Disease on EC 3.4.24.82 - ADAMTS-4 endopeptidase
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Abortion, Spontaneous
Decreased ADAMTS-1, -9 and -20 levels in women with endometrial polyps: a possible link between extracellular matrix proteases and endometrial pathologies
Abscess
Histopathologic and immunohistochemical investigations of abscess fluid cells formed in the palato-gingival area.
Acute Coronary Syndrome
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Acute Coronary Syndrome
Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome.
Acute Coronary Syndrome
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice.
adamts-4 endopeptidase deficiency
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Alzheimer Disease
The metalloprotease ADAMTS4 generates N-truncated A?4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
Amyotrophic Lateral Sclerosis
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
Amyotrophic Lateral Sclerosis
Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
Aneurysm
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Aneurysm
Genetic correlates of wall shear stress in a patient-specific 3D-printed cerebral aneurysm model.
Aneurysm, Dissecting
Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection.
Angina Pectoris
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Angina, Stable
Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina.
Angina, Unstable
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Aortic Aneurysm
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Aortic Aneurysm, Abdominal
MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.
Aortic Aneurysm, Thoracic
ADAMTS-1 and ADAMTS-4 levels are elevated in thoracic aortic aneurysms and dissections.
Aortic Rupture
Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
Arteriovenous Fistula
Adventitial delivery of lentivirus-shRNA-ADAMTS-1 reduces venous stenosis formation in arteriovenous fistula.
Arteriovenous Fistula
Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency.
Arthritis
ADAMTS-1-knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo.
Arthritis
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Arthritis
Adaptor proteins and Ras synergistically regulate IL-1-induced ADAMTS-4 expression in human chondrocytes.
Arthritis
Inhibition of ADAMTS4 (aggrecanase-1) by tissue inhibitors of metalloproteinases (TIMP-1, 2, 3 and 4).
Arthritis
Interleukin-4 antagonizes oncostatin M and transforming growth factor beta-induced responses in articular chondrocytes.
Arthritis
Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (Aggrecanase 1).
Arthritis
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family.
Arthritis
The thrombospondin motif of aggrecanase-1 (ADAMTS-4) is critical for aggrecan substrate recognition and cleavage.
Arthritis, Rheumatoid
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
Arthritis, Rheumatoid
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Arthritis, Rheumatoid
Identification of Potent Virtual Leads Specific to S1' Loop of ADAMTS4: Pharmacophore Modeling, 3D-QSAR, Molecular Docking and Dynamic Studies.
Arthritis, Rheumatoid
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid.
Arthritis, Rheumatoid
The low binding affinity of ADAMTS4 for citrullinated fibronectin may contribute to the destruction of joint cartilage in rheumatoid arthritis.
Atherosclerosis
A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes.
Atherosclerosis
ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.
Atherosclerosis
Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome.
Atherosclerosis
Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice.
Atherosclerosis
Regulation of ADAMTS-1, -4 and -5 expression in human macrophages: Differential regulation by key cytokines implicated in atherosclerosis and novel synergism between TL1A and IL-17.
Atherosclerosis
Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.
Atherosclerosis
The expression of a disintegrin and metalloproteinase with thrombospondin motifs 4 in human macrophages is inhibited by the anti-atherogenic cytokine transforming growth factor-? and requires Smads, p38 mitogen-activated protein kinase and c-Jun.
Autoimmune Diseases
The association of clinical phenotypes to known AD/FTD genetic risk loci and their inter-relationship.
Bone Resorption
Histopathologic and immunohistochemical investigations of abscess fluid cells formed in the palato-gingival area.
Brain Injuries
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.
Brain Injuries, Traumatic
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Breast Neoplasms
Cleavage of Fibulin-2 by the aggrecanases ADAMTS-4 and ADAMTS-5 contributes to the tumorigenic potential of breast cancer cells.
Breast Neoplasms
Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion.
Breast Neoplasms
Dysregulated expression of adamalysin-thrombospondin genes in human breast carcinoma.
Breast Neoplasms
miR?365 overexpression promotes cell proliferation and invasion by targeting ADAMTS-1 in breast cancer.
Carcinoma
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.
Carcinoma
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Carcinoma, Hepatocellular
Expression of ADAMTS-1, ADAMTS-4, ADAMTS-5 and TIMP3 by hepatocellular carcinoma cell lines.
Carcinoma, Lewis Lung
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Cardiovascular Diseases
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
Cardiovascular Diseases
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Cardiovascular Diseases
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Carotid Stenosis
Relationship between ADAMTS4 and carotid atherosclerotic plaque vulnerability in humans.
Central Nervous System Diseases
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
Chondrosarcoma
Activation of the proteolytic activity of ADAMTS4 (aggrecanase-1) by C-terminal truncation.
Chondrosarcoma
ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.
Chondrosarcoma
Carnosol and Related Substances Modulate Chemokine and Cytokine Production in Macrophages and Chondrocytes.
Chondrosarcoma
Correlation between the histological grade of chondrosarcoma and the expression of MMPs, ADAMTSs and TIMPs.
Chondrosarcoma
Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
Colonic Neoplasms
ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function.
Colorectal Neoplasms
ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer.
Colorectal Neoplasms
Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages.
Corneal Neovascularization
Protective Roles of the Fractalkine/CX3CL1-CX3CR1 Interactions in Alkali-Induced Corneal Neovascularization through Enhanced Antiangiogenic Factor Expression.
Coronary Artery Disease
A novel association between TGFb1 and ADAMTS4 in coronary artery disease: A new potential mechanism in the progression of atherosclerosis and diabetes.
Coronary Artery Disease
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Coronary Artery Disease
Association of serum a disintegrin and metalloproteinase with thrombospodin motif 4 levels with the presence and severity of coronary artery disease.
Coronary Stenosis
Elevated level of ADAMTS4 in plasma and peripheral monocytes from patients with acute coronary syndrome.
Diabetes, Gestational
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Down Syndrome
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Encephalomyelitis
Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Differential expression of ADAMTS-1, -4, -5 and TIMP-3 in rat spinal cord at different stages of acute experimental autoimmune encephalomyelitis.
Epilepsy, Rolandic
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Facial Hemiatrophy
Changes in Cutaneous Gene Expression after Microvascular Free Tissue Transfer in Parry-Romberg Syndrome.
Fibrosarcoma
ADAMTS-1 disrupts HGF/c-MET signaling and HGF-stimulated cellular processes in fibrosarcoma.
Glioblastoma
Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas.
Heart Diseases
Expression of ADAMTS-1 mRNA in myocardium of viral heart disease mice and its clinical significance.
Hydronephrosis
A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy.
Hyperalgesia
Dependence of monocyte chemoattractant protein 1 induced hyperalgesia on the isolectin B4-binding protein versican.
Hyperalgesia
GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.
Hyperparathyroidism, Primary
Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism.
Hyperparathyroidism, Primary
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
Hypertension
Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection.
Hypertension, Pulmonary
Effects of baicalin on collagen ? and collagen ??? expression in pulmonary arteries of rats with hypoxic pulmonary hypertension.
Hypogonadism
The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism.
Infarction, Middle Cerebral Artery
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.
Infarction, Middle Cerebral Artery
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Infections
[EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY].
Insulin Resistance
The impact of parathyroidectomy on serum ADAMTS1, ADAMTS4 levels, insulin resistance, and subclinical cardiovascular disease in primary hyperparathyroidism.
Insulin Resistance
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Intervertebral Disc Degeneration
APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix.
Intervertebral Disc Degeneration
Assessment of the Matrix Degenerative Effects of MMP-3, ADAMTS-4 and HTRA1 injected into a bovine Intervertebral Disc Organ Culture Model.
Intervertebral Disc Degeneration
Association between ADAMTS-4 gene polymorphism and lumbar disc degeneration in Chinese Han population.
Intervertebral Disc Degeneration
Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration.
Intervertebral Disc Degeneration
Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation.
Intervertebral Disc Degeneration
Gallic acid inhibits the release of ADAMTS4 in nucleus pulposus cells by inhibiting p65 phosphorylation and acetylation of the NF-?B signaling pathway.
