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Information on EC 3.6.1.15 - nucleoside-triphosphate phosphatase and Organism(s) Saccharolobus solfataricus and UniProt Accession Q97ZJ7

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IUBMB Comments
The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin .
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Saccharolobus solfataricus
UNIPROT: Q97ZJ7
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Word Map
The taxonomic range for the selected organisms is: Saccharolobus solfataricus
The enzyme appears in selected viruses and cellular organisms
Synonyms
ntpase, ntpdase, nucleoside triphosphatase, ntpdase1, ntpdase2, nsp13, kidins220, nucleoside triphosphate diphosphohydrolase, nucleoside triphosphate hydrolase, pvx cp, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
GP086L protein
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M86L protein
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MC100R
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NTPase
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nucleoside 5-triphosphatase
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nucleoside triphosphate phosphohydrolase
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nucleoside-5-triphosphate phosphohydrolase
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phosphatase, nucleoside tri-
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additional information
Sso0909 is an AAA protein
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of phosphoric ester
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
unspecific diphosphate phosphohydrolase
The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria. Also hydrolyses nucleoside diphosphates, thiamine diphosphate and FAD. The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin [5].
CAS REGISTRY NUMBER
COMMENTARY hide
9075-51-8
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
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?
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + H2O
ADP + phosphate
show the reaction diagram
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?
additional information
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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the ATPase domain of Cdc6-3, although having lost much of its DNA-binding activity from the origin, inhibits both Cdc6-1 and Cdc6-2
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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the ATPase domain of Cdc6-2 retains to a great extent the origin DNA-binding activity, and likewise maintains its stimulating effect on Cdc6-3, the ATPase domain of Cdc6-1, which also stimulated the DNA-binding ability of Cdc6-3
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene sso0909
UniProt
Manually annotated by BRENDA team
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant GST-tagged Sso0909 from Escherichia coli by glutathione affinity chromatography and gel filtration, recombinant His10-tagged Sso0909 from Sulfolobus solfataricus by nickel affinity chromatography and gel filtration to homogeneity
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene sso0909, DNA and amino acid sequence determination and analysis, expression analysis, sequence comparisons, phylogenetic analysis, overview. Expression of GST-tagged Sso0909 in Escherichia coli, overexpression of His10-tagged Sso0909 in Sulfolobus solfataricus
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
He, Z.G.; Feng, Y.; Wang, J.; Jiang, P.X.
The regulatory function of N-terminal AAA+ ATPase domain of eukaryote-like archaeal Orc1/Cdc6 protein during DNA replication initiation
Arch. Biochem. Biophys.
471
176-183
2008
Saccharolobus solfataricus
Manually annotated by BRENDA team
Hobel, C.F.; Albers, S.V.; Driessen, A.J.; Lupas, A.N.
The Sulfolobus solfataricus AAA protein Sso0909, a homologue of the eukaryotic ESCRT Vps4 ATPase
Biochem. Soc. Trans.
36
94-98
2008
Saccharolobus solfataricus (Q97ZJ7), Saccharolobus solfataricus
Manually annotated by BRENDA team