit provides greater sensitivity than direct sequencing to detect KRAS mutations: a morphology-based approach in colorectal carcinoma.
Neoplasms
A Covalent Calmodulin Inhibitor as a Tool to Study Cellular Mechanisms of K-Ras-Driven Stemness.
Neoplasms
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
Neoplasms
A detailed analysis of K-ras point mutations in relation to tumor progression and survival in colorectal cancer patients.
Neoplasms
A disconnect between antitumor and antiangiogenic effects of fluvastatin in vitro and in vivo.
Neoplasms
A dualistic model for endometrial carcinogenesis based on immunohistochemical and molecular genetic analyses.
Neoplasms
A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis.
Neoplasms
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
Neoplasms
A fast, sensitive and accurate high resolution melting (HRM) technology-based assay to screen for common K-ras mutations.
Neoplasms
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
Neoplasms
A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance.
Neoplasms
A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.
Neoplasms
A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.
Neoplasms
A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin.
Neoplasms
A Guanidyl-Based Bivalent Peptidomimetic Inhibits K-Ras Prenylation and Association with c-Raf.
Neoplasms
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
Neoplasms
A Historic Perspective and Overview of H-Ras Structure, Oncogenicity, and Targeting.
Neoplasms
A Jnk-Rho-Actin remodeling positive feedback network directs Src-driven invasion.
Neoplasms
A K-ras 13Gly-->Asp mutation is recognized by HLA-DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?
Neoplasms
A Light-Driven Therapy of Pancreatic Adenocarcinoma Using Gold Nanorods-Based Nanocarriers for Co-Delivery of Doxorubicin and siRNA.
Neoplasms
A Macropinocytosis-Intensifying Albumin Domain-Based scFv Antibody and Its Conjugate Directed against K-Ras Mutant Pancreatic Cancer.
Neoplasms
A member of the Ras oncogene family, RAP1A, mediates antileishmanial activity of monastrol.
Neoplasms
A method for the second-site screening of K-Ras in the presence of a covalently attached first-site ligand.
Neoplasms
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.
Neoplasms
A mouse strain defective in both T cells and NK cells has enhanced sensitivity to tumor induction by plasmid DNA expressing both activated H-Ras and c-Myc.
Neoplasms
A multi-functional imaging approach to high-content protein interaction screening.
Neoplasms
A murine model for the development of melanocytic nevi and their progression to melanoma.
Neoplasms
A Murine Model of K-RAS and ?-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.
Neoplasms
A New Class of Orthosteric uPARuPA Small-Molecule Antagonists Are Allosteric Inhibitors of the uPARVitronectin Interaction.
Neoplasms
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Neoplasms
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Neoplasms
A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.
Neoplasms
A novel caveolin-1/p85?/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion.
Neoplasms
A Novel CDC42 Mutation in an 11-Year Old Child Manifesting as Syndromic Immunodeficiency, Autoinflammation, Hemophagocytic Lymphohistiocytosis, and Malignancy: A Case Report.
Neoplasms
A novel high-specificity approach for colorectal neoplasia: Detection of K-ras2 oncogene mutation in normal mucosa.
Neoplasms
A novel K-ras mutation in colorectal cancer. A case report and literature review.
Neoplasms
A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.
Neoplasms
A novel point mutation at codon 146 of the K-ras gene in a human colorectal cancer identified by the polymerase chain reaction.
Neoplasms
A novel Ras antagonist regulates both oncogenic Ras and the tumor suppressor p53 in colon cancer cells.
Neoplasms
A novel role of Rho-kinase in the regulation of ligand-induced phosphorylated EGFR endocytosis via the early/late endocytic pathway in human fibrosarcoma cells.
Neoplasms
A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.
Neoplasms
A novel strategy for specifically down-regulating individual Rho GTPase activity in tumor cells.
Neoplasms
A one-step DGGE scanning method for detection of mutations in the K-, N-, and H-ras oncogenes: mutations at codons 12, 13 and 61 are rare in B-cell non-Hodgkin's lymphoma.
Neoplasms
A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes.
Neoplasms
A PCR-RFLP method for the detection of activated H-ras oncogene with a point mutation at codon 12 and 61.
Neoplasms
A personalized treatment for lung cancer: molecular pathways, targeted therapies, and genomic characterization.
Neoplasms
A phase I study of BMS-690514 in Japanese patients with advanced or metastatic solid tumors.
Neoplasms
A Phase I trial of H-ras antisense oligonucleotide ISIS 2503 administered as a continuous intravenous infusion in patients with advanced carcinoma.
Neoplasms
A phase I trial of ISIS 2503, an antisense inhibitor of H-ras, in combination with gemcitabine in patients with advanced cancer.
Neoplasms
A position 12-activated H-ras oncogene in all HS578T mammary carcinosarcoma cells but not normal mammary cells of the same patient.
Neoplasms
A preliminary result of three-dimensional microarray technology to gene analysis with endoscopic ultrasound-guided fine-needle aspiration specimens and pancreatic juices.
Neoplasms
A quantitative volumetric micro-computed tomography method to analyze lung tumors in genetically engineered mouse models.
Neoplasms
A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice.
Neoplasms
A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer.
Neoplasms
A relationship between K-ras gene mutations and some clinical and histologic variables in patients with primary colorectal carcinoma.
Neoplasms
A repeated pancreatectomy in the remnant pancreas 22 months after pylorus-preserving pancreatoduodenectomy for pancreatic adenocarcinoma.
Neoplasms
A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells.
Neoplasms
A role for small GTPase RhoA in regulating intracellular membrane traffic of lysosomes in invasive rat hepatoma cells.
Neoplasms
A Sensitized Screen for Genes Promoting Invadopodia Function In Vivo: CDC-42 and Rab GDI-1 Direct Distinct Aspects of Invadopodia Formation.
Neoplasms
A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.
Neoplasms
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
Neoplasms
A Targeted Quantitative Proteomic Approach Assesses the Reprogramming of Small GTPases during Melanoma Metastasis.
Neoplasms
A unifying mechanism in the initiation of cancer and other diseases by catechol quinones.
Neoplasms
A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.
Neoplasms
A vertically stacked, polymer, microfluidic point mutation analyzer: Rapid high accuracy detection of low-abundance K-ras mutations.
Neoplasms
A very large villous adenoma with an adjacent cancer of the rectum: an informative case for testing the proposed molecular basis of colorectal tumorigenesis.
Neoplasms
AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer.
Neoplasms
Abnormal expression of p120-catenin, E-cadherin, and small GTPases is significantly associated with malignant phenotype of human lung cancer.
Neoplasms
Absence of activating mutations in ras and gsp oncogenes in a cohort of nine patients with sporadic pediatric thyroid tumors.
Neoplasms
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma.
Neoplasms
Absence of H-ras point mutation at codon 12 in N-methyl-N-nitrosourea-induced hepatocellular neoplasms in the rat.
Neoplasms
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
Neoplasms
Absolute quantification of farnesylated Ras levels in complex samples using liquid chromatography fractionation combined with tryptic digestion and electrospray tandem mass spectrometry.
Neoplasms
ACB-PCR measurement of H-ras codon 61 CAA?CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues.
Neoplasms
ACB-PCR measurement of K-ras codon 12 mutant fractions in livers of Big Blue rats treated with N-hydroxy-2-acetylaminofluorene.
Neoplasms
ACB-PCR measurement of spontaneous and furan-induced H-ras Codon 61 CAA to CTA and CAA to AAA mutation in B6C3F1 mouse liver.
Neoplasms
ACB-PCR quantification of K-RAS codon 12 GAT and GTT mutant fraction in colon tumor and non-tumor tissue.
Neoplasms
Acinar-ductal-carcinoma sequence in transforming growth factor-alpha transgenic mice.
Neoplasms
Ack promotes tissue growth via phosphorylation and suppression of the Hippo pathway component Expanded.
Neoplasms
ACK1 is dispensable for development, skin tumor formation, and breast cancer cell proliferation.
Neoplasms
Acquired resistance to gefitinib: The contribution of mechanisms other than the T790M, MET, and HGF status.
Neoplasms
Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma.
Neoplasms
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-?B signaling pathways.
Neoplasms
Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype.
Neoplasms
Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.
Neoplasms
Activated K-ras is involved in regulation of integrin expression in human colon carcinoma cells.
Neoplasms
Activated Ras induces cytoplasmic vacuolation and non-apoptotic death in glioblastoma cells via novel effector pathways.
Neoplasms
Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis.
Neoplasms
Activated ras protein accelerates cell cycle progression to perturb madin-darby canine kidney cystogenesis.
Neoplasms
Activating K-Ras mutations outwith 'hotspot' codons in sporadic colorectal tumours - implications for personalised cancer medicine.
Neoplasms
Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial.
Neoplasms
Activating the Expression of Human K-rasG12D Stimulates Oncogenic Transformation in Transgenic Goat Fetal Fibroblast Cells.
Neoplasms
Activation of a c-K-ras oncogene by somatic mutation in mouse lymphomas induced by gamma radiation.
Neoplasms
Activation of c-myc and c-K-ras oncogenes in primary rat tumors induced by ionizing radiation.
Neoplasms
Activation of clg, a novel dbl family guanine nucleotide exchange factor gene, by proviral insertion at evi24, a common integration site in B cell and myeloid leukemias.
Neoplasms
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors.
Neoplasms
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Neoplasms
Activation of H-ras oncogenes in male B6C3F1 mouse liver tumors induced by vinthionine or 2-chloroethyl-methyl sulfide.
Neoplasms
Activation of Harvey ras oncogene by mutation at codon 12 is very rare in hemopoietic malignancies.
Neoplasms
Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.
Neoplasms
Activation of K-ras in aflatoxin B1-induced lung tumors from AC3F1 (A/J x C3H/HeJ) mice.
Neoplasms
Activation of K-ras in transplantable pancreatic ductal adenocarcinomas of Syrian golden hamsters.
Neoplasms
Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma.
Neoplasms
Activation of RhoB by hypoxia controls hypoxia-inducible factor-1alpha stabilization through glycogen synthase kinase-3 in U87 glioblastoma cells.
Neoplasms
Activation of the K-ras gene by insertion mutations in chemically induced rat renal mesenchymal tumors.
Neoplasms
Activation of the K-ras oncogene in colorectal neoplasms is associated with decreased apoptosis.
Neoplasms
Activation of the K-ras protooncogene in lung tumors from rats and mice chronically exposed to tetranitromethane.
Neoplasms
Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells.
Neoplasms
Activation of the Ran GTPase is subject to growth factor regulation and can give rise to cellular transformation.
Neoplasms
Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1.
Neoplasms
Active RAC1 Promotes Tumorigenic Phenotypes and Therapy Resistance in Solid Tumors.
Neoplasms
Additional evidence that the K-ras protooncogene is a candidate for the major mouse pulmonary adenoma susceptibility (Pas-1) gene.
Neoplasms
Additional value of K-ras point mutations in bronchial wash fluids for diagnosis of peripheral lung tumours.
Neoplasms
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
Neoplasms
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Neoplasms
Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma.
Neoplasms
ADP-ribosylation factor 6 regulates tumor cell invasion through the activation of the MEK/ERK signaling pathway.
Neoplasms
ADP-ribosylation of oncogenic Ras proteins by pseudomonas aeruginosa exoenzyme S in vivo.
Neoplasms
AFAP1-AS1, a long noncoding RNA upregulated in lung cancer and promotes invasion and metastasis.
Neoplasms
Ag3PO4 NP@MoS2 nanosheet enhanced F, S-doped BN quantum dot electrochemiluminescence biosensor for K-ras tumor gene detection.
Neoplasms
Akt pathway activation converts anaplastic astrocytoma to glioblastoma multiforme in a human astrocyte model of glioma.
Neoplasms
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
Neoplasms
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
Neoplasms
Allele-specific activation and expression of the K-ras gene in hybrid mouse lung tumors induced by chemical carcinogens.
Neoplasms
Allele-specific detection of K-ras oncogene expression in human non-small-cell lung carcinomas.
Neoplasms
Allele-specific, non-extendable primer blocker PCR (AS-NEPB-PCR) for DNA mutation detection in cancer.
Neoplasms
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.
Neoplasms
Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.
Neoplasms
Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers.
Neoplasms
Alpha-tubulin acetyltransferase/MEC-17 regulates cancer cell migration and invasion through epithelial-mesenchymal transition suppression and cell polarity disruption.
Neoplasms
ALS2, the small GTPase Rab17-interacting protein, regulates maturation and sorting of Rab17-associated endosomes.
Neoplasms
Alteration of the p53 tumor suppressor gene occurs independently of K-ras activation and more frequently in serous adenocarcinomas than in other common epithelial tumors of the human ovary.
Neoplasms
Alterations in K-ras, APC and p53-multiple genetic pathway in colorectal cancer among Indians.
Neoplasms
Alterations in membrane-bound and cytoplasmic K-ras protein levels in mouse lung induced by treatment with lovastatin, cholestyramine, or niacin: effects are highly mouse strain dependent.
Neoplasms
Alterations of K-ras and p53 mutations in colorectal cancer patients in Central Europe.
Neoplasms
Alterations of oncogenes, tumor suppressor genes and growth factors in hepatocellular carcinoma: with relation to tumor size and invasiveness.
Neoplasms
Alterations of p53, cyclin D1, Rb, and H-ras in human oral carcinomas related to tobacco use.
Neoplasms
Alterations of protein kinase C, 8-hydroxydeoxyguanosine, and K-ras oncogene in rat lungs exposed to passive smoking.
Neoplasms
Alterations of the K-ras and p53 genes and microsatellite instability in sporadic colorectal carcinomas.
Neoplasms
Alterations of the K-ras and p53 genes in Tamoxifen-associated endometrial carcinoma.
Neoplasms
Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium.
Neoplasms
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Neoplasms
Altered adhesive structures and their relation to RhoGTPase activation in merlin-deficient Schwannoma.
Neoplasms
Altered detoxification status and increased resistance to oxidative stress by K-ras transformation.
Neoplasms
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Neoplasms
Altered intracellular region of MUC1 and disrupted correlation of polarity-related molecules in breast cancer subtypes.
Neoplasms
Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
Neoplasms
American College of Radiology thyroid imaging report and data system combined with K-RAS mutation improves the management of cytologically indeterminate thyroid nodules.
Neoplasms
Amplification of epidermal growth factor receptor gene but no evidence of ras mutations in primary human esophageal cancers.
Neoplasms
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
Neoplasms
An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.
Neoplasms
An adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis complexes with dynein and a small GTPase.
Neoplasms
An attempt to isolate genes responsible for spontaneous and experimental metastasis in the mouse model.
Neoplasms
An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression.
Neoplasms
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.
Neoplasms
An overview of genetic mutations and epigenetic signatures in the course of pancreatic cancer progression.
Neoplasms
An unexpected new role of mutant Ras: perturbation of human embryonic development.
Neoplasms
Analogues and Derivatives of Oncrasin-1, a Novel Inhibitor of the C-Terminal Domain of RNA Polymerase II and Their Antitumor Activities.
Neoplasms
Analyses on K-ras mutations and fascin expression in patients with cardia cancer.
Neoplasms
Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator.
Neoplasms
Analysis of h-ras, k-ras and N-ras genes for expression, mutation and amplification in laryngeal tumors.
Neoplasms
Analysis of HER-3, insulin growth factor-1, nuclear factor-kB and epidermal growth factor receptor gene copy number in the prediction of clinical outcome for K-RAS wild-type colorectal cancer patients receiving irinotecan-cetuximab.
Neoplasms
Analysis of K-ras and p53 mutations in mesotheliomas from humans and rats exposed to asbestos.
Neoplasms
Analysis of K-ras codon 12 and TP53 mutations in patients with advanced colorectal carcinoma.
Neoplasms
Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule-aggregating tumors.
Neoplasms
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Neoplasms
Analysis of K-ras gene mutations in malignant and nonmalignant endobronchial tissue obtained by fiberoptic bronchoscopy.
Neoplasms
Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.
Neoplasms
Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors.
Neoplasms
Analysis of K-ras oncogene mutation directly applied to atypical cell clusters on cytologic smear slides of bile and pancreatic juice.
Neoplasms
Analysis of K-ras, APC, and beta-catenin in aberrant crypt foci in sporadic adenoma, cancer, and familial adenomatous polyposis.
Neoplasms
Analysis of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the colorectum.
Neoplasms
Analysis of K-ras, p53 and c-raf-1 mutations in beryllium-induced rat lung tumors.
Neoplasms
Analysis of loss of heterozygosity in atypical and negative bile duct brushing cytology specimens with malignant outcome: are "false-negative" cytologic findings a representation of morphologically subtle molecular alterations?
Neoplasms
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.
Neoplasms
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Neoplasms
Analysis of mutations in the K-ras and p53 genes of lung tumors and in the hprt gene of 6-thioguanine-resistant T-lymphocytes from rats treated with 1,6-dinitropyrene.
Neoplasms
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
Neoplasms
Analysis of p53 and K-ras genes and their proteins in a sarcoma botryoides of the uterine cervix.
Neoplasms
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
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Analysis of ras gene mutations in biliary and pancreatic tumors by polymerase chain reaction and direct sequencing.
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Analysis of ras gene mutations in hepatocellular carcinoma in southern African blacks.
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Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing.
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Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
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Analysis of the allele-specific PCR method for the detection of neoplastic disease.
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Analysis of the c-myc, K-ras and p53 genes in methylcholanthrene-induced mouse sarcomas.
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Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods.
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Analysis of the Harvey ras gene in cisplatin-initiated mouse skin tumors by polymerase chain reaction and direct DNA sequencing.
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Analysis of the K-ras/B-raf/Erk signal cascade, p53 and CMAP as markers for tumor progression in colorectal cancer patients.
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Analysis of tumor progression by transcriptional profiling of mouse MK16 cell lines transformed with human papillomavirus type 16 E6 and E7 oncogenes and activated H-ras.
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Analysis of tumor-host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation.
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Anaplastic Lymphoma Kinase (ALK) Kinase Domain Mutation Following ALK Inhibitor(s) Failure in Advanced ALK Positive Non-Small-Cell Lung Cancer: Analysis and Literature Review.
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Anchorage-independent growth and the expression of cellular proto-oncogenes in normal human epidermal keratinocytes and in human squamous cell carcinoma cell lines.
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Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer.
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Aneuploidy mechanisms in human colorectal preneoplastic lesions and Barrett's esophagus. Is there a role for K-ras and p53 mutations?
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Another Surprise from Metformin: Novel Mechanism of Action via K-Ras Influences Endometrial Cancer Response to Therapy.
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Anti-apoptotic and oncogenic properties of the dsRNA-binding protein of vaccinia virus, E3L.
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Anti-K-ras ribozyme induces growth inhibition and increased chemosensitivity in human colon cancer cells.
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Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation.
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Anti-tumor effects of phenolic alkaloids of menispermum dauricum on gastric cancer in vivo and in vitro.
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Anti-tumorigenic effect of a K-ras ribozyme against human lung cancer cell line heterotransplants in nude mice.
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Anticancer mechanisms of doxorubicin and zoledronic acid in breast cancer tumor growth in bone.
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Anticoagulation therapy promotes the tumor immune-microenvironment and potentiates the efficacy of immunotherapy by alleviating hypoxia.
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Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines.
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Antisense therapy specific to mutated K-ras gene in hamster pancreatic cancer model. Can it inhibit the growth of 5-FU and MMC-resistant metastatic and remetastatic cell lines?
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Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition.
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Antitumor activity of an oncolytic adenovirus-delivered oncogene small interfering RNA.
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Antitumor activity of ER-51785, a new peptidomimetic inhibitor of farnesyl transferase: synergistic effect in combination with paclitaxel.
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Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice.
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Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
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Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
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Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
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APC, K-ras codon 12 mutations and p53 gene expression in carcinoma and adenoma of the gall-bladder suggest two genetic pathways in gall-bladder carcinogenesis.
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APC, K-ras, and p53 gene mutations in colorectal cancer patients: correlation to clinicopathologic features and postoperative surveillance.
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Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
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Apoptosis in relation to proliferating cell nuclear antigen and Dukes' stage in colorectal adenocarcinoma.
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Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA--in vitro and in vivo studies.
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Application of clonal analysis. Differential diagnosis for synchronous primary ovarian and endometrial cancers and metastatic cancer.
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Application of FTIR microscopy for the characterization of malignancy: H-ras transfected murine fibroblasts as an example.
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Application of gene expression profiling to colon cell maturation, transformation and chemoprevention.
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Application of the p53 and K-ras gene mutation patterns for cytologic diagnosis of recurrent lung carcinomas.
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Application of the restriction site mutation technique to N-methyl-N-nitrosourea-induced mutations in the rat.
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Applying Antibodies Inside Cells: Principles and Recent Advances in Neurobiology, Virology and Oncology.
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Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange.
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Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer?
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Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial ?1 integrin recycling.
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ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
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ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.
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ARHGAP17 suppresses tumor progression and up-regulates P21 and P27 expression via inhibiting PI3K/AKT signaling pathway in cervical cancer.
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ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells.
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Aristolochic acid as a probable human cancer hazard in herbal remedies: a review.
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Aristolochic acid-induced carcinogenesis examined by ACB-PCR quantification of H-Ras and K-Ras mutant fraction.
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Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates.
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Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer.
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Assessment of the mutagenicity of dichloroacetic acid in lacI transgenic B6C3F1 mouse liver.
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Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
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Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
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Association of deficient DNA repair during G2 phase with progression from benign to malignant state in a line of human skin keratinocytes transfected with ras oncogene.
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Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients.
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Association of genetic variants of O6-methylguanine-DNA methyltransferase with risk of lung cancer in non-Hispanic Whites.
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Association of K-ras codon 12 transversions with short survival in non-small cell lung cancer.
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Association of K-ras mutational status and clinical outcomes in patients with metastatic colorectal cancer receiving panitumumab alone.
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Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab.
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Association of matrilysin mRNA expression with K-ras mutations and progression in pancreatic ductal adenocarcinomas.
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Association of p53, K-ras and proliferating cell nuclear antigen with rat lung lesions following exposure to simulated nuclear fuel particles.
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Association of polymorphisms in AKT1 and EGFR with clinical outcome and toxicity in non-small cell lung cancer patients treated with gefitinib.
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Association of sonic hedgehog signaling pathway genes IHH, BOC, RAB23a and MIR195-5p, MIR509-3-5p, MIR6738-3p with gastric cancer stage.
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Association of the SS genotype of the L-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers.
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Associations between markers of colorectal cancer stem cells, mutation, microRNA and the clinical features of ulcerative colitis.
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ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance.
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Attenuated expression and function of the RECK tumor suppressor under hypoxic conditions is mediated by the MAPK signaling pathways.
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Augmentation of immune response by an analog of the antigenic peptide in a human T-cell clone recognizing mutated Ras-derived peptides.
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Automated real-time PCR to determine K-ras codon 12 mutations in non-small cell lung cancer: comparison with immunohistochemistry and clinico-pathological features.
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Bacterial Biotransformation and Anticancer Activities of Betulin against A549, HepG2 and 5RP7 Cancer Cell Lines.
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Basic fibroblast growth factor selectively regulates ornithine decarboxylase gene expression in malignant H-ras transformed cells.
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BAY61-3606 Affects the Viability of Colon Cancer Cells in a Genotype-Directed Manner.
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Bcl-3 promotes multi-modal tumour cell migration via NF-?B1 mediated regulation of Cdc42.
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BCR expression is decreased in meningiomas showing loss of heterozygosity of 22q within a new minimal deletion region.
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beta-Catenin mutation is selected during malignant transformation in colon carcinogenesis.
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Beta-catenin mutations in liver tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in CDF1 mice.
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Bevacizumab in combination with chemotherapy: first-line treatment of patients with metastatic colorectal cancer.
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Beyond the Genomic Mutation: Rethinking the Molecular Biomarkers of K-RAS Dependency in Pancreatic Cancers.
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Bif-1 promotes tumor cell migration and metastasis via Cdc42 expression and activity.
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Biliopancreatic malignancy: screening the at risk patient with molecular markers.
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Binding of wild-type and mutant forms of p53 protein from human tumors to a specific DNA-sequence of the first intron of the h-ras oncogene.
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Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.
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Biological significance of aminophenyl-?-carboline derivatives formed from co-mutagenic action of ?-carbolines and aniline and o-toluidine and its effect on tumorigenesis in humans: A review.
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Biomarker discovery, development, and implementation in france: a report from the French national cancer institute and cooperative groups.
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Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists.
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Black tea extract can modulate protein expression of H-ras, c-Myc, p53, and Bcl-2 genes during pulmonary hyperplasia, dysplasia, and carcinoma in situ.
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Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair.
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Blockage of transferred exosome-shuttled miR-494 inhibits melanoma growth and metastasis.
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Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs.
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Blocking K-Ras Interaction With the Plasma Membrane Is a Tractable Therapeutic Approach to Inhibit Oncogenic K-Ras Activity.
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Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function.
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Bmi-1 Cooperates with H-Ras to Transform Human Mammary Epithelial Cells via Dysregulation of Multiple Growth-Regulatory Pathways.
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BNIPL-2 promotes the invasion and metastasis of human hepatocellular carcinoma cells.
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Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region.
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Bone Marrow-Derived Mesenchymal Stem Cells Differentially Affect Glioblastoma Cell Proliferation, Migration, and Invasion: A 2D-DIGE Proteomic Analysis.
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Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
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Both K-ras and H-ras protooncogene mutations are associated with Harderian gland tumorigenesis in B6C3F1 mice exposed to isoprene for 26 weeks.
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Bracken fern-induced malignant tumors in rats: absence of mutations in p53, H-ras and K-ras and no microsatellite instability.
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BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study.
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BRAF mutation associated with dysregulation of apoptosis in human colorectal neoplasms.
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BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer.
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BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
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BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.
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BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas.
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BRCA1, C-erbB-2, and H-ras gene expressions in young women with breast cancer. An immunohistochemical study.
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Breaking bad family ties: Pan-ERBB blockers inhibit KRAS driven lung tumorigenesis.
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Bronchioloalveolar lung carcinomas: K-ras mutations are constant events in the mucinous subtype.
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c-K-ras overexpression is characteristic for metastases derived from a methylcholanthrene-induced fibrosarcoma.
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c-Ki-ras point mutations in ductectatic-type mucinous cystic neoplasms of the pancreas.
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Cadmium malignantly transforms normal human breast epithelial cells into a basal-like phenotype.
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Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells.
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Can Different Thyroid Tumor Types Be Distinguished by Polymerase Chain Reaction-Based K-ras Mutation Detection?
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Carcinogen and dietary lipid regulate ras expression and localization in rat colon without affecting farnesylation kinetics.
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Carcinogen exposure, p53 alteration, and K-ras mutation in synchronous multiple primary lung carcinoma.
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Carcinogen specificity in the activation of transforming genes by direct-acting alkylating agents.
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Carcinogen-induced colon tumors in mice are chromosomally stable and are characterized by low-level microsatellite instability.
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Carcinogen-induced liver tumours of Wistar rats: absence of activated ras genes and of N-rasC.
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Carcinogenesis of cancer of the papilla and ampulla: pathophysiological facts and molecular biological mechanisms.
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Carcinogenic mechanisms of endometrial cancer: involvement of genetics and epigenetics.
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Carcinogenicity, DNA adduct formation and K-ras activation by 7H-dibenzo[c,g]carbazole in strain A/J mouse lung.
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Carcinoma of the colon in childhood; report of 2 cases expressing p53 without K-ras mutation.
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Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
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Case of Invasive Carcinoma Derived from Intraductal Papillary Mucinous Neoplasm Negative for GNAS Mutation.
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Caveolin-1 is a novel regulator of K-RAS-dependent migration in colon carcinogenesis.
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CD44 expression in colorectal adenomas is an early event occurring prior to K-ras and p53 gene mutation.
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CD8+ T cells from a patient with colon carcinoma, specific for a mutant p21-Ras-derived peptide (Gly13-->Asp), are cytotoxic towards a carcinoma cell line harbouring the same mutation.
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CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability.
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Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.
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Cdc42 and Rac1 are necessary for autotaxin-induced tumor cell motility in A2058 melanoma cells.
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Cdc42 and Rac1 regulate late events in Salmonella typhimurium-induced interleukin-8 secretion from polarized epithelial cells.
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Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration.
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CDC42 Gtpase Activation Affects Hela Cell DNA Repair and Proliferation Following UV Radiation-Induced Genotoxic Stress.
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Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism.
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Cdc42 negatively regulates intrinsic migration of highly aggressive breast cancer cells.
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Cdc42 regulates schwann cell radial sorting and myelin sheath folding through NF2/merlin-dependent and independent signaling.
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Cdc42 Signaling Pathway Inhibition as a Therapeutic Target in Ras-Related Cancers.
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Cdc42 subcellular relocation in response to VEGF/NRP1 engagement is associated with the poor prognosis of colorectal cancer.
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Cdc42-mediated supracellular cytoskeleton induced cancer cell migration under low shear stress.
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Cdc42: an effector and regulator of ErbB1 as a strategic target in breast cancer therapy.
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CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines.
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cDNA sequencing improves the detection of P53 missense mutations in colorectal cancer.
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CEA is the major PHA-L-reactive glycoprotein in colon carcinoma cell lines and tumors: relationship between K-ras activation and beta1-6 branching of N-linked carbohydrate on CEA.
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Cell autonomous angiotensin II signaling controls the pleiotropic functions of oncogenic K-Ras.
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Cell autonomous or systemic EGFR blockade alters the immune-environment in squamous cell carcinomas.
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Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo.
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Cell proliferation and drug resistance in hepatocellular carcinoma are modulated by Rho GTPase signals.
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Cell proliferation and prevalence of ras gene mutations in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors.
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Cell type-dependent HIF1 ?-mediated effects of hypoxia on proliferation, migration and metastatic potential of human tumor cells.
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Cell-permeable CaaX-peptides affect K-Ras downstream signaling and promote cell death in cancer cells.
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Cell-to-cell contact-mediated regulation of tumor behavior in the tumor microenvironment.
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Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.
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Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways.
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Cellular protoonocogenes are infrequently amplified in untreated non-small cell lung cancer.
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Cellular redox imbalance and changes of protein S-glutathionylation patterns are associated with senescence induced by oncogenic H-ras.
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Ceramide 1-phosphate regulates cell migration and invasion of human pancreatic cancer cells.
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Cetuximab and circadian chronomodulated chemotherapy as salvage treatment for metastatic colorectal cancer (mCRC): safety, efficacy and improved secondary surgical resectability.
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Cetuximab in the first-line treatment of K-ras wild-type metastatic colorectal cancer: the choice and schedule of fluoropyrimidine matters.
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Cetuximab-based therapy for metastatic colorectal cancer: a meta-analysis of the effect of K-ras mutations.
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cGMP-dependent protein kinase phosphorylates p21-activated kinase (Pak) 1, inhibiting Pak/Nck binding and stimulating Pak/vasodilator-stimulated phosphoprotein association.
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Chalcones bearing a 3,4,5-trimethoxyphenyl motif are capable of selectively inhibiting oncogenic K-Ras signaling.
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Changes in actin and E-cadherin expression induced by 5-aminolevulinic acid photodynamic therapy in normal and Ras-transfected human mammary cell lines.
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Changes in cancer cell metabolism revealed by direct sample analysis with MALDI mass spectrometry.
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Changes in protein expression after neoadjuvant use of aromatase inhibitors in primary breast cancer: a proteomic approach to search for potential biomarkers to predict response or resistance.
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Characterisation of a subtype of colorectal cancer combining features of the suppressor and mild mutator pathways.
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Characterisation of colorectal cancers showing hypermethylation at multiple CpG islands.
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Characterization of K-ras gene mutations in association with mucinous hypersecretion in intraductal papillary-mucinous neoplasms.
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Characterization of pancreatic lesions from MT-tgfalpha, Ela-myc and MT-tgfalpha/Ela-myc single and double transgenic mice.
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Characterization of primary breast carcinomas grown in three-dimensional cultures.
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Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro.
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Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
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CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients.
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Chemical reverse transformation of CHO-K1 cells induces changes in expression of a candidate tumour suppressor and of a gene not previously characterised as transformation related.
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Chemistry and biology of moverastins, inhibitors of cancer cell migration, produced by Aspergillus.
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Chemopreventive effect of perillyl alcohol on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced tumorigenesis in (C3H/HeJ X A/J)F1 mouse lung.
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Chemopreventive properties of trans-resveratrol are associated with inhibition of activation of the IkappaB kinase.
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Chimaerins: GAPs that bridge diacylglycerol signalling and the small G-protein Rac.
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Cholangiocarcinoma in primary sclerosing cholangitis: K-ras mutations and Tp53 dysfunction are implicated in the neoplastic development.
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Chromosomal changes and correspondingly altered proto-oncogene expression in human gliomas. Value of combined cytogenetic and molecular genetic analysis.
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Chromosome aberrations and expression of ras and myc oncogenes in leiomyomas and a leiomyosarcoma of the uterus.
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Chromosome aberrations [dup(1q)] in endometrial cancer: Gene analysis of 54 surgical specimens in Turkey.
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Chromosome losses in tumorigenic revertants of EJ/ras-expressing somatic cell hybrids.
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Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells.
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Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats.
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Chronic lymphocytic leukemia cells induce defective LFA-1-directed T cell motility by altering Rho GTPase signaling that is reversible with lenalidomide.
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Chronic p27Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid Receptor.
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Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
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CHUK/IKK-? loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation.
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Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
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Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung.
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CircRNA hsa_circ_0030018 regulates the development of glioma via regulating the miR-1297/RAB21 axis.
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Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway.
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Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
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Classification of advanced colorectal carcinomas by tumor edge morphology: evidence for different pathogenesis and significance of polypoid and nonpolypoid tumors.
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Clinical and genetic analysis of noncancerous and cancerous biliary epithelium in patients with pancreaticobiliary maljunction.
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Clinical impact of K-ras mutation analysis in EUS-guided FNA specimens from pancreatic masses.
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Clinical implications of K-ras mutations in malignant epithelial tumors of the endometrium.
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Clinical outcome of patients with non-small cell lung cancer receiving front-line chemotherapy according to EGFR and K-RAS mutation status.
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Clinical relevance of H-RAS, K-RAS, and N-RAS mRNA expression in primary breast cancer patients.
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Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer.
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Clinical significance and the correlation of expression between Let-7 and K-ras in non-small cell lung cancer.
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Clinical significance of cathepsin E in pancreatic juice in the diagnosis of pancreatic ductal adenocarcinoma.
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Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
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Clinical significance of K-Ras mutations in intraoperative tumor drainage blood from patients with colorectal carcinoma.
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Clinical significance of p53, K-ras and DCC gene alterations in the stage I-II colorectal cancers.
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Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.
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Clinical usefulness of K-RAS mutation detection in colorectal cancer and in surgical margins of the colon.
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Clinical value of bile for the detection of mutant K-ras from colorectal liver metastases.
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Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis.
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Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer.
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Clinico-pathological study of K-ras mutations in colorectal tumors in Saudi Arabia.
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Clinico-Pathological Study of K-ras Mutations in Colorectal Tumors: A Single-Center Retrospective Study of 51 Patients in Madinah, Saudi Arabia.
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Clinicopathologic analysis of k-ras, p53, and ERBB-2 gene alterations in pulmonary adenocarcinoma.
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Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors.
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Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases.
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Clinicopathological and genetic characteristics of mucinous carcinomas in the colorectum.
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Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation.
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Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers.
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Clonal preservation of human pancreatic cell line derived from primary pancreatic adenocarcinoma.
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Clonality and K-ras mutation analyses of epithelia in intraductal papillary mucinous tumor and mucinous cystic tumor of the pancreas.
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Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia.
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Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
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Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential
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Cloning and characterization of a novel small monomeric GTPase, RasL10B, with tumor suppressor potential.
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Cloning and characterization of a novel splice variant of human Rab18 gene (RAB18)dagger.
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CNF1-induced ubiquitylation and proteasome destruction of activated RhoA is impaired in Smurf1-/- cells.
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CNF1-like deamidase domains: common Lego bricks among cancer-promoting immunomodulatory bacterial virulence factors.
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Co-dependency of PKC? and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer.
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Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
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Coamplification at lower denaturation temperature polymerase chain reaction enables selective identification of K-Ras mutations in formalin-fixed, paraffin-embedded tumor tissues without tumor-cell enrichment.
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Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice.
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Codon 64 of K-ras gene mutation pattern in hepatocellular carcinomas induced by bleomycin and 1-nitropyrene in A/J mice.
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Codon usage regulates human KRAS expression at both transcriptional and translational levels.
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Coexistence of somatic and germ-line mutations of APC gene in desmoid tumors from patients with familial adenomatous polyposis.
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Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel.
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Colorectal cancer: using blood samples and tumor tissue to detect K-ras mutations.
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Colorectal carcinogenesis based on molecular biology of early colorectal cancer, with special reference to nonpolypoid (superficial) lesions.
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Combination of dihydroartemisinin and resveratrol effectively inhibits cancer cell migration via regulation of the DLC1/TCTP/Cdc42 pathway.
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Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice.
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Combination of immunoprecipitation (IP)-ATP_Glo kinase assay and melanogenesis for the assessment of potent and safe PAK1-blockers in cell culture.
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Combination therapy with SCH58500 (p53 adenovirus) and cyclophosphamide in preclinical cancer models.
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Combination therapy with vidaza and entinostat suppresses tumor growth and reprograms the epigenome in an orthotopic lung cancer model.
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Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts.
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Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
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Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas.
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Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.
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Combined subcarcinogenic benzo[a]pyrene and UVA synergistically caused high tumor incidence and mutations in H-ras gene, but not p53, in SKH-1 hairless mouse skin.
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Comethylation of p16 and MGMT genes in colorectal carcinoma: correlation with clinicopathological features and prognostic value.
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Comment on "Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-call lung cancer patients" (Cancer Letters 2003;193:207-216).
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Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias.
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Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.
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Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers.
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Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.
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Comparative analysis of K-ras point mutation, telomerase activity, and p53 overexpression in pancreatic tumours.
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Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
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Comparative analysis of p16/CDKN2, p53 and ras gene alterations in human non-small cell lung cancers, with and without associated pulmonary asbestosis.
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Comparative analysis of p53 gene mutations and protein accumulation in human non-small-cell lung cancer.
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Comparative effects of oncogenic mutations G12C, G12V, G13D, and Q61H on local conformations and dynamics of K-Ras.
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Comparative immunohistochemical reactivity of monoclonal and polyclonal antibodies to H-ras p21 in normal and neoplastic tissues of rodents and humans.
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Comparative Screening of K-ras Mutations in Colorectal Cancer and Lung Cancer Patients Using a Novel Real-Time PCR with ADx-K-ras Kit and Sanger DNA Sequencing.
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Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.
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Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
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Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas.
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Comparison of features of human lung cancer cell lines and their corresponding tumors.
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Comparison of Ha-ras mutational spectra of N-methyldibenzo[c,g]carbazole and 7H-dibenzo[c,g]carbazole-induced mouse skin tumors.
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Comparison of K-ras gene mutations in tumour and sputum DNA of patients with lung cancer.
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Comparison of K-ras point mutation distributions in intraductal papillary-mucinous tumors and ductal adenocarcinoma of the pancreas.
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Comparison of Ki-67 antigen expression and K-ras mutation in lung tumours induced by urethane in mice.
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Comparison of mutations in the p53 and K-ras genes in lung carcinomas from smoking and nonsmoking women.
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Comparison of mutations of ras oncogene in human pancreatic exocrine and endocrine tumors.
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Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
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Comparison of ras-responsive gene enhancers in pancreatic tumor cells that express either wild-type or mutant K-ras.
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Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies.
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Complete Radiographic Response to Zoledronic Acid Therapy in a Patient With Bony Metastatic Urothelial Carcinoma: A Case Report.
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Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model.
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Comprehensive genomic analyses of a metastatic colon cancer to the lung by whole exome sequencing and gene expression analysis.
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Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status.
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Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth.
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Computational and in vitro Pharmacodynamics Characterization of 1A-116 Rac1 Inhibitor: Relevance of Trp56 in Its Biological Activity.
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Computational Modeling Reveals that Signaling Lipids Modulate the Orientation of K-Ras4A at the Membrane Reflecting Protein Topology.
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Concomitant activation of MEK-1 and Rac-1 increases the proliferative potential of thyroid epithelial cells, without affecting their differentiation.
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Conditional expression of mutated K-ras accelerates intestinal tumorigenesis in Msh2-deficient mice.
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Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase.
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Conformational SERS Classification of K-Ras Point Mutations for Cancer Diagnostics.
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Conformational transformation of switch domains in GDP/K-Ras induced by G13 mutants: An investigation through Gaussian accelerated molecular dynamics simulations and principal component analysis.
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Constitutively active Harvey Ras confers resistance to epidermal growth factor receptor-targeted therapy with cetuximab and gefitinib.
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Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression.
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Contextual inhibition of fatty acid synthesis by metformin involves glucose-derived acetyl-CoA and cholesterol in pancreatic tumor cells.
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Contribution of dichloroacetate and trichloroacetate to liver tumor induction in mice by trichloroethylene.
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Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression.
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Control by the endogenous cannabinoid system of ras oncogene-dependent tumor growth.
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Converged Rab37/IL-6 trafficking and STAT3/PD-1 transcription axes elicit an immunosuppressive lung tumor microenvironment.
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Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-ras status for unresectable colorectal liver metastasis (BECK study).
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Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K-RAS status for unresectable colorectal liver metastasis (BECK study): Long-term results of survival.
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Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation.
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Coordinated Regulation of Intracellular Fascin Distribution Governs Tumor Microvesicle Release and Invasive Cell Capacity.
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COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1? mediated tumor angiogenesis and proliferation.
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Coping with strong translational noncrystallographic symmetry and extreme anisotropy in molecular replacement with Phaser: human Rab27a.
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Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer.
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Copy number of cancer genes predict tumor grade and survival of pancreatic cancer patients.
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Correction: Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
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Correction: Targeting the ?4-?5 dimerization interface of K-RAS inhibits tumor formation in vivo.
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Correlated flow cytometric analysis of H-ras p21 and nuclear DNA in multiple myeloma.
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Correlation between Bcl-2 overexpression and H-ras mutation in naturally occurring hepatocellular proliferative lesions of the B6C3F1 mouse.
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Correlation between K-ras gene mutation and prognosis of patients with nonsmall cell lung carcinoma.
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Correlation between microsatellite instability and metachronous disease recurrence after endoscopic mucosal resection in patients with early stage gastric carcinoma.
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Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
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Correlation of cellular differentiation in human colorectal carcinoma and adenoma cell lines with metabolite profiles determined by 1H magnetic resonance spectroscopy.
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CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability.
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CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer.
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Critical role of PTEN for development and progression of nerve sheath tumors in neurofibromatosis type 1.
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Crystal Structure of a Human K-Ras G12D Mutant in Complex with GDP and the Cyclic Inhibitory Peptide KRpep-2d.
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CSE1L modulates Ras-induced cancer cell invasion: correlation of K-Ras mutation and CSE1L expression in colorectal cancer progression.
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CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma.
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CtBP2 Promotes Human Cancer Cell Migration by Transcriptional Activation of Tiam1.
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Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model.
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Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
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Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.
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CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression.
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Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
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Cyclin D1 harboring the T286I mutation promotes oncogenic activation in endometrial cancer.
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Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.
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Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation.
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Cyclooxygenase-2 overexpression is related to polypoid growth and K-ras gene mutation in T1 colorectal carcinomas.
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Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis.
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Cytogenetic alterations in eight mammary tumors and tumor-suppressor gene p53 mutation in one mammary tumor from dogs.
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Cytogenetic, ras, and p53: studies in cases of canine neoplasms (hemangiopericytoma, mastocytoma, histiocytoma, chloroma).
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Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.
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Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutation.
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Cytotoxicity induced by exposure to natural and synthetic tremolite asbestos: An in vitro pilot study.
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Dacarbazine-induced immunogenicity of a murine leukemia is attenuated in cells transfected with mutated K-ras gene.
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De novo CD5-positive and Richter's syndrome-associated diffuse large B cell lymphomas are genotypically distinct.
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Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism.
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Decrease in K-ras p21 and increase in Raf1 and activated Erk 1 and 2 in murine lung tumors initiated by N-nitrosodimethylamine and promoted by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
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Decreased c-kit function inhibits enhanced skin carcinogenesis in c-Ha-ras protooncogene transgenic mice.
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Decreased expression of miR-410-3p correlates with poor prognosis and tumorigenesis in human glioma.
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Decreased expression of Rab27A and Rab27B correlates with metastasis and poor prognosis in colorectal cancer.
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Decreased GTPase activity of K-ras mutants deriving from human functional adrenocortical tumours.
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Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors.
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Deficiency of a potential 3p21.3 tumor suppressor gene UBE1L (UBA7) does not accelerate lung cancer development in K-ras(LA2) mice.
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Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.
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Degradation of endothelial cell matrix collagen is correlated with induction of stromelysin by an activated ras oncogene.
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Dehydrotrametenolic acid selectively inhibits the growth of H-ras transformed rat2 cells and induces apoptosis through caspase-3 pathway.
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Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma.
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Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity.
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Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
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Denaturing gradient gel electrophoresis (DGGE) assay for K-ras and N-ras genes: detection of K-ras point mutations in human lung tumour DNA.
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DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior.
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DEP domain containing 1 predicts prognosis of hepatocellular carcinoma patients and regulates tumor proliferation and metastasis.
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Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.
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Deregulation of miR-146a expression in a mouse model of pancreatic cancer affecting EGFR signaling.
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Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.
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Designed diagnostic restriction fragment length polymorphisms for the detection of point mutations in ras oncogenes.
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Detecting K-ras mutations in stool from fecal occult blood test cards in multiphasic screening for colorectal cancer.
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Detection and characterization of oncogene mutations in preneoplastic and early neoplastic lesions.
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Detection and Characterization of Oncogene Mutations in Preneoplastic and Early Neoplastic Lesions.
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Detection and clinical correlations of ras gene mutations in human ovarian tumors.
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Detection and cloning of potent transforming gene(s) from chewing tobacco-related human oral carcinomas.
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Detection by denaturant gradient gel electrophoresis of tumor-specific mutations in biopsies and relative bronchoalveolar lavage fluid from resectable non-small cell lung cancer.
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Detection of a rare point mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer.
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Detection of activated K-ras in non-small cell lung cancer by membrane array: a comparison with direct sequencing.
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Detection of activated proto-oncogenes in N-nitrosodiethylamine-induced liver tumors: a comparison between B6C3F1 mice and Fischer 344 rats.
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Detection of APC and k-ras mutations in the serum of patients with colorectal cancer.
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Detection of circulating tumor cells in colorectal cancer by immunobead-PCR is a sensitive prognostic marker for relapse of disease.
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Detection of codon 12 K-ras mutations in non-neoplastic mucosa from bronchial carina in patients with lung adenocarcinomas.
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Detection of codon 12 point mutations of the K-ras gene from mouse lung adenocarcinoma by 'enriched' PCR.
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Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.
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Detection of dibenzo[a,l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method.
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Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
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Detection of human papillomavirus types 16 and 18 in human neoplastic endometrium: lack of correlation with established prognostic factors.
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Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues.
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Detection of isolated tumor cells by polymerase chain reaction-restriction fragment length polymorphism for K-ras mutations in tissue samples of 199 colorectal cancer patients.
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Detection of K-ras and p53 gene mutations in pancreatic juice for the diagnosis of intraductal papillary mucinous tumors.
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Detection of K-ras and p53 mutations in bronchoscopically obtained malignant and non-malignant tissue from patients with non-small cell lung cancer.
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Detection of K-ras and p53 mutations in sputum samples of lung cancer patients using laser capture microdissection microscope and mutation analysis.
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Detection of K-ras exon 1 mutations by constant denaturant capillary electrophoresis.
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Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
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Detection of K-ras gene mutations in feces by magnetic nanoprobe in patients with pancreatic cancer: A preliminary study.
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Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.
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Detection of K-ras mutation in colonic effluent samples from patients without evidence of colorectal carcinoma.
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Detection of k-ras mutation in normal and malignant colonic tissues by an enriched PCR method.
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Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer.
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Detection of K-ras mutations in azoxymethane-induced aberrant crypt foci in mice using LNA -mediated real-time PCR clamping and mutant-specific probes.
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Detection of K-ras mutations in DNAs isolated from feces of patients with colorectal tumors by mutant-allele-specific amplification (MASA).
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Detection of K-ras mutations in mucinous pancreatic duct hyperplasia from a patient with a family history of pancreatic carcinoma.
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Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
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Detection of K-ras mutations in stools of patients with colorectal cancer by mutant-enriched PCR.
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Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
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Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping.
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Detection of K-ras oncogene from the human genomic DNA using ultrasonication and a quantum dots-based microfluidic chip.
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Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
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Detection of K-ras point mutation at codon 12 in pure pancreatic juice collected 3 years and 6 months before the clinical diagnosis of pancreatic cancer.
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Detection of K-ras point mutations at codon 12 in pure pancreatic juice for the diagnosis of pancreatic cancer by PCR-RFLP analysis.
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Detection of k-ras point mutations in codons 12 and 13 in non-small cell lung cancers.
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Detection of K-ras point mutations in mesenteric venous blood from colorectal cancer patients by enriched polymerase chain reaction and single-strand conformation polymorphism analysis.
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Detection of K-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-EXACCT.
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Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
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Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer.
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Detection of mutant K-ras in dissected paraaortic lymph nodes of patients with pancreatic adenocarcinoma.
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Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: comparison with K-ras mutation.
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Detection of occult metastases in sentinel lymph nodes from colon cancer patients by K-ras mutation peptide nucleic acid clamp PCR.
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Detection of oncogenes in the diagnosis of cancers with active oncogenic signaling.
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Detection of p53 and K-ras mutations in sputum of individuals exposed to smoky coal emissions in Xuan Wei County, China.
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Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
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Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
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Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
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Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
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Detection of rare circulating human colon tumor cells in a nude mouse xenograft model.
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Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.
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Detection of ras oncogene point mutations and simultaneous proliferative fraction estimation in gallbladder cancer.
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Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumors by random amplified polymorphic DNA analysis.
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Detection of transforming oncogenes in rat colon tumors induced by direct perfusion with N-methyl-N-nitrosourea.
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Detection of tumor cells in blood using CD45 magnetic cell separation followed by nested mutant allele-specific amplification of p53 and K-ras genes in patients with colorectal cancer.
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Detection of two novel mutations and relatively high incidence of H-RAS mutations in Vietnamese oral cancer.
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Detection of UV-induced K-ras codon 12 mutation by PCR and differential dot-blot hybridization in cells from Down syndrome and Cockayne syndrome.
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Determinants of recurrence after intended curative resection for colorectal cancer.
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Determination of microsatellite instability, p53 and K-RAS mutations in hepatic metastases from patients with colorectal cancer: relationship with response to 5-fluorouracil and survival.
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Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials.
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Development of a rapid and practical mutation screening assay for human lung adenocarcinoma.
