Disease on EC 3.4.22.59 - caspase-6
Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Adenoma, Pleomorphic
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Alzheimer Disease
'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment.
Alzheimer Disease
A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.
Alzheimer Disease
Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Alzheimer Disease
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Alzheimer Disease
Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease.
Alzheimer Disease
Alternatively spliced caspase-6B isoform inhibits the activation of caspase-6A.
Alzheimer Disease
APP binds DR6 to trigger axon pruning and neuron death via distinct caspases.
Alzheimer Disease
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Alzheimer Disease
Caspase-6 activation in familial alzheimer disease brains carrying amyloid precursor protein or presenilin i or presenilin II mutations.
Alzheimer Disease
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.
Alzheimer Disease
Caspase-6 activity predicts lower episodic memory ability in aged individuals.
Alzheimer Disease
Caspase-6 as a novel early target in the treatment of Alzheimer's disease.
Alzheimer Disease
Caspase-6 Knockout in the 5xFAD Model of Alzheimer's Disease Reveals Favorable Outcome on Memory and Neurological Hallmarks.
Alzheimer Disease
Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.
Alzheimer Disease
Caspase-6-cleaved Tau fails to induce Tau hyperphosphorylation and aggregation, neurodegeneration, glial inflammation, and cognitive deficits.
Alzheimer Disease
Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death.
Alzheimer Disease
Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease.
Alzheimer Disease
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Alzheimer Disease
Differential involvement of caspase-6 in amyloid-?-induced fragmentation of lamin A and B.
Alzheimer Disease
Early N-terminal changes and caspase-6 cleavage of tau in Alzheimer's disease.
Alzheimer Disease
Identification of Caspase-6-mediated processing of the valosin containing protein (p97) in Alzheimer's disease: a novel link to dysfunction in ubiquitin proteasome system-mediated protein degradation.
Alzheimer Disease
Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.
Alzheimer Disease
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Alzheimer Disease
Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays.
Alzheimer Disease
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Alzheimer Disease
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
Alzheimer Disease
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.
Alzheimer Disease
Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.
Alzheimer Disease
Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration.
Alzheimer Disease
Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
Alzheimer Disease
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Alzheimer Disease
Selective and protracted apoptosis in human primary neurons microinjected with active caspase-3, -6, -7, and -8.
Alzheimer Disease
Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.
Alzheimer Disease
Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Alzheimer Disease
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Alzheimer Disease
Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease.
Amyotrophic Lateral Sclerosis
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Arrhythmias, Cardiac
Understanding the molecular role of syndecan-1 in the regulation of caspase-6 during the progression of cardiac arrhythmia.
Blister
Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells.
Brain Injuries
Recombinant erythropoietin is neuroprotective in a novel mouse oxidative injury model.
Brain Ischemia
A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest.
Brain Ischemia
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Breast Neoplasms
A P-glycoprotein- and MRP1-independent doxorubicin-resistant variant of the MCF-7 breast cancer cell line with defects in caspase-6, -7, -8, -9 and -10 activation pathways.
Breast Neoplasms
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.
Breast Neoplasms
Role of specific apoptotic pathways in the restoration of paclitaxel-induced apoptosis by valspodar in doxorubicin-resistant MCF-7 breast cancer cells.
Breast Neoplasms
Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.
Carcinoma
Apoptosis in gallbladder carcinomas and dysplasias, its relation to the expression of caspases 3, 6 and 8 and apoptosis regulating proteins bcl-2, mcl-1 and bax.
Carcinoma
Apotosis-related proteins in cervical intraepithelial neoplasia and squamous cell carcinoma of the cervix.
Carcinoma
Expression of apoptosis-related proteins caspase-6, caspase-9, FLIP and BNIP3 in oesophageal squamous cell carcinomas.
Carcinoma
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Carcinoma
Genetic model of transformation and neoplastic progression in laryngeal epithelium.
Carcinoma
Somatic mutation of pro-apoptosis caspase-6 gene is rare in breast and lung carcinomas.
Carcinoma, Hepatocellular
Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent.
Carcinoma, Hepatocellular
ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest.
Carcinoma, Mucoepidermoid
Altered expression of apoptosis-regulating miRNAs in salivary gland tumors suggests their involvement in salivary gland tumorigenesis.
Carcinoma, Non-Small-Cell Lung
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
Carcinoma, Non-Small-Cell Lung
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Carcinoma, Squamous Cell
Expression of apoptosis-related proteins caspase-6, caspase-9, FLIP and BNIP3 in oesophageal squamous cell carcinomas.
caspase-3 deficiency
Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death.
caspase-6 deficiency
Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.
caspase-6 deficiency
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
caspase-6 deficiency
Distinct pathways mediate axon degeneration during apoptosis and axon-specific pruning.
caspase-6 deficiency
Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7.
caspase-6 deficiency
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Cerebral Infarction
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Colonic Neoplasms
Aloe Emodin Induces G2/M Cell Cycle Arrest and Apoptosis via Activation of Caspase-6 in Human Colon Cancer Cells.
Colonic Neoplasms
Anti-tumor role of Bacillus subtilis fmbJ-derived fengycin on human colon cancer HT29 cell line.
Colonic Neoplasms
Expression of Concern: Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53.
Colonic Neoplasms
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Colonic Neoplasms
Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.
Colonic Neoplasms
Scutellarin sensitizes drug-evoked colon cancer cell apoptosis through enhanced caspase-6 activation.
Colonic Neoplasms
Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the threshold to resveratrol-evoked apoptosis in colon cancer cells.
Colorectal Neoplasms
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Colorectal Neoplasms
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Colorectal Neoplasms
Unbiased proteomic and transcript analyses reveal that stathmin-1 silencing inhibits colorectal cancer metastasis and sensitizes to 5-fluorouracil treatment.
Communicable Diseases
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
COVID-19
[Mechanism of QingfeiPaidu decoction for treatment of COVID-19: analysis based on network pharmacology and molecular docking technology].
Dementia
Familial amyloid precursor protein mutants cause caspase-6-dependent but amyloid ?-peptide-independent neuronal degeneration in primary human neuron cultures.
Dementia
Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.
Diabetes Mellitus, Type 2
Glucotoxic and diabetic conditions induce caspase 6-mediated degradation of nuclear lamin A in human islets, rodent islets and INS-1 832/13 cells.
Fatty Liver
Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition.
Fibrosarcoma
Negatively-regulated necroptosis by autophagy required caspase-6 activation in TNF?-treated murine fibrosarcoma L929 cells.
Gastroenteritis
The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis.
Glioblastoma
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
Glioblastoma
Major Contribution of Caspase-9 to Honokiol-Induced Apoptotic Insults to Human Drug-Resistant Glioblastoma Cells.
Glioma
Shuttling SLC2A4RG is regulated by 14-3-3? to modulate cell survival via caspase-3 and caspase-6 in human glioma.
Glioma
Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter.
Heart Arrest
A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest.
Heart Arrest
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation.
Heart Diseases
Understanding the molecular role of syndecan-1 in the regulation of caspase-6 during the progression of cardiac arrhythmia.
Huntington Disease
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
Huntington Disease
A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.
Huntington Disease
A quantitative method for the specific assessment of caspase-6 activity in cell culture.
Huntington Disease
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.
Huntington Disease
Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Huntington Disease
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Huntington Disease
Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound.
Huntington Disease
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Huntington Disease
Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease.
Huntington Disease
Caspase-6-Resistant Mutant Huntingtin Does not Rescue the Toxic Effects of Caspase-Cleavable Mutant Huntingtin in vivo.
Huntington Disease
Compromised IGF signaling causes caspase-6 activation in Huntington disease.
Huntington Disease
Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Huntington Disease
Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays.
Huntington Disease
Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.
Huntington Disease
Laquinimod decreases Bax expression and reduces caspase-6 activation in neurons.
