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Information on EC 3.4.22.15 - cathepsin L
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- 3.4.22.15
- cathepsins
- lysosomal
- proteinases
- cystatins
- papain
- metastasis
- peptidase
- fasciola
- hepatica
-
fluorogenic
-
collagenolytic
- pepstatin
-
trematode
- tmprss2
-
metacercariae
-
stefins
- medicine
- endosomal
-
procathepsin
- kininogens
- endolysins
- pharmacology
-
papain-like
- fluke
-
b-like
- covid-19
- trypanosoma
- mers-cov
- leupeptin
- calpains
-
proregions
-
excysted
- azocasein
- prodomains
- osteoclast
- coronavirus
-
fasciolosis
- collagen
- cruzain
- drug development
-
excretory-secretory
- ace2
- heparanase
- legumain
- endopeptidases
- sars-cov-2
-
elastinolytic
- propeptide
- gigantica
- diagnostics
- proenzyme
-
helminth
- microplus
-
surimi
The enzyme appears in viruses and cellular organisms
Reaction Schemes
similar to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity
Synonyms
cathepsin l, cathepsin l-like, cathepsin-l, human cathepsin l, cpl-1, cat l, cwp84, cathl, major excreted protein, smcl1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
Aldrichina grahami cysteine proteinase
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major excreted protein
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MEP
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PDP
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progesterone-dependent protein
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SMCL1
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CAS REGISTRY NUMBER
COMMENTARY
60616-82-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
(N-[4-(5-benzoyl-1H-benzimidazol-2-yl)phenyl]-2-chlorobenzamide)
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2,6-dimethoxy-4-[4-(4-phenoxyphenyl)-5-phenyl-1H-imidazol-2-yl]phenol
the compound shows significant inhibitory activity against rhodesain, but displays poor antitrypanosomal activity at 0.020 mM
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
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2-(1,3-benzodioxol-5-yl)-5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
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2-(3,4-dimethoxyphenyl)-5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
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2-(4-methoxyphenyl)-4-[8-[2-(4-methoxyphenyl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazole
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2-(4-methoxyphenyl)-5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
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2-(acetylamino)-N-[4-(6-[[2-(acetylamino)benzoyl]amino]-1H-benzimidazol-2-yl)phenyl]benzamide
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2-(furan-2-yl)-4-[8-[2-(furan-2-yl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazole
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4,4'-[methanediylbis(1H-benzimidazole-5,2-diyl)]dianiline
has H-bond and steric interactions with Cys 25 of rhodesain's catalytic triad as well as residues Leu67 and Met68 while its dianiline motifs have steric interactions with Gly64 and Leu160
4-(4-[8-[2-(4-carboxyphenyl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazol-2-yl)benzoic acid
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4-(4-[8-[2-(4-hydroxyphenyl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazol-2-yl)phenol
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4-amino-N-(4-[6-[(4-aminobenzoyl)amino]-1H-benzimidazol-2-yl]phenyl)benzamide
the compound shows significant inhibitory activity against rhodesain, but displays poor antitrypanosomal activity at 0.020 mM
4-[(E)-benzylideneamino]-N-[4-[6-([4-[(E)-benzylideneamino]benzoyl]amino)-1H-benzimidazol-2-yl]phenyl]benzamide
the compound shows significant inhibitory activity against rhodesain, but displays poor antitrypanosomal activity at 0.020 mM
4-[4-(5,5-dioxidodibenzo[b,d]thiophen-2-yl)-5-phenyl-1H-imidazol-2-yl]-2,6-dimethoxyphenol
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4-[5-(4-[[2-(4-aminophenyl)-1H-benzimidazol-6-yl]oxy]phenoxy)-1H-benzimidazol-2-yl]aniline
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4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
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4-[8-(2,4-diphenyl-1H-imidazol-5-yl)dibenzo[b,d]furan-2-yl]-2,5-diphenyl-1H-imidazole)
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5-phenyl-4-[4-(phenylsulfanyl)phenyl]-2-(2,4,5-trimethoxyphenyl)-1H-imidazole
the compound shows significant inhibitory activity against rhodesain, but displays poor antitrypanosomal activity at 0.020 mM
5-phenyl-4-[4-(phenylsulfanyl)phenyl]-2-(3,4,5-trimethoxyphenyl)-1H-imidazole
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bis[2-(4-aminophenyl)-1H-benzimidazol-5-yl]methanone
the compound shows significant inhibitory activity against rhodesain, but displays poor antitrypanosomal activity at 0.020 mM
N-[4-(1H-benzimidazol-2-yl)phenyl]-2,2-diphenylacetamide
the compound shows significant inhibitory activity against rhodesain, but displays poor antitrypanosomal activity at 0.020 mM
N-[4-(5-benzoyl-1H-benzimidazol-2-yl)phenyl]-2-chlorobenzamide
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additional information
screening and identification of inhibitors of Trypanosoma brucei cathepsin L with antitrypanosomal activity, overview. No inhibition by 7 and 13
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Abortion, Spontaneous
[Expression of cathepsins B and L in early gestational decidua and chorionic villi]
Acute Coronary Syndrome
Plasma cathepsin L and its related pro/antiangiogenic factors play useful roles in predicting rich coronary collaterals in patients with coronary heart disease.
Acute Coronary Syndrome
Serum and saliva levels of cathepsin L in patients with acute coronary syndrome.
Acute Coronary Syndrome
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Adenocarcinoma
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Adenocarcinoma
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Adenocarcinoma
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Adenocarcinoma
Prognostic impact of cysteine proteases cathepsin B and cathepsin L in pancreatic adenocarcinoma.
Adenocarcinoma
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Adenocarcinoma of Lung
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Albuminuria
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
Alopecia
The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.
Alzheimer Disease
Abeta-mediated activation of the apoptotic cascade in cultured cortical neurones: a role for cathepsin-L.
Alzheimer Disease
Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease.
Alzheimer Disease
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Alzheimer Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Amyloidosis
Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis.
Amyloidosis
Proteolysis of serum amyloid A and AA amyloid proteins by cysteine proteases: cathepsin B generates AA amyloid proteins and cathepsin L may prevent their formation.
Amyotrophic Lateral Sclerosis
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Aneurysm
Activity of enzymes with different subcellular localization in the blood plasma of patients with aortic aneurysm.
Aneurysm
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Aneurysm
Differential expression of genes in elastase-induced saccular aneurysms with high and low aspect ratios.
Angina, Stable
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Angina, Unstable
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Aortic Aneurysm
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Aortic Aneurysm
Expression levels of cathepsin L and cystatin C in a hyperglycemic environment were associated with aortic aneurysm development in a mouse model.
Aortic Aneurysm, Abdominal
Cathepsin L Activity Is Essential to Elastase Perfusion-Induced Abdominal Aortic Aneurysms in Mice.
Aortic Aneurysm, Abdominal
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
Arteriosclerosis
Effects of intermittent exercise on biomarkers of cardiovascular risk in night shift workers.
Arthritis
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Arthritis
Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis.
Arthritis
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Arthritis
Elevation of cathepsin L levels in the synovial lining of rabbits with antigen-induced arthritis.
Arthritis
Mode of activation of the precursor to cathepsin L: implication for matrix degradation in arthritis.
Arthritis, Experimental
Purification and characterization of collagenolytic property of renal cathepsin L from arthritic rat.
Arthritis, Rheumatoid
Cathepsin S and cathepsin L in serum and synovial fluid in rheumatoid arthritis with and without autoantibodies.
Arthritis, Rheumatoid
Cathepsins B and L in synovial fluids from patients with rheumatoid arthritis and the effect of cathepsin B on the activation of pro-urokinase.
Arthritis, Rheumatoid
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Arthritis, Rheumatoid
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Arthritis, Rheumatoid
Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment.
Arthritis, Rheumatoid
Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.
Arthritis, Rheumatoid
Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis.
Arthritis, Rheumatoid
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Arthritis, Rheumatoid
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Arthritis, Rheumatoid
Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.
Astrocytoma
Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7.
Astrocytoma
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Atherosclerosis
Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice.
Atherosclerosis
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
Atherosclerosis
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis.
Atherosclerosis
Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis.
Atherosclerosis
Modulation of Cathepsin L Expression in the Coronary Arteries of Atherosclerotic Swine.
Atherosclerosis
Overexpression of transferrin receptor and ferritin related to clinical symptoms and destabilization of human carotid plaques.
Atherosclerosis
Peroxisome Proliferator-activated Receptor {gamma} Induces Apoptosis and Inhibits Autophagy of Human Monocyte-derived Macrophages via Induction of Cathepsin L: POTENTIAL ROLE IN ATHEROSCLEROSIS.
Bacteremia
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
Bacterial Infections
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus).
Bacterial Infections
Immunodiagnostic/protective role of Cathepsin L cysteine proteinases secreted by Fasciola species.
Bacterial Infections
Macrobrachium rosenbergii cathepsin L: Molecular characterization and gene expression in response to viral and bacterial infections.
Bone Diseases, Metabolic
Soluble cathepsin-L: a marker of bone resorption and bone density?
Bone Resorption
An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions.
Bone Resorption
Conditioned medium from ras oncogene-transformed NIH 3T3 cells induces bone resorption in vitro.
Bone Resorption
Distinct roles of cathepsin K and cathepsin L in osteoclastic bone resorption.
Bone Resorption
Effects of an inhibitor of cathepsin L on bone resorption in thyroparathyroidectomized and ovariectomized rats.
Bone Resorption
Effects of rat fetuin on stimulation of bone resorption in the presence of parathyroid hormone.
Bone Resorption
Immunohistochemical localization of cathepsins B, D and L in the rat osteoclast.
Bone Resorption
Localization of rat cathepsin K in osteoclasts and resorption pits: inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones.
Bone Resorption
Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.
Bone Resorption
Regulation of collagenolytic cysteine protease synthesis by estrogen in osteoclasts.
Bone Resorption
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Bone Resorption
Study of the functional share of lysosomal cathepsins by the development of specific inhibitors.
Bone Resorption
Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption.
Bone Resorption
The mechanisms and regulation of procathepsin L secretion from osteoclasts in bone resorption.
Brain Injuries, Traumatic
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma.
Brain Injuries, Traumatic
The neuroprotective effect of acute moderate alcohol consumption on caspase-3 mediated neuroapoptosis in traumatic brain injury: the role of lysosomal cathepsin L and nitric oxide.
Brain Ischemia
Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia.
Brain Neoplasms
Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics.
Brain Neoplasms
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Brain Neoplasms
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Breast Neoplasms
An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis.
Breast Neoplasms
Association of Epithelial Mesenchymal Transition with prostate and breast health disparities.
Breast Neoplasms
Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells.
Breast Neoplasms
Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators.
Breast Neoplasms
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Breast Neoplasms
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Breast Neoplasms
CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-?) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Breast Neoplasms
Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report.
Breast Neoplasms
Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patients.
Breast Neoplasms
Correction for Burton et al., "Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor".
Breast Neoplasms
Development of a highly potent, selective, and cell-active inhibitor of cysteine cathepsin L-A hybrid design approach.
Breast Neoplasms
Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells.
Breast Neoplasms
Discovery of a novel and selective cathepsin L inhibitor with anti-metastatic ability in vitro and in vivo against breast cancer cells.
Breast Neoplasms
Effects of Vacuolar H(+)-ATPase Inhibition on Activation of Cathepsin B and Cathepsin L Secreted from MDA-MB231 Breast Cancer Cells.
Breast Neoplasms
Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell lines.
Breast Neoplasms
Identification of low-risk node-negative breast cancer patients by tumor biological factors PAI-1 and cathepsin L.
Breast Neoplasms
Initial evaluation of the antitumour activity of KGP94, a functionalized benzophenone thiosemicarbazone inhibitor of cathepsin L.
Breast Neoplasms
Novel roles of 1?,25(OH)2D3 on DNA repair provide new strategies for breast cancer treatment.
Breast Neoplasms
Prognostic significance of cathepsins B and L in primary human breast cancer.
Breast Neoplasms
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Breast Neoplasms
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration.
Breast Neoplasms
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.
Breast Neoplasms
Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1.
Breast Neoplasms
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
Breast Neoplasms
Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor.
Caliciviridae Infections
Endosomal acidification and cathepsin L activity is required for calicivirus replication.
Carcinogenesis
Cathepsin L interacts with CDK2-AP1 as a potential predictor of prognosis in patients with breast cancer.
Carcinogenesis
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage.
Carcinogenesis
Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.
Carcinogenesis
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
Carcinogenesis
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.
Carcinogenesis
Differential Impact of Cysteine Cathepsins on Genetic Mouse Models of De novo Carcinogenesis: Cathepsin B as Emerging Therapeutic Target.
Carcinogenesis
Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.
Carcinogenesis
Induction of putative tumor-suppressing genes in Rat-1 fibroblasts by oncogenic Raf-1 as evidenced by robot-assisted complex hybridization.
Carcinogenesis
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
Carcinogenesis
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells.
Carcinogenesis
Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.
Carcinogenesis
Wild type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells.
Carcinoma
Activities of serum cathepsin (B, H and L) and metalloproteinase (MMP7-ase) in patients with gastrointestinal and bronchial malignant tumours.
Carcinoma
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Carcinoma
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Carcinoma
Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder.
Carcinoma
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Carcinoma
Concentrations of lysosomal cysteine proteases are decreased in renal cell carcinoma compared with normal kidney.
Carcinoma
Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-?B.
Carcinoma
Cysteine proteases and cysteine protease inhibitors in non-small cell lung cancer.
Carcinoma
Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor???mediated epithelial?mesenchymal transition.
Carcinoma
Electrophoretic analysis of the "cross-class" interaction between novel inhibitory serpin, squamous cell carcinoma antigen-1 and cysteine proteinases.
Carcinoma
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Carcinoma
Expression profiling of supraglottic carcinoma: PTEN and thrombospondin 2 are associated with inhibition of lymphatic metastasis.
Carcinoma
Functional consequences of cathepsin L deficiency in human lung epithelial cells.
Carcinoma
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Carcinoma
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Carcinoma
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Carcinoma
Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma.
Carcinoma
Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma.
Carcinoma
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
Carcinoma
Role of urinary cathepsin B and L in the detection of bladder urothelial cell carcinoma.
Carcinoma
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Carcinoma
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
Carcinoma
The application value of the detection of the level of tissue polypeptide antigen, ovarian cancer antigen X1, cathepsin L and CA125 on the diagnosis of epithelial ovarian cancer.
Carcinoma
[Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells.]
Carcinoma in Situ
Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-?B.
Carcinoma, Basal Cell
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Carcinoma, Hepatocellular
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Carcinoma, Hepatocellular
Increased expression of cathepsin L: a novel independent prognostic marker of worse outcome in hepatocellular carcinoma patients.
Carcinoma, Lewis Lung
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Carcinoma, Non-Small-Cell Lung
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Carcinoma, Non-Small-Cell Lung
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium.
Carcinoma, Non-Small-Cell Lung
Overexpression of Cathepsin L is associated with gefitinib resistance in non-small cell lung cancer.
Carcinoma, Non-Small-Cell Lung
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Carcinoma, Ovarian Epithelial
Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
The application value of the detection of the level of tissue polypeptide antigen, ovarian cancer antigen X1, cathepsin L and CA125 on the diagnosis of epithelial ovarian cancer.
Carcinoma, Ovarian Epithelial
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Carcinoma, Renal Cell
"Disrupted in renal carcinoma 2" (DIRC2) - a novel transporter of the lysosomal membrane - is proteolytically processed by cathepsin L.
Carcinoma, Renal Cell
Concentrations of lysosomal cysteine proteases are decreased in renal cell carcinoma compared with normal kidney.
Carcinoma, Squamous Cell
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Carcinoma, Squamous Cell
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Carcinoma, Squamous Cell
Electrophoretic analysis of the "cross-class" interaction between novel inhibitory serpin, squamous cell carcinoma antigen-1 and cysteine proteinases.
Carcinoma, Squamous Cell
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Carcinoma, Squamous Cell
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Carcinoma, Squamous Cell
Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus.
Carcinoma, Squamous Cell
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
Cardiac Output, Low
Ultrastructural changes in myocardial cells of rats fed a low protein diet.
Cardiomegaly
Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF?/ASK1/JNK pathway.
Cardiomegaly
Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways.
Cardiomegaly
Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling.
Cardiomyopathies
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.
Cardiomyopathies
Microarray Analysis of Polychlorinated Biphenyl Mixture-Induced Changes in Gene Expression among Atlantic Tomcod Populations Displaying Differential Sensitivity to Halogenated Aromatic Hydrocarbons.
Cardiomyopathies
Microarray analysis of polychlorinated biphenyl mixture-induced changes in gene expression among atlantic tomcod populations displaying differential sensitivity to halogenated aromatic hydrocarbons.
Cardiomyopathy, Dilated
Cell type-specific functions of the lysosomal protease cathepsin L in the heart.
Cardiomyopathy, Dilated
Clinical significance of cathepsin L and cathepsin B in dilated cardiomyopathy.
Cardiomyopathy, Dilated
Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.
Cardiomyopathy, Dilated
Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.
Cardiomyopathy, Dilated
[The expression and significance of myocardial cathepsin L in dilated cardiomyopathy]
Cardiovascular Diseases
Caspase-3 activation triggers extracellular cathepsin L release and endorepellin proteolysis.
Cardiovascular Diseases
Cystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children.
Cardiovascular Diseases
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration.
Cardiovascular Diseases
The association between serum cathepsin L and mortality in older adults.
Carotid Artery Injuries
Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.
Carotid Artery Injuries
OS 02-05 MYD88 ON MACROPHAGE TRIGGERS CATHEPSIN L ACTIVATION DRIVEN VASCULAR INTIMAL HYPERPLASIA.
cathepsin l deficiency
Cathepsin K activity-dependent regulation of osteoclast actin ring formation and bone resorption.
cathepsin l deficiency
Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.
cathepsin l deficiency
Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice.
cathepsin l deficiency
Cathepsin L deficiency results in reactive oxygen species (ROS) accumulation and vascular cells activation.
cathepsin l deficiency
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
cathepsin l deficiency
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
cathepsin l deficiency
Epidermal differentiation: the role of proteases and their inhibitors.
cathepsin l deficiency
Functional consequences of cathepsin L deficiency in human lung epithelial cells.
cathepsin l deficiency
Out-of-frame start codons prevent translation of truncated nucleo-cytosolic cathepsin L in vivo.
cathepsin s deficiency
Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice.
Chagas Disease
Characterisation of Trypanosoma cruzi populations by DNA polymorphism of the cruzipain gene detected by single-stranded DNA conformation polymorphism (SSCP) and direct sequencing.
Chagas Disease
Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
Chagas Disease
Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay.
Choroidal Neovascularization
Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization.
Clonorchiasis
Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L-like protease from Clonorchis sinensis.
Clonorchiasis
Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen.
Clostridium Infections
Immunization of hamsters against Clostridium difficile infection using the Cwp84 protease as an antigen.
Coinfection
Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases.
Colorectal Neoplasms
Construction of a plasmid coding for green fluorescent protein tagged cathepsin L and data on expression in colorectal carcinoma cells.
Colorectal Neoplasms
Levels of serum cathepsin L and several glycosidases in patients operated for colorectal cancer.
Colorectal Neoplasms
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer.
Colorectal Neoplasms
Nuclear cathepsin L activity is required for cell cycle progression of colorectal carcinoma cells.
Colorectal Neoplasms
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Colorectal Neoplasms
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
Common Cold
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.
Coronary Artery Disease
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis.
Coronary Artery Disease
Increased Circulating Cathepsin L in Patients with Coronary Artery Disease.
Coronary Disease
Plasma cathepsin L and its related pro/antiangiogenic factors play useful roles in predicting rich coronary collaterals in patients with coronary heart disease.
Coronary Disease
Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease.
Coronary Disease
[Association of cathepsin L with coronary heart disease and its risk factors]
Coronary Stenosis
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
Coronary Stenosis
[Association of cathepsin L with coronary heart disease and its risk factors]
COVID-19
Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development.
COVID-19
Elucidating the drug repurposing spectra of COVID-19 with its analogues SARS and MERS.
COVID-19
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2.
COVID-19
MPI8 is Potent against SARS-CoV-2 by Inhibiting Dually and Selectively the SARS-CoV-2 Main Protease and the Host Cathepsin L*.
COVID-19
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
COVID-19
Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L.
COVID-19
Simultaneous Treatment of COVID-19 With Serine Protease Inhibitor Camostat and/or Cathepsin L Inhibitor?
Cysticercosis
Characterization of a novel cathepsin L-like protease from Taenia solium metacestodes for the immunodiagnosis of porcine cysticercosis.
Cysticercosis
Utility of a protein fraction with cathepsin L-Like activity purified from cysticercus fluid of Taenia solium in the diagnosis of human cysticercosis.
Cysts
Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection.
Cysts
Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini.
Cysts
The highly antigenic 53/25 kDa Taenia solium protein fraction with cathepsin-L like activity is present in the oncosphere/cysticercus and induces non-protective IgG antibodies in pigs.
Dermatitis, Atopic
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Dermatitis, Atopic
Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.
Diabetes Mellitus
High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells.
Diabetes Mellitus
Neutrophil gelatinase-associated lipocalin and Cathepsin L as early predictors of kidney dysfunction in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.
Diabetes Mellitus, Type 1
Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.
Diabetes Mellitus, Type 1
Immunoreactivity of cytotoxic T-lymphocyte antigen 2 alpha in mouse pancreatic islet cells.
Diabetes Mellitus, Type 1
Neutrophil gelatinase-associated lipocalin and Cathepsin L as early predictors of kidney dysfunction in children with type 1 diabetes.
Diabetes Mellitus, Type 1
Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse.
Diabetes Mellitus, Type 2
High glucose reduces cathepsin L activity and impairs invasion of circulating progenitor cells.
Diabetes Mellitus, Type 2
Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.
Diabetes Mellitus, Type 2
Structure-based development of specific inhibitors for individual cathepsins and their medical applications.
Diabetes Mellitus, Type 2
Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study.
Diabetic Nephropathies
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
Diabetic Nephropathies
Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.
Diabetic Retinopathy
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy.
Echinococcosis
Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection.
Echinococcosis
Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes.
Encephalitis, Japanese
Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells.
Encephalomyelitis
Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis.
Encephalomyelitis, Autoimmune, Experimental
Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis.
Endocarditis
Therapeutic effects of bacteriophage Cpl-1 lysin against Streptococcus pneumoniae endocarditis in rats.
Endometrial Neoplasms
Expression of cathepsin L in normal endometrium and endometrial cancer.
Endometrial Neoplasms
Expression of cysteine protease cathepsin L is increased in endometrial cancer and correlates with expression of growth regulatory genes.
Eosinophilia
Host responses during experimental infection with Fasciola gigantica and Fasciola hepatica in Merino sheep II. Development of a predictive index for Fasciola gigantica worm burden.
Epiretinal Membrane
Coexpression of heparanase activity, cathepsin L, tissue factor, tissue factor pathway inhibitor, and MMP-9 in proliferative diabetic retinopathy.
Esophageal Neoplasms
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Fascioliasis
Effectiveness of Fasciola gigantica excretory-secretory and recombinant cathepsin L antigens for rapid diagnosis of human fascioliasis using immunochromatographic devices.
Fascioliasis
Immunization with cathepsin L proteinases CL1 and CL2 secreted by Fasciola hepatica elicit a preferential type 1 response based on IgG2a antibodies in rats.
Fascioliasis
Serodiagnosis of human fascioliasis by a cystatin capture enzyme-linked immunosorbent assay with recombinant Fasciola gigantica cathepsin L antigen.
Fascioliasis
The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease.
Fascioliasis
Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep.
Fatty Liver
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Fibrosarcoma
An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis.
Fibrosarcoma
An examination of the effects of hypoxia, acidosis, and glucose starvation on the expression of metastasis-associated genes in murine tumor cells.
Fibrosarcoma
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells.
Folliculitis
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Frontotemporal Dementia
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Frontotemporal Lobar Degeneration
The lysosomal protein cathepsin L is a progranulin protease.
Gastrointestinal Stromal Tumors
Cathepsin L is highly expressed in gastrointestinal stromal tumors.
Gastrointestinal Stromal Tumors
MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor.
Gingival Hyperplasia
Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts.
Gingival Overgrowth
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
Gingival Overgrowth
Long-term cyclosporin A exposure suppresses cathepsin-B and -L activity in gingival fibroblasts.
Glioblastoma
Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics.
Glioblastoma
Cathepsin L silencing enhances arsenic trioxide mediated in vitro cytotoxicity and apoptosis in glioblastoma U87MG spheroids.
Glioblastoma
Cathepsin L silencing increases As2O3 toxicity in malignantly transformed pilocytic astrocytoma MPA58 cells by activating caspases 3/7.
Glioblastoma
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Glioblastoma
Identification of secreted proteins regulated by cAMP in glioblastoma cells using glycopeptide capture and label-free quantification.
Glioblastoma
Inhibition of cathepsin L lowers the apoptotic threshold of glioblastoma cells by up-regulating p53 and transcription of caspases 3 and 7.
Glioblastoma
Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells.
Glioblastoma
Wild type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells.
Glioma
Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells.
Glioma
Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells.
Glioma
Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3?/CUX1 pathway.
Glioma
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage.
Glioma
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Glioma
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Glioma
Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro.
Glioma
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Glomerulonephritis
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis.
Hemangioendothelioma
Generation and degradation of human endostatin proteins by various proteinases.
Hepatitis A
The unique role of domain 2A of the hepatitis A virus precursor polypeptide P1-2A in viral morphogenesis.
Herpes Simplex
Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells.
Hidradenitis Suppurativa
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Huntington Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Hydatidiform Mole
[Expression of cathepsins B and L in early gestational decidua and chorionic villi]
Hypercalcemia
Conditioned medium from ras oncogene-transformed NIH 3T3 cells induces bone resorption in vitro.