Intervertebral Disc Degeneration
Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-?B.
Intervertebral Disc Degeneration
Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration.
Intervertebral Disc Degeneration
Interleukin-1? exacerbates the catabolic effects of human nucleus pulposus cells through activation of the Nuclear Factor kappa B signaling pathway under hypoxic conditions.
Intervertebral Disc Degeneration
The imbalance between TIMP3 and matrix-degrading enzymes plays an important role in intervertebral disc degeneration.
Intervertebral Disc Degeneration
[Electroacupuncture down-regulates expression of ADAMTS-4 of intervertebral disc in rats with lumbar intervertebral disc degeneration].
Intervertebral Disc Displacement
Expression of ADAMTS-4 (aggrecanase-1) and possible involvement in regression of lumbar disc herniation.
Intervertebral Disc Displacement
Transcript levels of major MMPs and ADAMTS-4 in relation to the clinicopathological profile of patients with lumbar disc herniation.
Ischemic Stroke
[Association of ADAMTS-1 gene polymorphisms with ischemic stroke caused by large artery atherosclerosis].
Joint Diseases
ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.
Joint Diseases
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Joint Diseases
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites.
Joint Diseases
Characterization of 5'-flanking region of human aggrecanase-1 (ADAMTS4) gene.
Joint Diseases
Detection of ADAMTS-4 activity using a fluorogenic peptide-conjugated Au nanoparticle probe in human knee synovial fluid.
Joint Diseases
MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.
Joint Diseases
The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model.
Joint Diseases
TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.
Joint Instability
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
Kashin-Beck Disease
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Leiomyoma
Versican Proteolysis by ADAMTS Proteases and its Influence on Sex Steroid Receptor Expression in Uterine Leiomyoma.
Leukemia
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Lung Neoplasms
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Melanoma
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Melanoma, Experimental
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Multiple Sclerosis
Expression of ADAMTS-1, -4, -5 and TIMP-3 in normal and multiple sclerosis CNS white matter.
Myocardial Infarction
ADAMTS4 level in patients with stable coronary artery disease and acute coronary syndromes.
Myocardial Infarction
Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina.
Myocardial Infarction
The quantification of ADAMTS4 and 8 expression and selection of reference genes for quantitative real-time PCR analysis in myocardial infarction.
Myocarditis
ADAMTS-1 contributes to the antifibrotic effect of captopril by accelerating the degradation of type I collagen in chronic viral myocarditis.
Myocarditis
[Association between myocardial ADAMTS-1 expression and myocardial fibrosis in a murine model of viral myocarditis]
Neoplasm Metastasis
Discrepancy of biologic behavior influenced by bone marrow derived cells in lung cancer.
Neoplasm Metastasis
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Neoplasm Metastasis
The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential.
Neoplasms
ADAMTS-1 metalloproteinase promotes tumor development through the induction of a stromal reaction in vivo.
Neoplasms
ADAMTS-9 is synergistically induced by interleukin-1beta and tumor necrosis factor alpha in OUMS-27 chondrosarcoma cells and in human chondrocytes.
Neoplasms
ADAMTS4 and its proteolytic fragments differentially affect melanoma growth and angiogenesis in mice.
Neoplasms
ADAMTS4 is upregulated in colorectal cancer and could be a useful prognostic indicator of colorectal cancer.
Neoplasms
Anti-Inflammatory Effects of Conditioned Medium of Periodontal Ligament-Derived Stem Cells on Chondrocytes, Synoviocytes, and Meniscus Cells.
Neoplasms
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Neoplasms
C/EBP? and Nuclear Factor of Activated T Cells Differentially Regulate Adamts-1 Induction by Stimuli Associated with Vascular Remodeling.
Neoplasms
CD11c+ macrophages and levels of TNF-? and MMP-3 are increased in synovial and adipose tissues of osteoarthritic mice with hyperlipidemia.
Neoplasms
Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans.