Huntington Disease
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
Huntington Disease
Partial rescue of some features of Huntington Disease in the genetic absence of caspase-6 in YAC128 mice.
Huntington Disease
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Huntington Disease
Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.
Huntington Disease
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Huntington Disease
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative.
Hyperalgesia
Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
Hyperalgesia
Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity via netrin-1 in postoperative pain following orthopedic surgery for tibial fracture in mice.
Hypersensitivity
Spinal caspase-6 contributes to remifentanil-induced hyperalgesia via regulating CCL21/CXCR3 pathway in rats.
Hypersensitivity
Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity via netrin-1 in postoperative pain following orthopedic surgery for tibial fracture in mice.
Infarction, Middle Cerebral Artery
Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury.
Infections
Adenovirus-Mediated Gene Transfer of FKHRL1 Triple Mutant Efficiently Induces Apoptosis in Melanoma Cells.
Infections
Caspase-3 and -7 mediate apoptosis of human Chang's conjunctival cells induced by enterovirus 70.
Infections
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Infections
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
Infections
Caspase-Mediated Cleavage of Human Cortactin during Influenza A Virus Infection Occurs in Its Actin-Binding Domains and Is Associated with Released Virus Titres.
Infections
Caspase-mediated cleavage of nucleocapsid protein of a protease-independent porcine epidemic diarrhea virus strain.
Infections
Examination of the Expression of Immunity Genes and Bacterial Profiles in the Caecum of Growing Chickens Infected with Salmonella Enteritidis and Fed a Phytobiotic.
Infections
Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense.
Infections
Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats.
Infections
Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry.
Infections
The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells.
Influenza, Human
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Influenza, Human
Newly Identified Function of Caspase-6 in ZBP1-mediated Innate Immune Responses, NLRP3 Inflammasome Activation, PANoptosis, and Host Defense.
Ischemic Stroke
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Leukemia
PHOSPHORYLATION-DEPENDENT INTERACTION OF SATB1 AND PIAS1 DIRECTS SUMO-REGULATED CASPASE CLEAVAGE OF SATB1.
Leukemia
Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway.
Liver Diseases
Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition.
Lung Neoplasms
?-Hydroxyundec-9-enoic acid induces apoptosis through ROS-mediated endoplasmic reticulum stress in non-small cell lung cancer cells.
Lung Neoplasms
Prognostic assessment of apoptotic gene polymorphisms in non-small cell lung cancer in Chinese.
Lymphoma
Apoptosis and expression of caspases 3, 6 and 8 in malignant non-Hodgkin's lymphomas.
Lymphoma, B-Cell
Lamin A/C cleavage by caspase-6 activation is crucial for apoptotic induction by photodynamic therapy with hexaminolevulinate in human B-cell lymphoma cells.
Lymphoma, Non-Hodgkin
Apoptosis and expression of caspases 3, 6 and 8 in malignant non-Hodgkin's lymphomas.
Mastocytoma
zVAD-fmk, unlike BocD-fmk, does not inhibit caspase-6 acting on 14-3-3/Bad pathway in apoptosis of p815 mastocytoma cells.
Melanoma
Expression of AP-2alpha, c-kit, and cleaved caspase-6 and -3 in naevi and malignant melanomas of the skin. A possible role for caspases in melanoma progression?
Melanoma
Mechanism of cell death induced by spermine and amine oxidase in mouse melanoma cells.
Melioidosis
Caspase-6 mediates resistance against Burkholderia pseudomallei infection and influences the expression of detrimental cytokines.
Memory Disorders
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Memory Disorders
Caspase-6 activity in the CA1 region of the hippocampus induces age-dependent memory impairment.
Memory Disorders
Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Multiple Sclerosis
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Neoplasm Metastasis
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma.
Neoplasm Metastasis
Inflammation-induced tumorigenesis in mouse colon is caspase-6 independent.
Neoplasms
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma.
Neoplasms
A caspase-6 and anti-human epidermal growth factor receptor-2 (HER2) antibody chimeric molecule suppresses the growth of HER2-overexpressing tumors.
