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Information on EC 3.4.24.B11 - ADAMTS1 endopeptidase and Organism(s) Rattus norvegicus and UniProt Accession Q9WUQ1

for references in articles please use BRENDA:EC3.4.24.B11
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B11 ADAMTS1 endopeptidase
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This record set is specific for:
Rattus norvegicus
UNIPROT: Q9WUQ1
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Tetrapoda
Reaction Schemes
proteolytic degradation of proteins
Synonyms
angiogenesis inhibitor, adamts1, adam metallopeptidase, meth-1, meth1, xadamts1, adam-ts1, xenopus ortholog of adamts1, adam-metallopeptidase with thrombospondin type 1 motifs-1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
a disintegrin and metalloproteinase with thrombospondin motifs 1
-
M12.222
Merops-ID
a disintegrin and metalloproteinase with thrombospondin motifs-1
-
-
ADAMTS-1
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
CAS REGISTRY NUMBER
COMMENTARY hide
241475-68-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
proteins + H2O
peptides
show the reaction diagram
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
proteins + H2O
peptides
show the reaction diagram
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
tissue inhibitor of metalloproteinases-3
-
TIMP-3
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
down regulation in endothelial cells in cirrhotic rats
Manually annotated by BRENDA team
-
tissue containing a 62 kDa fragment of ADAMTS-1
Manually annotated by BRENDA team
-
basal lamina of epithelium of intestine, nasal cavity, choroids plexus, skin and intracellular storage vesicles
Manually annotated by BRENDA team
-
tissue containing a 62 kDa fragment of ADAMTS-1
Manually annotated by BRENDA team
-
tissue containing a 62 kDa fragment of ADAMTS-1
Manually annotated by BRENDA team
-
tissue containing a 62 kDa fragment of ADAMTS-1
Manually annotated by BRENDA team
-
tissue containing a 62 kDa fragment of ADAMTS-1
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ATS1_RAT
967
0
105706
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
110000
-
SDS-PAGE
62000
-
SDS-PAGE, fragment of ADAMTS-1
95000
-
SDS-PAGE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
tumor growth inhibitor
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Mus musculus (P97857), Rattus norvegicus (Q9WUQ1)
Manually annotated by BRENDA team
Guenther, W.; Skaftnesmo, K.O.; Arnold, H.; Bjerkvig, R.; Terzis, A.J.
Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development
Acta Histochem.
107
121-131
2005
Rattus norvegicus
Manually annotated by BRENDA team
Cross, A.K.; Haddock, G.; Stock, C.J.; Allan, S.; Surr, J.; Bunning, R.A.; Buttle, D.J.; Woodroofe, M.N.
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes
Brain Res.
1088
19-30
2006
Rattus norvegicus
Manually annotated by BRENDA team
Basile, D.P.; Fredrich, K.; Chelladurai, B.; Leonard, E.C.; Parrish, A.R.
Renal ischemia reperfusion inhibits VEGF expression and induces ADAMTS-1, a novel VEGF inhibitor
Am. J. Physiol. Renal Physiol.
294
F928-F936
2008
Rattus norvegicus
Manually annotated by BRENDA team
Diamantis, I.; Luethi, M.; Hoesli, M.; Reichen, J.
Cloning of the rat ADAMTS-1 gene and its down regulation in endothelial cells in cirrhotic rats
Liver
20
165-172
2000
Rattus norvegicus (Q9WUQ1)
Manually annotated by BRENDA team