Neoplasms
Cytokine and catabolic enzyme expression in synovium, synovial fluid and articular cartilage of naturally osteoarthritic equine carpi.
Neoplasms
Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: Sustained release of a local antiinflammatory therapeutic.
Neoplasms
Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories.
Neoplasms
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus.
Neoplasms
Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC).
Neoplasms
Full-length ADAMTS-1 and the ADAMTS-1 fragments display pro- and antimetastatic activity, respectively.
Neoplasms
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Neoplasms
High-density lipoprotein subfraction 3 decreases ADAMTS-1 expression induced by lipopolysaccharide and tumor necrosis factor-alpha in human endothelial cells.
Neoplasms
Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer.
Neoplasms
Interleukin-6 upregulates expression of ADAMTS-4 in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Neoplasms
Mechanical strain attenuates cytokine-induced ADAMTS9 expression via transient receptor potential vanilloid type 1.
Neoplasms
Oncostatin M in combination with tumour necrosis factor {alpha} induces a chondrocyte membrane associated aggrecanase that is distinct from ADAMTS aggrecanase-1 or -2.
Neoplasms
Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer.
Neoplasms
Promotion of Tumor Growth by ADAMTS4 in Colorectal Cancer: Focused on Macrophages.
Neoplasms
Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.
Neoplasms
Reorganization of metastamiRs in the evolution of metastatic aggressive neuroblastoma cells.
Neoplasms
Semaphorin 4D contributes to rheumatoid arthritis by inducing inflammatory cytokine production: Pathogenic and therapeutic implications.
Neoplasms
The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental tumor metastatic potential.
Neoplasms
Time-Dependent Effects of Arthroscopic Conditions on Human Articular Cartilage: An In Vivo Study.
Neoplasms
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
Neoplasms
Upregulation of tumor necrosis factor ? and ADAMTS-5, but not ADAMTS-4, in human intervertebral cartilage endplate with modic changes.
Neurodegenerative Diseases
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Neuroinflammatory Diseases
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Obesity
Expression of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development.
Obesity
Leptin induces ADAMTS-4, ADAMTS-5, and ADAMTS-9 genes expression by mitogen-activated protein kinases and NF-?B signaling pathways in human chondrocytes.
Oligodendroglioma
Microvesicles shed by oligodendroglioma cells and rheumatoid synovial fibroblasts contain aggrecanase activity.
Osteoarthritis
ADAMTS4 (aggrecanase-1) interaction with the C-terminal domain of fibronectin inhibits proteolysis of aggrecan.
Osteoarthritis
ADAMTS4 and ADAMTS5 may be considered as new molecular therapeutic targets for cartilage damages with Kashin-Beck Disease.
Osteoarthritis
Autocatalytic cleavage of ADAMTS-4 (Aggrecanase-1) reveals multiple glycosaminoglycan-binding sites.
Osteoarthritis
Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes.
Osteoarthritis
Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs.
Osteoarthritis
Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
Osteoarthritis
Cirsium japonicum var. maackii and apigenin block Hif-2?-induced osteoarthritic cartilage destruction.
Osteoarthritis
Computational Insights into ADAMTS4, ADAMTS5 and MMP13 Inhibitor Selectivity.
Osteoarthritis
Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.
Osteoarthritis
Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis.
Osteoarthritis
Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments.
Osteoarthritis
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2).
Osteoarthritis
Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors.
Osteoarthritis
Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT).
Osteoarthritis
Double-knockout of ADAMTS-4 and ADAMTS-5 in mice results in physiologically normal animals and prevents the progression of osteoarthritis.
Osteoarthritis
Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation.
Osteoarthritis
Healthy and Osteoarthritic Synovial Fibroblasts Produce a Disintegrin and Metalloproteinase with Thrombospondin Motifs 4, 5, 7, and 12: Induction by IL-1? and Fibronectin and Contribution to Cartilage Damage.
Osteoarthritis
Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
Osteoarthritis
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
Osteoarthritis
Identification of Potent Virtual Leads Specific to S1' Loop of ADAMTS4: Pharmacophore Modeling, 3D-QSAR, Molecular Docking and Dynamic Studies.