Neoplasms
Adiponectin and skeletal muscle: pathophysiological implications in metabolic stress.
Neoplasms
Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense.
Neoplasms
Cells and Cytokines in Milk of Subclinically Infected Bovine Mammary Glands after the Use of Immunomodulatory Composition GLP 810.
Neoplasms
Cleavage of caspases-1, -3, -6, -8 and -9 substrates by proteases in skeletal muscles from mice undergoing cancer cachexia.
Neoplasms
Differences in the mechanisms of action of BDE-47 and its metabolites on OVCAR-3 and MCF-7 cell apoptosis.
Neoplasms
DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.
Neoplasms
Effects of chlorella on activities of protein tyrosine phosphatases, matrix metalloproteinases, caspases, cytokine release, B and T cell proliferations, and phorbol ester receptor binding.
Neoplasms
Effects of intrathecal and intracerebroventricular microinjection of kaempferol on pain: possible mechanisms of action.
Neoplasms
Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation.
Neoplasms
Expression of AP-2alpha, c-kit, and cleaved caspase-6 and -3 in naevi and malignant melanomas of the skin. A possible role for caspases in melanoma progression?
Neoplasms
Expression of caspases-3, -6 and -8 and their relation to apoptosis in non-small cell lung carcinoma.
Neoplasms
Identification of Caspase-6 as a New Regulator of Alternatively Activated Macrophages.
Neoplasms
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas.
Neoplasms
Ketoconazole Treatment Decreases the Viability of Immortalized Pituitary Cell Lines Associated with an Increased Expression of Apoptosis-Related Genes and Cell Cycle Inhibitors.
Neoplasms
Landfill soil leachates from Nigeria and India induced DNA damage and alterations in genes associated with apoptosis in Jurkat cell.
Neoplasms
Microarray analysis of gene expression in chondrosarcoma cells treated with bee venom.
Neoplasms
Neuroprotective potential of ketamine prevents developing brain structure impairment and alteration of neurocognitive function induced via isoflurane through the PI3K/AKT/GSK-3? pathway.
Neoplasms
Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers.
Neoplasms
Proteomic characterization of EL4 lymphoma-derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase-6 during tumor cell death in vivo.
Neoplasms
Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.
Neoplasms
Shuttling SLC2A4RG is regulated by 14-3-3? to modulate cell survival via caspase-3 and caspase-6 in human glioma.
Neoplasms
Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the threshold to resveratrol-evoked apoptosis in colon cancer cells.
Neoplasms
Suppression of mammary gland carcinogenesis by post-initiation treatment of rats with tamoxifen or indole-3-carbinol or their combination.
Neoplasms
Synthesis of D-ring annulated pyridosteroids from ?-formyl enamides and their biological evaluations.
Neoplasms
The effect of direct translocation across endosomes on the cytotoxicity of the recombinant protein e23sFv-Fdt-casp6 to HER2 positive gastric cancer cells.
Neoplasms
The essential role of the mitochondria-dependent death-signaling cascade in chemotherapy-induced potentiation of Apo2L/TRAIL cytotoxicity in cultured thoracic cancer cells: amplified caspase 8 is indispensable for combination-mediated massive cell death.
Neoplasms
The inducing of caspase and Bcl-2 pathway with royal jelly decreases the muscle tissue damage exposed with fluoride in rats.
Neoplasms
Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells.
Neoplasms
[Pro-apoptotic effect on osteosarcoma SOSP-9607 cells by human recombinant caspase-6 fusion protein].
Nervous System Diseases
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Neuralgia
Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain.
Neuroblastoma
The antimicrobial peptide, lactoferricin B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo.
Neurodegenerative Diseases
'Polymorphism-aided' Selective Targeting and Inhibition of Caspase-6 by a Novel Allosteric Inhibitor Towards Efficient Alzheimer's Disease Treatment.