Hypertension
Angiotensin II-Induced vascular remodeling and hypertension involves cathepsin L/V- MEK/ERK mediated mechanism.
Hypertension
Association Between Polymorphism in the Human Cathepsin L (CTSL1) Promoter with Hypertension in the Uygur, Kazak and Han Populations in China.
Hyperthyroidism
Experimental hyperthyroidism in rats increases the expression of the ubiquitin ligases atrogin-1 and MuRF1 and stimulates multiple proteolytic pathways in skeletal muscle.
Hypotension
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
Idiopathic Pulmonary Fibrosis
A novel cathepsin L inhibitor prevents the progression of idiopathic pulmonary fibrosis.
Infarction, Middle Cerebral Artery
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Infections
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Infections
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites.
Infections
Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection.
Infections
Analysis of expressed sequence tags (ESTs) and gene expression changes under different growth conditions for the ciliate Anophryoides haemophila, the causative agent of bumper car disease in the American lobster (Homarus americanus).
Infections
Anaplasma phagocytophilum increases cathepsin L activity, thereby globally influencing neutrophil function.
Infections
Biomphalaria glabrata transcriptome: cDNA microarray profiling identifies resistant- and susceptible-specific gene expression in haemocytes from snail strains exposed to Schistosoma mansoni.
Infections
Can bacteriophage endolysins be nebulised for inhalation delivery against Streptococcus pneumoniae?
Infections
Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells.
Infections
Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection.
Infections
Cathepsin L is an immune-related protein in Pacific abalone (Haliotis discus hannai)--Purification and characterization.
Infections
Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.
Infections
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Infections
Cathepsin L maturation and activity is impaired in macrophages harboring M. avium and M. tuberculosis.
Infections
Cathepsin L of the sea cucumber Apostichopus japonicus-molecular characterization and transcriptional response to Vibrio splendidus infection.
Infections
Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.
Infections
Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.
Infections
Cathepsin L proteinases as vaccines against infection with Fasciola hepatica (liver fluke) in ruminants.
Infections
Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini.
Infections
Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection.
Infections
Cronobacter sakazakii ATCC 29544 Translocated Human Brain Microvascular Endothelial Cells via Endocytosis, Apoptosis Induction, and Disruption of Tight Junction.
Infections
Development and validation of an RNA- and DNA-based quantitative PCR assay for determination of Kudoa thyrsites infection levels in Atlantic salmon Salmo salar.
Infections
Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes.
Infections
Dissociation of ras oncogene-induced gene expression and anchorage-independent growth in a series of somatic cell mutants.
Infections
DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis.
Infections
Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease.
Infections
Ectromelia virus suppresses expression of cathepsins and cystatins in conventional dendritic cells to efficiently execute the replication process.
Infections
Encapsulation of Cwp84 into pectin beads for oral vaccination against Clostridium difficile.
Infections
Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis.
Infections
Fasciola gigantica cathepsin-L cysteine proteinase in the detection of early experimental fasciolosis in ruminants.
Infections
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses.
Infections
High genetic diversity in field isolates of Trypanosoma theileri assessed by analysis of cathepsin L-like sequences disclosed multiple and new genotypes infecting cattle in Thailand.
Infections
Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus-2 Release from Cells.
Infections
Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide.
Infections
Identification, mRNA expression profiling and activity characterization of cathepsin L from red drum (Sciaenops ocellatus).
Infections
Immunization of hamsters against Clostridium difficile infection using the Cwp84 protease as an antigen.
Infections
Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases.
Infections
Immunodiagnosis of Fasciola hepatica infection (fascioliasis) in a human population in the Bolivian Altiplano using purified cathepsin L cysteine proteinase.
Infections
Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.
Infections
Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin.
Infections
Influence of environmental conditions on the expression and the maturation process of the Clostridium difficile surface associated protease Cwp84.
Infections
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Infections
Linker Editing of Pneumococcal Lysin ClyJ Conveys Improved Bactericidal Activity.
Infections
Loop-mediated isothermal amplification method for differentiation and rapid detection of Taenia species.
Infections
Modulation of Rumen Microbes Through Extracellular Vesicle Released by the Rumen Fluke Calicophoron daubneyi.
Infections
Novel Non-Peptide Inhibitors against SmCL1 of Schistosoma mansoni: In Silico Elucidation, Implications and Evaluation via Knowledge Based Drug Discovery.
Infections
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Infections
Porcine deltacoronavirus enters cells via two pathways: A protease-mediated one at the cell surface and another facilitated by cathepsins in the endosome.
Infections
Processing of capsid protein by cathepsin L plays a crucial role in replication of Japanese encephalitis virus in neural and macrophage cells.
Infections
Protection against Fasciola gigantica infection in mice by vaccination with recombinant juvenile-specific cathepsin L.
Infections
Rapid identification of lymnaeid snails and their infection with Fasciola gigantica in Thailand.
Infections
Recognition Pattern of the Fasciola hepatica Excretome/Secretome during the Course of an Experimental Infection in Sheep by 2D Immunoproteomics.
Infections
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.
Infections
Serodiagnosis of Fasciola gigantica Infection in Buffaloes with Native Cathepsin-L Proteases and Recombinant Cathepsin L1-D.
Infections
Snake venom-derived bradykinin-potentiating peptides: A promising therapy for COVID-19?
Infections
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
Infections
The first characterization of a cystatin and a cathepsin L-like peptidase from Aedes aegypti and their possible role in DENV infection by the modulation of apoptosis.
Infections
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
Infections
TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.
Infections
Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy.
Infections
Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.
Infections
[Cathepsin L Cysteine Protease from Taenia solium: Its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis.]
Infertility
Expression of cathepsin L in human testis under diverse infertility conditions.
Infertility, Male
Expression of cathepsin L in human testis under diverse infertility conditions.
Intestinal Neoplasms
Tumor cell- and microenvironment-specific roles of cysteine cathepsins in mouse models of human cancers.
Intestinal Volvulus
Cathepsin L is essential for embryogenesis and development of Caenorhabditis elegans.
Intestinal Volvulus
RNA interference targeting cathepsin L and Z-like cysteine proteases of Onchocerca volvulus confirmed their essential function during L3 molting.
Keratosis, Seborrheic
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Kidney Diseases
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Kidney Neoplasms
Cloning, genomic organization, and chromosomal localization of human cathepsin L.
Leg Ulcer
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Leishmaniasis
Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.
Leishmaniasis
Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.
Leishmaniasis
Improving serodiagnosis of human and canine leishmaniasis with recombinant Leishmania braziliensis cathepsin l-like protein and a synthetic peptide containing its linear B-cell epitope.
Leishmaniasis
Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice.
Leishmaniasis, Visceral
Canine Visceral Leishmaniasis in São Paulo, Brazil, the Most Populous City of South America: Isolation, Molecular Diagnosis, and Phylogenetic Inferences.
Leishmaniasis, Visceral
Cationic solid lipid nanoparticles loaded by cysteine proteinase genes as a novel anti-leishmaniasis DNA vaccine delivery system: characterization and in vitro evaluations.
Leukemia
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Epigenetic Regulation of Cathepsin L Expression in Chronic Myeloid Leukemia.
Leukemia, Myeloid, Acute
Prognostic significance of cathepsin L expression in pediatric acute myeloid leukemia.
Lichen Planus
Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.
Liver Cirrhosis
Cathepsin L and B as Potential Markers for Liver Fibrosis: Insights From Patients and Experimental Models.
Liver Diseases
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Lung Diseases
Analysis of the Proteolytic Processing of ABCA3: Identification of Cleavage Site and Involved Proteases.
Lung Injury
A novel zebrafish model to emulate lung injury by folate deficiency-induced swim bladder defectiveness and protease/antiprotease expression imbalance.
Lung Neoplasms
Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.
Lung Neoplasms
Detection of cathepsin B, cathepsin L, cystatin C, urokinase plasminogen activator and urokinase plasminogen activator receptor in the sera of lung cancer patients.
Lung Neoplasms
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Lung Neoplasms
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
Lung Neoplasms
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium.
Lung Neoplasms
Overexpression of Cathepsin L is associated with gefitinib resistance in non-small cell lung cancer.
Lung Neoplasms
Quantification of intracellular cathepsin activities in human lung tumor cell lines by flow cytometry.
Lung Neoplasms
Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines.
Lymphatic Metastasis
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Lymphoma
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases.
Lymphoma
Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA.
Lymphoma
Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms.
Lymphoma, Non-Hodgkin
Cystatin C in LS lymphosarcoma and HA-1 hepatoma treated with Ukrain and cyclophosphamide and involvement of apoptosis.
Lysosomal Storage Diseases
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Malaria
Independent amino acid residues in the S2 pocket of falcipain-3 determine its specificity for P2 residues in substrates.