Osteoarthritis
IL-1?-induced miR-34a up-regulation inhibits Cyr61 to modulate osteoarthritis chondrocyte proliferation through ADAMTS-4.
Osteoarthritis
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Osteoarthritis
Interrelationship of Osteopontin, MMP-9 and ADAMTS4 in Patients With Osteoarthritis Undergoing Total Joint Arthroplasty.
Osteoarthritis
Matrilin-4 is processed by ADAMTS-5 in late Golgi vesicles present in growth plate chondrocytes of defined differentiation state.
Osteoarthritis
Matrix metalloproteinase-1, -3, -13 and aggrecanase-1 and -2 are differentially expressed in experimental osteoarthritis.
Osteoarthritis
MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes.
Osteoarthritis
MicroRNA-92a-3p Regulates Aggrecanase-1 and Aggrecanase-2 Expression in Chondrogenesis and IL-1?-Induced Catabolism in Human Articular Chondrocytes.
Osteoarthritis
Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy.
Osteoarthritis
Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.
Osteoarthritis
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate.
Osteoarthritis
Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5.
Osteoarthritis
Structural modeling of osteoarthritis ADAMTS4 complex with its cognate inhibitory protein TIMP3 and rational derivation of cyclic peptide inhibitors from the complex interface to target ADAMTS4.
Osteoarthritis
Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis.
Osteoarthritis
Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
Osteoarthritis
The development and characterization of a competitive ELISA for measuring active ADAMTS-4 in a bovine cartilage ex vivo model.
Osteoarthritis
The Effect of Mesenchymal Stem Cell Wharton's Jelly on ADAMTS-4 and iNOS Levels in Osteoarthritis Rat Model.
Osteoarthritis
The effect of protease inhibitors on the induction of osteoarthritis-related biomarkers in bovine full-depth cartilage explants.
Osteoarthritis
The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases.
Osteoarthritis
The regulation of the ADAMTS4 and ADAMTS5 aggrecanases in osteoarthritis: a review.
Osteoarthritis
The role of increased synovial fluid A disintegrin and metalloproteinase with thrombospondin motifs4 and serglycin levels in osteoarthritis.
Osteoarthritis
TIMP-3 inhibition of ADAMTS-4 (Aggrecanase-1) is modulated by interactions between aggrecan and the C-terminal domain of ADAMTS-4.
Osteoarthritis
TNF-? increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis.
Osteoarthritis
Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification.
Osteoarthritis
Tumor necrosis factor-? induces ADAMTS-4 expression in human osteoarthritis chondrocytes.
Osteoarthritis
[Effect of chondrogenesis related miR-4287 on expression of aggrecanase-1 in human chondrocytes].
Osteoarthritis, Knee
Effect of osteopontin on the mRNA expression of ADAMTS4 and ADAMTS5 in chondrocytes from patients with knee osteoarthritis.
Osteoarthritis, Knee
Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages.
Osteoarthritis, Knee
Polymorphisms in ADAMTS4 and ADAMTS5 are not linked to susceptibility to knee osteoarthritis in the Turkish population.
Osteoarthritis, Knee
The utility of synovial fluid levels of ADAMTS9 and ADAMTS4 in predicting treatment responses to intraarticular steroid injections in patients with knee osteoarthritis
Osteoarthritis, Knee
[EXPERIMENTAL STUDY ON LENTIVIRUS-MEDIATED MULTI-GENES CO-TRANSFECTION IN BONE MARROW MESENCHYMAL STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS IN CYNOMOLGUS MONKEY].
Osteosarcoma
ADAMTS-1 increases the three-dimensional growth of osteoblasts through type I collagen processing.
Osteosarcoma
ADAMTS-1: A cellular disintegrin and metalloprotease with thrombospondin motifs is a target for parathyroid hormone in bone.
Osteosarcoma
The role of significantly deregulated MicroRNAs in osteosarcoma based on bioinformatic analysis.
Ovarian Neoplasms
Metalloprotease ADAMTS-1 decreases cell migration and invasion modulating the spatiotemporal dynamics of Cdc42 activity.
