Disease on EC 3.5.4.1 - cytosine deaminase
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Acquired Immunodeficiency Syndrome
A new approach to an AIDS vaccine: creating antibodies to HIV vif will enable apobec3G to turn HIV-infection into a benign problem.
Acquired Immunodeficiency Syndrome
An Alu Element Insertion in Intron 1 Results in Aberrant Alternative Splicing of APOBEC3G Pre-mRNA in Northern Pig-Tailed Macaques (Macaca leonina) That May Reduce APOBEC3G-Mediated Hypermutation Pressure on HIV-1.
Acquired Immunodeficiency Syndrome
APOBEC3-Mediated Editing in HIV Type 1 from Pediatric Patients and Its Association with APOBEC3G/CUL5 Polymorphisms and Vif Variability.
Acquired Immunodeficiency Syndrome
APOBEC3G genetic variants and their influence on the progression to AIDS.
Acquired Immunodeficiency Syndrome
APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate Host.
Acquired Immunodeficiency Syndrome
APOBEC3G Variants and Protection against HIV-1 Infection in Burkina Faso.
Acquired Immunodeficiency Syndrome
Association of single nucleotide polymorphisms of APOBEC3G with susceptibility to HIV-1 infection and disease progression among men engaging in homosexual activity in northern China.
Acquired Immunodeficiency Syndrome
Effect of HIV-1 Vif variability on progression to pediatric AIDS and its association with APOBEC3G and CUL5 polymorphisms.
Acquired Immunodeficiency Syndrome
Increased APOBEC3G and APOBEC3F expression is associated with low viral load and prolonged survival in simian immunodeficiency virus infected rhesus monkeys.
Acquired Immunodeficiency Syndrome
Inhibition of HIV-1 replication by simian restriction factors, TRIM5alpha and APOBEC3G.
Acquired Immunodeficiency Syndrome
Leveraging APOBEC3 proteins to alter the HIV mutation rate and combat AIDS.
Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G.
Acquired Immunodeficiency Syndrome
The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present.
Acquired Immunodeficiency Syndrome
Vif hijacks CBF-? to degrade APOBEC3G and promote HIV-1 infection.
Adenocarcinoma
5-Fluorocytosine-induced eradication of murine adenocarcinomas engineered to express the cytosine deaminase suicide gene requires host immune competence and leaves an efficient memory.
Adenocarcinoma
Anti-proliferative Effect of Engineered Neural Stem Cells Expressing Cytosine Deaminase and Interferon-? Against Lymph Node-derived Metastatic Colorectal Adenocarcinoma in Cellular and Xenograft Mouse Models.
Adenocarcinoma
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Adenocarcinoma
Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer.
Adenocarcinoma
The immune response elicited by mammary adenocarcinoma cells transduced with interferon-gamma and cytosine deaminase genes cures lung metastases by parental cells.
Adenocarcinoma
The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.
Adenocarcinoma
Treatment of human tumor cells by combine gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and bacterial cytosine deaminase suicide gene.
Adenocarcinoma
Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.
Adenocarcinoma of Lung
APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.
Adenocarcinoma of Lung
Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma.
Anemia
Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism.
Anemia
Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity.
Anemia
Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases.
Anemia
Role of cullin-elonginB-elonginC E3 complex in bovine immunodeficiency virus and maedi-visna virus Vif-mediated degradation of host A3Z2-Z3 proteins.
Arthritis
Small ruminant lentiviral Vif proteins commonly utilize cyclophilin A, an evolutionarily and structurally conserved protein, to degrade ovine and caprine APOBEC3 proteins.
Atherosclerosis
Epac1 (Exchange Protein Directly Activated by cAMP 1) Upregulates LOX-1 (Oxidized Low-Density Lipoprotein Receptor 1) to Promote Foam Cell Formation and Atherosclerosis Development.
Atherosclerosis
Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.
Atherosclerosis
High-resolution genetic mapping in the diversity outbred mouse population identifies Apobec1 as a candidate gene for atherosclerosis.
Barrett Esophagus
The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.
Brain Neoplasms
Adenosine potentiates the therapeutic effects of neural stem cells expressing cytosine deaminase against metastatic brain tumors.
Brain Neoplasms
Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties.
Brain Neoplasms
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Brain Neoplasms
Combined radiation and gene therapy for brain tumors with adenovirus-mediated transfer of cytosine deaminase and uracil phosphoribosyltransferase genes.
Brain Neoplasms
Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors.
Brain Neoplasms
Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine.
Brain Neoplasms
Human neural stem cells can target and deliver therapeutic genes to breast cancer brain metastases.
Brain Neoplasms
In vivo efficacy and toxicity of 5-fluorocytosine/cytosine deaminase gene therapy for malignant gliomas mediated by adenovirus.
Brain Neoplasms
Retrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells.
Brain Neoplasms
Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells.
Brain Neoplasms
The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase.
Brain Neoplasms
Transduction of cytosine deaminase gene makes rat glioma cells highly sensitive to 5-fluorocytosine.
Brain Neoplasms
Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy.
Brain Neoplasms
[Antineoplastic effect of 5-fluorocytosine and cytosine deaminase on brain tumor (author's transl)]
Breast Neoplasms
207 engineered human amniotic fluid-derived stem cells by expressing Cytosine deaminase (cd) and thymidine kinase (hsv-tk) mediate targeting killing effect in breast cancer cells.
Breast Neoplasms
Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Breast Neoplasms
Analysis of functional germline variants in APOBEC3 and driver genes on breast cancer risk in Moroccan study population.
Breast Neoplasms
Antitumor immune response induced by i.t. injection of vector-activated dendritic cells and chemotherapy suppresses metastatic breast cancer.
Breast Neoplasms
APOBEC3 Deletion is Associated with Breast Cancer Risk in a Sample of Southeast Iranian Population.
Breast Neoplasms
APOBEC3 deletion polymorphism is associated with breast cancer risk among women of European ancestry.
Breast Neoplasms
APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.
Breast Neoplasms
APOBEC3 enzymes mediate efficacy of cisplatin and are epistatic with base excision repair and mismatch repair in platinum response.
Breast Neoplasms
APOBEC3B expression in breast cancer cell lines and tumors depends on the estrogen receptor status.
Breast Neoplasms
Association of APOBEC3 deletion with cancer risk: A meta-analysis of 26 225 cases and 37 201 controls.
Breast Neoplasms
Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells.
Breast Neoplasms
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Breast Neoplasms
Connexin-43 Enhances the Redesigned Cytosine Deaminase Activity for Suicide Gene Therapy in Human Breast Cancer Cells.
Breast Neoplasms
Cytosine deaminase adenoviral vector and 5-fluorocytosine selectively reduce breast cancer cells 1 million-fold when they contaminate hematopoietic cells: a potential purging method for autologous transplantation.
Breast Neoplasms
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.
Breast Neoplasms
Efficient and nontoxic adenoviral purging method for autologous transplantation in breast cancer patients.
Breast Neoplasms
Elevated APOBEC3B correlates with poor outcomes for estrogen-receptor-positive breast cancers.
Breast Neoplasms
Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increases the infectivity and therapeutic effect for breast cancer gene therapy.
Breast Neoplasms
Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase.
Breast Neoplasms
Ex vivo breast cancer cell purging by adenovirus-mediated cytosine deaminase gene transfer and short-term incubation with 5-fluorocytosine completely prevents tumor growth after transplantation.
Breast Neoplasms
Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression.
Breast Neoplasms
Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models.
Breast Neoplasms
Inhibition of the aberrant A1CF-FAM224A-miR-590-3p-ZNF143 positive feedback loop attenuated malignant biological behaviors of glioma cells.
Breast Neoplasms
Intratumoral gene transfer of the Cytosine deaminase gene for the treatment of breast cancer.
Breast Neoplasms
iPS-derived MSCs from an expandable bank to deliver a prodrug-converting enzyme that limits growth and metastases of human breast cancers.
Breast Neoplasms
Nanoplex Delivery of siRNA and Prodrug Enzyme for Multimodality Image-Guided Molecular Pathway Targeted Cancer Therapy.
Breast Neoplasms
Non-viral Suicide Gene Therapy: Cytosine Deaminase Gene Directed by VEGF Promoter and 5-fluorocytosine as a Gene Directed Enzyme/prodrug System in Breast Cancer Model.
Breast Neoplasms
Novel cytosine deaminase fusion gene enhances the effect of radiation on breast cancer in bone by reducing tumor burden, osteolysis, and skeletal fracture.
Breast Neoplasms
Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.
Breast Neoplasms
Selective antitumor effect of neural stem cells expressing cytosine deaminase and interferon-beta against ductal breast cancer cells in cellular and xenograft models.
Breast Neoplasms
Synergistic effect of therapeutic stem cells expressing cytosine deaminase and interferon-beta via apoptotic pathway in the metastatic mouse model of breast cancer.
Breast Neoplasms
The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer.
Breast Neoplasms
Thymidine kinase/ganciclovir and cytosine deaminase/5-fluorocytosine suicide gene therapy-induced cell apoptosis in breast cancer cells.
Carcinogenesis
APOBEC-mediated DNA alterations: A possible new mechanism of carcinogenesis in EBV-positive gastric cancer.
Carcinogenesis
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis.
Carcinogenesis
Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression.
Carcinogenesis
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.
Carcinogenesis
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.
Carcinogenesis
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Carcinogenesis
HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples.
Carcinogenesis
Hypermutation in the E2 gene of human papillomavirus type 16 in cervical intraepithelial neoplasia.
Carcinogenesis
Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA.
Carcinogenesis
Phosphorylation Directly Regulates the Intrinsic DNA Cytidine Deaminase Activity of Activation-induced Deaminase and APOBEC3G Protein.
Carcinogenesis
Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3B.
Carcinogenesis
The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.
Carcinogenesis
The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.
Carcinogenesis
Understanding the regulation of APOBEC3 expression: Current evidence and much to learn.
Carcinoma
A33scFv-cytosine deaminase: a recombinant protein construct for antibody-directed enzyme-prodrug therapy.
Carcinoma
Activation of the CMV-IE promoter by hyperthermia in vitro and in vivo: biphasic heat induction of cytosine deaminase suicide gene expression.
Carcinoma
Adenovirus-mediated lymphotactin gene transfer improves therapeutic efficacy of cytosine deaminase suicide gene therapy in established murine colon carcinoma.
Carcinoma
Adenovirus-mediated tissue-targeted expression of the CDglyTk gene for the treatment of breast cancer.
Carcinoma
Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia.
Carcinoma
APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells.
Carcinoma
APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression.
Carcinoma
APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma.
Carcinoma
APOBEC3G expression is correlated with poor prognosis in colon carcinoma patients with hepatic metastasis.
Carcinoma
Combined treatment, based on lysomustine administration with mesenchymal stem cells expressing cytosine deaminase therapy, leads to pronounced murine Lewis lung carcinoma growth inhibition.
Carcinoma
Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.
Carcinoma
Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model.
Carcinoma
Effective antitumoral immune responses are not induced by cytosine deaminase suicide gene transfer in a syngeneic rat pancreatic carcinoma model.
Carcinoma
Enhanced killing of ovarian carcinoma using oncolytic measles vaccine virus armed with a yeast cytosine deaminase and uracil phosphoribosyltransferase.
Carcinoma
Expression of Cytosine Deaminase Gene in Human Colon Carcinoma Cells by Recombinant Retroviral Vector.
Carcinoma
Gene therapy of metastatic colon carcinoma: regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase.
Carcinoma
Genetic immunotherapy for hepatocellular carcinoma by endothelial progenitor cells armed with cytosine deaminase.
Carcinoma
In vitro and in vivo effect of 5-FC combined gene therapy with TNF-? and CD suicide gene on human laryngeal carcinoma cell line Hep-2.
Carcinoma
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.
Carcinoma
Inhibitory effect of therapeutic genes, cytosine deaminase and interferon??, delivered by genetically engineered stem cells against renal cell carcinoma.
Carcinoma
Long non-coding RNA ESCCAL-1 promotes esophageal squamous cell carcinoma by down regulating the negative regulator of APOBEC3G.
Carcinoma
Nonviral jet-injection gene transfer for efficient in vivo cytosine deaminase suicide gene therapy of colon carcinoma.
Carcinoma
Oncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma.
Carcinoma
Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene.
Carcinoma
Phase I study of direct administration of a replication deficient adenovirus vector containing the E. coli cytosine deaminase gene to metastatic colon carcinoma of the liver in association with the oral administration of the pro-drug 5-fluorocytosine.
Carcinoma
PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas.
Carcinoma
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Carcinoma
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma.
Carcinoma
Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.
Carcinoma
Systemic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice.
Carcinoma
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes.
Carcinoma
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.
Carcinoma
[Anticancer efficacy of combining cytosine deaminase/5-fluorocytosine gene therapy and radiotherapy on cervical carcinoma]
Carcinoma
[Experimental study on human pancreatic carcinoma treated by cytosine deaminase gene therapy]
Carcinoma
[The killing effects of two prodrug sensitivity genes on human pancreatic carcinoma cells PC-2]
Carcinoma, Adenoid Cystic
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Carcinoma, Ductal
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Carcinoma, Hepatocellular
A double suicide gene system driven by vascular endothelial growth factor promoter selectively kills human hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Adenovirus-mediated tissue-specific cytosine deaminase gene therapy for human hepatocellular carcinoma with different AFP expression levels.