Malaria
Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth.
Melanoma
Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis.
Melanoma
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Melanoma
Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region.
Melanoma
Characterization of human cathepsin L promoter and identification of binding sites for NF-Y, Sp1 and Sp3 that are essential for its activity.
Melanoma
Cloning and characterization of anti-cathepsin L single chain variable fragment whose expression inhibits procathepsin L secretion in human melanoma cells.
Melanoma
Effect of cysteine proteinase inhibitors on murine B16 melanoma cell invasion in vitro.
Melanoma
Expression and prognostic significance of Cathepsin L in early cutaneous malignant melanoma.
Melanoma
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Melanoma
Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms.
Melanoma
Melanoma Growth and Progression After Ultraviolet A Irradiation: Impact of Lysosomal Exocytosis and Cathepsin Proteases.
Melanoma
Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis.
Melanoma
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Melanoma
Tumor-associated cysteine proteinase activities in human melanoma cells and fibroblasts of different origin.
Meningioma
Cathepsins B and L and their inhibitors stefin B and cystatin C as markers for malignant progression of benign meningiomas.
Meningioma
Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors.
Meningitis, Pneumococcal
Phage lytic enzyme Cpl-1 for antibacterial therapy in experimental pneumococcal meningitis.
Mouth Neoplasms
PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial-Mesenchymal Transition.
Mouth Neoplasms
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.
Mouth Neoplasms
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
Mouth Neoplasms
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer.
Mucolipidoses
Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.
Muscular Atrophy
Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt.
Muscular Atrophy
Conditional activation of MET in differentiated skeletal muscle induces atrophy.
Muscular Atrophy
Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle.
Muscular Atrophy
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Muscular Atrophy
Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control.
Muscular Atrophy
Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells.
Muscular Diseases
Pharmacological activation of the pyruvate dehydrogenase complex reduces statin-mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents.
Mycoplasma Infections
Cathepsin L promotes secretory IgA response by participating in antigen presentation pathways during Mycoplasma Hyopneumoniae infection.
Myocardial Infarction
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
Myocardial Ischemia
[Cathepsin L expression in plasma after acute myocardial ischemia and ischemia-reperfusion in rats].
Nasopharyngeal Carcinoma
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Neoplasm Metastasis
A micRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial-mesenchymal transition.
Neoplasm Metastasis
Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice.
Neoplasm Metastasis
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Neoplasm Metastasis
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion.
Neoplasm Metastasis
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.
Neoplasm Metastasis
Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94.
Neoplasm Metastasis
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model.
Neoplasm Metastasis
Cathepsin L induces proangiogenic changes in human omental microvascular endothelial cells via activation of the ERK1/2 pathway.
Neoplasm Metastasis
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Neoplasm Metastasis
Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder.
Neoplasm Metastasis
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer.
Neoplasm Metastasis
Cathepsin L secretion by host and neoplastic cells potentiates invasion.
Neoplasm Metastasis
Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells.
Neoplasm Metastasis
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Neoplasm Metastasis
Characterization of downstream Ras signals that induce alternative protease-dependent invasive phenotypes.
Neoplasm Metastasis
Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma.
Neoplasm Metastasis
Clinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasis.
Neoplasm Metastasis
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Neoplasm Metastasis
Differential activity of cathepsin L in human placenta at two different stages of gestation.
Neoplasm Metastasis
Effect of liver macrophage depression on the development of liver metastases of HA-1 tumor in mice.
Neoplasm Metastasis
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Neoplasm Metastasis
Expression of Cathepsin B and L antigen and activity is associated with early colorectal cancer progression.
Neoplasm Metastasis
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Neoplasm Metastasis
Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
Neoplasm Metastasis
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Neoplasm Metastasis
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells.
Neoplasm Metastasis
Identification of low-risk node-negative breast cancer patients by tumor biological factors PAI-1 and cathepsin L.
Neoplasm Metastasis
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Neoplasm Metastasis
Increased expression of cathepsins L and B and decreased activity of their inhibitors in metastatic, ras-transformed NIH 3T3 cells.
Neoplasm Metastasis
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Neoplasm Metastasis
Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth.
Neoplasm Metastasis
Molecular cloning and anti-invasive activity of cathepsin L propeptide-like protein from Calotropis procera R. Br. against cancer cells.
Neoplasm Metastasis
Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer.
Neoplasm Metastasis
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.
Neoplasm Metastasis
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Neoplasm Metastasis
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Neoplasm Metastasis
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
Neoplasm Metastasis
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Neoplasm Metastasis
Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.
Neoplasm Metastasis
The heparanase system and tumor metastasis: is heparanase the seed and soil?
Neoplasm Metastasis
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Neoplasm Metastasis
Truncated Human Cathepsin L, Encoded by a Novel Splice Variant, Exhibits Altered Subcellular Localization and Cytotoxicity.
Neoplasm Metastasis
[Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells.]
Neoplasms
A Cathepsin-L is required for invasive behavior during Air Sac Primordium development in Drosophila melanogaster.
Neoplasms
A heparin binding motif on the pro-domain of human procathepsin L mediates zymogen destabilization and activation.
Neoplasms
A micRNA-200c/cathepsin L feedback loop determines paclitaxel resistance in human lung cancer A549 cells in vitro through regulating epithelial-mesenchymal transition.
Neoplasms
Altered gene expression profiles of NIH3T3 cells regulated by human lung cancer associated gene CT120.
Neoplasms
An Active 32-kDa Cathepsin L Is Secreted Directly from HT 1080 Fibrosarcoma Cells and Not via Lysosomal Exocytosis.
Neoplasms
Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells.
Neoplasms
Assessment of cathepsin L activity by use of the inhibitor CA-074 compared to cathepsin B activity in human lung tumor tissue.
Neoplasms
Association of Epithelial Mesenchymal Transition with prostate and breast health disparities.
Neoplasms
Biomarkers Associated With Tumor Ki67 and Cathepsin L Gene Expression in Prostate Cancer Patients Participating in a Presurgical Weight Loss Trial.
Neoplasms
Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion.
Neoplasms
Cathepsin B activity in human lung tumor cell lines: ultrastructural localization, pH sensitivity, and inhibitor status at the cellular level.
Neoplasms
Cathepsin B promotes the progression of pancreatic ductal adenocarcinoma in mice.
Neoplasms
Cathepsin expression in oral squamous cell carcinoma: relationship with clinicopathologic factors.
Neoplasms
Cathepsin L activated by mutant p53 and Egr-1 promotes ionizing radiation-induced EMT in human NSCLC.
Neoplasms
Cathepsin L affects apoptosis of glioblastoma cells: a potential implication in the design of cancer therapeutics.
Neoplasms
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.
Neoplasms
Cathepsin L expression is up-regulated by hypoxia in human melanoma cells: role of its 5'-untranslated region.
Neoplasms
Cathepsin L in tumor angiogenesis and its therapeutic intervention by the small molecule inhibitor KGP94.
Neoplasms
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model.
Neoplasms
Cathepsin L inhibition by the small molecule KGP94 suppresses tumor microenvironment enhanced metastasis associated cell functions of prostate and breast cancer cells.
Neoplasms
Cathepsin L inhibition suppresses drug resistance in vitro and in vivo: a putative mechanism.
Neoplasms
Cathepsin L is associated with proliferation and clinical outcome of urothelial carcinoma of the bladder.
Neoplasms
Cathepsin L is involved in X-ray-induced invasion and migration of human glioma U251 cells.
Neoplasms
Cathepsin L knockdown enhances curcumin-mediated inhibition of growth, migration, and invasion of glioma cells.
Neoplasms
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer.
Neoplasms
Cathepsin L promotes ionizing radiation-induced U251 glioma cell migration and invasion through regulating the GSK-3?/CUX1 pathway.
Neoplasms
Cathepsin L suppression increases the radiosensitivity of human glioma U251 cells via G2/M cell cycle arrest and DNA damage.
Neoplasms
Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells.
Neoplasms
Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.
Neoplasms
Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms.
Neoplasms
Cathepsin L2, a novel human cysteine proteinase produced by breast and colorectal carcinomas.
Neoplasms
Cathepsin-B and cathepsin-L expression levels do not correlate with sensitivity of tumour cells to TNF-alpha-mediated apoptosis.
Neoplasms
Cathepsins D, B and L in breast carcinoma and in transformed human breast epithelial cells (HBEC).
Neoplasms
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Neoplasms
CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-?) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Neoplasms
Cells producing cathepsins D, B, and L in human breast carcinoma and their association with prognosis.
Neoplasms
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Neoplasms
Clinical Relevance of Increased Endothelial and Mesothelial Expression of Proangiogenic Proteases and VEGFA in the Omentum of Patients with Metastatic Ovarian High-Grade Serous Carcinoma.
Neoplasms
Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.
Neoplasms
Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression.
Neoplasms
Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.
Neoplasms
Cystatin E/M Suppresses Tumor Cell Growth through Cytoplasmic Retention of NF-?B.
Neoplasms
Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.
Neoplasms
Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smoking.
Neoplasms
Cysteine proteinases in cancer progression and their clinical relevance for prognosis.
Neoplasms
Deficiency for the cysteine protease cathepsin L impairs Myc-induced tumorigenesis in a mouse model of pancreatic neuroendocrine cancer.
Neoplasms
Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.
Neoplasms
Differential activity of cathepsin L in human placenta at two different stages of gestation.
Neoplasms
Dioxin-mediated tumor progression through activation of mitochondria-to-nucleus stress signaling.
Neoplasms
Downregulation of cathepsin L suppresses cancer invasion and migration by inhibiting transforming growth factor???mediated epithelial?mesenchymal transition.
Neoplasms
Downstream sequences mediate induction of the mouse cathepsin L promoter by phorbol esters.
Neoplasms
Dynamic Model of Protease State and Inhibitor Trafficking to Predict Protease Activity in Breast Cancer Cells.
Neoplasms
Effect of in-situ and ex-situ biofloc on immune response of Genetically Improved Farmed Tilapia.
Neoplasms
Effective activation of the proenzyme form of the urokinase-type plasminogen activator (pro-uPA) by the cysteine protease cathepsin L.
Neoplasms
Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues.
Neoplasms
Enhancing effect of new biological response modifier sulfoethylated (1-->3)-beta-D-glucan on antitumor activity of cyclophosphamide in the treatment of experimental murine leukoses.
Neoplasms
Epithelial-Mesenchymal Transition (EMT) Protein Expression in a Cohort of Stage II Colorectal Cancer Patients With Characterized Tumor Budding and Mismatch Repair Protein Status.
Neoplasms
Expression and immunohistochemical localization of cathepsin L during the progression of human gliomas.
Neoplasms
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Neoplasms
Expression of cathepsin L in human tumor cells is under the control of distinct regulatory mechanisms.
Neoplasms
Expression of cathepsin L in nasopharyngeal carcinoma and its clinical significance.
Neoplasms
Expression of Cathepsin L in tumor cells and tumor-associated macrophages in patients with Ewing sarcoma family of tumors: a pilot study.
Neoplasms
Expression of genes that contribute to proliferative and metastatic ability in breast cancer resected during various menstrual phases.
Neoplasms
Expression profile of cathepsins indicates the potential of cathepsins B and D as prognostic factors in breast cancer patients.
Neoplasms
Expression, proliferation activity and clinical significance of cathepsin B and cathepsin L in operated lung cancer.
Neoplasms
Gelatin Zymography Using Leupeptin for the Detection of Various Cathepsin L Forms.
Neoplasms
Graphene Oxide-Based Targeting of Extracellular Cathepsin D and Cathepsin L As A Novel Anti-Metastatic Enzyme Cancer Therapy.
Neoplasms
High levels of cathepsin D and cystatin B are associated with increased risk of coronary events.
Neoplasms
Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth.
Neoplasms
Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting.
Neoplasms
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells.
Neoplasms
Identification of low-risk node-negative breast cancer patients by tumor biological factors PAI-1 and cathepsin L.
Neoplasms
Identification of secreted glycoproteins of human prostate and bladder stromal cells by comparative quantitative proteomics.
Neoplasms
Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus.
Neoplasms
Immunohistochemical localization of cathepsin L and cystatin A in normal skin and skin tumors.
Neoplasms
Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma.
Neoplasms
In silico investigation of heparanase-correlated genes in breast cancer subtypes.
Neoplasms
In vivo imaging of intraperitoneally disseminated tumors in model mice by using activatable fluorescent small-molecular probes for activity of cathepsins.
Neoplasms
Increased cathepsin L levels in serum in some patients with ovarian cancer: comparison with CA125 and CA72-4.
Neoplasms
Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation.
Neoplasms
Increased levels of cathepsin B and L, urokinase-type plasminogen activator and its inhibitor type-1 as an early event in gastric carcinogenesis.
Neoplasms
Influence of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE) on the localization of cathepsin B and cathepsin L in human lung tumor cells.
Neoplasms
Inhibition of cathepsin L sensitizes human glioma cells to ionizing radiation in vitro through NF-?B signaling pathway.
Neoplasms
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
Neoplasms
Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins.
Neoplasms
K-ras mutation promotes ionizing radiation-induced invasion and migration of lung cancer in part via the Cathepsin L/CUX1 pathway.
Neoplasms
Knockdown of Cathepsin L promotes radiosensitivity of glioma stem cells both in vivo and in vitro.
Neoplasms
Levels of the Autophagy Related 5 Protein Affect Progression and Metastasis of Pancreatic Tumors in Mice.
Neoplasms
Localization of nuclear cathepsin L and its association with disease progression and poor outcome in colorectal cancer.
Neoplasms
Loss of cathepsin L activity promotes claudin-1 overexpression and intestinal neoplasia.
Neoplasms
Loss of the endothelial glycocalyx is associated with increased E-selectin mediated adhesion of lung tumour cells to the brain microvascular endothelium.
Neoplasms
Lysosomal cathepsins B and L and Stefin A blood levels in patients with hepatocellular carcinoma and/or liver cirrhosis: potential clinical implications.
Neoplasms
Malignant transformation and tumor promoter treatment increase levels of a transcript for a secreted glycoprotein.
Neoplasms
Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth.
Neoplasms
MicroRNA-152 inhibits tumor cell growth while inducing apoptosis via the transcriptional repression of cathepsin L in gastrointestinal stromal tumor.
Neoplasms
Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells.
Neoplasms
Modeling of Halogen-Protein Interactions in Co-Solvent Molecular Dynamics Simulations.
Neoplasms
Molecular cloning and anti-invasive activity of cathepsin L propeptide-like protein from Calotropis procera R. Br. against cancer cells.
Neoplasms
Multiple lysosomal trafficking phenotypes in metastatic mouse mammary tumor cell lines.
Neoplasms
Muscadine grape skin extract can antagonize Snail-cathepsin L-mediated invasion, migration and osteoclastogenesis in prostate and breast cancer cells.
Neoplasms
Non-peptidic Cruzain Inhibitors with Trypanocidal Activity Discovered by Virtual Screening and In Vitro Assay.
Neoplasms
Novel Non-Congeneric Derivatives of the Choline Kinase Alpha Inhibitor ICL-CCIC-0019.
Neoplasms
Overexpression of Cathepsin L is associated with chemoresistance and invasion of epithelial ovarian cancer.
Neoplasms
P300 Participates in Ionizing Radiation-Mediated Activation of Cathepsin L by Mutant p53.
Neoplasms
PlatyphyllenoneExerts Anti-Metastatic Effects on Human Oral Cancer Cells by Modulating Cathepsin L Expression, MAPK Pathway and Epithelial-Mesenchymal Transition.
Neoplasms
Possible contribution of active MMP2 to lymph-node metastasis and secreted cathepsin L to bone invasion of newly established human oral-squamous-cancer cell lines.
Neoplasms
Presence of activated ras correlates with increased cysteine proteinase activities in human colorectal carcinomas.
Neoplasms
Processing and lysosomal localization of a glycoprotein whose secretion is transformation stimulated.
Neoplasms
Prognostic significance of cathepsin L expression in pediatric acute myeloid leukemia.
Neoplasms
Prognostic significance of cysteine proteinases cathepsins B and L and their endogenous inhibitors stefins A and B in patients with squamous cell carcinoma of the head and neck.
Neoplasms
Prognostic significance of extracellular matrix degrading enzymes-cathepsin L and matrix metalloproteases-2 [MMP-2] in human pancreatic cancer.
Neoplasms
Prognostic value of cathepsins B, H, L, D and their endogenous inhibitors stefins A and B in head and neck carcinoma.
Neoplasms
Prognostic value of the cysteine proteases cathepsins B and cathepsin L in human breast cancer.
Neoplasms
Protein C inhibitor regulates both cathepsin L activity and cell-mediated tumor cell migration.
Neoplasms
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
Neoplasms
ras mutation and expression of the ras-regulated genes osteopontin and cathepsin L in human esophageal cancer.
Neoplasms
Recombinant cathepsin S propeptide attenuates cell invasion by inhibition of cathepsin L-like proteases in tumor microenvironment.
Neoplasms
Relation between the regulation of DNA synthesis and the production of two secreted glycoproteins by 12-O-tetradecanoylphorbol-13-acetate in 3T3 cells and in phorbol ester nonresponsive 3T3 variants.
Neoplasms
RNA interference targeting CML66, a novel tumor antigen, inhibits proliferation, invasion and metastasis of HeLa cells.
