Disease on EC 3.4.22.37 - gingipain R
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Alveolar Bone Loss
HGP44 induces protection against Porphyromonas gingivalis-induced alveolar bone loss in mice.
Alzheimer Disease
Alzheimer disease and the periodontal patient: New insights, connections, and therapies.
Alzheimer Disease
Alzheimer's Disease-Like Neurodegeneration in Porphyromonas gingivalis Infected Neurons with Persistent Expression of Active Gingipains.
Alzheimer Disease
Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons.
Alzheimer Disease
Parkinson's Disease: A Systemic Inflammatory Disease Accompanied by Bacterial Inflammagens.
Alzheimer Disease
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Alzheimer Disease
Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations.
Arthritis
Targeting a cysteine protease from a pathobiont alleviates experimental arthritis.
Arthritis, Rheumatoid
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology.
Arthritis, Rheumatoid
Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis.
Arthritis, Rheumatoid
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Atherosclerosis
Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure.
Atherosclerosis
Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis.
Bacteremia
Expression of TNF, IL1B, and  iNOS2 in the neural cell after induced by Porphyromonas gingivalis with and without coating antibody anti -Porphyromonas gingivalis.
Cardiovascular Diseases
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Cholera
Effectiveness of the B subunit of cholera toxin in potentiating immune responses to the recombinant hemagglutinin/adhesin domain of the gingipain Kgp from Porphyromonas gingivalis.
Cholera
Role of CD80 and CD86 in host immune responses to the recombinant hemagglutinin domain of Porphyromonas gingivalis gingipain and in the adjuvanticity of cholera toxin B and monophosphoryl lipid A.
Chronic Periodontitis
Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non-surgical therapy in periodontitis patients: A randomized controlled clinical trial.
Chronic Periodontitis
Humoral responses to Porphyromonas gingivalis gingipain adhesin domains in subjects with chronic periodontitis.
Chronic Periodontitis
In Porphyromonas gingivalis VimF is involved in gingipain maturation through the transfer of galactose.
Chronic Periodontitis
Osteoprotegerin protects endothelial cells against apoptotic cell death induced by Porphyromonas gingivalis cysteine proteinases.
Chronic Periodontitis
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Chronic Periodontitis
Selective proteolysis of apolipoprotein B-100 by Arg-gingipain mediates atherosclerosis progression accelerated by bacterial exposure.
Chronic Periodontitis
Sera from mice immunized with DNA encoding Porphyromonas gingivalis catalytic or adhesin part of HRgpA inhibit degradation of human fibronectin by HRgpA.
Chronic Periodontitis
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Colorectal Neoplasms
Intracellular Porphyromonas gingivalis Promotes the Proliferation of Colorectal Cancer Cells via the MAPK/ERK Signaling Pathway.
Fetal Resorption
Anticardiolipin in Porphyromonas gingivalis Antisera Causes Fetal Loss in Mice.
Gingivitis
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.
Gingivitis
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.
Gingivitis
Suppression of gingival inflammation induced by Porphyromonas gingivalis in rats by leupeptin.
Gingivitis
[Clinical association of gingipain K-caspase like subdomain expression of Porphyromonas gingivalis with puberty gingivitis]
Heart Rupture
Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture.
Infections
A peptide domain on gingipain R which confers immunity against Porphyromonas gingivalis infection in mice.
Infections
Antibody responses of periodontitis patients to gingipains of Porphyromonas gingivalis.
Infections
Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model.
Infections
Characterization of Human Genes Modulated by Porphyromonas gingivalis Highlights the Ribosome, Hypothalamus, and Cholinergic Neurons.
Infections
Gingipain of Porphyromonas gingivalis manipulates M1 macrophage polarization through C5a pathway.
Infections
HGP44 induces protection against Porphyromonas gingivalis-induced alveolar bone loss in mice.
Infections
Immunization by Arg-gingipain A DNA vaccine protects mice against an invasive Porphyromonas gingivalis infection through regulation of interferon-gamma production.
