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Information on EC 3.5.1.6 - beta-ureidopropionase and Organism(s) Arabidopsis thaliana and UniProt Accession Q8H183

for references in articles please use BRENDA:EC3.5.1.6
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IUBMB Comments
The animal enzyme also acts on beta-ureidoisobutyrate.
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This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q8H183
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Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
beta-ureidopropionase, beta-alanine synthase, betaas, 3-ureidopropionase, betaupase, beta-up, bup-1, n-carbamoyl-beta-alanine amidohydrolase, betaup, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
beta-ureidopropionase
-
beta-alanine synthase
-
-
N-carbamoyl-beta-alanine amidohydrolase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of linear amides
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
N-carbamoyl-beta-alanine amidohydrolase
The animal enzyme also acts on beta-ureidoisobutyrate.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-27-4
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
show the reaction diagram
-
-
-
?
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
show the reaction diagram
-
-
-
-
?
N-carbamoyl-beta-aminoisobutyrate + H2O
beta-aminoisobutyrate + CO2 + NH3
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
N-carbamoyl-beta-alanine + H2O
beta-alanine + CO2 + NH3
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.008
N-Carbamoyl-beta-alanine
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
expression anaylsis, overview
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
PYD3 is involved in the reductive pathway for the degradation of pyrimidine nucleotides, functional and mutational analysis of the catabolic pathway, overview
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
BUP1_ARATH
408
0
45553
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45500
-
10 * 45500
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homodecamer
-
10 * 45500
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
construction of a T-DNA knockout mutant of gene PYD3, the mutant exhibits no obvious phenotype under optimal growing conditions, but the pyd3 mutant is unable to catabolize [2-14C]-uracil or to grow on uracil as the sole nitrogen source
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression of GFP-tagged PYD3 in Arabdiopsis thaliana via Agrobacterium-mediated transformation using the floral dip method. Quantitative real-time RT-PCR analysis of PYD expression in wild-type and pyd mutants, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Schnackerz, K.D.; Dobritzsch, D.
Amidohydrolases of the reductive pyrimidine catabolic pathway: Purification, characterization, structure, reaction mechanisms and enzyme deficiency
Biochim. Biophys. Acta
1784
431-444
2008
Arabidopsis thaliana, Bos taurus, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster, Euglena gracilis, Homo sapiens, Lachancea kluyveri, Pseudomonas putida, Rattus norvegicus, Zea mays
Manually annotated by BRENDA team
Zrenner, R.; Riegler, H.; Marquard, C.R.; Lange, P.R.; Geserick, C.; Bartosz, C.E.; Chen, C.T.; Slocum, R.D.
A functional analysis of the pyrimidine catabolic pathway in Arabidopsis
New Phytol.
183
117-132
2009
Arabidopsis thaliana (Q8H183)
Manually annotated by BRENDA team