Carcinoma, Hepatocellular
APOBEC3G exerts tumor suppressive effects in human hepatocellular carcinoma.
Carcinoma, Hepatocellular
Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.
Carcinoma, Hepatocellular
Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model.
Carcinoma, Hepatocellular
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Carcinoma, Hepatocellular
Correlation of APOBEC3 in tumor tissues with clinico-pathological features and survival from hepatocellular carcinoma after curative hepatectomy.
Carcinoma, Hepatocellular
Cytosine deaminase/5-fluorocytosine gene therapy can induce efficient anti-tumor effects and protective immunity in immunocompetent mice but not in athymic nude mice.
Carcinoma, Hepatocellular
Cytotoxic effect of a replication-incompetent adenoviral vector with cytosine deaminase gene driven by L-plastin promoter in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
DHX9 interacts with APOBEC3B and attenuates the anti-HBV effect of APOBEC3B.
Carcinoma, Hepatocellular
Endothelial Progenitor Cells Combined with Cytosine Deaminase-Endostatin for Suppression of Liver Carcinoma.
Carcinoma, Hepatocellular
Fusion of HSV-1 VP22 to a bifunctional chimeric SuperCD suicide gene compensates for low suicide gene transduction efficiencies.
Carcinoma, Hepatocellular
Gene therapy for human hepatocellular carcinoma with cytosine deaminase gene and prodrug flucytosine.
Carcinoma, Hepatocellular
Gene Therapy with Cytosine Deaminase and Endostatin Fusion Gene Mediated by Endothelial Progenitor Cells in Hepatomas.
Carcinoma, Hepatocellular
Genetic immunotherapy for hepatocellular carcinoma by endothelial progenitor cells armed with cytosine deaminase.
Carcinoma, Hepatocellular
Genetic Polymorphisms Predisposing the Interleukin 6-Induced APOBEC3B-UNG Imbalance Increase HCC Risk via Promoting the Generation of APOBEC-Signature HBV Mutations.
Carcinoma, Hepatocellular
High expression of APOBEC3G in patients infected with hepatitis C virus.
Carcinoma, Hepatocellular
Human Sulfatase-1 Improves the Effectiveness of Cytosine Deaminase Suicide Gene Therapy with 5-Fluorocytosine Treatment on Hepatocellular Carcinoma Cell Line HepG2 In Vitro and In Vivo.
Carcinoma, Hepatocellular
In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene.
Carcinoma, Hepatocellular
Inhibition of hepatitis B virus replication by APOBEC3G in vitro and in vivo.
Carcinoma, Hepatocellular
N-terminal and C-terminal cytosine deaminase domain of APOBEC3G inhibit hepatitis B virus replication.
Carcinoma, Hepatocellular
Non-lytic Lymphocytes Engineered to Express Virus-specific T-cell Receptors Limit HBV Infection by Activating APOBEC3.
Carcinoma, Hepatocellular
Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-related hepatocellular carcinoma.
Carcinoma, Hepatocellular
Preclinical evaluation of transcriptional targeting strategy for human hepatocellular carcinoma in an orthotopic xenograft mouse model.
Carcinoma, Hepatocellular
Protein transduction with bacterial cytosine deaminase fused to the TLM intercellular transport motif induces profound chemosensitivity to 5-fluorocytosine in human hepatoma cells.
Carcinoma, Hepatocellular
The RNA-editing enzyme APOBEC1 requires heterogeneous nuclear ribonucleoprotein Q isoform 6 for efficient interaction with interleukin-8 mRNA.
Carcinoma, Hepatocellular
[Expression and subcellular localization of APOBEC3G in peripheral blood mononuclear cells and liver tissues of chronic HBV patients]
Carcinoma, Intraductal, Noninfiltrating
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Carcinoma, Lewis Lung
Combined treatment, based on lysomustine administration with mesenchymal stem cells expressing cytosine deaminase therapy, leads to pronounced murine Lewis lung carcinoma growth inhibition.
Carcinoma, Non-Small-Cell Lung
Associations of cytosine deaminase gene polymorphisms with effectiveness of gemcitabine/cisplatin chemotherapy in patients of Xinjiang Uyghur and Han nationality with non-small cell lung cancer.
Carcinoma, Ovarian Epithelial
APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.
Carcinoma, Renal Cell
APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells.
Carcinoma, Renal Cell
Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model.
Carcinoma, Renal Cell
Inhibitory effect of therapeutic genes, cytosine deaminase and interferon??, delivered by genetically engineered stem cells against renal cell carcinoma.
Carcinoma, Squamous Cell
Oncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma.
Carcinoma, Squamous Cell
PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas.
Carcinoma, Squamous Cell
Therapeutic effect of AdCMVCD/5-FC system and metabolism of 5-FC in the treatment of human tongue squamous cell carcinoma.
Carcinoma, Squamous Cell
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.
Cervical Intraepithelial Neoplasia
APOBEC3G is increasingly expressed on the human uterine cervical intraepithelial neoplasia along with disease progression.
Cervical Intraepithelial Neoplasia
Correlation of APOBEC3G Polymorphism with Human Papillomavirus (HPV) Persistent Infection and Progression of Cervical Lesions.
Cholangiocarcinoma
Combined cytosine deaminase expression, 5-fluorocytosine exposure, and radiotherapy increases cytotoxicity to cholangiocarcinoma cells.
Cholangiocarcinoma
Fractionated radiation therapy in combination with adenoviral delivery of the cytosine deaminase gene and 5-fluorocytosine enhances cytotoxic and antitumor effects in human colorectal and cholangiocarcinoma models.
Cholelithiasis
Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease.
Choriocarcinoma
Cancer-Specific Inhibitory Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-? Against Choriocarcinoma in Xenografted Metastatic Mouse Models.
Coinfection
HBV/HIV co-infection and APOBEC3G polymorphisms in a population from Burkina Faso.
Coinfection
Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients.
Colonic Neoplasms
A Bicistronic Adenoviral Vector Carrying Cytosine Deaminase and Granulocyte-Macrophage Colony-Stimulating Factor Increases the Therapeutic Efficacy of Cancer Gene Therapy.
Colonic Neoplasms
Antitumor activity of mutant bacterial cytosine deaminase gene for colon cancer.
Colonic Neoplasms
Antitumor Therapy Mediated by 5-Fluorocytosine and a Recombinant Fusion Protein Containing TSG-6 Hyaluronan Binding Domain and Yeast Cytosine Deaminase.
Colonic Neoplasms
APOBEC3G expression is correlated with poor prognosis in colon carcinoma patients with hepatic metastasis.
Colonic Neoplasms
CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase/5-fluorocytosine therapy directed by the carcinoembryonic antigen promoter.
Colonic Neoplasms
Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine.
Colonic Neoplasms
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice.
Colonic Neoplasms
Enzyme/prodrug gene therapy for human colon cancer cells using adenovirus-mediated transfer of the Escherichia coli cytosine deaminase gene driven by a CAG promoter associated with 5-fluorocytosine administration.
Colonic Neoplasms
In vivo gene therapy for colon cancer using adenovirus-mediated, transfer of the fusion gene cytosine deaminase and uracil phosphoribosyltransferase.
Colonic Neoplasms
Regional delivery and selective expression of a high-activity yeast cytosine deaminase in an intrahepatic colon cancer model.
Colonic Neoplasms
Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.
Colonic Neoplasms
Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats.
Colonic Neoplasms
Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts.
Colonic Neoplasms
Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
Colonic Neoplasms
Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs.
Colonic Neoplasms
[Efficacy of antitumour colon cancer cell vaccine modified by eschrichia coli cytosine deaminase gene]
Colonic Neoplasms
[Experimental studies on the treatment of colon cancer by cytosine deaminase gene and 5-fluorocytosine]
Colonic Neoplasms
[Hyperthermia enhanced the killing effect of 5-fluorocytosine on human colon cancer cell line transfected with cytosine deaminase gene]
Colorectal Neoplasms
A first step in the development of gene therapy for colorectal carcinoma: cloning, sequencing, and expression of Escherichia coli cytosine deaminase.
Colorectal Neoplasms
A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models.
Colorectal Neoplasms
Analysis of the human carcinoembryonic antigen promoter core region in colorectal carcinoma-selective cytosine deaminase gene therapy.
Colorectal Neoplasms
Antitumor effects and radiosensitization of cytosine deaminase and thymidine kinase fusion suicide gene on colorectal carcinoma cells.
Colorectal Neoplasms
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.
Colorectal Neoplasms
Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer.
Colorectal Neoplasms
Effective and safe gene therapy for colorectal carcinoma using the cytosine deaminase gene directed by the carcinoembryonic antigen promoter.
Colorectal Neoplasms
High and selective expression of yeast cytosine deaminase under a carcinoembryonic antigen promoter-enhancer.
Colorectal Neoplasms
In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase.
Colorectal Neoplasms
In vivo suicide gene therapy model using a newly discovered prostate-specific membrane antigen promoter/enhancer: a potential alternative approach to androgen deprivation therapy.
Colorectal Neoplasms
Integrative analysis of significant RNA-binding proteins in colorectal cancer metastasis.
Colorectal Neoplasms
Liposomal formulation of 5-fluorocytosine in suicide gene therapy with cytosine deaminase - for colorectal cancer.
Colorectal Neoplasms
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.
Colorectal Neoplasms
Radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells in culture transduced with cytosine deaminase gene.
Colorectal Neoplasms
Selective in vivo radiosensitization by 5-fluorocytosine of human colorectal carcinoma cells transduced with the E. coli cytosine deaminase (CD) gene.
Colorectal Neoplasms
Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene.
Colorectal Neoplasms
Suppression of the growth of human colorectal cancer cells by therapeutic stem cells expressing cytosine deaminase and interferon-? via their tumor-tropic effect in cellular and xenograft mouse models.
Colorectal Neoplasms
Tumor-specific chemo-radio-gene therapy for colorectal cancer cells using adenovirus vector expressing the cytosine deaminase gene.
Colorectal Neoplasms
Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts.
Colorectal Neoplasms
[Hyperthermia enhanced the killing effect of 5-fluorocytosine on human colon cancer cell line transfected with cytosine deaminase gene]
Colorectal Neoplasms
[In vitro antitumor effect of adenovirus containing CD-TK fusion gene driven by VEGF promoter on LoVo cells]
Colorectal Neoplasms
[X-ray combined with cytosine deaminase suicide gene therapy enhances killing of colorectal carcinoma cells in vitro]
Coronary Artery Disease
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes.
COVID-19
Differentially expressed immune response genes in COVID-19 patients based on disease severity.
COVID-19
Lung expression of genes putatively involved in SARS-CoV-2 infection is modulated in cis by germline variants.
Cystadenocarcinoma, Serous
[Anticancer effects of cytosine deaminase gene/5-fluorocytosine therapies to ovarian cancer in vivo]
Cystic Fibrosis
Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions.
Cystic Fibrosis
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes.
cytidine deaminase deficiency
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
cytosine deaminase deficiency
Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.
cytosine deaminase deficiency
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Diabetic Nephropathies
Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice.
Diphtheria
Inhibition of human immunodeficiency virus type 1 by Tat/Rev-regulated expression of cytosine deaminase, interferon alpha2, or diphtheria toxin compared with inhibition by transdominant Rev.
Dyslipidemias
Systems analysis of small signaling modules relevant to eight human diseases.
Encephalitis
Increased APOBEC3G expression is associated with extensive G-to-A hypermutation in viral DNA in rhesus macaque brain during lentiviral infection.
Encephalitis
Small ruminant lentiviral Vif proteins commonly utilize cyclophilin A, an evolutionarily and structurally conserved protein, to degrade ovine and caprine APOBEC3 proteins.
Endometrial Neoplasms
205 selective antitumor therapeutic effect of 5-fluorocytosine and interferon-Beta against breast and endometrial cancer cells by engineered stem cells expressing Cytosine deaminase and human interferon-Beta.
Endometrial Neoplasms
Antitumor Therapeutic Effects of Cytosine Deaminase and Interferon-{beta} Against Endometrial Cancer Cells Using Genetically Engineered Stem Cells In Vitro.
Endometrial Neoplasms
High APOBEC1 Complementation Factor Expression Positively Modulates the Proliferation, Invasion, and Migration of Endometrial Cancer Cells Through Regulating P53/P21 Signaling Pathway.
Epilepsy
A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.
Epilepsy
Corrigendum: A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.
Epstein-Barr Virus Infections
APOBEC-mediated DNA alterations: A possible new mechanism of carcinogenesis in EBV-positive gastric cancer.
Equine Infectious Anemia
Equine infectious anemia virus resists the antiretroviral activity of equine APOBEC3 proteins through a packaging-independent mechanism.