Infections
Inactivation of tumor necrosis factor-alpha by proteinases (gingipains) from the periodontal pathogen, Porphyromonas gingivalis. Implications of immune evasion.
Infections
Invasion of epithelial cells and proteolysis of cellular focal adhesion components by distinct types of Porphyromonas gingivalis fimbriae.
Infections
Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.
Infections
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Infections
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.
Infections
Porphyromonas gingivalis and Alzheimer disease: Recent findings and potential therapies.
Infections
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Infections
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study.
Infections
Sphingolipid Containing Outer Membrane Vesicles Serve as a Delivery Vehicle to Limit Macrophage Immune Response to Porphyromonas gingivalis.
Infections
The Effects of Oral Rehmannia glutinosa Polysaccharide Administration on Immune Responses, Antioxidant Activity and Resistance Against Aeromonas hydrophila in the Common Carp, Cyprinus carpio L.
Lymphoma
Structural Insights into Separase Architecture and Substrate Recognition through Computational Modelling of Caspase-Like and Death Domains.
Neoplasms
Blockade of protease-activated receptors on T cells correlates with altered proteolysis of CD27 by gingipains of Porphyromonas gingivalis.
Neoplasms
Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells.
Neurodegenerative Diseases
Unrevealing the Proteolytic Activity of RgpB Gingipain from Computational Simulations.
Neuroinflammatory Diseases
Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.
Obstetric Labor, Premature
Periodontal disease and spontaneous preterm birth: a case control study.
Peri-Implantitis
[Experimental research on Arginine-gingipain A gene vaccine from Porphyromonas gingivalis that prevents peri-implantitis in Beagle dogs].
Periodontal Diseases
Activation of calcium signaling in human gingival fibroblasts by recombinant Porphyromonas gingivalis RgpB protein.
Periodontal Diseases
Alzheimer disease and the periodontal patient: New insights, connections, and therapies.
Periodontal Diseases
Arg-gingipain acts as a major processing enzyme for various cell surface proteins in Porphyromonas gingivalis.
Periodontal Diseases
Arg-gingipain is responsible for the degradation of cell adhesion molecules of human gingival fibroblasts and their death induced by Porphyromonas gingivalis.
Periodontal Diseases
Arginine-specific protease from Porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion.
Periodontal Diseases
Biochemical and functional properties of lysine-specific cysteine proteinase (Lys-gingipain) as a virulence factor of Porphyromonas gingivalis in periodontal disease.
Periodontal Diseases
Cleavage and activation of proteinase-activated receptor-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis.
Periodontal Diseases
Inhibition of arginine gingipains (RgpB and HRgpA) with benzamidine inhibitors: zinc increases inhibitory potency.
Periodontal Diseases
Inhibition of gingipains prevents Porphyromonas gingivalis-induced preterm birth and fetal death in pregnant mice.
Periodontal Diseases
Involvement of arginine-specific cysteine proteinase (Arg-gingipain) in fimbriation of Porphyromonas gingivalis.
Periodontal Diseases
Isolation and characterization of a novel and potent inhibitor of Arg-gingipain from Streptomyces sp. strain FA-70.
Periodontal Diseases
PorM, a core component of bacterial type IX secretion system, forms a dimer with a unique kinked-rod shape.
Periodontal Diseases
Porphyromonas gingivalis proteinases as virulence determinants in progression of periodontal diseases.
Periodontal Diseases
Potential value of a rice protein extract, containing proteinaceous inhibitors against cysteine proteinases from Porphyromonas gingivalis, for managing periodontal diseases.
Periodontal Diseases
Purification and characterization of a novel arginine-specific cysteine proteinase (argingipain) involved in the pathogenesis of periodontal disease from the culture supernatant of Porphyromonas gingivalis.
Periodontal Diseases
Role of Porphyromonas gingivalis protease activity in colonization of oral surfaces.
