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Disease on EC 3.4.22.59 - caspase-6

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.
Adenoma, Pleomorphic
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Alzheimer Disease
'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment.
A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.
Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Activation of caspase-6 in aging and mild cognitive impairment.
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease.
Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A.
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Caspase-1 activation of caspase-6 in human apoptotic neurons.
Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.
Caspase-6 activity predicts lower episodic memory ability in aged individuals.
Caspase-6 and neurodegeneration.
Caspase-6 as a novel early target in the treatment of Alzheimer's disease.
Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.
Caspase-6 Latent State Stability Relies on Helical Propensity.
Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits.
Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death.
Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease.
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Differential involvement of caspase-6 in amyloid-?-induced fragmentation of lamin A and B.
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.
Expression and activation of caspase-6 in human fetal and adult tissues.
Identification of Allosteric Inhibitors against Active Caspase-6.
Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.
Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays.
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.
Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration.
Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8.
Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.
Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Tailoring small molecules for an allosteric site on procaspase-6.
Targets of caspase-6 activity in human neurons and Alzheimer disease.
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Arrhythmias, Cardiac
Understanding the molecular role of syndecan-1 in the regulation of caspase-6 during the progression of cardiac arrhythmia.
Blister
Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells.
Brain Injuries
Does Caspase-6 Have a Role in Perinatal Brain Injury?
Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model.
Brain Ischemia
A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest.
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Breast Neoplasms
A P-glycoprotein- and MRP1-independent doxorubicin-resistant variant of the MCF-7 breast cancer cell line with defects in caspase-6, -7, -8, -9 and -10 activation pathways.
Caspase-3 and caspase-6 in ductal breast carcinoma: a descriptive study.
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.
Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells.
Sequence-based discovery of a synthetic peptide inhibitor of caspase 6.
Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.
Carcinogenesis
Fine deletional mapping of chromosome 4q22-35 region in oral cancer.
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Carcinoma
Apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3, 6 and 8 and apoptosis regulating proteins bcl-2, mcl-1 and bax.
Apotosis-related proteins in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix.
Expression of apoptosis-related proteins caspase-6, caspase-9, FLIP and BNIP3 in oesophageal squamous cell carcinomas.
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Genetic model of transformation and neoplastic progression in laryngeal epithelium.
Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Somatic mutation of pro-apoptosis caspase-6 gene is rare in breast and lung carcinomas.
Carcinoma, Hepatocellular
Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent.
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.
Carcinoma, Mucoepidermoid
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Carcinoma, Non-Small-Cell Lung
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Carcinoma, Squamous Cell
Expression of apoptosis-related proteins caspase-6, caspase-9, FLIP and BNIP3 in oesophageal squamous cell carcinomas.
caspase-3 deficiency
Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death.
caspase-6 deficiency
Caspase regulation of genotoxin-induced neural precursor cell death.
Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.
Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7.
Regulation of B-cell entry into the cell cycle.
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Cerebral Infarction
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Colonic Neoplasms
Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells.
Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line.
Expression of Concern: Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53.
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.
Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation.
Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the threshold to resveratrol-evoked apoptosis in colon cancer cells.
Colorectal Neoplasms
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Unbiased proteomic and transcript analyses reveal that stathmin-1 silencing inhibits colorectal cancer metastasis and sensitizes to 5-fluorouracil treatment.
Communicable Diseases
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
COVID-19
[Mechanism of QingfeiPaidu decoction for treatment of COVID-19: analysis based on network pharmacology and molecular docking technology].
Dementia
Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid ?-peptide-independent neuronal degeneration in primary human neuron cultures.
Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.
Diabetes Mellitus, Type 2
Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells.
Epilepsy
Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy.
Fatty Liver
Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition.
Fibrosarcoma
Negatively-regulated necroptosis by autophagy required caspase-6 activation in TNF?-treated murine fibrosarcoma L929 cells.
Gastroenteritis
The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis.
Glioblastoma
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells.
Glioma
FTY720, a novel immunosuppressive agent, induces apoptosis in human glioma cells.
Shuttling SLC2A4RG is regulated by 14-3-3? to modulate cell survival via caspase-3 and caspase-6 in human glioma.
Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.
Heart Arrest
A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest.
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Heart Diseases
Understanding the molecular role of syndecan-1 in the regulation of caspase-6 during the progression of cardiac arrhythmia.
Huntington Disease
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.
A quantitative method for the specific assessment of caspase-6 activity in cell culture.
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.
Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease.
Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.
Compromised IGF signaling causes caspase-6 activation in Huntington disease.
Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays.
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
Palmitoylation of caspase-6 by HIP14 regulates its activation.
Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Hyperalgesia
Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity via netrin-1 in postoperative pain following orthopedic surgery for tibial fracture in mice.
Hypersensitivity
Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity via netrin-1 in postoperative pain following orthopedic surgery for tibial fracture in mice.
Infarction, Middle Cerebral Artery
Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury.
Infections
Adenovirus-Mediated Gene Transfer of FKHRL1 Triple Mutant Efficiently Induces Apoptosis in Melanoma Cells.
Caspase-3 and -7 mediate apoptosis of human Chang's conjunctival cells induced by enterovirus 70.
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres.
Caspase-mediated cleavage of nucleocapsid protein of a protease-independent porcine epidemic diarrhea virus strain.
Examination of the Expression of Immunity Genes and Bacterial Profiles in the Caecum of Growing Chickens Infected with Salmonella Enteritidis and Fed a Phytobiotic.
Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense.
Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.
Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry.
The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells.
Transcriptional regulation of caspases in experimental pneumococcal meningitis.