Equine Infectious Anemia
Lentiviral Vif degrades the APOBEC3Z3/APOBEC3H protein of its mammalian host and is capable of cross-species activity.
Equine Infectious Anemia
Restriction of equine infectious anemia virus by equine APOBEC3 cytidine deaminases.
Equine Infectious Anemia
Role of cullin-elonginB-elonginC E3 complex in bovine immunodeficiency virus and maedi-visna virus Vif-mediated degradation of host A3Z2-Z3 proteins.
Esophageal Squamous Cell Carcinoma
Long non-coding RNA ESCCAL-1 promotes esophageal squamous cell carcinoma by down regulating the negative regulator of APOBEC3G.
Extranodal Extension
Cytosine deaminase-uracil phosphoribosyltransferase and interleukin (IL)-12 and IL-18: a multimodal anticancer interface marked by specific modulation in serum cytokines.
Fibrosarcoma
Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.
Foot-and-Mouth Disease
Suicidal gene therapy in the effective control of primary human hepatocellular carcinoma as monitored by noninvasive bioimaging.
Gallstones
Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease.
Glioblastoma
Comparative evaluation of preclinical in vivo models for the assessment of replicating retroviral vectors for the treatment of glioblastoma.
Glioblastoma
Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models.
Glioma
5-Fluorocytosine-mediated apoptosis and DNA damage in glioma cells engineered to express cytosine deaminase and their enhancement with interferon.
Glioma
APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death.
Glioma
Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus.
Glioma
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Glioma
Combined effects of mesenchymal stem cells carrying cytosine deaminase gene with 5-fluorocytosine and temozolomide in orthotopic glioma model.
Glioma
Diffusion MRI detects early events in the response of a glioma model to the yeast cytosine deaminase gene therapy strategy.
Glioma
Dihydropyrimidine Dehydrogenase Is a Prognostic Marker for Mesenchymal Stem Cell-Mediated Cytosine Deaminase Gene and 5-Fluorocytosine Prodrug Therapy for the Treatment of Recurrent Gliomas.
Glioma
Enhancing the Oncolytic Activity of CD133-Targeted Measles Virus: Receptor Extension or Chimerism with Vesicular Stomatitis Virus Are Most Effective.
Glioma
Feasibility of intracerebrally administering multiple doses of genetically modified neural stem cells to locally produce chemotherapy in glioma patients.
Glioma
Highly efficient and tumor-restricted gene transfer to malignant gliomas by replication-competent retroviral vectors.
Glioma
Human neural stem cells transduced with IFN-beta and cytosine deaminase genes intensify bystander effect in experimental glioma.
Glioma
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha.
Glioma
In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine.
Glioma
Increased sensitivity of glioma cells to 5-fluorocytosine following photo-chemical internalization enhanced nonviral transfection of the cytosine deaminase suicide gene.
Glioma
Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.
Glioma
Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids.
Glioma
MicroRNA 142-3p attenuates spread of replicating retroviral vector in hematopoietic lineage-derived cells while maintaining an antiviral immune response.
Glioma
Mutation of Escherichia coli cytosine deaminase significantly enhances molecular chemotherapy of human glioma.
Glioma
Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients.
Glioma
Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier.
Glioma
Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector.
Glioma
Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity.
Glioma
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Glioma
Targeting rat brainstem glioma using human neural stem cells and human mesenchymal stem cells.
Glioma
The antitumor effect of mesenchymal stem cells transduced with a lentiviral vector expressing cytosine deaminase in a rat glioma model.
Glioma
The enhanced efficacy of herpes simplex virus by lentivirus mediated VP22 and cytosine deaminase gene therapy against glioma.
Glioma
Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer.
Glioma
Therapeutic effect of genetically modified human neural stem cells encoding cytosine deaminase on experimental glioma.
Glioma
Therapeutic effect of suicide gene-transferred mesenchymal stem cells in a rat model of glioma.
Glioma
Three-dimensional assessment of bystander effects of mesenchymal stem cells carrying a cytosine deaminase gene on glioma cells.
Glioma
Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.
Glioma
Transduction of cytosine deaminase gene makes rat glioma cells highly sensitive to 5-fluorocytosine.
Glioma
Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy.
Glioma
VP22 and cytosine deaminase fusion gene modified tissue-engineered neural stem cells for glioma therapy.
Gliosarcoma
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Gliosarcoma
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Head and Neck Neoplasms
Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model.
Head and Neck Neoplasms
Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase.
Head and Neck Neoplasms
HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer.
Head and Neck Neoplasms
Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation.
Hemoglobin SC Disease
Differentially expressed immune response genes in COVID-19 patients based on disease severity.
Hepatitis
Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes.
Hepatitis
Association of human APOBEC3 cytidine deaminases with the generation of hepatitis virus B x antigen mutants and hepatocellular carcinoma.
Hepatitis
Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer.
Hepatitis
[Expression and subcellular localization of APOBEC3G in peripheral blood mononuclear cells and liver tissues of chronic HBV patients]
Hepatitis B
A3G-induced mutations show low prevalence and exhibit plus strand regional distribution in hepatitis B virus DNA from patients with non-hepatocellular carcinoma (HCC) and HCC.
Hepatitis B
Anti-viral protein APOBEC3G is induced by interferon-alpha stimulation in human hepatocytes.
Hepatitis B
APOBEC1 and APOBEC3 cytidine deaminases as restriction factors for hepadnaviral genomes in non-humans in vivo.
Hepatitis B
APOBEC3DE Antagonizes Hepatitis B Virus Restriction Factors APOBEC3F and APOBEC3G.
Hepatitis B
APOBEC3G directly binds Hepatitis B virus core protein in cell and cell free systems.
Hepatitis B
Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma.
Hepatitis B
Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications.
Hepatitis B
Cytidine deaminases as a weapon against retroviruses and a new target for antiviral therapy.
Hepatitis B
Deamination-independent inhibition of hepatitis B virus reverse transcription by APOBEC3G.
Hepatitis B
Different antiviral activities of natural APOBEC3C, APOBEC3G, and APOBEC3H variants against hepatitis B virus.
Hepatitis B
Effects of point mutations in the cytidine deaminase domains of APOBEC3B on replication and hypermutation of hepatitis B virus in vitro.
Hepatitis B
Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection.
Hepatitis B
Extensive editing of both hepatitis B virus DNA strands by APOBEC3 cytidine deaminases in vitro and in vivo.
Hepatitis B
Full genome ultra-deep pyrosequencing associates G-to-A hypermutation of the hepatitis B virus genome with the natural progression of hepatitis B.
Hepatitis B
Genetic editing of HBV DNA by monodomain human APOBEC3 cytidine deaminases and the recombinant nature of APOBEC3G.
Hepatitis B
Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.
Hepatitis B
Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus.
Hepatitis B
Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.
Hepatitis B
Influence of Pattern Recognition Receptor Ligands on Induction of Innate Immunity and Control of Hepatitis B Virus Infection.
Hepatitis B
Interferon-inducible expression of APOBEC3 editing enzymes in human hepatocytes and inhibition of hepatitis B virus replication.
Hepatitis B
N-terminal and C-terminal cytosine deaminase domain of APOBEC3G inhibit hepatitis B virus replication.
Hepatitis B
Protein transduction with bacterial cytosine deaminase fused to the TLM intercellular transport motif induces profound chemosensitivity to 5-fluorocytosine in human hepatoma cells.
Hepatitis B
Reverse transcriptase- and RNA packaging signal-dependent incorporation of APOBEC3G into hepatitis B virus nucleocapsids.
Hepatitis B
Roles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis.
Hepatitis B
STAT1-Independent Cell Type-Specific Regulation of Antiviral APOBEC3G by IFN-{alpha}.
Hepatitis B
The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses.
Hepatitis B, Chronic
Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma.
Hepatitis B, Chronic
Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer.
Hepatitis B, Chronic
Interferon-alpha Induces High Expression of APOBEC3G and STAT-1 in Vitro and in Vivo.
Hepatitis B, Chronic
Polymorphic APOBEC3 modulates chronic hepatitis B in Moroccan population.
Hepatitis B, Chronic
[Expression and subcellular localization of APOBEC3G in peripheral blood mononuclear cells and liver tissues of chronic HBV patients]
Hepatitis C, Chronic
High expression of APOBEC3G in patients infected with hepatitis C virus.
Hepatitis, Chronic
High expression of APOBEC3G in patients infected with hepatitis C virus.
Hepatitis, Chronic
[Association between APOBEC3G polymorphisms and susceptibility to chronic hepatitis B].
Herpes Simplex
207 engineered human amniotic fluid-derived stem cells by expressing Cytosine deaminase (cd) and thymidine kinase (hsv-tk) mediate targeting killing effect in breast cancer cells.
Herpes Simplex
A dual drug sensitive L. major induces protection without lesion in C57BL/6 mice.
Herpes Simplex
A novel fusion suicide gene yeast CDglyTK plays a role in radio-gene therapy of nasopharyngeal carcinoma.
Herpes Simplex
A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.
Herpes Simplex
A preliminary study on the construction of double suicide gene delivery vectors by mesenchymal stem cells and the in vitro inhibitory effects on SKOV3 cells.
Herpes Simplex
Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity.
Herpes Simplex
Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.
Herpes Simplex
Adenovirus-mediated targeted gene therapy for breast cancer and for purging hematopoietic stem-cell sources.
Herpes Simplex
Antitumor efficacy of oncolytic HSV-1 expressing cytosine deaminase is synergistically enhanced by DPD down-regulation and EMT inhibition in uveal melanoma xenograft.
Herpes Simplex
Combined antitumor effects of an adenoviral cytosine deaminase/thymidine kinase fusion gene in rat C6 glioma.
Herpes Simplex
Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes.
Herpes Simplex
Comparison of gene therapy with the herpes simplex virus thymidine kinase gene and the bacterial cytosine deaminase gene for the treatment of hepatocellular carcinoma.
Herpes Simplex
Comparison of the effects of three different toxin genes and their levels of expression on cell growth and bystander effect in lung adenocarcinoma.
Herpes Simplex
Computational modeling and functional analysis of Herpes simplex virus type-1 thymidine kinase and Escherichia coli cytosine deaminase fusion protein.
Herpes Simplex
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy.
Herpes Simplex
Double suicide gene (cytosine deaminase and herpes simplex virus thymidine kinase) but not single gene transfer allows reliable elimination of tumor cells in vivo.
Herpes Simplex
Double suicide gene therapy using a replication defective herpes simplex virus vector reveals reciprocal interference in a malignant glioma model.
Herpes Simplex
Dual-vector prodrug activator gene therapy using retroviral replicating vectors.
Herpes Simplex
Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors.
Herpes Simplex
Enzyme-targeted, nucleoside-based radiopharmaceuticals for scintigraphic monitoring of gene transfer and expression.
Herpes Simplex
Ex vivo delivery of suicide genes into melanoma cells using epidermal growth factor receptor-specific Fab immunogene.
Herpes Simplex
Fusogenic membrane glycoproteins as a novel class of genes for the local and immune-mediated control of tumor growth.
Herpes Simplex
Gene transfer into human prostate adenocarcinoma cells with an adenoviral vector: Hyperthermia enhances a double suicide gene expression, cytotoxicity and radiotoxicity.
Herpes Simplex
Genetic editing of herpes simplex virus 1 and Epstein-Barr herpesvirus genomes by human APOBEC3 cytidine deaminases in culture and in vivo.
Herpes Simplex
GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo.
Herpes Simplex
Highly efficient gene transfer to solid tumors in vivo by tumor-selective replicating retrovirus vectors.
Herpes Simplex
Human amniotic fluid-derived stem cells expressing cytosine deaminase and thymidine kinase inhibits the growth of breast cancer cells in cellular and xenograft mouse models.
Herpes Simplex
In vivo and in vitro glioma cell killing induced by an adenovirus expressing both cytosine deaminase and thymidine kinase and its association with interferon-alpha.
Herpes Simplex
In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.
Herpes Simplex
Killing effect of coexpressing cytosine deaminase and thymidine kinase on rat vascular smooth muscle cells.
Herpes Simplex
Killing Epstein-Barr virus-positive B lymphocytes by gene therapy: comparing the efficacy of cytosine deaminase and herpes simplex virus thymidine kinase.
Herpes Simplex
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Herpes Simplex
Multimodality therapy with a replication-conditional herpes simplex virus 1 mutant that expresses yeast cytosine deaminase for intratumoral conversion of 5-fluorocytosine to 5-fluorouracil.
Herpes Simplex
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination.
Herpes Simplex
Oncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma.
Herpes Simplex
Oncolytic Herpes simplex virus expressing yeast cytosine deaminase: relationship between viral replication, transgene expression, prodrug bioactivation.
Herpes Simplex
Phase I study of replication-competent adenovirus-mediated double suicide gene therapy for the treatment of locally recurrent prostate cancer.
Herpes Simplex
Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer.
Herpes Simplex
Quantitative evaluation and comparison of two prodrug-activating suicide gene therapies on oral squamous cell carcinoma.
Herpes Simplex
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Herpes Simplex
Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy.
Herpes Simplex
Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer.
