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Information on EC 3.4.22.54 - calpain-3 and Organism(s) Sus scrofa and UniProt Accession P43368

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.54 calpain-3
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This record set is specific for:
Sus scrofa
UNIPROT: P43368 not found.
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Word Map
The taxonomic range for the selected organisms is: Sus scrofa
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
broad endopeptidase specificity
broad endopeptidase activity
Synonyms
capn3, calpain 3, calpain-3, ncl-1, calpain3, muscle calpain, skeletal muscle-specific calpain, muscle-specific calpain, calpain 3 (p94), calpain p94, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
calcium-activated neutral proteinase 3
-
-
-
-
calpain 3
-
-
calpain L3
-
-
-
-
calpain p94
-
-
-
-
CANP 3
-
-
-
-
Cn94
-
-
-
-
muscle-specific calcium-activated neutral protease 3
-
-
-
-
nCL-1
-
-
-
-
p94
-
-
-
-
p94-calpain
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
657407-83-5
-
78990-62-2
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
titin + H2O
?
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
titin + H2O
?
show the reaction diagram
-
-
-
-
?
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
regulated by Ca2+, contains 2 EF-hand calcium-binding domains. Activated by micromolar concentrations of calcium
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
calpastatin
-
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CAN3_PIG
821
0
94551
Swiss-Prot
Mitochondrion (Reliability: 5)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
skeletal muscle enzyme
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Bos taurus (P51186), Homo sapiens (P20807), Mus musculus (Q64691), Sus scrofa (P43368)
Manually annotated by BRENDA team
Briley G.P.; Riggs P.K.; Womack, J.E.; Hancock, D.L.; Bidwell, C.A.
Chromosomal localization of the porcine skeletal muscle calpain gene
Mamm. Genome
7
226-228
1996
Sus scrofa (P43368), Sus scrofa
Manually annotated by BRENDA team
Richard, I.; Brenguier, L.; Dincer P.; et al.
Multiple independent molecular etiology for limb-girdle muscular dystrophy type 2A patients from various geographical origins
Am. J. Hum. Genet.
60
1128-1138
1997
Homo sapiens (P20807), Homo sapiens, Sus scrofa (P43368)
Manually annotated by BRENDA team
Yang, X.; Chen, J.; Xu, Q.; Zhao, R.
Muscle type-specific responses of myoD and calpain 3 expression to recombinant porcine growth hormone in the pig
Animal
1
989-996
2007
Sus scrofa
Manually annotated by BRENDA team
Mora, L.; Sentandreu, M.A.; Koistinen, K.M.; Fraser, P.D.; Toldra, F.; Bramley, P.M.
Naturally generated small peptides derived from myofibrillar proteins in Serrano dry-cured ham
J. Agric. Food Chem.
57
3228-3234
2009
Sus scrofa
Manually annotated by BRENDA team