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Information on EC 3.4.21.B40 - kallikrein 9 and Organism(s) Rattus norvegicus and UniProt Accession P07647

for references in articles please use BRENDA:EC3.4.21.B40
preliminary BRENDA-supplied EC number
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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.B40 kallikrein 9
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This record set is specific for:
Rattus norvegicus
UNIPROT: P07647
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
proteolytic cleavage of polypeptides, preferential cleavage site at paired basic amino acid residues
Synonyms
egf-bp, epidermal growth factor-binding protein, egf-binding protein, hmw-egf, kallikrein 9, epidermal growth factor urogastrone, human tissue kallikrein 9, high molecular weight epidermal growth factor, s3 kallikrein, kallikrein-related peptidase 9, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S3 kallikrein
-
submandibular enzymatic vasocontrictor
-
tissue kallikrein
-
kallikrein 9
-
has chymotrypsin-like substrate specificity in addition to trypsin-like specificity
S01.307
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
9001-01-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-aminobenzoyl-TSVIRRVQ-ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
gurmarin + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-SVIRRVQ-ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
o-aminobenzoyl-TSVIRRPQ-ethylenediamine + H2O
?
show the reaction diagram
-
-
-
-
?
p-toluenesulfonyl-L-arginine methyl ester + H2O
p-toluenesulfonyl-L-arginine + methyl alcohol
show the reaction diagram
-
-
-
-
?
polypeptide + H2O
peptides
show the reaction diagram
-
-
-
?
additional information
?
-
-
rK9 is able to accommodate aromatic residues in position P1, and prefer a prolyl and hydrophobic residues in position P2'
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
polypeptide + H2O
peptides
show the reaction diagram
-
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0016
o-aminobenzoyl-TSVIRRVQ-ethylenediamine
-
o-aminobenzoyl-TSVIRRVQ-ethylenediamine
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
gene KLK9, submandibular glandular kallikrein 9 precursor
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
KLK9_RAT
259
0
28368
Swiss-Prot
-
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
DEAE column chromatography
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
The SWISS-PROT protein knowledgebase and its supplement TrEMBL
Nucleic Acids Res.
31
365-370
2003
Homo sapiens (Q9UKQ9), Mus musculus (P15949), Rattus norvegicus (P07647)
Manually annotated by BRENDA team
El Moujahed, A.; Brillard-Bourdet, M.; Juliano, M.A.; Moreau, T.; Chagas, J.R.; Gutman, N.; Prado, E.S.; Gauthier, F.
Kininogen-derived fluorogenic substrates for investigating the vasoactive properties of rat kallikreins. Identification of a T-kinin-releasing rat kallikrein
Eur. J. Biochem.
247
652-658
1997
Rattus norvegicus
Manually annotated by BRENDA team
Yamada, A.; Nakamura, Y.; Sugita, D.; Shirosaki, S.; Ohkuri, T.; Katsukawa, H.; Nonaka, K.; Imoto, T.; Ninomiya, Y.
Induction of salivary kallikreins by the diet containing a sweet-suppressive peptide, gurmarin, in the rat
Biochem. Biophys. Res. Commun.
346
386-392
2006
Rattus norvegicus
Manually annotated by BRENDA team