Herpes Simplex
Reversibly immortalized hepatic progenitor cell line containing double suicide genes.
Herpes Simplex
Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity.
Herpes Simplex
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Herpes Simplex
Simultaneous Cre catalyzed recombination of two alleles to restore neomycin sensitivity and facilitate homozygous mutations.
Herpes Simplex
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Herpes Simplex
Targeted killing effects of double CD and TK suicide genes controlled by survivin promoter on gastric cancer cell.
Herpes Simplex
The enhanced efficacy of herpes simplex virus by lentivirus mediated VP22 and cytosine deaminase gene therapy against glioma.
Herpes Simplex
Treatment of thyroid carcinoma cells with four different suicide gene/prodrug combinations in vitro.
Herpes Simplex
Viral therapies for glioblastoma and high-grade gliomas in adults: a systematic review.
Herpes Simplex
[Antitumor effects of cytosine deaminase and HSV-tk double suicide gene with adenovirus mediation on rectal cancer cells]
Herpes Simplex
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
Herpes Simplex
[Effects of recombinant adenovirus-mediated double suicide genes on implanted human keloid: experiment with athymic mice]
Herpes Simplex
[Killing effects of PWZL plasmid-mediated double suicide gene on human lens epithelium cells]
Herpes Simplex
[The killing effects of two prodrug sensitivity genes on human pancreatic carcinoma cells PC-2]
HIV Infections
A new approach to an AIDS vaccine: creating antibodies to HIV vif will enable apobec3G to turn HIV-infection into a benign problem.
HIV Infections
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.
HIV Infections
APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians.
HIV Infections
APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression.
HIV Infections
APOBEC3G-Augmented Stem Cell Therapy to Modulate HIV Replication: A Computational Study.
HIV Infections
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals.
HIV Infections
ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
HIV Infections
Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.
HIV Infections
Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation.
HIV Infections
Evaluating the contribution of APOBEC3G haplotypes, on influencing HIV infection in a Zimbabwean paediatric population.
HIV Infections
Fab-based inhibitors reveal ubiquitin independent functions for HIV Vif neutralization of APOBEC3 restriction factors.
HIV Infections
HSV-2 Cellular Programming Enables Productive HIV Infection in Dendritic Cells.
HIV Infections
Human immunodeficiency virus 1 (HIV-1) virion infectivity factor (Vif) is part of reverse transcription complexes and acts as an accessory factor for reverse transcription.
HIV Infections
Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity.
HIV Infections
Reward versus risk: DNA cytidine deaminases triggering immunity and disease.
HIV Infections
Systems analysis of small signaling modules relevant to eight human diseases.
HIV Infections
Understanding the regulation of APOBEC3 expression: Current evidence and much to learn.
HIV Infections
[Cellular restriction factors that inhibit human immunodeficiency virus replication: new strategies in antiretroviral therapy].
Homozygous Familial Hypercholesterolemia
Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis.
Infections
A model for oligomeric regulation of APOBEC3G cytosine deaminase-dependent restriction of HIV.
Infections
A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.
Infections
Accessory genes confer a high replication rate to virulent feline immunodeficiency virus.
Infections
Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.
Infections
Adenovirus mediated cytosine deaminase gene transduction and 5-fluorocytosine therapy sensitizes mouse prostate cancer cells to irradiation.
Infections
Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.
Infections
Antibody-Directed Double Suicide Gene Therapy Targeting of MUC1-Positive Leukemia Cells in Vitro and in Vivo.
Infections
Apobec 3G efficiently reduces infectivity of the human exogenous gammaretrovirus XMRV.
Infections
Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.
Infections
APOBEC3 inhibition of MMTV infection: the role of cytidine deamination versus inhibition of reverse transcription.
Infections
APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo.
Infections
APOBEC3G expression is dysregulated in primary HIV-1 infection and polymorphic variants influence CD4+ T-cell counts and plasma viral load.
Infections
APOBEC3G genetic variants and their association with risk of HIV infection in highly exposed Caucasians.
Infections
APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression.
Infections
APOBEC3G upregulation by alpha interferon restricts human immunodeficiency virus type 1 infection in human peripheral plasmacytoid dendritic cells.
Infections
APOBEC3G-UBA2 fusion as a potential strategy for stable expression of APOBEC3G and inhibition of HIV-1 replication.
Infections
APOBEC3G/3A Expression in Human Immunodeficiency Virus Type 1-Infected Individuals Following Initiation of Antiretroviral Therapy Containing Cenicriviroc or Efavirenz.
Infections
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individuals.
Infections
Association of single nucleotide polymorphisms of APOBEC3G with susceptibility to HIV-1 infection and disease progression among men engaging in homosexual activity in northern China.
Infections
Biochemical differentiation of APOBEC3F and APOBEC3G proteins associated with HIV-1 life cycle.
Infections
Characterization of Ovine A3Z1 Restriction Properties against Small Ruminant Lentiviruses (SRLVs).
Infections
Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.
Infections
Characterization of RNA binding and chaperoning activities of HIV-1 Vif protein. Importance of the C-terminal unstructured tail.
Infections
Comprehensive genetic and epigenetic analysis of occult hepatitis B from liver tissue samples.
Infections
Correlation of APOBEC3G Polymorphism with Human Papillomavirus (HPV) Persistent Infection and Progression of Cervical Lesions.
Infections
Correlation of Apolipoprotein B mRNA-editing Enzyme, Catalytic Polypeptide- like 3G Genetic Variant rs8177832 with HIV-1 Predisposition in Pakistani Population.
Infections
Crystal Structure of a Soluble APOBEC3G Variant Suggests ssDNA to Bind in a Channel that Extends between the Two Domains.
Infections
CUL5 and APOBEC3G Polymorphisms are Partially Implicated in HIV-1 Infection and Antiretroviral Therapy in a Brazilian Population.
Infections
Current topics in prevention of human T-cell leukemia virus type i infection: NF-kappa B inhibitors and APOBEC3.
Infections
Cytidine deaminase APOBEC3B interacts with heterogeneous nuclear ribonucleoprotein K and suppresses hepatitis B virus expression.
Infections
Cytoplasmic APOBEC3G restricts incoming Vif-positive human immunodeficiency virus type 1 and increases two-long terminal repeat circle formation in activated T-helper-subtype cells.
Infections
Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted antiviral functions of APOBEC3G.
Infections
Defining APOBEC3 expression patterns in human tissues and hematopoietic cell subsets.
Infections
Defining HIV-1 Vif residues that interact with CBF? by site-directed mutagenesis.
Infections
Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes.
Infections
Early biodistribution and persistence of a protective live attenuated SIV vaccine elicits localised innate responses in multiple lymphoid tissues.
Infections
Effect of Vaginal Immunization with HIVgp140 and HSP70 on HIV-1 Replication and Innate and T Cell Adaptive Immunity in Women.
Infections
Endogenous APOBEC3B restricts LINE-1 retrotransposition in transformed cells and human embryonic stem cells.
Infections
Enzyme/prodrug gene therapy approach for breast cancer using a recombinant adenovirus expressing Escherichia coli cytosine deaminase.
Infections
Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection.
Infections
Expression and regulation of antiviral protein APOBEC3G in human neuronal cells.
Infections
Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection.
Infections
Extensive Replication of a Retroviral Replicating Vector Can Expand the A Bulge in the Encephalomyocarditis Virus Internal Ribosome Entry Site and Change Translation Efficiency of the Downstream Transgene.
Infections
Full-Length Glycosylated Gag of Murine Leukemia Virus Can Associate with the Viral Envelope as a Type I Integral Membrane Protein.
Infections
Functional Analysis and Structural Modeling of Human APOBEC3G Reveals the Role of Evolutionarily Conserved Elements in HIV-1 and Alu Inhibition.
Infections
Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.
Infections
Fv1 Restriction and Retrovirus Vaccine Immunity in Apobec3-Deficient 129P2 Mice.
Infections
Generation of an HIV Resistant T-cell Line by Targeted "Stacking" of Restriction Factors.
Infections
HBsAg blocks TYPE I IFN induced up-regulation of A3G through inhibition of STAT3.
Infections
Hepatitis B virus X protein is capable of down-regulating protein level of host antiviral protein APOBEC3G.
Infections
Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication.
Infections
HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.
Infections
Human APOBEC3 induced mutation of human immunodeficiency virus type-1 contributes to adaptation and evolution in natural infection.
Infections
Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif.
Infections
Human APOBEC3G Can Restrict Retroviral Infection in Avian Cells and Acts Independently of both UNG and SMUG1.
Infections
Human immunodeficiency virus 1 (HIV-1) virion infectivity factor (Vif) is part of reverse transcription complexes and acts as an accessory factor for reverse transcription.
Infections
Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation.
Infections
Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3.
Infections
Identification of an arsenic-sensitive block to primate lentiviral infection of human dendritic cells.
Infections
IFN-? and Lipopolysaccharide Upregulate APOBEC3 mRNA through Different Signaling Pathways.
Infections
Immunoglobulin VH gene diversity and somatic hypermutation during SIV infection of rhesus macaques.
Infections
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.
Infections
Increased APOBEC3G expression is associated with extensive G-to-A hypermutation in viral DNA in rhesus macaque brain during lentiviral infection.
Infections
Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients.
Infections
Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.
Infections
Influence of primate lentiviral Vif and proteasome inhibitors on human immunodeficiency virus type 1 virion packaging of APOBEC3G.
Infections
Innate immune defense defines susceptibility of sarcoma cells to measles vaccine virus-based oncolysis.
Infections
Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.
Infections
Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model.
Infections
Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation.
Infections
Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.
Infections
Mucosal and peripheral Lin- HLA-DR+ CD11c/123- CD13+ CD14- mononuclear cells are preferentially infected during acute simian immunodeficiency virus infection.
Infections
Multifaceted HIV-1 Vif interactions with human E3 ubiquitin ligase and APOBEC3s.
Infections
Murine Leukemia Virus P50 Protein Counteracts APOBEC3 by Blocking Its Packaging.
Infections
Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G.
Infections
Mutational pressure by host APOBEC3s more strongly affects genes expressed early in the lytic phase of herpes simplex virus-1 (HSV-1) and human polyomavirus (HPyV) infection.
Infections
Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits.
Infections
Non-lytic Lymphocytes Engineered to Express Virus-specific T-cell Receptors Limit HBV Infection by Activating APOBEC3.
Infections
Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.
Infections
Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in Friend virus-infected mice.
Infections
Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional BAFF-R.
Infections
Pokeweed antiviral protein restores levels of cellular APOBEC3G during HIV-1 infection by depurinating Vif mRNA.
Infections
PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas.
Infections
Quantifying the antiviral effect of APOBEC3 on HIV-1 infection in humanized mouse model.
Infections
Reassessing the role of APOBEC3G in human immunodeficiency virus type 1 infection of quiescent CD4+ T-cells.
Infections
Regulation of HIV-1 Infection in Cells Derived from 1 Purified CD34+ Cells Through Manipulation of APOBEC3G Expression.
Infections
Relationship between human immunodeficiency type 1 infection and expression of human APOBEC3G and APOBEC3F.
Infections
Requirements for nucleocapsid-mediated regulation of reverse transcription during the late steps of HIV-1 assembly.
Infections
Restriction by APOBEC3 proteins of endogenous retroviruses with an extracellular life cycle: ex vivo effects and in vivo "traces" on the murine IAPE and human HERV-K elements.
Infections
Restriction of Porcine Endogenous Retrovirus by Porcine APOBEC3 Cytidine Deaminases.
Infections
Retraction. Cellular APOBEC3G restricts HIV-1 infection in resting CD4(+) T cells.
Infections
Ribonuclease L is not critical for innate restriction and adaptive immunity against Friend retrovirus infection.
Infections
Sensitization of prostate cancer cell lines to 5-fluorocytosine induced by adenoviral vector carrying a CD transcription unit.
Infections
Single-strand specificity of APOBEC3G accounts for minus-strand deamination of the HIV genome.
Infections
Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity.
Infections
Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association.
Infections
Suppression of HIV-1 infection by APOBEC3 proteins in primary human CD4(+) T cells is associated with inhibition of processive reverse transcription as well as excessive cytidine deamination.
Infections
Target cell-mediated editing of HIV-1 cDNA by APOBEC3 proteins in human macrophages.
Infections
The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles.
Infections
The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches.
Infections
The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo.
Infections
The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral Replication.
Infections
The Cytidine Deaminase APOBEC3 Family Is Subject to Transcriptional Regulation by p53.
Infections
The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.
Infections
The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.
Infections
The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain.
Infections
The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys.
Infections
Translational regulation of APOBEC3G mRNA by Vif requires its 5'UTR and contributes to restoring HIV-1 infectivity.
Infections
Vif-deficient HIV reverse transcription complexes (RTCs) are subject to structural changes and mutation of RTC-associated reverse transcription products.
Infections
Vpr counteracts the restriction of LAPTM5 to promote HIV-1 infection in macrophages.
Infections
Vpr14-88-Apobec3G fusion protein is efficiently incorporated into Vif-positive HIV-1 particles and inhibits viral infection.