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Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium.
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Development of human cell models for assessing the carcinogenic potential of chemicals.
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Diacylglycerol kinase ? controls RCP-dependent integrin trafficking to promote invasive migration.
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Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
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Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
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Diagnosis of pancreatico-biliary malignancy: detection of gene mutations in plasma and stool.
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Diagnostic and prognostic value of incidence of K-ras codon 12 mutations in resected distal bile duct carcinoma.
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Diagnostic procedures for paraffin-embedded tissues analysis in pharmacogenomic studies.
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Diagnostic utility of K-ras mutational analysis on bile obtained by endoscopic retrograde cholangiopancreatography.
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Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
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Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis.
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Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
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Dietary phytate lowers K-ras mutational frequency, decreases DNA-adduct and hydroxyl radical formation in azoxymethane-induced colon cancer.
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Dietary supplementation of lutein reduces colon carcinogenesis in DMH-treated rats by modulating K-ras, PKB, and ?-catenin proteins.
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Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study.
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Differences between KC and KPC pancreatic ductal adenocarcinoma mice models, in terms of their modeling biology and their clinical relevance.
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Differences in carcinogenesis by the length of carcinogen exposure period in rat colon.
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Differences in K-ras and p53 gene mutations among pancreatic adenocarcinomas associated with regional environmental pollution.
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Differences in mucus and K-ras mutation in relation to phenotypes of tumors of the papilla of vater.
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Differences in the frequencies of K-ras c12-13 genotypes by gender and pathologic phenotypes in colorectal tumors measured using the allele discrimination method.
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Differences in the histological findings, phenotypic marker expressions and genetic alterations between adenocarcinoma of the gastric cardia and distal stomach.
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Different effects of point mutations within the B-Raf glycine-rich loop in colorectal tumors on mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase and nuclear factor kappaB pathway and cellular transformation.
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Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens.
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Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.
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Different pattern of metastasis in liver implanted pancreatic cancer between young and old Syrian golden hamsters.
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Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer.
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Differential (Ha-, K- and N-) ras p21 expression in benign and malignant human thyroid tumors: an immunohistochemical study.
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Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.
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Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon.
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Differential expression and activation of epidermal growth factor receptor 1 (EGFR1), ERK, AKT, STAT3, and TWIST1 in nonsmall cell lung cancer (NSCLC).
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Differential expression and mutation of the ras family genes in human breast cancer.
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Differential expression of cell cycle regulators in phenotypic variants of transgenically induced bladder tumors: implications for tumor behavior.
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Differential Expression of IL-17, 22 and 23 in the Progression of Colorectal Cancer in Patients with K-ras Mutation: Ras Signal Inhibition and Crosstalk with GM-CSF and IFN-?.
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Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42.
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Differential expression of the H-ras mutated and normal alleles in rabbit DMBA-induced keratoacanthomas.
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Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.
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Differential sensitivity of normal and H-ras oncogene-transformed rat kidney epithelial cells to okadaic acid-induced apoptosis.
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Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant.
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Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients.
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Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway.
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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.
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Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.
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Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.
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Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis.
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Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
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Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides.
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Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding.
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Discrepancies between the K-ras mutational status of primary colorectal cancers and corresponding liver metastases are found in codon 13.
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Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.
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Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling.
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Dissecting the different biological effects of oncogenic Ras isoforms in cancer cell lines: Could stimulation of oxidative stress be the one more weapon of H-Ras?: Regulation of oxidative stress and Ras biological effects.
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Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays.
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Dissociation mechanism of GDP from Cdc42 via DOCK9 revealed by molecular dynamics simulations.
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Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
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Distinct K-ras mutation pattern characterizes signet ring cell colorectal carcinoma.
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Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification.
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Distinctive molecular genetic alterations in sporadic and familial adenomatous polyposis-associated pancreatoblastomas : frequent alterations in the APC/beta-catenin pathway and chromosome 11p.
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Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: a PET imaging and metabolomics-mass-spectrometry study.
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Diverse subpopulations of vesicles secreted by different intracellular mechanisms are present in exosome preparations obtained by differential ultracentrifugation.
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DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.
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DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma.
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DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.
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DLC1 is unlikely to be a primary target for deletions on chromosome arm 8p22 in head and neck squamous cell carcinoma.
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DLC1 suppresses NF-?B activity in prostate cancer cells due to its stabilizing effect on adherens junctions.
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DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration.
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DLC2 operates as a tumor suppressor gene in breast cancer via the RhoGTPase pathway.
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DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo[a]pyrene.
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DNA adducts and p53 mutations in a patient with aristolochic acid-associated nephropathy.
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DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
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DNA alterations in sporadic colorectal tumors do not correlate with tumor staging diagnosed by the TNM system.
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DNA content and other factors associated with ten-year survival after resection of pancreatic carcinoma.
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DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
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DNA methylation of coding and non-coding regions of the human H-RAS gene in normal and tumor tissues.
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DNA methylation of the CYP1A1 enhancer is associated with smoking-induced genetic alterations in human lung.
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DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients.
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DNA repair: counteragent in mutagenesis and carcinogenesis-- accomplice in cancer therapy resistance.
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Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.
Neoplasms
DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells.
Neoplasms
Does early polypoid colorectal cancer with depression have a pathway other than adenoma-carcinoma sequence?
Neoplasms
Dominant negative Rac1 attenuates paclitaxel-induced apoptosis in human melanoma cells through upregulation of heat shock protein 27: a functional proteomic analysis.
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Dormant Wnt-initiated mammary cancer can participate in reconstituting functional mammary glands.
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Dosage and allelic restriction fragment studies and PCR analysis of the H-ras locus in giant cell tumor of bone.
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Dose-dependent ras mutation spectra in N-nitrosodiethylamine induced mouse liver tumors and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced mouse lung tumors.
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Double cancer of gall bladder and bile duct not associated with anomalous junction of the pancreaticobiliary duct system.
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Down-regulation of let-7 microRNA increased K-ras expression in lung damage induced by radon.
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Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer.
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Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation.
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Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo.
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Downregulation of Rab27A contributes to metformin-induced suppression of breast cancer stem cells.
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Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
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Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
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Downregulation of survivin and aurora a by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy.
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Downregulation of the long noncoding RNA SNHG1 inhibits tumor cell migration and invasion by sponging miR-195 through targeting Cdc42 in oesophageal cancer.
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Downregulation of the Novel Tumor Suppressor DIRAS1 Predicts Poor Prognosis in Esophageal Squamous Cell Carcinoma.
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Dr. Neri et al.: Prognostic role of K-ras mutations in non-small cell lung cancer: Still an issue for open debate.
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DRoP: a water analysis program identifies Ras-GTP-specific pathway of communication between membrane-interacting regions and the active site.
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Dual inhibition of the epidermal growth factor receptor with cetuximab, an IgG1 monoclonal antibody, and gefitinib, a tyrosine kinase inhibitor, in patients with refractory non-small cell lung cancer (NSCLC): a phase I study.
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Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53.
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Ductal neoplasia of the pancreas: nosologic, clinicopathologic, and biologic aspects.
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Dysregulation of Rab37-Mediated Cross-talk between Cancer Cells and Endothelial Cells via Thrombospondin-1 Promotes Tumor Neovasculature and Metastasis.
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Early detection of cancer-associated gene alterations in DNA isolated from rat feces during intestinal tumor-induction with 1,2-dimethylhydrazine.
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Effect of 8-oxoguanine glycosylase deficiency on aflatoxin B1 tumourigenicity in mice.
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Effect of an epidermal growth factor receptor inhibitor in mouse models of lung cancer.
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Effect of early vs. late administration of 4-hydroxyphenylretinamide (4-HPR) on N-methyl-N-nitrosourea (MNU)-induced mammary tumorigenesis.
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Effect of farnesyltransferase inhibitor FTI-276 on established lung adenomas from A/J mice induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
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Effect of K-ras mutation on morphogenesis of colorectal adenomas and early cancers: relationship to distribution of proliferating cells.
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Effect of novel CAAX peptidomimetic farnesyltransferase inhibitor on angiogenesis in vitro and in vivo.
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Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
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Effect of promoter and intron 2 polymorphisms on murine lung K-ras gene expression.
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Effect of Ras-guanine nucleotide release factor 1-mediated H-Ras/ERK signaling pathway on glioma.
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Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.
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Effective panitumumab treatment in patients with heavily pre-treated metastatic colorectal cancer: a case series.
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Effects of 5'-azacytidine and alendronate on a hepatocellular carcinoma cell line: a proteomics perspective.
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Effects of antisense oligonucleotides targeting k-ras expression in pancreatic-cancer cell-lines.
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Effects of asbestiform antigorite on human alveolar epithelial A549 cells: A morphological and immunohistochemical study.
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Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells.
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Effects of silencing Rab27a gene on biological characteristics and chemosensitivity of non-small cell lung cancer.
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Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells.
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Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential.
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Efficacy of Oxaliplatin/5-Fluorouracil/Capecitabine-Cetuximab Combination Therapy and Its Effects on K-Ras Mutations in Advanced Colorectal Cancer.
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EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.
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EGFR and K-ras mutation analysis in non-small cell lung cancer: comparison of paraffin embedded versus frozen specimens.
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EGFR and K-ras mutations along the spectrum of pulmonary epithelial tumors of the lung and elaboration of a combined clinicopathologic and molecular scoring system to predict clinical responsiveness to EGFR inhibitors.
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EGFR autophosphorylation but not protein score correlates with histologic and molecular subtypes in lung adenocarcinoma.
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EGFR Signals Downregulate Tumor Suppressors miR-143 and miR-145 in Western Diet-Promoted Murine Colon Cancer: Role of G1 Regulators.
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EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation.
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Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity.
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Electrospray ionization quadrupole time-of-flight mass spectrometry and quadrupole mass spectrometry for genotyping single nucleotide substitutions in intact polymerase chain reaction products in K-ras and p53.
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Elevated IQGAP1 and CDC42 levels correlate with tumor malignancy of human glioma.
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Elevated K-ras activity with cholestyramine and lovastatin, but not konjac mannan or niacin in lung--importance of mouse strain.
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Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation, migration and resistance to TNF-alpha.
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Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway.
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Endometrial carcinomas with significant mucinous differentiation associated with higher frequency of k-ras mutations: a morphologic and molecular correlation study.
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Enhanced expression of c-myc and H-ras oncogenes in Letterer-Siwe disease. A sequential study using colorimetric in situ hybridization.
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Enhanced expression of EGF receptor and low frequency of ras mutations in X-ray-induced rat thyroid tumours.
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Enhanced expression of Harvey-ras oncogene in FANFT-induced transitional cell carcinoma.
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Enhanced Expression of Rab27A Gene by Breast Cancer Cells Promoting Invasiveness and the Metastasis Potential by Secretion of Insulin-Like Growth Factor-II.
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Enhanced Krev-1 expression inhibits the growth of pancreatic adenocarcinoma cells.
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Enhanced MET Translation and Signaling Sustains K-Ras-Driven Proliferation under Anchorage-Independent Growth Conditions.
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Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides.
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Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
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Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice.
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EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene.
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Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies.
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Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas.
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Epidermal growth factor receptor expression and mutational analysis in synovial sarcomas and malignant peripheral nerve sheath tumors.
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Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer.
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Epidermal Rac1 regulates the DNA damage response and protects from UV-light-induced keratinocyte apoptosis and skin carcinogenesis.
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Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.
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Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.
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Epigenetic lesions causing genetic lesions in human cancer: promoter hypermethylation of DNA repair genes.
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Epigenetic regulation of TGF-?-induced EMT by JMJD3/KDM6B histone H3K27 demethylase.
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Epithelial-to-Mesenchymal Transition and Oncogenic Ras Expression in Resistance to the Protein Kinase C{beta} Inhibitor Enzastaurin in Colon Cancer Cells.
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ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
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Erlotinib for Patients with EGFR Wild-Type Metastatic NSCLC: a Retrospective Biomarkers Analysis.
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Escalating weekly doses of cetuximab and correlation with skin toxicity: A phase I study.
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Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting.
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Establishment and characterization of a human intrahepatic cholangiocarcinoma cell line derived from an Italian patient.
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Establishment and characterization of esophageal squamous cell carcinoma patient-derived xenograft mouse models for preclinical drug discovery.
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Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation.
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Establishment of lung cancer patient-derived xenograft models and primary cell lines for lung cancer study.
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Estimation of risk based on multiple events in radiation carcinogenesis of rat skin.
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Estradiol is trophic for colon cancer in mice: effect on ornithine decarboxylase and c-myc messenger RNA.
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Ets1 was significantly activated by ERK1/2 in mutant K-ras stably transfected human adrenocortical cells.
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Eugenol inhibits oxidative phosphorylation and fatty acid oxidation via downregulation of c-Myc/PGC-1?/ERR? signaling pathway in MCF10A-ras cells.
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Evaluating the treatment of metastatic colorectal cancer with monoclonal antibodies.
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Evaluation of active Rac1 levels in cancer cells: A case of misleading conclusions from immunofluorescence analysis.
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Evaluation of cII mutations in lung of male Big Blue mice exposed by inhalation to vanadium pentoxide for up to 8 weeks.
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Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
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Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models.
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Evaluation of genetic alterations in cancer-related genes in lung and brain tumors from B6C3F1 mice exposed to 1,3-butadiene or chloroprene.
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Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
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Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
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Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.
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Evidence for different expression profiles for c-Met, EGFR, PTEN and the mTOR pathway in low and high grade endometrial carcinomas in a cohort of consecutive women. Occurrence of PIK3CA and K-Ras mutations and microsatellite instability.
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Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma.
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Evidence of Rab3A expression, regulation of vesicle trafficking, and cellular secretion in response to heregulin in mammary epithelial cells.
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Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia.
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Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts.
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Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.
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Evolution and population genetics of the H-ras minisatellite and cancer predisposition.
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Evolution of somatic mutations in mammary tumors in transgenic mice is influenced by the inherited genotype.
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Evolution of telomere maintenance and tumour suppressor mechanisms across mammals.
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Evolutionarily conserved protein ERH controls CENP-E mRNA splicing and is required for the survival of KRAS mutant cancer cells.
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Exercise modulates redox-sensitive small GTPase activity in the brain microvasculature in a model of brain metastasis formation.
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Exosomal miR-2276-5p in Plasma Is a Potential Diagnostic and Prognostic Biomarker in Glioma.
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Experimental, Clinical and Morphological Analysis of H-Ras Oncoproteins for Locally Advanced Breast Cancer.
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Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions.
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Exploring the lapse in druggability: Sequence Analysis, Structural Dynamics and binding site characterization of K-RasG12C variant, a feasible oncotherapeutics target.
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Expression analysis of Cdc42 in lung cancer and modulation of its expression by curcumin in lung cancer cell lines.
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Expression of a Mutant p53 Results in an Age-Related Demographic Shift in Spontaneous Lung Tumor Formation in Transgenic Mice.
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Expression of a transfected v-Harvey-ras oncogene in a Dunning rat prostate adenocarcinoma and the development of high metastatic ability.
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Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis.
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Expression of DJ-1 in endometrial cancer: close correlation with clinicopathological features and apoptosis.
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Expression of epidermal growth factor receptor, but not K-RAS mutations, is present in congenital cystic airway malformation/congenital pulmonary airway malformation.
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Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab.
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Expression of G protein alpha subunits in normal rat colon and in azoxymethane-induced colonic neoplasms.
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Expression of H-ras correlates with metastatic potential: evidence for direct regulation of the metastatic phenotype in 10T1/2 and NIH 3T3 cells.
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Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells.
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Expression of human Krev-1 gene in lungs of transgenic mice and subsequent reduction in multiplicity of ethyl carbamate-induced lung adenomas.
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Expression of Kirsten-ras p21 in gastric cancer correlates with tumor progression and is prognostic.
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Expression of oncogene products HER2/Neu and Ras and fibrosis-related growth factors bFGF, TGF-beta, and PDGF in bile from biliary malignancies and inflammatory disorders.
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Expression of oncogenes and tumor suppressor genes in human hepatocellular carcinoma and hepatoblastoma cell lines.
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Expression of Organic Anion Transporting Polypeptides in an H-Ras 12V Transgenic Mouse Model of Spontaneous Hepatocellular Carcinoma.
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Expression of P21-activated kinase 1 and cell division control protein 42 homolog correlates with clinicopathological features and prognosis in cervical carcinoma.
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Expression of p21ras-related protein in the plasma and tissue of patients with adenomas and carcinomas of the colon.
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Expression of pro-angiogenic factors as potential biomarkers in experimental models of colon cancer.
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Expression of Rap 1 suppresses genomic instability of H-ras transformed mouse fibroblasts.
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Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.
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Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma.
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Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.
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Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.
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Expression of the farnesyltransferase beta-subunit gene in human ovarian carcinoma: correlation to K-ras mutation.
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Expression of the glucocorticoid receptor and K-ras genes in urethan-induced mouse lung tumors and transformed cell lines.
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Expression of the placenta-specific, 100 kDa ras GTPase activating protein in several human cancer cell lines and normal human tissues.
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Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer.
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Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues.
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Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.
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Expression pattern of the PRDX2, RAB1A, RAB1B, RAB5A and RAB25 genes in normal and cancer cervical tissues.
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Expression status and mutational analysis of the ras and B-raf genes in ovarian granulosa cell and epithelial tumors.
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Extended staging results from the detection of isolated tumor cells in the liver of colorectal cancer patients.
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Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system.
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EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-?B-dependent RAP1 transactivation.
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Failure of catalase to protect against aflatoxin B1-induced mouse lung tumorigenicity.
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Familial non-medullary thyroid carcinoma (FNMTC): analysis of fPTC/PRN, NMTC1, MNG1 and TCO susceptibility loci and identification of somatic BRAF and RAS mutations.
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Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies.
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Farnesyltransferase and geranylgeranyltransferase I inhibitors in cancer therapy: important mechanistic and bench to bedside issues.
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Farnesyltransferase inhibitor effects on prostate tumor micro-environment and radiation survival.
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Farnesyltransferase inhibitor SCH-66336 downregulates secretion of matrix proteinases and inhibits carcinoma cell migration.
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Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem.
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Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea.
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Fasudil suppresses fibrosarcoma growth by stimulating secretion of the chemokine CXCL14/BRAK.
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Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
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Feasibility of cetuximab given with a simplified schedule every 2 weeks in advanced colorectal cancer: a multicenter, retrospective analysis.
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Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC.
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Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.
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Fibroblast activation protein-? promotes ovarian cancer cell proliferation and invasion via extracellular and intracellular signaling mechanisms.
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Fibroblast growth factor 2 restrains Ras-driven proliferation of malignant cells by triggering RhoA-mediated senescence.
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Fibroblast-Mediated Collagen Remodeling Within the Tumor Microenvironment Facilitates Progression of Thyroid Cancers Driven by BrafV600E and Pten Loss.
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FilGAP, a GAP protein for Rac, regulates front-rear polarity and tumor cell migration through the ECM.
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Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers.
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Flat-elevated and depressed, subtypes of flat early colorectal cancers, should be distinguished by their pathological features.
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Flexible-body motions of calmodulin and the farnesylated hypervariable region yield a high-affinity interaction enabling K-Ras4B membrane extraction.
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FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion.
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Fluorescence background subtraction technique for hybrid fluorescence molecular tomography/x-ray computed tomography imaging of a mouse model of early stage lung cancer.
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Fluorescence spectroscopy for detection of malignancy: H-ras overexpressing fibroblasts as a model.
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Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
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Formation of benzo[a]pyrene diol epoxide-DNA adducts at specific guanines within K-ras and p53 gene sequences: stable isotope-labeling mass spectrometry approach.
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Formation of extracellular matrix-digesting invadopodia by primary aortic smooth muscle cells.
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Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic Kras(G12D.)
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FRA1 is a determinant for the difference in RAS-induced transformation between human and rat fibroblasts.
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Fragile Histidine Triad Mediated Tumor Suppression of Lung Cancer by Targeting Multiple Components of the Ras/Rho GTPase Molecular Switch.
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Frameshift mutations at mononucleotide repeats in caspase-5 and other target genes in endometrial and gastrointestinal cancer of the microsatellite mutator phenotype.
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Free circulating nucleic acids in plasma and serum (CNAPS) -- Useful for the detection of lung cancer patients?
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Frequency and clinicopathology associations of K-ras mutations in colorectal cancer in a northeast Mexican population.
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Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.
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Frequency of p16(INK4A) alterations and K-ras mutations in intrahepatic cholangiocarcinoma of the liver.
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Frequency of ras mutations in liver neoplasms from B6C3F1 mice exposed to tetrafluoroethylene for two years.
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Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
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Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?
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Frequent c-Ha-ras gene mutations in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
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Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies.
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Frequent detection of K-ras mutation in stool samples of colorectal carcinoma patients after improved DNA extraction: comparison with tissue samples.
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Frequent down-regulation of hRAB37 in metastatic tumor by genetic and epigenetic mechanisms in lung cancer.
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Frequent involvement of ras-signalling pathways in both polypoid-type and flat-type early-stage colorectal cancers.
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Frequent K-ras mutations and absence of p53 mutations in mucin-producing tumors of the pancreas.
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Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice.
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Frequent polymorphic variations but rare tumour specific mutations of the S100A2 on 1q21 in non-small cell lung cancer.
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Frequent polymorphism of peroxisome proliferator activated receptor gamma gene in colorectal cancer containing wild-type K-ras gene.
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Friend leukemia virus integration 1 activates the Rho GTPase pathway and is associated with metastasis in breast cancer.
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From pancreatic intraepithelial neoplasia to cancer: a dramatic progression with K-ras status analysis.
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Function of miR-200a in proliferation and apoptosis of non-small cell lung cancer cells.
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Functional and clinical evidence for NDRG2 as a candidate suppressor of liver cancer metastasis.
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Functional implications of structural predictions for alternative splice proteins expressed in Her2/neu-induced breast cancers.
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Functionalized Graphene@Gold Nanostar/Lipid for Pancreatic Cancer Gene and Photothermal Synergistic Therapy under Photoacoustic/Photothermal Imaging Dual-Modal Guidance.
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Fuzzy modeling and global optimization to predict novel therapeutic targets in cancer cells.
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Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression.
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Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.
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Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons.
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Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity.
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Galectin-3 mediates cross-talk between K-Ras and Let-7c tumor suppressor microRNA.
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Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.
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Galectin-3 regulates a molecular switch from N-Ras to K-Ras usage in human breast carcinoma cells.
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GANT61 plays anti-tumor effects by inducing oxidative stress through miRNA-1286/RAB31 axis in osteosarcoma.
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Garlic extract in bladder cancer prevention: Evidence from T24 bladder cancer cell xenograft model, tissue microarray, and gene network analysis.
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Gastric and intestinal phenotypic marker expression in early differentiated-type tumors of the stomach: clinicopathologic significance and genetic background.
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Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
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Gd-complexes of DTPA-bis(amide) conjugates of tranexamic acid and its esters with high relaxivity and stability for magnetic resonance imaging.
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Gd-EOB-DTPA Enhanced Micro-MR Imaging of Hepatic Tumors in H-ras 12V Transgenic Mice.
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GEF-H1 mediates tumor necrosis factor-alpha-induced Rho activation and myosin phosphorylation: role in the regulation of tubular paracellular permeability.
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Geldanamycin anisimycins activate Rho and stimulate Rho- and ROCK-dependent actin stress fiber formation.
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Gemcitabine and ISIS-2503 for patients with locally advanced or metastatic pancreatic adenocarcinoma: a North Central Cancer Treatment Group phase II trial.
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Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma.
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Gene expression profiling of NMU-induced rat mammary tumors: cross species comparison with human breast cancer.
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Gene expression studies demonstrate that the K-ras/Erk MAP kinase signal transduction pathway and other novel pathways contribute to the pathogenesis of cumene-induced lung tumors.
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Gene-environment interactions in the pre-Industrial Era: the cancer of King Ferrante I of Aragon (1431-1494).
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Gene-modified spontaneous Epstein-Barr virus-transformed lymphoblastoid cell lines as autologous cancer vaccines: mutated p21 ras oncogene as a model.
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Generalizing molecular results arising from incomplete biological samples: expected bias and unexpected findings.
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Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancer.
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Generation and Analysis of Mouse Intestinal Tumors and Organoids Harboring APC and K-Ras Mutations.
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Generation of a ribozyme-adenoviral vector against K-ras mutant human lung cancer cells.
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Generation of Cancerous Neural Stem Cells Forming Glial Tumor by Oncogenic Stimulation.
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Generation of KS-58 as the first K-Ras(G12D)-inhibitory peptide presenting anti-cancer activity in vivo.
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Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas.
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Generation of stable CD4+ and CD8+ T cell lines from patients immunized with ras oncogene-derived peptides reflecting codon 12 mutations.
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Genes are differentially expressed in the epididymal fat of rats rendered obese by a high-fat diet.
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Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
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Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.
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Genetic alterations and growth pattern in biliary duct carcinomas: loss of heterozygosity at chromosome 5q bears a close relation with polypoid growth.
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Genetic alterations detected on chromosomes 13 and 14 in Chinese non-small cell lung carcinomas.
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Genetic alterations in adenoma-carcinoma sequencing of intraductal papillary-mucinous neoplasm of the pancreas.
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Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors.
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Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from B6C3F1 mice exposed to cumene.
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Genetic alterations in K-ras and p53 cancer genes in lung neoplasms from Swiss (CD-1) male mice exposed transplacentally to AZT.
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Genetic alterations in locally advanced stage II/III colon cancer: a search for prognostic markers.
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Genetic alterations in mouse lung tumors: implications for cancer chemoprevention.
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Genetic alterations in ovarian carcinoma: with specific reference to histological subtypes.
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Genetic alterations in p53 and k-ras in lung-cancer in relation to histopathology of the tumor and smoking history of the patient.
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Genetic alterations in the Catnb gene but not the H-ras gene in hepatocellular neoplasms and hepatoblastomas of B6C3F(1) mice following exposure to diethanolamine for 2 years.
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Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.
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Genetic alterations in ulcerative colitis-associated neoplasia focusing on APC, K-ras gene and microsatellite instability.
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Genetic alterations of cancer-related genes in glass fiber-induced transformed cells.
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Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
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Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
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Genetic analysis of H-ras intron-1 polymorphic and variable tandem repeat regions in human breast cancer.
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Genetic analysis of lung tumours of non-smoking subjects: p53 gene mutations are constantly associated with loss of heterozygosity at the FHIT locus.
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Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance.
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Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
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Genetic and cellular changes in colorectal cancer: proposed targets of chemopreventive agents.
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Genetic and clinical features of human pancreatic ductal adenocarcinomas with widespread microsatellite instability.
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Genetic and epigenetic alterations of Ras signalling pathway in colorectal neoplasia: analysis based on tumour clinicopathological features.
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Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice.
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Genetic and epigenetic changes in primary metastatic and nonmetastatic colorectal cancer.
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Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection.
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Genetic and protein markers related to in situ growth and multiplicity in small sporadic colorectal adenomas.
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Genetic changes and histopathological types in colorectal tumors from patients with familial adenomatous polyposis.
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Genetic changes in skin tumor progression: correlation between presence of a mutant ras gene and loss of heterozygosity on mouse chromosome 7.
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Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases.
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Genetic detection of lymph node micrometastases: a selection criterion for liver transplantation in patients with liver metastases after colorectal cancer.
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Genetic determinants of cancer coagulopathy, angiogenesis and disease progression.
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Genetic diagnosis identifies occult lymph node metastases undetectable by the histopathological method.
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Genetic factors in lung disease. Part II: Lung cancer and angiotensin converting enzyme gene.
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Genetic heterogeneity in patients with multiple neoplastic lung lesions: a report of three cases.
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Genetic interaction between Rb and K-ras in the control of differentiation and tumor suppression.
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Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.
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Genetic, epigenetic, and clinicopathologic features of gastric carcinomas with the CpG island methylator phenotype and an association with Epstein-Barr virus.
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Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.
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Genome-wide analysis of chromosomal alterations in patients with esophageal squamous cell carcinoma exposed to tobacco and betel quid from high-risk area in India.
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Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway.
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Genomic alterations in sarcomas: a histologic correlative study with use of oncogene panels.
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Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras.
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Genomic instability, as measured by microsatellite alterations, is not associated with liver tumor development in the genetically susceptible B6C3F1 mouse.
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Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization.
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Genotyping of K-ras codons 12 and 13 mutations in colorectal cancer by capillary electrophoresis.
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Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
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Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane association and activation.
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GFAP-Cre-Mediated Activation of Oncogenic K-ras Results in Expansion of the Subventricular Zone and Infiltrating Glioma.
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GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/iron are consistent with oxidative damage to DNA.
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GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer.
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Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility.
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Glucocorticoid and estrogen receptors have elevated activity in human endometrial and ovarian tumors as compared to the adjacent normal tissues and recognize sequence elements of the H-ras proto-oncogene.
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Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
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Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis.
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Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response.
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Glucose-6-Phosphate Dehydrogenase Is Not Essential for K-Ras-Driven Tumor Growth or Metastasis.
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Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.
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Glutathione S-transferase mu1 null genotype is associated with K-ras gene mutation in lung adenocarcinoma among smokers.
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GNA11 and N-RAS mutations: alternatives for MAPK pathway activating GNAQ mutations in primary melanocytic tumours of the central nervous system.
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Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells.
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Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes.
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Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt.
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GSTM1, P53 and K-ras molecular detection in resectable non-small cell lung cancer by denaturing gradient gel electrophoresis-bronchoalveolar lavage fluid analysis.
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GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.
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GTPases Rho distribution in intraepithelial and invasive neoplasias of the uterine cervix.
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Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
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Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.
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H- and K-ras mutational profiles in chemically induced liver tumors from B6C3F1 and CD-1 mice.
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H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
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H-ras activation and ras p21 expression in bladder tumors induced in F344/NCr rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
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H-ras activation in benign and self-regressing skin tumors (keratoacanthomas) in both humans and an animal model system.
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H-ras activation is an early event in the ptaquiloside-induced carcinogenesis: comparison of acute and chronic toxicity in rats.
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H-ras and c-fos exhibit similar expression patterns during most stages of oral oncogenesis.
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H-ras and K-ras gene mutations in primary human soft tissue sarcoma: concomitant mutations of the ras genes.
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H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences.
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H-ras and Nm23-H1 gene expression and proteolytic activity in squamous cell carcinoma of the uterine cervix.
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H-ras Consensus Sequence and Mutations in Primary Hepatocellular Carcinomas of Lemurs and Lorises.
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H-ras gene amplification or mutation is not common in human primary breast cancer.
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H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases.
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H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series.
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H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
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H-ras oncogene activation in invasive UVR-induced corneal sarcomas of the opossum Monodelphis domestica.
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H-ras oncogene mutation in dedifferentiated liposarcoma. Polymerase chain reaction-restriction fragment length polymorphism analysis.
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H-ras oncogene mutation spectra in B6C3F1 and C57BL/6 mouse liver tumors provide evidence for TCDD promotion of spontaneous and vinyl carbamate-initiated liver cells.
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H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer.
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H-ras oncogene mutations in the urine of patients with bladder-tumors - description of a noninvasive method for the detection of neoplasia.
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H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts.
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H-ras-1 gene mutations in basal cell carcinoma: automated direct sequencing of clinical specimens.
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H-Ras-driven tumoral maintenance is sustained through caveolin-1-dependent alterations in calcium signaling.
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H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis.
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Harnessing membrane trafficking to promote cancer spreading and invasion: The case of RAB2A.
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Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.
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HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS.
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Heparin co-factor II enhances cell motility and promotes metastasis in non-small cell lung cancer.
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Hepatic disseminated tumor cells in colorectal cancer UICC stage 4 patients: prognostic implications.
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Hepatic tumors induced by carbon tetrachloride in transgenic mice carrying a human c-H-ras proto-oncogene without mutations.
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Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42.
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Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype.
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Hepatocarcinogenicity of chlordane in B6C3F1 and B6D2F1 male mice: evidence for regression in B6C3F1 mice and carcinogenesis independent of ras proto-oncogene activation.
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Hepatocyte expression of tumor associated aldehyde dehydrogenase (ALDH-3) and p21 Ras following diethylnitrosamine (DEN) initiation and chronic exposure to di(2-ethylhexyl)phthalate (DHEP).
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Heterogeneity of DNA methylation status analyzed by bisulfite-PCR-SSCP and correlation with clinico-pathological characteristics in colorectal cancer.
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Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy.
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Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology.
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Heterogeneous genetic alterations in ovarian mucinous tumors: application and usefulness of laser capture microdissection.
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Heterozygous inactivation of TGF-beta1 increases the susceptibility to chemically induced mouse lung tumorigenesis independently of mutational activation of K-ras.
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High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors.
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High Expression of Cell Division Cycle 42 Promotes Pancreatic Cancer Growth and Predicts Poor Outcome of Pancreatic Cancer Patients.
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High expression of Rap2A is associated with poor prognosis of patients with hepatocellular carcinoma.
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High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway.
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High expression of small GTPase Rab3D promotes cancer progression and metastasis.
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High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India.
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High frequency of activated K-ras codon 15 mutant in colorectal carcinomas from Taiwanese patients.
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High Frequency of Codon 12 but not Codon 13 and 61 K-ras Gene Mutations in Invasive Ductal Carcinoma of Breast in a South Indian Population.
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High frequency of codon 61 K-ras A-->T transversions in lung and Harderian gland neoplasms of B6C3F1 mice exposed to chloroprene (2-chloro-1,3-butadiene) for 2 years, and comparisons with the structurally related chemicals isoprene and 1,3-butadiene.
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High frequency of K-ras mutations in normal appearing lung tissues and sputum of patients with lung cancer.
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High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice.
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High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
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High incidence of H-ras oncogene mutations in squamous cell carcinoma of lip vermilion.
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High incidence of point mutation in K-ras codon 12 in carcinoma of the fallopian tube.
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High level of galectin-1 expression is a negative prognostic predictor of recurrence in laryngeal squamous cell carcinomas.
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High levels of c-myc protein in human breast tumours determined by a sensitive ELISA technique.
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High Levels of Cell-Free Circulating Nucleic Acids in Pancreatic Cancer are Associated With Vascular Encasement, Metastasis and Poor Survival.
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High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.
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High-Affinity Interaction of the K-Ras4B Hypervariable Region with the Ras Active Site.
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High-degree tumor budding and podia-formation in sporadic colorectal carcinomas with K-ras gene mutations.
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High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma.
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High-level microsatellite instability is not involved in gallbladder carcinogenesis.
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High-throughput amenable fluorescence-assays to screen for calmodulin-inhibitors.
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High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
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Higher expression of K-ras is associated with parathyroid hormone-related protein-induced hypercalcaemia in renal cell carcinoma.
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Histamine receptors signalling in epidermal tumor cell lines with H-ras gene alterations.
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Histochemical characterization of non-neuroendocrine tumors and neuroendocrine cell hyperplasia induced in hamster lung by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone with or without hyperoxia.
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Histogenesis and the role of p53 and K-ras mutations in hepatocarcinogenesis by glyceryl trinitrate (nitroglycerin) in male F344 rats.
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Histological and genetic changes in malignant transformation of gallbladder adenoma.
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Histone deacetylase 1 represses the small GTPase RhoB expression in human nonsmall lung carcinoma cell line.
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Histopathology of salivary and mammary gland tumors in transgenic mice expressing a human Ha-ras oncogene.
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HIV protease inhibitors block Akt signaling and radiosensitize tumor cells both in vitro and in vivo.
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Hormone dependent and independent mammary tumor development form N-methyl-N-nitrosourea-treated rat mammary epithelial cell xenografts in the nude mouse: multiple pathways and H-ras activation.
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Hsa-miR-1 suppresses breast cancer development by down-regulating K-ras and long non-coding RNA MALAT1.
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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.
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Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.
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Human urine contains small, 150 to 250 nucleotide-sized, soluble DNA derived from the circulation and may be useful in the detection of colorectal cancer.
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Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.
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Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression.
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Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
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Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.
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Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification.
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Hypermethylation of CpG island in O6-methylguanine-DNA methyltransferase gene was associated with K-ras G to A mutation in colorectal tumor.
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Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status.
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Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion.
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Hypoxia promotes Rab5 activation, leading to tumor cell migration, invasion and metastasis.
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Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the alpha6beta4 integrin.
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Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin ?v?3/FAK/PI3K pathway-mediated Rac1 activation.
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Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5.
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Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer.
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Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro.
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Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform.
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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
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Identification of a farnesol analog as a Ras function inhibitor using both an in vivo Ras activation sensor and a phenotypic screening approach.
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Identification of a MET-eIF4G1 translational regulation axis that controls HIF-1? levels under hypoxia.
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Identification of a metabolic and canonical biomarker signature in Mexican HR+/HER2-, triple positive and triple-negative breast cancer patients.
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Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
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Identification of cancer-associated missense mutations in hace1 that impair cell growth control and Rac1 ubiquitylation.
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Identification of Differentially Expressed Genes in Papillary Thyroid Carcinomas With and Without Rearrangements of the Tyrosine Kinase Receptors RET and/or NTRK1.
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Identification of Gene Loci That Overlap Between Mental Disorders and Poor Prognosis of Cancers.
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Identification of genetic polymorphisms through comparative DNA sequence analysis on the K-ras gene: implications for lung tumor susceptibility.
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Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors.
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Identification of h-ras-specific motif for the activation of invasive signaling program in human breast epithelial cells.
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Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses.
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Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma.
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Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer.
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Identification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles.
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Identification of lung micrometastatic tumor foci in nude mice with implanted tumor using laser capture microdissection and PCR-single-strand conformation polymorphism.
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Identification of mutant K-Ras-dependent phenotypes using a panel of isogenic cell lines.
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Identification of overlapping epitopes in mutant ras oncogene peptides that activate CD4+ and CD8+ T cell responses.
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Identification of P-Rex1 in the Regulation of Liver Cancer Cell Proliferation and Migration via HGF/c-Met/Akt Pathway.
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Identification of pharmacokinetically stable 3, 10-dibromo-8-chlorobenzocycloheptapyridine farnesyl protein transferase inhibitors with potent enzyme and cellular activities.
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Identification of Rab27a as a host factor for oncolytic herpes virus susceptibility to tumor cells.
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Identification of Rab6a as a New Target of microRNA-155 Involved in Regulating Lipopolysaccharide-Induced TNF Secretion.
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Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.
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Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.
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Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation.
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Identification of secreted proteins that mediate cell-cell interactions in an in vitro model of the lung cancer microenvironment.
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Identification of subjects at risk for colorectal carcinoma through a test based on K-ras determination in the stool.
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Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling.
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Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma.
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Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses.
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Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells.
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Illuminating Radiogenomic Characteristics of Glioblastoma Multiforme through Integration of MR Imaging, Messenger RNA Expression, and DNA Copy Number Variation.
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Immortalized bovine pancreatic duct cells become tumorigenic after transfection with mutant k-ras.
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Immunocytochemical analysis of the synaptic proteins SNAP-25 and Rab3A in human pituitary adenomas. Overexpression of SNAP-25 in the mammmosomatotroph lineages.
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Immunocytochemical demonstration and significance of p21 ras family oncogene product in benign and malignant breast disease.
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Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum.
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Immunocytochemical localization of p21 ras gene product in human hepatoma cell lines and corresponding tumors in athymic mice.
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Immunocytochemically detectable TGF-beta associated with malignancy in thyroid epithelial neoplasia.
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Immunogenicity of Del19 EGFR mutations in Chinese patients affected by lung adenocarcinoma.
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Immunohistochemical analysis of MIB-1 proliferative activity in human endometrial cancer. Correlation with clinicopathological parameters, patient outcome, retinoblastoma immunoreactivity and K-ras codon 12 point mutations.
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Immunohistochemical analysis reveals a protective effect of H-ras expression mediated via apoptosis in node-negative breast cancer patients.
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Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
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Immunohistochemical and genetic analysis of osteoclastic giant cell tumor of the pancreas.
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Immunohistochemical and molecular features of primary clear cell-adenocarcinoma of the rectum, as predictive factors for individualized therapy.
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Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas.
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Immunohistochemical detection of the H-ras, K-ras, and N-ras oncogenes in squamous cell carcinoma of the head and neck.
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Immunohistochemical evaluation of P21ras and P53 proteins expression in human non-small-cell lung cancers.
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Immunohistochemical expression of rabphilin-3A-like (Noc2) in normal and tumor tissues of human endocrine pancreas.
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Immunohistochemical localization of telomerase hTERT protein and analysis of clonality in multifocal vulvar intraepithelial neoplasia.
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Immunohistochemical studies of colorectal cancers that developed following pelvic irradiation.
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Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras.
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Immunophenotype and K-RAS mutation in mucinous ovarian adenocarcinoma with mural nodule of high-grade sarcoma: case report.
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Immunophenotype of mutant ras p21 and early response to radiotherapy in cancer of the uterine cervix.
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Immunophenotype, ras oncogenes and p53 onco-suppressor gene in benzo(a)pyrene induced malignant soft tissue tumours in Wistar rats.
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Immunoprevention of Chemical Carcinogenesis through Early Recognition of Oncogene Mutations.
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IMP-1 Displays Cross-Talk with K-Ras and Modulates Colon Cancer Cell Survival through the Novel Proapoptotic Protein CYFIP2.
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Impact of Cadmium on Intracellular Zinc Levels in HepG2 Cells: Quantitative Evaluations and Molecular Effects.
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Impact of Nrf2 on tumour growth and drug sensitivity in oncogenic K-ras-transformed cells in vitro and in vivo.
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Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells.
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Impact of oncogenic driver mutations on feedback between the PI3K and MEK pathways in cancer cells.
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Implication of K-ras and p53 in colorectal cancer carcinogenesis in Tunisian population cohort.
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Implications and prognostic value of K-ras mutation for early-stage lung cancer in women.
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Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.
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In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction.
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In Systemic Sclerosis, a Unique Long Non Coding RNA Regulates Genes and Pathways Involved in the Three Main Features of the Disease (Vasculopathy, Fibrosis and Autoimmunity) and in Carcinogenesis.
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In tumor cells regulation of DNA double strand break repair through EGF receptor involves both NHEJ and HR and is independent of p53 and K-Ras status.
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In vitro carcinogenesis of hamster pancreatic duct cells: cellular and molecular alterations.
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In vitro transformation of mesenchymal stem cells induces gradual genomic hypomethylation.
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In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia.
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In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer.
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In-silico identification of small molecules targeting H-Ras and in-vitro cytotoxicity with caspase-mediated apoptosis in carcinoma cells.
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Inactivation of p16INK4a by CpG hypermethylation is not a frequent event in colorectal cancer.
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Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
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Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
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Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.
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Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung.
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Incidence of Harvey ras oncogene point mutations and their expression in methylbenzylnitrosamine-induced esophageal tumorigenesis.
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Increase in the frequency of K-ras codon 12 point mutation in colorectal carcinoma in elderly males in Japan: the 1990s compared with the 1960s.
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Increased cyclin D1 expression in cancer of the ampulla of Vater: relevance to nuclear beta catenin accumulation and k-ras gene mutation.
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Increased epidermal growth factor receptor (EGFR) gene copy number is strongly associated with EGFR mutations and adenocarcinoma in non-small cell lung cancers: a chromogenic in situ hybridization study of 182 patients.
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Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis.
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Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia.
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Increased farnesyltransferase activity in human colorectal cancer: relationship with clinicopathological features and K-ras mutation.
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Increased frequency of K-ras mutations in lung neoplasms from female B6C3F1 mice exposed to ozone for 24 or 30 months.
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Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.
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Increased H-ras mutation frequency in mammary tumors of rats initiated with N-methyl-N-nitrosourea (MNU) and treated with acrylamide.
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Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
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Increased K-ras mutation and expression of S100A4 and MUC2 protein in the malignant intraductal papillary mucinous tumor of the pancreas.
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Increased Occurrence of Caspase-Dependent Apoptosis in Unfavorable Neuroblastomas.
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Increased Rac1 activity and Pak1 overexpression are associated with lymphovascular invasion and lymph node metastasis of upper urinary tract cancer.
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Increased radioresistance via G12S K-Ras by compensatory upregulation of MAPK and PI3K pathways in epithelial cancer.
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Increased regucalcin gene expression extends survival in breast cancer patients: Overexpression of regucalcin suppresses the proliferation and metastatic bone activity in MDA-MB-231 human breast cancer cells in vitro.
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Individual and combined soy isoflavones exert differential effects on metastatic cancer progression.
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Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.
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Inducible activation of oncogenic K-ras results in tumor formation in the oral cavity.
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Inducible transgenics. New lessons on events governing the induction and commitment in mammary tumorigenesis.
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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes.
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Induction of apoptosis and inhibition of papilloma formation may signal a new role for okadaic acid.
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Induction of CTLs by DCs pulsed with K-ras mutant peptide on the surface of nanoparticles in the treatment of pancreatic cancer.
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Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.
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Induction of esophageal tumors in zinc-deficient rats by single low doses of N-nitrosomethylbenzylamine (NMBA): analysis of cell proliferation, and mutations in H-ras and p53 genes.
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Induction of invasive mouse skin carcinomas in transgenic mice with mutations in both H-ras and p53.
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Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes.
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Induction of mammary cancer and lymphoma by multiple, low oral doses of 7,12-dimethylbenz[a]anthracene in SENCAR mice.
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Induction of ovarian cancer by defined multiple genetic changes in a mouse model system.
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Induction of potent cell growth inhibition by schizophyllan/K-ras antisense complex in combination with gemcitabine.
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Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
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Ineffectiveness of the presence of H-ras/p53 combination of mutations in squamous cell carcinoma cells to induce a conversion of a nontumorigenic to a tumorigenic phenotype.
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Influence of retrovirally transduced human tumor-necrosis-factor-alpha on the expression of C-myc, k-ras, C-jun, p53, tgf-alpha, and cea in human colon-carcinoma cell-lines.
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Influence of sex and carcinogen treatment protocol on tumor latency and frequency of K-ras mutations in N-methyl-N-nitrosourea-induced lymphomas.
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Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
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Infrequent involvement of mutations on neurofibromatosis type 1, H-ras, K-ras and N-ras in urothelial tumors.
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Infrequent K-ras activation in superficial-type (flat) colorectal adenomas and adenocarcinomas.
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Infrequent mutation of the ras genes in skin tumors of xeroderma pigmentosum patients in Japan.
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Ingenuity in pattern recognition: a novel bioinformatics approach towards lung cancer identification.
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Inhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
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Inhibiting Ras prenylation increases the radiosensitivity of human tumor cell lines with activating mutations of ras oncogenes.
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Inhibition effects of Yuxiao San combined with cisplatin on transplanted tumor growths via upregulation of nm-23 and downregulation of K-ras in Lewis lung cancer mice.
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Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.
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Inhibition of Calcineurin/NFAT Signaling Blocks Oncogenic H-Ras Induced Autophagy in Primary Human Keratinocytes.
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Inhibition of cancer cell invasion by new ((3,4-dihydroxy benzylidene)hydrazinyl)pyridine-3-sulfonamide analogs.
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Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.
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Inhibition of Cdc42 is essential for Mig-6 suppression of cell migration induced by EGF.
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Inhibition of CDC42 reduces macrophage recruitment and suppresses lung tumorigenesis in vivo.
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Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth.
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Inhibition of cell proliferation and metastasis of human hepatocellular carcinoma by miR-137 is regulated by CDC42.
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Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment.
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Inhibition of ChoK is an efficient antitumor strategy for Harvey-, Kirsten-, and N-ras-transformed cells.
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Inhibition of COX-2 and induction of apoptosis: two determinants of nonsteroidal anti-inflammatory drugs' chemopreventive efficacies in mouse lung tumorigenesis.
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Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester.
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Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression.
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Inhibition of endothelial cell proliferation by targeting Rac1 GTPase with small interference RNA in tumor cells.
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Inhibition of farnesyl protein transferase and P21ras memebrane association by d-limonene in human pancreas tumor cells in vitro.
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Inhibition of farnesyltransferase with A-176120, a novel and potent farnesyl pyrophosphate analogue.
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Inhibition of fascin in cancer and stromal cells blocks ovarian cancer metastasis.
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Inhibition of gastric cancer cell growth and invasion through siRNA-mediated knockdown of guanine nucleotide exchange factor Vav3.
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Inhibition of HMGcoA reductase by atorvastatin prevents and reverses MYC-induced lymphomagenesis.
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Inhibition of human bladder cancer cell motility by genistein is dependent on epidermal growth factor receptor but not p21ras gene expression.
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Inhibition of lung tumor cell growth in vitro and mouse lung tumor formation by lovastatin.
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Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors.
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Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras.
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Inhibition of miR-193a Expression by Max and RXR{alpha} Activates K-Ras and PLAU to Mediate Distinct Aspects of Cellular Transformation.
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Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase.
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Inhibition of mutant KRAS-driven overexpression of ARF6 and MYC by an eIF4A inhibitor drug improves the effects of anti-PD-1 immunotherapy for pancreatic cancer.
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Inhibition of NRAS Signaling in Melanoma through Direct Depalmitoylation Using Amphiphilic Nucleophiles.
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Inhibition of O(6)-methylguanine-DNA methyltransferase increases azoxymethane-induced colonic tumors in rats.
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Inhibition of RAC1 activity in cancer associated fibroblasts favours breast tumour development through IL-1? upregulation.
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Inhibition of Rac1 GTPase downregulates vascular endothelial growth factor receptor-2 expression by suppressing Sp1-dependent DNA binding in human endothelial cells.
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Inhibition of Rac1 reverses enzalutamide resistance in castration-resistant prostate cancer.
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Inhibition of rat colon tumors by sulindac and sulindac sulfone is independent of K-ras (codon 12) mutation.
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Inhibition of redox/Fyn/c-Cbl pathway function by Cdc42 controls tumour initiation capacity and tamoxifen sensitivity in basal-like breast cancer cells.
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Inhibition of the membrane localization of p21 ras proteins by lovastatin in tumor cells possessing a mutated N-ras gene.
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Inhibition of the miR-192/215-Rab11-FIP2 axis suppresses human gastric cancer progression.
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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
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Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer.
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Inhibition of tumor cell migration and metastasis by the proton-sensing GPR4 receptor.
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Inhibition of tumor growth by S-3-1, a synthetic intermediate of salvianolic acid A.
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Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLC?/PKC? Signaling Pathway.
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Inhibitors of chronically active ras: potential for treatment of human malignancies.
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Inhibitors of farnesyl protein transferase and MEK1,2 induce apoptosis in fibroblasts transformed with farnesylated but not geranylgeranylated H-Ras.
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Inhibitors of the ROCK serine/threonine kinases: key effectors of the RhoA small GTPase.
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Inhibitory effect of sarcophytol A on pancreatic carcinogenesis after initiation by N-nitrosobis(2-oxypropyl)amine in Syrian hamsters.
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Inhibitory effects of compound DMBT on hypoxia-induced vasculogenic mimicry in human breast cancer.
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Inhibitory effects of phenolic alkaloids of menispermum dauricum on gastric cancer in vivo.
