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Information on EC 3.5.1.110 - ureidoacrylate amidohydrolase and Organism(s) Escherichia coli and UniProt Accession P75897

for references in articles please use BRENDA:EC3.5.1.110
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EC Tree
IUBMB Comments
The enzyme participates in the Rut pyrimidine catabolic pathway.
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This record set is specific for:
Escherichia coli
UNIPROT: P75897
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The taxonomic range for the selected organisms is: Escherichia coli
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Reaction Schemes
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(Z)-3-ureidoacrylate
+
H2O
=
(Z)-3-aminoacrylate
+
CO2
+
NH3
(Z)-3-ureidoacrylate
+
=
(Z)-3-aminoacrylate
+
+
(Z)-2-methylureidoacrylate
+
H2O
=
(Z)-2-methylaminoacrylate
+
CO2
+
NH3
(Z)-2-methylureidoacrylate
+
=
(Z)-2-methylaminoacrylate
+
+
Synonyms
(Z)-3-ureidoacrylate peracid amidohydrolase, peroxyureidoacrylate/ureidoacrylate amidohydrolase, RutB, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
(Z)-3-ureidoacrylate peracid amidohydrolase
-
-
-
-
peroxyureidoacrylate/ureidoacrylate amidohydrolase
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
(Z)-3-ureidoacrylate amidohydrolase
The enzyme participates in the Rut pyrimidine catabolic pathway.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
ureidoacrylate peracid + H2O
peroxyaminoacrylate + NH3 + CO2
show the reaction diagram
-
-
-
?
ureidoacrylate + H2O
aminoacrylate + NH3 + CO2
show the reaction diagram
-
-
-
-
?
ureidoacrylate peracid + H2O
peroxyaminoacrylate + NH3 + CO2
show the reaction diagram
-
-
-
-
?
additional information
?
-
in vitro RutB cleaves ureidoacrylate hydrolytically to release 2 mol of ammonium, malonic semialdehyde, and carbon dioxide
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ureidoacrylate peracid + H2O
peroxyaminoacrylate + NH3 + CO2
show the reaction diagram
-
-
-
?
ureidoacrylate + H2O
aminoacrylate + NH3 + CO2
show the reaction diagram
-
-
-
-
?
ureidoacrylate peracid + H2O
peroxyaminoacrylate + NH3 + CO2
show the reaction diagram
-
-
-
-
?
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
K-12, gene rutB
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
metabolism
functions of enzymes encoded in the rut gene cluster, overview
metabolism
-
RutB of the rut gene cluster is involved in the uracil catabolism, overview
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
construction of diverse rutB-deficient strains, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Parales, R.; Ingraham, J.
The surprising Rut pathway: An unexpected way to derive nitrogen from pyrimidines
J. Bacteriol.
192
4086-4088
2010
Escherichia coli
Manually annotated by BRENDA team
Kim, K.S.; Pelton, J.G.; Inwood, W.B.; Andersen, U.; Kustu, S.; Wemmer, D.E.
The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems
J. Bacteriol.
192
4089-4102
2010
Escherichia coli (P75897), Escherichia coli JW5139 (P75897)
Manually annotated by BRENDA team