Infections
[The associations between polymorphisms of APOBEC3G and different outcomes of persistent HBV infection]
Influenza, Human
High level expression of the anti-retroviral protein APOBEC3G is induced by influenza A virus but does not confer antiviral activity.
Keloid
[Effects of recombinant adenovirus-mediated double suicide genes on implanted human keloid: experiment with athymic mice]
Leukemia
Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.
Leukemia
Amino-terminal region of the human immunodeficiency virus type 1 nucleocapsid is required for human APOBEC3G packaging.
Leukemia
Antibody-Directed Double Suicide Gene Therapy Targeting of MUC1-Positive Leukemia Cells in Vitro and in Vivo.
Leukemia
Antitumor effects of cytosine deaminase and thymidine kinase fusion suicide gene under the control of mdr1 promoter in mdr1 positive leukemia cells.
Leukemia
APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair.
Leukemia
Cytidine deaminases as a weapon against retroviruses and a new target for antiviral therapy.
Leukemia
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.
Leukemia
Deamination intensity profiling of human APOBEC3 protein activity along the near full-length genomes of HIV-1 and MoMLV by HyperHRM analysis.
Leukemia
Design and selection of toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.
Leukemia
Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion.
Leukemia
Enhanced replication and pathogenesis of Moloney murine leukemia virus in mice defective in the murine APOBEC3 gene.
Leukemia
Evolution of different antiviral strategies in wild mouse populations exposed to different gammaretroviruses.
Leukemia
Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection.
Leukemia
Full-Length Glycosylated Gag of Murine Leukemia Virus Can Associate with the Viral Envelope as a Type I Integral Membrane Protein.
Leukemia
Human and murine APOBEC3s restrict replication of koala retrovirus by different mechanisms.
Leukemia
Human APOBEC3 proteins can inhibit xenotropic murine leukemia virus-related virus infectivity.
Leukemia
Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3.
Leukemia
In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.
Leukemia
Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.
Leukemia
Innate cellular defenses of APOBEC3 cytidine deaminases and viral counter-defenses.
Leukemia
Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons.
Leukemia
Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif-mediated ubiquitin-proteasome pathway.
Leukemia
Mouse APOBEC3 expression in NIH 3T3 cells mediates hypermutation of AKV murine leukemia virus.
Leukemia
Mouse APOBEC3 interferes with autocatalytic cleavage of murine leukemia virus Pr180gag-pol precursor and inhibits Pr65gag processing.
Leukemia
Murine APOBEC1 is a powerful mutator of retroviral and cellular RNA in vitro and in vivo.
Leukemia
Murine leukemia virus glycosylated Gag blocks apolipoprotein B editing complex 3 and cytosolic sensor access to the reverse transcription complex.
Leukemia
Repair of APOBEC3G-mutated retroviral DNA in vivo is facilitated by the host enzyme uracil DNA glycosylase 2.
Leukemia
Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid.
Leukemia
The betaretrovirus Mason-Pfizer monkey virus selectively excludes simian APOBEC3G from virion particles.
Leukemia
The glycosylated Gag protein of a murine leukemia virus inhibits the antiretroviral function of APOBEC3.
Leukemia, Feline
Identification of a Cullin5-ElonginB-ElonginC E3 complex in degradation of feline immunodeficiency virus Vif-mediated feline APOBEC3 proteins.
Leukemia, Lymphocytic, Chronic, B-Cell
APOBEC3 signature mutations in chronic lymphocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The growth of K562 human leukemia cells was inhibited by therapeutic neural stem cells in cellular and xenograft mouse models.
Leukemia, T-Cell
APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo.
Leukemia, T-Cell
Current topics in prevention of human T-cell leukemia virus type i infection: NF-kappa B inhibitors and APOBEC3.
Leukemia, T-Cell
Cytidine deaminases as a weapon against retroviruses and a new target for antiviral therapy.
Leukemia, T-Cell
Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases.
Leukemia, T-Cell
Human T cell leukemia virus type I is resistant to the antiviral effects of APOBEC3.
Leukemia, T-Cell
Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid.
Liver Cirrhosis
Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer.
Liver Cirrhosis
[Expression and subcellular localization of APOBEC3G in peripheral blood mononuclear cells and liver tissues of chronic HBV patients]
Liver Neoplasms
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
Liver Neoplasms
Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and comparison in chronic hepatitis B, liver cirrhosis and liver cancer.
Liver Neoplasms
Gene therapy for murine liver cancer by adenovirus-mediated cytosine deaminase gene.
Liver Neoplasms
Gene Therapy with Cytosine Deaminase and Endostatin Fusion Gene Mediated by Endothelial Progenitor Cells in Hepatomas.
Liver Neoplasms
Hepatitis B: modern concepts in pathogenesis--APOBEC3 cytidine deaminases as effectors in innate immunity against the hepatitis B virus.
Liver Neoplasms
Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5-fluorocytosine administration suppresses growth of 5-fluorouracil-sensitive liver cancer in mice.
Liver Neoplasms
Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-? via their tumor tropism to selectively target human hepatocarcinoma cells.
Liver Neoplasms
[Combined gene therapy for murine liver cancer with interleukin-18 and cytosine deaminase genes]
Liver Neoplasms
[Expression and subcellular localization of APOBEC3G in peripheral blood mononuclear cells and liver tissues of chronic HBV patients]
Lung Neoplasms
Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties.
Lung Neoplasms
Associations of cytosine deaminase gene polymorphisms with effectiveness of gemcitabine/cisplatin chemotherapy in patients of Xinjiang Uyghur and Han nationality with non-small cell lung cancer.
Lung Neoplasms
Genetically engineered stem cells expressing cytosine deaminase and interferon-? migrate to human lung cancer cells and have potentially therapeutic anti-tumor effects.
Lung Neoplasms
In vivo suicide gene therapy model using a newly discovered prostate-specific membrane antigen promoter/enhancer: a potential alternative approach to androgen deprivation therapy.
Lung Neoplasms
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Lung Neoplasms
Selective killing of lung cancer cells using carcinoembryonic antigen promoter and double suicide genes, thymidine kinase and cytosine deaminase (pCEA-TK/CD).
Lung Neoplasms
Single-nucleotide polymorphism of the DNA cytosine deaminase APOBEC3H haplotype I leads to enzyme destabilization and correlates with lung cancer.
Lung Neoplasms
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis.
Lung Neoplasms
[Combination of ARE and HRE cis- Regulatory Elements Elevates the Activity of Tumor-Specific hTERT Promoter].
Lupus Erythematosus, Systemic
Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus.
Lymphoma
Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.
Lymphoma
APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair.
Lymphoma
Expression of APOBEC family members as regulators of endogenous retroelements and malignant transformation in systemic autoimmunity.
Lymphoma
Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells.
Lymphoma
Safety and efficacy of an oncolytic viral strategy using bortezomib with ICE/R in relapsed/refractory HIV-positive lymphomas.
Lymphoma, B-Cell
Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.
Lymphoma, Primary Effusion
Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.
Malaria
Prolonged stability and sustained prodrug cell killing activity using receptor-mediated delivery of malarial circumsporozoite-cytosine deaminase fusion protein into liver cancer cells.
Measles
A novel armed oncolytic measles vaccine virus for the treatment of cholangiocarcinoma.
Measles
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
Measles
Enhanced killing of ovarian carcinoma using oncolytic measles vaccine virus armed with a yeast cytosine deaminase and uracil phosphoribosyltransferase.
Measles
KDELR2 Competes with Measles Virus Envelope Proteins for Cellular Chaperones Reducing Their Chaperone-Mediated Cell Surface Transport.
Measles
The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses.
Medulloblastoma
Neural stem cell-based dual suicide gene delivery for metastatic brain tumors.
Melanoma
A safe, effective in vivo gene therapy for melanoma using tyrosinase promoter-driven cytosine deaminase gene.
Melanoma
Antitumor efficacy of oncolytic HSV-1 expressing cytosine deaminase is synergistically enhanced by DPD down-regulation and EMT inhibition in uveal melanoma xenograft.
Melanoma
Augmentation of antitumor effect of adenovirus-mediated CD suicide gene therapy by cotransfer of interleukin 2 gene in melanoma-bearing mice.
Melanoma
Combined therapy of B16(F10) murine melanoma using E. coli cytosine deaminase gene and murine interleukin-4 gene.
Melanoma
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice.
Melanoma
Cytotoxic effects of 5-fluorocytosine on melanoma cells transduced with cytosine deaminase gene.
Melanoma
Ex vivo delivery of suicide genes into melanoma cells using epidermal growth factor receptor-specific Fab immunogene.
Melanoma
Oncolytic adenoviral vector carrying the cytosine deaminase gene for melanoma gene therapy.
Melanoma
PLK1 and NOTCH Positively Correlate in Melanoma and Their Combined Inhibition Results in Synergistic Modulations of Key Melanoma Pathways.
Melanoma
Prognostic implication and functional annotations of APOBEC3G expression in patients with Melanoma.
Melanoma
Selective augmentation of radiation effects by 5-fluorocytosine on murine B16(F10) melanoma cells transfected with cytosine deaminase gene.
Melanoma
The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.
Melanoma
Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells.
Melanoma
[Cytotoxicity of cytosine deaminase and herpes simplex virus thymidine kinase genes in melanoma cells is independent on promoter strength].
Melanoma
[Mesenchymal stem cells expressing cytosine deaminase inhibit growth of murine melanoma B16F10 in vivo].
Melanoma, Experimental
A safe, effective in vivo gene therapy for melanoma using tyrosinase promoter-driven cytosine deaminase gene.
Melanoma, Experimental
Interleukin-18 gene transfer increases antitumor effects of suicide gene therapy through efficient induction of antitumor immunity.
Multiple Myeloma
APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression.
Mumps
APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition.
Mumps
The innate antiviral factor APOBEC3G targets replication of measles, mumps and respiratory syncytial viruses.
Nasopharyngeal Carcinoma
A novel fusion suicide gene yeast CDglyTK plays a role in radio-gene therapy of nasopharyngeal carcinoma.
Neoplasm Metastasis
Adenovirus gene transfer vectors inhibit growth of lymphatic tumor metastases independent of a therapeutic transgene.
Neoplasm Metastasis
Annexin V-targeted enzyme prodrug therapy using cytosine deaminase in combination with 5-fluorocytosine.
Neoplasm Metastasis
Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice.
Neoplasm Metastasis
APOBEC3G expression is correlated with poor prognosis in colon carcinoma patients with hepatic metastasis.
Neoplasm Metastasis
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis.
Neoplasm Metastasis
Cancer-Specific Inhibitory Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-? Against Choriocarcinoma in Xenografted Metastatic Mouse Models.
Neoplasm Metastasis
Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells.
Neoplasm Metastasis
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells.
Neoplasm Metastasis
Gene therapy of metastatic colon carcinoma: regression of multiple hepatic metastases by adenoviral expression of bacterial cytosine deaminase.
Neoplasm Metastasis
Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases.
Neoplasm Metastasis
In situ transduction of cytosine deaminase gene followed by systemic use of 5-fluorocytosine inhibits tumor growth and metastasis in orthotopic prostate cancer mouse models.
Neoplasm Metastasis
Inhibitory effect of therapeutic genes, cytosine deaminase and interferon??, delivered by genetically engineered stem cells against renal cell carcinoma.
Neoplasm Metastasis
Integrative analysis of significant RNA-binding proteins in colorectal cancer metastasis.
Neoplasm Metastasis
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma.
Neoplasm Metastasis
Synergistic effect of therapeutic stem cells expressing cytosine deaminase and interferon-beta via apoptotic pathway in the metastatic mouse model of breast cancer.
Neoplasm Metastasis
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes.
Neoplasm Metastasis
The immune response elicited by mammary adenocarcinoma cells transduced with interferon-gamma and cytosine deaminase genes cures lung metastases by parental cells.
Neoplasm Metastasis
Therapeutic efficacy of replication-competent retrovirus vector-mediated suicide gene therapy in a multifocal colorectal cancer metastasis model.
Neoplasm Metastasis
Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes.
Neoplasm Metastasis
Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs.
Neoplasm Metastasis
[Vaccination by suicide gene therapy against a model of hepatic metastasis from colon cancer in the rat]
Neoplasms
5-Fluorocytosine combined with Fcy-hEGF fusion protein targets EGFR-expressing cancer cells.
Neoplasms
5-Fluorocytosine increases the toxicity of Wnt-targeting replicating adenoviruses that express cytosine deaminase as a late gene.
Neoplasms
A Bicistronic Adenoviral Vector Carrying Cytosine Deaminase and Granulocyte-Macrophage Colony-Stimulating Factor Increases the Therapeutic Efficacy of Cancer Gene Therapy.
Neoplasms
A high rate of polymerization during synthesis of mouse mammary tumor virus DNA alleviates hypermutation by APOBEC3 proteins.
Neoplasms
A novel mechanism of synergistic cytotoxicity with 5-fluorocytosine and ganciclovir in double suicide gene therapy.
Neoplasms
A novel oncolytic adenovirus expressing Escherichia coli cytosine deaminase exhibits potent antitumor effect on human solid tumors.