Neoplasms
Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosis.
Neoplasms
Sequential enzyme-activated macrotheranostic probe for selective tumor mitochondria targeting.
Neoplasms
Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks.
Neoplasms
Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L.
Neoplasms
Structural basis for reversible and irreversible inhibition of human cathepsin L by their respective dipeptidyl glyoxal and diazomethylketone inhibitors.
Neoplasms
Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.
Neoplasms
Suppression by cathepsin L inhibitors of the invasion of amnion membranes by murine cancer cells.
Neoplasms
Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice.
Neoplasms
Synthesis and biochemical evaluation of benzoylbenzophenone thiosemicarbazone analogues as potent and selective inhibitors of cathepsin L.
Neoplasms
Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L.
Neoplasms
Synthesis and evaluation of N?,N?-diacetyl-l-lysine-inositol conjugates as cancer-selective probes for metabolic engineering of GPIs and GPI-anchored proteins.
Neoplasms
Synthesis and Preclinical Evaluation of a Highly Improved Anticancer Prodrug Activated by Histone Deacetylases and Cathepsin L.
Neoplasms
Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy.
Neoplasms
Targeting the Nuclear Cathepsin L CCAAT Displacement Protein/Cut Homeobox Transcription Factor-Epithelial Mesenchymal Transition Pathway in Prostate and Breast Cancer Cells with the Z-FY-CHO Inhibitor.
Neoplasms
The Expression of Lysosomal Proteinases and Their Inhibitors in Breast Cancer: Possible Relationship to Prognosis of the Disease.
Neoplasms
The identification of active forms of cysteine proteinases in Kirsten-virus-transformed mouse fibroblasts by use of a specific radiolabelled inhibitor.
Neoplasms
The influence of Ukrain on the growth of HA-1 tumor in mice: the role of cysteine proteinases as markers of tumor malignancy.
Neoplasms
The major excreted protein of transformed fibroblasts is an activable acid-protease.
Neoplasms
Toward understanding recurrent meningioma: the potential role of lysosomal cysteine proteases and their inhibitors.
Neoplasms
Transcription of human cathepsin L mRNA species hCATL B from a novel alternative promoter in the first intron of its gene.
Neoplasms
Truncated Human Cathepsin L, Encoded by a Novel Splice Variant, Exhibits Altered Subcellular Localization and Cytotoxicity.
Neoplasms
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
Neoplasms
Tumor progression and metastasis in murine D2 hyperplastic alveolar nodule mammary tumor cell lines.
Neoplasms
Tumor promoters increase the synthesis of a 32,000-dalton protein in BALB/c 3T3 cells.
Neoplasms
Wild type p53-dependent transcriptional upregulation of cathepsin L expression is mediated by C/EBPα in human glioblastoma cells.
Neoplasms
[Prognostic implications of biologic markers in intracranial meningiomas: 120 cases]
Neoplasms
[Prognostic significance of determining cathepsin B activity in malignant ovarian tumors]
Neoplasms, Germ Cell and Embryonal
Expression of cathepsin L in human testis under diverse infertility conditions.
Nephritis, Interstitial
Identification and characterization of the interactive proteins with cytotoxic T-lymphocyte antigen-2?
Nephrosis
Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli of Rats With Puromycin Aminonucleoside Nephrosis.
Nephrosis
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin.
Nephrotic Syndrome
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin.
Neuroblastoma
Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells.
Neuroblastoma
Identification of secreted proteins regulated by cAMP in glioblastoma cells using glycopeptide capture and label-free quantification.
Neurocysticercosis
[Cathepsin L Cysteine Protease from Taenia solium: Its biological role in the infection and potential use for the immunodiagnosis of neurocysticercosis.]
Neurodegenerative Diseases
Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease.
Neuroinflammatory Diseases
Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-?B pathways.
Neuronal Ceroid-Lipofuscinoses
Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis.
Neuronal Ceroid-Lipofuscinoses
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis.
Nevus
TGF-? signaling, activated stromal fibroblasts, and cysteine cathepsins B and L drive the invasive growth of human melanoma cells.
Non-alcoholic Fatty Liver Disease
Mir214-3p and Hnf4a/Hnf4? reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis.
Obesity
Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.
Osteoarthritis
Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Osteoarthritis
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis.
Osteoarthritis
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Osteoporosis
Caught in the act: the crystal structure of cleaved cathepsin L bound to the active site of Cathepsin L.
Osteoporosis
Structure-based development of cathepsin L inhibitors and therapeutic applications for prevention of cancer metastasis and cancer-induced osteoporosis.
Osteosarcoma
Cathepsin L antisense oligonucleotides in a human osteosarcoma cell line: effects on the invasive phenotype.
Ovarian Neoplasms
Cathepsin L is involved in proliferation and invasion of ovarian cancer cells.
Ovarian Neoplasms
Clinical value of combined detection of serum matrix metalloproteinase-9, heparanase, and cathepsin for determining ovarian cancer invasion and metastasis.
Ovarian Neoplasms
Combined detection of serum matrix metalloproteinase 9, acetyl heparinase and cathepsin L in diagnosis of ovarian cancer.
Ovarian Neoplasms
Increased cathepsin L levels in serum in some patients with ovarian cancer: comparison with CA125 and CA72-4.
Ovarian Neoplasms
Knockdown of cathepsin L sensitizes ovarian cancer cells to chemotherapy.
Ovarian Neoplasms
Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer.
Ovarian Neoplasms
Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death.
Ovarian Neoplasms
Serum HE4, CA125, YKL-40, bcl-2, cathepsin-L and prediction optimal debulking surgery, response to chemotherapy in ovarian cancer.
Ovarian Neoplasms
The application value of the detection of the level of tissue polypeptide antigen, ovarian cancer antigen X1, cathepsin L and CA125 on the diagnosis of epithelial ovarian cancer.
Ovarian Neoplasms
[Relationship between cathepsin L and invasion and metastasis of ovarian carcinoma cells.]
Pancreatic Neoplasms
Characterization of a cathepsin L-like enzyme secreted from human pancreatic cancer cell line HPC-YP.
Pancreatitis
Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.
Pancreatitis
Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis.
Pancreatitis
Transgenic expression of GFP-LC3 perturbs autophagy in exocrine pancreas and acute pancreatitis responses in mice.
Papillon-Lefevre Disease
Epidermal differentiation: the role of proteases and their inhibitors.
Parasitic Diseases
Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease.
Parkinson Disease
Cathepsin L is involved in 6-hydroxydopamine induced apoptosis of SH-SY5Y neuroblastoma cells.
Parkinson Disease
Parkinson's disease involves autophagy and abnormal distribution of cathepsin L.
Parkinson Disease
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective.
Periodontitis
Cathepsin B- and L-like activities at local gingival sites of chronic periodontitis patients.
Periodontitis
Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients.
Persistent Infection
Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.
Persistent Infection
Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA).
Pneumococcal Infections
Comprehensive evaluation of chitosan nanoparticle based phage lysin delivery system; a novel approach to counter S. pneumoniae infections.
Pneumonia, Pneumococcal
Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia.
Pneumonia, Pneumococcal
Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia.
Polycystic Kidney, Autosomal Dominant
Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1.
Prostatic Neoplasms
Association of Epithelial Mesenchymal Transition with prostate and breast health disparities.
Prostatic Neoplasms
Biomarkers Associated With Tumor Ki67 and Cathepsin L Gene Expression in Prostate Cancer Patients Participating in a Presurgical Weight Loss Trial.
Prostatic Neoplasms
Biotechnological Potential of Araucaria angustifolia Pine Nuts Extract and the Cysteine Protease Inhibitor AaCI-2S.
Prostatic Neoplasms
Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model.
Prostatic Neoplasms
Quantitative Glycoproteomic Analysis of Optimal Cutting Temperature-Embedded Frozen Tissues Identifying Glycoproteins Associated with Aggressive Prostate Cancer.
Prostatic Neoplasms
Snail transcription factor NLS and importin ?1 regulate the subcellular localization of Cathepsin L and Cux1.
Proteinuria
Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans.
Proteinuria
Cathepsin L is crucial for the development of early experimental diabetic nephropathy.
Proteinuria
Evidence suggesting a role for cathepsin L in an experimental model of glomerulonephritis.
Proteinuria
Expression of Cathepsin L and Its Intrinsic Inhibitors in Glomeruli of Rats With Puromycin Aminonucleoside Nephrosis.
Proteinuria
Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.
Psoriasis
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Pulmonary Disease, Chronic Obstructive
Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.
Pulmonary Disease, Chronic Obstructive
Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections.
Pulmonary Emphysema
Uptake of extracellular enzyme by a novel pathway is a major determinant of cathepsin L levels in human macrophages.
Pyoderma Gangrenosum
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Renal Insufficiency, Chronic
Cathepsin L activity correlates with proteinuria in chronic kidney disease in humans.
