The enzyme, isolated from the bacterium Acidovorax citrulli, performs the deamination of melamine 15-fold faster than the deamination of ammeline. It also has activity with 2-chloro-4,6-diamino-s-triazine, but has no activity toward halo-substituted triazine ring compounds such as atrazine (cf. EC 3.8.1.8, atrazine chlorohydrolase).
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SYSTEMATIC NAME
IUBMB Comments
melamine aminohydrolase
The enzyme, isolated from the bacterium Acidovorax citrulli, performs the deamination of melamine 15-fold faster than the deamination of ammeline. It also has activity with 2-chloro-4,6-diamino-s-triazine, but has no activity toward halo-substituted triazine ring compounds such as atrazine (cf. EC 3.8.1.8, atrazine chlorohydrolase).
melamine deaminase has no detectable activity with the halo-triazine substrates. Melamine deaminase is active in deamination of a substrate that is structurally identical to atrazine, except for the substitution of an amino agroup for the chlorine atom. No substrates: ammelide, atrazine, desethylatrazine, desisopropylatrazine, cyromazine, fluoroatrazine, azidoatrazine, atratone, cyanoatrazine, 2,4,6-triaminopyrimidine, 2-amino-4,6-dichloropyrimidine, 6-chloro-2,4-diaminopyrimidine
melamine deaminase has no detectable activity with the halo-triazine substrates. Melamine deaminase is active in deamination of a substrate that is structurally identical to atrazine, except for the substitution of an amino agroup for the chlorine atom. No substrates: ammelide, atrazine, desethylatrazine, desisopropylatrazine, cyromazine, fluoroatrazine, azidoatrazine, atratone, cyanoatrazine, 2,4,6-triaminopyrimidine, 2-amino-4,6-dichloropyrimidine, 6-chloro-2,4-diaminopyrimidine
melamine deaminase TriA catalyzes deamination of 2-chloro-4,6-diamino-s-triazine to produce 2-chloro-4-amino-6-hydroxy-s-triazine, which undergoes dechlorination via hydroxyatrazine ethylaminohydrolase AtzB to yield ammelide
melamine deaminase TriA catalyzes deamination of 2-chloro-4,6-diamino-s-triazine to produce 2-chloro-4-amino-6-hydroxy-s-triazine, which undergoes dechlorination via hydroxyatrazine ethylaminohydrolase AtzB to yield ammelide
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History
Enzyme Nomenclature
3.5.4.45 melamine deaminase
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