Neoplasms
A phase I trial of genetically modified Salmonella typhimurium expressing cytosine deaminase (TAPET-CD, VNP20029) administered by intratumoral injection in combination with 5-fluorocytosine for patients with advanced or metastatic cancer. Protocol no: CL-017. Version: April 9, 2001.
Neoplasms
A Phytase-Based Reporter System for Identification of Functional Secretion Signals in Bifidobacteria.
Neoplasms
A Protein Antagonist of Activation-Induced Cytidine Deaminase Encoded by a Complex Mouse Retrovirus.
Neoplasms
A Retroviral Replicating Vector Encoding Cytosine Deaminase and 5-FC Induces Immune Memory in Metastatic Colorectal Cancer Models.
Neoplasms
Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.
Neoplasms
Adenoviral transduction of a cytosine deaminase/thymidine kinase fusion gene into prostate carcinoma cells enhances prodrug and radiation sensitivity.
Neoplasms
Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells.
Neoplasms
Adenovirus gene transfer vectors inhibit growth of lymphatic tumor metastases independent of a therapeutic transgene.
Neoplasms
Adenovirus-mediated combined suicide gene and interleukin-2 gene therapy for the treatment of established tumor and induction of antitumor immunity.
Neoplasms
Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts.
Neoplasms
Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice.
Neoplasms
Adenovirus-mediated tissue-specific cytosine deaminase gene therapy for human hepatocellular carcinoma with different AFP expression levels.
Neoplasms
Alanine-scanning mutagenesis reveals a cytosine deaminase mutant with altered substrate preference.
Neoplasms
Analysis of APOBEC3A/3B germline deletion polymorphism in breast, cervical and oral cancers from South India and its impact on miRNA regulation.
Neoplasms
Annexin V-targeted enzyme prodrug therapy using cytosine deaminase in combination with 5-fluorocytosine.
Neoplasms
Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice.
Neoplasms
Anticancer effects of the engineered stem cells transduced with therapeutic genes via a selective tumor tropism caused by vascular endothelial growth factor toward HeLa cervical cancer cells.
Neoplasms
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis.
Neoplasms
Antitumor effects of genetically engineered stem cells expressing yeast cytosine deaminase in lung cancer brain metastases via their tumor-tropic properties.
Neoplasms
Antitumor Therapy Mediated by 5-Fluorocytosine and a Recombinant Fusion Protein Containing TSG-6 Hyaluronan Binding Domain and Yeast Cytosine Deaminase.
Neoplasms
Antitumour activity of Salmonella typhimurium VNP20047 in B16(F10) murine melanoma model.
Neoplasms
apoB and apobec1, two genes key to lipid metabolism, are transcriptionally regulated by p53.
Neoplasms
APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic Tumors.
Neoplasms
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.
Neoplasms
APOBEC-mediated DNA alterations: A possible new mechanism of carcinogenesis in EBV-positive gastric cancer.
Neoplasms
APOBEC1 complementation factor facilitates cell migration by promoting nucleus translocation of SMAD3 in renal cell carcinoma cells.
Neoplasms
APOBEC1 cytosine deaminase activity on single-stranded DNA is suppressed by replication protein A.
Neoplasms
APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion.
Neoplasms
APOBEC3-Mediated RNA Editing in Breast Cancer is Associated with Heightened Immune Activity and Improved Survival.
Neoplasms
APOBEC3B and IL-6 form a positive feedback loop in hepatocellular carcinoma cells.
Neoplasms
APOBEC3B expression in breast cancer cell lines and tumors depends on the estrogen receptor status.
Neoplasms
APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression.
Neoplasms
APOBEC3G acts as a therapeutic target in mesenchymal gliomas by sensitizing cells to radiation-induced cell death.
Neoplasms
APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma.
Neoplasms
APOBEC3G is increasingly expressed on the human uterine cervical intraepithelial neoplasia along with disease progression.
Neoplasms
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis.
Neoplasms
Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like Gene Expression, RNA Editing, and MicroRNAs Regulation.
Neoplasms
Assessing and Overcoming Resistance Phenomena against a Genetically Modified Vaccinia Virus in Selected Cancer Cell Lines.
Neoplasms
Association of APOBEC3 deletion with cancer risk: A meta-analysis of 26 225 cases and 37 201 controls.
Neoplasms
Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors.
Neoplasms
B-Myb Induces APOBEC3B Expression Leading to Somatic Mutation in Multiple Cancers.
Neoplasms
Bacterial cytosine deaminase mutants created by molecular engineering show improved 5-fluorocytosine-mediated cell killing in vitro and in vivo.
Neoplasms
Bi-Functional Radiotheranostics of 188Re-Liposome-Fcy-hEGF for Radio- and Chemo-Therapy of EGFR-Overexpressing Cancer Cells.
Neoplasms
Brain tumor eradication and prolonged survival from intratumoral conversion of 5-fluorocytosine to 5-fluorouracil using a nonlytic retroviral replicating vector.
Neoplasms
Bystander effect from cytosine deaminase and uracil phosphoribosyl transferase genes in vitro: A partial contribution of gap junctions.
Neoplasms
Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors.
Neoplasms
Cloning, overexpression, and purification of cytosine deaminase from Saccharomyces cerevisiae.
Neoplasms
Combination of cytosine deaminase suicide gene expression with DR5 antibody treatment increases cancer cell cytotoxicity.
Neoplasms
Combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice.
Neoplasms
Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine.
Neoplasms
Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model.
Neoplasms
Combined suicide gene therapy for human colon cancer cells using adenovirus-mediated transfer of escherichia coli cytosine deaminase gene and Escherichia coli uracil phosphoribosyltransferase gene with 5-fluorocytosine.
Neoplasms
Comparison of different methods to assess the cytotoxic effects of cytosine deaminase and thymidine kinase gene therapy.
Neoplasms
Concomitant expression of E. coli cytosine deaminase and uracil phosphoribosyltransferase improves the cytotoxicity of 5-fluorocytosine.
Neoplasms
Conformational Switch Regulates the DNA Cytosine Deaminase Activity of Human APOBEC3B.
Neoplasms
Conjugation of poly-L-lysine to bacterial cytosine deaminase improves the efficacy of enzyme/prodrug cancer therapy.
Neoplasms
Correlation of APOBEC3 in tumor tissues with clinico-pathological features and survival from hepatocellular carcinoma after curative hepatectomy.
Neoplasms
Correlation of APOBEC3G Polymorphism with Human Papillomavirus (HPV) Persistent Infection and Progression of Cervical Lesions.
Neoplasms
Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy.
Neoplasms
Cytosine Deaminase APOBEC3A Sensitizes Leukemia Cells to Inhibition of the DNA Replication Checkpoint.
Neoplasms
Cytosine deaminase expressing human mesenchymal stem cells mediated tumour regression in melanoma bearing mice.
Neoplasms
Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer.
Neoplasms
Cytosine deaminase-uracil phosphoribosyltransferase and interleukin (IL)-12 and IL-18: a multimodal anticancer interface marked by specific modulation in serum cytokines.
Neoplasms
Cytosine deaminase/5-fluorocytosine-based vaccination against liver tumors: evidence of distant bystander effect.
Neoplasms
Cytotoxic effect of replication-competent adenoviral vectors carrying L-plastin promoter regulated E1A and cytosine deaminase genes in cancers of the breast, ovary and colon.
Neoplasms
Cytotoxic effects of 5-fluorocytosine on melanoma cells transduced with cytosine deaminase gene.
Neoplasms
Delayed Progression of Lung Metastases Following Delivery of a Prodrug-activating Enzyme.
Neoplasms
Design and selection of toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression.
Neoplasms
Detection of cytosine deaminase in genetically modified tumor cells by specific antibodies.
Neoplasms
Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy.
Neoplasms
Diffusion magnetic resonance imaging: an imaging treatment response biomarker to chemoradiotherapy in a mouse model of squamous cell cancer of the head and neck.
Neoplasms
Direct and bystander killing of sarcomas by novel cytosine deaminase fusion gene.
Neoplasms
Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model.
Neoplasms
Efficient Prodrug Activator Gene Therapy by Retroviral Replicating Vectors Prolongs Survival in an Immune-Competent Intracerebral Glioma Model.
Neoplasms
Elevated APOBEC mutational signatures implicate chronic injury in etiology of an aggressive head-and-neck squamous cell carcinoma: a case report.
Neoplasms
Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers.
Neoplasms
Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells.
Neoplasms
Enhanced suicide gene therapy by chimeric tumor-specific promoter based on HSF1 transcriptional regulation.
Neoplasms
Enhancement of anti-tumor activity of Newcastle disease virus by the synergistic effect of cytosine deaminase.
Neoplasms
Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase.
Neoplasms
Evaluation of the acute and subchronic toxic effects in mice, rats, and monkeys of the genetically engineered and Escherichia coli cytosine deaminase gene-incorporated Salmonella strain, TAPET-CD, being developed as an antitumor agent.
Neoplasms
Evidence for editing of human papillomavirus DNA by APOBEC3 in benign and precancerous lesions.
Neoplasms
Ex vivo breast cancer cell purging by adenovirus-mediated cytosine deaminase gene transfer and short-term incubation with 5-fluorocytosine completely prevents tumor growth after transplantation.
Neoplasms
Experimental gene therapy for brain tumors using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene with 5-fluorocytosine.
Neoplasms
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
Neoplasms
Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin.
Neoplasms
Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection.
Neoplasms
Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma.
Neoplasms
Fluorine nuclear magnetic resonance, a privileged tool for metabolic studies of fluoropyrimidine drugs.
Neoplasms
Functional Upregulation of the DNA Cytosine Deaminase APOBEC3B by Polyomaviruses.
Neoplasms
Gene therapeutic approach to primary and metastatic brain tumors: I. CD44 variant pre-RNA alternative splicing as a CEPT control element.
Neoplasms
Gene therapy strategies for treating Epstein-Barr virus-associated lymphomas: comparison of two different Epstein-Barr virus-based vectors.
Neoplasms
Generation and characterization of a human single-chain fragment variable (scFv) antibody against cytosine deaminase from Yeast.
Neoplasms
Genetic prodrug activation therapy for breast cancer: A phase I clinical trial of erbB-2-directed suicide gene expression.
Neoplasms
Genetically engineered bifidobacterium as a drug delivery system for systemic therapy of metastatic breast cancer patients.
Neoplasms
Genome-wide mapping of regions preferentially targeted by the human DNA-cytosine deaminase APOBEC3A using uracil-DNA pulldown and sequencing.
Neoplasms
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Neoplasms
Hepatic intra-arterial delivery of a retroviral vector expressing the cytosine deaminase gene, controlled by the CEA promoter and intraperitoneal treatment with 5-fluorocytosine suppresses growth of colorectal liver metastases.
Neoplasms
High APOBEC1 Complementation Factor Expression Positively Modulates the Proliferation, Invasion, and Migration of Endometrial Cancer Cells Through Regulating P53/P21 Signaling Pathway.
Neoplasms
Highly efficient gene delivery for bladder cancers by intravesically administered replication-competent retroviral vectors.
Neoplasms
HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples.
Neoplasms
Human Papillomavirus 16 E7 Stabilizes APOBEC3A Protein by Inhibiting Cullin 2-Dependent Protein Degradation.
Neoplasms
Human papillomavirus E6 triggers upregulation of the antiviral and cancer genomic DNA deaminase APOBEC3B.
Neoplasms
Hypoxia imaging predicts success of hypoxia-induced cytosine deaminase/5-fluorocytosine gene therapy in a murine lung tumor model.
Neoplasms
Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro.
Neoplasms
IFN-? and Lipopolysaccharide Upregulate APOBEC3 mRNA through Different Signaling Pathways.
Neoplasms
Imaging and therapy of tumors induced to express somatostatin receptor by gene transfer using radiolabeled peptides and single chain antibody constructs.
Neoplasms
Imaging expression of cytosine deaminase-herpes virus thymidine kinase fusion gene (CD/TK) expression with [124I]FIAU and PET.
Neoplasms
Immunotherapy of murine prostate cancer using whole tumour cells killed ex vivo by cytosine deaminase/5-fluorocytosine suicide-gene therapy.
Neoplasms
Implantable enzyme capsules for cancer chemotherapy from bakers' yeast cytosine deaminase immobilized on epoxy-acrylic resin and urethane prepolymer.
Neoplasms
Improved cytotoxic effects of Salmonella-producing cytosine deaminase in tumour cells.
Neoplasms
In situ transduction of cytosine deaminase gene followed by systemic use of 5-fluorocytosine inhibits tumor growth and metastasis in orthotopic prostate cancer mouse models.
Neoplasms
In vitro and in vivo effect of 5-FC combined gene therapy with TNF-? and CD suicide gene on human laryngeal carcinoma cell line Hep-2.
Neoplasms
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine.
Neoplasms
In vivo gene regulation in Salmonella spp. by a salicylate-dependent control circuit.
Neoplasms
In vivo suicide gene therapy model using a newly discovered prostate-specific membrane antigen promoter/enhancer: a potential alternative approach to androgen deprivation therapy.
