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Information on EC 3.4.21.60 - Scutelarin and Organism(s) Echis carinatus and UniProt Accession Q90495

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EC Tree
     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.60 Scutelarin
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This record set is specific for:
Echis carinatus
UNIPROT: Q90495 not found.
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Word Map
The taxonomic range for the selected organisms is: Echis carinatus
The enzyme appears in selected viruses and cellular organisms
Synonyms
ecarin, prothrombin activator, lopap, pseutarin c, cotiaractivase, cotiarinase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
prothrombin activator
-
Proteinase, Oxyuranus scutellatus prothrombin-activating
-
-
-
-
Taipan activator
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY hide
93389-45-8
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
prothrombin + H2O
?
show the reaction diagram
ecarin converts prothrombin to thrombin also if the prothrombin is not gamma-carboxylated
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
prothrombin + H2O
?
show the reaction diagram
ecarin converts prothrombin to thrombin also if the prothrombin is not gamma-carboxylated
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
-
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Zn2+
Zn-metalloprotease
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
apart from the natural activation pathway, human prothrombin can also be activated by prothrombin activators in snake venoms. Ecarin is not dependent on any cofactors, but generates meizothrombin
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
VM3E_ECHCA
616
0
69463
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Loevgren, A.
Recombinant snake venom prothrombin activators
Bioengineered
4
153-157
2013
Echis carinatus (Q90495), Echis carinatus
Manually annotated by BRENDA team