Reoviridae Infections
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.
Reoviridae Infections
Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.
Reperfusion Injury
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
Retinal Degeneration
Cathepsin proteases mediate photoreceptor cell degeneration in Drosophila.
Sarcoma
Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.
Sarcoma
Differences in targeting and secretion of cathepsins B and L by BALB/3T3 fibroblasts and Moloney murine sarcoma virus-transformed BALB/3T3 fibroblasts.
Sarcoma
Enzymatic detection systems for non-isotopic in situ hybridization using biotinylated cDNA probes.
Sarcoma
Retrovirus transformation associated secretory phosphoproteins of mouse and mink cells.
Sarcoma, Ewing
Expression of Cathepsin L in tumor cells and tumor-associated macrophages in patients with Ewing sarcoma family of tumors: a pilot study.
Sarcoma, Yoshida
Identification of cathepsin L as a differentially expressed message associated with skeletal muscle wasting.
Schistosomiasis
Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases.
Scleroderma, Systemic
A potential contribution of altered cathepsin L expression to the development of dermal fibrosis and vasculopathy in systemic sclerosis.
Sepsis
Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.
Sepsis
Phage lytic enzymes as therapy for antibiotic-resistant Streptococcus pneumoniae infection in a murine sepsis model.
Sepsis
Sepsis causes right ventricular myocardial inflammation independent of pulmonary hypertension in a porcine sepsis model.
Sertoli Cell-Only Syndrome
Expression of cathepsin L in human testis under diverse infertility conditions.
Severe Acute Respiratory Syndrome
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Severe Acute Respiratory Syndrome
Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites.
Severe Acute Respiratory Syndrome
Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level.
Severe Acute Respiratory Syndrome
Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide.
Severe Acute Respiratory Syndrome
Cathepsin L in COVID-19: From Pharmacological Evidences to Genetics.
Severe Acute Respiratory Syndrome
Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.
Severe Acute Respiratory Syndrome
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry.
Skin Diseases
Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases.
Skin Diseases
Expression of the human Cathepsin L inhibitor hurpin in mice: skin alterations and increased carcinogenesis.
Spondylarthropathies
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Squamous Cell Carcinoma of Head and Neck
Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Quantitative analysis of cathepsin L mRNA and protein expression during oral cancer progression.
Squamous Cell Carcinoma of Head and Neck
The expression of Cathepsin L in oral lichen planus.
ST Elevation Myocardial Infarction
Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size.
Starvation
Coordinate upregulation of proteolytic-related genes in rat muscle during late fasting.
Starvation
Effect of fasting and thyroidectomy on cysteine proteinase activities in liver and muscle.
Starvation
Salmon spawning migration and muscle protein metabolism: the August Krogh principle at work.
Stomach Neoplasms
Cathepsin L promotes angiogenesis by regulating the CDP/Cux/VEGF-D pathway in human gastric cancer.
Stomach Neoplasms
FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L.
Tendinopathy
Sequential, but not Concurrent, Incubation of Cathepsin K and L with Type I Collagen Results in Extended Proteolysis.
Testicular Neoplasms
Expression of cathepsin L in human testis under diverse infertility conditions.
Thrombosis
Cathepsin D and cathepsin L activities in aortic aneurysm wall and parietal thrombus.
Thyroid Neoplasms
Influence of proliferation, differentiation and dedifferentiation factors on the expression of the lysosomal cysteine proteinase cathepsin L (CL) in thyroid cancer cell lines.
Thyroid Neoplasms
Relaxin enhances the oncogenic potential of human thyroid carcinoma cells.
Toxoplasmosis
Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.
Toxoplasmosis
Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.
Triple Negative Breast Neoplasms
CCAAT-displacement protein/cut homeobox transcription factor (CUX1) represses estrogen receptor-alpha (ER-?) in triple-negative breast cancer cells and can be antagonized by muscadine grape skin extract (MSKE).
Trypanosomiasis, African
Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
Tuberculosis
DM, but not cathepsin L, is required to control an aerosol infection with Mycobacterium tuberculosis.
Urinary Bladder Neoplasms
Role of urinary cathepsin B and L in the detection of bladder urothelial cell carcinoma.
Uterine Cervical Neoplasms
Cathepsin L mediates resveratrol-induced autophagy and apoptotic cell death in cervical cancer cells.
Uterine Cervical Neoplasms
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Uterine Cervical Neoplasms
Inactivation of the cystatin E/M tumor suppressor gene in cervical cancer.
Uterine Neoplasms
Increased cathepsin L levels in serum in some patients with ovarian cancer: comparison with CA125 and CA72-4.
Vascular Diseases
Cathepsin L deficiency results in reactive oxygen species (ROS) accumulation and vascular cells activation.
Vascular Diseases
Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells.
Vesicular Stomatitis
Characterization of the envelope glycoprotein of a novel filovirus, lloviu virus.
Vesicular Stomatitis
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells.
Viremia
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis.
Virus Diseases
A small-molecule oxocarbazate inhibitor of human cathepsin L blocks severe acute respiratory syndrome and ebola pseudotype virus infection into human embryonic kidney 293T cells.
Virus Diseases
Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Virus Diseases
Diminished intracellular invariant chain expression after vaccinia virus infection.
Virus Diseases
Identification and characterization of the v-cath gene of the baculovirus, CfMNPV.
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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.00236
2,6-dimethoxy-4-[4-(4-phenoxyphenyl)-5-phenyl-1H-imidazol-2-yl]phenol
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.02
2,6-dimethoxy-4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.02
2-(1,3-benzodioxol-5-yl)-5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.00241
2-(3,4-dimethoxyphenyl)-5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.02
2-(4-methoxyphenyl)-4-[8-[2-(4-methoxyphenyl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazole
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.02
2-(4-methoxyphenyl)-5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazole
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.02
2-(acetylamino)-N-[4-(6-[[2-(acetylamino)benzoyl]amino]-1H-benzimidazol-2-yl)phenyl]benzamide
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.02
2-(furan-2-yl)-4-[8-[2-(furan-2-yl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazole
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.00089
4,4'-[methanediylbis(1H-benzimidazole-5,2-diyl)]dianiline
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.02
4-(4-[8-[2-(4-carboxyphenyl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazol-2-yl)benzoic acid
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.00056
4-(4-[8-[2-(4-hydroxyphenyl)-4-phenyl-1H-imidazol-5-yl]dibenzo[b,d]furan-2-yl]-5-phenyl-1H-imidazol-2-yl)phenol
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.00215
4-amino-N-(4-[6-[(4-aminobenzoyl)amino]-1H-benzimidazol-2-yl]phenyl)benzamide
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.00178
4-[(E)-benzylideneamino]-N-[4-[6-([4-[(E)-benzylideneamino]benzoyl]amino)-1H-benzimidazol-2-yl]phenyl]benzamide
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.02
4-[4-(5,5-dioxidodibenzo[b,d]thiophen-2-yl)-5-phenyl-1H-imidazol-2-yl]-2,6-dimethoxyphenol
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.00047
4-[5-(4-[[2-(4-aminophenyl)-1H-benzimidazol-6-yl]oxy]phenoxy)-1H-benzimidazol-2-yl]aniline
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.02
4-[5-phenyl-4-[4-(phenylsulfanyl)phenyl]-1H-imidazol-2-yl]phenol
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.02
4-[8-(2,4-diphenyl-1H-imidazol-5-yl)dibenzo[b,d]furan-2-yl]-2,5-diphenyl-1H-imidazole)
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.00338
5-phenyl-4-[4-(phenylsulfanyl)phenyl]-2-(2,4,5-trimethoxyphenyl)-1H-imidazole
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.02
5-phenyl-4-[4-(phenylsulfanyl)phenyl]-2-(3,4,5-trimethoxyphenyl)-1H-imidazole
Trypanosoma brucei rhodesiense
above, pH 5.5, 25°C
0.0011
bis[2-(4-aminophenyl)-1H-benzimidazol-5-yl]methanone
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
0.00304
N-[4-(1H-benzimidazol-2-yl)phenyl]-2,2-diphenylacetamide
Trypanosoma brucei rhodesiense
pH 5.5, 25°C
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PDB
SCOP
CATH
UNIPROT
ORGANISM
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jefferson, T.; McShan, D.; Warfield, J.; Ogungbe, I.V.
Screening and identification of inhibitors of Trypanosoma brucei cathepsin L with antitrypanosomal activity
Chem. Biol. Drug Des.
87
154-158
2016
Homo sapiens (P07711), Homo sapiens, Trypanosoma brucei brucei (Q95PM0), Trypanosoma brucei rhodesiense (Q95PM0), Trypanosoma brucei brucei 427 (Q95PM0)
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Release 2023.1 (January 2023)
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