Neoplasms
Increased APOBEC3B Predicts Worse Outcomes in Lung Cancer: A Comprehensive Retrospective Study.
Neoplasms
Increasing specificity of anti-tumor therapy: cytotoxic protein delivery by non-pathogenic clostridia under regulation of radio-induced promoters.
Neoplasms
Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Neoplasms
Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.
Neoplasms
Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-?B.
Neoplasms
Induction of protective immunity against syngeneic rat cancer cells by expression of the cytosine deaminase suicide gene.
Neoplasms
Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3B.
Neoplasms
Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer types.
Neoplasms
Interaction of endothelial progenitor cells expressing cytosine deaminase in tumor tissues and 5-fluorocytosine administration suppresses growth of 5-fluorouracil-sensitive liver cancer in mice.
Neoplasms
Interaction with the CCT chaperonin complex limits APOBEC3A cytidine deaminase cytotoxicity.
Neoplasms
Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.
Neoplasms
Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin.
Neoplasms
Intravenous administration of retroviral replicating vector, toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model.
Neoplasms
KDR promoter can transcriptionally target cytosine deaminase suicide gene to cancer cells of nonendothelial origin.
Neoplasms
Long non-coding RNA ESCCAL-1 promotes esophageal squamous cell carcinoma by down regulating the negative regulator of APOBEC3G.
Neoplasms
Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells.
Neoplasms
LOXL2 Expression Status Is Correlated With Molecular Characterizations of Cervical Carcinoma and Associated With Poor Cancer Survival via Epithelial-Mesenchymal Transition (EMT) Phenotype.
Neoplasms
Maintaining therapeutic activity in the operating room: compatibility of a gamma-retroviral replicating vector with clinical materials and biofluids.
Neoplasms
Management of malignant pleural effusion by suicide gene therapy in advanced stage lung cancer: a case series and literature review.
Neoplasms
Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells.
Neoplasms
Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells.
Neoplasms
Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase.
Neoplasms
Moderate sensitivity of mouse mammary tumour virus to inhibition by human APOBEC3G.
Neoplasms
Molecular Analyses Support the Safety and Activity of Retroviral Replicating Vector Toca 511 in Patients.
Neoplasms
Molecular mechanism and clinical impact of APOBEC3B-catalyzed mutagenesis in breast cancer.
Neoplasms
Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.
Neoplasms
Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1).
Neoplasms
Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma.
Neoplasms
Mutation Processes in 293-Based Clones Overexpressing the DNA Cytosine Deaminase APOBEC3B.
Neoplasms
Nanoplex Delivery of siRNA and Prodrug Enzyme for Multimodality Image-Guided Molecular Pathway Targeted Cancer Therapy.
Neoplasms
Nanoscale bubble delivered YCD-TK/Cx26 gene therapeutic system suppresses tumor growth by inducing necrosis of tumor tissues in mouse Xenograft bladder cancer models.
Neoplasms
Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients.
Neoplasms
Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy.
Neoplasms
Novel cytosine deaminase fusion gene enhances the effect of radiation on breast cancer in bone by reducing tumor burden, osteolysis, and skeletal fracture.
Neoplasms
Nucleotide Weight Matrices Reveal Ubiquitous Mutational Footprints of AID/APOBEC Deaminases in Human Cancer Genomes.
Neoplasms
Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene.
Neoplasms
Overexpression of APOBEC3F in tumor tissues is potentially predictive for poor recurrence-free survival from HBV-related hepatocellular carcinoma.
Neoplasms
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Neoplasms
Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases.
Neoplasms
Pancancer analysis identifies prognostic high-APOBEC1 expression level implicated in cancer in-frame insertions and deletions.
Neoplasms
Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations.
Neoplasms
Pharmacokinetics and tolerance of repeated oral administration of 5-fluorocytosine in healthy dogs.
Neoplasms
Photochemical internalization-mediated nonviral gene transfection: polyamine core-shell nanoparticles as gene carrier.
Neoplasms
Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients.
Neoplasms
Polyomavirus T Antigen Induces APOBEC3B Expression Using an LXCXE-Dependent and TP53-Independent Mechanism.
Neoplasms
Prognostic implication and functional annotations of APOBEC3G expression in patients with Melanoma.
Neoplasms
Pronounced antitumor effects and tumor radiosensitization of double suicide gene therapy.
Neoplasms
Protein-Programmed Accumulation of Yeast Cytosine Deaminase in Cancer Cells in Response to Mock-Hypoxia.
Neoplasms
PSMA-specific theranostic nanoplex for combination of TRAIL gene and 5-FC prodrug therapy of prostate cancer.
Neoplasms
Radiation treatment decreases bone cancer pain through direct effect on tumor cells.
Neoplasms
Radiosensitization and Anti-tumour Effects of Cytosine Deaminase and Thymidine Kinase Fusion Suicide Gene in Human Adenoid Cystic Carcinoma Cells.
Neoplasms
Random mutagenesis and selection of Escherichia coli cytosine deaminase for cancer gene therapy.
Neoplasms
Re: Association of Germline Variants in the APOBEC3 Region with Cancer Risk and Enrichment with APOBEC-Signature Mutations in Tumors.
Neoplasms
Recombinant adenoviral vector containing tumor-specific L-plastin promoter fused to cytosine deaminase gene as a transcription unit: generation and functional test.
Neoplasms
Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy.
Neoplasms
Regional 'pro-drug' gene therapy: intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma.
Neoplasms
Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.
Neoplasms
Replicating adenoviral vector-mediated transfer of a heat-inducible double suicide gene for gene therapy.
Neoplasms
Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity.
Neoplasms
Retroviral Replicating Vectors Deliver Cytosine Deaminase Leading to Targeted 5-Fluorouracil-Mediated Cytotoxicity in Multiple Human Cancer Types.
Neoplasms
Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression.
Neoplasms
Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions.
Neoplasms
Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates.
Neoplasms
Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2'-deoxyzebularine.
Neoplasms
Selective radiosensitization of 9L glioma in the brain transduced with double suicide fusion gene.
Neoplasms
Sensitivity of 5-fluorouracil-resistant cancer cells to adenovirus suicide gene therapy.
Neoplasms
Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G.
Neoplasms
Simultaneous detection of 5-fluorocytosine and 5-fluorouracil in human cells carrying CD/5-FC suicide gene system by using capillary zone electrophoresis.
Neoplasms
Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.
Neoplasms
Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3B.
Neoplasms
Subcutaneous or intrahepatic injection of suicide gene modified tumour cells induces a systemic antitumour response in a metastatic model of colon carcinoma in rats.
Neoplasms
Suboptimal T-cell Therapy Drives a Tumor Cell Mutator Phenotype That Promotes Escape from First-Line Treatment.
Neoplasms
Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and Its Target APOBEC3G and Thereby Pancreatic Cancer Progression.
Neoplasms
Superiority of yeast over bacterial cytosine deaminase for enzyme/prodrug gene therapy in colon cancer xenografts.
Neoplasms
Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus.
Neoplasms
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies.
Neoplasms
Synergistic effects of genetically engineered stem cells expressing cytosine deaminase and interferon-? via their tumor tropism to selectively target human hepatocarcinoma cells.
Neoplasms
Targeted endostatin-cytosine deaminase fusion gene therapy plus 5-fluorocytosine suppresses ovarian tumor growth.
Neoplasms
Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase.
Neoplasms
Targeted Tumor Therapy With a Fusion Protein of an Antiangiogenic Human Recombinant scFv and Yeast Cytosine Deaminase.
Neoplasms
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead.
Neoplasms
The PKC/NF-?B signaling pathway induces APOBEC3B expression in multiple human cancers.
Neoplasms
The potential of 5-fluorocytosine/cytosine deaminase enzyme prodrug gene therapy in an intrahepatic colon cancer model.
Neoplasms
The potential therapeutic gain of radiation-associated gene therapy with the suicide gene cytosine deaminase.
Neoplasms
The RNA editing enzyme APOBEC1 induces somatic mutations and a compatible mutational signature is present in esophageal adenocarcinomas.
Neoplasms
The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.
Neoplasms
The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies.
Neoplasms
The use of cationic liposomes DC-CHOL/DOPE and DDAB/DOPE for direct transfer of Escherichia coli cytosine deaminase gene into growing melanoma tumors.
Neoplasms
Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model.
Neoplasms
Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models.
Neoplasms
Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells.
Neoplasms
Transcriptional regulation of APOBEC3G, a cytidine deaminase that hypermutates human immunodeficiency virus.
Neoplasms
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.
Neoplasms
Transduction of thymidine phosphorylase cDNA facilitates efficacy of cytosine deaminase/5-FC gene therapy for malignant brain tumor.
Neoplasms
Transduction of yeast cytosine deaminase mediated by HIV-1 Tat basic domain into tumor cells induces chemosensitivity to 5-fluorocytosine.
Neoplasms
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Neoplasms
Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy.
Neoplasms
Treatment of human tumor cells by combine gene therapy harnessing plasmids expressing human tumor necrosis factor alpha and bacterial cytosine deaminase suicide gene.
Neoplasms
Treatment of microscopic pulmonary metastases with recombinant autologous tumor vaccine expressing interleukin 6 and Escherichia coli cytosine deaminase suicide genes.
Neoplasms
Treatment of Tumor in Mice by Oral Administration of Cytosine Deaminase Gene Carried in Live Attenuated Salmonella.
Neoplasms
Tumors expressing the cytosine deaminase suicide gene can be eliminated in vivo with 5-fluorocytosine and induce protective immunity to wild type tumor.
Neoplasms
Understanding the regulation of APOBEC3 expression: Current evidence and much to learn.
Neoplasms
Understanding the structural details of APOBEC3-DNA interactions using graph-based representations.
Neoplasms
Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.
Neoplasms
Use of adenoviral vectors to target chemotherapy to tumor vascular endothelial cells suppresses growth of breast cancer and melanoma.
Neoplasms
Use of Epstein-Barr virus nuclear antigen-1 in targeted therapy of EBV-associated neoplasia.
Neoplasms
Usefulness of repeated direct intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy.
Neoplasms
Virally directed cytosine deaminase/5-fluorocytosine gene therapy enhances radiation response in human cancer xenografts.
Neoplasms
When defense turns into attack: Antiviral cytidine deaminases linked to somatic mutagenesis in HPV-associated cancer.
Neoplasms
Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts.
Neoplasms
Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes.
Neoplasms
[Antitumor effect of combined therapy with adenovirus-mediated CD suicide gene and interleukin 2 gene transfer and its immunological mechanism]
Neoplasms
[Apoptosis induced by transferring cytosine deaminase suicide gene into kinds of cancer cells with novel polyamidoamine dendrimers].
Neoplasms
[Combination of ARE and HRE cis- Regulatory Elements Elevates the Activity of Tumor-Specific hTERT Promoter].
Neoplasms
[Hypoxia in malignant tumors the target for clostridial therapeutic gene strategies]
Neoplasms
[Vaccination by suicide gene therapy against a model of hepatic metastasis from colon cancer in the rat]
Neoplasms
[X-ray combined with cytosine deaminase suicide gene therapy enhances killing of colorectal carcinoma cells in vitro]
Neoplasms, Germ Cell and Embryonal
Mouse apolipoprotein B editing complex 3 (APOBEC3) is expressed in germ cells and interacts with dead-end (DND1).
Neoplasms, Germ Cell and Embryonal
Transgenerational epigenetic effects of the Apobec1 cytidine deaminase deficiency on testicular germ cell tumor susceptibility and embryonic viability.
Neoplasms, Squamous Cell
Combined radiation and enzyme/prodrug treatment for head and neck cancer in an orthotopic animal model.
Newcastle Disease
Enhancement of anti-tumor activity of Newcastle disease virus by the synergistic effect of cytosine deaminase.
Obesity
Induction of body weight loss through RNAi-knockdown of APOBEC1 gene expression in transgenic rabbits.
Osteolysis
Novel cytosine deaminase fusion gene enhances the effect of radiation on breast cancer in bone by reducing tumor burden, osteolysis, and skeletal fracture.
Osteolysis
Radiation treatment decreases bone cancer pain through direct effect on tumor cells.
Ovarian Neoplasms
APOBEC3 deletion polymorphism is associated with epithelial ovarian cancer risk among Chinese women.
Ovarian Neoplasms
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.
Ovarian Neoplasms
APOBEC3G expression correlates with T cell infiltration and improved clinical outcomes in high-grade serous ovarian carcinoma.
Ovarian Neoplasms
Gene therapy for ovarian cancer using adenovirus-mediated transfer of cytosine deaminase gene and uracil phosphoribosyltransferase gene directed by MDR1 promoter.
Ovarian Neoplasms
Procaspase-3 enhances the in vitro effect of cytosine deaminase-thymidine kinase disuicide gene therapy on human ovarian cancer.
Ovarian Neoplasms
Targeted endostatin-cytosine deaminase fusion gene therapy plus 5-fluorocytosine suppresses ovarian tumor growth.
Ovarian Neoplasms
The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer.
