Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.24.B17 - FtsH endopeptidase and Organism(s) Aquifex aeolicus and UniProt Accession O67077

for references in articles please use BRENDA:EC3.4.24.B17
preliminary BRENDA-supplied EC number
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B17 FtsH endopeptidase
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Aquifex aeolicus
UNIPROT: O67077
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Aquifex aeolicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
proteolytic degradation of proteins
Synonyms
t.ftsh, mtftsh, cell division protein ftsh, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CAS REGISTRY NUMBER
COMMENTARY hide
171904-23-7
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
protein D1 + H2O
?
show the reaction diagram
-
-
-
-
?
protein D2 + H2O
?
show the reaction diagram
-
-
-
-
?
protein F0a + H2O
?
show the reaction diagram
-
-
-
-
?
protein GgpS + H2O
?
show the reaction diagram
-
-
-
-
?
protein GlnK + H2O
?
show the reaction diagram
-
-
-
-
?
protein KdtA + H2O
?
show the reaction diagram
-
-
-
-
?
protein LpxC + H2O
?
show the reaction diagram
-
-
-
-
?
protein MgtC + H2O
?
show the reaction diagram
-
-
-
-
?
protein RpoH + H2O
?
show the reaction diagram
-
-
-
-
?
protein SecY + H2O
?
show the reaction diagram
-
-
-
-
?
protein YccA + H2O
?
show the reaction diagram
-
-
-
-
?
superoxide response protein + H2O
?
show the reaction diagram
-
-
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
Uniprot
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
-
inner membrane
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
-
FtsH plays a role in phage lambda infection, serves a dual function in regulation of lipopolysaccharide biosynthesis and is involved in survival upon stress conditions like heat shock or osmotic stres
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
homohexamer
-
-
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystallization of a fragment, covering the entire protease domain (residues 405-634), crystals are grown in a buffer solution containing 0.1 M MES (pH 6.0) and 5% PEG8K, at 20°C, using vapor-diffusion technique. 2.79 resolution
crystallization of the soluble cytosolic region of FtsH (residues 126-624), crystals are grown in a buffer solution containing 0.1 M Tris-HCl (pH 7.2) and 1% PEG8K, 0.2 mM Zn acetate, 5 mM MgCl2 and 2.5 mM ADP at 20°C, using vapor-diffusion technique. 2.79 A resolution
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Suno, R.; Niwa, H.; Tsuchiya, D.; Zhang, X.; Yoshida, M.; Morikawa, K.
Structure of the whole cytosolic region of ATP-dependent protease FtsH
Mol. Cell
22
575-585
2006
Aquifex aeolicus (O67077)
Manually annotated by BRENDA team
Langklotz, S.; Baumann, U.; Narberhaus, F.
Structure and function of the bacterial AAA protease FtsH
Biochim. Biophys. Acta
1823
40-48
2012
Aquifex aeolicus, Helicobacter pylori, Thermotoga maritima (Q9WZ49), Thermus thermophilus
Manually annotated by BRENDA team