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Inositol Trisphosphate Receptor Type 3-mediated Enhancement of EGFR and MET Cotargeting Efficacy in Non-Small Cell Lung Cancer Detected by 18F-fluorothymidine.
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Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain.
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Insulin like growth factor-1 selectively regulates the expression of matrix metalloproteinase-2 in malignant H-ras transformed cells.
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Insulin-like growth factor 1 expression correlates with clinical outcome in K-RAS wild type colorectal cancer patients treated with cetuximab and irinotecan.
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Insulin-like growth factor receptor-1 expression predicts postoperative recurrence in adenocarcinoma of the lung.
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Insulin-mediated alterations in S-adenosylmethionine decarboxylase expression in H-ras transformed cells of varying degrees of malignancy.
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Integrated analysis identifies a long non-coding RNAs-messenger RNAs signature for prediction of prognosis in hepatitis B virus-hepatocellular carcinoma patients.
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Integrated genomic and pharmacological approaches to identify synthetic lethal genes as cancer therapeutic targets.
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Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.
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Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.
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Integrative transcriptional analysis between human and mouse cancer cells provides a common set of transformation associated genes.
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Integrin-Induced Signal Event Contributes to Self-Assembled Monolayers on Au-Nanoparticle-Regulated Cancer Cell Migration and Invasion.
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Integrin?1 modulates tumour resistance to gemcitabine and serves as an independent prognostic factor in pancreatic adenocarcinomas.
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Interactions of chemical carcinogens and genetic variation in hepatocellular carcinoma.
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Interlaboratory comparison of K-ras testing by real-time PCR and RFLP in colorectal cancer samples.
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Interleukin-10-deficient mice and inflammatory bowel disease associated cancer development.
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Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer.
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Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.
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Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and recycling.
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Interrelationship between the expression of h-ras p21, C-myc and p53 proteins, and the infection of high-risk human papillomaviruses in Japanese patients with esophageal squamous-cell carcinoma.
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Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).
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Intervention of human breast cell carcinogenesis chronically induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.
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Intracellular expression and functional properties of an anti-p21Ras scFv derived from a rat hybridoma containing specific lambda and irrelevant kappa light chains.
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Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression.
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Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
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Intraductal Tubulopapillary Epithelial Proliferation Associated with Type 1 Autoimmune Pancreatitis.
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Intratumor cellular heterogeneity and alterations in ras oncogene and p53 tumor suppressor gene in human prostate carcinoma.
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Intratumor heterogeneity of k-ras and p53 mutations among human colorectal adenomas containing early cancer.
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Intravenous infusion of bone marrow mononuclear cells promotes functional recovery and improves impaired cognitive function via inhibition of Rho guanine nucleotide triphosphatases and inflammatory signals in a model of chronic epilepsy.
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Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions.
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Introduction of wild-type p53 gene downregulates the expression of H-ras gene and suppresses the growth of bladder cancer cells.
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Invasion inhibition in pancreatic cancer using the oral iron chelating agent deferasirox.
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Invasive cancer and survival of intraductal papillary mucinous tumors of the pancreas.
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Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer.
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Investigating the role of ADP-ribosylation factor 6 in tumor cell invasion and extracellular signal-regulated kinase activation.
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Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.
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Investigation of GTP-dependent dimerization of G12X K-Ras variants using ultraviolet photodissociation mass spectrometry.
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Investigation of the pharmacological profiles of dinuclear metal complexes as novel, potent and selective cytotoxic agents against ras-transformed cells.
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Involvement of E-cadherin, beta-catenin, Cdc42 and CXCR4 in the progression and prognosis of cutaneous melanoma.
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Involvement of K-RAS mutations and amino acid substitutions in the survival of metastatic colorectal cancer patients.
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Involvement of Kruppel-like factor 6 (KLF6) mutation in the development of nonpolypoid colorectal carcinoma.
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Involvement of Rho family GTPases in p19Arf- and p53-mediated proliferation of primary mouse embryonic fibroblasts.
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Involvement of small ArfGAP1 (SMAP1), a novel Arf6-specific GTPase-activating protein, in microsatellite instability oncogenesis.
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Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
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Irinotecan hydrochloride (CPT-11) resistance identified by K-ras mutation in patients with progressive colon cancer after treatment with 5-fluorouracil (5-FU).
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IRSp53 coordinates AMPK and 14-3-3 signaling to regulate filopodia dynamics and directed cell migration.
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Is availability of anti-EGFR therapy for the colorectal adenocarcinomas showing fascin expression limited?
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Is primary sidedness a prognostic factor in patients with resected colon cancer liver metastases (CLM)?
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Is the Effect of Tumor Localization on Prognosis Compatible with Real-life Data in Metastatic Colon Cancer? Single-Center Experience: A Retrospective Analysis.
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Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression.
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Isoform specific gene expression analysis of KRAS in the prognosis of lung adenocarcinoma patients.
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Isogambogenic acid inhibits tumour angiogenesis by suppressing Rho GTPases and vascular endothelial growth factor receptor 2 signalling pathway.
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Isolated Hepatic Perfusion with High-Dose Melphalan Results in Immediate Alterations in Tumor Gene Expression in Patients with Metastatic Ocular Melanoma.
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Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
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Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.
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K-ras 4A and 4B are co-expressed widely in human tissues, and their ratio is altered in sporadic colorectal cancer.
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K-ras 4A and 4B mRNA levels correlate with superoxide in lung adenocarcinoma cells, while at the protein level, only mutant K-ras 4A protein correlates with superoxide.
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K-ras activation and ras p21 expression in latent prostatic carcinoma in Japanese men.
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K-ras activation in premalignant and malignant epithelial lesions of the human uterus.
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K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary.
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K-ras alterations in Danish ovarian tumour patients. From the Danish "Malova" Ovarian Cancer study.
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K-ras and B-raf gene mutations are not associated with gastrin- and CCK2-receptor mRNA expression in human colorectal tumour tissues.
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K-Ras and cyclooxygenase-2 coactivation augments intraductal papillary mucinous neoplasm and Notch1 mimicking human pancreas lesions.
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K-Ras and its inhibitors towards personalized cancer treatment: Pharmacological and structural perspectives.
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K-Ras and microsatellite marker analysis of fine-needle aspirates from intraductal papillary mucinous neoplasms of the pancreas.
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K-ras and p16(INK4A)alterations in sputum of NSCLC patients and in heavy asymptomatic chronic smokers.
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K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
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K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study.
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K-ras and p53 mutations and overexpressions as prognostic factors in female rectal carcinoma.
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K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.
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K-RAS and P53 mutations in association with COX-2 and hTERT expression and clinico-pathological status of NSCLC patients.
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K-ras and p53 mutations in colonic lavage fluid of patients with colorectal neoplasias.
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K-ras and p53 mutations in DNA extracted from colonic epithelial cells exfoliated in faeces of patients with colorectal cancer.
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K-ras and p53 mutations in hamster pancreatic ductal adenocarcinomas and cell lines.
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K-ras and p53 mutations in stage I gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct.
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K-ras and p53 mutations in the pathogenesis of classical and goblet cell carcinoids of the appendix.
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K-ras and p53 point mutations in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced hamster lung tumors.
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K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.
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K-ras cancer gene mutations in lung tumors from female Swiss (CD-1) mice exposed transplacentally to 3'-azido-3'-deoxythymidine.
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K-ras codon 12 and 13 mutations are correlated with differential patterns of tumor cell dissemination in colorectal cancer patients.
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K-ras codon 12 and 61 point mutations in bromodeoxyuridine- and N-nitrosomethylurea-induced rat renal mesenchymal tumors.
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K-ras codon 12 and p53 mutations in biopsy specimens and bile from biliary tract cancers.
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K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.
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K-ras codon 12 mutations detected with enriched PCR method in operable non-small cell lung cancer.
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K-ras codon 12 mutations in biliary tract tumors detected by polymerase chain reaction denaturing gradient gel electrophoresis.
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K-ras codon 12 mutations may be detected in serum of patients suffering from adeno- and large cell lung carcinoma. A preliminary report.
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K-ras codon 12 mutations of the super-minute dysplasia in Barrett's esophagus by DNA extraction using a microdissection method.
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K-ras exon 4A has a tumour suppressor effect on carcinogen-induced murine colonic adenoma formation.
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K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.
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K-ras gene mutation in the diagnosis of ultrasound guided fine-needle biopsy of pancreatic masses.
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K-Ras gene mutation status as a prognostic and predictive factor in patients with colorectal cancer undergoing irinotecan- or oxaliplatin-based chemotherapy.
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K-ras gene mutational analysis supports a monoclonal origin of biphasic pleomorphic carcinoma of the lung.
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K-ras gene mutations and loss of heterozygosity at the p53 gene locus relative to histological characteristics of mucin-producing tumors of the pancreas.
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K-ras gene mutations in early colorectal cancer ... flat elevated vs polyp-forming cancer....
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K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients.
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K-ras gene mutations: an unfavorable prognostic marker in stage I lung adenocarcinoma.
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K-ras gene point mutation: a stable tumor marker in non-small cell lung carcinoma.
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K-ras gene point mutations in human endometrial carcinomas: correlation with clinicopathological features and patients' outcome.
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K-ras genetic mutation and influencing factor analysis for Han and Uygur nationality colorectal cancer patients.
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K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
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K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
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K-RAS Mutant Pancreatic Tumors Show Higher Sensitivity to MEK than to PI3K Inhibition In Vivo.
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K-RAS mutation analysis in a case of pancreatic cystic tumour: an additional tool in making decision of surgical management.
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K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines.
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K-ras mutation and loss of heterozygosity of chromosome 17p and survival in colorectal cancer.
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K-ras mutation and loss of heterozygosity of the adenomatous polyposis coli gene in patients with colorectal adenomas with in situ carcinoma.
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k-ras mutation and occupational asbestos exposure in lung adenocarcinoma: asbestos-related cancer without asbestosis.
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K-ras mutation and p53 protein accumulation in intraductal mucin-hypersecreting neoplasms of the pancreas.
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k-RAS mutation and resistance to epidermal growth factor receptor-tyrosine kinase inhibitor treatment in patients with nonsmall cell lung cancer.
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K-ras mutation detection in colorectal cancer using the Pyrosequencing technique.
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K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis.
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K-ras mutation in a tubular adenoma originating at an ileostomy in a familial adenomatous polyposis patient.
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K-ras mutation in colorectal cancer: relations to patient age, sex and tumour location.
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K-ras mutation in Greek patients with poorly and moderately differenciated tumours of the lower intestinal tract.
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K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
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K-Ras mutation in liquid biopsy and tumor tissue correlation in patients with pancreatic cancer.
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K-RAS mutation profile in Puerto Rican patients with colorectal cancer: trends from April 2009 to January 2011.
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K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
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K-ras mutation status correlates with the expression of VEGFR1, VEGFR2, and PDGFRalpha in colorectal cancer.
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K-ras Mutation Targeted to Gastric Tissue Progenitor Cells Results in Chronic Inflammation, an Altered Microenvironment, and Progression to Intraepithelial Neoplasia.
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K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China.
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K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
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K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
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K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
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K-ras mutations (codon 12) are not involved in down-regulation of MHC class-I genes in colon carcinomas.
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K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
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K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix.
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K-ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-dimethylhydrazine.
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K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis.
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K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy.
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K-ras mutations appear in the premalignant phase of both microsatellite stable and unstable endometrial carcinogenesis.
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K-ras mutations are a relatively late event in the pathogenesis of lung carcinomas.
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K-ras mutations are correlated to lymph node metastasis and tumor stage, but not to the growth pattern of colon carcinoma.
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K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer.
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K-ras mutations are frequent in pulmonary squamous cell carcinomas but not in adenocarcinomas of WBN/Kob rats induced by N-nitrosobis(2-oxopropyl)amine.
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K-ras Mutations Correlate with Atypical Cytology and Elevated CEA Levels in Pancreatic Cystic Neoplasms.
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K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
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K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.
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K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
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K-ras mutations in duodenal aspirate without secretin stimulation for screening of pancreatic and biliary tract carcinoma.
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K-ras mutations in gastric stump carcinomas and in carcinomas from the non-operated stomach.
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K-ras mutations in human adenocarcinoma of the lung: association with smoking and occupational exposure to asbestos.
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K-ras mutations in lung carcinomas from nonsmoking women exposed to unvented coal smoke in China.
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K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
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K-ras mutations in lung tumors from A/J and A/J x TSG-p53 F1 mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and phenethyl isothiocyanate.
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K-ras Mutations in Lung Tumors from NNK-treated Mice with Lipopolysaccharide-elicited Lung Inflammation.
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K-ras mutations in Müllerian inclusion cysts associated with serous borderline tumors of the ovary.
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K-ras mutations in mouse lung tumors of extreme age: independent of paternal preconceptional exposure to chromium(III) but significantly more frequent in carcinomas than adenomas.
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K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.
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K-ras mutations in nonmucinous ovarian epithelial tumors: a molecular analysis and clinicopathologic study of 144 patients.
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K-RAS mutations in ovarian and extraovarian lesions of serous tumors of borderline malignancy.
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K-ras mutations in sera of patients with colorectal neoplasias and long-standing inflammatory bowel disease.
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K-ras mutations in sinonasal adenocarcinomas in patients occupationally exposed to wood or leather dust.
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K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
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K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
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K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients with left-sided colorectal carcinoma.
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K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.
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K-ras oncogene mutations in neoplasias of kidney transplanted patients: preliminary results with a new technique.
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K-ras oncogene mutations in osteoclast-like giant cell tumors of the pancreas and liver: genetic evidence to support origin from the duct epithelium.
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K-ras oncogene mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
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K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment.
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K-ras point mutation in the nerve plexuses around the superior mesenteric artery in resectable adenocarcinoma of the pancreatic head: distribution pattern and related factors.
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K-ras point mutation is associated with enhancement by deoxycholic acid of colon carcinogenesis induced by azoxymethane, but not with its attenuation by all-trans-retinoic acid.
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K-RAS point mutation, and amplification of C-MYC and C-ERBB2 in colon adenocarcinoma.
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K-ras point mutations in endometrial carcinoma: effect on outcome is dependent on age of patient.
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K-ras point mutations in human colorectal carcinomas: relation to aneuploidy and metastasis.
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K-ras point mutations in spontaneously occurring endometrial adenocarcinomas in the Donryu rat.
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K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
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K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
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K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
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K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
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K-ras status does not predict successful hepatic resection of colorectal cancer metastasis.
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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.
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K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology.
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K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.
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K-Ras, H-Ras, N-Ras and B-Raf mutation and expression analysis in Wilms tumors: association with tumor growth.
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K-Ras-Activated Cells Can Develop into Lung Tumors When Runx3-Mediated Tumor Suppressor Pathways Are Abrogated.
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K-rasG12V mediated lung tumor models identified three new quantitative trait loci modifying events post-K-ras mutation.
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Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein.
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Keratin 20 is a specific marker of submicroscopic lymph node metastases in colorectal cancer: validation by K-RAS mutations.
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Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis.
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Kinetics of O(6)()-Methyl-2'-deoxyguanosine Repair by O(6)()-Alkylguanine DNA Alkyltransferase within K-ras Gene-Derived DNA Sequences.
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KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.
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KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.
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Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation.
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Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC-7901 cells.
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Knockdown of Rab21 inhibits proliferation and induces apoptosis in human glioma cells.
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KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants.
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KRAS insertion mutations are oncogenic and exhibit distinct functional properties.
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KRAS mutant NSCLC, a new opportunity for the synthetic lethality therapeutic approach.
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KRAS Mutation Testing of Colorectal Cancer for Anti-EGFR Therapy: Dogmas versus Evidence.
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Krüppel-like factor 8 promotes tumorigenic mammary stem cell induction by targeting miR-146a.
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Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
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Lack of p53 and ras mutations in Helicobacter hepaticus-induced liver tumors in A/JCr mice.
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Lack of prognostic significance of p53 and K-ras mutations in primary resected non-small-cell lung cancer on E4592: a Laboratory Ancillary Study on an Eastern Cooperative Oncology Group Prospective Randomized Trial of Postoperative Adjuvant Therapy.
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Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.
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LATS2 tumour specific mutations and down-regulation of the gene in non-small cell carcinoma.
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Lentivirus-mediated carboxyl-terminal modulator protein gene transfection via aerosol in lungs of K-ras null mice.
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Let-7 microRNA transfer in pancreatic cancer-derived cells inhibits in vitro cell proliferation but fails to alter tumor progression.
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Let-7c functions as a metastasis suppressor by targeting MMP11 and PBX3 in colorectal cancer.
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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.
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Levels and membrane localization of the c-K-ras p21 protein in lungs of mice of different genetic strains and effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Aroclor 1254.
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Levels of 4-aminobiphenyl-induced somatic H-ras mutation in mouse liver DNA correlate with potential for liver tumor development.
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Life-span inhalation exposure to mainstream cigarette smoke induces lung cancer in B6C3F1 mice through genetic and epigenetic pathways.
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Lifetime history of alcohol consumption and K-ras mutations in pancreatic ductal adenocarcinoma.
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Lignan precursors from flaxseed or rye bran do not protect against the development of intestinal neoplasia in ApcMin mice.
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Limonene chemoprevention of mammary carcinoma induction following direct in situ transfer of v-Ha-ras.
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Lin28 promotes transformation and is associated with advanced human malignancies.
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Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.
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lincRNA-RoR and miR-145 regulate invasion in triple-negative breast cancer via targeting ARF6.
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Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity.
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Liver tumors induced in B6C3F1 mice by 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene contain K-ras protooncogene mutations.
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lncRNA OSER1-AS1 acts as a ceRNA to promote tumorigenesis in hepatocellular carcinoma by regulating miR-372-3p/Rab23 axis.
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lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer.
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Localization of IQGAP1 is inversely correlated with intercellular adhesion mediated by e-cadherin in gastric cancers.
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Localized Rho GTPase activation regulates RNA dynamics and compartmentalization in tumor cell protrusions.
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Long non-coding RNA NEAT1 promotes tumor development and metastasis through targeting RAB9A in malignant melanoma.
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Long Noncoding RNA LUADT1 Is Upregulated in Melanoma and May Sponge miR-28-5p to Upregulate RAP1B.
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Long-term follow-up of patients with a clinically benign extrahepatic biliary stenosis and K-ras mutation in endobiliary brush cytology.
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Loss of a reporter gene for green fluorescent protein during tumor progression suggests the recruitment of host cells in rats with experimentally induced colon cancer.
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Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo.
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Loss of Apc and the entire chromosome 18 but absence of mutations at the Ras and Tp53 genes in intestinal tumors from Apc1638N, a mouse model for Apc-driven carcinogenesis.
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Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon.
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Loss of Fhit expression in non-small-cell lung cancer: correlation with molecular genetic abnormalities and clinicopathological features.
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Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.
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Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
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Loss of heterozygosity and microsatellite instability of the h-ras gene in cancer of the head and neck.
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Loss of heterozygosity at the human RAP1A/Krev-1 locus is a rare event in colorectal tumors.
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Loss of heterozygosity on the short arm of chromosome 3 in carcinoma of the uterine cervix.
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Loss of p53 cooperates with K-ras activation to induce glioma formation in a region-independent manner.
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Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy.
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Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state.
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Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice.
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Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
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Low frequency of H-ras activation in naturally occurring hepatocellular tumors of C3H/HeNCr mice.
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Low frequency of H-ras mutations in hepatocellular adenomas and carcinomas and in hepatoblastomas from B6C3F1 mice exposed to oxazepam in the diet.
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Low frequency of p53 and k-ras codon 12 mutations in non-small cell lung carcinoma (NSCLC) tumors and surgical margins.
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Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
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Low mutational rate of K-ras codon 12 in singular bronchoscopy specimens in suspected lung cancer.
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Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.
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Low-dose metronomic cyclophosphamide treatment mediates ischemia-dependent K-ras mutation in colorectal carcinoma xenografts.
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Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer.
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Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas.
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LRRC4 inhibits glioma cell growth and invasion through a miR-185-dependent pathway.
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Lung cancer and past occupational exposure to asbestos. Role of p53 and K-ras mutations.
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Lung tumor induced by long-term inhalation or intratracheal instillation of diesel exhaust particles.
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Lung-targeted expression of the c-Raf-1 kinase in transgenic mice exposes a novel oncogenic character of the wild-type protein.
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Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation.
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M-Ras induces Ral and JNK activation to regulate MEK/ERK-independent gene expression in MCF-7 breast cancer cells.
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Machine Learning Helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer.
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Machineries regulating the activity of the small GTPase Arf6 in cancer cells are potential targets for developing innovative anti-cancer drugs.
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Macropinocytosis of the PDGF ?-receptor promotes fibroblast transformation by H-RasG12V.
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Maintenance BEZ235 Treatment Prolongs the Therapeutic Effect of the Combination of BEZ235 and Radiotherapy for Colorectal Cancer.
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Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review).
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Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient.
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Malignant fibrous histiocytoma of the pancreas: a case report with genetic analysis.
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Malignant transformation of a mouse liver epithelial cell line by transfection of an activated c-H-ras gene with a point mutation at codon 12.
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Malignant transformation of an epithelial cell by v-Src via tv-a-mediated retroviral infection: a new cell model for studying carcinogenesis.
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Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice.
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MALT1 is required for EGFR-induced NF-?B activation and contributes to EGFR-driven lung cancer progression.
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Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
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Mammosomatotroph adenoma causing gigantism in an 8-year old boy: a possible pathogenetic mechanism.
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Map kinase activation correlates with K-ras mutation and loss of heterozygosity on chromosome 6 in alveolar bronchiolar carcinomas from B6C3F1 mice exposed to vanadium pentoxide for 2 years.
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MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival.
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Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm.
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Maspin controls mammary tumor cell migration through inhibiting Rac1 and Cdc42, but not the RhoA GTPase.
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Matrix metalloproteinase?2 regulates MDA?MB?231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1.
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MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells.
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Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
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Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
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Mechanism of H-ras oncogene activation in mouse squamous carcinoma induced by an alkylating agent.
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Medicinal Chemistry and Pharmacology Focused on Cannabidiol, a Major Component of the Fiber-Type Cannabis.
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MEK inhibition suppresses K-Ras wild-type cholangiocarcinoma in vitro and in vivo via inhibiting cell proliferation and modulating tumor microenvironment.
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MEK1/2 inhibitors AS703026 and AZD6244 may be potential therapies for KRAS mutated colorectal cancer that is resistant to EGFR monoclonal antibody therapy.
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Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas.
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Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET.
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Melanoma-released exosomes directly activate the mitochondrial apoptotic pathway of CD4+ T cells through their microRNA cargo.
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Melphalan inhibits adenoma development through modulating the expression of K-ras-specific markers in K-ras Tg mice.
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Melting temperature analysis as quantitative method for detection of point mutations.
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Memory T cells of a patient with follicular thyroid carcinoma recognize peptides derived from mutated p21 ras (Gln-->Leu61).
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Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS
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Metabolic remodeling of the tumor microenvironment: Migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth.
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Metastatic MHC class I-negative mouse cells derived by transformation with human papillomavirus type 16.
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Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
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Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
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Methylation associated inactivation of RASSF1A and its synergistic effect with activated K-Ras in nasopharyngeal carcinoma.
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Methylation of estrogen receptor 1 in colorectal adenomas is not age-dependent, but is correlated with K-ras mutation.
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Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.
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Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.
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Methylation patterns and K-ras mutations in tumor and paired serum of resected non-small-cell lung cancer patients.
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METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
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Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity.
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Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT.
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Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
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Microdissection and polymerase chain reaction amplification of genomic DNA from histological tissue sections.
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MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention.
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MicroRNA Regulation of the Small Rho GTPase Regulators-Complexities and Opportunities in Targeting Cancer Metastasis.
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MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
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MicroRNA-143 shows tumor suppressive effects through inhibition of oncogenic K-Ras in pituitary tumor.
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MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer.
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microRNA-148a-3p inhibited the proliferation and epithelial-mesenchymal transition progression of non-small-cell lung cancer via modulating Ras/MAPK/Erk signaling.
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MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23.
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MicroRNA-188-5p promotes apoptosis and inhibits cell proliferation of breast cancer cells via the MAPK signaling pathway by targeting Rap2c.
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microRNA-195-Cdc42 axis acts as a prognostic factor of esophageal squamous cell carcinoma.
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microRNA-214 functions as a tumor suppressor in human colon cancer via the suppression of ADP-ribosylation factor-like protein 2.
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MicroRNA-29a functions as a potential tumor suppressor through directly targeting CDC42 in non-small cell lung cancer.
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MicroRNA-382-5p aggravates breast cancer progression by regulating the RERG/Ras/ERK signaling axis.
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MicroRNA-622 functions as a tumor suppressor by targeting K-Ras and enhancing the anticarcinogenic effect of resveratrol.
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MicroRNA?195 suppresses cell proliferation, migration and invasion in epithelial ovarian carcinoma via inhibition of the CDC42/CCND1 pathway.
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MicroRNA?342?3p suppresses proliferation and invasion of nasopharyngeal carcinoma cells by directly targeting Cdc42.
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MicroRNAs targeting mutant K-ras by electrotransfer inhibit human colorectal adenocarcinoma cell growth in vitro and in vivo.
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Microsatellite alterations and K-ras, TGFbetaRII, IGFRII and bax mutations in sporadic cancers of the gastrointestinal tract.
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Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
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Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
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Microsatellite instability and K-ras mutations in patients with ulcerative colitis.
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Microvessel density, cyclo-oxygenase 2 expression, K-ras mutation and p53 overexpression in colonic cancer.
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Minireview: Role of genetic changes of faciogenital dysplasia protein 1 in human disease.
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miR-1, regulated by LMP1, suppresses tumour growth and metastasis by targeting K-ras in nasopharyngeal carcinoma.
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miR-107 functions as a tumor suppressor in human esophageal squamous cell carcinoma and targets Cdc42.
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miR-137 targets Cdc42 expression, induces cell cycle G1 arrest and inhibits invasion in colorectal cancer cells.
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miR-143 inhibits the metastasis of pancreatic cancer and an associated signaling pathway.
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miR-144 suppresses cell proliferation and migration in colorectal cancer by targeting NRAS.
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miR-145-5p Acts as a Novel Tumor Suppressor in Hepatocellular Carcinoma Through Targeting RAB18.
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miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
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MiR-181d functions as a potential tumor suppressor in oral squamous cell carcinoma by targeting K-ras.
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miR-185 targets RhoA and Cdc42 expression and inhibits the proliferation potential of human colorectal cells.
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MiR-185-5p targets RAB35 gene to regulate tumor cell-derived exosomes-mediated proliferation, migration and invasion of non-small cell lung cancer cells.
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miR-18a inhibits CDC42 and plays a tumour suppressor role in colorectal cancer cells.
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MiR-199a Inhibits Tumor Growth and Attenuates Chemoresistance by Targeting K-RAS via AKT and ERK Signalings.
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MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma [Retraction].
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MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma.
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miR-211 regulates the expression of RRM2 in tumoral metastasis and recurrence in colorectal cancer patients with a k-ras gene mutation.
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miR-28-5p acts as a tumor suppressor in renal cell carcinoma for multiple antitumor effects by targeting RAP1B.
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miR-29a/b/c function as invasion suppressors for gliomas by targeting CDC42 and predict the prognosis of patients.
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miR-330 regulates the proliferation of colorectal cancer cells by targeting Cdc42.
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miR-384 suppressed renal cell carcinoma cell proliferation and migration through targeting RAB23.
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miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
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MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18.
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MiR-501-3p functions as a tumor suppressor in non-small cell lung cancer by downregulating RAP1A.
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miR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma.
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miR-597-3p inhibits invasion and migration of thyroid carcinoma SW579 cell by targeting RAB23.
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miR-769-5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cells.
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miR?367?3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.
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miRNA-143 replacement therapy harnesses the proliferation and migration of colorectal cancer cells in vitro.
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miRNA-34 prevents cancer initiation and progression in a therapeutically-resistant K-ras and p53-induced mouse model of lung adenocarcinoma.
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miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis.
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Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma.
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Mixtures of Uncaria and Tabebuia extracts are potentially chemopreventive in CBA/Ca mice: a long-term experiment.
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MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway.
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Modified mismatch polymerase chain reaction-restriction fragment length polymorphism detected mutations in codon 12 and 13 of exon 2 of K-
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Modulation of ABCG2 surface expression by Rab5 and Rab21 to overcome multidrug resistance in cancer cells.
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Modulation of apoptosis, tumorigenesity and metastatic potential with antisense H-ras oligodeoxynucleotides in a high metastatic tumor model of hepatoma: LCI-D20.
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Modulation of azoxymethane-induced mutational activation of ras protooncogenes by chemopreventive agents in colon carcinogenesis.
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Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
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Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy.
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Modulation of tumor induction and progression of oncogenic K-ras-positive tumors in the presence of TGF- b1 haploinsufficiency.
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Molecular alterations associated with improved survival in pancreatic cancer patients treated with radiation or chemotherapy.
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Molecular alterations in spontaneous sputum of cancer-free heavy smokers: results from a large screening program.
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Molecular analyses of liver tumors in c-myc transgenic mice and c-myc and TGF-alpha double transgenic mice.
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Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasms.
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Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma.
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Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
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Molecular and genetic events in schistosomiasis-associated human bladder cancer: role of oncogenes and tumor suppressor genes.
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Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
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Molecular and Pharmacological Characterization of the Interaction between Human Geranylgeranyltransferase Type I and Ras-Related Protein Rap1B.
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Molecular aspects of chemical carcinogenesis: the roles of oncogenes and tumour suppressor genes.
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Molecular assessment of depth of myometrial invasion in stage I endometrial cancer: a model based on K-ras mutation analysis.
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Molecular assessment of lymph nodes in patients with resected stage I non-small cell lung cancer: preliminary results of a prospective study.
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Molecular Associations and Clinical Significance of RAPs in Hepatocellular Carcinoma.
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Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring.
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Molecular beacon imaging of tumor marker gene expression in pancreatic cancer cells.
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Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective.
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Molecular biology studies on mesothelioma tumor samples: preliminary data on H-ras, p21, and SV40.
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Molecular changes in second primary lung and breast cancers after therapy for Hodgkin's disease.
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Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40.
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Molecular characteristics of poorly differentiated adenocarcinoma and signet-ring-cell carcinoma of colorectum.
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Molecular cloning of Copenhagen rat Krev-1 and rap1B cDNAs and study of their association with mammary tumor resistance in the Copenhagen rat.
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Molecular cloning of rat Krev-1 cDNA and analysis of the mRNA levels in normal and NMU-induced mammary carcinomas.
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Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
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Molecular detection of codon 12 K-RAS mutations in circulating DNA from serum of colorectal cancer patients.
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Molecular detection of genetic alterations in the serum of colorectal cancer patients.
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Molecular detection of neoplastic cells in lymph nodes of metastatic colorectal cancer patients predicts recurrence.
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Molecular Diagnosis of Response to Neoadjuvant Chemoradiation Therapy in Patients with Locally Advanced Rectal Cancer.
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Molecular diagnostic testing as an adjunct to morphologic evaluation of pancreatic ductal system brushings: potential augmentation for diagnostic sensitivity.
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Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia.
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Molecular epizootiology of genotoxic events in marine fish: linking contaminant exposure, DNA damage, and tissue-level alterations.
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Molecular evidence of field cancerization in a patient with 7 tumors of the aerodigestive tract.
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Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors.
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Molecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area.
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Molecular genetic analysis of appendiceal mucinous adenomas in identical twins, including one with pseudomyxoma peritonei.
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Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero.
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Molecular genetic analysis of placental site trophoblastic tumors and epithelioid trophoblastic tumors confirms their trophoblastic origin.
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Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
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Molecular genetic characterization of BRCA1- and BRCA2-linked hereditary ovarian cancers.
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Molecular genetic evidence supporting the clonality and appendiceal origin of Pseudomyxoma peritonei in women.
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Molecular genetic tumor markers in the early diagnosis and screening of non-small-cell lung cancer.
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Molecular lesions in colorectal cancer: impact on prognosis? Original data and review of the literature.
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Molecular markers as intermediate end-points in chemoprevention of colon-cancer - modulation of ras activation by sulindac and phenylhexylisothiocyanate during colon carcinogenesis.
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Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.
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Molecular mechanisms and biological plausibility underlying the malignant transformation of endometriosis: a critical analysis.
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Molecular mechanisms of invasion and metastasis during mouse skin tumour progression.
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Molecular mechanisms of platelet activation and aggregation induced by breast cancer cells.
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Molecular pathogenesis of intraductal papillary mucinous neoplasms of the pancreas.
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Molecular pathogenesis of pancreatic adenocarcinoma: Potential clinical implications.
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Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: clinical implications.
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Molecular pathology of hemangiopericytomas accompanied by severe hypoglycemia: oncogenes, tumor-suppressor genes and the insulin-like growth factor family.
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Molecular pathways: targeting p21-activated kinase 1 signaling in cancer--opportunities, challenges, and limitations.
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Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers.
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Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.
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Molecular profiles of EGFR, K-ras, c-met, and FGFR in pulmonary pleomorphic carcinoma, a rare lung malignancy.
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Molecular Profiling of Synchronous and Metachronous Cancers of the Pancreas Reveal Molecular Mimicry Between Samples from the Same Patient.
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Molecular staging of colorectal cancer: K-ras mutation analysis of lymph nodes upstages Dukes B patients.
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Monitoring of gene expression by functional proteomics: response of human lung fibroblast cells to stimulation by endothelin-1.
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Morelloflavone, a biflavonoid, inhibits tumor angiogenesis by targeting rho GTPases and extracellular signal-regulated kinase signaling pathways.
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Morphologic change and elevation of cortisol secretion in cultured human normal adrenocortical cells caused by mutant p21K-ras protein.
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Morphological and molecular characterization of an undifferentiated soft tissue sarcoma cell line and derivative clones.
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Morphological and molecular heterogeneity in colorectal neoplasms with K-RAS mutation. A report of two cases.
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Morphological and molecular heterogeneity within nonmicrosatellite instability-high colorectal cancer.
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Mosaic analysis and tumor induction in zebrafish by microsatellite instability-mediated stochastic gene expression.
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Mouse embryo fibroblasts transformed by activated ras or dominant-negative p53 express cross-reactive tumor rejection antigens.
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Mouse mammary tumor virus/v-Ha-ras transgene-induced mammary tumors exhibit strain-specific allelic loss on mouse chromosome 4.
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Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene.
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Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.
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Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.
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MSX2 in pancreatic tumor development and its clinical application for the diagnosis of pancreatic ductal adenocarcinoma.
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Mucinous cystic carcinoma of the pancreas: a unique cell line and xenograft model of a preinvasive lesion.
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Mucosal HPV E6/E7 Peptide Vaccination in Combination with Immune Checkpoint Modulation Induces Regression of HPV+ Oral Cancers.
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Multicenter analysis of risk factors for anastomotic leakage after middle and low rectal cancer resection without diverting stoma: a retrospective study of 319 consecutive patients.
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Multiple hyperplastic polyps in the stomach: evidence for clonality and neoplastic potential.
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Multiple K-ras codon 12 mutations in cholangiocarcinomas demonstrated with a sensitive polymerase chain reaction technique.
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Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais.
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Multiple synchronous primaries of the gastrointestinal tract: a molecular case report.
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Multiplicity of abnormal promoter methylation in lung adenocarcinomas from smokers and never smokers.
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Multistage carcinogenesis in murine thymocytes: involvement of oncogenes, chromosomal imbalances and T cell growth factor receptor.
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Mutagenesis in monkey cells of a vector containing a single d(GPG) cis-diamminedichloroplatinum(II) adduct placed on codon 13 of the human H-ras proto-oncogene.
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Mutagenesis of the K-ras protooncogene in mouse lung tumors induced by N-ethyl-N-nitrosourea or N-nitrosodiethylamine.
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Mutant DNA in plasma of lung cancer patients: potential for monitoring response to therapy.
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Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.
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Mutant K-ras enhances apoptosis in embryonic stem cells in combination with DNA damage and is associated with increased levels of p19(ARF).
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Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis.
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Mutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability.
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Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
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Mutated D4-guanine diphosphate-dissociation inhibitor is found in human leukemic cells and promotes leukemic cell invasion.
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Mutated K-ras gene analysis in a randomized trial of preoperative chemotherapy plus surgery versus surgery in stage IIIA non-small cell lung cancer.
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Mutated ras p21 as a target for cancer therapy in mouse transitional cell carcinoma.
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Mutation analysis of K-ras oncogenes in gastroenterologic cancers by the amplified created restriction sites method.
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Mutation analysis of K-ras-2 in liver angiosarcoma and adjacent nonneoplastic liver tissue from patients occupationally exposed to vinyl chloride.
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Mutation analysis of p53, K-ras, and BRAF genes in colorectal cancer progression.
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Mutation detection in K-ras, BRCA1, BRCA2, and p53 using PCR/LDR and a universal DNA microarray.
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Mutation in the K-ras gene at codon 12 does not correlate with disease progression in colorectal carcinoma patients treated with 5-FU/folinic acid biomodulated chemotherapy.
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Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.
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Mutation of K-ras protooncogene in human ovarian epithelial tumors of borderline malignancy.
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Mutation of K-ras protooncogene is associated with histological subtypes in human mucinous ovarian tumors.
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Mutation of p53 and K-ras, and loss of heterozygosity of APC in intrahepatic cholangiocarcinoma.
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Mutation of the nm23 gene, loss of heterozygosity at the nm23 locus and K-ras mutation in ovarian carcinoma: correlation with tumour progression and nm23 gene expression.
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Mutation of the transforming growth factor-beta type II receptor gene in right-sided colorectal cancer: relationship to clinicopathological features and genetic alterations.
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Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.
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Mutation Status of K-ras, p53 and Allelic Losses at 9p and 18q Are Not Prognostic Markers in Patients with Pancreatic Cancer.
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Mutational activation of H-ras and K-ras genes is absent in N-nitroso-N-methylurea-induced liver tumors in rats.
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Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study.
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Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung.
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Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers.
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Mutational analysis of BRAF in gallbladder carcinomas in association with K-ras and p53 mutations and microsatellite instability.
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Mutational analysis of K-ras and Ras protein expression in larynx squamous cell carcinoma.
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Mutational analysis of K-ras segregates ovarian serous carcinomas into two types: invasive MPSC (low-grade tumor) and conventional serous carcinoma (high-grade tumor).
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Mutational analysis of Ras hotspots in patients with urothelial carcinoma of the bladder.
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Mutational analysis of the BRAF gene in colorectal mucinous carcinoma in association with histological configuration.
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Mutational analysis of the H-ras oncogene in spontaneous C57BL/6 x C3H/He mouse liver tumors and tumors induced with genotoxic and nongenotoxic hepatocarcinogens.
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Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features.
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Mutational analysis of the p53 and K-ras genes and allelotype study of the Rb-1 gene for investigating the pathogenesis of combined hapatocellular-cholangiocellular carcinomas.
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Mutational and nonmutational activation of p21ras in rat colonic azoxymethane-induced tumors: effects on mitogen-activated protein kinase, cyclooxygenase-2, and cyclin D1.
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Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach.
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Mutational spectrum of K-ras oncogene among Indian patients with gallbladder cancer.
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Mutations associated with in vivo aflatoxin B1-induced carcinogenesis need not be present in the in vitro transformations by this toxin.
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Mutations in an alternatively spliced exon of h-ras are not associated with loss of heterozygosity on chromosome 11p15.5 in ovarian tumorigenesis.
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Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
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Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer.
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Mutations in codons 12 and 13 of K-ras exon 2 in colorectal tumors of Saudi Arabian patients: frequency, clincopathological associations, and clinical outcomes.
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Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer.
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Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands.
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Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma.
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Mutations in the ras proto-oncogene: clues to etiology and molecular pathogenesis of mouse liver tumors.
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Mutations of K-ras oncogene and absence of H-ras mutations in squamous cell carcinomas of the lung.
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Mutations of p53 and K-ras genes as prognostic factors for non-small cell lung cancer.
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Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.
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Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.
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Mutations of the K-ras and p53 genes in gastric adenocarcinomas from a high-incidence region around Florence, Italy.
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Mutations of the p53 gene and p53 protein overexpression are associated with sarcomatoid transformation in renal cell carcinomas.
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Mutations, expression and genomic instability of the H-ras proto-oncogene in squamous cell carcinomas of the head and neck.
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Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.
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MYC-nick promotes cell migration by inducing fascin expression and Cdc42 activation.
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Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC.
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N-nitrosocimetidine as an initiator of murine skin tumors with associated H-ras oncogene activation.
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NAD(P)H:quinone oxidoreductase-dependent risk for colorectal cancer and its association with the presence of K-ras mutations in tumors.
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Nanobody-Based Quantification of GTP-Bound RHO Conformation Reveals RHOA and RHOC Activation Independent from Their Total Expression in Breast Cancer.
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Nanomechanical Characteristics of Cervical Cancer and Cervical Intraepithelial Neoplasia Revealed by Atomic Force Microscopy.
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Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer.
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Natural history of colorectal nonpolypoid adenomas: a prospective colonoscopic study and relation with cell kinetics and K-ras mutations.
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Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice.
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NDRG1 regulates Filopodia-induced Colorectal Cancer invasiveness via modulating CDC42 activity.
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Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan.
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Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer.
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Neoplastic reprogramming of patient-derived adipose stem cells by prostate cancer cell-associated exosomes.
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Neoplastic reversion accomplished by high efficiency adenoviral-mediated delivery of an anti-ras ribozyme.
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Neoplastic transformation of human keratinocytes by polybrene-induced DNA-mediated transfer of an activated oncogene.
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Neoplastic transformation of human osteoblast cells to the tumorigenic phenotype by heavy metal-tungsten alloy particles: induction of genotoxic effects.
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Neoplastic transformation of rat colon epithelial cells by expression of activated human K-ras.
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Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells.
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Nestin predicts a favorable prognosis in early ampullary adenocarcinoma and functions as a promoter of metastasis in advanced cancer.
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Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
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Neurofibromin 1 Impairs Natural Killer T-Cell-Dependent Antitumor Immunity against a T-Cell Lymphoma.
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Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.
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Neurofibromin is required for barrel formation in the mouse somatosensory cortex.
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Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation.
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New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
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New molecular approaches to lung cancer: biological and clinical implications of P53, P16 and K-RAS studies.
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New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
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NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells.
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Nicotine does not enhance tumorigenesis in mutant K-ras-driven mouse models of lung cancer.
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Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42.
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NIH3T3 transfectant containing human K-ras oncogene shows enhanced metastatic activity after in vivo tumor growth or co-culture with fibroblasts.
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Nitrosamine-induced cancer: selective repair and conformational differences between O6-methylguanine residues in different positions in and around codon 12 of rat H-ras.
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NKX6.3 Is a Transcription Factor for Wnt/?-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression.
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NMR 1H,13C, 15N backbone and 13C side chain resonance assignment of the G12C mutant of human K-Ras bound to GDP.
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NMR 1H,13C, 15N resonance assignment of the G12C mutant of human K-Ras bound to GppNHp.
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No evidence for point mutations in codons 12, 13, and 61 of the ras gene in a high-incidence area for esophageal and gastric cancers.
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No major difference in K-ras and p53 abnormalities in sporadic and hereditary nonpolyposis colorectal adenomas.
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No-touch isolation technique reduces intraoperative shedding of tumor cells into the portal vein during resection of colorectal cancer.
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Non-radioactive detection of K-ras mutations by nested allele specific PCR and oligonucleotide hybridization.
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Non-Small-Cell Lung Cancer Signaling Pathways, Metabolism, and PD-1/PD-L1 Antibodies.
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Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase.
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Noncorrelative c-myc and ras oncogene expression in squamous cell carcinoma cells with tumorigenic potential.
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Nonfunctioning islet cell carcinoma of the pancreas with high serum CEA & CA19-9, K-ras codon 12 mutation, and microsatellite instability.
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Noninvasive image texture analysis differentiates K-ras mutation from pan-wildtype NSCLC and is prognostic.
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Not infrequent K-ras mutations in depressed-type early colorectal carcinomas larger than 10 mm.
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Notch1 destabilizes the adherens junction complex through upregulation of the Snail family of E-cadherin repressors in non-small cell lung cancer.
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Novel anti-carcinogenic activity of an organosulfide from garlic: inhibition of H-RAS oncogene transformed tumor growth in vivo by diallyl disulfide is associated with inhibition of p21H-ras processing.
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Novel involvement of RhebL1 in sphingosylphosphorylcholine-induced keratin phosphorylation and reorganization: Binding to and activation of AKT1.
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Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.
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Novel Suppressive Effects of Ketotifen on Migration and Invasion of MDA-MB-231 and HT-1080 Cancer Cells.
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Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells.
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Novel targeting approaches and signaling pathways of colorectal cancer: An insight.
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Novel ternary vanadium-betaine-peroxido species suppresses H-ras and matrix metalloproteinase-2 expression by increasing reactive oxygen species-mediated apoptosis in cancer cells.
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Novel transplatinum(II) complexes with [N2O2] donor sets. Cellular pharmacology and apoptosis induction in Pam 212-ras cells.
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Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
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NTP Toxicology and Carcinogenesis Studies of Oxazepam (CAS No. 604-75-1) in Swiss-Webster and B6C3F1 Mice (Feed Studies).
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Nuclear factor-kappaB (NF-kappaB) is frequently expressed in lung cancer and preneoplastic lesions.
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Nuclear-targeted deleted in liver cancer 1 (DLC1) is less efficient in exerting its tumor suppressive activity both in vitro and in vivo.
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Nucleotide-Specific Autoinhibition of Full-Length K-Ras4B Identified by Extensive Conformational Sampling.
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O(6)-methylguanine methyltransferase in colorectal cancers: detection of mutations, loss of expression, and weak association with G:C>A:T transitions.
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O(6)-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer.
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O-GlcNAcylation on Rab3A attenuates its effects on mitochondrial oxidative phosphorylation and metastasis in hepatocellular carcinoma.
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O6-methylguanine-DNA methyltransferase promoter hypermethylation in colorectal carcinogenesis.
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Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K-ras activation in human exocrine pancreatic cancer.
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Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer.
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Occurrence of H-ras codon 61 CAA to AAA mutation during mouse liver tumor progression.
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Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.
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Oncogene involvement in tumor regression: H-ras activation in the rabbit keratoacanthoma model.
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Oncogene mediated repression of glucocorticoid hormone response elements and glucocorticoid receptor levels.
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Oncogene Ras/Phosphatidylinositol 3-kinase (PI3K) signaling targets histone H3 acetylation at lysine K56.
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Oncogene-dependent survival of highly transformed cancer cells under conditions of extreme centrifugal force - implications for studies on extracellular vesicles.
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Oncogenic and wild-type Ras play divergent roles in the regulation of mitogen-activated protein kinase signaling.
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Oncogenic effects of RAB27B through exosome independent function in renal cell carcinoma including sunitinib-resistant.
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Oncogenic events regulate tissue factor expression in colorectal cancer cells: implications for tumor progression and angiogenesis.
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Oncogenic K-ras activates p38 to maintain colorectal cancer cell proliferation during MEK inhibition.
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Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.
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Oncogenic K-Ras decouples glucose and glutamine metabolism to support cancer cell growth.
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Oncogenic K-Ras down-regulates Rac1 and RhoA activity and enhances migration and invasion of pancreatic carcinoma cells through activation of p38.
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Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells.
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Oncogenic K-Ras segregates at spatially distinct plasma membrane signaling platforms according to its phosphorylation status.
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Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells.
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Oncogenic K-Ras Turns Death Receptors Into Metastasis-Promoting Receptors in Human and Mouse Colorectal Cancer Cells.
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Oncogenic levels of mitogen-activated protein kinase (MAPK) signaling of the dinucleotide KRAS2 mutations G12F and GG12-13VC.
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Oncogenic pathway of sporadic colorectal cancer with novel germline missense mutations in the hMSH2 gene.
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Oncogenic Pathways and Loss of the Rab11 GTPase Synergize To Alter Metabolism in Drosophila.
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Oncogenic Ras mutant causes the hyperactivation of NF-?B via acceleration of its transcriptional activation.
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Oncogenic Ras promotes butyrate-induced apoptosis through inhibition of gelsolin expression.
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Oncogenic Ras triggers hyperproliferation and impairs polarized colonic morphogenesis by autocrine ErbB3 signaling.
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Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells.
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Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
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Oncogenic signaling is dominant to cell of origin and dictates astrocytic or oligodendroglial tumor development from oligodendrocyte precursor cells.
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Oncogenic Smad3 signaling induced by chronic inflammation is an early event in ulcerative colitis-associated carcinogenesis.
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Oncogenicity of DNA in vivo: tumor induction with expression plasmids for activated H-ras and c-myc.
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Opposing prognostic roles of nuclear and cytoplasmic RACGAP1 expression in colorectal cancer patients.
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Optimal preservation of p21 ras immunoreactivity and morphology in paraffin-embedded tissue.
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Optimization of a nonradioactive method for consistent and sensitive determination of activated K-ras protein.
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Oral benzo[a]pyrene-induced cancer: two distinct types in different target organs depend on the mouse Cyp1 genotype.
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Ornithine decarboxylase gene expression is aberrantly regulated via the cAMP signal transduction pathway in malignant H-ras transformed cell lines.
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Orthotopic transplantation model of human gastrointestinal cancer and detection of micrometastases.
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Orthotopic transplantation models of pancreatic adenocarcinoma derived from cell lines and primary tumors and displaying varying metastatic activity.
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Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
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Osteoclast-like giant cell tumor in mucinous cystadenocarcinoma of the pancreas: an immunohistochemical and molecular analysis.
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Osteoclast-like giant cell tumor of the pancreas with metastases to gallbladder and lymph nodes. A case report.
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Osteopontin, a transformation-associated cell adhesion phosphoprotein, is induced by 12-O-tetradecanoylphorbol 13-acetate in mouse epidermis.
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Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.
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Ovarian clear cell carcinomas: RHO GTPases may contribute to explain their singular biologic behavior.
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Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?
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Over-expression of Rap2a inhibits glioma migration and invasion by down-regulating p-AKT.
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Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding ras and activating ras signaling.
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Overexpressed let-7a inhibits glioma cell malignancy by directly targeting K-ras, independently of PTEN.
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Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis.
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Overexpression of Bcl-2 and mutations in p53 and K-ras in resected human non-small cell lung cancers.
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Overexpression of human H-ras transgene is responsible for tumors induced by chemical carcinogens in mice.
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Overexpression of P21-activated kinase 4 is associated with poor prognosis in non-small cell lung cancer and promotes migration and invasion.
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Overexpression of Rab1B and MMP9 predicts poor survival and good response to chemotherapy in patients with colorectal cancer.
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Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
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Overexpression of Rab40b Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway.
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Overexpression of Rac GTPase Activating Protein 1 Contributes to Proliferation of Cancer Cells by Reducing Hippo Signaling to Promote Cytokinesis.
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Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma.
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Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer.
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Overexpression of RhoV Promotes the Progression and EGFR-TKI Resistance of Lung Adenocarcinoma.
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Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes.
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Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers.
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Overexpression of the p53 tumor suppressor gene product in primary lung adenocarcinomas is associated with cigarette smoking.
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Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas.
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Overexpression of vascular endothelial growth factor isoforms drives oxygenation and growth but not progression to glioblastoma multiforme in a human model of gliomagenesis.
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p120-catenin is transcriptionally downregulated by FOXC2 in non-small cell lung cancer cells.
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P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.
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p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.
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p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
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p16(INK4A) Hypermethylation detected by fluorescent methylation-specific PCR in plasmas from non-small cell lung cancer.
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p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of phosphoinositide 3-kinase and Rac1 GTPase activities.
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P2X7 mRNA expression in non-small cell lung cancer: MicroRNA regulation and prognostic value.
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p38 kinase is a key signaling molecule for H-Ras-induced cell motility and invasive phenotype in human breast epithelial cells.
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p53 and H-ras mutations and microsatellite instability in renal pelvic carcinomas of NON / Shi mice treated with N-butyl-N-(4-hydroxybutyl)-nitrosamine: different genetic alteration from urinary bladder carcinoma.
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p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer.
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p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
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P53 and K-ras mutations are frequent events in microscopically negative surgical margins from patients with nonsmall cell lung carcinoma.
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p53 and K-ras mutations in lung tissues and sputum samples of individuals exposed to smoky coal emissions in Xuan Wei County, China.
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p53 and ras gene expression in human esophageal cancer and Barrett's epithelium: a prospective study.
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p53 gene mutation and p53 protein overexpression in a patient with simultaneous double cancer of the gallbladder and bile duct associated with pancreaticobiliary maljunction.
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P53 mutation but not p16/MTS1 mutation occurs in intraductal papillary mucinous tumors of the pancreas.
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p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer.
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P53 mutations in colorectal cancer from northern Iran: Relationships with site of tumor origin, microsatellite instability and K-ras mutations.
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p53 mutations in head and neck squamous cell carcinomas from Sudanese snuff (toombak) users.
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p53 mutations in lung tumors: relationship to putative susceptibility markers for cancer.
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p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
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p53 Overexpression and K-ras Codon 12 Mutations in Submucosal Invasive Colorectal Cancer.
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p53 overexpression and K-ras codon 12 mutations in submucosal invasive depressed-type colorectal cancer.
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p53 overexpression and K-ras gene mutations in primary sclerosing cholangitis-associated biliary tract cancer.
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p53 protein overexpression and K-ras codon 12 mutation in pancreatic ductal carcinoma: correlation with histologic factors.
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p53 tumor suppressor protein and H-RAS oncogene in maxillofacial tumors: immunohistochemical and genetic investigation, induction chemotherapy response and prognosis evaluation.
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p53, erbB-2 and K-ras gene alterations are rare in spontaneous and plutonium-239-induced canine lung neoplasia.
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p53, K-ras, c-kit and beta-catenin gene mutations in sinonasal NK/T-cell lymphoma in Korea and Japan.
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P53, N- and K-Ras, and beta-catenin gene mutations and prognostic factors in nasal NK/T-cell lymphoma from Hokkaido, Japan.
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P68 RNA helicase (DDX5) alters activity of cis- and trans-acting factors of the alternative splicing of H-Ras.
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p73 Isoforms affect VEGF, VEGF165b and PEDF expression in human colorectal tumors: VEGF165b downregulation as a marker of poor prognosis.
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P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin ?1/NF-?B pathway.
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Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene.
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Palladin promotes invasion of pancreatic cancer cells by enhancing invadopodia formation in cancer-associated fibroblasts.
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Pamidronate resistance and associated low ras levels in breast cancer cells: a role for combinatorial therapy.
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Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type K-ras and characteristic histopathology. Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+.
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Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
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Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors.
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Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study.
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Pancreatic mucinous cystic neoplasms with sarcomatous stroma: molecular evidence for monoclonal origin with subsequent divergence of the epithelial and sarcomatous components.
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Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2.
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Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
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Partial growth suppression of human prostate cancer cells by the Krev-1 suppressor gene.
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Partial response after treatment with Conversion chemotherapy: A case report of a patient with colon cancer and unresectable hepatic metastases.
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Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
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Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review).
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Pathologic and molecular features of screening low-dose computed tomography (LDCT)-detected lung cancer: a baseline and 2-year repeat study.
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Pathological functions of the small GTPase Arf6 in cancer progression: Tumor angiogenesis and metastasis.
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Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patients.
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Pattern of growth factor, proto-oncogene and carcinoembryonic antigen gene expression in human colorectal carcinoma cell lines.
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Patterns of K-ras mutation in colorectal carcinomas from Iran and Italy (a Gruppo Oncologico dell'Italia Meridionale study): influence of microsatellite instability status and country of origin.
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PCR bias toward the wild-type k-ras and p53 sequences: implications for PCR detection of mutations and cancer diagnosis.
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PCR-SSCP analysis of human adrenocortical adenomas: absence of K-ras gene mutations.
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PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D.
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Peptide modulators of Rac1/Tiam1 protein-protein interaction: An alternative approach for cardiovascular diseases.
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Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes.
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Peptide-specific activation of cytolytic CD4+ T lymphocytes against tumor cells bearing mutated epitopes of K-ras p21.
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Peroxiredoxin I is important for cancer-cell survival in Ras-induced hepatic tumorigenesis.
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Pharmacodynamics of DT-IgG, a dual-targeting antibody against VEGF-EGFR, in tumor xenografted mice.
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Pharmacokinetics of Rac inhibitor EHop-016 in mice by ultra-performance liquid chromatography tandem mass spectrometry.
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Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.
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Phase I and pharmacokinetic study of the farnesyltransferase inhibitor R115777 in combination with irinotecan in patients with advanced cancer.
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Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer.
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Phase I clinical trial of the farnesyltransferase inhibitor BMS-214662 given as a 1-hour intravenous infusion in patients with advanced solid tumors.
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Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort.
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Phase I Trial: Cirmtuzumab Inhibits ROR1 Signaling and Stemness Signatures in Patients with Chronic Lymphocytic Leukemia.
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Phenotype of bone metastases of non-small cell lung cancer: epidermal growth factor receptor expression and K-RAS mutational status.
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Phenotypic classification of gastric signet ring cell carcinoma and its relationship with K-ras mutation.
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Phenotypic reversion induced by anthracyclines in ras oncogene-expressed cells; structure-activity relationships.
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Phenotypic Screening Identifies Protein Synthesis Inhibitors as H-Ras-Nanocluster-Increasing Tumor Growth Inducers.
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Phorbol ester tumour promoter mediated altered expression and regulation of matrix metalloproteinase-2 in a H-ras transformed cell line capable of benign tumour formation.
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Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
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Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics.
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Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras.
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Phosphorylation of Rab37 by protein kinase C alpha inhibits the exocytosis function and metastasis suppression activity of Rab37.
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Phytohemagglutinin-L (PHA-L) lectin surface binding of N-linked beta 1-6 carbohydrate and its relationship to activated mutant ras in human pancreatic cancer cell lines.
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PI3-kinase ? promotes Rap1a-mediated activation of myeloid cell integrin ?4?1, leading to tumor inflammation and growth.
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PIK3CA mutations in the kinase domain (exon 20) of uterine endometrial adenocarcinomas are associated with adverse prognostic parameters.
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PKC Regulates a Farnesyl-Electrostatic Switch on K-Ras that Promotes its Association with Bcl-Xl on Mitochondria and Induces Apoptosis.
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PKC? regulates integrin ?V?3 expression and transformed growth of K-ras dependent lung cancer cells.
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Pleiotropic functions of Rho GTPase signaling: a Trojan horse or Achilles' heel for breast cancer treatment?
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Podoplanin promotes the invasion of oral squamous cell carcinoma in coordination with MT1-MMP and Rho GTPases.
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Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.
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Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years.
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Polyamine biosynthesis in relation to K-ras and p-53 mutations in colorectal carcinoma.
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Polyisoprenylated Cysteinyl Amide Inhibitors: A Novel Approach to Controlling Cancers with Hyperactive Growth Signaling.
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Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro.
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Polymer Nanovesicle-Mediated Delivery of MLN8237 Preferentially Inhibits Aurora Kinase A To Target RalA and Anchorage-Independent Growth in Breast Cancer Cells.
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Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
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Polymerase chain reaction/sequencing analysis of ras mutations in paraffin-embedded tissues as compared with 3T3 transfection and polymerase chain reaction/sequencing of frozen tumor deoxyribonucleic acids.
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Polymorphic variants of H-RAS protooncogene and their possible role in bladder cancer etiology.
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Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
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Polysialylated NCAM represses E-cadherin-mediated cell-cell adhesion in pancreatic tumor cells.
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Portal Venous Blood Circulation Supports Immunosuppressive Environment and Pancreatic Cancer Circulating Tumor Cell Activation.
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Positive immunohistochemical staining of p53 and cyclin D in advanced mouse skin tumors, but not in precancerous lesions produced by benzo[a]pyrene.
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Possible association of active gastritis, featuring accelerated cell turnover and p53 overexpression, with cancer development at anastomoses after gastrojejunostomy. Comparison with gastroduodenostomy.
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Possible carcinogenic effects of X-rays in a transgenerational study with CBA mice.
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Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer.
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Potentiation of lymphomagenesis by methylnitrosourea in mice transgenic for LMO1 is blocked by O6-alkylguanine DNA-alkyltransferase.
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Preclinical activity of EGFR and MEK1/2 inhibitors in the treatment of biliary tract carcinoma.
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Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
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Preclinical in vivo evaluation of efficacy, pharmacokinetics, and pharmacodynamics of a novel MEK1/2 kinase inhibitor RO5068760 in multiple tumor models.
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Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy.
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Prediction of breast cancer proteins involved in immunotherapy, metastasis, and RNA-binding using molecular descriptors and artificial neural networks.
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Predictive factors for outcome in a phase II study of gefitinib in second-line treatment of advanced esophageal cancer patients.
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Predictive factors for the efficacy of cetuximab plus chemotherapy as salvage therapy in metastatic gastric cancer patients.
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Predictive Molecular Tumour Testing: What Are the Obstacles between Bench and Bedside?
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Predictive signatures inform the effective repurposing of Decitabine to treat K-RAS-dependent Pancreatic Ductal Adenocarcinoma.
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Predictors of gefitinib outcomes in advanced non-small cell lung cancer (NSCLC): Study of a comprehensive panel of molecular markers.
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Preferential carcinogen-DNA adduct formation at codons 12 and 14 in the human K-ras gene and their possible mechanisms.
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Preferential DNA damage and poor repair determine ras gene mutational hotspot in human cancer.
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Preneoplastic potential of morphologically distinct transformed foci induced by 3-methylcholanthrene.
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Preresectional chemotherapy in stage IIIA non-small-cell lung cancer: a 7-year assessment of a randomized controlled trial.
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Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
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Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
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Prevalence of activating K-ras mutations in the evolutionary stages of neoplasia in intraductal papillary mucinous tumors of the pancreas.
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Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
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Prevalence of K-RAS mutations and CA125 tumor marker in patients with ovarian carcinoma.
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Prevalence of K-Ras mutations in hepatocellular carcinoma: A Turkish Oncology Group pilot study.
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Prevalence of p53 overexpression or mutations, but not k-ras mutations, in recurrent patients affected by colorectal-carcinoma.
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Prevention of K-Ras- and Pten-mediated intravaginal tumors by treatment with camptothecin-loaded PLGA nanoparticles.
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Prevention of orthotopic human lung cancer growth by intratracheal instillation of a retroviral antisense K-ras construct.
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Primary cancer of the small intestine and mutational analysis of the K-ras and p53 genes.
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Primary lung tumors in mice: an experimentally manipulable model of human adenocarcinoma.
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Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.
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Principles of K-Ras effector organization and the role of oncogenic K-Ras in cancer initiation through G1 cell cycle deregulation.
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Pro-apoptotic activity of oncogenic H-Ras for histone deacetylase inhibitor to induce apoptosis of human cancer HT29 cells.
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Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells.
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Problems in the diagnosis and treatment of a so-called mucin-producing tumor of the pancreas.
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Procathepsin L secretion, which triggers tumour progression, is regulated by Rab4a in human melanoma cells.
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Production of spindle cell carcinoma by transduction of H-Ras 61L into immortalized human mammary epithelial cells.
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Professor Frank McCormick: K-Ras proteins offer new opportunities for therapeutic intervention against human cancers.
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Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells.
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Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
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Progesterone and calcitriol reduce invasive potential of endometrial cancer cells by targeting ARF6, NEDD9 and MT1-MMP.
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Prognosis of human pancreatic adenocarcinoma: review of clinical and histopathological variables and possible uses of new molecular methods.
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Prognostic and Predictive Markers of Benefit from Adjuvant Chemotherapy in Early-Stage Non-small Cell Lung Cancer.
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Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer.
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Prognostic and predictive values of pERK1/2 and pAkt-1 expression in non-small cell lung cancer patients treated with adjuvant chemotherapy.
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Prognostic impact of K-RAS mutational status and primary tumor location in patients undergoing resection for colorectal cancer liver metastases: an update.
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Prognostic impact of K-RAS mutational status and primary tumour location in patients undergoing resection for colorectal cancer liver metastases: A METHEPAR analysis (multicentre study in Argentina).
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Prognostic implications of routine, immunohistochemical, and molecular staging in resectable pancreatic adenocarcinoma.
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Prognostic importance of tumor location and anti-EGFR therapy in patients with K-RAS wild type metastatic colorectal cancer.
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Prognostic role of K-ras in patients with progressive colon cancer who received treatment with Marimastat (BB2516).
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Prognostic role of Rab27A and Rab27B expression in patients with non-small cell lung carcinoma.
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Prognostic significance of DNA aneuploidy and p21 ras oncoprotein expression in colorectal cancer and their role in the determination of treatment modalities.
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Prognostic Significance of K- ras Codon 12 Mutation in Patients with Resected Gallbladder Cancer.
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Prognostic significance of K-ras and TP53 mutations in the role of adjuvant chemotherapy on survival in patients with Dukes C colon cancer.
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Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis.
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Prognostic significance of K-ras, p53, bcl-2, PCNA, CD34 in radically resected non-small cell lung cancers.
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Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer.
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Prognostic value of disseminated colorectal tumor cells in the liver: results of follow-up examinations.
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Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases.
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Prognostic value of k-ras 12 genotypes in patients with advanced nonsmall cell lung-cancer receiving Carboplatin with either intravenous or chronic oral dose Etoposide.
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Prognostic value of K-ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer.
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Prognostic value of K-ras mutations and allelic imbalance on chromosome 18q in patients with resected colorectal cancer.
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Prognostic value of Rab27B nuclear expression in gastrointestinal stromal tumors.
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Prognostic value of replication errors on chromosomes 2p and 3p in non-small-cell lung cancer.
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Progression of mouse skin carcinogenesis is associated with the orchestrated deregulation of miR-200 family members, miR-205 and their common targets.
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Progression of squamous carcinoma cells to spindle carcinomas of mouse skin is associated with an imbalance of H-ras alleles on chromosome 7.
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Proliferative heterogeneity of human renal cell carcinomas and prevalence of ras gene point mutations.
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Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human pancreatic cancer MIA PaCa-2 cells in vitro.
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Promoter hypermethylation of the DNA repair gene O(6)-methylguanine-DNA methyltransferase is associated with the presence of G:C to A:T transition mutations in p53 in human colorectal tumorigenesis.
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Promoter hypermethylation of the O6-methylguanine-DNA methyltransferase gene: more common in lung adenocarcinomas from never-smokers than smokers and associated with tumor progression.
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Promoter hypermethylation of tumor-related genes in the progression of colorectal neoplasia.
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Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers.
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Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.
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Prophylactic intervention of probiotics (L.acidophilus, L.rhamnosus GG) and celecoxib modulate Bax-mediated apoptosis in 1,2-dimethylhydrazine-induced experimental colon carcinogenesis.
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Protection against malignant progression of spontaneously developing liver tumors in transgenic mice expressing O(6)-methylguanine-DNA methyltransferase.
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Protein Kinase C {delta} Is a Downstream Effector of Oncogenic K-ras in Lung Tumors.
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Protein kinase C-alpha signals P115RhoGEF phosphorylation and RhoA activation in TNF-alpha-induced mouse brain microvascular endothelial cell barrier dysfunction.
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Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer.
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Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3? as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability.
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Proteomic and phosphoproteomic alterations in benign, premalignant and tumor human breast epithelial cells and xenograft lesions: biomarkers of progression.
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Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells.
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Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma.
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Proto-oncogene activation in liver tumors of hepatocarcinogenesis-resistant strains of mice.
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Proto-oncogene ras GTPase-linked induction of glutathione-S-transferase by growth factors in PC12 cells.
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PTEN dosage is essential for neurofibroma development and malignant transformation.
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Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer.
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PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients.
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PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations.
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Pulmonary tumors associated with the JC virus T-antigen in a transgenic mouse model.
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Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients.
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Qian Yang Yu Yin Granule-containing serum inhibits angiotensin II-induced proliferation, reactive oxygen species production, and inflammation in human mesangial cells via an NADPH oxidase 4-dependent pathway.
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Qualitative and quantitative changes in nuclear DNA and phenotypic gene expression in human malignant skin tumors during their progression.
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Quantitative analysis of K-ras gene mutation in pancreatic tissue obtained by endoscopic ultrasonography-guided fine needle aspiration: clinical utility for diagnosis of pancreatic tumor.
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Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer.
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Quantitative detection of mutant alleles of the K-ras gene with minor groove binder-conjugated fluorogenic DNA probes.
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Quantitative determination of K-ras mutations in pancreatic juice for diagnosis of pancreatic cancer using hybridization protection assay.
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Quaternized chitosan particles as ion exchange supports for label-free DNA detection using PNA probe and MALDI-TOF mass spectrometry.
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Quinacrine causes apoptosis in human cancer cell lines through caspase-mediated pathway and regulation of small-GTPase.
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R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
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Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.
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Rab11 collaborates E-cadherin to promote collective cell migration and indicates a poor prognosis in colorectal carcinoma.
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Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-?B) Signaling Pathway in Human Bladder Carcinoma.
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Rab11 regulates E-cadherin expression and induces cell transformation in colorectal carcinoma.
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Rab11-FIP1C is a critical negative regulator in ErbB2-mediated mammary tumor progression.
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Rab11a regulates MMP2 expression by activating the PI3K/AKT pathway in human hepatocellular carcinoma cells.
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Rab11FIP proteins link endocytic recycling vesicles for cytoskeletal transport and tethering.
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Rab14 is overexpressed in ovarian cancers and promotes ovarian cancer proliferation through Wnt pathway.
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Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.
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Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
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Rab23 contributes to the progression of colorectal cancer via protein kinase B and extracellular signal-regulated kinase signaling pathways.
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Rab23 is overexpressed in human astrocytoma and promotes cell migration and invasion through regulation of Rac1.
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Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion.
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Rab23 promotes squamous cell carcinoma cell migration and invasion via integrin ?1/Rac1 pathway.
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Rab23 promotes the cisplatin resistance of ovarian cancer via the Shh-Gli-ABCG2 signaling pathway.
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RAB23, regulated by miR-92b, promotes the progression of esophageal squamous cell carcinoma.
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Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress.
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Rab25 Small GTPase Mediates Secretion of Tumor Necrosis Factor Receptor Superfamily Member 11b (osteoprotegerin) Protecting Cancer Cells from Effects of TRAIL.
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Rab25 upregulation correlates with the proliferation, migration, and invasion of renal cell carcinoma.
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Rab27A mediated by NF-?B promotes the stemness of colon cancer cells via up-regulation of cytokine secretion.
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Rab27A overexpression promotes bladder cancer proliferation and chemoresistance through regulation of NF-?B signaling.
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RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.
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Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression.
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RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
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RAB27A-dependent release of exosomes by liver cancer stem cells induces Nanog expression in their differentiated progenies and confers regorafenib resistance.
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Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma.
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Rab27b Is a Potential Indicator for Lymph Node Metastasis and Unfavorable Prognosis in Lung Adenocarcinoma.
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Rab27b is a potential predictor for metastasis and prognosis in colorectal cancer.
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RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer.
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Rab35 GTPase: A Central Regulator of Phosphoinositides and F-actin in Endocytic Recycling and Beyond.
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Rab35-dependent extracellular nanovesicles are required for induction of tumour supporting stroma.
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Rab37 in lung cancer mediates exocytosis of soluble ST2 and thus skews macrophages toward tumor-suppressing phenotype.
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Rab37 mediates exocytosis of secreted frizzled-related protein 1 to inhibit Wnt signaling and thus suppress lung cancer stemness.
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RAB38 confers a poor prognosis, associated with malignant progression and subtype preference in glioma.
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RAB38 Facilitates Energy Metabolism and Counteracts Cell Death in Glioblastoma Cells.
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RAB38 is a potential prognostic factor for tumor recurrence in non-small cell lung cancer.
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RAB38 promotes bladder cancer growth by promoting cell proliferation and motility.
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Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.
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RAB7 controls melanoma progression by exploiting a lineage-specific wiring of the endolysosomal pathway.
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Rac GTPase activating protein 1 promotes gallbladder cancer via binding DNA ligase 3 to reduce apoptosis.
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Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin.
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Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts.
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Rac1 and Cdc42 are required for phagocytosis, but not NF-kappaB-dependent gene expression, in macrophages challenged with Pseudomonas aeruginosa.
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Rac1 and Cdc42 GTPases regulate shear stress-driven ?-catenin signaling in osteoblasts.
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Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC).
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Rac1 expression in epithelial ovarian cancer: effect on cell EMT and clinical outcome.
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Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity.
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Rac1/?-Catenin Signalling Pathway Contributes to Trophoblast Cell Invasion by Targeting Snail and MMP9.
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RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGF?1 in the Suppression of Cell Motility.
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RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression.
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RacGAP1 ameliorates acute kidney injury by promoting proliferation and suppressing apoptosis of renal tubular cells.
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RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.
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Rad GTPase inhibits the NF?B pathway through interacting with RelA/p65 to impede its DNA binding and target gene transactivation.
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Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.
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Radiation-associated and 'spontaneous' human thyroid carcinomas show a different pattern of ras oncogene mutation.
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Radiation-induced cell transformation: transformation efficiencies of different types of ionizing radiation and molecular changes in radiation transformants and tumor cell lines.
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Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.
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Radiosensitivity of small-cell lung cancer xenografts compared with activity of c-myc, N-myc, L-myc, c-raf-1 and K-ras proto-oncogenes.
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Radiosensitization of human tumor cell lines induced by the adenovirus-mediated expression of an anti-Ras single-chain antibody fragment.
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Radiosensitizing Effects of the Prenyltransferase Inhibitor AZD3409 against RAS Mutated Cell Lines.
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RAF dimer inhibition enhances the antitumor activity of MEK inhibitors in K-RAS mutant tumors.
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Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.
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Ral GTPase down-regulation stabilizes and reactivates p53 to inhibit malignant transformation.
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RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling.
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RAN and YBX1 are required for cell proliferation and IL-4 expression and linked to poor prognosis in oral squamous cell carcinoma.
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Ran, a small GTPase gene, encodes cytotoxic T lymphocyte (CTL) epitopes capable of inducing HLA-A33-restricted and tumor-reactive CTLs in cancer patients.
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Rap GTPase Interactor: A Potential Marker for Cancer Prognosis Following Kidney Transplantation.
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Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression.
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Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins.
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Rap1A promotes esophageal squamous cell carcinoma metastasis through the AKT signaling pathway.
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Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
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Rap1b enhances the invasion and migration of hepatocellular carcinoma cells by up-regulating Twist 1.
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RAP1B, a DVL2 binding protein, activates Wnt/beta-catenin signaling in esophageal squamous cell carcinoma.
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Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.
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RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway.
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Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
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Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner.
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Rapamycin Prevents Early Onset of Tumorigenesis in an Oral-Specific K-ras and p53 Two-Hit Carcinogenesis Model.
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Rapid detection of K-ras gene mutations in canine lung cancer using single-strand conformational polymorphism analysis.
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Rapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresis.
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Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer.
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Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
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ras gene activation and infrequent mutation in papillary serous carcinoma of the peritoneum.
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Ras gene activation in malignant cells of human ovarian carcinoma peritoneal fluids.
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ras gene activation in rat tumors induced by benzidine congeners and derived dyes.
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ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas.
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Ras gene mutations in intraductal papillary neoplasms of the pancreas. Analysis in five cases.
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Ras mutation cooperates with ?-catenin activation to drive bladder tumourigenesis.
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Ras mutational status is a biomarker for resistance to EGFR inhibitors in colorectal carcinoma.
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RAS Mutations Affect Tumor Necrosis Factor-Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects.
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Ras mutations are uncommon in sporadic thyroid cancer in children and young adults.
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ras mutations in 2-acetylaminofluorene-induced lung and liver tumors from C3H/HeJ and (C3H x A/J)F1 mice.
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Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours.
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Ras oncogene activation during hepatocarcinogenesis in B6C3F1 male mice by dichloroacetic and trichloroacetic acids.
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ras proto-oncogene activation in dichloroacetic acid-, trichloroethylene- and tetrachloroethylene-induced liver tumors in B6C3F1 mice.
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Ras proto-oncogene activation in liver and lung tumors from B6C3F1 mice exposed chronically to methylene chloride.
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Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.
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RasGRP1 transgenic mice develop cutaneous squamous cell carcinomas in response to skin wounding: potential role of granulocyte colony-stimulating factor.
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RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors.
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RASL11B gene enhances hyaluronic acid-mediated chondrogenic differentiation in human amniotic mesenchymal stem cells via the activation of Sox9/ERK/smad signals.
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RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.
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RASSF1A methylation and K-ras and B-raf mutations and recurrent endometrial cancer.
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RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.
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Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells.
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Rce1 suppresses invasion and metastasis of hepatocellular carcinoma via epithelial-mesenchymal transition induced by the TGF-?1/H-Ras signaling pathway.
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Re: Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
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Reactive oxygen species and lung tumorigenesis by mutant K-ras: a working hypothesis.
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Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development.
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Reappraisal of K-ras and p53 gene mutations in the recurrence of Dukes' B2 rectal cancer after curative resection.
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Recent Advances in Identifying Biomarkers and High-Affinity Aptamers for Gynecologic Cancers Diagnosis and Therapy.
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Recent progress in developing small molecule inhibitors designed to interfere with ras membrane association: toward inhibiting K-Ras and N-Ras functions.
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Recent progress in targeting the Raf/MEK/ERK pathway with inhibitors in cancer drug discovery.
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Recombinant adenovirus encoding H-ras ribozyme induces apoptosis in laryngeal cancer cells through caspase- and mitochondria-dependent pathways.
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Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
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Recurrent breast cancer and an adenocarcinoma of the lung occurring in one patient: c-myc oncogene amplification and K-ras codon 12 point mutation as tumour markers.
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Redox biology in normal cells and cancer: Restoring function of the redox/Fyn/c-Cbl pathway in cancer cells offers new approaches to cancer treatment.
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Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.
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Reduced likelihood of metastases in patients with microsatellite-unstable colorectal cancer.
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Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.
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Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
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Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.
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Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets.
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Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates.
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Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
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Regulation of CXCR4/AKT-signaling-induced cell invasion and tumor metastasis by RhoA, Rac-1, and Cdc42 in human esophageal cancer.
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Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains.
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Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer.
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Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin.
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Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling.
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Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells.
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Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia.
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Relationship Between Expression of ras p21 Oncoprotein and Mutation Status of the K-ras Gene in Sporadic Colorectal Cancer Patients in Tunisia.
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Relationship between K-ras oncogene activation and smoking in adenocarcinoma of the human lung.
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Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients.
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Relationship between the formation of promutagenic adducts and the activation of the K-ras protooncogene in lung tumors from A/J mice treated with nitrosamines.
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Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
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Relationship of levels and kinetics of H-ras expression to transformed phenotype and loss of TGF-beta 1-mediated growth regulation in intestinal epithelial cells.
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Relationship of the K-ras/c-mos expression patterns with angiogenesis in non-small cell lung carcinomas.
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Relationships of DNA adduct formation, K-ras activating mutations and tumorigenic activities of 6-nitrochrysene and its metabolites in the lungs of CD-1 mice.
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Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
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Release of tumor necrosis factor-á from macrophages is mediated by small GTPase Rab37.
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Relevance of Ras gene mutations in the context of the molecular heterogeneity of multiple myeloma.
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Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics.
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Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway crosstalk in glioma.
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Repositioning metformin in cancer: genetics, drug targets, and new ways of delivery.
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Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis.
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Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop.
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Response to erlotinib in a patient with lung adenocarcinoma harbouring the EML4-ALK translocation: A case report.
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Response to First-Line Chemotherapy in Patients With Non-Small-Cell Lung Cancer According to Epidermal Growth Factor Receptor and K-RAS Mutation Status.
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Restoration of thrombospondin 1 expression in tumor cells harbouring mutant ras oncogene by treatment with low doses of doxycycline.
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Restriction endonuclease-mediated selective polymerase chain reaction: a novel assay for the detection of K-ras mutations in clinical samples.
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Results of a Phase I Trial of 12 Patients With Locally Advanced Pancreatic Carcinoma Combining Gefitinib, Paclitaxel, and 3-Dimensional Conformal Radiation: Report of Toxicity and Evaluation of Circulating K-ras as a Potential Biomarker of Response to Therapy.
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Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
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Resveratrol inhibits proliferation and migration through SIRT1 mediated post?translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells.
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Retraction: "Activated K-Ras and INK4a/Arf Deficiency Promote Aggressiveness of Pancreatic Cancer by Induction of EMT Consistent With Cancer Stem Cell Phenotype" by Wang et al.
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Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype.
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Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
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Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion.
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Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers.
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Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters.
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Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology.
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Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis.
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Rho-associated kinase inhibitor reduces tumor recurrence after liver transplantation in a rat hepatoma model.
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Rho-GTPase effector ROCK phosphorylates cofilin in actin-meditated cytokinesis during mouse oocyte meiosis.
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Rho-kinase/ROCK is involved in cytokinesis through the phosphorylation of myosin light chain and not ezrin/radixin/moesin proteins at the cleavage furrow.
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Rho/ROCK/actin signaling regulates membrane androgen receptor induced apoptosis in prostate cancer cells.
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Rho?associated kinase inhibitor, Y?27632, inhibits the invasion and proliferation of T24 and 5367 bladder cancer cells.
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RhoA controls retinoid signaling by ROCK dependent regulation of retinol metabolism.
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RHOA G17V Induces T Follicular Helper Cell Specification and Promotes Lymphomagenesis.
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RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer.
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RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells.
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RhoB differentially controls Akt function in tumor cells and stromal endothelial cells during breast tumorigenesis.
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RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3.
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RhoC mediates invasion and migration of CaSki cells through the Rho-associated serine-threonine protein kinase 1 signaling pathway.
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RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain.
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RhoGDI SUMOylation at K138 Increases Its Binding Activity to Rho GTPase and its Inhibiting Cancer Cell Motility.
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RhoGDI{alpha}-dependent balance between RhoA and RhoC is a key regulator of cancer cell tumorigenesis.
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RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
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RhoGTPases and Rho-effectors in hepatocellular carcinoma metastasis: ROCK N'Rho move it.
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RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.
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Rhoj Is a Novel Target for Progression and Invasion of Glioblastoma by Impairing Cytoskeleton Dynamics.
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Ribonucleotide reductase R2 gene expression and changes in drug sensitivity and genome stability.
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RInhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
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Risk for K-ras gene mutations in smoking-induced lung cancer is associated with cytochrome P4501A1 and glutathione S-transferase micro1 polymorphisms.
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RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells.
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Rock2 promotes RCC proliferation by decreasing SCARA5 expression through ?-catenin/TCF4 signaling.
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Rock2 stabilizes ?-catenin to promote tumor invasion and metastasis in colorectal cancer.
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Role of BamHI-A Rightward Frame 1 in Epstein-Barr Virus-Associated Epithelial Malignancies.
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Role of Clara cells and type II cells in the development of pulmonary tumors in rats and mice following exposure to a tobacco-specific nitrosamine.
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Role of DNA methylation in the activation of proto-oncogenes and the induction of pulmonary neoplasia by nitrosamines.
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Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer.
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Role of H-ras gene in chronic liver damage in mice. By using transgenic mice carrying a human C-H-ras proto-oncogene without mutations.
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Role of Necl-5 in the pathophysiology of colorectal lesions induced by dimethylhydrazine and/or dextran sodium sulphate.
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Role of oncogenic K-Ras in cancer stem cell activation by aberrant Wnt/?-catenin signaling.
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Role of point mutation of the K-ras gene in tumorigenesis of B6C3F1 mouse lung lesions induced by urethane.
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Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation.
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Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma.
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Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of ?-Tocotrienol on Mammary Cancer Cell Migration and Invasion.
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Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
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Role of Rap1B and Tumor Suppressor PTEN in the Negative Regulation of Lysophosphatidic Acid-induced Migration by Isoproterenol in Glioma Cells.
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Role of ras protooncogene activation in the formation of spontaneous and nitrosamine-induced lung tumors in the resistant C3H mouse.
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Role of the DPC4 tumor suppressor gene in adenocarcinoma of the ampulla of Vater: analysis of 140 cases.
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Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer.
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Roles of E-cadherin and Noncoding RNAs in the Epithelial-mesenchymal Transition and Progression in Gastric Cancer.
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Roles of Small GTPases in Acquired Tamoxifen Resistance in MCF-7 Cells Revealed by Targeted, Quantitative Proteomic Analysis.
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RRAD inhibits the Warburg effect through negative regulation of the NF-?B signaling.
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Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.
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S-Adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
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S-adenosylmethionine decarboxylase gene expression is regulated by the cAMP signal transduction pathway in H-ras transformed fibrosarcoma cells capable of malignant progression.
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S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.
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S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
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Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity.
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Sampling technique influences the detection of K-ras mutations in normal appearing mucosa of colorectal cancer patients.
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Saponins extracted from by-product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway.
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Saponins extracted from by?product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway
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Screening for Combination Cancer Therapies With Dynamic Fuzzy Modeling and Multi-Objective Optimization.
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Screening of human bladder tumors and urine sediments for the presence of H-ras mutations.
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Second primary or recurrence? Comparative patterns of p53 and K-ras mutations suggest that serous borderline ovarian tumors and subsequent serous carcinomas are unrelated tumors.
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Secondary malignant giant-cell tumour of bone: molecular abnormalities of p53 and H-ras gene correlated with malignant transformation.
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Selective 'stencil'-aided pre-PCR cleavage of wild-type sequences as a novel approach to detection of mutant K-RAS.
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Selective control of membrane ruffling and actin plaque assembly by the Rho GTPases Rac1 and CDC42 in FcepsilonRI-activated rat basophilic leukemia (RBL-2H3) cells.
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Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: potential involvement of H-Ras downregulation.
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Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
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Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress.
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Selective killing of K-ras-transformed pancreatic cancer cells by targeting NAD(P)H oxidase.
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Selective mutation of K-ras by N-ethylnitrosourea shifts from codon 12 to codon 61 during fetal mouse lung maturation.
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Selective occurrence of ras mutations in benign and malignant thyroid follicular neoplasms in Taiwan.
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Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics.
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Sensitive and specific detection of K-ras mutations in colon tumors by short oligonucleotide mass analysis.
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Sensitive and specific KRAS somatic mutation analysis on whole-genome amplified DNA from archival tissues.
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Sensitive detection of intracellular environment of normal and cancer cells by autofluorescence lifetime imaging.
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Sensitive detection of K-ras mutations augments diagnosis of colorectal cancer metastases in the liver.
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Sensitization of Human Pancreatic Cancer Cells Harboring Mutated K-ras to Apoptosis.
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SEPT9_i1 regulates human breast cancer cell motility through cytoskeletal and RhoA/FAK signaling pathway regulation.
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Sequence Distribution of Acetaldehyde-Derived N(2)-Ethyl-dG Adducts along Duplex DNA.
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Sequential accumulation of K-ras mutations and p53 overexpression in the progression of pancreatic mucinous cystic neoplasms to malignancy.
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Sequential analysis of K-ras mutations in aberrant crypt foci and colonic tumors induced by azoxymethane in Fischer-344 rats on high-risk diet.
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Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library.
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Sex differences in clinicopathological features of peripheral T1 adenocarcinoma of the lung.
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Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer.
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Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins.
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Signet ring basal cell carcinoma. A case study emphasizing the differential diagnosis of neoplasms with signet ring cell formation.
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Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
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Significantly increased cortisol secretion in normal adrenocortical cells transfected with K-ras mutants derived from human functional adrenocortical tumors.
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Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
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Silibinin Inhibit Cell Migration through Downregulation of RAC1 Gene Expression in Highly Metastatic Breast Cancer Cell Line.
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Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment.
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Simultaneous genotyping of multiplex single nucleotide polymorphisms of the K-ras gene with a home-made kit.
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Single-Pattern Convergence of K-ras Mutation Correlates With Surgical Indication of Intraductal Papillary Mucinous Neoplasms.
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Single-strand conformation polymorphism analysis by perpendicular temperature-gradient gel electrophoresis.
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siRNA-Encapsulated Hybrid Nanoparticles Target Mutant K-ras and Inhibit Metastatic Tumor Burden in a Mouse Model of Lung Cancer.
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Site specificity of N-methyl-N-nitrosourea-induced transition mutations in the hprt gene.
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Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
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Six-month exposure of strain A/J mice to cigarette sidestream smoke: cell kinetics and lung tumor data.
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Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter.
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Small advanced colorectal cancers: clinicopathological characteristics and pathogenetic origin.
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Small G protein signalling modulator 2 (SGSM2) is involved in oestrogen receptor-positive breast cancer metastasis through enhancement of migratory cell adhesion via interaction with E-cadherin.
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Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.
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Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis.
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Small GTPase RBJ mediates nuclear entrapment of MEK1/MEK2 in tumor progression.
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Small interfering RNAs targeting mutant K-ras inhibit human pancreatic carcinoma cells growth in vitro and in vivo.
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Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
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Small rho GTPases mediate tumor-induced inhibition of endocytic activity of dendritic cells.
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Sodium nitroprusside induces H-Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells.
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Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations.
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Somatic mutation screening: identification of individuals harboring K-ras mutations with the use of plasma DNA.
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Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas.
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Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.
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Sos-mediated cross-activation of wild-type Ras by oncogenic Ras is essential for tumorigenesis.
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Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects.
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Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype.
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Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.
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Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA.
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Specific repression of mutant K-RAS by 10-23 DNAzyme: sensitizing cancer cell to anti-cancer therapies.
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Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis.
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Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy.
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Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation.
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Sprouty2 protein enhances the response to gefitinib through epidermal growth factor receptor in colon cancer cells.
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srGAP1 mediates the migration inhibition effect of Slit2-Robo1 in colorectal cancer.
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Stability of c-K-ras amplification during progression in a patient with adenocarcinoma of the ovary.
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Stability of K-ras mutations throughout the natural history of human colorectal cancer.
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STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone.
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Stimulated human leukocytes cause activating mutations in the K-ras protooncogene.
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Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity.
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Stimulation of Ectopic Bone Formation in Response to BMP-2 by Rho Kinase Inhibitor: A Pilot Study.
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Strategies for Overcoming Inherent and Acquired Resistance to EGFR Inhibitors by Targeting Downstream Effectors in the RAS/PI3K Pathway.
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Stromal cells of endometrial carcinoma promotes proliferation of epithelial cells through the HGF/c-Met/Akt signaling pathway.
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Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations.
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Structure based drug discovery of Rab38 protein- Identification of antagonists as cancer drug candidates.
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Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDE? prenyl binding site.
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Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth.
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Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation.
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Study of the correlation between H-ras mutation and primary hepatocellular carcinoma.
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Subunit peptide cancer vaccines targeting activating mutations of the p21 ras proto-oncogene.
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Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.
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Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer.
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Suppression of anoikis by v-Src but not by activated c-H-ras in human gallbladder epithelial cells.
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Suppression of colorectal oncogenesis by selenium-enriched milk proteins: apoptosis and K-ras mutations.
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Suppression of Egr-1 transcription through targeting of the serum response factor by oncogenic H-Ras.
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Suppression of Erk activation and in vivo growth in esophageal cancer cells by the dominant negative Ras mutant, N116Y.
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Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene.
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Suppression of non-small cell lung tumor development by the let-7 microRNA family.
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Suppression of various human tumor cell lines by a dominant negative H-ras mutant.
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Suppressive effect of modified dominant negative RAS mutant on human cancer by gene transfer with non-viral vector.
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Surgical treatment of hepatocellular carcinoma and related basic research with special reference to recurrence and metastasis.
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Survivin depletion preferentially reduces the survival of activated K-Ras-transformed cells.
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Sustained inhibition of tumor growth and prolonged survival following sequential administration of doxorubicin and zoledronic acid in a breast cancer model.
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Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through ?2?1 integrin and MT1-MMP.
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Synergism between K-rasVal12 and mutant Apc accelerates murine large intestinal tumourigenesis.
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Synergistic effect of MNU and DMBA in mammary carcinogenesis and H-ras activation in female Sprague-Dawley rats.
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Synthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: sulfonamido derivatives as inhibitors of Ras prenylation.
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Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.
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Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
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Synthetic miR-143 Exhibited an Anti-Cancer Effect via the Downregulation of K-RAS Networks of Renal Cell Cancer Cells In Vitro and In Vivo.
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Systematic approach identifies RHOA as a potential biomarker therapeutic target for Asian gastric cancer.
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Systemic cytotoxic and biological therapies of colorectal liver metastases: expert consensus statement.
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Systems-wide analysis of K-Ras, Cdc42, and PAK4 signaling by quantitative phosphoproteomics.
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T-RMSD: a fine-grained, structure-based classification method and its application to the functional characterization of TNF receptors.
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Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA.
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Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
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Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice.
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Targeted Quantitative Proteomics Revealed Arsenite-induced Proteasomal Degradation of RhoB in Fibroblast Cells.
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Targeting ?-catenin in hepatocellular cancers induced by coexpression of mutant ?-catenin and K-Ras in mice.
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Targeting Cdc42 with the anticancer compound MBQ-167 inhibits cell polarity and growth in the budding yeast S. cerevisiae.
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Targeting Cdc42 with the small molecule drug AZA197 suppresses primary colon cancer growth and prolongs survival in a preclinical mouse xenograft model by downregulation of PAK1 activity.
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Targeting geranylgeranylation reduces adrenal gland tumor burden in a murine model of prostate cancer metastasis.
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Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer.
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Targeting interferon signaling and CTLA-4 enhance the therapeutic efficacy of anti-PD-1 immunotherapy in preclinical model of HPV+ oral cancer.
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Targeting Lactate Dehydrogenase-A Inhibits Tumorigenesis and Tumor Progression in Mouse Models of Lung Cancer and Impacts Tumor-Initiating Cells.
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Targeting NRAS(Q61K) mutant delays tumor growth and angiogenesis in non-small cell lung cancer.
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Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice.
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Targeting oncogenic KRAS in non-small cell lung cancer cells by phenformin inhibits growth and angiogenesis.
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Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.
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Targeting PI3K Pathway in Pancreatic Ductal Adenocarcinoma: Rationale and Progress.
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Targeting plasma membrane phosphatidylserine content to inhibit oncogenic KRAS function.
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Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.
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Targeting the ?4-?5 dimerization interface of K-RAS inhibits tumor formation in vivo.
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Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.
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Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
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Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.
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Targeting the Wnt Pathway and Cancer Stem Cells with Anti-progastrin Humanized Antibodies as a Potential Treatment for K-RAS-Mutated Colorectal Cancer.
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Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication.
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Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer.
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Telomerase activity and Bcl-2 expression in gallbladders of pancreaticobiliary maljunction patients: a preliminary study.
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Temporal changes in the mutant frequency and mutation spectra of the 61st codon of the H-ras oncogene following exposure of B6C3F1 mice to N-nitrosodiethylamine (DEN).
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TGF-? acts as a dual regulator of COX-2/PGE2 tumor promotion depending of its cross-interaction with H-Ras and Wnt/?-catenin pathways in colorectal cancer cells.
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TGF-?1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK.
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The Accumulation of Multiple Genetic Abnormalities in Individual Tumor Cells in Human Breast Cancers: Clinical Prognostic Implications
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The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma.
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The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.
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The association between a mutated ras gene and cyclooxygenase-2 expression in human breast cancer cell lines.
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The Association Between Selected Risk Factors for Pancreatic Cancer and the Expression of p53 and K-ras Codon 12 Mutations.
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The association of K-ras gene mutation and vascular endothelial growth factor gene expression in pancreatic carcinoma.
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The association of the H-ras oncogene and steroid hormone receptors in gynecological cancer.
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The balanced induction of K-ras codon 12 and 13 mutations in mucosa differs from their ratio in neoplastic tissues.
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The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts.
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The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.
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The brain microenvironment negatively regulates miRNA-768-3p to promote K-ras expression and lung cancer metastasis.
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The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells.
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The caM kinase, Pnck, is spatially and temporally regulated during murine mammary gland development and may identify an epithelial cell subtype involved in breast cancer.
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The Cdc42 Effector Kinase PAK4 Localizes to Cell-Cell Junctions and Contributes to Establishing Cell Polarity.
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The CDC42-specific inhibitor derived from ACK-1 blocks v-Ha-Ras-induced transformation.
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The clinicopathological significance of K-RAS point mutation and gene amplification in endometrial cancer.
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The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma.
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The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting.
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The differential effects of wildtype and mutated K-Ras on MST2 signalling are determined by K-Ras activation kinetics.
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The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients.
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The discovery and maturation of peptide biologics targeting the small G-protein Cdc42: A bioblockade for Ras-driven signaling.
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The drs tumor suppressor regulates glucose metabolism via lactate dehydrogenase-B.
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The dual functions of Rab11 and Rab35 GTPases-regulation of cell division and promotion of tumorigenicity.
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The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets.
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The dynamic nature of the K-Ras/calmodulin complex can be altered by oncogenic mutations.
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The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment.
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The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.
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The effect of gefitinib on B-RAF mutant non-small cell lung cancer and transfectants.
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The effects of a binary mixture of benzo(a)pyrene and 7H-dibenzo(c,g)carbazole on lung tumors and K-ras oncogene mutations in strain A/J mice.
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The effects of cigarette smoking extracts on cell cycle and tumor spread: novel evidence.
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The evolving role of monoclonal antibodies in colorectal cancer: early presumptions and impact on clinical trial development.
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The farnesyl transferase inhibitor RPR-130401 does not alter radiation susceptibility in human tumor cells with a K-Ras mutation in spite of large changes in ploidy and lamin B distribution.
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The farnesyl transferase inhibitor SCH 66336 induces a G(2) --> M or G(1) pause in sensitive human tumor cell lines.
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The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts.
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The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
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The frequency of p53, K-ras mutations, and microsatellite instability differs in uterine endometrioid and serous carcinoma: evidence of distinct molecular genetic pathways.
Neoplasms
The growth and tumor suppressor novel ras effector 1A (NORE1A) is a regulatory node between ras signaling and microtubule nucleation.
Neoplasms
The guanine triphosphatase (GTPase) activating protein (GAP)-related domain of the neurofibromatosis type 1 gene is not mutated in neural crest-derived sporadic tumours.
Neoplasms
The H-ras oncogene regulates expression of 70- and 45-kDa cell-surface molecules whose expression correlates with tumor-cell immunogenicity.
Neoplasms
The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells.
Neoplasms
The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA.
Neoplasms
The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.
Neoplasms
The K-Ras effector p38? MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation.
Neoplasms
The K-ras gene regulates vascular endothelial growth factor gene expression in non-small cell lung cancers.
Neoplasms
The let-7a microRNA protects from growth of lung carcinoma by suppression of k-Ras and c-Myc in nude mice.
Neoplasms
The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted.
Neoplasms
The mammalian ribonucleotide reductase R2 component cooperates with a variety of oncogenes in mechanisms of cellular transformation.
Neoplasms
The metastasis-associated gene CD24 is regulated by Ral GTPase and is a mediator of cell proliferation and survival in human cancer.
Neoplasms
The microdomain-organizing protein MPP1 is required for insulin-stimulated activation of H-Ras.
Neoplasms
The miR-18a* microRNA functions as a potential tumor suppressor by targeting on K-Ras.
Neoplasms
The MLK-related Kinase (MRK) Is a Novel RhoC Effector That Mediates Lysophosphatidic Acid (LPA)-stimulated Tumor Cell Invasion.
Neoplasms
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-?B and RalB signaling pathways.
Neoplasms
The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance.
Neoplasms
The National Toxicology Program evaluation of genetically altered mice as predictive models for identifying carcinogens.
Neoplasms
The noncoding RNAs SNORD50A and SNORD50B bind K-Ras and are recurrently deleted in human cancer.
Neoplasms
The oncogenic mutation in the pleckstrin homology domain of AKT1 in endometrial carcinomas.
Neoplasms
The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.
Neoplasms
The pattern of K-ras mutation in pulmonary adenocarcinoma defines a new pathway of tumour development in the human lung.
Neoplasms
The Pivotal Roles of the Epithelial Membrane Protein Family in Cancer Invasiveness and Metastasis.
Neoplasms
The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region.
Neoplasms
The presence of K-12 ras mutations in duodenal adenocarcinomas and the absence of ras mutations in other small bowel adenocarcinomas and carcinoid tumors.
Neoplasms
The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.
Neoplasms
The prognostic impact of RAP2A expression in patients with early and locoregionally advanced nasopharyngeal carcinoma in an endemic area.
Neoplasms
The prognostic significance of K-ras, p53, and APC mutations in colorectal carcinoma.
Neoplasms
The prognostic significance of p63 cytoplasmic expression in colorectal cancer. An immunohistochemical study.
Neoplasms
The prognostic significance of tumor-associated markers p53, HER-2/neu, c-myc, v-H-ras, PCNA and EGFr of local and distant recurrence in localized human prostatic adenocarcinoma.
Neoplasms
The proliferation of multiple myeloma colonies (MY-CFUc) in vitro is independent of prognosis and is not associated with mutated N- or K-ras alleles in human bone marrow aspirates.
Neoplasms
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Neoplasms
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
Neoplasms
The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster.
Neoplasms
The Ras-membrane Interface: Isoform-specific Differences in the Catalytic Domain.
Neoplasms
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.
Neoplasms
The Ras-related protein, Rap1A, mediates thrombin-stimulated, integrin-dependent glioblastoma cell proliferation and tumor growth.
Neoplasms
The Rb-E2F transcriptional regulatory pathway in tumor angiogenesis and metastasis.
Neoplasms
The relationship between 1,2-dimethylhydrazine dose and the induction of colon tumours: tumour development in female SWR mice does not require a K-ras mutational event.
Neoplasms
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
Neoplasms
The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.
Neoplasms
The Rho GTPase Rac1 is required for recycling endosome-mediated secretion of TNF in macrophages.
Neoplasms
The Rho GTPase RhoB regulates cadherin expression and epithelial cell-cell interaction.
Neoplasms
The Rho GTPase RhoE is a p53-regulated candidate tumor suppressor in cancer cells.
Neoplasms
The role of ARHGAP9: clinical implication and potential function in acute myeloid leukemia.
Neoplasms
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
Neoplasms
The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium.
Neoplasms
The role of hyperplastic nodules in dichloroacetic acid-induced hepatocarcinogenesis in B6C3F1 male mice.
Neoplasms
The role of K-Ras gene mutation in TRAIL-induced apoptosis in pancreatic and lung cancer cell lines.
Neoplasms
The role of molecular analysis in the diagnosis and surveillance of pancreatic cystic neoplasms.
Neoplasms
The role of p19 and p21 H-Ras proteins and mutants in miRNA expression in cancer and a Costello syndrome cell model.
Neoplasms
The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology.
Neoplasms
The role of pharmacogenetics in adjuvant treatment of non-small cell lung cancer.
Neoplasms
The role of Rho GTPases' substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study.
Neoplasms
The role of sema4D in vasculogenic mimicry formation in non-small cell lung cancer and the underlying mechanisms.
Neoplasms
The role of TGF-? and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma.
Neoplasms
The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.
Neoplasms
The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells.
Neoplasms
The second intron of the K-ras gene contains regulatory elements associated with mouse lung tumor susceptibility.
Neoplasms
The small GTPase ARF6 regulates protein trafficking to control cellular function during development and in disease.
Neoplasms
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells.
Neoplasms
The small GTPase Rac1 links the Kaposi sarcoma-associated herpesvirus vGPCR to cytokine secretion and paracrine neoplasia.
Neoplasms
The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours.
Neoplasms
The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells.
Neoplasms
The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.
Neoplasms
The structure and function of the H-ras proto-oncogene are not altered in rat liver tumors initiated by 2-acetylaminofluorene, 2-acetylaminophenanthrene and trans-4-acetylaminostilbene.
Neoplasms
The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration.
Neoplasms
The TGF-{beta} co-receptor endoglin modulates the expression and transforming potential of H-Ras.
Neoplasms
The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.
Neoplasms
The trihelical bundle subdomain of the GGA proteins interacts with multiple partners through overlapping but distinct sites.
Neoplasms
The tumor suppressor DiRas3 forms a complex with H-Ras and C-RAF proteins and regulates localization, dimerization, and kinase activity of C-RAF.
Neoplasms
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
Neoplasms
The tumor suppressor protein DLC1 is regulated by PKD-mediated GAP domain phosphorylation.
Neoplasms
The tumour suppressor DLC2 ensures mitotic fidelity by coordinating spindle positioning and cell-cell adhesion.
Neoplasms
The type III TGF-{beta} receptor regulates epithelial and cancer cell migration through {beta}-arrestin2-mediated activation of Cdc42.
Neoplasms
The type III TGFbeta receptor regulates directional migration: new tricks for an old dog.
Neoplasms
The type III TGF? receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
Neoplasms
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Neoplasms
The v-mos and H-ras oncogene expression represses glucocorticoid hormone-dependent transcription from the mouse mammary tumor virus LTR.
Neoplasms
The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy.
Neoplasms
Therapeutic Effect of Y-27632 on Tumorigenesis and Cisplatin-Induced Peripheral Sensory Loss through RhoA-NF-?B.
Neoplasms
Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer.
Neoplasms
Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis.
Neoplasms
Three-dimensional culture of a mixed mullerian tumor of the ovary: expression of in vivo characteristics.
Neoplasms
Thyroid hemiagenesis, Graves' disease and differentiated thyroid cancer: a very rare association: case report and review of literature.
Neoplasms
Time-dependent biological differences in molecular markers of high-grade urothelial cancer over 7 decades (ras proteins, pTEN, uPAR, PAI-1 and MMP-9).
Neoplasms
Time-serial Assessment of Drug Combination Interventions in a Mouse Model of Colorectal Carcinogenesis Using Optical Coherence Tomography.
Neoplasms
Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer.
Neoplasms
Tissue factor expression in non-small cell lung cancer: relationship with vascular endothelial growth factor expression, microvascular density, and K-ras mutation.
Neoplasms
Tissue sampling for mutation analysis in colorectal cancer: K-ras is homogeneously distributed throughout the tumor tissue.
Neoplasms
Tissue-specific expression of the K-ras allele from the A/J parent in (A/J x TSG-p53) F1 mice.
Neoplasms
TNF-?/NF-?B signaling epigenetically represses PSD4 transcription to promote alcohol-related hepatocellular carcinoma progression.
Neoplasms
Tobacco smoke promotes lung tumorigenesis by triggering IKKbeta- and JNK1-dependent inflammation.
Neoplasms
Tobacco smoke-induced lung tumorigenesis in mutant A/J mice with alterations in K-ras, p53, or Ink4a/Arf.
Neoplasms
Tools to study the function of the Ras-related, estrogen-regulated growth inhibitor in breast cancer.
Neoplasms
Topological and quantitative-analyses of early events in tumor-formation using histochemically-tagged transformed 3t3 cells.
Neoplasms
Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer--an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009.
Neoplasms
TP53 and RAS mutations in metachronous tumors from patients with cancer of the upper aerodigestive tract.
Neoplasms
Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Neoplasms
Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.
Neoplasms
Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors.
Neoplasms
Transcriptional control of the human high mobility group A1 gene: basal and oncogenic Ras-regulated expression.
Neoplasms
Transcriptional regulation of the c-H-ras1 gene by the P53 protein is implicated in the development of human endometrial and ovarian tumours.
Neoplasms
Transcriptional signatures of Ral GTPase are associated with aggressive clinicopathologic characteristics in human cancer.
Neoplasms
Transcriptional switching model for the regulation of tumorigenesis and metastasis by the ha-ras oncogene - transcriptional changes in the ha-ras tumor-suppressor gene lysyl oxidase.
Neoplasms
Transfection of K-rasAsp12 cDNA markedly elevates IL-1beta- and lipopolysaccharide-mediated inducible nitric oxide synthase expression in rat intestinal epithelial cells.
Neoplasms
Transformation of Epstein-Barr virus immortalized human B-cells by chemical carcinogens.
Neoplasms
Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro.
Neoplasms
Transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium-uranyl chloride.
Neoplasms
Transformation of mouse skin endothelial cells in vivo by direct application of plasmid DNA encoding the human T24 H-ras oncogene.
Neoplasms
Transforming growth factor beta expression and transformation of rat lung epithelial cells by crystalline silica (quartz).
Neoplasms
Transforming growth factor-beta1 modulates metalloproteinase-2 and -9, nitric oxide, RhoA and alpha-smooth muscle actin expression in colon adenocarcinoma cells.
Neoplasms
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Neoplasms
Transglutaminase-2, RNA-binding proteins and mitochondrial proteins selectively traffic to MDCK cell-derived microvesicles following H-Ras-induced epithelial-mesenchymal transition.
Neoplasms
Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.
Neoplasms
Transient Exposure of Mammary Tumors to PD184352 and UCN-01 Causes Tumor Cell Death In Vivo and Prolonged Suppression of Tumor Regrowth.
Neoplasms
Transition from squamous cell carcinoma to adenocarcinoma in adenosquamous carcinoma of the lung.
Neoplasms
Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.
Neoplasms
Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver.
Neoplasms
Transplacental mutagenicity of cisplatin: H-ras codon 12 and 13 mutations in skin tumors of SENCAR mice.
Neoplasms
Trisomy 12 correlates with elevated expression of p21 ras in a human adenosquamous carcinoma of the lung.
Neoplasms
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer.
Neoplasms
Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: impact of K-ras mutations.
Neoplasms
Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients.
Neoplasms
Tumor endothelial marker 5 expression in endothelial cells during capillary morphogenesis is induced by the small GTPase Rac and mediates contact inhibition of cell proliferation.
Neoplasms
Tumor gene mutations and messenger RNA expression: correlation with clinical response to icotinib hydrochloride in non-small cell lung cancer.
Neoplasms
Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.
Neoplasms
Tumor location and detection of k-ras mutations in stool from colorectal cancer patients.
Neoplasms
Tumor markers in colorectal cancer, gastric cancer and gastrointestinal stromal cancers: European group on tumor markers 2014 guidelines update.
Neoplasms
Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1.
Neoplasms
Tumor multiplicity, DNA adducts and K-ras mutation pattern of 5-methylchrysene in strain A/J mouse lung.
Neoplasms
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces chemotactic migration of monocytes via a death receptor 4-mediated RhoGTPase pathway.
Neoplasms
Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.
Neoplasms
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
Neoplasms
Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor.
Neoplasms
Tumor Protein p53 and K-ras Gene Mutations in Peruvian Patients with Gallbladder Cancer
Neoplasms
Tumor regression grades, K-RAS mutational profile and c-MET in colorectal liver metastases.
Neoplasms
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis.
Neoplasms
Tumor Suppressive Role of ARHGAP17 in Colon Cancer Through Wnt/?-Catenin Signaling.
Neoplasms
Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A.
Neoplasms
Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.
Neoplasms
Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Neoplasms
Tumorigenesis in colorectal tumors from patients with hereditary non-polyposis colorectal cancer.
Neoplasms
Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras.
Neoplasms
Tumorigenic transformation of spontaneously immortalized fibroblasts from patients with a familial cancer syndrome.
Neoplasms
Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay.
Neoplasms
Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice.
Neoplasms
Tumors induced in mice by direct inoculation of plasmid DNA expressing both activated H-ras and c-myc.
Neoplasms
Tumors of the pancreas with osteoclast-like and pleomorphic giant cells: an immunohistochemical and ploidy study.
Neoplasms
Tumour cell CD99 regulates transendothelial migration via CDC42 and actin remodelling.
Neoplasms
Tumour-derived mutated K-ras codon 12 expression in regional lymph nodes of stage II colorectal cancer patients is not associated with increased risk of cancer-related death.
Neoplasms
Twenty Novel Disease Group-Specific and 12 New Shared Macrophage Pathways in Eight Groups of 34 Diseases Including 24 Inflammatory Organ Diseases and 10 Types of Tumors.
Neoplasms
Type of TP53 mutation influences oncogenic potential and spectrum of associated K-ras mutations in lung-specific transgenic mice.
Neoplasms
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Neoplasms
Ubc9 promotes breast cell invasion and metastasis in a sumoylation-independent manner.
Neoplasms
Ultraviolet B irradiation induces expansion of intraepithelial tumor cells in a tissue model of early cancer progression.
Neoplasms
Understanding the Complexity of the Tumor Microenvironment in K-ras Mutant Lung Cancer: Finding an Alternative Path to Prevention and Treatment.
Neoplasms
Understanding the predictive role of K-ras for epidermal growth factor receptor-targeted therapies in colorectal cancer.
Neoplasms
Unique K-ras mutational pattern in pancreatic adenocarcinoma from Taiwanese patients.
Neoplasms
Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.
Neoplasms
Update on the molecular profile of the MDA-MB-453 cell line as a model for apocrine breast carcinoma studies.
Neoplasms
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Neoplasms
Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastoma.
Neoplasms
Upregulation of miR-582-5p inhibits cell proliferation, cell cycle progression and invasion by targeting Rab27a in human colorectal carcinoma.
Neoplasms
Upregulation of non-mutated H-ras and its upstream and downstream signaling proteins in colorectal cancer.
Neoplasms
Upregulation of ROCK2 in gastric cancer cell promotes tumor cell proliferation, metastasis and invasion.
Neoplasms
Use of avian retroviral vectors to introduce transcriptional regulators into mammalian cells for analyses of tumor maintenance.
Neoplasms
Use of E mu-PIM-1 transgenic mice short-term in vivo carcinogenicity testing: lymphoma induction by benzo[a]pyrene, but not by TPA.
Neoplasms
Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment.
Neoplasms
Use of microsatellite marker loss of heterozygosity in accurate diagnosis of pancreaticobiliary malignancy from brush cytology samples.
Neoplasms
Use of p53 transgenic mice in the development of cancer models for multiple purposes.
Neoplasms
Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer.
Neoplasms
Use of retrovirus expression of interfering RNA to determine the contribution of activated k-ras and ras effector expression to human tumor cell growth.
Neoplasms
Use of spontaneous Epstein-Barr virus-lymphoblastoid cell lines genetically modified to express tumor antigen as cancer vaccines: mutated p21 ras oncogene in pancreatic carcinoma as a model.
Neoplasms
Usefulness of analysis of p53 alteration and observation of surface microstructure for diagnosis of ulcerative colitis-associated colorectal neoplasia.
Neoplasms
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Neoplasms
Usufuleness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Neoplasms
Utilization of K-ras mutations identified in stool DNA for the early detection of colorectal cancer.
Neoplasms
Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial.
Neoplasms
Vaccination with Clostridium perfringens recombinant proteins in combination with Montanide ISA 71 VG adjuvant increases protection against experimental necrotic enteritis in commercial broiler chickens.
Neoplasms
Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation.
Neoplasms
Validation of blood testing for K-ras mutations in colorectal and pancreatic cancer.
Neoplasms
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
Neoplasms
VAMP8, a vesicle-SNARE required for RAB37-mediated exocytosis, possesses a tumor metastasis suppressor function.
Neoplasms
Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.
Neoplasms
Variant mutational activation of the K-ras oncogene in renal mesenchymal tumors induced in newborn F344 rats by methyl(methoxymethyl)nitrosamine.
Neoplasms
Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.
Neoplasms
Vascular endothelial growth factor and nitric oxide synthase expression in human lung cancer and the relation to p53.
Neoplasms
Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.
Neoplasms
Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors.
Neoplasms
VEGF neutralizing aerosol therapy in primary pulmonary adenocarcinoma with K-ras activating-mutations.
Neoplasms
Versatile Role of Rab27a in Glioma: Effects on Release of Extracellular Vesicles, Cell Viability, and Tumor Progression.
Neoplasms
Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42.
Neoplasms
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response.
Neoplasms
Wild-type K-ras has a tumour suppressor effect on carcinogen-induced murine colorectal adenoma formation.
Neoplasms
Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation.
Neoplasms
ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression.
Neoplasms
ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
Neoplasms
["Field cancerization"--an additional phenomenon in development of colon tumors? K-ras codon 12 mutations in normal colonic mucosa of patients with colorectal neoplasms]
Neoplasms
[A case of anal fistula cancer probably developing from intraluminal dissemination of rectal cancer]
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[A Case of Rectal Cancer with Unresectable Liver Metastasis Responding to Rechallenge with FOLFIRI].
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[A case of synchronous cancer of the gall bladder, common bile duct, and the papilla of vater].
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[A case of unresectable multiple hepatic metastases from ascending colon cancer successfully treated with panitumumab and FOLFIRI(5-FU/LV/irinotecan)therapy].
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[A study on the role of DNA repair gene O6-methylguanine-DNA methyltransferase in the development of human lung cancer]
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[Actinic keratoses : Pathogenesis, clinical aspect and modern therapeutic options].
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[Agreement between information supplied by the patient and a family member on medical history, consumption of tobacco, alcohol and coffee and diet in cancer of the exocrine pancreas and extrahepatic biliary tract]
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[Altered Treg and IL-1A Expression in the Immune Microenvironment ?of Lung Squamous-cell Cancer after EGFR Blockade].
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[Analysis of K-ras, BRCA1/2, CHEK2 mutations and microsatellite markers (loss of heterozygosity at 9p, 17p and 18q) in sporadic pancreas adenocarcinomas]
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[Anatomopathological tools for screening and medical surveillance of people exposed to asbestos]
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[Basic studies on mutation analysis of K-ras codon 12 by use of three-dimensional microarray system]
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[Characteristics of plasma DNA and its application for detection of K-ras gene mutation]
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[Clinical analysis of 12 cases of acute myeloid leukemia complicated with synchronous primary solid tumor].
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[Clinical significance of transrectal ultrasound in detecting of rectal cancer margin and deciding of distal surgical incisal edge]
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[Clinicopathological characteristics, MSI and K-ras gene mutations of double primary malignancies associated with colorectal cancer].
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[Correlation between the presence of Kras mutation and the presence of the proteins epiregulin and amphiregulin in colon cancer tissue].
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[Correlation of expression of p120ctn , RhoA and Cdc42 and their significance in non-small cell lung cancer.]
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[Detection of genetic mutations in clinical specimens from cancer patients: comparison of NIRCA and SSCP scanning methods]
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[Detection of K-ras gene mutations in DNA extracted from the plasma of patients with pancreatic cancer]
Neoplasms
[Detection of K-ras mutations in colon cancer by PHA-PHFA (preferential homoduplex formation assay)]
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[Detection of K-ras oncogene activation in human lung cancer and its possible clinical application]
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[Detection of K-ras point mutations in the stool of patients with colorectal tumors]
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[Detection of micrometastases after curative resection for ductal adenocarcinoma of the pancreas]
Neoplasms
[Detection of P53 and K-ras gene mutations in lung cancer with oligonucleotide chip]
Neoplasms
[Detection of point mutation of Kirsten ras oncogene in pancreatic carcinoma by polymerase chain reaction]
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[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
Neoplasms
[Developing a hospital-based high risk scoring model and screening strategy for pancreatic cancer]
Neoplasms
[Diagnosis of papilloma viruses in cervical cancer in 414 women from Wielkopolska region by the immunohistochemical assessment]
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[Effect of blocking of ROCK-1, an effector of small G protein Rho, on the malignant behavior of ovarian tumor cells in vitro]
Neoplasms
[Effect of Cdc42 gene inhibited on proliferation, migration and invasion in human hepatocellular carcinoma cells].
Neoplasms
[Effect of d-limonene, Salvia miltiorrhiza and turmeric derivatives on membrane association of Ras gene product and gap junction intercellular communication]
Neoplasms
[Effect of p38MAPK gene silencing on expression of oncogenes and apoptotic genes induced by PM(2.5) in hepatocytes].
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[Effects of tetrahydrobiopterin on the angiogenesis in hepatocellular carcinoma].
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[EGFR tyrosine kinase inhibitors as a targeted therapy for bronchioloalveolar carcinoma of the lung: a case report of a clinically prompt and intensive response and literature review]
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[Establishment and its biological characteristics of patient-derived lung cancer xenograft models]
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[Evaluation of prognostic factors in gynecological cancer examined by molecular biological study]
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[Evolution of aneuploidy from diploid colorectal carcinoma as revealed by the analyses of ploidy heterogeneity and Ras mutation patterns]
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[Expression and clinical significance of caspase-3,survivin and k-ras in non-small cell lung cancer.]
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[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
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[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
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[Frequency and clinicopathological associations of K-ras mutations in Venezuelan patients with colo-rectal cancer]
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[General rules for the study of pancreatic cancer by molecular biological aspect]
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[Genetic abnormalities of digestive tract adenocarcinomas and correlation with the histologic sequence of their development]
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[Genetic alterations in preneoplastic and neoplastic injuries of the gallbladder]
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[K-ras mutations detection in paraaortic lymph nodes and its prognostic value after the surgical treatment of pancreas cancer]
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[K-ras oncogene in bronchial cancer. Its current prognostic role and long-term therapeutic perspectives]
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[miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells].
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[Molecular-genetic analysis of clonal intratumoral heterogeneity on colorectal adenocarcinomas]
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[Multiple gene alterations involved in the processor of human gastric carcinogenesis]
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[Mutation analysis of K-ras protooncogene in colorectal adenocarcinomas and polyps in Russian patients]
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[Mutational activation of H-ras and K-ras (Codon 12,61) genes in 7,12 dimethylbenz(a)anthracene induced rat ovarian tumors]
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[Mutations in codon 61 in H-ras gene in liver tumors induced by strong and week carcinogens in mice]
Neoplasms
[Pulmonary carcinogenesis susceptibility-associated single-nucleotide polymorphisms in K-ras intron 2 affect the binding of factor Gata-6 but not gene expression]
Neoplasms
[Relationship between EGFR and K-ras mutations and clinicopathological characteristics and response to erlotinib treatment in 301 Chinese patients with non-small cell lung cancer].
Neoplasms
[Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
Neoplasms
[Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]
Neoplasms
[Screening for K-ras mutations in colorectal and lung cancers by using a novel real-time PCR with ADx-K-ras kit and Sanger DNA sequencing].
Neoplasms
[Sensitive detection of K-ras oncogene codon 12 mutations by nested PCR using mismatched primers and selective digestion of non-mutated PCR fragments with restriction enzyme]
Neoplasms
[Serous genital carcinoma : Molecular pathogenesis and the role of tubal fimbria.]
Neoplasms
[Significance of detection of K-ras gene mutations and CA19-9 in serum for diagnosis of pancreatic carcinoma]
Neoplasms
[Specific immune against pancreatic cancer induced by dendritic cells pulsed with mutant K-ras peptide]
Neoplasms
[Studies on association between the ATL and the development of multiple malignant neoplasms--analysis of 1171 cases of hematological malignancies during the past 24 years]
Neoplasms
[Study of 8-OH-dG and its correlation with several cancer related gene in lung cancer tissues]
Neoplasms
[Study of angiogenesis in human colorectal carcinoma and its modulation by p53 and K-ras gene]
Neoplasms
[Study of mesenchymal stem cells transfected with oncogenes differentiate into hepatocellular carcinoma of rats]
Neoplasms
[Study on the mutations of p53 and K-ras gene in the cancer tissues and sputum cells of patients with lung cancer.]
Neoplasms
[The clinical and pathological features, biomarker characteristics and prognosis analysis of lung adenosquamous carcinoma].
Neoplasms
[The distribution of various type of oncogenes products in the tumor tissue of malignant mesothelioma]
Neoplasms
[The effect of antisense H-ras on growth and metastasis of a high metastatic tumor model of human hepatoma in nude mice LCI-D20]
Neoplasms
[The mouse ovarian surface epithelium cells (MOSE) transformation induced by c-myc/K-ras in]
Neoplasms
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
Neoplasms
[The study of correlation between the K-ras genotype and murine susceptibility to chemically induced lung neoplasms]
Neoplasms
[Treatment of metastatic colorectal cancer: an illustration of the changes in the cancer paradigms].
Neoplasms
[Tumor antigens presented to T helper lymphocytes--critical components of the cancer vaccine]
Neoplasms
[Value of fecal and blood adenomatous polyposis coli gene and K-ras gene mutation detection in colorectal neoplasm screening]
Neoplasms by Site
Highly methylated genes in colorectal neoplasia: implications for screening.
Neoplasms, Germ Cell and Embryonal
K-RAS and N-RAS mutations in testicular germ cell tumors.
Neoplasms, Glandular and Epithelial
Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Neoplasms, Glandular and Epithelial
Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
Neoplasms, Squamous Cell
Motility-related proteins as markers for head and neck squamous cell cancer.
Neoplasms, Squamous Cell
Prognostic Significance of Rab27A and Rab27B Expression in Esophageal Squamous Cell Cancer.
Neoplastic Cells, Circulating
A Colorimetric Method for Detection of K-ras Codon 12 Point Mutations in DNA Extracted from Tissue and Peripheral Blood in Pancreatic Disorders.
Neoplastic Cells, Circulating
A fast and convenient new technique to detect the therapeutic target, K-ras mutant, from peripheral blood in non-small cell lung cancer patients.
Neoplastic Cells, Circulating
Detection of ras gene mutations in peripheral blood of carcinoma patients using CD45 immunomagnetic separation and nested mutant allele specific amplification.
Neoplastic Cells, Circulating
Detection of tumor cells in blood using CD45 magnetic cell separation followed by nested mutant allele-specific amplification of p53 and K-ras genes in patients with colorectal cancer.
Neoplastic Cells, Circulating
K-RAS Mutant Gene Found in Pancreatic Juice Activated Chromatin From Peri-ampullary Adenocarcinomas.
Neoplastic Cells, Circulating
K-ras mutational analysis of polyclonal colorectal cancers identifies uniclonal circulating tumor cells.
Neoplastic Cells, Circulating
Portal Venous Blood Circulation Supports Immunosuppressive Environment and Pancreatic Cancer Circulating Tumor Cell Activation.
Neoplastic Cells, Circulating
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
Nephrosis
Fluvastatin Ameliorates Podocyte Injury in Proteinuric Rats via Modulation of Excessive Rho Signaling.
Nephrotic Syndrome
ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.
Nephrotic Syndrome
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Nervous System Diseases
Disruption of the IQSEC2 transcript in a female with X;autosome translocation t(X;20)(p11.2;q11.2) and a phenotype resembling X-linked infantile spasms (ISSX) syndrome.
Nervous System Diseases
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses cell motility.
Neuralgia
Emerging strategies to promote improved functional outcome after peripheral nerve injury.
Neuralgia
Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection.
Neuralgia
microRNA-331-3p attenuates neuropathic pain following spinal cord injury via targeting RAP1A.
Neuralgia
MicroRNA-340-5p relieved chronic constriction injury-induced neuropathic pain by targeting Rap1A in rat model.
Neuralgia
MiR-203 Involves in Neuropathic Pain Development and Represses Rap1a Expression in Nerve Growth Factor Differentiated Neuronal PC12 Cells.
Neuralgia
miR-590-3p Alleviates diabetic peripheral neuropathic pain by targeting RAP1A and suppressing infiltration by the T cells.
Neurilemmoma
Actin-rich protrusions and nonlocalized GTPase activation in Merlin-deficient schwannomas.
Neurilemmoma
Altered adhesive structures and their relation to RhoGTPase activation in merlin-deficient Schwannoma.
Neurilemmoma
Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells.
Neurilemmoma
miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.
Neurilemmoma
PAK kinase regulates Rac GTPase and is a potential target in human schwannomas.
Neurilemmoma
Rearrangements of the intermediate filament GFAP in primary human schwannoma cells.
Neurobehavioral Manifestations
Synaptic proteins in CSF relate to Parkinson's disease stage markers.
Neuroblastoma
Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells.
Neuroblastoma
Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A.
Neuroblastoma
CDC42 expression is altered by dioxin exposure and mediated by multilevel regulations via AhR in human neuroblastoma cells.
Neuroblastoma
Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells.
Neuroblastoma
Cloning of a brain-type isoform of human Rab GDI and its expression in human neuroblastoma cell lines and tumor specimens.
Neuroblastoma
Correction: Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
Neuroblastoma
Effect of let-7c on the PI3K/Akt/FoxO signaling pathway in hepatocellular carcinoma.
Neuroblastoma
Effect of vitamin E succinate and a cAMP-stimulating agent on the expression of c-myc and N-myc and H-ras in murine neuroblastoma cells.
Neuroblastoma
GDNF-induced cell signaling and neurite outgrowths are differentially mediated by GFRalpha1 isoforms.
Neuroblastoma
GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.
Neuroblastoma
Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice.
Neuroblastoma
Guanine Nucleotide Exchange Factors for RhoGTPases: Good Therapeutic Targets for Cancer Therapy?
Neuroblastoma
Heterogeneity in retinoic acid signaling in neuroblastomas: Role of matrix metalloproteinases in retinoic acid-induced differentiation.
Neuroblastoma
Identification of H, K, and N-ras point mutations in stage IB cervical carcinoma.
Neuroblastoma
In contrast to EGFr gene overexpression, H-ras gene expression decreases in human gliomas.
Neuroblastoma
Increased Ras expression and caspase-independent neuroblastoma cell death: possible mechanism of spontaneous neuroblastoma regression.
Neuroblastoma
Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.
Neuroblastoma
Inhibition of farnesyl-protein-transferase in neuroblastoma cells by alpha-hydroxyfarnesylphosphonate.
Neuroblastoma
Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells.
Neuroblastoma
JNK phosphorylation of paxillin, acting through the Rac1 and Cdc42 signaling cascade, mediates neurite extension in N1E-115 cells.
Neuroblastoma
Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers.
Neuroblastoma
MeHg affects the activation of FAK, Src, Rac1 and Cdc42, critical proteins for cell movement in PDGF-stimulated SH-SY5Y neuroblastoma cells.
Neuroblastoma
Metformin impairs Rho GTPase signaling to induce apoptosis in neuroblastoma cells and inhibits growth of tumors in the xenograft mouse model of neuroblastoma.
Neuroblastoma
miR-149 inhibits cell proliferation and enhances chemosensitivity by targeting CDC42 and BCL2 in neuroblastoma.
Neuroblastoma
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.
Neuroblastoma
NEDD9 regulates 3D migratory activity independent of the Rac1 morphology switch in glioma and neuroblastoma.
Neuroblastoma
Neuroblastoma: inhibition of progression (Part II). Basic science in pediatric surgery.
Neuroblastoma
Nonsteroidal anti-inflammatory drugs attenuate amyloid-? protein-induced actin cytoskeletal reorganization through Rho signaling modulation.
Neuroblastoma
NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.
Neuroblastoma
Occurrence of two types of secretory vesicles in the human neuroblastoma SH-SY5Y.
Neuroblastoma
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Neuroblastoma
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells.
Neuroblastoma
Rab15 expression correlates with retinoic acid-induced differentiation of neuroblastoma cells.
Neuroblastoma
Rac GTPase regulation of 3D invasion in neuroblastomas lacking MYCN amplification.
Neuroblastoma
Rac1 and Cdc42 but not RhoA or Rho kinase activities are required for neurite outgrowth induced by the Netrin-1 receptor DCC (deleted in colorectal cancer) in N1E-115 neuroblastoma cells.
Neuroblastoma
Rare frequencey of point mutations for codon 12, 13 and 61 of ras gene in italian neuroblastoma.
Neuroblastoma
Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid.
Neuroblastoma
SIGNAL TRANSDUCTION. Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling.
Neuroblastoma
Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation.
Neuroblastoma
Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.
Neuroblastoma
Stathmin mediates neuroblastoma metastasis in a tubulin-independent manner via RhoA/ROCK signaling and enhanced transendothelial migration.
Neuroblastoma
Stimulation of PrP(C) retrograde transport toward the endoplasmic reticulum increases accumulation of PrP(Sc) in prion-infected cells.
Neuroblastoma
Synthetic Rab3A effector domain peptide stimulates inositol 1,4,5-trisphosphate production in various permeabilized cells.
Neuroblastoma
The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling.
Neuroblastoma
The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus.
Neuroblastoma
Vasoactive intestinal peptide-induced neurite remodeling in human neuroblastoma SH-SY5Y cells implicates the Cdc42 GTPase and is independent of Ras-ERK pathway.
Neurodegenerative Diseases
Allosteric binding sites in Rab11 for potential drug candidates.
Neurodegenerative Diseases
Altered Distribution of RhoA in Alzheimer's Disease and AbetaPP Overexpressing Mice.
Neurodegenerative Diseases
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Neurodegenerative Diseases
Coordination of synaptic vesicle trafficking and turnover by the Rab35 signaling network.
Neurodegenerative Diseases
ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
Neurodegenerative Diseases
Functional enhancement and protection of dopaminergic terminals by RAB3B overexpression.
Neurodegenerative Diseases
Guanine nucleotide induced conformational change of Cdc42 revealed by hydrogen/deuterium exchange mass spectrometry.
Neurodegenerative Diseases
Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.
Neurodegenerative Diseases
Mechanistic Differences of Activation of Rac1P29S and Rac1A159V.
Neurodegenerative Diseases
Overexpression cdc42 attenuates isoflurane-induced neurotoxicity in developmental brain of rats.
Neurodegenerative Diseases
Perspectives of RAS and RHEB GTPase Signaling Pathways in Regenerating Brain Neurons.
Neurodegenerative Diseases
Rab11-mediated recycling endosome role in nervous system development and neurodegenerative diseases.
Neurodegenerative Diseases
RAB21 interacts with TMED10 and modulates its localization and abundance.
Neuroectodermal Tumors, Primitive
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
Neuroectodermal Tumors, Primitive
Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.
Neuroendocrine Tumors
Analysis of K-ras, N-ras, H-ras, and p53 in lung neuroendocrine neoplasms.
Neuroendocrine Tumors
Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.
Neuroendocrine Tumors
Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
Neuroendocrine Tumors
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Neuroendocrine Tumors
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor.
Neurofibroma
Tranilast inhibits the expression of genes related to epithelial-mesenchymal transition and angiogenesis in neurofibromin-deficient cells.
Neurofibroma, Plexiform
Correction: Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Neurofibroma, Plexiform
Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Neurofibromatoses
Characterization of a GTPase-activating protein for the Ras-related Ral protein.
Neurofibromatoses
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
Neurofibromatoses
Correction: Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Neurofibromatoses
Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17.
Neurofibromatoses
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Neurofibromatoses
Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras.
Neurofibromatoses
Infrequent involvement of mutations on neurofibromatosis type 1, H-ras, K-ras and N-ras in urothelial tumors.
Neurofibromatoses
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
Neurofibromatoses
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
Neurofibromatoses
Neurofibromin is required for barrel formation in the mouse somatosensory cortex.
Neurofibromatoses
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia.
Neurofibromatoses
NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos.
Neurofibromatoses
Suppression of oncogenic Ras by mutant neurofibromatosis type 1 genes with single amino acid substitutions.
Neurofibromatoses
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae.
Neurofibromatoses
The guanine triphosphatase (GTPase) activating protein (GAP)-related domain of the neurofibromatosis type 1 gene is not mutated in neural crest-derived sporadic tumours.
Neurofibromatoses
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
Neurofibromatosis 1
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
Neurofibromatosis 1
Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes.
Neurofibromatosis 1
Heterogeneous amino acids in Ras and Rap1A specifying sensitivity to GAP proteins.
Neurofibromatosis 1
Infrequent involvement of mutations on neurofibromatosis type 1, H-ras, K-ras and N-ras in urothelial tumors.
Neurofibromatosis 1
Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension.
Neurofibromatosis 1
Neurofibromin is required for barrel formation in the mouse somatosensory cortex.
Neurofibromatosis 1
Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia.
Neurofibromatosis 1
NF1 tumor suppressor protein and mRNA in skeletal tissues of developing and adult normal mouse and NF1-deficient embryos.
Neurofibromatosis 1
The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae.
Neurofibromatosis 1
The guanine triphosphatase (GTPase) activating protein (GAP)-related domain of the neurofibromatosis type 1 gene is not mutated in neural crest-derived sporadic tumours.
Neurofibromatosis 1
The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
Neurofibromatosis 2
Isolation of mutations in the Drosophila homologues of the human Neurofibromatosis 2 and yeast CDC42 genes using a simple and efficient reverse-genetic method.
Neurofibrosarcoma
Classic Ras Proteins Promote Proliferation and Survival via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells.
Neurofibrosarcoma
Critical role of PTEN for development and progression of nerve sheath tumors in neurofibromatosis type 1.
Neurofibrosarcoma
Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors.
Neurofibrosarcoma
Microarray-based copy number analysis of neurofibromatosis type-1 (NF1)-associated malignant peripheral nerve sheath tumors reveals a role for Rho-GTPase pathway genes in NF1 tumorigenesis.
Neurofibrosarcoma
PTEN dosage is essential for neurofibroma development and malignant transformation.
Neurofibrosarcoma
R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.
Neuroinflammatory Diseases
Recombinant Slit2 attenuates neuroinflammation after surgical brain injury by inhibiting peripheral immune cell infiltration via Robo1-srGAP1 pathway in a rat model.
Neutropenia
Hematologic toxicity assessment in solid tumor patients treated with cetuximab: A pooled analysis of 18 randomized controlled trials.
Neutropenia
Study of oncogenic transformation in ex vivo expanded mesenchymal cells, from paediatric bone marrow.
Nevus
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Nevus
Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma.
Nevus
ras mutations in human melanotic lesions: K-ras activation is a frequent and early event in melanoma development.
Nevus, Epithelioid and Spindle Cell
Analysis of mutations in B-RAF, N-RAS, and H-RAS genes in the differential diagnosis of Spitz nevus and spitzoid melanoma.
Nevus, Epithelioid and Spindle Cell
Genetic similarities between Spitz nevus and Spitzoid melanoma in children.
Niemann-Pick Disease, Type C
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Niemann-Pick Diseases
New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD.
Nijmegen Breakage Syndrome
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Non-alcoholic Fatty Liver Disease
Gene expression profiling reveals key genes and pathways related to the development of non-alcoholic fatty liver disease.
Non-alcoholic Fatty Liver Disease
Integrated Analysis and Identification of Novel Biomarkers in Parkinson's Disease.
Non-alcoholic Fatty Liver Disease
The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease.
Noonan Syndrome
Activating mutations in RRAS underlie a phenotype within the RASopathy spectrum and contribute to leukaemogenesis.
Noonan Syndrome
Clinical report of a brain magnetic resonance imaging finding in Noonan syndrome.
Noonan Syndrome
CP6 Anopthalmia and dysembryoplastic neuroepithelial tumours in a family with Noonan syndrome and a novel PTPN11 mutation.
Noonan Syndrome
Development of Noonan syndrome by deregulation of allosteric SOS autoactivation.
Noonan Syndrome
M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.
Noonan Syndrome
Molecules linked to Ras signaling as therapeutic targets in cardiac pathologies.
Obesity
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay.
Obesity
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
Obesity
RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.
Ocular Hypertension
RhoA GTPase-induced ocular hypertension in a rodent model is associated with increased fibrogenic activity in the trabecular meshwork.
Oculocerebrorenal Syndrome
Lowe syndrome protein OCRL1 interacts with Rac GTPase in the trans-Golgi network.
Oculocerebrorenal Syndrome
Lowe syndrome protein Ocrl1 is translocated to membrane ruffles upon Rac GTPase activation: a new perspective on Lowe syndrome pathophysiology.
Oculocerebrorenal Syndrome
Rab35 GTPase and OCRL phosphatase remodel lipids and F-actin for successful cytokinesis.
Oculocerebrorenal Syndrome
Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Odontogenic Tumors
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
Oligodendroglioma
Combined erbB gene overexpression and decreased H-ras gene expression in human gliomas.
Opisthorchiasis
[Molecular genetic approaches in parasitology (in case of opisthorchiasis)]
Optic Nerve Injuries
Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma.
Optic Nerve Injuries
Enhanced survival and regeneration of axotomized retinal neurons by repeated delivery of cell-permeable C3-like Rho antagonists.
Osteoarthritis
Cdc42 Is Essential for Both Articular Cartilage Degeneration and Subchondral Bone Deterioration in Experimental Osteoarthritis.
Osteoarthritis
Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes.
Osteoarthritis
Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy.
Osteonecrosis
[Expression of Ras-Associated Protein 1 in the Vascular Endothelium of Bone Tissue with Non-Traumatic Osteonecrosis of Femoral Head].
Osteoporosis
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Osteoporosis
Involvement of miR-337 in high glucose-suppressed osteogenic differentiation in bone marrow mesenchymal stem cells via negative regulation of Rap1A.
Osteosarcoma
Analyzing time-series microarray data reveals key genes in spinal cord injury.
Osteosarcoma
Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
Osteosarcoma
Clinicopathologic implications of MDM2, p53 and K-ras gene alterations in osteosarcomas: MDM2 amplification and p53 mutations found in progressive tumors.
Osteosarcoma
Daphnetin inhibits invasion and migration of LM8 murine osteosarcoma cells by decreasing RhoA and Cdc42 expression.
Osteosarcoma
Driven to Death: Inhibition of Farnesylation Increases Ras Activity in Osteosarcoma and Promotes Growth Arrest and Cell Death.
Osteosarcoma
Erratum: Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.
Osteosarcoma
Ezrin-related Phosphoinositide pathway modifies RhoA and Rac1 in human osteosarcoma cell lines.
Osteosarcoma
Human herpesvirus 6A ts suppresses both transformation by H-ras and transcription by the H-ras and human immunodeficiency virus type 1 promoters.
Osteosarcoma
Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells.
Osteosarcoma
Identification of biomarkers associated with the recurrence of osteosarcoma using ceRNA regulatory network analysis.
Osteosarcoma
Involvement of small G protein RhoB in the regulation of proliferation, adhesion and migration by dexamethasone in osteoblastic cells.
Osteosarcoma
LINC00665 Facilitates the Malignant Processes of Osteosarcoma by Increasing the RAP1B Expression via Sponging miR-708 and miR-142-5p.
Osteosarcoma
MicroRNA-16 suppressed the invasion and migration of osteosarcoma by directly inhibiting RAB23.
Osteosarcoma
MicroRNA-665 suppressed the invasion and metastasis of osteosarcoma by directly inhibiting RAB23.
Osteosarcoma
MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively.
Osteosarcoma
miR-29a inhibits adhesion, migration, and invasion of osteosarcoma cells by suppressing CDC42.
Osteosarcoma
Molecular analysis of p53, MDM2 and H-ras genes in low-grade central osteosarcoma.
Osteosarcoma
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years.
Osteosarcoma
PI3K? isoform-dependent activation of RhoA regulates Wnt5a-induced osteosarcoma cell migration.
Osteosarcoma
Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells.
Osteosarcoma
Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF-?B, c-Fos and NFATc1 transcription factors.
Osteosarcoma
The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis.
Ovarian Cysts
Expression of motility-related molecule Cdc42 in endometrial tissue in women with adenomyosis and ovarian endometriomata.
Ovarian Neoplasms
A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.
Ovarian Neoplasms
Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
Ovarian Neoplasms
Activated protein C upregulates ovarian cancer cell migration and promotes unclottability of the cancer cell microenvironment.
Ovarian Neoplasms
BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells.
Ovarian Neoplasms
Compressive Stimulation Enhances Ovarian Cancer Proliferation, Invasion, Chemoresistance, and Mechanotransduction via CDC42 in a 3D Bioreactor.
Ovarian Neoplasms
Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes.
Ovarian Neoplasms
Cucurbit [7] uril encapsulated cisplatin overcomes resistance to cisplatin induced by Rab25 overexpression in an intraperitoneal ovarian cancer model.
Ovarian Neoplasms
CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression.
Ovarian Neoplasms
Cytokinesis failure due to derailed integrin traffic induces aneuploidy and oncogenic transformation in vitro and in vivo.
Ovarian Neoplasms
Detection and clinical correlations of ras gene mutations in human ovarian tumors.
Ovarian Neoplasms
Downregulation of Rab23 inhibits proliferation, invasion, and metastasis of human ovarian cancer.
Ovarian Neoplasms
Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer.
Ovarian Neoplasms
FSH receptor binding inhibitor depresses carcinogenesis of ovarian cancer via decreasing levels of K-Ras, c-Myc and FSHR.
Ovarian Neoplasms
FSH receptor binding inhibitor impacts K-Ras and c-Myc of ovarian cancer and signal pathway.
Ovarian Neoplasms
Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B.
Ovarian Neoplasms
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.
Ovarian Neoplasms
Hypoxia-induced exosomes contribute to a more aggressive and chemoresistant ovarian cancer phenotype: a novel mechanism linking STAT3/Rab proteins.
Ovarian Neoplasms
Hypoxia-inducible factor 1 alpha is required for the tumourigenic and aggressive phenotype associated with Rab25 expression in ovarian cancer.
Ovarian Neoplasms
In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer.
Ovarian Neoplasms
K-ras alterations in Danish ovarian tumour patients. From the Danish "Malova" Ovarian Cancer study.
Ovarian Neoplasms
K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases.
Ovarian Neoplasms
lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer.
Ovarian Neoplasms
Long noncoding RNA UCA1 enhances sensitivity to oncolytic vaccinia virus by sponging miR-18a/miR-182 and modulating the Cdc42/filopodia axis in colorectal cancer.
Ovarian Neoplasms
Low-dose glucocorticoids suppresses ovarian tumor growth and metastasis in an immunocompetent syngeneic mouse model.
Ovarian Neoplasms
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway.
Ovarian Neoplasms
Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review).
Ovarian Neoplasms
MCAM is a novel metastasis marker and regulates spreading, apoptosis and invasion of ovarian cancer cells.
Ovarian Neoplasms
MicroRNA-134-3p is a novel potential inhibitor of human ovarian cancer stem cells by targeting RAB27A.
Ovarian Neoplasms
Ovarian adenocarcinomas in the laying hen and women share similar alterations in p53, ras, and HER-2/neu.
Ovarian Neoplasms
Overexpression of Rab27B is correlated with distant metastasis and poor prognosis in ovarian cancer.
Ovarian Neoplasms
R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
Ovarian Neoplasms
Rab23 promotes the cisplatin resistance of ovarian cancer via the Shh-Gli-ABCG2 signaling pathway.
Ovarian Neoplasms
Rap1A promotes ovarian cancer metastasis via activation of ERK/p38 and notch signaling.
Ovarian Neoplasms
RCC2, a regulator of the RalA signaling pathway, is identified as a novel therapeutic target in cisplatin-resistant ovarian cancer.
Ovarian Neoplasms
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
Ovarian Neoplasms
RHPN1?AS1 promotes ovarian carcinogenesis by sponging miR?6884?5p thus releasing TOP2A mRNA.
Ovarian Neoplasms
Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer.
Ovarian Neoplasms
Silencing of H-ras gene expression by retrovirus-mediated siRNA decreases transformation efficiency and tumorgrowth in a model of human ovarian cancer.
Ovarian Neoplasms
Simvastatin is a potential candidate drug in ovarian clear cell carcinomas.
Ovarian Neoplasms
SKP2/P27Kip1 pathway is associated with Advanced Ovarian Cancer in Saudi Patients.
Ovarian Neoplasms
The R-enantiomer of ketorolac reduces ovarian cancer tumor burden in vivo.
Ovarian Neoplasms
The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells.
Ovarian Neoplasms
Use of ras-transformed human ovarian surface epithelial cells as a model for studying ovarian cancer.
Ovarian Neoplasms
[Lysophosphatidic acid (LPA) stimulates invasion and metastatic colonization of ovarian cancer cells through Rac activation].
Ovarian Neoplasms
[The mouse ovarian surface epithelium cells (MOSE) transformation induced by c-myc/K-ras in]
Paget Disease, Extramammary
PI3K, Rac1 and pPAK1 are overexpressed in extramammary Paget's disease.
Pancreatic Cyst
A comparative analysis of K-ras mutation and carcinoembryonic antigen in pancreatic cyst fluid.
Pancreatic Cyst
High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions.
Pancreatic Cyst
Pancreatic cyst fluid DNA analysis in evaluating pancreatic cysts: a report of the PANDA study.
Pancreatic Cyst
The role of molecular analysis in the diagnosis and surveillance of pancreatic cystic neoplasms.
Pancreatic Cyst
The role of pancreatic cyst fluid molecular analysis in predicting cyst pathology.
Pancreatic Diseases
Analysis of K-ras codon 12 point mutations using duodenal lavage fluid for diagnosis of pancreatic carcinoma.
Pancreatic Diseases
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease.
Pancreatic Diseases
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Pancreatic Diseases
Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer.
Pancreatic Diseases
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Pancreatic Diseases
Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
Pancreatic Diseases
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Pancreatic Diseases
Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Pancreatic Diseases
Diagnosis of pancreatic cancer by detecting telomerase activity in pancreatic juice: comparison with K-ras mutations.
Pancreatic Diseases
Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
Pancreatic Diseases
Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer.
Pancreatic Diseases
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
Pancreatic Diseases
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Pancreatic Diseases
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
Pancreatic Diseases
Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients.
Pancreatic Diseases
Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis.
Pancreatic Diseases
Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Pancreatic Diseases
Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer.
Pancreatic Diseases
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
Pancreatic Diseases
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
Pancreatic Intraductal Neoplasms
Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract.
Pancreatic Neoplasms
4-Hydroxytamoxifen induces autophagic death through K-Ras degradation.
Pancreatic Neoplasms
?-catenin-activated autocrine PDGF/Src signaling is a therapeutic target in pancreatic cancer.
Pancreatic Neoplasms
A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice.
Pancreatic Neoplasms
A chronocoulometric LNA sensor for amplified detection of K-ras mutation based on site-specific DNA cleavage of restriction endonuclease.
Pancreatic Neoplasms
A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer.
Pancreatic Neoplasms
A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival.
Pancreatic Neoplasms
A highly sensitive method for K-ras mutation detection is useful in diagnosis of gastrointestinal cancer.
Pancreatic Neoplasms
A homologous promoterless K-ras cDNA targeting endogenous K-ras expression inhibits human pancreatic cancer cell growth in vitro and in vivo.
Pancreatic Neoplasms
A Macropinocytosis-Intensifying Albumin Domain-Based scFv Antibody and Its Conjugate Directed against K-Ras Mutant Pancreatic Cancer.
Pancreatic Neoplasms
A meta-analysis of the diagnostic value of detecting K-ras mutation in pancreatic juice as a molecular marker for pancreatic cancer.
Pancreatic Neoplasms
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Pancreatic Neoplasms
A novel strategy for inhibiting growth of human pancreatic cancer cells by blocking cyclin-dependent kinase activity.
Pancreatic Neoplasms
A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.
Pancreatic Neoplasms
A recombinantly tailored ?-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer.
Pancreatic Neoplasms
A triple combination of atorvastatin, celecoxib and tipifarnib strongly inhibits pancreatic cancer cells and xenograft pancreatic tumors.
Pancreatic Neoplasms
Absence of K-ras mutations in the pancreatic parenchyma of patients with chronic pancreatitis.
Pancreatic Neoplasms
Accomplishments in 2007 in biologic markers for gastrointestinal cancers.
Pancreatic Neoplasms
Activated K-ras and INK4a/Arf deficiency cooperate during the development of pancreatic cancer by activation of Notch and NF-?B signaling pathways.
Pancreatic Neoplasms
Activated K-Ras and INK4a/Arf deficiency promote aggressiveness of pancreatic cancer by induction of EMT consistent with cancer stem cell phenotype.
Pancreatic Neoplasms
Adenocarcinoma of the pancreas: detection of occult metastases in regional lymph nodes by a polymerase chain reaction-based assay.
Pancreatic Neoplasms
Adenovirus-mediated anti-K-ras ribozyme induces apoptosis and growth suppression of human pancreatic carcinoma.
Pancreatic Neoplasms
Adjusting serum concentrations of organochlorine compounds by lipids and symptoms: a causal framework for the association with K-ras mutations in pancreatic cancer.
Pancreatic Neoplasms
Advances in Molecular Pathology and Treatment of Periampullary Cancers.
Pancreatic Neoplasms
An adenosine-mediated signaling pathway suppresses prenylation of the GTPase Rap1B and promotes cell scattering.
Pancreatic Neoplasms
An anti-K-ras ribozyme suppresses oncogene expression and cell growth of human pancreatic cancer.
Pancreatic Neoplasms
An Epidemiological Overview of Environmental and Genetic Risk Factors of Pancreatic Cancer.
Pancreatic Neoplasms
An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine.
Pancreatic Neoplasms
Analysis of K-ras gene mutations in human pancreatic cancer cell lines and in bile samples from patients with pancreatic and biliary cancers.
Pancreatic Neoplasms
Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours.
Pancreatic Neoplasms
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.
Pancreatic Neoplasms
Analysis of Kras gene from induced pancreatic cancer rats administered with Momordicacharantia and Ocimumbasilicum leaf extracts.
Pancreatic Neoplasms
Anti-proliferative and proapoptotic effects of benzyl isothiocyanate on human pancreatic cancer cells is linked to death receptor activation and RasGAP/Rac1 down-modulation.
Pancreatic Neoplasms
Antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines.
Pancreatic Neoplasms
Antisense therapy specific to mutated K-ras gene in hamster pancreatic cancer model. Can it inhibit the growth of 5-FU and MMC-resistant metastatic and remetastatic cell lines?
Pancreatic Neoplasms
Antitumor activity of erlotinib in combination with gemcitabine in in vitro and in vivo models of KRAS-mutated pancreatic cancers.
Pancreatic Neoplasms
Aphanin, a triterpenoid from Amoora rohituka inhibits K-Ras mutant activity and STAT3 in pancreatic carcinoma cells.
Pancreatic Neoplasms
ARF6, induced by mutant Kras, promotes proliferation and Warburg effect in pancreatic cancer.
Pancreatic Neoplasms
ARHGEF15 overexpression worsens the prognosis in patients with pancreatic ductal adenocarcinoma through enhancing the motility and proliferative activity of the cancer cells.
Pancreatic Neoplasms
Assembling Mn:ZnSe quantum dots-siRNA nanoplexes for gene silencing in tumor cells.
Pancreatic Neoplasms
Association between coffee drinking and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Pancreatic Neoplasms
BART inhibits pancreatic cancer cell invasion by inhibiting ARL2-mediated RhoA inactivation.
Pancreatic Neoplasms
Beyond the Genomic Mutation: Rethinking the Molecular Biomarkers of K-RAS Dependency in Pancreatic Cancers.
Pancreatic Neoplasms
Biliopancreatic malignancy: screening the at risk patient with molecular markers.
Pancreatic Neoplasms
Biodegradable nanoparticle-mediated K-ras down regulation for pancreatic cancer gene therapy.
Pancreatic Neoplasms
Blockage of intermediate-conductance Ca2+-activated K+ channels inhibit human pancreatic cancer cell growth in vitro.
Pancreatic Neoplasms
CDDO-Me: A Novel Synthetic Triterpenoid for the Treatment of Pancreatic Cancer.
Pancreatic Neoplasms
Cetuximab delivery and antitumor effects are enhanced by mild hyperthermia in a xenograft mouse model of pancreatic cancer.
Pancreatic Neoplasms
Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines.
Pancreatic Neoplasms
Cigarette smoking and K-ras mutations in pancreas, lung and colorectal adenocarcinomas: Etiopathogenic similarities, differences and paradoxes.
Pancreatic Neoplasms
Clear cell carcinoma of the pancreas: an adenocarcinoma with ductal phenotype.
Pancreatic Neoplasms
Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.
Pancreatic Neoplasms
Clinical validity of detecting K-ras mutations for the diagnosis of exocrine pancreatic cancer: a prospective study in a clinically-relevant spectrum of patients.
Pancreatic Neoplasms
Clinical value of K-ras codon 12 analysis and endobiliary brush cytology for the diagnosis of malignant extrahepatic bile duct stenosis.
Pancreatic Neoplasms
Coffee, K-ras mutations and pancreatic cancer: a heterogeneous aetiology or an artefact?
Pancreatic Neoplasms
Coffee, pancreatic cancer, and K-ras mutations: updating the research agenda.
Pancreatic Neoplasms
Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status.
Pancreatic Neoplasms
Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.
Pancreatic Neoplasms
Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1? pathway to predict survival in resectable pancreatic cancer.
Pancreatic Neoplasms
Common occurrence of multiple K-RAS mutations in pancreatic cancers with associated precursor lesions and in biliary cancers.
Pancreatic Neoplasms
Comparative analysis of mutations in the p53 and K-ras genes in pancreatic cancer.
Pancreatic Neoplasms
Comparing the diagnostic accuracy of five common tumour biomarkers and CA19-9 for pancreatic cancer: a protocol for a network meta-analysis of diagnostic test accuracy.
Pancreatic Neoplasms
Comparison of K-ras point mutations at codon 12 and p21 expression in pancreatic cancer between Japanese and Chinese patients.
Pancreatic Neoplasms
Contribution of epithelial-to-mesenchymal transition and cancer stem cells to pancreatic cancer progression.
Pancreatic Neoplasms
Correction: Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to ?-irradiation.
Pancreatic Neoplasms
Correlation Between RAB27B and p53 Expression and Overall Survival in Pancreatic Cancer.
Pancreatic Neoplasms
Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells.
Pancreatic Neoplasms
Cyclin Dependent Kinase 5 is amplified and over-expressed in pancreatic cancer and activated by mutant K-Ras.
Pancreatic Neoplasms
Decreased expression of DAB2IP in pancreatic cancer with wild-type KRAS.
Pancreatic Neoplasms
Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer.
Pancreatic Neoplasms
Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer.
Pancreatic Neoplasms
Detection of K-ras gene mutation by liquid biopsy in patients with pancreatic cancer.
Pancreatic Neoplasms
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Pancreatic Neoplasms
Detection of K-ras gene mutations in feces by magnetic nanoprobe in patients with pancreatic cancer: A preliminary study.
Pancreatic Neoplasms
Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer.
Pancreatic Neoplasms
Detection of K-ras mutations in pancreatic and hepatic neoplasms by non-isotopic mismatched polymerase chain reaction.
Pancreatic Neoplasms
Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients.
Pancreatic Neoplasms
Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer.
Pancreatic Neoplasms
Detection of K-ras point mutation at codon 12 in pure pancreatic juice collected 3 years and 6 months before the clinical diagnosis of pancreatic cancer.
Pancreatic Neoplasms
Detection of K-ras point mutation by enriched PCR-colorimetric plate assay.
Pancreatic Neoplasms
Detection of K-ras point mutations at codon 12 in pancreatic juice for the diagnosis of pancreatic cancer by hybridization protection assay: a simple method for the determination of the types of point mutation.
Pancreatic Neoplasms
Detection of K-ras point mutations at codon 12 in pure pancreatic juice for the diagnosis of pancreatic cancer by PCR-RFLP analysis.
Pancreatic Neoplasms
Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: comparison with K-ras mutation.
Pancreatic Neoplasms
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Pancreatic Neoplasms
Detection of point mutations in K-ras gene at codon 12 in bile from percutaneous transhepatic choledochal drainage tubes for diagnosis of biliary strictures.
Pancreatic Neoplasms
Detection of ras gene mutations in perioperative peripheral blood with pancreatic adenocarcinoma.
Pancreatic Neoplasms
Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Pancreatic Neoplasms
Diagnosis of pancreatic cancer by detecting telomerase activity in pancreatic juice: comparison with K-ras mutations.
Pancreatic Neoplasms
Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Pancreatic Neoplasms
Diagnosis of pancreatico-biliary malignancy: detection of gene mutations in plasma and stool.
Pancreatic Neoplasms
Diagnostic utility of K-ras mutations in fine-needle aspirates of pancreatic masses.
Pancreatic Neoplasms
Diagnostic value of K-ras mutations in serum of pancreatic cancer patients.
Pancreatic Neoplasms
Dietary Garcinol Arrests Pancreatic Cancer in p53 and K-ras Conditional Mutant Mouse Model.
Pancreatic Neoplasms
Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA.
Pancreatic Neoplasms
Differential high-resolution melting analysis for the detection of K-ras codons 12 and 13 mutations in pancreatic cancer.
Pancreatic Neoplasms
Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition.
Pancreatic Neoplasms
Disruption of actin filaments and suppression of pancreatic cancer cell viability and migration following treatment with polyisoprenylated cysteinyl amides.
Pancreatic Neoplasms
DNA adducts, genetic polymorphisms, and K-ras mutation in human pancreatic cancer.
Pancreatic Neoplasms
Doc-2/hDab2 expression is up-regulated in primary pancreatic cancer but reduced in metastasis.
Pancreatic Neoplasms
Does detection of K-ras mutations in pancreatic juice influence clinical decision making?
Pancreatic Neoplasms
Down-regulation of the nuclear factor-kappaB by lidamycin in association with inducing apoptosis in human pancreatic cancer cells and inhibiting xenograft growth.
Pancreatic Neoplasms
Downregulation of PAR-4, a pro-apoptotic gene, in pancreatic tumors harboring K-ras mutation.
Pancreatic Neoplasms
Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer.
Pancreatic Neoplasms
Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice.
Pancreatic Neoplasms
Effective treatment of pancreatic cancer xenografts with a conditionally replicating virus derived from type 2 herpes simplex virus.
Pancreatic Neoplasms
Effects of antisense oligonucleotides targeting k-ras expression in pancreatic-cancer cell-lines.
Pancreatic Neoplasms
Effects of Rab27A and Rab27B on Invasion, Proliferation, Apoptosis, and Chemoresistance in Human Pancreatic Cancer Cells.
Pancreatic Neoplasms
Effects of the antitumor agent perillyl alcohol on H-Ras vs. K-Ras farnesylation and signal transduction in pancreatic cells.
Pancreatic Neoplasms
Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides.
Pancreatic Neoplasms
Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells.
Pancreatic Neoplasms
Epigenetics and pancreatic cancer: pathophysiology and novel treatment aspects.
Pancreatic Neoplasms
Establishment and characterization of a new human pancreatic adenocarcinoma cell line with high metastatic potential to the lung.
Pancreatic Neoplasms
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Pancreatic Neoplasms
Evaluation of K-ras and p53 expression in pancreatic adenocarcinoma using the cancer genome atlas.
Pancreatic Neoplasms
Evaluation of the diagnostic value of serum tumor markers, and fecal k-ras and p53 gene mutations for pancreatic cancer.
Pancreatic Neoplasms
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Pancreatic Neoplasms
Expression profiles of pancreatic cancer cell lines infected with antisense K-ras-expressing adenoviral vector.
Pancreatic Neoplasms
Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system.
Pancreatic Neoplasms
FAK and interacting proteins as therapeutic targets in pancreatic cancer.
Pancreatic Neoplasms
Farnesyltransferase inhibitor (L-744,832) restores TGF-beta type II receptor expression and enhances radiation sensitivity in K-ras mutant pancreatic cancer cell line MIA PaCa-2.
Pancreatic Neoplasms
Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
Pancreatic Neoplasms
Food and nutrient intakes and K-ras mutations in exocrine pancreatic cancer.
Pancreatic Neoplasms
Frequent and Significant K-ras Mutation in the Pancreas, the Bile Duct, and the Gallbladder in Autoimmune Pancreatitis.
Pancreatic Neoplasms
Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases.
Pancreatic Neoplasms
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Pancreatic Neoplasms
Functionalized Graphene@Gold Nanostar/Lipid for Pancreatic Cancer Gene and Photothermal Synergistic Therapy under Photoacoustic/Photothermal Imaging Dual-Modal Guidance.
Pancreatic Neoplasms
Gene expression profiling of adenosine triphosphate-binding cassette transporters in response to K-ras activation and hypoxia in human pancreatic cancer cell cultures.
Pancreatic Neoplasms
Generalizing molecular results arising from incomplete biological samples: expected bias and unexpected findings.
Pancreatic Neoplasms
Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations.
Pancreatic Neoplasms
Genetic Alterations of K-ras, p53, c-erbB-2, and DPC4 in Pancreatic Ductal Adenocarcinoma and Their Correlation With Patient Survival.
Pancreatic Neoplasms
Genetic diagnosis of pancreatic cancer using specimens obtained by EUS-FNA.
Pancreatic Neoplasms
Genomic instability and histone H3 phosphorylation induction by the Ras-mitogen activated protein kinase pathway in pancreatic cancer cells.
Pancreatic Neoplasms
Graphene-Assisted Electrochemical Sensor for Detection of Pancreatic Cancer Markers.
Pancreatic Neoplasms
Growth inhibition of human pancreatic cancer cell lines by anti-sense oligonucleotides specific to mutated K-ras genes.
Pancreatic Neoplasms
Hammerhead ribozyme specifically inhibits mutant K-ras mRNA of human pancreatic cancer cells.
Pancreatic Neoplasms
Hdm2 is regulated by K-Ras and mediates p53-independent functions in pancreatic cancer cells.
Pancreatic Neoplasms
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis.
Pancreatic Neoplasms
High expression of RAB27A and TP53 in pancreatic cancer predicts poor survival.
Pancreatic Neoplasms
High expression of RAB38 promotes malignant progression of pancreatic cancer.
Pancreatic Neoplasms
High Levels of Cell-Free Circulating Nucleic Acids in Pancreatic Cancer are Associated With Vascular Encasement, Metastasis and Poor Survival.
Pancreatic Neoplasms
High proportion of mutant K-ras gene in pancreatic juice of patients with pancreatic cystic lesions.
Pancreatic Neoplasms
High yields of K-ras mutations in intraductal papillary mucinous tumors and invasive adenocarcinomas induced by N-nitroso(2-hydroxypropyl)(2-oxopropyl)amine in the pancreas of female Syrian hamsters.
Pancreatic Neoplasms
How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization.
Pancreatic Neoplasms
Hydrogel-microsphere-enhanced surface plasmon resonance for the detection of a K-ras point mutation employing peptide nucleic acid.
Pancreatic Neoplasms
Hyperstable U1snRNA complementary to the K-ras transcripts induces cell death in pancreatic cancer cells.
Pancreatic Neoplasms
Identification of effective siRNA against K-ras in human pancreatic cancer cell line MiaPaCa-2 by siRNA expression cassette.
Pancreatic Neoplasms
Identification of genes showing differential expression in antisense K-ras-transduced pancreatic cancer cells with suppressed tumorigenicity.
Pancreatic Neoplasms
Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer.
Pancreatic Neoplasms
Identification of K-ras oncogene mutations in the pure pancreatic juice of patients with ductal pancreatic cancers.
Pancreatic Neoplasms
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Pancreatic Neoplasms
In-silico design of peptide inhibitors of K-Ras target in cancer disease.
Pancreatic Neoplasms
Inactivation of Ink4a/Arf leads to deregulated expression of miRNAs in K-Ras transgenic mouse model of pancreatic cancer.
Pancreatic Neoplasms
Inactivation of Rab23 inhibits the invasion and motility of pancreatic duct adenocarcinoma.
Pancreatic Neoplasms
Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells.
Pancreatic Neoplasms
Increased telomerase activities in human pancreatic duct adenocarcinomas.
Pancreatic Neoplasms
Induction of CTLs by DCs pulsed with K-ras mutant peptide on the surface of nanoparticles in the treatment of pancreatic cancer.
Pancreatic Neoplasms
Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad.mda-7-induced apoptosis.
Pancreatic Neoplasms
Inhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
Pancreatic Neoplasms
Inhibition of growth and invasive activity of human pancreatic cancer cells by a farnesyltransferase inhibitor, manumycin.
Pancreatic Neoplasms
Inhibition of human pancreatic cancer cell (MIA PaCa-2) growth by cholera toxin and 8-chloro-cAMP in vitro.
Pancreatic Neoplasms
Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility.
Pancreatic Neoplasms
Inhibition of RAC1 GTPase sensitizes pancreatic cancer cells to ?-irradiation.
Pancreatic Neoplasms
Integrin ?1 promotes gemcitabine resistance in pancreatic cancer through Cdc42 activation of PI3K p110? signaling.
Pancreatic Neoplasms
Interferon-alpha and antisense K-ras RNA combination gene therapy against pancreatic cancer.
Pancreatic Neoplasms
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42.
Pancreatic Neoplasms
Intradermal ras peptide vaccination with granulocyte-macrophage colony-stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma.
Pancreatic Neoplasms
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Pancreatic Neoplasms
Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity.
Pancreatic Neoplasms
Invasive ductal adenocarcinoma of the remnant pancreatic body 9 years after resection of an intraductal papillary-mucinous carcinoma of the pancreatic head: a case report and comparison of DNA sequence in K-ras gene mutation.
Pancreatic Neoplasms
Involvement of oncogenic K-ras on cell migration stimulated by lysophosphatidic acid receptor-2 in pancreatic cancer cells.
Pancreatic Neoplasms
IQGAP1 selectively interacts with K-Ras but not with H-Ras and modulates K-Ras function.
Pancreatic Neoplasms
Isolation of a chemical inhibitor against K-Ras-induced p53 suppression through natural compound screening.
Pancreatic Neoplasms
Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells.
Pancreatic Neoplasms
K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions.
Pancreatic Neoplasms
K-ras and p53 in pancreatic cancer: association with medical history, histopathology, and environmental exposures in a population-based study.
Pancreatic Neoplasms
K-ras gene mutations in the diagnosis of fine-needle aspirates of pancreatic masses: prospective study using two techniques with different detection limits.
Pancreatic Neoplasms
K-RAS Mutant Pancreatic Tumors Show Higher Sensitivity to MEK than to PI3K Inhibition In Vivo.
Pancreatic Neoplasms
K-ras mutation and p16 and preproenkephalin promoter hypermethylation in plasma DNA of pancreatic cancer patients: in relation to cigarette smoking.
Pancreatic Neoplasms
K-Ras mutation detection in liquid biopsy and tumor tissue as prognostic biomarker in patients with pancreatic cancer: a systematic review with meta-analysis.
Pancreatic Neoplasms
K-Ras mutation in liquid biopsy and tumor tissue correlation in patients with pancreatic cancer.
Pancreatic Neoplasms
K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review.
Pancreatic Neoplasms
K-ras mutational status in cytohistological tissue as a molecular marker for the diagnosis of pancreatic cancer: a systematic review and meta-analysis.
Pancreatic Neoplasms
K-ras mutational status predicts poor prognosis in unresectable pancreatic cancer.
Pancreatic Neoplasms
K-ras mutations and allelic loss at 5q and 18q in the development of human pancreatic cancers.
Pancreatic Neoplasms
K-ras Mutations in the Plasma Correspond to Computed Tomographic Findings in Patients With Pancreatic Cancer.
Pancreatic Neoplasms
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Pancreatic Neoplasms
K-ras oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment.
Pancreatic Neoplasms
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways.
Pancreatic Neoplasms
K-Ras Promotes Tumorigenicity through Suppression of Non-canonical Wnt Signaling.
Pancreatic Neoplasms
K-Ras-driven pancreatic cancer mouse model for anticancer inhibitor analyses.
Pancreatic Neoplasms
K-Ras-independent effects of the farnesyl transferase inhibitor L-744,832 on cyclin B1/Cdc2 kinase activity, G2/M cell cycle progression and apoptosis in human pancreatic ductal adenocarcinoma cells.
Pancreatic Neoplasms
Lack of elevated MAP kinase (Erk) activity in pancreatic carcinomas despite oncogenic K-ras expression.
Pancreatic Neoplasms
Lifetime history of tobacco consumption and K-ras mutations in exocrine pancreatic cancer.
Pancreatic Neoplasms
Lin28-let7 modulates radiosensitivity of human cancer cells with activation of K-Ras.
Pancreatic Neoplasms
Liposome-mediated in vivo gene transfer of antisense K-ras construct inhibits pancreatic tumor dissemination in the murine peritoneal cavity.
Pancreatic Neoplasms
Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression.
Pancreatic Neoplasms
Long-term follow-up of chronic pancreatitis patients with K-ras mutation in the pancreatic juice.
Pancreatic Neoplasms
Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice.
Pancreatic Neoplasms
Long-term follow-up of patients with resected pancreatic cancer following vaccination against mutant K-ras.
Pancreatic Neoplasms
Lovastatin inhibits pancreatic cancer growth regardless of RAS mutation.
Pancreatic Neoplasms
Lovastatin inhibits proliferation of pancreatic cancer cell lines with mutant as well as with wild-type K-ras oncogene but has different effects on protein phosphorylation and induction of apoptosis.
Pancreatic Neoplasms
Low correspondence between K-ras mutations in pancreatic cancer tissue and detection of K-ras mutations in circulating DNA.
Pancreatic Neoplasms
ME-PCR for the identification of mutated K-ras in serum and bile of pancreatic cancer patients: an unsatisfactory technique for clinical applications.
Pancreatic Neoplasms
Metabolic profiling of gemcitabine- and paclitaxel-treated immortalized human pancreatic cell lines with K-RAS
Pancreatic Neoplasms
Metabolic regulation of EGFR effector and feedback signaling in pancreatic cancer cells requires K-Ras.
Pancreatic Neoplasms
Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer.
Pancreatic Neoplasms
MicroRNA regulation of K-Ras in pancreatic cancer and opportunities for therapeutic intervention.
Pancreatic Neoplasms
miR-137 Modulates a Tumor Suppressor Network-Inducing Senescence in Pancreatic Cancer Cells.
Pancreatic Neoplasms
miR-142-5p regulates pancreatic cancer cell proliferation and apoptosis by regulation of RAP1A.
Pancreatic Neoplasms
miR?448 targets Rab2B and is pivotal in the suppression of pancreatic cancer.
Pancreatic Neoplasms
Modified radiosensitivity of pancreatic cancer xenografts by farnesyl protein transferase inhibitor and MEK inhibitor.
Pancreatic Neoplasms
Molecular alterations associated with improved survival in pancreatic cancer patients treated with radiation or chemotherapy.
Pancreatic Neoplasms
Molecular beacon imaging of tumor marker gene expression in pancreatic cancer cells.
Pancreatic Neoplasms
Molecular biology of pancreatic cancer: potential clinical implications.
Pancreatic Neoplasms
Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective.
Pancreatic Neoplasms
Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy.
Pancreatic Neoplasms
Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients.
Pancreatic Neoplasms
Molecular diagnosis of exocrine pancreatic cancer using a percutaneous technique.
Pancreatic Neoplasms
Molecular markers for diagnostic cytology of neoplasms in the head region of the pancreas: mutation of K-ras and overexpression of the p53 protein product.
Pancreatic Neoplasms
Molecular pathogenesis of pancreatic adenocarcinoma: Potential clinical implications.
Pancreatic Neoplasms
Molecular pathogenesis of pancreatic cancer and clinical perspectives.
Pancreatic Neoplasms
Molecular-based and alternative therapies for pancreatic cancer: looking "out of the box".
Pancreatic Neoplasms
Multiplexed Real-Time NMR GTPase Assay for Simultaneous Monitoring of Multiple Guanine Nucleotide Exchange Factor Activities from Human Cancer Cells and Organoids.
Pancreatic Neoplasms
Mutant K-Ras increases GSK-3? gene expression via an ETS-p300 transcriptional complex in pancreatic cancer.
Pancreatic Neoplasms
Mutant K-RAS Promotes Invasion and Metastasis in Pancreatic Cancer Through GTPase Signaling Pathways.
Pancreatic Neoplasms
Mutated K-ras activates CDK8 to stimulate the epithelial-to-mesenchymal transition in pancreatic cancer in part via the Wnt/?-catenin signaling pathway.
Pancreatic Neoplasms
Mutation Status of K-ras, p53 and Allelic Losses at 9p and 18q Are Not Prognostic Markers in Patients with Pancreatic Cancer.
Pancreatic Neoplasms
Mutations in K-Ras linked to levels of osteoprotegerin and sensitivity to TRAIL-induced cell death in pancreatic ductal adenocarcinoma cells.
Pancreatic Neoplasms
MUTYH exon 7 and 13 mutations associated with colorectal cancer (MAP syndrome) are not commonly associated with sporadic pancreatic cancer.
Pancreatic Neoplasms
Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.
Pancreatic Neoplasms
Nanoparticle delivery of an AKT/PDK1 inhibitor improves the therapeutic effect in pancreatic cancer.
Pancreatic Neoplasms
Naturally Occurring T-Cell Response against Mutated p21 Ras Oncoprotein in Pancreatic Cancer.
Pancreatic Neoplasms
Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma.
Pancreatic Neoplasms
Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.
Pancreatic Neoplasms
Novel synthetic oleanane triterpenoid AMR-MeOAc inhibits K-Ras through ERK, Akt and survivin in pancreatic cancer cells.
Pancreatic Neoplasms
Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition.
Pancreatic Neoplasms
Occupational exposure to dyes, metals, polycyclic aromatic hydrocarbons and other agents and K-ras activation in human exocrine pancreatic cancer.
Pancreatic Neoplasms
Occupational exposure to organic solvents and K-ras mutations in exocrine pancreatic cancer.
Pancreatic Neoplasms
Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells.
Pancreatic Neoplasms
Oncolytic viral therapy for human pancreatic cancer cells by reovirus.
Pancreatic Neoplasms
Overexpression and biological function of IQGAP3 in human pancreatic cancer.
Pancreatic Neoplasms
p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma.
Pancreatic Neoplasms
p8 expression controls pancreatic cancer cell migration, invasion, adhesion and tumorigenesis.
Pancreatic Neoplasms
Pancreatic cancer cell radiation survival and prenyltransferase inhibition: the role of K-Ras.
Pancreatic Neoplasms
Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients.
Pancreatic Neoplasms
Pancreatic cancer inhibition by specific knockdown of K-ras mutant allele expression.
Pancreatic Neoplasms
Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.
Pancreatic Neoplasms
Patterns of genetic alterations in pancreatic cancer: a pooled analysis.
Pancreatic Neoplasms
Peritoneal washing cytology combined with immunocytochemical staining and detecting mutant K-ras in pancreatic cancer: comparison of the sensitivity and availability of various methods.
Pancreatic Neoplasms
Peroxisome proliferator-activated receptor gamma and regulations by the ubiquitin-proteasome system in pancreatic cancer.
Pancreatic Neoplasms
Phytohemagglutinin-L (PHA-L) lectin surface binding of N-linked beta 1-6 carbohydrate and its relationship to activated mutant ras in human pancreatic cancer cell lines.
Pancreatic Neoplasms
Polymerase chain reaction-based K-ras mutation detection of pancreatic adenocarcinoma in routine cytology smears.
Pancreatic Neoplasms
Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy.
Pancreatic Neoplasms
Predictive factors for pancreatic cancer in patients with chronic pancreatitis in association with K-ras gene mutation.
Pancreatic Neoplasms
Predictive signatures inform the effective repurposing of Decitabine to treat K-RAS-dependent Pancreatic Ductal Adenocarcinoma.
Pancreatic Neoplasms
Prevalence and clinical significance of combined K-ras mutation and p53 aberration in pancreatic adenocarcinoma.
Pancreatic Neoplasms
Prognostic significance of K-ras mutations in pancreatic cancer: a meta-analysis.
Pancreatic Neoplasms
Prognostic value of K-ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer.
Pancreatic Neoplasms
Promoting effect of a high-fat/high-protein diet in DMBA-induced ductal pancreatic cancer in rats.
Pancreatic Neoplasms
Prospective evaluation of the contribution of K-ras mutational analysis and CA 19.9 measurement to cytological diagnosis in patients with clinical suspicion of pancreatic cancer.
Pancreatic Neoplasms
Quantitative determination of K-ras mutations in pancreatic juice for diagnosis of pancreatic cancer using hybridization protection assay.
Pancreatic Neoplasms
Quantity of mutant K-ras gene in pancreatic secretions for diagnosis of pancreatic carcinoma with different assays: analysis of 100 patients.
Pancreatic Neoplasms
Rab27a plays a dual role in metastatic propensity of pancreatic cancer.
Pancreatic Neoplasms
RAB5A promotes the formation of filopodia in pancreatic cancer cells via the activation of cdc42 and ?1-integrin.
Pancreatic Neoplasms
Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro.
Pancreatic Neoplasms
Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.
Pancreatic Neoplasms
Radiosensitizing Effects of the Prenyltransferase Inhibitor AZD3409 against RAS Mutated Cell Lines.
Pancreatic Neoplasms
Rapid and Sensitive Assay of K-ras Mutations in Pancreatic Cancer by Electrochemical Detection with Ferrocenyl-naphthalene-diimide.
Pancreatic Neoplasms
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Pancreatic Neoplasms
Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
Pancreatic Neoplasms
Reassessment of K-ras mutations at codon 12 by direct PCR and sequencing from tissue microdissection in human pancreatic adenocarcinomas.
Pancreatic Neoplasms
Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers.
Pancreatic Neoplasms
Recombinant expression of different mutant K-ras gene in pancreatic cancer Bxpc-3 cells and its effects on chemotherapy sensitivity.
Pancreatic Neoplasms
Regulation of CD137 expression through K-Ras signaling in pancreatic cancer cells.
Pancreatic Neoplasms
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Pancreatic Neoplasms
Relationship of family cancer history to the expression of p53, p21WAF-1, HER-2/neu, and K-ras mutation in pancreatic adenocarcinoma.
Pancreatic Neoplasms
Remote partial gastrectomy as a risk factor for pancreatic cancer: potential for preventive strategies.
Pancreatic Neoplasms
Retraction notice to "Increased Ras GTPase activity is regulated by miRNAs that can be attenuated by CDF treatment in pancreatic cancer cells" [Cancer Lett. 319(2) (2012) 173-181].
Pancreatic Neoplasms
Retraction: "Activated K-Ras and INK4a/Arf Deficiency Promote Aggressiveness of Pancreatic Cancer by Induction of EMT Consistent With Cancer Stem Cell Phenotype" by Wang et al.
Pancreatic Neoplasms
Retraction: "Inactivation of Ink4a/Arf Leads to Deregulated Expression of miRNAs in K-Ras Transgenic Mouse Model of Pancreatic Cancer" by Ali et al.
Pancreatic Neoplasms
Retraction: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-?B Signaling Pathways.
Pancreatic Neoplasms
Ribozyme against mutant K-ras mRNA suppresses tumor growth of pancreatic cancer.
Pancreatic Neoplasms
RInhibiting K-ras Signaling Reserves the Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells and its Mechanisms.
Pancreatic Neoplasms
Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer.
Pancreatic Neoplasms
Role of RAF/MEK/ERK pathway, p-STAT-3 and Mcl-1 in sorafenib activity in human pancreatic cancer cell lines.
Pancreatic Neoplasms
Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer.
Pancreatic Neoplasms
Senescence in pancreatic carcinogenesis: from signalling to chromatin remodelling and epigenetics.
Pancreatic Neoplasms
Sensitization of Human Pancreatic Cancer Cells Harboring Mutated K-ras to Apoptosis.
Pancreatic Neoplasms
Serum concentrations of organochlorine compounds and K-ras mutations in exocrine pancreatic cancer. PANKRAS II Study Group.
Pancreatic Neoplasms
Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
Pancreatic Neoplasms
Significance of K-ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer.
Pancreatic Neoplasms
Simple and sensitive detection of K-ras gene mutations in human pancreatic cancers by nonradioisotopic single-strand conformation polymorphism analysis.
Pancreatic Neoplasms
SiRNA Delivery with PEGylated Graphene Oxide Nanosheets for Combined Photothermal and Genetherapy for Pancreatic Cancer.
Pancreatic Neoplasms
SKA1 regulates actin cytoskeleton remodelling via activating Cdc42 and influences the migration of pancreatic ductal adenocarcinoma cells.
Pancreatic Neoplasms
Stool testing for the early detection of pancreatic cancer: rationale and current evidence.
Pancreatic Neoplasms
Sulforaphane, quercetin and catechins complement each other in elimination of advanced pancreatic cancer by miR-let-7 induction and K-ras inhibition.
Pancreatic Neoplasms
Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA.
Pancreatic Neoplasms
Suppression of invasion of a hamster pancreatic cancer cell line by antisense oligonucleotides mutation-matched to K-ras gene.
Pancreatic Neoplasms
Suppression of pancreatic cancer by the dominant negative ras mutant, N116Y.
Pancreatic Neoplasms
Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells.
Pancreatic Neoplasms
Syndecan-2 promotes perineural invasion and cooperates with K-ras to induce an invasive pancreatic cancer cell phenotype.
Pancreatic Neoplasms
Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6.
Pancreatic Neoplasms
Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells.
Pancreatic Neoplasms
Synthetic 8-hydroxydeoxyguanosine inhibited metastasis of pancreatic cancer through concerted inhibitions of ERM and Rho-GTPase.
Pancreatic Neoplasms
Targeting EphA2 with miR-124 mediates Erlotinib resistance in K-RAS mutated pancreatic cancer.
Pancreatic Neoplasms
Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities.
Pancreatic Neoplasms
Targeting Mutated K-ras in Pancreatic Adenocarcinoma Using an Adjuvant Vaccine.
Pancreatic Neoplasms
Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion.
Pancreatic Neoplasms
Targeting the K-Ras--JNK axis eliminates cancer stem-like cells and prevents pancreatic tumor formation.
Pancreatic Neoplasms
Telomerase activity in pure pancreatic juice for the diagnosis of pancreatic cancer may be complementary to K-ras mutation.
Pancreatic Neoplasms
The Association Between Selected Risk Factors for Pancreatic Cancer and the Expression of p53 and K-ras Codon 12 Mutations.
Pancreatic Neoplasms
The dominant negative H-ras mutant, N116Y, suppresses growth of metastatic human pancreatic cancer cells in the liver of nude mice.
Pancreatic Neoplasms
The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-?B and RalB signaling pathways.
Pancreatic Neoplasms
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cells.
Pancreatic Neoplasms
The plasminogen activator system in pancreas cancer: role of t-PA in the invasive potential in vitro.
Pancreatic Neoplasms
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
Pancreatic Neoplasms
The Ras inhibitor S-trans,trans-farnesylthiosalicylic acid chemosensitizes human tumor cells without causing resistance.
Pancreatic Neoplasms
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.
Pancreatic Neoplasms
The Ratio of RAC1B to RAC1 Expression in Breast Cancer Cell Lines as a Determinant of Epithelial/Mesenchymal Differentiation and Migratory Potential.
Pancreatic Neoplasms
The regulatory roles of miRNA and methylation on oncogene and tumor suppressor gene expression in pancreatic cancer cells.
Pancreatic Neoplasms
The relative influence of diet and serum concentrations of organochlorine compounds on K-ras mutations in exocrine pancreatic cancer.
Pancreatic Neoplasms
The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.
Pancreatic Neoplasms
The Significance of p53 and K-ras Immunocytochemical Staining in the Diagnosis of Malignant Biliary Obstruction by Brush Cytology during ERCP.
Pancreatic Neoplasms
The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.
Pancreatic Neoplasms
The therapeutic effect of cytokine-induced killer cells on pancreatic cancer enhanced by dendritic cells pulsed with k-ras mutant Peptide.
Pancreatic Neoplasms
Therapeutic effect of c-Jun N-terminal kinase inhibition on pancreatic cancer.
Pancreatic Neoplasms
Tissue Transglutaminase (TG2)-Induced Inflammation in Initiation, Progression, and Pathogenesis of Pancreatic Cancer.
Pancreatic Neoplasms
Toll-like receptor 9 agonist IMO cooperates with cetuximab in K-ras mutant colorectal and pancreatic cancers.
Pancreatic Neoplasms
Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.
Pancreatic Neoplasms
Treatment of pancreatic cancer: current limitations, future possibilities.
Pancreatic Neoplasms
TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activation.
Pancreatic Neoplasms
Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.
Pancreatic Neoplasms
Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer.
Pancreatic Neoplasms
Unfavourable prognosis associated with K-ras gene mutation in pancreatic cancer surgical margins.
Pancreatic Neoplasms
Unique GGT --> GTT mutation at K-ras codon 12 in six human pancreatic cancer cell lines from Chinese patients.
Pancreatic Neoplasms
Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cells.
Pancreatic Neoplasms
Use of herbal medicines and natural products: an alternative approach to overcoming the apoptotic resistance of pancreatic cancer.
Pancreatic Neoplasms
Usefulness of K-ras gene mutation at codon 12 in bile for diagnosing biliary strictures.
Pancreatic Neoplasms
Validation of blood testing for K-ras mutations in colorectal and pancreatic cancer.
Pancreatic Neoplasms
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
Pancreatic Neoplasms
ZIP4 Promotes Muscle Wasting and Cachexia in Mice With Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells.
Pancreatic Neoplasms
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
Pancreatic Neoplasms
[Anti-pancreatic cancer immune response induced by K-ras mutated peptide]
Pancreatic Neoplasms
[Clinical significance of K-RAS and cytokeratine 20 markers in diagnosis of lymphogenic metastasis of pancreatic cancer]
Pancreatic Neoplasms
[Combinational effects of K-ras and IGF-IR antisense oligodeoxynucleotide on proliferation and apoptosis of human pancreatic cancer Patu8988 cells]
Pancreatic Neoplasms
[Combined detection of K-ras mutation and CA19-9 level in plasma of patients with pancreatic cancer]
Pancreatic Neoplasms
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
Pancreatic Neoplasms
[Detection of K-ras gene mutations in DNA extracted from the plasma of patients with pancreatic cancer]
Pancreatic Neoplasms
[Detection of point mutation of Kirsten ras oncogene in pancreatic carcinoma by polymerase chain reaction]
Pancreatic Neoplasms
[Detection of ras gene mutations of pancreatic tumors by polymerase chain reaction and direct sequencing method]
Pancreatic Neoplasms
[Developing a hospital-based high risk scoring model and screening strategy for pancreatic cancer]
Pancreatic Neoplasms
[Experiment study on the diagnostic value of bile K-ras gene mutation responsible to the hepatic metastasis of pancreatic cancer]
Pancreatic Neoplasms
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
Pancreatic Neoplasms
[K-ras mutations detection in paraaortic lymph nodes and its prognostic value after the surgical treatment of pancreas cancer]
Pancreatic Neoplasms
[Specific immune against pancreatic cancer induced by dendritic cells pulsed with mutant K-ras peptide]
Pancreatic Neoplasms
[The diagnostic value of serum carcinoma markers, fecal K-ras and p53 gene mutation in pancreatic cancers]
Pancreaticobiliary Maljunction
DPC-4 (Smad-4) and K-ras gene mutations in biliary tract epithelium in children with anomalous pancreaticobiliary ductal union.
Pancreaticobiliary Maljunction
K-ras and p53 gene mutations in noncancerous biliary lesions of patients with pancreaticobiliary maljunction.
Pancreaticobiliary Maljunction
K-ras point mutations in cancerous and noncancerous biliary epithelium in patients with pancreaticobiliary maljunction.
Pancreaticobiliary Maljunction
Proliferative potential and K-ras mutation in epithelial hyperplasia of the gallbladder in patients with anomalous pancreaticobiliary ductal union.
Pancreaticobiliary Maljunction
Relation between K-ras codon 12 mutation and p53 protein overexpression in gallbladder cancer and biliary ductal epithelia in patients with pancreaticobiliary maljunction.
Pancreatitis
An integrated approach for comparative proteomic analysis of human bile reveals overexpressed cancer-associated proteins in malignant biliary stenosis.
Pancreatitis
Different amounts of K-ras mutant epithelial cells in pancreatic carcinoma and mass-forming pancreatitis.
Pancreatitis
Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNA.
Pancreatitis
Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models.
Pancreatitis
Follow-Up Study of K-ras Mutations in the Plasma of Patients With Pancreatic Cancer: Correlation With Clinical Features and Carbohydrate Antigen 19-9.
Pancreatitis
Frequent RASSF1A promoter hypermethylation and K-ras mutations in pancreatic carcinoma.
Pancreatitis
Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis.
Pancreatitis
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Pancreatitis
p53 and K-ras mutations in pancreatic juice samples from patients with chronic pancreatitis.
Pancreatitis
Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.
Pancreatitis
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Pancreatitis
Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis.
Pancreatitis
Rab GTPase 21 mediates caerulin-induced TRAF3-MKK3-p38 activation and acute pancreatitis response.
Pancreatitis
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
Pancreatitis, Alcoholic
Frequent and Significant K-ras Mutation in the Pancreas, the Bile Duct, and the Gallbladder in Autoimmune Pancreatitis.
Pancreatitis, Chronic
A case of small pancreatic cancer diagnosed by serial follow-up studies promptly by a positive K-ras point mutation in pure pancreatic juice.
Pancreatitis, Chronic
Absence of K-ras mutations in the pancreatic parenchyma of patients with chronic pancreatitis.
Pancreatitis, Chronic
Analysis of K-ras codon 12 point mutations using duodenal lavage fluid for diagnosis of pancreatic carcinoma.
Pancreatitis, Chronic
Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease.
Pancreatitis, Chronic
Analysis of K-ras mutations in pancreatic tissue after fine needle aspirates.
Pancreatitis, Chronic
Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia.
Pancreatitis, Chronic
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Pancreatitis, Chronic
Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis.
Pancreatitis, Chronic
Clinical usefulness of K-ras gene mutation detection and cytology in pancreatic juice in the diagnosis and screening of pancreatic cancer.
Pancreatitis, Chronic
Detecting K-ras and p53 gene mutation from stool and pancreatic juice for diagnosis of early pancreatic cancer.
Pancreatitis, Chronic
Detection of K-ras gene mutation at codon 12 by pancreatic duct brushing for pancreatic cancer.
Pancreatitis, Chronic
Detection of K-ras gene mutations at codon 12 in the pancreatic juice of patients with intraductal papillary mucinous tumors of the pancreas.
Pancreatitis, Chronic
Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.
Pancreatitis, Chronic
Detection of K-ras point mutation and telomerase activity during endoscopic retrograde cholangiopancreatography in diagnosis of pancreatic cancer.
Pancreatitis, Chronic
Detection of K-ras point mutation at codon 12 in pancreatic diseases: a study in a Brazilian casuistic.
Pancreatitis, Chronic
Detection of p53 gene mutations in the supernatant of pancreatic juice and plasma from patients with pancreatic carcinomas.
Pancreatitis, Chronic
Detection of pancreatic carcinoma: diagnostic value of K-ras mutations in circulating DNA from serum.
Pancreatitis, Chronic
Detection of point mutation in K-ras oncogene at codon 12 in pancreatic diseases.
Pancreatitis, Chronic
Detection of point mutations in the K-ras oncogene at codon 12 in pure pancreatic juice for diagnosis of pancreatic carcinoma.
Pancreatitis, Chronic
Diagnosis of pancreatic cancer by cytology and measurement of oncogene and tumor markers in pure pancreatic juice aspirated by endoscopy.
Pancreatitis, Chronic
Diagnosis of pancreatic cancer by detecting telomerase activity in pancreatic juice: comparison with K-ras mutations.
Pancreatitis, Chronic
Diagnosis of pancreatic cancer by K-ras point mutation and cytology of pancreatic juice.
Pancreatitis, Chronic
Diagnosis of pancreatico-biliary malignancy: detection of gene mutations in plasma and stool.
Pancreatitis, Chronic
Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53.
Pancreatitis, Chronic
Early detection of pancreatic cancer in patients with chronic pancreatitis: diagnostic utility of a K-ras point mutation in the pancreatic juice.
Pancreatitis, Chronic
Evaluation of clinical relevance of examining K-ras, p16 and p53 mutations along with allelic losses at 9p and 18q in EUS-guided fine needle aspiration samples of patients with chronic pancreatitis and pancreatic cancer.
Pancreatitis, Chronic
Expression of Ki-67, p53, and K-ras in chronic pancreatitis and pancreatic ductal adenocarcinoma.
Pancreatitis, Chronic
Frequency of K-ras mutations in pancreatic intraductal neoplasias associated with pancreatic ductal adenocarcinoma and chronic pancreatitis: a meta-analysis.
Pancreatitis, Chronic
Frequent deletions of tumor suppressor genes in pure pancreatic juice from patients with tumoral or nontumoral pancreatic diseases.
Pancreatitis, Chronic
Genetic alterations in chronic pancreatitis: evidence for early occurrence of p53 but not K-ras mutations.
Pancreatitis, Chronic
K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance.
Pancreatitis, Chronic
K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
Pancreatitis, Chronic
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis.
Pancreatitis, Chronic
K-ras point mutations in the supernatants of pancreatic juice and bile are reliable for diagnosis of pancreas and biliary tract carcinomas complementary to cytologic examination.
Pancreatitis, Chronic
Long-term follow-up of chronic pancreatitis patients with K-ras mutation in the pancreatic juice.
Pancreatitis, Chronic
Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice.
Pancreatitis, Chronic
Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups.
Pancreatitis, Chronic
Molecular diagnosis of early pancreatic ductal adenocarcinoma in high-risk patients.
Pancreatitis, Chronic
Multiple K-ras mutations in hyperplasia and carcinoma in cases of human pancreatic carcinoma.
Pancreatitis, Chronic
p53 and K-ras mutations in pancreatic juice samples from patients with chronic pancreatitis.
Pancreatitis, Chronic
Predictive factors for pancreatic cancer in patients with chronic pancreatitis in association with K-ras gene mutation.
Pancreatitis, Chronic
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Pancreatitis, Chronic
Serum tumor markers and molecular biological diagnosis in pancreatic cancer.
Pancreatitis, Chronic
Significance of K-ras codon 12 point mutation in pancreatic juice in the diagnosis of carcinoma of the pancreas.
Pancreatitis, Chronic
Spirits and gastrectomy increase risk for chronic pancreatitis in Japanese male alcoholics.
Pancreatitis, Chronic
Telomerase activity in pure pancreatic juice for the diagnosis of pancreatic cancer may be complementary to K-ras mutation.
Pancreatitis, Chronic
The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma.
Pancreatitis, Chronic
Tumor angiogenesis in chronic pancreatitis and pancreatic adenocarcinoma: impact of K-ras mutations.
Pancreatitis, Chronic
Usufuleness of p16 and K-ras mutation in pancreatic adenocarcinoma and chronic pancreatitis differential diagnosis.
Pancreatitis, Chronic
Values of mutations of K-ras oncogene at codon 12 in detection of pancreatic cancer: 15-year experience.
Pancreatitis, Chronic
[An application value of detecting K-ras and p53 gene mutation in the stool and pure pancreatic juice for diagnosis of early pancreatic cancer]
Pancreatitis, Chronic
[Combined detection of K-ras mutation and CA19-9 level in plasma of patients with pancreatic cancer]
Pancreatitis, Chronic
[Detection of hepatic micrometastasis in ductal pancreatic carcinoma by K-ras mutation analysis and determination of clinical relevance]
Pancreatitis, Chronic
[K-ras mutation in pancreatic juice from patients with pancreatic carcinoma]
Pancreatitis, Chronic
[Mutation of the K-ras oncogene in pancreatic carcinoma, and application of its detection in pancreatic juice to diagnose pancreatic carcinoma]
Pancytopenia
Pancytopenia, Recurrent Infection, Poor Wound Healing, Heterotopia of the Brain Probably Associated with A Candidate Novel de Novo CDC42 Gene Defect: Expanding the Molecular and Phenotypic Spectrum.
Papilloma
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Papilloma
Antisera to the variable region of ras oncogene proteins, and specific detection of H-ras expression in an experimental model of chemical carcinogenesis.
Papilloma
Association between activated K-ras and c-erbB-2 oncogenes with "high-risk" and "low-risk" human papilloma virus types in preinvasive cervical lesions.
Papilloma
Biliary papillomatosis with the point mutation of K-ras gene arising in congenital choledochal cyst.
Papilloma
Both (+/-)syn- and (+/-)anti-7,12-dimethylbenz[a]anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at Codon 61 of c-H-ras.
Papilloma
Comparison of ras activation during epidermal carcinogenesis in vitro and in vivo.
Papilloma
Decreased focal adhesion kinase suppresses papilloma formation during experimental mouse skin carcinogenesis.
Papilloma
Detection of dibenzo[a,l]pyrene-induced H-ras codon 61 mutant genes in preneoplastic SENCAR mouse skin using a new PCR-RFLP method.
Papilloma
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Papilloma
Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia.
Papilloma
Expression of intermediate filament proteins by normal and transformed mouse epidermal-keratinocytes in culture.
Papilloma
H-ras mutations at codon 61 or 13 in tumors initiated with a NO donor in mouse skin.
Papilloma
Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice.
Papilloma
High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years.
Papilloma
Incidence of Harvey ras oncogene point mutations and their expression in methylbenzylnitrosamine-induced esophageal tumorigenesis.
Papilloma
Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis.
Papilloma
K-Ras and ?-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.
Papilloma
K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity.
Papilloma
Local cytokine treatment of HPV16-associated tumours results in inhibition of their lung metastases.
Papilloma
Loss of growth control by TGF-beta occurs at a late stage of mouse skin carcinogenesis and is independent of ras gene activation.
Papilloma
Pak1 and Pak2 are activated in recurrent respiratory papillomas, contributing to one pathway of Rac1-mediated COX-2 expression.
Papilloma
Reduction in IkappaB kinase alpha expression promotes the development of skin papillomas and carcinomas.
Papilloma
Targeted deletion of the H-ras gene decreases tumor formation in mouse skin carcinogenesis.
Papilloma
The neurofibromatosis type 1 (Nf1) tumor suppressor is a modifier of carcinogen-induced pigmentation and papilloma formation in C57BL/6 mice.
Papilloma
The prostaglandin receptor EP2 activates multiple signaling pathways and beta-arrestin1 complex formation during mouse skin papilloma development.
Papilloma
The role of polycyclic aromatic hydrocarbon-DNA adducts in inducing mutations in mouse skin.
Papilloma
The utility of the K6/ODC transgenic mouse as an alternative short term dermal model for carcinogenicity testing of pharmaceuticals.
Papilloma
Transgenic mice provide genetic evidence that transforming growth factor alpha promotes skin tumorigenesis via H-ras-dependent and H-ras-independent pathways.
Papilloma, Intraductal
New Variations in the Promoter Regions of Human DOCK4 and RAP1A Genes, and Coding Regions of RAP1A in Sporadic Breast Tumors.
Papillomavirus Infections
Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix.
Papillomavirus Infections
Coexistence of K-ras mutations and HPV infection in colon cancer.
Papillomavirus Infections
Detection of human papilloma virus (HPV) and K-ras mutations in human lung carcinomas.
Papillomavirus Infections
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Papillomavirus Infections
Human papillomavirus and colorectal cancer: evidences and pitfalls of published literature.
Papillomavirus Infections
Human Papillomavirus DNA and Oncogene Alterations in Colorectal Tumors.
Papillomavirus Infections
K-ras Mutation, HPV Infection and Smoking or Alcohol Abuse Positively Correlate with Esophageal Squamous Carcinoma.
Papillomavirus Infections
K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix.
Papillomavirus Infections
Significance of HPV Infection and Genic Mutation of APC and K-ras in Patients with Rectal Cancer.
Papillomavirus Infections
[Express of human papillomavirus, P53 and H-ras gene in laryngeal cancer]
Paraganglioma
Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours.
Paraganglioma
Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing.
Paralysis
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Paralysis
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Paralysis
Rab3A deletion selectively reduces spontaneous neurotransmitter release at the mouse neuromuscular synapse.
Paramyxoviridae Infections
Critical role of Rab11a-mediated recycling endosomes in the assembly of type I parainfluenza viruses.
Paramyxoviridae Infections
Rab27a facilitates human parainfluenza virus type 2 growth by promoting cell surface transport of envelope proteins.
Paraproteinemias
RAS mutations are uncommon in multiple myeloma and other monoclonal gammopathies.
Paraproteinemias
Reduction of serum IGF-I levels in patients affected with Monoclonal Gammopathies of undetermined significance or Multiple Myeloma. Comparison with bFGF, VEGF and K-ras gene mutation.
Parasitic Diseases
Enzymatically active Rho and Rac small-GTPases are involved in the establishment of the vacuolar membrane after Toxoplasma gondii invasion of host cells.
Paratuberculosis
The Mycobacterium avium subsp. paratuberculosis MAP3464 gene encodes an oxidoreductase involved in invasion of bovine epithelial cells through the activation of host cell Cdc42.
Parkinson Disease
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Parkinson Disease
Functional variant rs17525453 within RAB35 gene promoter is possibly associated with increased risk of Parkinson's disease in Taiwanese population.
Parkinson Disease
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Parkinson Disease
Overexpression of MicroRNA-133a Inhibits Apoptosis and Autophagy in a Cell Model of Parkinson's Disease by Downregulating Ras-Related C3 Botulinum Toxin Substrate 1 (RAC1).
Parkinson Disease
Rho GTPase regulation of ?-synuclein and VMAT2: Implications for pathogenesis of Parkinson's disease.
Parkinson Disease
Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2.
Parkinson Disease
Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia.
Parkinson Disease
The small GTPase activity of the ROC domain from LRRK2, a Parkinson's disease related protein.
Parkinson Disease
The Small GTPase RAC1/CED-10 Is Essential in Maintaining Dopaminergic Neuron Function and Survival Against ?-Synuclein-Induced Toxicity.
Parkinson Disease
Therapeutic effects of the Rho GTPase modulator CNF1 in a model of Parkinson's disease.
Parkinsonian Disorders
Clinical and Neuropathological Features Associated With Loss of RAB39B.
Parkinsonian Disorders
Distribution of Parkinson's disease associated RAB39B in mouse brain tissue.
Parkinsonian Disorders
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Parkinsonian Disorders
Sex differences in autophagy-mediated diseases: toward precision medicine.
Pemphigus
Pemphigus IgG causes skin splitting in the presence of both desmoglein 1 and desmoglein 3.
Peptic Ulcer
Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.
Peptic Ulcer
Past medical conditions and K-ras mutations in pancreatic ductal adenocarcinoma: a hypothesis-generating study.
Peri-Implantitis
LncRNA-mediated ceRNA network was identified as a crucial determinant of differential effects in periodontitis and periimplantitis by high-throughput sequencing.
Periodontitis
LncRNA-mediated ceRNA network was identified as a crucial determinant of differential effects in periodontitis and periimplantitis by high-throughput sequencing.
Peripheral Nerve Injuries
C3 exoenzyme lacks effects on peripheral axon regeneration in vivo.
Peripheral Nerve Injuries
Cdc42 Promotes Schwann Cell Proliferation and Migration Through Wnt/?-Catenin and p38 MAPK Signaling Pathway After Sciatic Nerve Injury.
Peripheral Nerve Injuries
Control of Axonal Growth and Regeneration of Sensory Neurons by the p110delta PI 3-Kinase.
Peripheral Nerve Injuries
MiR-7 inhibited peripheral nerve injury repair by affecting neural stem cells migration and proliferation through cdc42.
Peripheral Nervous System Diseases
An altered lipid metabolism characterizes Charcot-Marie-Tooth type 2B peripheral neuropathy.
Peripheral Nervous System Diseases
Exclusive expression of the Rab11 effector SH3TC2 in Schwann cells links integrin-?6 and myelin maintenance to Charcot-Marie-Tooth disease type 4C.
Peripheral Nervous System Diseases
IFN-?/mTORC1 decreased Rab11 in Schwann cells of diabetic peripheral neuropathy, inhibiting cell proliferation via GLUT1 downregulation.
Peripheral Nervous System Diseases
Myelin is dependent on the Charcot-Marie-Tooth Type 4H disease culprit protein FRABIN/FGD4 in Schwann cells.
Peripheral Nervous System Diseases
Novel role of Cdc42 and RalA GTPases in TNF-? mediated secretion of CCL2.
Persistent Infection
Rab27b regulates extracellular vesicle production in cells infected with Kaposi's sarcoma-associated herpesvirus to promote cell survival and persistent infection.
Peutz-Jeghers Syndrome
Gastric-type endocervical glandular neoplasms associated with aberrant p16 expression and K-RAS gene mutation in Peutz-Jeghers syndrome.
Peutz-Jeghers Syndrome
[Genome analyses for precancerous lesions in the gastrointestinal tract]
Pheochromocytoma
Absent ras gene mutations in human adrenal cortical neoplasms and pheochromocytomas.
Pheochromocytoma
Cdc42 and Rac1 activity is reduced in human pheochromocytoma and correlates with FARP1 and ARHGEF1 expression.
Pheochromocytoma
H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series.
Pheochromocytoma
Inhibition of Cdc42 and Rac1 activities in pheochromocytoma, the adrenal medulla tumor.
Pheochromocytoma
Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours.
Pheochromocytoma
Low frequency of ras gene mutations in neuroblastomas, pheochromocytomas, and medullary thyroid cancers.
Pheochromocytoma
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation.
Pheochromocytoma
Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2.
Pheochromocytoma
ras mutations in endocrine tumors: mutation detection by polymerase chain reaction-single strand conformation polymorphism.
Pheochromocytoma
Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades.
Pheochromocytoma
Sodium nitroprusside induces H-Ras depalmitoylation and alters the cellular response to hypoxia in differentiated and undifferentiated PC12 cells.
Pheochromocytoma
Somatic mutations in H-RAS in sporadic pheochromocytoma and paraganglioma identified by exome sequencing.
Pheochromocytoma
The effect of exogenous human ras and myc oncogenes in morphological differentiation of the rat pheochromocytoma PC12 cells.
Pheochromocytoma
The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.
Phyllodes Tumor
Development of mouse models of malignant phyllodes tumors by transplantation of syngeneic mammary gland cells expressing mutant H-Ras.
Pick Disease of the Brain
Altered Distribution of RhoA in Alzheimer's Disease and AbetaPP Overexpressing Mice.
Pick Disease of the Brain
Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.
Piebaldism
A founder RAB27A variant causes Griscelli syndrome type 2 with phenotypic heterogeneity in Qatari families.
Piebaldism
Biochemical and functional characterization of Rab27a mutations occurring in Griscelli syndrome patients.
Piebaldism
Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene.
Piebaldism
Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations.
Piebaldism
Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2.
Piebaldism
Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.
Pigmentation Disorders
Role of Rab family GTPases and their effectors in melanosomal logistics.
Pituitary Neoplasms
Immunocytochemical analysis of the synaptic proteins SNAP-25 and Rab3A in human pituitary adenomas. Overexpression of SNAP-25 in the mammmosomatotroph lineages.
Pituitary Neoplasms
MicroRNA-143 shows tumor suppressive effects through inhibition of oncogenic K-Ras in pituitary tumor.
Pituitary Neoplasms
Rab18 is reduced in pituitary tumors causing acromegaly and its overexpression reverts growth hormone hypersecretion.
Plasmacytoma
Extensive extramedullary disease in myeloma. An uncommon variant with features of poor prognosis and dedifferentiation.
Platelet Storage Pool Deficiency
The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background.
Pleural Effusion
Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination.
Pleural Effusion
Diagnostic value of the FHIT and p16 mRNA loss and the K-ras gene mutation in pleural fluids for malignant pleural effusion.
Pleural Effusion
[Expressions of 8-OH-dG, k-ras, and p53 genes in pleural effusion cells and their clinical significances]
Pleural Effusion, Malignant
Diagnostic value of the FHIT and p16 mRNA loss and the K-ras gene mutation in pleural fluids for malignant pleural effusion.
Pleural Effusion, Malignant
Differential mRNA expression of Toll-like receptors and their adaptors in pleural effusions.
Pneumococcal Infections
Immunization with pneumococcal elongation factor Tu enhances serotype-independent protection against Streptococcus pneumoniae infection.
Pneumococcal Infections
Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 4.
Pneumonia
Cdc42 and RhoB activation are required for mannose receptor-mediated phagocytosis by human alveolar macrophages.
Pneumonia
COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1? mediated tumor angiogenesis and proliferation.
Pneumonia
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice.
Pneumonia
Immunoproteomic to analysis the pathogenicity factors in leukopenia caused by Klebsiella pneumonia bacteremia.
Pneumonia
K-ras Mutations in Lung Tumors from NNK-treated Mice with Lipopolysaccharide-elicited Lung Inflammation.
Pneumonia
KLF4 regulates adult lung tumor-initiating cells and represses K-Ras-mediated lung cancer.
Pneumonia
Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia.
Pneumonia
Slit2 Regulates Attractive Eosinophil and Repulsive Neutrophil Chemotaxis through Differential srGAP1 Expression during Lung Inflammation.
Pneumonia
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.
Polycystic Kidney, Autosomal Dominant
Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease.
Polycythemia Vera
Leukemogenic risk of hydroxyurea therapy as a single agent in polycythemia vera and essential thrombocythemia: N- and K-ras mutations and microsatellite instability in chromosomes 5 and 7 in 69 patients.
Polydactyly
Loss of function IFT27 variants associated with an unclassified lethal fetal ciliopathy with renal agenesis.
Polyomavirus Infections
Identification of Rab18 as an Essential Host Factor for BK Polyomavirus Infection Using a Whole-Genome RNA Interference Screen.
Porcine Reproductive and Respiratory Syndrome
Direct Regulation of the NADPH Oxidase RBOHD by the PRR-Associated Kinase BIK1 during Plant Immunity.
Porcine Reproductive and Respiratory Syndrome
Expansion of pathogen recognition specificity in plants using pattern recognition receptors and artificially designed decoys.
Porcine Reproductive and Respiratory Syndrome
The Arabidopsis Leucine-Rich Repeat Receptor-Like Kinases BAK1/SERK3 and BKK1/SERK4 Are Required for Innate Immunity to Hemibiotrophic and Biotrophic Pathogens.
Porcine Reproductive and Respiratory Syndrome
The oomycete microbe-associated molecular pattern Pep-13 triggers SERK3/BAK1-independent plant immunity.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Defective K-Ras oncoproteins overcome impaired effector activation to initiate leukemia in vivo.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
H-ras and c-myc RNA expression in human T-cell ALL and in normal human lymphocytes.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
MEK and PI3K-AKT inhibitors synergistically block activated IL7 receptor signaling in T-cell acute lymphoblastic leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Synteny mapping of four genes from the short arm of human chromosome 19 to bovine chromosome 7.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
[Detection of K-ras and p-53 oncogene mutations in a patient with acute lymphoblastic leukemia before and after bone marrow transplantation]
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Genetic mutational profiling analysis of T cell acute lymphoblastic leukemia reveal mutant FBXW7 as a prognostic indicator for inferior survival.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Statins inhibit T-acute lymphoblastic leukemia cell adhesion and migration through Rap1b.
Premature Birth
Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.
Primary Immunodeficiency Diseases
A novel RAB27A mutation in a patient with Griscelli syndrome type 2.
Primary Immunodeficiency Diseases
Activation of compensatory pathways via Rac2 in the absence of the Cdc42 effector Wiskott-Aldrich syndrome protein in Dendritic cells.
Primary Immunodeficiency Diseases
EuroFlow Standardized Approach to Diagnostic Immunopheneotyping of Severe PID in Newborns and Young Children.
Primary Immunodeficiency Diseases
Oral features of Griscelli syndrome type II: A rare case report.
Primary Myelofibrosis
Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction.
Primary Myelofibrosis
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
Primary Myelofibrosis
Systemic Inflammation and Myelofibrosis in a Patient with Takenouchi-Kosaki Syndrome due to CDC42 Tyr64Cys Mutation.
prostaglandin-endoperoxide synthase deficiency
Genetic ablation of cyclooxygenase-2 in keratinocytes produces a cell-autonomous defect in tumor formation.
Prostatic Hyperplasia
Abnormal expression of Rab27B in prostatic epithelial cells of benign prostatic hyperplasia alters intercellular communication.
Prostatic Hyperplasia
In-silico identification and characterization of organic and inorganic chemical stress responding genes in yeast (Saccharomyces cerevisiae).
Prostatic Hyperplasia
Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident.
Prostatic Neoplasms
?3?1 Integrin Suppresses Prostate Cancer Metastasis via Regulation of the Hippo Pathway.
Prostatic Neoplasms
A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer.
Prostatic Neoplasms
A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice.
Prostatic Neoplasms
Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events.
Prostatic Neoplasms
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
Prostatic Neoplasms
Application of pyrosequencing technique for improved detection of K-Ras mutation in formalin-fixed and paraffin-embedded prostate carcinoma tissues in Chinese patients.
Prostatic Neoplasms
CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac.
Prostatic Neoplasms
Deregulation of the Rho GTPase, Rac1, suppresses cyclin-dependent kinase inhibitor p21(CIP1) levels in androgen-independent human prostate cancer cells.
Prostatic Neoplasms
Differential expression of ETS family members in prostate cancer tissues and androgen-sensitive and insensitive prostate cancer cell lines.
Prostatic Neoplasms
Downregulation of Rab23 in Prostate Cancer Inhibits Tumor Growth In Vitro and In Vivo.
Prostatic Neoplasms
ERBB2 increases metastatic potentials specifically in androgen-insensitive prostate cancer cells.
Prostatic Neoplasms
Evaluation and characterization of anti-RalA autoantibody as a potential serum biomarker in human prostate cancer.
Prostatic Neoplasms
Extracellular ATP enhances in vitro invasion of prostate cancer cells by activating Rho GTPase and upregulating MMPs expression.
Prostatic Neoplasms
H-ras expression, genetic instability, and acquisition of metastatic ability by rat prostatic cancer cells following v-H-ras oncogene transfection.
Prostatic Neoplasms
HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes.
Prostatic Neoplasms
In silico identification of key genes and signaling pathways targeted by a panel of signature microRNAs in prostate cancer.
Prostatic Neoplasms
Individual rac GTPases mediate aspects of prostate cancer cell and bone marrow endothelial cell interactions.
Prostatic Neoplasms
Induction of entosis in prostate cancer cells by nintedanib and its therapeutic implications.
Prostatic Neoplasms
Inhibition of Cdc42-intersectin interaction by small molecule ZCL367 impedes cancer cell cycle progression, proliferation, migration, and tumor growth.
Prostatic Neoplasms
Inhibition of the GTPase Rac1 Mediates the Antimigratory Effects of Metformin in Prostate Cancer Cells.
Prostatic Neoplasms
Inhibitor 9 Combined With Androgen Deprivation Therapy or Chemotherapy Delays the Malignant Behavior of Castration-Resistant Prostate Cancer Through K-Ras/PLC?/PKC? Signaling Pathway.
Prostatic Neoplasms
Insights into oncogenic mutations of plexin-B1 based on the solution structure of the Rho GTPase binding domain.
Prostatic Neoplasms
Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival.
Prostatic Neoplasms
K-ras and Wnt signaling synergize to accelerate prostate tumorigenesis in the mouse.
Prostatic Neoplasms
Ligand-independent activation of androgen receptors by Rho GTPase signaling in prostate cancer.
Prostatic Neoplasms
MiR-203 down-regulates Rap1A and suppresses cell proliferation, adhesion and invasion in prostate cancer.
Prostatic Neoplasms
miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells.
Prostatic Neoplasms
miR-769-5p is associated with prostate cancer recurrence and modulates proliferation and apoptosis of cancer cells.
Prostatic Neoplasms
miR?367?3p downregulates Rab23 expression and inhibits Hedgehog signaling resulting in the inhibition of the proliferation, migration, and invasion of prostate cancer cells.
Prostatic Neoplasms
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Prostatic Neoplasms
Mutations of ras genes are relatively frequent in Japanese prostate cancers: pointing to genetic differences between populations.
Prostatic Neoplasms
Novel Interaction between the Co-chaperone Cdc37 and Rho GTPase Exchange Factor Vav3 Promotes Androgen Receptor Activity and Prostate Cancer Growth.
Prostatic Neoplasms
Novel Regulation of Integrin Trafficking by Rab11-FIP5 in Aggressive Prostate Cancer.
Prostatic Neoplasms
Partial growth suppression of human prostate cancer cells by the Krev-1 suppressor gene.
Prostatic Neoplasms
Phenylboronic acid is a more potent inhibitor than boric acid of key signaling networks involved in cancer cell migration.
Prostatic Neoplasms
RAB27A, RAB27B and VPS36 are downregulated in advanced prostate cancer and show functional relevance in prostate cancer cells.
Prostatic Neoplasms
Ras mutation, irrespective of cell type and p53 status, determines a cell's destiny to undergo apoptosis by okadaic acid, an inhibitor of protein phosphatase 1 and 2A.
Prostatic Neoplasms
Reduction of pp32 expression in poorly differentiated pancreatic ductal adenocarcinomas and intraductal papillary mucinous neoplasms with moderate dysplasia.
Prostatic Neoplasms
Role of p115RhoGEF in the regulation of extracellular Ca(2+)-induced choline kinase activation and prostate cancer cell proliferation.
Prostatic Neoplasms
Targeting protein geranylgeranylation slows tumor development in a murine model of prostate cancer metastasis.
Prostatic Neoplasms
The Epigenetic Factor KDM2B Regulates EMT and Small GTPases in Colon Tumor Cells.
Prostatic Neoplasms
The non-canonical mechanism of ER stress-mediated progression of prostate cancer.
Prostatic Neoplasms
Trop-2 promotes prostate cancer metastasis by modulating ?1 integrin functions.
Prostatic Neoplasms
Vav3 enhances androgen receptor splice variant activity and is critical for castration-resistant prostate cancer growth and survival.
Prostatic Neoplasms
Vav3, a Rho GTPase guanine nucleotide exchange factor, increases during progression to androgen independence in prostate cancer cells and potentiates androgen receptor transcriptional activity.
Prostatic Neoplasms
[Role of Rho GTPase in inhibiting metastatic ability of human prostate cancer cell line PC-3 by omega-3 polyunsaturated fatty acid]
Prostatic Neoplasms
[Small RNA interference-mediated ADP-ribosylation factor 6 silencing inhibits proliferation, migration and invasion of human prostate cancer PC-3 cells].
Protein Deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Protein Deficiency
Early-onset colorectal cancer: A distinct entity with unique genetic features.
protein-synthesizing gtpase deficiency
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes.
Proteinuria
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Proteinuria
Nuclear factor of activated T-cells mediates RhoA-induced fibronectin upregulation in glomerular podocytes.
Proteinuria
Proteinuria and glomerular damage in Rab3A knockout mice chronically fed a high-glucose diet.
Proteinuria
Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.
Proteinuria
Role of guanine nucleotide exchange factor-H1 in complement-mediated RhoA activation in glomerular epithelial cells.
Proteinuria
Small Rab GTPases in Intracellular Vesicle Trafficking: The Case of Rab3A/Raphillin-3A Complex in the Kidney.
Pseudarthrosis
Mechanical microenvironments and protein expression associated with formation of different skeletal tissues during bone healing.
Pseudorabies
The US3 Protein of Pseudorabies Virus Drives Viral Passage across the Basement Membrane in Porcine Respiratory Mucosa Explants.
Psoriasis
Transcriptomic landscaping of core genes and pathways of mild and severe psoriasis vulgaris.
Pterygium
Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review).
Pulmonary Arterial Hypertension
Fluoxetine inhibits monocrotaline-induced pulmonary arterial remodeling involved in inhibition of RhoA-Rho kinase and Akt signalling pathways in rats.
Pulmonary Blastoma
p53 and K-ras mutational genotyping in pulmonary carcinosarcoma, spindle cell carcinoma, and pulmonary blastoma: implications for histogenesis.
Pulmonary Disease, Chronic Obstructive
Cdc42 participates in the occurrence of chronic obstructive pulmonary disease by regulating migration of inflammatory cells.
Pulmonary Disease, Chronic Obstructive
Exosomal expression of RAB27A and its related lncRNA Lnc-RNA-RP11-510M2 in lung cancer.
Pulmonary Disease, Chronic Obstructive
Promotion of Lung Carcinogenesis by COPD-like Airway Inflammation in a K-ras Induced Mouse Model.
Pulmonary Disease, Chronic Obstructive
Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease.
Pulmonary Disease, Chronic Obstructive
Tumor necrosis factor links chronic obstructive pulmonary disease and K-ras mutant lung cancer through induction of an immunosuppressive pro-tumor microenvironment.
Pulmonary Disease, Chronic Obstructive
[Effects of mTOR-Cdc42 signaling pathway on phagocytosis of alveolar macrophages in chronic obstructive pulmonary disease mice].
Pulmonary Edema
Critical role of the small GTPase RhoA in the development of pulmonary edema induced by Pseudomonas aeruginosa in mice.
Pulmonary Edema
Cytoprotective-selective Activated Protein C Attenuates P. aeruginosa-induced Lung Injury in Mice.
Pulmonary Fibrosis
Fasudil, a rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.
Pulmonary Fibrosis
Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis.
Pulmonary Sclerosing Hemangioma
Microsatellite and EGFR, HER2 and K-RAS analyses in sclerosing hemangioma of the lung.
Purpura, Thrombocytopenic, Idiopathic
Study of oncogenic transformation in ex vivo expanded mesenchymal cells, from paediatric bone marrow.
Rectal Neoplasms
Alcohol and the risk of colon and rectal cancer with mutations in the K-ras gene.
Rectal Neoplasms
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Rectal Neoplasms
Co-mutation of p53, K-ras genes and accumulation of p53 protein and its correlation to clinicopathological features in rectal cancer.
Rectal Neoplasms
Dietary folate intake and k-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Rectal Neoplasms
Different genetic features associated with colon and rectal carcinogenesis.
Rectal Neoplasms
Epidermal growth factor receptor gene copy number, K-ras mutation and pathological response to preoperative cetuximab, 5-FU and radiation therapy in locally advanced rectal cancer.
Rectal Neoplasms
Fat and K-ras mutations in sporadic colorectal cancer in The Netherlands Cohort Study.
Rectal Neoplasms
Genetic alterations of K-ras may reflect prognosis in stage III colon cancer patients below 60 years of age.
Rectal Neoplasms
Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Rectal Neoplasms
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinoma.
Rectal Neoplasms
p53 and K-ras gene mutations in carcinoma of the rectum among Finnish women.
Rectal Neoplasms
Reappraisal of K-ras and p53 gene mutations in the recurrence of Dukes' B2 rectal cancer after curative resection.
Rectal Neoplasms
Significance of HPV Infection and Genic Mutation of APC and K-ras in Patients with Rectal Cancer.
Rectal Neoplasms
The role of circulating tumor cells and K-ras mutations in patients with locally advanced rectal cancer: a prospective study.
Rectal Neoplasms
[A case of advanced rectal cancer treated with leucovorin, fluorouracil, and oxaliplatin plus panitumumab preoperative chemotherapy].
Rectal Neoplasms
[A case of remnant liver metastases after resection of liver metastases from rectal cancer following treatment with 5-FU, L-OHP and CPT-11, with markedly effective treatment by cetuximab plus S-1].
Rectal Neoplasms
[Mixed adenoneuroendocrine carcinoma with multiple liver metastases successfully treated by cetuximab/CPT-11 chemotherapy followed by curative resection - a case report].
Renal Insufficiency
Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.
Renal Insufficiency, Chronic
CDC42 promotes vascular calcification in chronic kidney disease.
Renal Insufficiency, Chronic
Rab27a dependent exosome releasing participated in albumin handling as a coordinated approach to lysosome in kidney disease.
Renal Insufficiency, Chronic
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Reperfusion Injury
Aberrant regulation of planar cell polarity in polycystic kidney disease.
Reperfusion Injury
Exosomes/microvesicles microRNA-423-3p derived from cardiac fibroblasts mediates the cardioprotective effects of ischemic postconditioning.
Reperfusion Injury
Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo.
Reperfusion Injury
Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats.
Reperfusion Injury
PKN1 Directs Polarized RAB21 Vesicle Trafficking via RPH3A and Is Important for Neutrophil Adhesion and Ischemia-Reperfusion Injury.
Reperfusion Injury
Spinal cord ischemia-reperfusion causes damage of neurocyte by inhibiting RAP2C.
Retinal Degeneration
CDC42 is required for tissue lamination and cell survival in the mouse retina.
Retinal Degeneration
Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases.
Retinal Degeneration
Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors.
Retinal Degeneration
The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa.
Retinal Neoplasms
Ras activation in retinal progenitor cells induces tumor formation in the eye.
Retinitis Pigmentosa
Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration.
Retinitis Pigmentosa
Isobaric Tags for Relative and Absolute Quantitation-Based Proteomic Analysis of Patent and Constricted Ductus Arteriosus Tissues Confirms the Systemic Regulation of Ductus Arteriosus Closure.
Retinitis Pigmentosa
Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein.
Retinitis Pigmentosa
The bacterial toxin CNF1 as a tool to induce retinal degeneration reminiscent of retinitis pigmentosa.
Retinitis Pigmentosa
The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic.
Retinoblastoma
Abnormal expression of the retinoblastoma gene in ovarian neoplasms and correlation to p53 and K-ras mutations.
Retinoblastoma
Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner.
Retinoblastoma
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Retinoblastoma
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
Retinoblastoma
Gene analysis of K-, H-ras, p53, and retinoblastoma susceptibility genes in human lung cancer cell lines by the polymerase chain reaction/single-strand conformation polymorphism method.
Retinoblastoma
Immunohistochemical analysis of MIB-1 proliferative activity in human endometrial cancer. Correlation with clinicopathological parameters, patient outcome, retinoblastoma immunoreactivity and K-ras codon 12 point mutations.
Retinoblastoma
Immunohistochemical and genetic analysis of non-small cell and small cell gallbladder carcinoma and their precursor lesions.
Retinoblastoma
Loss of Rb overrides the requirement for ERK activity for cell proliferation.
Retinoblastoma
Molecular markers in lung cancer: prognostic role and relationship to smoking.
Retinoblastoma
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Retinoblastoma
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Retinoblastoma
Rac and Cdc42 are potent stimulators of E2F-dependent transcription capable of promoting retinoblastoma susceptibility gene product hyperphosphorylation.
Retinoblastoma
Retinoblastoma protein (pRB) was significantly phosphorylated through a Ras-to-MAPK pathway in mutant K-ras stably transfected human adrenocortical cells.
Retinoblastoma
The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras.
Retroviridae Infections
Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts.
Rhabdoid Tumor
Cloning and characterization of a novel Rab-family gene, Rab36, within the region at 22q11.2 that is homozygously deleted in malignant rhabdoid tumors.
Rhabdoid Tumor
Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2.
Rhabdomyosarcoma
Cooperation of oncogenic K-ras and p53 deficiency in pleomorphic rhabdomyosarcoma development in adult mice.
Rhabdomyosarcoma
H-ras and K-ras mutations in soft tissue sarcoma: comparative studies of sarcomas from Korean and American patients.
Rhabdomyosarcoma
Influence of the H-ras oncogene on radiation responses of a rat rhabdomyosarcoma cell line.
Rhabdomyosarcoma
Mutational status of K-ras and TP53 genes in primary sarcomas of the heart.
Rhabdomyosarcoma
Participation of small GTPases Rac1 and Cdc42Hs in myoblast transformation.
Rhabdomyosarcoma
Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling.
Rhabdomyosarcoma, Embryonal
Detection of point mutations in N-ras and K-ras genes of human embryonal rhabdomyosarcomas using oligonucleotide probes and the polymerase chain reaction.
Rhabdomyosarcoma, Embryonal
T-cell acute lymphoblastic leukemia following therapy of rhabdomyosarcoma.
RNA Virus Infections
The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor-associated factor 3 (TRAF3).
Salmonella Infections
Salmonella-directed recruitment of new membrane to invasion foci via the host exocyst complex.
Sarcoidosis
A genome-wide association study reveals evidence of association with sarcoidosis at 6p12.1.
Sarcoma
?-Catenin Does Not Confer Tumorigenicity When Introduced into Partially Transformed Human Mesenchymal Stem Cells.
Sarcoma
A molecular approach to leukemogenesis: mouse lymphomas contain an activated c-ras oncogene.
Sarcoma
Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas.
Sarcoma
Activation of Ras overcomes B-cell tolerance to promote differentiation of autoreactive B cells and production of autoantibodies.
Sarcoma
Alkalinization of the lysosomes is correlated with ras transformation of murine and human fibroblasts.
Sarcoma
Analysis of p53 and K-ras genes and their proteins in a sarcoma botryoides of the uterine cervix.
Sarcoma
Analysis of the c-myc, K-ras and p53 genes in methylcholanthrene-induced mouse sarcomas.
Sarcoma
Association of minisatellite instability with c-myc amplification and K-ras mutation in methylcholanthrene-induced mouse sarcomas.
Sarcoma
Carcinosarcoma colliding osteosarcoma of the pancreas: a rare case report of multiple clonal originated pancreatic tumors.
Sarcoma
Changes in cellular gene expression in rat thyroid epithelial cells transformed by the Kirsten murine sarcoma virus.
Sarcoma
Chromosomal abnormalities and gene amplification in renal cancers induced in rats by nickel subsulfide.
Sarcoma
Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice.
Sarcoma
Contributions of intrinsic mutation rate and selfish selection to levels of de novo HRAS mutations in the paternal germline.
Sarcoma
Detection of a rare point mutation at codon 59 and relatively high incidence of H-ras mutation in Indian oral cancer.
Sarcoma
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product.
Sarcoma
Diagnostic value of K-ras mutation analysis for pancreaticobiliary cytology specimens with indeterminate diagnosis.
Sarcoma
Evidence that sprouty 2 is necessary for sarcoma formation by H-Ras oncogene-transformed human fibroblasts.
Sarcoma
Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins.
Sarcoma
Genomic and Metabolomic Analysis of Step-Wise Malignant Transformation in Human Skin Fibroblasts.
Sarcoma
GGT to GTT transversions in codon 12 of the K-ras oncogene in rat renal sarcomas induced with nickel subsulfide or nickel subsulfide/iron are consistent with oxidative damage to DNA.
Sarcoma
Glucocorticoid-enhanced neoplastic transformation of human keratinocytes by human papillomavirus type 16 and an activated ras oncogene.
Sarcoma
H-ras and K-ras gene mutations in primary human soft tissue sarcoma: concomitant mutations of the ras genes.
Sarcoma
H-ras and K-ras mutations in soft tissue sarcoma: comparative studies of sarcomas from Korean and American patients.
Sarcoma
H-ras oncogene activation in invasive UVR-induced corneal sarcomas of the opossum Monodelphis domestica.
Sarcoma
Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.
Sarcoma
Identification of a novel salivary biomarker miR-143-3p for periodontal diagnosis: A proof of concept study.
Sarcoma
Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma.
Sarcoma
Immunophenotype and K-RAS mutation in mucinous ovarian adenocarcinoma with mural nodule of high-grade sarcoma: case report.
Sarcoma
Inactivation of O(6)-methylguanine-DNA methyltransferase in soft tissue sarcomas: association with K-ras mutations.
Sarcoma
K-Ras gene status and expression of Ras/mitogen-activated protein kinase (MAPK) signaling molecules in ameloblastomas.
Sarcoma
Malignant transformation of an infinite life span human fibroblast cell strain by transfection with v-Ki-ras.
Sarcoma
Malignant transformation of human fibroblasts by oncogene transfection or carcinogen treatment.
Sarcoma
Molecular cloning, genomic analysis, and biological properties of rat leukemia virus and the onc sequences of Rasheed rat sarcoma virus.
Sarcoma
Mouse cells contain two distinct ras gene mRNA species that can be translated into a p21 onc protein.
Sarcoma
Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses.
Sarcoma
NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.
Sarcoma
Oncogenicity of human N-ras oncogene and proto-oncogene introduced into retroviral vectors.
Sarcoma
Ovarian mucinous tumor with malignant mural nodules: dedifferentiation or collision?
Sarcoma
Production of chimeric protein coded by the fused viral H-ras and human N-ras genes in Escherichia coli.
Sarcoma
Spatiotemporal metabolic dynamics of the photosensitizer talaporfin sodium in carcinoma and sarcoma.
Sarcoma
Targeting sphingosine kinase 1 (SK1) enhances oncogene-induced senescence through ceramide synthase 2 (CerS2)-mediated generation of very-long-chain ceramides.
Sarcoma
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.
Sarcoma
Upregulated miRNA-622 inhibited cell proliferation, motility, and invasion via repressing Kirsten rat sarcoma in glioblastoma.
Sarcoma, Avian
Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.
Sarcoma, Kaposi
Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma.
Schistosomiasis
Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients.
Schistosomiasis
[Regulatory effects of RhoGTPase on transition of liver sinusoidal capillarization: experiment with mice of schistosomal hepatic fibrosis]
Seizures
The first case of myoclonic epilepsy in a child with a de novo 22q11.2 microduplication.
Seminoma
Primary mediastinal and testicular seminomas: a comparison of K-ras-2 gene sequence and p53 immunoperoxidase analysis of 26 cases.
Sepsis
Comparative analysis of Histophilus somni IbpA with other FIC enzymes reveals differences in substrate and nucleotide specificities.
Sepsis
Potential role of lncRNA HULC/miR?128?3p/RAC1 axis in the inflammatory response during LPS?induced sepsis in HMEC?1 cells.
Severe Combined Immunodeficiency
EuroFlow Standardized Approach to Diagnostic Immunopheneotyping of Severe PID in Newborns and Young Children.
Severe Combined Immunodeficiency
Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo.
Sexually Transmitted Diseases
The Prevalence of HIV by Ethnic Group Is Correlated with HSV-2 and Syphilis Prevalence in Kenya, South Africa, the United Kingdom, and the United States.
Sigmoid Neoplasms
[A case of sigmoid colon cancer with liver and ovarian metastases effectively treated by panitumumab after acquiring resistance to prior chemotherapy regimens].
Sigmoid Neoplasms
[Two cases of metastatic colorectal cancer in wild-type K-RAS effectively treated by panitumumab].
Silicosis
A distinct mutational spectrum of p53 and K-ras genes in lung cancer of workers with silicosis.
Skin Neoplasms
Considerations for skin carcinogenesis experiments using inducible transgenic mouse models.
Skin Neoplasms
Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer.
Skin Neoplasms
Skin Cancers and the Contribution of Rho GTPase Signaling Networks to Their Progression.
Small Cell Lung Carcinoma
Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines.
Small Cell Lung Carcinoma
High TUBB3 expression, an independent prognostic marker in patients with early non small cell lung cancer (NSCLC) treated by preoperative chemotherapy, is regulated by K-Ras signaling pathway.
Small Cell Lung Carcinoma
microRNA-195 Promotes Small Cell Lung Cancer Cell Apoptosis via Inhibiting Rap2C Protein-Dependent MAPK Signal Transduction.
Small Cell Lung Carcinoma
No occurrence of DNA-polymerase Beta-gene mutation in human lung-carcinoma cell-lines with k-ras as, p53, or rb gene alterations.
Small Cell Lung Carcinoma
The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies.
small monomeric gtpase deficiency
A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development.
small monomeric gtpase deficiency
Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice.
small monomeric gtpase deficiency
Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis.
small monomeric gtpase deficiency
Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.
small monomeric gtpase deficiency
Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.
small monomeric gtpase deficiency
Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
small monomeric gtpase deficiency
Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development.
small monomeric gtpase deficiency
Cdc42 is required for male germline niche development in mice.
small monomeric gtpase deficiency
Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability.
small monomeric gtpase deficiency
Cdc42 regulates extracellular matrix remodeling in three dimensions.
small monomeric gtpase deficiency
Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells.
small monomeric gtpase deficiency
Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis.
small monomeric gtpase deficiency
Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver.
small monomeric gtpase deficiency
Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells.
small monomeric gtpase deficiency
Dynamin Binding Protein (Tuba) deficiency inhibits ciliogenesis and nephrogenesis in vitro and in vivo.
small monomeric gtpase deficiency
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
small monomeric gtpase deficiency
ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
small monomeric gtpase deficiency
Genetic deletion of Rab27B in pancreatic acinar cells affects granules size and has inhibitory effects on amylase secretion.
small monomeric gtpase deficiency
Parcas is the predominant Rab11-GEF for rhodopsin transport in Drosophila photoreceptors.
small monomeric gtpase deficiency
Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization.
small monomeric gtpase deficiency
Podocyte-specific loss of cdc42 leads to congenital nephropathy.
small monomeric gtpase deficiency
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
small monomeric gtpase deficiency
RAB GTPASE HOMOLOG 8D is required for the maintenance of both the root stem cell niche and the meristem.
small monomeric gtpase deficiency
Rab11-mediated focal adhesion turnover in sarcoma cell migration.
small monomeric gtpase deficiency
Rab27a and Rab27b regulate neutrophil azurophilic granule exocytosis and NADPH oxidase activity by independent mechanisms.
small monomeric gtpase deficiency
Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion.
small monomeric gtpase deficiency
Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.
small monomeric gtpase deficiency
Rab3a is critical for trapping alpha-MSH granules in the high Ca²?-affinity pool by preventing constitutive exocytosis.
small monomeric gtpase deficiency
Rab3a-mediated vesicle recruitment regulates short-term plasticity at the mouse diaphragm synapse.
small monomeric gtpase deficiency
Rab8a Deficiency in Skeletal Muscle Causes Hyperlipidemia and Hepatosteatosis by Impairing Muscle Lipid Uptake and Storage.
small monomeric gtpase deficiency
Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response.
small monomeric gtpase deficiency
Rap1b is required for normal platelet function and hemostasis in mice.
small monomeric gtpase deficiency
Rational targeting Cdc42 restrains Th2 cell differentiation and prevents allergic airway inflammation.
small monomeric gtpase deficiency
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
small monomeric gtpase deficiency
Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow.
small monomeric gtpase deficiency
Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.
small monomeric gtpase deficiency
The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice.
small monomeric gtpase deficiency
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
small monomeric gtpase deficiency
The Small GTPase Cdc42 Negatively Regulates the Formation of Neutrophil Extracellular Traps by Engaging Mitochondria.
small monomeric gtpase deficiency
The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.
small monomeric gtpase deficiency
Vascular endothelial Cdc42 deficiency delays skin wound-healing processes by increasing IL-1? and TNF-? expression.
small monomeric gtpase deficiency
Warburg Micro syndrome is caused by RAB18 deficiency or dysregulation.
Spasms, Infantile
Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.
Spinal Cord Injuries
Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair.
Spinal Cord Injuries
Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration.
Spinal Cord Injuries
Lesional RhoA+ cell numbers are suppressed by anti-inflammatory, cyclooxygenase-inhibiting treatment following subacute spinal cord injury.
Spinal Cord Injuries
microRNA-331-3p attenuates neuropathic pain following spinal cord injury via targeting RAP1A.
Spinal Cord Injuries
Prolonged lesional expression of RhoA and RhoB following spinal cord injury.
Spinal Cord Injuries
RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Amplification of wild-type K-ras promotes growth of head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Comprehensive Mutation Analysis of PIK3CA, p14ARF, p16INK4a and p21Waf1/Cip1 Genes is Suggestive of a Non- Neoplastic Nature of Phenytoin Induced Gingival Overgrowth.
Squamous Cell Carcinoma of Head and Neck
Does Harvey-Ras gene expression lead to oral squamous cell carcinoma? A clinicopathological aspect.
Squamous Cell Carcinoma of Head and Neck
ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition.
Squamous Cell Carcinoma of Head and Neck
Expression and mutation analysis of epidermal growth factor receptor in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.
Squamous Cell Carcinoma of Head and Neck
Histone deacetylase inhibitors suppress aggressiveness of head and neck squamous cell carcinoma via histone acetylation-independent blockade of the EGFR-Arf1 axis.
Squamous Cell Carcinoma of Head and Neck
Identification of insulin-like growth factor binding protein-3 as a farnesyl transferase inhibitor SCH66336-induced negative regulator of angiogenesis in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Identification of RAB2A and PRDX1 as the potential biomarkers for oral squamous cell carcinoma using mass spectrometry-based comparative proteomic approach.
Squamous Cell Carcinoma of Head and Neck
Imipramine blue halts head and neck cancer invasion through promoting F-box and leucine-rich repeat protein 14-mediated Twist1 degradation.
Squamous Cell Carcinoma of Head and Neck
Impact of K-Ras Over-expression in Laryngeal Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
K-RAS mutations in laryngeal squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Localization of H-ras mRNA in oral squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
MERTK as a novel therapeutic target in head and neck cancer.
Squamous Cell Carcinoma of Head and Neck
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras.
Squamous Cell Carcinoma of Head and Neck
MiR-181d functions as a potential tumor suppressor in oral squamous cell carcinoma by targeting K-ras.
Squamous Cell Carcinoma of Head and Neck
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma [Retraction].
Squamous Cell Carcinoma of Head and Neck
MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Overexpression of Rac-1 small GTPase binding protein in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.
Squamous Cell Carcinoma of Head and Neck
Prevalence of K-ras Codon 12 Mutations in Indian Patients with Head and Neck Cancer.
Squamous Cell Carcinoma of Head and Neck
Prevalence of K-RAS Codons 12 and 13 Mutations in Locally Advanced Head and Neck Squamous Cell Carcinoma and Impact on Clinical Outcomes.
Squamous Cell Carcinoma of Head and Neck
Prognostic significance of molecular markers in oral squamous cell carcinoma: A multivariate analysis.
Squamous Cell Carcinoma of Head and Neck
Rab18 Regulates Proliferation, Invasion and Cisplatin Sensitivity Through STAT3 Signaling in Head and Neck Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC).
Squamous Cell Carcinoma of Head and Neck
Ral GTPase Activation by Downregulation of RalGAP Enhances Oral Squamous Cell Carcinoma Progression.
Squamous Cell Carcinoma of Head and Neck
Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma.
Squamous Cell Carcinoma of Head and Neck
Repression of bone morphogenetic protein 4 by let-7i attenuates mesenchymal migration of head and neck cancer cells.
Squamous Cell Carcinoma of Head and Neck
S100A7 has an oncogenic role in oral squamous cell carcinoma by activating p38/MAPK and RAB2A signaling pathway.
Squamous Cell Carcinoma of Head and Neck
Schedule-dependent interaction between temsirolimus and cetuximab in head and neck cancer: a preclinical study.
Squamous Cell Carcinoma of Head and Neck
Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway.
Squamous Cell Carcinoma of Head and Neck
Studies on the Contribution of Cox-2 Expression in the Progression of Oral Squamous Cell Carcinoma and H-Ras Activation.
Squamous Cell Carcinoma of Head and Neck
The amplification of c-erb-B2 in cancer-free surgical margins is a predictor of poor outcome in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Wnt5b promotes the cell motility essential for metastasis of oral squamous cell carcinoma through active Cdc42 and RhoA.
Squamous Cell Carcinoma of Head and Neck
[The expressions of K-ras in human laryngeal squamous cell carcinoma cell lines (Hep-2) and its significance]
Starvation
Distinctive Responses to Nitrogen Starvation in the Dominant Active Mutants of the Fission Yeast Rheb GTPase.
Starvation
Fission Yeast Rho5p GTPase Is a Functional Paralogue of Rho1p That Plays a Role in Survival of Spores and Stationary-Phase Cells.
Starvation
Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes.
Starvation
Phosphatidylinositol 3-kinase, Cdc42, and Rac1 act downstream of Ras in integrin-dependent neurite outgrowth in N1E-115 neuroblastoma cells.
Starvation
Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.
Starvation
Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth.
Starvation
Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion.
Starvation
Stress resistance conferred by neuronal expression of dominant-negative Rac in adult Drosophila melanogaster.
Starvation
Stress-mediated inhibition of the classical nuclear protein import pathway and nuclear accumulation of the small GTPase Gsp1p.
Starvation
The elongation factor Tu from Escherichia coli, aminoacyl-tRNA, and guanosine tetraphosphate form a ternary complex which is bound by programmed ribosomes.
Starvation
Transcriptional Regulation Buffers Gene Dosage Effects on a Highly Expressed Operon in Salmonella.
Starvation
Translation inhibition reveals interaction of 2'-deoxy and 2'-O-methyl molecular beacons with mRNA targets in living cells.
Stomach Diseases
Quantitative analysis of representative proteome components and clustering of Helicobacter pylori clinical strains.
Stomach Neoplasms
Analysis of p53, K-ras gene mutation & Helicobacter pylori infection in patients with gastric cancer & peptic ulcer disease at a tertiary care hospital in north India.
Stomach Neoplasms
APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes.
Stomach Neoplasms
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Stomach Neoplasms
Augmentation of immune response by an analog of the antigenic peptide in a human T-cell clone recognizing mutated Ras-derived peptides.
Stomach Neoplasms
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency.
Stomach Neoplasms
BRAF/K-ras mutation, microsatellite instability, and promoter hypermethylation of hMLH1/MGMT in human gastric carcinomas.
Stomach Neoplasms
Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 cases.
Stomach Neoplasms
Correlation of COX-2 and K-ras expression to clinical outcome in gastric cancer.
Stomach Neoplasms
E-cadherin and K-ras: implications of a newly developed model of gastric cancer.
Stomach Neoplasms
Effects of CDC42 on the proliferation and invasion of gastric cancer cells.
Stomach Neoplasms
Effects of microRNA-29 family members on proliferation and invasion of gastric cancer cell lines.
Stomach Neoplasms
EGF Stimulates Rab35 Activation and Gastric Cancer Cell Migration by Regulating DENND1A-Grb2 Complex Formation.
Stomach Neoplasms
Expression of RAP1B is associated with poor prognosis and promotes an aggressive phenotype in gastric cancer.
Stomach Neoplasms
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.
Stomach Neoplasms
FARP1 boosts CDC42 activity from integrin ?v?5 signaling and correlates with poor prognosis of advanced gastric cancer.
Stomach Neoplasms
Frequent overexpression, but not activation by point mutation, of ras genes in primary human gastric cancers.
Stomach Neoplasms
Genetic mutations of p53 and k-ras in gastric carcinoma patients from Hunan, China.
Stomach Neoplasms
Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene.
Stomach Neoplasms
In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype.
Stomach Neoplasms
Inhibition by D-limonene of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
Stomach Neoplasms
Integrative genomics identifies RAB23 as an invasion mediator gene in diffuse-type gastric cancer.
Stomach Neoplasms
K-RAS mutation in gastric cancer and its link with microsatellite instability status.
Stomach Neoplasms
K-ras mutation in helicobacter pylori-associated chronic gastritis in patients with and without gastric cancer.
Stomach Neoplasms
K-ras mutations and cell kinetics in Helicobacter pylori associated gastric intestinal metaplasia: a comparison before and after eradication in patients with chronic gastritis and gastric cancer.
Stomach Neoplasms
Knockdown of Rap1b Enhances Apoptosis and Autophagy in Gastric Cancer Cells via the PI3K/Akt/mTOR Pathway.
Stomach Neoplasms
Knockdown of RAP2A gene expression suppresses cisplatin resistance in gastric cancer cells.
Stomach Neoplasms
Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37.
Stomach Neoplasms
MICAL2 Facilitates Gastric Cancer Cell Migration via MRTF-A-Mediated CDC42 Activation.
Stomach Neoplasms
MicroRNA-31 inhibits RhoA-mediated tumor invasion and chemotherapy resistance in MKN-45 gastric adenocarcinoma cells.
Stomach Neoplasms
MicroRNA-4268 inhibits cell proliferation via AKT/JNK signalling pathways by targeting Rab6B in human gastric cancer.
Stomach Neoplasms
Microsatellite instability and K-ras mutations in gastric adenomas, with reference to associated gastric cancers.
Stomach Neoplasms
miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer.
Stomach Neoplasms
miR-137 Is Frequently Down-Regulated in Gastric Cancer and Is a Negative Regulator of Cdc42.
Stomach Neoplasms
miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis.
Stomach Neoplasms
miR-182-5p improves the viability, mitosis, migration, and invasion ability of human gastric cancer cells by down-regulating RAB27A.
Stomach Neoplasms
MiR-455-5p acts as a novel tumor suppressor in gastric cancer by down-regulating RAB18.
Stomach Neoplasms
Mutational analysis of BRAF and K-ras in gastric cancers: absence of BRAF mutations in gastric cancers.
Stomach Neoplasms
NKX6.3 Is a Transcription Factor for Wnt/?-catenin and Rho-GTPase Signaling-Related Genes to Suppress Gastric Cancer Progression.
Stomach Neoplasms
Nuclear translocation of small G protein RhoA via active transportation in gastric cancer cells.
Stomach Neoplasms
Nucleotide variants within the IQGAP1 gene in diffuse-type gastric cancers.
Stomach Neoplasms
Organ-specific profiles of genetic changes in cancers caused by activation-induced cytidine deaminase expression.
Stomach Neoplasms
Phosphorylation of Ephrin-B1 Regulates Dissemination of Gastric Scirrhous Carcinoma.
Stomach Neoplasms
Phosphorylation of ephrin-B1 regulates dissemination of gastric scirrhous carcinoma.
Stomach Neoplasms
RAB13 as a novel prognosis marker promotes proliferation and chemotherapeutic resistance in gastric cancer.
Stomach Neoplasms
Rab18 overexpression promotes proliferation and chemoresistance through regulation of mitochondrial function in human gastric cancer.
Stomach Neoplasms
Rab3IP interacts with SSX2 and enhances the invasiveness of gastric cancer cells.
Stomach Neoplasms
RCC2 Interacts with Small GTPase RalA and Regulates Cell Proliferation and Motility in Gastric Cancer.
Stomach Neoplasms
Reversal of the malignant phenotype of gastric cancer cells by inhibition of RhoA expression and activity.
Stomach Neoplasms
Rho GTPase RhoJ is Associated with Gastric Cancer Progression and Metastasis.
Stomach Neoplasms
Roles of E-cadherin and Noncoding RNAs in the Epithelial-mesenchymal Transition and Progression in Gastric Cancer.
Stomach Neoplasms
S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.
Stomach Neoplasms
Studies on the relationship between the point mutation of ras oncogenes and the prognosis of patients with gastric cancer.
Stomach Neoplasms
Telomerase activity and its clinicopathological significance in gastric cancer.
Stomach Neoplasms
TGF-beta signaling pathway inactivation and cell cycle deregulation in the development of gastric cancer: role of the beta-spectrin, ELF.
Stomach Neoplasms
The microRNA-367 Inhibits the Invasion and Metastasis of Gastric Cancer by Directly Repressing Rab23.
Stomach Neoplasms
The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42.
Stomach Neoplasms
The role of ras gene mutation in gastric cancer and precancerous lesions.
Stomach Neoplasms
Traditional Chinese medicine Jianpi Bushen therapy suppresses the onset of pre-metastatic niche in a murine model of spontaneous lung metastasis.
Stomach Neoplasms
Transcriptome Analysis of the Inhibitory Effect of Astaxanthin on Helicobacter pylori-Induced Gastric Carcinoma Cell Motility.
Stomach Neoplasms
Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cells.
Stomach Neoplasms
UBE2C Is a Potential Biomarker of Intestinal-Type Gastric Cancer With Chromosomal Instability.
Stomach Neoplasms
Upregulated expression of ROCK1 promotes cell proliferation by functioning as a target of miR-335-5p in non-small cell lung cancer.