Periodontal Diseases
Structural characterization of argingipain, a novel arginine-specific cysteine proteinase as a major periodontal pathogenic factor from Porphyromonas gingivalis.
Periodontal Diseases
Suppression of pathogenicity of Porphyromonas gingivalis by newly developed gingipain inhibitors.
Periodontal Pocket
Comparison of Gingival Crevicular Fluid Sampling Methods in Patients With Severe Chronic Periodontitis.
Periodontal Pocket
Evaluation of lozenges containing egg yolk antibody against Porphyromonas gingivalis gingipains as an adjunct to conventional non-surgical therapy in periodontitis patients: A randomized controlled clinical trial.
Periodontal Pocket
Gingipains from Porphyromonas gingivalis W83 induce cell adhesion molecule cleavage and apoptosis in endothelial cells.
Periodontal Pocket
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Periodontal Pocket
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.
Periodontitis
A functional virulence complex composed of gingipains, adhesins, and lipopolysaccharide shows high affinity to host cells and matrix proteins and escapes recognition by host immune systems.
Periodontitis
Activation of blood coagulation factor X by arginine-specific cysteine proteinases (gingipain-Rs) from Porphyromonas gingivalis.
Periodontitis
Activation of human prothrombin by arginine-specific cysteine proteinases (Gingipains R) from porphyromonas gingivalis.
Periodontitis
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology.
Periodontitis
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice.
Periodontitis
Crystal structure of gingipain R: an Arg-specific bacterial cysteine proteinase with a caspase-like fold.
Periodontitis
Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis.
Periodontitis
Identification and Modification of Porphyromonas gingivalis Cysteine Protease, Gingipain, Ideal for Screening Periodontitis.
Periodontitis
Inflammatory response of uric acid produced by Porphyromonas gingivalis gingipains.
Periodontitis
Modulation of an interleukin-12 and gamma interferon synergistic feedback regulatory cycle of T-cell and monocyte cocultures by Porphyromonas gingivalis lipopolysaccharide in the absence or presence of cysteine proteinases.
Periodontitis
Neuropeptide release from dental pulp cells by RgpB via proteinase-activated receptor-2 signaling.
Periodontitis
PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity.
Periodontitis
Pathogenesis of periodontitis: a major arginine-specific cysteine proteinase from Porphyromonas gingivalis induces vascular permeability enhancement through activation of the kallikrein/kinin pathway.
Periodontitis
Periodontal treatment down-regulates protease-activated receptor-2 in human gingival crevicular fluid cells.
Periodontitis
Polyphenols from Myrothamnus flabellifolia Welw. inhibit in vitro adhesion of Porphyromonas gingivalis and exert anti-inflammatory cytoprotective effects in KB cells.
Periodontitis
Porphyromonas gingivalis and Alzheimer disease: Recent findings and potential therapies.
Periodontitis
Smoking, Porphyromonas gingivalis and the immune response to citrullinated autoantigens before the clinical onset of rheumatoid arthritis in a Southern European nested case-control study.
Periodontitis
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Periodontitis
Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System.
Periodontitis
The Type IX Secretion System: Advances in Structure, Function and Organisation.
Periodontitis
Transcriptional profiling of human smooth muscle cells infected with gingipain and fimbriae mutants of Porphyromonas gingivalis.
Periodontitis
Washing- and Separation-Free Electrochemical Detection of Porphyromonas gingivalis in Saliva for Initial Diagnosis of Periodontitis.
Pneumonia, Aspiration
Gingipains: Critical Factors in the Development of Aspiration Pneumonia Caused by Porphyromonas gingivalis.
Pneumonia, Aspiration
Strategies for the inhibition of gingipains for the potential treatment of periodontitis and associated systemic diseases.
Thrombosis
Gingipain R1 and Lipopolysaccharide From Porphyromonas gingivalis Have Major Effects on Blood Clot Morphology and Mechanics.
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