Ovarian Neoplasms
[Anticancer effects of cytosine deaminase gene/5-fluorocytosine therapies to ovarian cancer in vivo]
Ovarian Neoplasms
[Gene therapy for ovarian cancer by adenovirus-mediated transduction of cytosine deaminase gene in vitro]
Pancreatic Neoplasms
Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice.
Pancreatic Neoplasms
Apoptosis induced by 5-flucytosine in human pancreatic cancer cells genetically modified to express cytosine deaminase.
Pancreatic Neoplasms
Killing effects of cytosine deaminase gene mediated by adenovirus vector on human pancreatic cancer cell lines in vitro.
Pancreatic Neoplasms
Molecular chemotherapy of pancreatic cancer using novel mutant bacterial cytosine deaminase gene.
Pancreatic Neoplasms
Pancreatic tumor mass in a xenograft mouse model is decreased by treatment with therapeutic stem cells following introduction of therapeutic genes.
Pancreatic Neoplasms
Specific gene expression and therapy for pancreatic cancer using the cytosine deaminase gene directed by the rat insulin promoter.
Pancreatic Neoplasms
Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer.
Pancreatic Neoplasms
Sulforaphane Inhibits the Expression of Long Noncoding RNA H19 and Its Target APOBEC3G and Thereby Pancreatic Cancer Progression.
Pancreatic Neoplasms
The virus-induced protein APOBEC3G inhibits anoikis by activation of Akt kinase in pancreatic cancer cells.
Pancreatic Neoplasms
Usefulness of repeated direct intratumoral gene transfer using hemagglutinating virus of Japan-liposome method for cytosine deaminase suicide gene therapy.
Papilloma
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Papillomavirus Infections
APOBEC3 regulates keratinocyte differentiation and expression of Notch3.
Papillomavirus Infections
Correlation of APOBEC3G Polymorphism with Human Papillomavirus (HPV) Persistent Infection and Progression of Cervical Lesions.
Papillomavirus Infections
HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples.
Papillomavirus Infections
Role of the host restriction factor APOBEC3 on papillomavirus evolution.
Peripheral Vascular Diseases
Systemic interleukin-6 responses following administration of adenovirus gene transfer vectors to humans by different routes.
Peritoneal Neoplasms
Cytosine deaminase suicide gene therapy for peritoneal carcinomatosis.
Persistent Infection
Correlation of APOBEC3G Polymorphism with Human Papillomavirus (HPV) Persistent Infection and Progression of Cervical Lesions.
Persistent Infection
Possible footprints of APOBEC3F and/or other APOBEC3 deaminases, but not APOBEC3G, on HIV-1 from patients with acute/early and chronic infections.
Persistent Infection
Vif substitution enables persistent infection of pig-tailed macaques by human immunodeficiency virus type 1.
Persistent Infection
[The associations between polymorphisms of APOBEC3G and different outcomes of persistent HBV infection]
Prostatic Neoplasms
Adenovirus mediated cytosine deaminase gene transduction and 5-fluorocytosine therapy sensitizes mouse prostate cancer cells to irradiation.
Prostatic Neoplasms
Combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice.
Prostatic Neoplasms
Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells.
Prostatic Neoplasms
Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-Beta or Carboxyl Esterase on the Growth of LNCaP Prostate Cancer Cells.
Prostatic Neoplasms
Expression of DNA cytosine deaminase APOBEC3 proteins, a potential source for producing mutations, in gastric, colorectal and prostate cancers.
Prostatic Neoplasms
Hypoxia theranostics of a human prostate cancer xenograft and the resulting effects on the tumor microenvironment.
Prostatic Neoplasms
Improved effects of a double suicide gene system on prostate cancer cells by targeted regulation of prostate-specific membrane antigen promoter and enhancer.
Prostatic Neoplasms
In situ transduction of cytosine deaminase gene followed by systemic use of 5-fluorocytosine inhibits tumor growth and metastasis in orthotopic prostate cancer mouse models.
Prostatic Neoplasms
In vivo suicide gene therapy model using a newly discovered prostate-specific membrane antigen promoter/enhancer: a potential alternative approach to androgen deprivation therapy.
Prostatic Neoplasms
Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.
Prostatic Neoplasms
Phase I study of replication-competent adenovirus-mediated double-suicide gene therapy in combination with conventional-dose three-dimensional conformal radiation therapy for the treatment of newly diagnosed, intermediate- to high-risk prostate cancer.
Prostatic Neoplasms
Prostate-specific suicide gene therapy using the prostate-specific membrane antigen promoter and enhancer.
Prostatic Neoplasms
Sensitization of prostate cancer cell lines to 5-fluorocytosine induced by adenoviral vector carrying a CD transcription unit.
Prostatic Neoplasms
Targeted enzyme prodrug therapy for metastatic prostate cancer - a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase.
Rectal Neoplasms
Combined liposome-mediated cytosine deaminase gene therapy with radiation in killing rectal cancer cells and xenografts in athymic mice.
Rectal Neoplasms
[Antitumor effects of cytosine deaminase and HSV-tk double suicide gene with adenovirus mediation on rectal cancer cells]
Rectal Neoplasms
[Three-pronged approach to treat rectal cancer: liposome transfer cytosine deaminase gene, ionizing radiation and dendritic cells]
Retroviridae Infections
Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.
Retroviridae Infections
Comparative analysis of the gene-inactivating potential of retroviral restriction factors APOBEC3F and APOBEC3G.
Retroviridae Infections
Early events in retrovirus XMRV infection of the wild-derived mouse Mus pahari.
Retroviridae Infections
Human APOBEC3 proteins, retrovirus restriction, and HIV drug resistance.
Retroviridae Infections
IFN-? treatment inhibits acute Friend retrovirus replication primarily through the antiviral effector molecule Apobec3.
Retroviridae Infections
Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection.
Retroviridae Infections
In vivo hypermutation of xenotropic murine leukemia virus-related virus DNA in peripheral blood mononuclear cells of rhesus macaque by APOBEC3 proteins.
Retroviridae Infections
Induction of APOBEC3 in vivo causes increased restriction of retrovirus infection.
Retroviridae Infections
Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance.
Retroviridae Infections
Loci Polymorphisms of the APOBEC3G Gene in HIV Type 1-Infected Brazilians.
Retroviridae Infections
Repression of porcine endogenous retrovirus infection by human APOBEC3 proteins.
Rhabdomyosarcoma
Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum.
Rubella
Unusual nucleotide content of Rubella virus genome as a consequence of biased RNA-editing: comparison with Alphaviruses.
Sarcoma
Radiation treatment decreases bone cancer pain through direct effect on tumor cells.
Sarcoma, Avian
Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins.
Simian Acquired Immunodeficiency Syndrome
APOBEC3G Polymorphism as a Selective Barrier to Cross-Species Transmission and Emergence of Pathogenic SIV and AIDS in a Primate Host.
Squamous Cell Carcinoma of Head and Neck
APOBEC mutagenesis is tightly linked to the immune landscape and immunotherapy biomarkers in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Oncolysis using herpes simplex virus type 1 engineered to express cytosine deaminase and a fusogenic glycoprotein for head and neck squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
PYHIN genes as potential biomarkers for prognosis of human papillomavirus-positive or -negative head and neck squamous cell carcinomas.
Squamous Cell Carcinoma of Head and Neck
Transferrin lipoplex-mediated suicide gene therapy of oral squamous cell carcinoma in an immunocompetent murine model and mechanisms involved in the antitumoral response.
Starvation
Transcriptional regulation of APOBEC3G, a cytidine deaminase that hypermutates human immunodeficiency virus.
Stomach Neoplasms
APOBEC-mediated DNA alterations: A possible new mechanism of carcinogenesis in EBV-positive gastric cancer.
Stomach Neoplasms
Cytosine deaminase-producing human mesenchymal stem cells mediate an antitumor effect in a mouse xenograft model.
Stomach Neoplasms
In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.
Stomach Neoplasms
Promoter selection for the cytosine deaminase suicide gene constructs in gastric cancer.
Stomach Neoplasms
Stem cells with fused gene expression of cytosine deaminase and interferon-? migrate to human gastric cancer cells and result in synergistic growth inhibition for potential therapeutic use.
Stomach Neoplasms
Tumor-specific gene expression in carcinoembryonic antigen--producing gastric cancer cells using adenovirus vectors.
Superinfection
The effects of MAPK p38? on AZT resistance against reactivating HIV-1 replication in ACH2 cells.
Thyroid Carcinoma, Anaplastic
Antithyroid cancer effects of human neural stem cells expressing therapeutic genes on anaplastic thyroid cancer cells.
Thyroid Neoplasms
Bystander cytotoxicity in human medullary thyroid carcinoma cells mediated by fusion yeast cytosine deaminase and 5-fluorocytosine.
Tumor Virus Infections
Expression of murine APOBEC3 alleles in different mouse strains and their effect on mouse mammary tumor virus infection.
Urinary Bladder Neoplasms
APOBEC3B Activity Is Prevalent in Urothelial Carcinoma Cells and Only Slightly Affected by LINE-1 Expression.
Urinary Bladder Neoplasms
Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model.
Uterine Cervical Neoplasms
Anticancer effects of the engineered stem cells transduced with therapeutic genes via a selective tumor tropism caused by vascular endothelial growth factor toward HeLa cervical cancer cells.
Uterine Cervical Neoplasms
APOBEC3A and 3C decrease human papillomavirus 16 pseudovirion infectivity.
Uterine Cervical Neoplasms
Correlation of APOBEC3G Polymorphism with Human Papillomavirus (HPV) Persistent Infection and Progression of Cervical Lesions.
Vaccinia
Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression.
Vaccinia
Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene.
Vaccinia
Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment.
Vaccinia
Regional versus systemic delivery of recombinant vaccinia virus as suicide gene therapy for murine liver metastases.
Vaccinia
Systemic administration of a recombinant vaccinia virus expressing the cytosine deaminase gene and subsequent treatment with 5-fluorocytosine leads to tumor-specific gene expression and prolongation of survival in mice.
Vaccinia
Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus.
Vaccinia
Vectorized Gene Therapy of Liver Tumors: Proof of Concept of TG4023 (MVA-FCU1) in Combination with Flucytosine.
Vaccinia
Vectorized gene therapy of liver tumors: proof-of-concept of TG4023 (MVA-FCU1) in combination with flucytosine.
Viremia
APOBEC3F and APOBEC3G mRNA levels do not correlate with human immunodeficiency virus type 1 plasma viremia or CD4+ T-cell count.
Viremia
APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression.
Viremia
Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in Friend virus-infected mice.
Viremia
Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional BAFF-R.
Viremia
Population level analysis of human immunodeficiency virus type 1 hypermutation and its relationship with APOBEC3G and vif genetic variation.
Viremia
Role of APOBEC3G/F-mediated hypermutation in the control of human immunodeficiency virus type 1 in elite suppressors.
Viremia
Short-term Treatment With Interferon Alfa Diminishes Expression of HIV-1 and Reduces CD4+ T-Cell Activation in Patients Coinfected With HIV and Hepatitis C Virus and Receiving Antiretroviral Therapy.
Virus Diseases
A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection.
Virus Diseases
AID and APOBEC deaminases: balancing DNA damage in epigenetics and immunity.
Virus Diseases
Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator.
Virus Diseases
APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells.
Virus Diseases
Association between polymorphisms of the APOBEC3G gene and chronic hepatitis B viral infection and hepatitis B virus-related hepatocellular carcinoma.
Virus Diseases
Beyond SHM and CSR: AID and related cytidine deaminases in the host response to viral infection.
Virus Diseases
Germline APOBEC3B deletion is associated with breast cancer risk in an Asian multi-ethnic cohort and with immune cell presentation.
Virus Diseases
HPV induction of APOBEC3 enzymes mediate overall survival and response to cisplatin in head and neck cancer.
Virus Diseases
Hypermutation in the E2 gene of human papillomavirus type 16 in cervical intraepithelial neoplasia.
Virus Diseases
In Vivo Examination of Mouse APOBEC3- and Human APOBEC3A- and APOBEC3G-Mediated Restriction of Parvovirus and Herpesvirus Infection in Mouse Models.
Virus Diseases
Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.
Virus Diseases
Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.
Virus Diseases
Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all.
Virus Diseases
Non-lytic Lymphocytes Engineered to Express Virus-specific T-cell Receptors Limit HBV Infection by Activating APOBEC3.
Virus Diseases
Pan-cancer transcriptomic analysis dissects immune and proliferative functions of APOBEC3 cytidine deaminases.
Virus Diseases
Restriction of feline retroviruses: lessons from cat APOBEC3 cytidine deaminases and TRIM5alpha proteins.
Virus Diseases
Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor.
Virus Diseases
Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity.
Virus Diseases
The role of cytidine deaminases on innate immune responses against human viral infections.
Virus Diseases
The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities.
Virus Diseases
Understanding the regulation of APOBEC3 expression: Current evidence and much to learn.
Wilms Tumor
[Therapeutic effect of 5-fluorocytosine on cytosine deaminase gene transduced Wilms' tumor xenograft in nude mice]
Zoonoses
Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion.
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