Influenza, Human
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense.
Ischemic Stroke
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Leukemia
PHOSPHORYLATION-DEPENDENT INTERACTION OF SATB1 AND PIAS1 DIRECTS SUMO-REGULATED CASPASE CLEAVAGE OF SATB1.
Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway.
Liver Cirrhosis
The Metabolic Sensor AMKP Regulates Apoptosis in NASH.
Liver Diseases
Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition.
Lung Neoplasms
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Lymphoma
Apoptosis and expression of caspases 3, 6 and 8 in malignant non-Hodgkin's lymphomas.
Lymphoma, B-Cell
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells.
Lymphoma, Non-Hodgkin
Apoptosis and expression of caspases 3, 6 and 8 in malignant non-Hodgkin's lymphomas.
Mastocytoma
zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells.
Melanoma
Antiapoptotic role of endogenous nitric oxide in human melanoma cells.
Expression of AP-2alpha, c-kit, and cleaved caspase-6 and -3 in naevi and malignant melanomas of the skin. A possible role for caspases in melanoma progression?
Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells.
Melioidosis
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
Memory Disorders
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.
Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Multiple Sclerosis
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Neoplasm Metastasis
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma.
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Neoplasms
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma.
A caspase-6 and anti-human epidermal growth factor receptor-2 (HER2) antibody chimeric molecule suppresses the growth of HER2-overexpressing tumors.
Adiponectin and skeletal muscle: pathophysiological implications in metabolic stress.
Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent.
Caspase-3 and caspase-6 in ductal breast carcinoma: a descriptive study.
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Cells and Cytokines in Milk of Subclinically Infected Bovine Mammary Glands after the Use of Immunomodulatory Composition GLP 810.
Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia.
Differences in the mechanisms of action of BDE-47 and its metabolites on OVCAR-3 and MCF-7 cell apoptosis.
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action.
Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation.
Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.
Expression of AP-2alpha, c-kit, and cleaved caspase-6 and -3 in naevi and malignant melanomas of the skin. A possible role for caspases in melanoma progression?
Expression of caspases-3, -6 and -8 and their relation to apoptosis in non-small cell lung carcinoma.
Fine deletional mapping of chromosome 4q22-35 region in oral cancer.
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis-Related Genes and Cell Cycle Inhibitors.
Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell.
Levetiracetam exhibits protective properties on rat Schwann cells in vitro.
Microarray analysis of gene expression in chondrosarcoma cells treated with bee venom.
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3? pathway.
Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers.
Proteomic characterization of EL4 lymphoma-derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase-6 during tumor cell death in vivo.
Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.
Sequence-based discovery of a synthetic peptide inhibitor of caspase 6.
Shuttling SLC2A4RG is regulated by 14-3-3? to modulate cell survival via caspase-3 and caspase-6 in human glioma.
Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the threshold to resveratrol-evoked apoptosis in colon cancer cells.
Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination.
Synthesis of D-ring annulated pyridosteroids from ?-formyl enamides and their biological evaluations.
The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells.
The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death.
The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats.
Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis.
Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.
[Pro-apoptotic effect on osteosarcoma SOSP-9607 cells by human recombinant caspase-6 fusion protein].
Nervous System Diseases
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Neuralgia
Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.
Neuroblastoma
The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.
Neurodegenerative Diseases
'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment.
A Label-Free LC/MS/MS-Based Enzymatic Activity Assay for the Detection of Genuine Caspase Inhibitors and SAR Development.
A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.
A quantitative method for the specific assessment of caspase-6 activity in cell culture.
Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Caspase-6 and neurodegeneration.
Caspase-6 Latent State Stability Relies on Helical Propensity.
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.
Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.
Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.
Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells.
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.
Palmitoylation of caspase-6 by HIP14 regulates its activation.
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation.
Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Tailoring small molecules for an allosteric site on procaspase-6.
The crystal structure of caspase-6, a selective effector of axonal degeneration.
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Zinc-Mediated Allosteric Inhibition of Caspase-6.
Neuroinflammatory Diseases
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.
Non-alcoholic Fatty Liver Disease
Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition.
Optic Nerve Injuries
Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells.
Osteosarcoma
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma.
[Pro-apoptotic effect on osteosarcoma SOSP-9607 cells by human recombinant caspase-6 fusion protein].
Ovarian Neoplasms
Galectin-9 induces apoptosis in OVCAR-3 ovarian cancer cell through mitochondrial pathway.
Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers.
Parkinson Disease
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Pelger-Huet Anomaly
Role of nuclear lamins in nuclear segmentation of human neutrophils.
Pneumonia
Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M.
Pre-Eclampsia
Effect of hypoxia on expression of placental trophoblast cells SATB1 and ?-catenin and its correlation with the pathogenesis of preeclampsia.
Prostatic Neoplasms
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model.
Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.
Reperfusion Injury
Cloning and expression of rat caspase-6 and its localization in renal ischemia/reperfusion injury.
Seizures
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases.
Stomach Neoplasms
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Prognostic significance of mRNA expression of CASPs in gastric cancer.
Ultrafine particles of Ulmus davidiana var. japonica induce apoptosis of gastric cancer cells via activation of caspase and endoplasmic reticulum stress.
Stroke
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Does Caspase-6 Have a Role in Perinatal Brain Injury?
Palmitoylation of caspase-6 by HIP14 regulates its activation.
Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury.
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Virus Diseases
A novel caspase-6 from sea cucumber Holothuria leucospilota: Molecular characterization, expression analysis and apoptosis detection.
Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection.