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Disease on EC 3.4.22.37 - gingipain R

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Alveolar Bone Loss
Arg-gingipain A DNA vaccine prevents alveolar bone loss in mice.
HGP44 induces protection against Porphyromonas gingivalis-induced alveolar bone loss in mice.
The role of gingipains in the pathogenesis of periodontal disease.
Alzheimer Disease
Alzheimer disease and the periodontal patient: New insights, connections, and therapies.
Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains.
Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons.
Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens.
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
The Post-amyloid Era in Alzheimer's Disease: Trust Your Gut Feeling.
Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations.
Arthritis
Targeting a cysteine protease from a pathobiont alleviates experimental arthritis.
Arthritis, Rheumatoid
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology.
Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis.
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Atherosclerosis
Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure.
Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis.
Bacteremia
Expression of TNF, IL1B, and  iNOS2 in the neural cell after induced by Porphyromonas gingivalis with and without coating antibody anti -Porphyromonas gingivalis.
Cardiovascular Diseases
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Cholera
Effectiveness of the B subunit of cholera toxin in potentiating immune responses to the recombinant hemagglutinin/adhesin domain of the gingipain Kgp from Porphyromonas gingivalis.
Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid A.
Chronic Periodontitis
Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non-surgical therapy in periodontitis patients: A randomized controlled clinical trial.
Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis.
In Porphyromonas gingivalis VimF is involved in gingipain maturation through the transfer of galactose.
Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases.
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure.
Sera from mice immunized with DNA encoding Porphyromonas gingivalis catalytic or adhesin part of HRgpA inhibit degradation of human fibronectin by HRgpA.
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
The role of gingipains in the pathogenesis of periodontal disease.
Colorectal Neoplasms
Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway.
Fetal Resorption
Anticardiolipin in Porphyromonas gingivalis Antisera Causes Fetal Loss in Mice.
Gingivitis
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.
Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin.
[Clinical association of gingipain K-caspase like subdomain expression of Porphyromonas gingivalis with puberty gingivitis]
Heart Rupture
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture.
Infections
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice.
Antibody responses of periodontitis patients to gingipains of Porphyromonas gingivalis.
Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model.
Benzamidine derivatives inhibit the virulence of Porphyromonas gingivalis.
Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons.
Gingipain of Porphyromonas gingivalis manipulates M1 macrophage polarization through C5a pathway.
HGP44 induces protection against Porphyromonas gingivalis-induced alveolar bone loss in mice.
Immunization by Arg-gingipain A DNA vaccine protects mice against an invasive Porphyromonas gingivalis infection through regulation of interferon-gamma production.
Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion.
Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae.
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.
Oral bacteria and leaky endothelial junctions in remote extraoral sites.
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.
Porphyromonas gingivalis and Alzheimer disease: Recent findings and potential therapies.
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study.
Sphingolipid Containing Outer Membrane Vesicles Serve as a Delivery Vehicle to Limit Macrophage Immune Response to Porphyromonas gingivalis.
The Effects of Oral Rehmannia glutinosa Polysaccharide Administration on Immune Responses, Antioxidant Activity and Resistance Against Aeromonas hydrophila in the Common Carp, Cyprinus carpio L.
Lymphoma
Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.
Neoplasms
Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis.
Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells.
Neurodegenerative Diseases
Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations.
Neuroinflammatory Diseases
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Obstetric Labor, Premature
Periodontal disease and spontaneous preterm birth: a case control study.
Peri-Implantitis
[Experimental research on Arginine-gingipain A gene vaccine from Porphyromonas gingivalis that prevents peri-implantitis in Beagle dogs].
Periodontal Diseases
Activation of calcium signaling in human gingival fibroblasts by recombinant Porphyromonas gingivalis RgpB protein.
Alzheimer disease and the periodontal patient: New insights, connections, and therapies.
Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis.
Arg-gingipain is responsible for the degradation of cell adhesion molecules of human gingival fibroblasts and their death induced by Porphyromonas gingivalis.
Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion.
Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease.
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis.
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.
Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice.
Involvement of arginine-specific cysteine proteinase (Arg-gingipain) in fimbriation of Porphyromonas gingivalis.
Isolation and characterization of a novel and potent inhibitor of Arg-gingipain from Streptomyces sp. strain FA-70.
PorM, a core component of bacterial type IX secretion system, forms a dimer with a unique kinked-rod shape.
Porphyromonas gingivalis proteinases as virulence determinants in progression of periodontal diseases.
Potential value of a rice protein extract, containing proteinaceous inhibitors against cysteine proteinases from Porphyromonas gingivalis, for managing periodontal diseases.
Purification and characterization of a novel arginine-specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis.
Role of Mechanotransduction in Periodontal Homeostasis and Disease.
Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces.
Structural characterization of argingipain, a novel arginine-specific cysteine proteinase as a major periodontal pathogenic factor from Porphyromonas gingivalis.
Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors.
[Gingipains as the determinants of periodontopathogenicity]
Periodontal Pocket
Comparison of Gingival Crevicular Fluid Sampling Methods in Patients With Severe Chronic Periodontitis.
Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non-surgical therapy in periodontitis patients: A randomized controlled clinical trial.
Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells.
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.
Periodontitis
A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems.
Activation of blood coagulation factor X by arginine-specific cysteine proteinases (gingipain-Rs) from Porphyromonas gingivalis.
Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalis.
Anti-inflammatory Effects of PMX205 in Mouse Macrophage Periodontitis Model.
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology.
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice.
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
Effects by periodontitis on pristane-induced arthritis in rats.
Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis.
Identification and Modification of Porphyromonas gingivalis Cysteine Protease, Gingipain, Ideal for Screening Periodontitis.
Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains.
Modulation of an interleukin-12 and gamma interferon synergistic feedback regulatory cycle of T-cell and monocyte cocultures by Porphyromonas gingivalis lipopolysaccharide in the absence or presence of cysteine proteinases.
Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling.
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.
Periodontal treatment down-regulates protease-activated receptor-2 in human gingival crevicular fluid cells.
Polyphenols from Myrothamnus flabellifolia Welw. inhibit in vitro adhesion of Porphyromonas gingivalis and exert anti-inflammatory cytoprotective effects in KB cells.
Porphyromonas gingivalis and Alzheimer disease: Recent findings and potential therapies.
Porphyromonas gingivalis proteinases in periodontitis, a review.
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study.
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System.
The role of gingipains in the pathogenesis of periodontal disease.
The Type IX Secretion System: Advances in Structure, Function and Organisation.
Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis.
Washing- and Separation-Free Electrochemical Detection of Porphyromonas gingivalis in Saliva for Initial Diagnosis of Periodontitis.
Pneumonia, Aspiration
Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis.
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Thrombosis
Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics.