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Information on EC 3.4.24.B17 - FtsH endopeptidase and Organism(s) Thermotoga maritima and UniProt Accession Q9WZ49

for references in articles please use BRENDA:EC3.4.24.B17
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B17 FtsH endopeptidase
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This record set is specific for:
Thermotoga maritima
UNIPROT: Q9WZ49
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Word Map
The taxonomic range for the selected organisms is: Thermotoga maritima
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
proteolytic degradation of proteins
Synonyms
t.ftsh, mtftsh, cell division protein ftsh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CAS REGISTRY NUMBER
COMMENTARY hide
171904-23-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
casein + H2O
?
show the reaction diagram
caseinolytic activity is not stimulated by ATP
-
-
?
protein D1 + H2O
?
show the reaction diagram
-
-
-
?
protein D2 + H2O
?
show the reaction diagram
-
-
-
?
protein F0a + H2O
?
show the reaction diagram
-
-
-
?
protein GgpS + H2O
?
show the reaction diagram
-
-
-
?
protein GlnK + H2O
?
show the reaction diagram
-
-
-
?
protein KdtA + H2O
?
show the reaction diagram
-
-
-
?
protein LpxC + H2O
?
show the reaction diagram
-
-
-
?
protein MgtC + H2O
?
show the reaction diagram
-
-
-
?
protein RpoH + H2O
?
show the reaction diagram
-
-
-
?
protein SecY + H2O
?
show the reaction diagram
-
-
-
?
protein YccA + H2O
?
show the reaction diagram
-
-
-
?
superoxide response protein + H2O
?
show the reaction diagram
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stres
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
microbatch methodFtsH is expressed in Escherichia coli as a construct (residues 146-610) lacking the two transmembrane helices and purified
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
FtsH is expressed in Escherichia coli as a construct (residues 146-610) lacking the two transmembrane helices
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Bieniossek, C.; Schalch, T.; Bumann, M.; Meister, M.; Meier, R.; Baumann, U.
The molecular architecture of the metalloprotease FtsH
Proc. Natl. Acad. Sci. USA
103
3066-3071
2006
Thermotoga maritima (Q9WZ49)
Manually annotated by BRENDA team
Langklotz, S.; Baumann, U.; Narberhaus, F.
Structure and function of the bacterial AAA protease FtsH
Biochim. Biophys. Acta
1823
40-48
2012
Aquifex aeolicus, Helicobacter pylori, Thermotoga maritima (Q9WZ49), Thermus thermophilus
Manually annotated by BRENDA team