Neurodegenerative Diseases
A Label-Free LC/MS/MS-Based Enzymatic Activity Assay for the Detection of Genuine Caspase Inhibitors and SAR Development.
Neurodegenerative Diseases
A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.
Neurodegenerative Diseases
A quantitative method for the specific assessment of caspase-6 activity in cell culture.
Neurodegenerative Diseases
Activation and regulation of caspase-6 and its role in neurodegenerative diseases.
Neurodegenerative Diseases
Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.
Neurodegenerative Diseases
Caspase inhibitors: a review of recently patented compounds (2013-2015).
Neurodegenerative Diseases
Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
Neurodegenerative Diseases
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding.
Neurodegenerative Diseases
Constitutive ablation of caspase-6 reduces the inflammatory response and behavioural changes caused by peripheral pro-inflammatory stimuli.
Neurodegenerative Diseases
Differential susceptibility of striatal, hippocampal and cortical neurons to Caspase-6.
Neurodegenerative Diseases
Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases.
Neurodegenerative Diseases
Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells.
Neurodegenerative Diseases
Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.
Neurodegenerative Diseases
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions.
Neurodegenerative Diseases
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice.
Neurodegenerative Diseases
Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation.
Neurodegenerative Diseases
Substrate-induced conformational changes occur in all cleaved forms of caspase-6.
Neurodegenerative Diseases
Tailoring small molecules for an allosteric site on procaspase-6.
Neurodegenerative Diseases
The crystal structure of caspase-6, a selective effector of axonal degeneration.
Neurodegenerative Diseases
The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Neuroinflammatory Diseases
Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
Neuroinflammatory Diseases
Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation.
Non-alcoholic Fatty Liver Disease
Salsalate reverses metabolic disorders in a mouse model of non-alcoholic fatty liver disease through AMPK activation and caspase-6 activity inhibition.
Optic Nerve Injuries
Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells.
Osteosarcoma
A caspase-6 and anti-HER2 antibody chimeric tumor-targeted proapoptotic molecule decreased metastasis of human osteosarcoma.
Osteosarcoma
[Pro-apoptotic effect on osteosarcoma SOSP-9607 cells by human recombinant caspase-6 fusion protein].
Ovarian Neoplasms
Galectin-9 induces apoptosis in OVCAR-3 ovarian cancer cell through mitochondrial pathway.
Ovarian Neoplasms
Overexpression and cytoplasmic localization of caspase-6 is associated with lamin A degradation in set of ovarian cancers.
Parkinson Disease
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein.
Pneumonia
Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M.
Pre-Eclampsia
Effect of hypoxia on expression of placental trophoblast cells SATB1 and ?-catenin and its correlation with the pathogenesis of preeclampsia.
Prostatic Neoplasms
A novel dietary triterpene Lupeol induces fas-mediated apoptotic death of androgen-sensitive prostate cancer cells and inhibits tumor growth in a xenograft model.
Prostatic Neoplasms
Expression analysis of caspase-6, caspase-9 and BNIP3 in prostate cancer.
Reperfusion Injury
Cloning and expression of rat caspase-6 and its localization in renal ischemia/reperfusion injury.
Seizures
Expression and differential processing of caspases 6 and 7 in relation to specific epileptiform EEG patterns following limbic seizures.
Stomach Neoplasms
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Stomach Neoplasms
Ultrafine particles of Ulmus davidiana var. japonica induce apoptosis of gastric cancer cells via activation of caspase and endoplasmic reticulum stress.
Stroke
Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity.
Stroke
Propofol Attenuates Inflammatory Damage via Inhibiting NLRP1-Casp1-Casp6 Signaling in Ischemic Brain Injury.
Stroke
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke.
Virus Diseases
A novel caspase-6 from sea cucumber Holothuria leucospilota: Molecular characterization, expression analysis and apoptosis detection.
Virus Diseases
Flavivirus activates phosphatidylinositol 3-kinase signaling to block caspase-dependent apoptotic cell death at the early stage of virus infection.
html completed