Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 3.4.21.98 - hepacivirin and Organism(s) Hepatitis C virus genotype 2a and UniProt Accession Q99IB8

for references in articles please use BRENDA:EC3.4.21.98
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.98 hepacivirin
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Hepatitis C virus genotype 2a
UNIPROT: Q99IB8 not found.
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'
Synonyms
ns3 protein, ns3/4a protease, hcv ns3, ns3/4a, hcv ns3 protease, hcv ns3/4a protease, ns3-4a, hcv ns3/4a, ns3-4a protease, ns3/4a serine protease, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
NS3
Hepatitis C virus genotype 2a
-
NS3 protease
Hepatitis C virus genotype 2a
-
NS3 serine protease
Hepatitis C virus genotype 2a
-
Cpro-2
-
-
-
-
Cpro-2 proteinase
-
-
-
-
Den2 protease
-
-
-
-
HCV NS3 protease
-
-
-
-
Hepacivirin
-
-
-
-
hepatitis C virus NS3 serine protease
-
-
-
-
NS2B-NS3 proteinase
-
-
-
-
NS3
-
-
-
-
NS3 protease
-
-
-
-
NS3 proteinase
-
-
-
-
NS3 serine protease
-
-
-
-
NS3 serine proteinase
-
-
-
-
NS3-4A serine protease complex
-
-
-
-
NS3-NS4A protease
-
-
-
-
NS5A-5B protease
-
-
-
-
P70
-
-
-
-
polyprotein-processing proteinase NS3
-
-
-
-
proteinase NS3
-
-
-
-
proteinase, polyprotein-processing, NS3
-
-
-
-
serine proteinase NS3
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
149885-80-3
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
Hepatitis C virus genotype 2a
NS3 acts as a serine protease and helicase
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
asunaprevir
Hepatitis C virus genotype 2a
-
BILN-2061
Hepatitis C virus genotype 2a
a NS3 serine protease inhibitor
boceprevir
Hepatitis C virus genotype 2a
-
deldeprevir
Hepatitis C virus genotype 2a
-
faldaprevir
Hepatitis C virus genotype 2a
-
grazoprevir
Hepatitis C virus genotype 2a
-
paritaprevir
Hepatitis C virus genotype 2a
-
simeprevir
Hepatitis C virus genotype 2a
-
telaprevir
Hepatitis C virus genotype 2a
-
vaniprevir
Hepatitis C virus genotype 2a
-
additional information
Hepatitis C virus genotype 2a
susceptibility/efficiency and resistance, respectively, of virus genotypes and variants with respect to antiviral agents, EC50 values, detailed overview
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Hepatitis C virus genotype 2a
HCV, isolate JFH-1
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
Hepatitis C virus genotype 2a
treatment of virus-infected cells with NS3 enzyme inhibitor BILN-2061 significantly increases degranulation against K-562 target cells and IFN-gamma productivity in natural killer (NK) cells of the host. The expression levels of activating NK cell receptors, such as NKp46 and NKp30, are also increased
physiological function
Hepatitis C virus genotype 2a
hepatitis C virus impairs natural killer cell activity via viral serine protease NS3. The modulation of natural killer (NK) cell functions by HCV leads to an impaired innate immune response. In HCV-infected Huh-7.5 cells, the serine protease NS3 may play a role in the abrogation of NK cell functions in the early phase of infection through downregulation of NKp46 and NKp30 receptors on NK cells. HCV-NS replicon and HCV-NS3-transfected Huh-7.5 cells attenuate NK cell functions, overview
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
A156G
Hepatitis C virus genotype 2a
virus mutant variant
A156S
Hepatitis C virus genotype 2a
virus mutant variant
A156T
Hepatitis C virus genotype 2a
virus mutant variant
A156V
Hepatitis C virus genotype 2a
virus mutant variant
D168A
Hepatitis C virus genotype 2a
virus mutant variant
D168E
Hepatitis C virus genotype 2a
virus mutant variant
D168G
Hepatitis C virus genotype 2a
virus mutant variant
D168H
Hepatitis C virus genotype 2a
virus mutant variant
D168N
Hepatitis C virus genotype 2a
virus mutant variant
D168V
Hepatitis C virus genotype 2a
virus mutant variant
R155A
Hepatitis C virus genotype 2a
virus mutant variant
R155E
Hepatitis C virus genotype 2a
virus mutant variant
R155G
Hepatitis C virus genotype 2a
virus mutant variant
R155H
Hepatitis C virus genotype 2a
virus mutant variant
R155K
Hepatitis C virus genotype 2a
virus mutant variant
R155Q
Hepatitis C virus genotype 2a
virus mutant variant
R155T
Hepatitis C virus genotype 2a
virus mutant variant
additional information
Hepatitis C virus genotype 2a
for hepatitis C virus (HCV) genotype 1, substitutions at NS3 protease positions 155, 156, and 168 are the main determinants of PI resistance. For other genotypes, similar substitutions are selected during protease inhibitor treatment but are not characterized systematically. Most mutant variants show decreased fitness compared to that of the original viruses. Fitness characteristics of HCV genotype 1 to 6 recombinants with substitutions at NS3P positions 155, 156, or 168, overview
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
genotyping, expression of wild-type and mutant variant viruses in Huh7.5 cells
Hepatitis C virus genotype 2a
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
drug development
Hepatitis C virus genotype 2a
NS3 protease represents a drug target for treatment of HCV infections
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jensen, S.B.; Serre, S.B.; Humes, D.G.; Ramirez, S.; Li, Y.P.; Bukh, J.; Gottwein, J.M.
Substitutions at NS3 residue 155, 156, or 168 of hepatitis C virus genotypes 2 to 6 induce complex patterns of protease inhibitor resistance
Antimicrob. Agents Chemother.
59
7426-7436
2015
hepatitis C virus genotype 1a, Hepatitis C virus subtype 3a, Hepatitis C virus genotype 4a (O39929), Hepatitis C virus genotype 5a (O91936), Hepatitis C virus genotype 2a (Q99IB8)
Manually annotated by BRENDA team
Yang, C.M.; Yoon, J.C.; Park, J.H.; Lee, J.M.
Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3
PLoS ONE
12
e0175793
2017
Hepatitis C virus genotype 2a (Q99IB8)
Manually annotated by BRENDA team