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Information on EC 3.5.1.122 - protein N-terminal glutamine amidohydrolase

for references in articles please use BRENDA:EC3.5.1.122
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IUBMB Comments
This enzyme participates in the eukaryotic ubiquitin-dependent Arg/N-end rule pathway of protein degradation, promoting the turnover of intracellular proteins that initiate with Met-Gln. Following the acetylation and removal of the initiator methionine, the exposed N-terminal glutamine is deaminated, resulting in its conversion to L-glutamate. The latter serves as a substrate for EC 2.3.2.8, arginyltransferase, making the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule.
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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
N-terminal L-glutaminyl-[protein]
+
=
N-terminal L-glutamyl-[protein]
+
Synonyms
ntaq1, c8orf32, hntaq1, cg8253, wdyhv1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3
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PATHWAY SOURCE
PATHWAYS
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