Ovarian Neoplasms
Prognostic Value of ADAMTS Proteases and Their Substrates in Epithelial Ovarian Cancer.
Periapical Granuloma
Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst.
Periodontal Diseases
A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis.
Periodontal Diseases
Expression Levels of A disintegrin-like metalloproteinase with thrombospondin motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in inflamed and healthy gingival tissues.
Periodontitis
A disintegrin-like And metalloproteinase with thrombospondin-1 (ADAMTS-1) levels in gingival crevicular fluid correlate with vascular endothelial growth factor-A, hypoxia-inducible factor-1?, and clinical parameters in patients with advanced periodontitis.
Periodontitis
Expression Levels of A disintegrin-like metalloproteinase with thrombospondin motifs-4 and -5 (ADAMTS-4 and ADAMTS-5) in inflamed and healthy gingival tissues.
Pick Disease of the Brain
Metalloproteinase ADAMTS-1 but not ADAMTS-5 is manifold overexpressed in neurodegenerative disorders as Down syndrome, Alzheimer's and Pick's disease.
Polycystic Ovary Syndrome
Abnormal expressions of ADAMTS-1, ADAMTS-9 and progesterone receptors are associated with lower oocyte maturation in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Follicular ADAMTS-1 and aggrecan levels in polycystic ovary syndrome.
Polycystic Ovary Syndrome
The role of serum ADAMTS-1 and aggrecan on polycystic ovary syndrome in adolescents and younger-aged females.
Polymicrogyria
Epileptic and developmental disorders of the speech cortex: ligand/receptor interaction of wild-type and mutant SRPX2 with the plasminogen activator receptor uPAR.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Identification of genetic variants associated with skeletal muscle function deficit in childhood acute lymphoblastic leukemia survivors.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis.
Premature Birth
Associations between second-trimester amniotic fluid levels of ADAMTS4, ADAMTS5, IL-6, and TNF-? and spontaneous preterm delivery in singleton pregnancies.
Prostatic Neoplasms
The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican.
Radicular Cyst
Immunohistochemical analysis of ADAMTS-1, versican and pEGFR expressions in periapical granuloma and radicular cyst.
Renal Insufficiency
Increased expression of HIF-1alpha, VEGF-A and its receptors, MMP-2, TIMP-1, and ADAMTS-1 at the venous stenosis of arteriovenous fistula in a mouse model with renal insufficiency.
Spinal Cord Injuries
ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis.
Spinal Cord Injuries
ADAMTS4 and ADAMTS5 knockout mice are protected from versican but not aggrecan or brevican proteolysis during spinal cord injury.
Spinal Cord Injuries
Anti-inflammatory effects of ADAMTS-4 in a mouse model of ischemic stroke.
Spinal Cord Injuries
Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
Spinal Cord Injuries
The endogenous proteoglycan-degrading enzyme ADAMTS-4 promotes functional recovery after spinal cord injury.
Spinal Cord Injuries
tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury.
Squamous Cell Carcinoma of Head and Neck
Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma.
Stroke
ADAMTS-1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes.
Synovitis
The cytokine expression in synovial membrane and the relationship with pain and pathological findings at hip arthroscopy.
Synovitis
Transcriptional Profiling of Synovium in a Porcine Model of Early Post-traumatic Osteoarthritis.
Tendinopathy
Promoter methylation status of the TIMP2 and ADAMTS4 genes and patellar tendinopathy.
Tendinopathy
The regulation of aggrecanase ADAMTS-4 expression in human Achilles tendon and tendon-derived cells.
Thrombosis
Pro-atherogenic proteoglycanase ADAMTS-1 is down-regulated by lauric acid through PI3K and JNK signaling pathways in THP-1 derived macrophages.
Tuberculosis
Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis.
Tuberculosis, Spinal
Correlation analysis of ADAMTS-4, VCAM-1, and TAK1 expression in cartilage tissue from spine tuberculosis.
Ureteral Obstruction
Expression and significance of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 in an animal model of renal interstitial fibrosis induced by unilateral ureteral obstruction.
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