Stomach Neoplasms
Upregulation of miR-802 suppresses gastric cancer oncogenicity via targeting RAB23 expression.
Stomach Neoplasms
[Characteristics of plasma DNA and its application for detection of K-ras gene mutation]
Stomach Neoplasms
[Detection of G-->T mutation at codon 12 of H-ras oncogenes in gastric cancers with polymerase chain reaction and oligodeoxynucleotide(PCR-ODN)]
Stomach Neoplasms
[Detection of ras gene mutation in various stages of gastric cancer by PCR/RFLP SSCP and DNA sequencing]
Stomach Neoplasms
[Expression and mutation of p53 and H-ras genes in the carcinogenesis and development of gastric adenocarcinoma induced by MNNG in rats]
Stomach Neoplasms
[Research advances of K-ras mutation in the prognosis and targeted therapy of gastric cancer].
Stomach Neoplasms
[Study on association between an H-RAS gene polymorphism and gastric cancer development]
Stomach Neoplasms
[The roles of H. pylori infection and K-ras gene mutation in gastric carcinogenesis]
Stomatitis
Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells.
Strabismus
The Formin DAAM Functions as Molecular Effector of the Planar Cell Polarity Pathway during Axonal Development in Drosophila.
Stroke
Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.
Stroke
Rab7b Overexpression-Ameliorated Ischemic Brain Damage Following tMCAO Involves Suppression of TLR4 and NF-?B p65.
Stroke
Rac1-Mediated Effects of HMG-CoA Reductase Inhibitors (Statins) in Cardiovascular Disease.
Stroke
Ras-Related C3 Botulinum Toxin Substrate 1 Promotes Axonal Regeneration after Stroke in Mice.
Stroke
Role of Rac1 GTPase in NADPH oxidase activation and cognitive impairment following cerebral ischemia in the rat.
Stroke, Lacunar
Aldynoglia cells and modulation of RhoGTPase activity as useful tools for spinal cord injury repair.
Superinfection
Baculovirus induces host cell aggregation via a Rho/Rok-dependent mechanism.
Supranuclear Palsy, Progressive
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
Supranuclear Palsy, Progressive
Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.
Syndactyly
Carpenter syndrome: extended RAB23 mutation spectrum and analysis of nonsense-mediated mRNA decay.
Synucleinopathies
The GTPase Rab27b regulates the release, autophagic clearance, and toxicity of ?-synuclein.
Synucleinopathies
The small GTPase Rab11 co-localizes with ?-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
Syphilis
The Prevalence of HIV by Ethnic Group Is Correlated with HSV-2 and Syphilis Prevalence in Kenya, South Africa, the United Kingdom, and the United States.
Tangier Disease
Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier disease and Werner syndrome.
Tangier Disease
Decreased expression of a member of the Rho GTPase family, Cdc42Hs, in cells from Tangier disease - the small G protein may play a role in cholesterol efflux.
Teratoma
K-ras proto-oncogene exhibits tumor suppressor activity as its absence promotes tumorigenesis in murine teratomas.
Testicular Neoplasms
Overexpression of RhoA, Rac1, and Cdc42 GTPases is associated with progression in testicular cancer.
Thrombasthenia
Rap1b association with the platelet cytoskeleton occurs in the absence of glycoproteins IIb/IIIa.
Thrombocythemia, Essential
Leukemogenic risk of hydroxyurea therapy as a single agent in polycythemia vera and essential thrombocythemia: N- and K-ras mutations and microsatellite instability in chromosomes 5 and 7 in 69 patients.
Thrombocytopenia
De novo missense variants in the RAP1B gene identified in two patients with syndromic thrombocytopenia.
Thrombocytopenia
Further evidence of a mutation in CDC42 as a cause of a recognizable syndromic form of thrombocytopenia.
Thrombocytopenia
Macrothrombocytopenia and developmental delay with a de novo CDC42 mutation: Yet another locus for thrombocytopenia and developmental delay.
Thrombocytopenia
Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets.
Thrombocytopenia
Pathogenetic basis of Takenouchi-Kosaki syndrome: Electron microscopy study using platelets in patients and functional studies in a Caenorhabditis elegans model.
Thrombocytopenia
Polymorphism T81C in H-RAS Oncogene Is Associated With Disease Progression in Imatinib (TKI) Treated Chronic Myeloid Leukemia Patients.
Thrombosis
A Functional Relevance of the Anaphylatoxin Receptor C3aR for Platelet Function and Arterial Thrombus Formation Marks an Intersection Point Between Innate Immunity and Thrombosis.
Thrombosis
Amyloid ?-peptide-dependent activation of human platelets: essential role for Ca2+ and ADP in aggregation and thrombus formation.
Thrombosis
Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis.
Thrombosis
MUNC13-4 IS CRITICAL FOR THROMBOSIS THROUGH REGULATING RELEASE OF ADP FROM PLATELETS.
Thrombosis
Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.
Thrombosis
Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.
Thrombosis
Porphyromonas gingivalis lipopolysaccharide activates platelet Cdc42 and promotes platelet spreading and thrombosis.
Thrombosis
Rho GTPase regulation of reactive oxygen species generation and signalling in platelet function and disease.
Thrombosis
TC21/RRas2 regulates glycoprotein VI-FcR?-mediated platelet activation and thrombus stability.
Thrombosis
The GRAF family member Oligophrenin1 is a RhoGAP with a BAR domain and regulates Rho GTPases in platelets.
Thrombosis
The Small GTPase Rap1b: A Bidirectional Regulator of Platelet Adhesion Receptors.
Thymoma
Cetyltrimethylammonium Bromide Suppresses the Migration and Invasion of Hepatic Mahlavu Cells by Modulating Fibroblast Growth Factor Signaling.
Thymoma
Diagnosis of thymic epithelial tumor subtypes by a quantitative proteomic approach.
Thyroid Cancer, Papillary
A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples.
Thyroid Cancer, Papillary
BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort.
Thyroid Cancer, Papillary
Expression of p21 ras protein as a prognostic factor in papillary thyroid cancer.
Thyroid Cancer, Papillary
Prevalence of RAS Point Mutations in Papillary Thyroid Carcinoma; A Novel Mutation at Codon 31 of K-RAS.
Thyroid Cancer, Papillary
RAC1b overexpression stimulates proliferation and NF-kB-mediated anti-apoptotic signaling in thyroid cancer cells.
Thyroid Cancer, Papillary
The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a.
Thyroid Carcinoma, Anaplastic
Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors.
Thyroid Neoplasms
Absence of H- and K-ras oncogene mutations in sporadic medullary thyroid carcinoma.
Thyroid Neoplasms
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer.
Thyroid Neoplasms
Association between H-RAS T81C genetic polymorphism and gastrointestinal cancer risk: a population based case-control study in China.
Thyroid Neoplasms
Berberine could inhibit thyroid carcinoma cells by inducing mitochondrial apoptosis, G0/G1 cell cycle arrest and suppressing migration via PI3K-AKT and MAPK signaling pathways.
Thyroid Neoplasms
BRAF and K-RAS mutation in a Greek papillary and medullary thyroid carcinoma cohort.
Thyroid Neoplasms
BRAFV600E mutation: a potential predictor of more than a Sistrunk's procedure in patients with thyroglossal duct cyst carcinoma and a normal thyroid gland.
Thyroid Neoplasms
CircHIPK3 Promotes Thyroid Cancer Tumorigenesis and Invasion through the Mirna-338-3p/RAB23 Axis.
Thyroid Neoplasms
Deletion of Rap1b, but not Rap1a or Epac1, Reduces Protein Kinase A-Mediated Thyroid Cancer.
Thyroid Neoplasms
Downregulation of survivin and aurora a by histone deacetylase and RAS inhibitors: A new drug combination for cancer therapy.
Thyroid Neoplasms
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.
Thyroid Neoplasms
Exogenous Hydrogen Sulfide Regulates the Growth of Human Thyroid Carcinoma Cells.
Thyroid Neoplasms
Expression of bcl-2, c-erbB-2, p53, and p21 (waf1-cip1) protein in thyroid carcinomas.
Thyroid Neoplasms
Functional Significance of the Novel H-RAS Gene Mutation M72I in a Patient with Medullary Thyroid Cancer.
Thyroid Neoplasms
Galectin-3 promotes chronic activation of K-Ras and differentiation block in malignant thyroid carcinomas.
Thyroid Neoplasms
Ginsenoside Rg3 Inhibition of Thyroid Cancer Metastasis Is Associated with Alternation of Actin Skeleton.
Thyroid Neoplasms
H-RAS 81 polymorphism is significantly associated with aneuploidy in follicular tumors of the thyroid.
Thyroid Neoplasms
Highly Sensitive and Specific Molecular Test for Mutations in the Diagnosis of Thyroid Nodules: A Prospective Study of BRAF-Prevalent Population.
Thyroid Neoplasms
Infrequent activation of K-ras, H-ras, and other oncogenes in hepatocellular neoplasms initiated by methyl(acetoxymethyl)nitrosamine, a methylating agent, and promoted by phenobarbital in F344 rats.
Thyroid Neoplasms
Inhibition of malignant thyroid carcinoma cell proliferation by Ras and galectin-3 inhibitors.
Thyroid Neoplasms
Interaction between p53 and TGF beta 1 in control of epithelial cell proliferation.
Thyroid Neoplasms
Low frequency of TERT promoter mutations in a series of well-differentiated follicular-patterned thyroid neoplasms.
Thyroid Neoplasms
miR-206 inhibits thyroid cancer proliferation and invasion by targeting RAP1B.
Thyroid Neoplasms
miR-597-3p inhibits invasion and migration of thyroid carcinoma SW579 cell by targeting RAB23.
Thyroid Neoplasms
Rap2A Is Upregulated in Invasive Cells Dissected from Follicular Thyroid Cancer.
Thyroid Neoplasms
Rapid detection of K-, N-, H-RAS, and BRAF hotspot mutations in thyroid cancer using the multiplex primer extension.
Thyroid Neoplasms
ras mutations are associated with aggressive tumor phenotypes and poor prognosis in thyroid cancer.
Thyroid Neoplasms
Regulation of uptake of 18F-FDG by a follicular human thyroid cancer cell line with mutation-activated K-ras.
Thyroid Neoplasms
RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase.
Thyroid Neoplasms
Screening of specific changes in mRNAs in thyroid tumors by sequence specific differential display: decreased expression of c-fos mRNA in papillary carcinoma.
Thyroid Neoplasms
Upregulation of the PI3K/Akt pathway in the tumorigenesis of canine thyroid carcinoma.
Thyroid Nodule
American College of Radiology thyroid imaging report and data system combined with K-RAS mutation improves the management of cytologically indeterminate thyroid nodules.
Thyroid Nodule
Combination of ultrasound and molecular testing in malignancy risk estimate of Bethesda category IV thyroid nodules: results from a single-institution prospective study.
Thyroid Nodule
PCR amplification and analysis of ras oncogenes from thyroid cytologic smears.
Thyroid Nodule
RAS Mutations in AUS/FLUS Cytology: Does it Have an Additional Role in BRAFV600E Mutation-Negative Nodules?
Toxoplasmosis
Small GTPase Immunity-Associated Proteins Mediate Resistance to Toxoplasma gondii Infection in Lewis Rat.
Triple Negative Breast Neoplasms
A novel role for flotillin-1 in H-Ras-regulated breast cancer aggressiveness.
Triple Negative Breast Neoplasms
Loss of RAB1B promotes triple-negative breast cancer metastasis by activating TGF-?/SMAD signaling.
Triple Negative Breast Neoplasms
MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer.
Triple Negative Breast Neoplasms
MicroRNA-192-5p inhibits migration of triple negative breast cancer cells and directly regulates Rho GTPase activating protein 19.
Triple Negative Breast Neoplasms
Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway.
Triple Negative Breast Neoplasms
RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer.
Triple Negative Breast Neoplasms
Selective stabilization of multiple promoter G-quadruplex DNA by using 2-phenyl-1H-imidazole-based tanshinone IIA derivatives and their potential suppressing function in the metastatic breast cancer.
Triple Negative Breast Neoplasms
The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.
Triple Negative Breast Neoplasms
The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors.
Trophoblastic Neoplasms
Decreased expression of Ras GTPase activating protein in human trophoblastic tumors.
Tuberculosis
Antibodies against mycobacterial antigens in the synovial fluid of patients with temporomandibular disorders.
Tuberculosis
Cloning and sequence determination of the gene coding for the elongation factor Tu of Mycobacterium leprae.
Tuberculosis
Deviant expression of Rab5 on phagosomes containing the intracellular pathogens Mycobacterium tuberculosis and Legionella pneumophila is associated with altered phagosomal fate.
Tuberculosis
Formulation and Intracellular Trafficking of Lipid-Drug Conjugate Nanoparticles Containing a Hydrophilic Antitubercular Drug for Improved Intracellular Delivery to Human Macrophages.
Tuberculosis
Interaction of Mycobacterium tuberculosis Elongation Factor Tu with GTP is regulated by phosphorylation.
Tuberculosis
Mapping and identification of the major cell wall-associated components of Mycobacterium leprae.
Tuberculosis
Ras-associated small GTPase 33A, a novel T cell factor, is down-regulated in patients with tuberculosis.
Tuberous Sclerosis
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2.
Tuberous Sclerosis
Recent advances in the regulation of the TOR pathway by insulin and nutrients.
Tuberous Sclerosis
Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice.
Tuberous Sclerosis
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity.
Tuberous Sclerosis
Sequence-specific 1H, 13C, and 15N backbone assignment of the activated 21 kDa GTPase rRheb.
Tuberous Sclerosis
Sequence-specific 1H, 13C, and 15N backbone assignment of the GTPase rRheb in its GDP-bound form.
Tuberous Sclerosis
TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?
Tuberous Sclerosis
Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1.
tubulinyl-tyr carboxypeptidase deficiency
MAP1B regulates axonal development by modulating Rho-GTPase Rac1 activity.
Ureteral Obstruction
Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice.
Ureteral Obstruction
Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice.
Urinary Bladder Neoplasms
?-Lipoic acid suppresses migration and invasion via downregulation of cell surface ?1-integrin expression in bladder cancer cells.
Urinary Bladder Neoplasms
A method to quantitatively detect H-ras point mutation based on electrochemiluminescence.
Urinary Bladder Neoplasms
A PCR-RFLP method for the detection of activated H-ras oncogene with a point mutation at codon 12 and 61.
Urinary Bladder Neoplasms
A single nucleotide polymorphism in the human H-ras proto-oncogene determines the risk of urinary bladder cancer.
Urinary Bladder Neoplasms
Activated H-ras gene mutations in transitional cell carcinoma of urinary bladder in a Kashmiri population.
Urinary Bladder Neoplasms
Activation of H-ras oncogene in rat bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Urinary Bladder Neoplasms
Adenovirus-mediated gene therapy for bladder cancer in an orthotopic model using a dominant negative H-ras mutant.
Urinary Bladder Neoplasms
Analysis of p53, p16MTS, p21WAF1 and H-ras in archived bladder tumours from workers exposed to aromatic amines.
Urinary Bladder Neoplasms
Androgen Receptor Signaling Reduces the Efficacy of Bacillus Calmette-Guérin Therapy for Bladder Cancer via Modulating Rab27b-Induced Exocytosis.
Urinary Bladder Neoplasms
Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.
Urinary Bladder Neoplasms
Cell culture studies on the mechanism of action of chemical carcinogens and tumor promoters.
Urinary Bladder Neoplasms
Cellular disposal of miR23b by RAB27-dependent exosome release is linked to acquisition of metastatic properties.
Urinary Bladder Neoplasms
Clonal heterogeneity, experimental metastatic ability, and p21 expression in H-ras-transformed NIH 3T3 cells.
Urinary Bladder Neoplasms
Correction to: Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure.
Urinary Bladder Neoplasms
Correlation between the expression of the P21 ras oncogene product and the biological behavior of bladder tumors.
Urinary Bladder Neoplasms
Detection of altered H-ras proteins in human tumors using western blot analysis.
Urinary Bladder Neoplasms
Detection of H-ras gene point mutations in transitional cell carcinoma of human urinary bladder using polymerase chain reaction.
Urinary Bladder Neoplasms
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
Urinary Bladder Neoplasms
Frequency of H-ras mutations in human bladder cancer detected by direct sequencing.
Urinary Bladder Neoplasms
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in Kashmiri population.
Urinary Bladder Neoplasms
Genetic aberrations of the K-ras proto-oncogene in bladder cancer in relation to pesticide exposure.
Urinary Bladder Neoplasms
Genomic instability and loh at 2 polymorphic sites in the h-ras1 gene.
Urinary Bladder Neoplasms
H-ras activation and ras p21 expression in bladder tumors induced in F344/NCr rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Urinary Bladder Neoplasms
H-ras immunohistochemical expression and molecular analysis of urinary bladder lesions in grazing adult cattle exposed to bracken fern.
Urinary Bladder Neoplasms
H-ras mutation detection in bladder cancer by COLD-PCR analysis and direct sequencing.
Urinary Bladder Neoplasms
H-RAS mutation is a key molecular feature of pediatric urothelial bladder cancer. A detailed report of three cases.
Urinary Bladder Neoplasms
H-ras oncogene mutations in the urine of patients with bladder-tumors - description of a noninvasive method for the detection of neoplasia.
Urinary Bladder Neoplasms
H-RAS, K-RAS, and N-RAS gene activation in human bladder cancers.
Urinary Bladder Neoplasms
Identification of H-ras mutations in urine sediments complements cytology in the detection of bladder tumors.
Urinary Bladder Neoplasms
Inhibition of miR-1247 on cell proliferation and invasion in bladder cancer through its downstream target of RAB36.
Urinary Bladder Neoplasms
Introduction of wild-type p53 gene downregulates the expression of H-ras gene and suppresses the growth of bladder cancer cells.
Urinary Bladder Neoplasms
K-RAS mutation in transitional cell carcinoma of urinary bladder.
Urinary Bladder Neoplasms
Lack of p53 and ras mutations in Helicobacter hepaticus-induced liver tumors in A/JCr mice.
Urinary Bladder Neoplasms
LINC00319-Mediated miR-3127 Repression Enhances Bladder Cancer Progression Through Upregulation of RAP2A.
Urinary Bladder Neoplasms
Mechanisms of multistage chemical carcinogenesis and their relevance to respiratory tract cancer.
Urinary Bladder Neoplasms
microRNA-195 inhibits cell proliferation in bladder cancer via inhibition of cell division control protein 42 homolog/signal transducer and activator of transcription-3 signaling.
Urinary Bladder Neoplasms
MiR-381-3p/RAB2A axis activates cell proliferation and inhibits cell apoptosis in bladder cancer.
Urinary Bladder Neoplasms
Molecular mechanisms of tumor promotion and multistage carcinogenesis.
Urinary Bladder Neoplasms
Molecular pathways of urothelial development and bladder tumorigenesis.
Urinary Bladder Neoplasms
Mutation of H-ras is infrequent in bladder cancer: confirmation by single-strand conformation polymorphism analysis, designed restriction fragment length polymorphisms, and direct sequencing.
Urinary Bladder Neoplasms
Novel RasGRF1-derived Tat-fused peptides inhibiting Ras-dependent proliferation and migration in mouse and human cancer cells.
Urinary Bladder Neoplasms
Oncogenic activation of Pak1-dependent pathway of macropinocytosis determines BCG entry into bladder cancer cells.
Urinary Bladder Neoplasms
Oncogenic H-Ras, FK228, and exogenous H2O2 cooperatively activated the ERK pathway in selective induction of human urinary bladder cancer J82 cell death.
Urinary Bladder Neoplasms
Overexpression of RIN1 associates with tumor grade and progression in patients of bladder urothelial carcinoma.
Urinary Bladder Neoplasms
p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients.
Urinary Bladder Neoplasms
Phosphodiesterase 5 inhibitors enhance chemotherapy killing in gastrointestinal/genitourinary cancer cells.
Urinary Bladder Neoplasms
Polymorphic variants of H-RAS protooncogene and their possible role in bladder cancer etiology.
Urinary Bladder Neoplasms
Polymorphisms in DNA repair and metabolic genes in bladder cancer.
Urinary Bladder Neoplasms
Proapoptotic ability of oncogenic H-Ras to facilitate apoptosis induced by histone deacetylase inhibitors in human cancer cells.
Urinary Bladder Neoplasms
Rab11 Functions as an Oncoprotein via Nuclear Factor kappa B (NF-?B) Signaling Pathway in Human Bladder Carcinoma.
Urinary Bladder Neoplasms
Rab23 is overexpressed in human bladder cancer and promotes cancer cell proliferation and invasion.
Urinary Bladder Neoplasms
Rab27A overexpression promotes bladder cancer proliferation and chemoresistance through regulation of NF-?B signaling.
Urinary Bladder Neoplasms
RAB38 promotes bladder cancer growth by promoting cell proliferation and motility.
Urinary Bladder Neoplasms
Rac Family Small GTPase 3 Correlates with Progression and Poor Prognosis in Bladder Cancer.
Urinary Bladder Neoplasms
Radiation sensitization of human cancer cells in vivo by inhibiting the activity of PI3K using LY294002.
Urinary Bladder Neoplasms
Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.
Urinary Bladder Neoplasms
Reversibility of proliferative lesions and induction of non-papillary tumors in rat urinary bladder treated with phenylethyl isothiocyanate.
Urinary Bladder Neoplasms
RNA-interference-mediated Cdc42 silencing down-regulates phosphorylation of STAT3 and suppresses growth in human bladder-cancer cells.
Urinary Bladder Neoplasms
Role of reactive oxygen species in proapoptotic ability of oncogenic H-Ras to increase human bladder cancer cell susceptibility to histone deacetylase inhibitor for caspase induction.
Urinary Bladder Neoplasms
Screening of H-ras gene point mutations in 50 cases of bladder carcinoma.
Urinary Bladder Neoplasms
Screening of human bladder tumors and urine sediments for the presence of H-ras mutations.
Urinary Bladder Neoplasms
Significance of the Grb2 and son of sevenless (Sos) proteins in human bladder cancer cell lines.
Urinary Bladder Neoplasms
Some ras-transformed cells have increased radiosensitivity and decreased repair of sublethal radiation damage.
Urinary Bladder Neoplasms
Suppressive effects of dominant negative ras mutant N116Y on transformed phenotypes of human bladder cancer cells.
Urinary Bladder Neoplasms
The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.
Urinary Bladder Neoplasms
The long noncoding RNA KTN1-AS1 promotes bladder cancer tumorigenesis via KTN1 cis-activation and the consequent initiation of Rho GTPase-mediated signaling.
Urinary Bladder Neoplasms
The Ral GTPase pathway in metastatic bladder cancer: key mediator and therapeutic target.
Urinary Bladder Neoplasms
The role of Ras superfamily proteins in bladder cancer progression.
Urinary Bladder Neoplasms
Therapeutic efficacy of an adenovirus-mediated anti-H-ras ribozyme in experimental bladder cancer.
Urinary Bladder Neoplasms
Transcriptional activation of H-ras, K-ras and N-ras proto-oncogenes in human bladder tumors.
Urinary Bladder Neoplasms
UBIAD1 suppresses the proliferation of bladder carcinoma cells by regulating H-Ras intracellular trafficking via interaction with the C-terminal domain of H-Ras.
Urinary Bladder Neoplasms
Use of an anti-ras ribozyme to alter the malignant phenotype of a human bladder cancer cell line.
Urinary Bladder Neoplasms
Vascular endothelial growth factor, p53, and the H-ras oncogene in Egyptian patients with bladder cancer.
Urinary Retention
Urinary Retention, Incontinence, and Dysregulation of Muscarinic Receptors in Male Mice Lacking Mras.
Urologic Neoplasms
RhoA is associated with invasion and lymph node metastasis in upper urinary tract cancer.
Uterine Cervical Neoplasms
"Low-risk" and "high-risk" HPV-infection and K-ras gene point mutations in human cervical cancer: a study of 31 cases.
Uterine Cervical Neoplasms
Cdc42 expression in cervical cancer and its effects on cervical tumor invasion and migration.
Uterine Cervical Neoplasms
Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells.
Uterine Cervical Neoplasms
Genetic alterations in the K-Ras gene influence the prognosis in patients with cervical cancer treated by radiotherapy.
Uterine Cervical Neoplasms
Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin ?v?3/FAK/PI3K pathway-mediated Rac1 activation.
Uterine Cervical Neoplasms
METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
Uterine Cervical Neoplasms
Micro ribonucleic acid-93 promotes oncogenesis of cervical cancer by targeting RAB11 family interacting protein 1.
Uterine Cervical Neoplasms
MicroRNA-425 induces apoptosis and suppresses migration and invasion of human cervical cancer cells by targeting RAB2B.
Uterine Cervical Neoplasms
MicroRNA-720 promotes in vitro cell migration by targeting Rab35 expression in cervical cancer cells.
Uterine Cervical Neoplasms
MiR-29a inhibits cell proliferation and migration by targeting the CDC42/PAK1 signaling pathway in cervical cancer.
Uterine Cervical Neoplasms
Nuclear expression of Rac1 in cervical premalignant lesions and cervical cancer cells.
Uterine Cervical Neoplasms
Overexpression of ARHGAP30 suppresses growth of cervical cancer cells by downregulating ribosome biogenesis.
Uterine Cervical Neoplasms
Overexpression of the BRIP1 ameliorates chemosensitivity to cisplatin by inhibiting Rac1 GTPase activity in cervical carcinoma HeLa cells.
Uterine Cervical Neoplasms
Rac1 GTPase-deficient HeLa cells present reduced DNA repair, proliferation, and survival under UV or gamma irradiation.
Uterine Cervical Neoplasms
Radiation-induced increase in cell migration and metastatic potential of cervical cancer cells operates via the K-Ras pathway.
Uterine Cervical Neoplasms
Role of miR-337-3p and its target Rap1A in modulating proliferation, invasion, migration and apoptosis of cervical cancer cells.
Uterine Cervical Neoplasms
The effect of HMGB1 on the clinicopathological and prognostic features of cervical cancer.
Uterine Cervical Neoplasms
The relevance of oncogenes as prognostic markers in cervical cancer.
Uterine Cervical Neoplasms
The roles of Cdc42 and Rac1 in the formation of plasma membrane protrusions in cancer epithelial HeLa cells.
Uterine Cervical Neoplasms
Transcriptional activation of H- and N-ras oncogenes in human cervical cancer.
Uterine Cervical Neoplasms
[Analysis of prevalence of point mutations in codon 12 of oncogene K-ras from non-cancerous samples of cervical cytology positive for type 16 or 18 PVH]
Uterine Cervical Neoplasms
[Effect of Rab11 gene expression on the invasion and migration of cervical cancer cell line SiHa in hypoxia].
Uterine Cervical Neoplasms
[miR-143 inhibits cell proliferation through targeted regulating the expression of K-ras gene in HeLa cells].
Uterine Cervicitis
K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix.
Uterine Cervicitis
[Clinical significance of p21H-ras expression and H-ras codon 12 mutation in squamous intraepithelial lesion (SIL) and carcinoma of uterine cervix]
Uterine Neoplasms
K-ras mutations in lung tumors and tumors from other organs are consistent with a common mechanism of ethylene oxide tumorigenesis in the B6C3F1 mouse.
Vaccinia
A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization.
Vaccinia
A role for the small GTPase Rac1 in vaccinia actin-based motility.
Vaccinia
Association of Rap1a and Rap1b proteins with late endocytic/phagocytic compartments and Rap2a with the Golgi complex.
Vaccinia
Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells.
Vaccinia
Identification of a human CD8+ T lymphocyte neo-epitope created by a ras codon 12 mutation which is restricted by the HLA-A2 allele.
Vaccinia
Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.
Vaccinia
lncRNA UCA1-Mediated Cdc42 Signaling Promotes Oncolytic Vaccinia Virus Cell-to-Cell Spread in Ovarian Cancer.
Vaccinia
Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.
Vaccinia
The formin FHOD1 and the small GTPase Rac1 promote vaccinia virus actin-based motility.
Vascular Diseases
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Vascular Malformations
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression.
Vascular Malformations
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations.
Vascular System Injuries
Assessment of roles for the Rho-specific guanine nucleotide dissociation inhibitor (RhoGDI) Ly-GDI in platelet function: a spatial systems approach.
Vascular System Injuries
Endothelial Cdc42 deficiency impairs endothelial regeneration and vascular repair after inflammatory vascular injury.
Vascular System Injuries
Inhibitory effect of fluvastatin on aortic intimal thickening in normocholesterolemic rabbits.
Ventilator-Induced Lung Injury
Role of Krev Interaction Trapped-1 in Prostacyclin-Induced Protection against Lung Vascular Permeability Induced by Excessive Mechanical Forces and Thrombin Receptor Activating Peptide 6.
Vesicular Stomatitis
Directed membrane transport is involved in process formation in cultured podocytes.
Vesicular Stomatitis
Ganglioside GD3 traffics from the trans-Golgi network to plasma membrane by a Rab11-independent and brefeldin A-insensitive exocytic pathway.
Vesicular Stomatitis
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex.
Vesicular Stomatitis
H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status.
Vesicular Stomatitis
Identification and characterization of a novel broad spectrum virus entry inhibitor.
Vesicular Stomatitis
Phosphatidylinositol 3-phosphatase myotubularin-related protein 6 (MTMR6) is regulated by small GTPase Rab1B in the early secretory and autophagic pathways.
Vesicular Stomatitis
Phosphatidylinositol 4-kinasebeta is critical for functional association of rab11 with the Golgi complex.
Virus Diseases
Antiviral phagocytosis is regulated by a novel Rab-dependent complex in shrimp penaeus japonicus.
Virus Diseases
Characterization of a Rab GTPase up-regulated in the shrimp Peneaus japonicus by virus infection.
Virus Diseases
Disentangling the role of PI3K/Akt, Rho GTPase and the actin cytoskeleton on dengue virus infection.
Virus Diseases
Dissecting the role of a plant-specific Rab5 small GTPase NbRabF1 in Bamboo mosaic virus infection.
Virus Diseases
Efficient entry of budded virions of Autographa californica multiple nucleopolyhedrovirus into Spodoptera frugiperda cells is dependent on dynamin, Rab5, and Rab11.
Virus Diseases
Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport.
Virus Diseases
H-Ras Exerts Opposing Effects on Type I Interferon Responses Depending on Its Activation Status.
Virus Diseases
HIV signaling through CD4 and CCR5 activates Rho family GTPases that are required for optimal infection of primary CD4+ T cells.
Virus Diseases
Intracellular distribution and transcriptional regulation of Atlantic salmon (Salmo salar) Rab5c, 7a and 27a homologs by immune stimuli.
Virus Diseases
MIF inhibits monocytic movement through a non-canonical receptor and disruption of temporal Rho GTPase activities in U-937 cells.
Virus Diseases
NbRABG3f, a member of Rab GTPase, is involved in Bamboo mosaic virus infection in Nicotiana benthamiana.
Virus Diseases
Rab18 Facilitates Dengue Virus Infection by Targeting Fatty Acid Synthase to Sites of Viral Replication.
Virus Diseases
Rab27b regulates extracellular vesicle production in cells infected with Kaposi's sarcoma-associated herpesvirus to promote cell survival and persistent infection.
Virus Diseases
Rab5 and Rab11 Are Required for Clathrin-Dependent Endocytosis of Japanese Encephalitis Virus in BHK-21 Cells.
Virus Diseases
Rac1 and PAK1 are upstream of IKK-epsilon and TBK-1 in the viral activation of interferon regulatory factor-3.
Virus Diseases
Role of the small GTPase Rab27a during herpes simplex virus infection of oligodendrocytic cells.
Virus Diseases
Roles of small GTPase Rac1 in the regulation of actin cytoskeleton during dengue virus infection.
Virus Diseases
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Vision Disorders
ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.
Vitamin D Deficiency
K-ras mutations in 1,2-dimethylhydrazine-induced colonic tumors: effects of supplemental dietary calcium and vitamin D deficiency.
Vitiligo
Autoantigens in Vitiligo Identified by the Serological Selection of a Phage-Displayed Melanocyte cDNA Expression Library.
Vitiligo
Melanocyte Precursors in the Hair Follicle Bulge of Repigmented Vitiligo Skin Are Controlled by RHO-GTPase, KCTD10, and CTNNB1 Signaling.
von Hippel-Lindau Disease
Alterations of tumor suppressor genes and the H-ras oncogene in oral squamous cell carcinoma.
Wasting Syndrome
Reciprocal Regulation of Glycolysis-Driven Th17 Pathogenicity and Regulatory T Cell Stability by Cdc42.
Werner Syndrome
Contribution of Cdc42 to cholesterol efflux in fibroblasts from Tangier disease and Werner syndrome.
Werner Syndrome
Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase.
Whooping Cough
A link between Cdc42 and syntaxin is involved in mastoparan-stimulated insulin release.
Whooping Cough
Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.
Whooping Cough
Calcium mobilization and protease-activated receptor cleavage after thrombin stimulation in motor neurons.
Whooping Cough
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid.
Whooping Cough
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases.
Whooping Cough
Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositide-specific phospholipase C.
Whooping Cough
Effector function for RAS oncogene in interleukin-3-dependent myeloid cells involves diminished efficacy of prostaglandin E1-mediated inhibition of proliferation.
Whooping Cough
Endothelin 1 stimulates beta1Pix-dependent activation of Cdc42 through the G(salpha) pathway.
Whooping Cough
Erk1/2- and p38 MAP kinase-dependent phosphorylation and activation of cPLA2 by m3 and m2 receptors.
Whooping Cough
Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1.
Whooping Cough
KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA.
Whooping Cough
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 Pathway.
Whooping Cough
Regulation of Rac and Cdc42 pathways by G(i) during lysophosphatidic acid-induced cell spreading.
Whooping Cough
Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression.
Whooping Cough
Somatostatin activation of mitogen-activated protein kinase via somatostatin receptor 1 (SSTR1).
Whooping Cough
Somatostatin receptor 1 (SSTR1)-mediated inhibition of cell proliferation correlates with the activation of the MAP kinase cascade: role of the phosphotyrosine phosphatase SHP-2.
Whooping Cough
The G12/13-RhoA signaling pathway contributes to efficient lysophosphatidic acid-stimulated cell migration.
Whooping Cough
The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes.
Whooping Cough
Xaliproden (SR57746A) induces 5-HT1A receptor-mediated MAP kinase activation in PC12 cells.
Wilms Tumor
A Murine Model of K-RAS and ?-Catenin Induced Renal Tumors Expresses High Levels of E2F1 and Resembles Human Wilms Tumor.
Wilms Tumor
Co-deletions of the retinoblastoma gene and Wilms' tumor gene and rearrangement of the Krev-1 gene in a human insulinoma.
Wilms Tumor
Further studies on aberrant gene expression associated with arsenic-induced malignant transformation in rat liver TRL1215 cells.
Wilms Tumor
Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero.
Wiskott-Aldrich Syndrome
A conserved amphipathic helix in WASP/Scar proteins is essential for activation of Arp2/3 complex.
Wiskott-Aldrich Syndrome
A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.
Wiskott-Aldrich Syndrome
A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein.
Wiskott-Aldrich Syndrome
A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42.
Wiskott-Aldrich Syndrome
Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex.
Wiskott-Aldrich Syndrome
Activation of compensatory pathways via Rac2 in the absence of the Cdc42 effector Wiskott-Aldrich syndrome protein in Dendritic cells.
Wiskott-Aldrich Syndrome
AKAP350 interaction with cdc42 interacting protein 4 at the Golgi apparatus.
Wiskott-Aldrich Syndrome
An actin-based protrusion originating from a podosome-enriched region initiates macrophage fusion.
Wiskott-Aldrich Syndrome
An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins.
Wiskott-Aldrich Syndrome
ATP-binding cassette transporter-1 induces rearrangement of actin cytoskeletons possibly through Cdc42/N-WASP.
Wiskott-Aldrich Syndrome
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein.
Wiskott-Aldrich Syndrome
C(16)-Ceramide-induced F-actin Regulation Stimulates Mouse Embryonic Stem Cell Migration: Involvement of N-WASP/Cdc42/Arp2/3 complex and cofilin-1/?-actinin.
Wiskott-Aldrich Syndrome
Caenorhabditis elegans wsp-1 regulation of synaptic function at the neuromuscular junction.
Wiskott-Aldrich Syndrome
Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.
Wiskott-Aldrich Syndrome
Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension.
Wiskott-Aldrich Syndrome
Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover.
Wiskott-Aldrich Syndrome
Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity.
Wiskott-Aldrich Syndrome
Cdc42 Regulates Fc{gamma} Receptor-mediated Phagocytosis through the Activation and Phosphorylation of WASP and N-WASP.
Wiskott-Aldrich Syndrome
Cdc42, Rac1, and the Wiskott-Aldrich syndrome protein are involved in the cytoskeletal regulation of B lymphocytes.
Wiskott-Aldrich Syndrome
Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease.
Wiskott-Aldrich Syndrome
Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. Comparison of kinetic properties of Cdc42 binding to the Cdc42-interactive domains.
Wiskott-Aldrich Syndrome
Coiling phagocytosis of Borrelia burgdorferi by primary human macrophages is controlled by CDC42Hs and Rac1 and involves recruitment of Wiskott-Aldrich syndrome protein and Arp2/3 complex.
Wiskott-Aldrich Syndrome
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP.
Wiskott-Aldrich Syndrome
Contrasting cytoskeletal regulation of MHC class II peptide presentation by human B cells or dendritic cells.
Wiskott-Aldrich Syndrome
Dedicator of cytokinesis 8 interacts with talin and wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity.
Wiskott-Aldrich Syndrome
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansion.
Wiskott-Aldrich Syndrome
Determination of in Vivo Dissociation Constant, KD, of Cdc42-Effector Complexes in Live Mammalian Cells Using Single Wavelength Fluorescence Cross-correlation Spectroscopy.
Wiskott-Aldrich Syndrome
Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42.
Wiskott-Aldrich Syndrome
DOCK8 immune deficiency as a model for primary cytoskeletal dysfunction.
Wiskott-Aldrich Syndrome
EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane curvature-dependent actin polymerization.
Wiskott-Aldrich Syndrome
Essential role of neural Wiskott-Aldrich syndrome protein in neurite extension in PC12 cells and rat hippocampal primary culture cells.
Wiskott-Aldrich Syndrome
Exploring the mechanism of flexible biomolecular recognition with single molecule dynamics.
Wiskott-Aldrich Syndrome
FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation.
Wiskott-Aldrich Syndrome
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation.
Wiskott-Aldrich Syndrome
Ganoderiol A-enriched extract suppresses migration and adhesion of MDA-MB-231 cells by inhibiting FAK-SRC-paxillin cascade pathway.
Wiskott-Aldrich Syndrome
Genetically encoded photoswitching of actin assembly through the Cdc42-WASP-Arp2/3 complex pathway.
Wiskott-Aldrich Syndrome
Global disruption of the WASP autoinhibited structure on Cdc42 binding. Ligand displacement as a novel method for monitoring amide hydrogen exchange.
Wiskott-Aldrich Syndrome
Identification of host proteins involved in rickettsial invasion of tick cells.
Wiskott-Aldrich Syndrome
Insulin-increased prolactin gene expression requires actin treadmilling: potential role for p21 activated kinase.
Wiskott-Aldrich Syndrome
Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis.
Wiskott-Aldrich Syndrome
Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.
Wiskott-Aldrich Syndrome
Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling.
Wiskott-Aldrich Syndrome
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP.
Wiskott-Aldrich Syndrome
Lassa Virus Cell Entry via Dystroglycan Involves an Unusual Pathway of Macropinocytosis.
Wiskott-Aldrich Syndrome
Levels of Rabs and WAVE family proteins associated with translocation of GLUT4 to the cell surface in endometria from hyperinsulinemic PCOS women.
Wiskott-Aldrich Syndrome
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling.
Wiskott-Aldrich Syndrome
Mangiferin inhibits cell migration and invasion through Rac1/WAVE2 signalling in breast cancer.
Wiskott-Aldrich Syndrome
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.
Wiskott-Aldrich Syndrome
Mechanisms of host cell exit by the intracellular bacterium Chlamydia.
Wiskott-Aldrich Syndrome
Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages.
Wiskott-Aldrich Syndrome
miR-142-3p Reduces the Size, Migration, and Contractility of Endometrial and Endometriotic Stromal Cells by Targeting Integrin- and Rho GTPase-Related Pathways That Regulate Cytoskeletal Function.
Wiskott-Aldrich Syndrome
Morphology of the lamellipodium and organization of actin filaments at the leading edge of crawling cells.
Wiskott-Aldrich Syndrome
N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator.
Wiskott-Aldrich Syndrome
N-WASP regulates extension of filopodia and processes by oligodendrocyte progenitors, oligodendrocytes, and Schwann cells-implications for axon ensheathment at myelination.
Wiskott-Aldrich Syndrome
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway.
Wiskott-Aldrich Syndrome
Neural Wiskott-Aldrich syndrome protein is implicated in the actin-based motility of Shigella flexneri.
Wiskott-Aldrich Syndrome
Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9.
Wiskott-Aldrich Syndrome
Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinase.
Wiskott-Aldrich Syndrome
Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling.
Wiskott-Aldrich Syndrome
Platelet lamellipodium formation is not required for thrombus formation and stability.
Wiskott-Aldrich Syndrome
Profilin enhances Cdc42-induced nucleation of actin polymerization.
Wiskott-Aldrich Syndrome
Progressive decline of T and B cell numbers and function in a patient with CDC42 deficiency.
Wiskott-Aldrich Syndrome
Protein-tyrosine kinase and GTPase signals cooperate to phosphorylate and activate Wiskott-Aldrich syndrome protein (WASP)/neuronal WASP.
Wiskott-Aldrich Syndrome
Rapid Actions of Plasma Membrane Estrogen Receptors Regulate Motility of Mouse Embryonic Stem Cells through a Profilin-1/Cofilin-1-Directed Kinase Signaling Pathway.
Wiskott-Aldrich Syndrome
Rapid association of cytoskeletal remodeling proteins with the developing phagosomes of human neutrophils.
Wiskott-Aldrich Syndrome
Rapid WAVE dynamics in dendritic spines of cultured hippocampal neurons is mediated by actin polymerization.
Wiskott-Aldrich Syndrome
Rational design of genetically encoded fluorescence resonance energy transfer-based sensors of cellular Cdc42 signaling.
Wiskott-Aldrich Syndrome
Regulation of Cdc42 and its effectors in epithelial morphogenesis.
Wiskott-Aldrich Syndrome
Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization.
Wiskott-Aldrich Syndrome
Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages.
Wiskott-Aldrich Syndrome
Rho family GTPase Cdc42 is essential for the actin-based motility of Shigella in mammalian cells.
Wiskott-Aldrich Syndrome
Rho kinase collaborates with p21-activated kinase to regulate actin polymerization and contraction in airway smooth muscle.
Wiskott-Aldrich Syndrome
Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of ?-Tocotrienol on Mammary Cancer Cell Migration and Invasion.
Wiskott-Aldrich Syndrome
Roles of rho GTPases in intracellular transport and cellular transformation.
Wiskott-Aldrich Syndrome
Spatial control of actin-based motility through plasmalemmal PtdIns(4,5)P2-rich raft assemblies.
Wiskott-Aldrich Syndrome
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein.
Wiskott-Aldrich Syndrome
Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.
Wiskott-Aldrich Syndrome
The adapter protein CrkII regulates neuronal Wiskott-Aldrich syndrome protein, actin polymerization, and tension development during contractile stimulation of smooth muscle.
Wiskott-Aldrich Syndrome
The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.
Wiskott-Aldrich Syndrome
The Cdc42-selective GAP Rich regulates postsynaptic development and retrograde BMP transsynaptic signaling.
Wiskott-Aldrich Syndrome
The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation.
Wiskott-Aldrich Syndrome
The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.
Wiskott-Aldrich Syndrome
The dock-and-coalesce mechanism for the association of a WASP disordered region with the Cdc42 GTPase.
Wiskott-Aldrich Syndrome
The interaction between Cdc42 and WASP is required for SDF-1-induced T-lymphocyte chemotaxis.
Wiskott-Aldrich Syndrome
The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis.
Wiskott-Aldrich Syndrome
The mechanism of CSF-1-induced Wiskott-Aldrich syndrome protein activation in vivo: a role for phosphatidylinositol 3-kinase and Cdc42.
Wiskott-Aldrich Syndrome
The nucleotide switch in Cdc42 modulates coupling between the GTPase-binding and allosteric equilibria of Wiskott-Aldrich syndrome protein.
Wiskott-Aldrich Syndrome
The Rho GTPase Cdc42 Is Essential for the Activation and Function of Mature B Cells.
Wiskott-Aldrich Syndrome
The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis.
Wiskott-Aldrich Syndrome
The small GTPase Cdc42 modulates the number of exocytosis-competent dense-core vesicles in PC12 cells.
Wiskott-Aldrich Syndrome
The small GTPase Cdc42 regulates actin polymerization and tension development during contractile stimulation of smooth muscle.
Wiskott-Aldrich Syndrome
The type III TGF? receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
Wiskott-Aldrich Syndrome
Thromboxane-induced actin polymerization in hypoxic neonatal pulmonary arterial myocytes involves Cdc42 signaling.
Wiskott-Aldrich Syndrome
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome.
Wiskott-Aldrich Syndrome
Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils.
Wiskott-Aldrich Syndrome
Tyrosine phosphorylation of the Wiskott-Aldrich syndrome protein by Lyn and Btk is regulated by CDC42.
Wiskott-Aldrich Syndrome
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility.
Wiskott-Aldrich Syndrome
WIP participates in actin reorganization and ruffle formation induced by PDGF.
Wiskott-Aldrich Syndrome
Wiskott-Aldrich syndrome protein (WASp) and N-WASp are involved in the regulation of NK-cell migration upon NKG2D activation.
Wiskott-Aldrich Syndrome
Wiskott-Aldrich syndrome protein induces actin clustering without direct binding to Cdc42.
Wiskott-Aldrich Syndrome
Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization.
Wiskott-Aldrich Syndrome
Yersinia enterocolitica invasin triggers phagocytosis via beta1 integrins, CDC42Hs and WASp in macrophages.
Zika Virus Infection
The small GTPase RAB1B promotes antiviral innate immunity by interacting with TNF receptor-associated factor 3 (TRAF3).
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
cell adhesion and migration are regulated through the concerted action of cytoskeletal dynamics and adhesion proteins, the activity of which is governed by RhoGTPases. Specific RhoGTPase signaling requires spatio-temporal activation and coordination of subsequent protein-protein and protein-lipid interactions. The nature, location and duration of these interactions are dependent on polarized extracellular triggers, such as cell-cell contact, and intracellular modifying events, such as phosphorylation. RhoA, RhoB, and RhoC are highly homologous GTPases that, however, succeed in generating specific intracellular responses
additional information
additional information
Rho GTPase structure-function analysis, comparisons of RhoA, RhoB, and RhoC enzymes, overview. Multiple regions in RhoA/B/C cooperate to provide specificity in binding to regulators and effectors. These specific interactions are highly regulated in time and space. Visualization and analyzsis of localized GTPase activation using biosensors that allow imaging of isoform-specific, localized regulation
additional information
Rho GTPase structure-function analysis, comparisons of RhoA, RhoB, and RhoC enzymes, overview. Multiple regions in RhoA/B/C cooperate to provide specificity in binding to regulators and effectors. These specific interactions are highly regulated in time and space. Visualization and analyzsis of localized GTPase activation using biosensors that allow imaging of isoform-specific, localized regulation
additional information
Rho GTPase structure-function analysis, comparisons of RhoA, RhoB, and RhoC enzymes, overview. Multiple regions in RhoA/B/C cooperate to provide specificity in binding to regulators and effectors. These specific interactions are highly regulated in time and space. Visualization and analyzsis of localized GTPase activation using biosensors that allow imaging of isoform-specific, localized regulation
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). RHOC_HUMAN
193
0
22006
Swiss-Prot
other Location (Reliability: 5)
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
structural core of RhoGTPases: the G domain, the Rho insert region, and the C-terminus of RhoGTPases, structure analysis, detailed overview. The hypervariable region also functions as protein binding site and determines, at least in part, specific binding to regulatory or effector proteins. In most RhoGTPases, including RhoA and RhoC, this region of around 10 residues harbors a polybasic stretch that binds the inner leaflet of the plasma membrane. RhoA, RhoB and RhoC have a very similar structure of the G domain and the insert region
additional information
structural core of RhoGTPases: the G domain, the Rho insert region, and the C-terminus of RhoGTPases, structure analysis, detailed overview. The hypervariable region also functions as protein binding site and determines, at least in part, specific binding to regulatory or effector proteins. In most RhoGTPases, including RhoA and RhoC, this region of around 10 residues harbors a polybasic stretch that binds the inner leaflet of the plasma membrane. RhoA, RhoB and RhoC have a very similar structure of the G domain and the insert region
additional information
structural core of RhoGTPases: the G domain, the Rho insert region, and the C-terminus of RhoGTPases, structure analysis, detailed overview. The hypervariable region also functions as protein binding site and determines, at least in part, specific binding to regulatory or effector proteins. In most RhoGTPases, including RhoA and RhoC, this region of around 10 residues harbors a polybasic stretch that binds the inner leaflet of the plasma membrane. RhoA, RhoB and RhoC have a very similar structure of the G domain and the insert region
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POSTTRANSLATIONAL MODIFICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
lipoprotein
the C-terminus of RhoGTPases comprises, next to the hypervariable region, the CAAX-box to which a lipid anchor is attached allowing GTPase binding to membranes. RhoA, RhoB and RhoC differ in this posttranslational lipid modification which has consequences for their subcellular localization. The lipid anchor regulates the interaction with RhoGDIs and with regions within the plasma membrane (RhoA, RhoC) or endosomal vesicles (RhoB). RhoA and RhoC are geranylgeranylated, whereas RhoB has both a palmitoyl anchor and a farnesyl or geranylgeranyl group
phosphoprotein
RhoC, but not RhoA, is phosphorylated on Ser73 in the alpha2-helix by the kinase Akt in SUM149 breast cancer cells54 although Ser73 is highly conserved among all 3 Rho-isoforms. Intriguingly, phosphorylation of RhoC is required for downstream signaling and invasiveness, which contrasts markedly with the inactivating phosphorylation at Ser188 in RhoA
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schaefer, A.; Reinhard, N.R.; Hordijk, P.L.
Toward understanding RhoGTPase specificity: structure, function and local activation
Small GTPases
5
6
2014
Homo sapiens (P08134), Homo sapiens (P61586), Homo sapiens (P62745)
brenda
EXTERNAL LINKS (specific for EC-Number 3.6.5.2)
Transporter Classification Database (TCDB): 8.A.92.1.15, 9.A.3.1.1
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Release 2023.1 (January 2023)
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