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Information on EC 3.4.21.38 - coagulation factor XIIa and Organism(s) Rattus norvegicus and UniProt Accession D3ZTE0

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     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.21 Serine endopeptidases
                3.4.21.38 coagulation factor XIIa
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Select one or more organisms in this record:
This record set is specific for:
Rattus norvegicus
UNIPROT: D3ZTE0 not found.
Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
selective cleavage of Arg-/-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa
Synonyms
activated factor XII, alpha-FXIIa, beta-FXIIa, blood coagulation factor XII, blood-coagulation factor XII, activated beta, blood-coagulation factor XIIabeta, blood-coagulation factor XIIf, coagulation beta-factor XIIa, coagulation factor XII, coagulation factor XIIa, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
beta-FXIIa
blood-coagulation factor XII, activated beta
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blood-coagulation factor XIIabeta
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blood-coagulation factor XIIf
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coagulation factor XIIa
283332
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factor XII
248
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HAF
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Hageman factor
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Hageman factor beta-fragment
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Hageman factor fragment HFf
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Hagemann factor
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kallikreinogen, activator
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prealbumin activator
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prekallikrein activator
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CAS REGISTRY NUMBER
COMMENTARY hide
75216-42-1
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
factor XI + H2O
factor XIa
show the reaction diagram
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?
prekallikrein + H2O
kallikrein + kallikrein prepeptide
show the reaction diagram
additional information
?
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blood pressure and heart rate estimated in bioassay rats after intravenous bolus of the activated beta-fragment of human coagulation factor XIIa
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
prekallikrein + H2O
kallikrein + kallikrein prepeptide
show the reaction diagram
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?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Ir-CPI
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the recombinant Ixodes ricinus contact phase inhibitor, a Kunitz-type protein expressed by the salivary glands of the tick Ixodes ricinus, Ir-CPI inhibits the activation of contact system factors, and it prolongs the activated partial thromboplastin time in vitro. Effects of Ir-CPI in vivo are determined using both venous and arterial thrombosis models, overview. the effective antithrombotic dose of Ir-CPI did not promote bleeding or impair blood coagulation parameters
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
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as with heparin, sulfated galactan from Gelidium crinale does not activate factor XII, while the polysaccharide from Botryocladia accidentalis activates factor XII in high concentrations
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
blood pressure and heart rate response to activated beta-form of human coagulation factor XIIa determined in bioassay rats, eliciting effects on plasma epinephrine and norepinephrine indicated, response to bradykinin tested, kininogen-deficient BNK strains and adrenal medullectomized rats included
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
coagulation factor XII precursor; Brown Norway strain, male rats injected with the activated beta-fragment of human beta-FXIIa
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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cultured in serum-free medium
Manually annotated by BRENDA team
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major site of factor XII synthesis
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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beta-FXIIa infusion into neurally intact, non-medicated, Brown Norway rats elicits a significant vasoconstrictor response
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
FA12_RAT
595
0
65844
Swiss-Prot
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30000
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x * 30000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
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x * 30000, SDS-PAGE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
influence of blood coagulation factors on blood pressure analyzed, blood pressure and heart rate of bioassay rats studied after intravenous bolus of the activated beta-fragment of human coagulation factor XIIa
drug development
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a contact phase inhibitor of FXIIa is an effective and safe antithrombotic agent in vivo
medicine
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folate-deficiency induced hyperhomocysteinemia reduces the functional activities of factors XII, X, and II. Folic acid supplementations restores
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gordon, E.M.; Johnson, T.R.; Ramos, L.P.; Schmeidler-Sapiro, K.T.
Enhanced expression of factor XII (Hageman factor) in isolated livers of estrogen- and prolacton-treated rats
J. Lab. Clin. Med.
117
353-358
1991
Rattus norvegicus
Manually annotated by BRENDA team
Gordon, E.M.; Gallagher, C.A.; Johnson, T.R.; Blossey, B.K.; Ilan, J.
Hepatocytes express blood coagulation factor XII (Hageman factor)
J. Lab. Clin. Med.
115
463-469
1990
Rattus norvegicus
Manually annotated by BRENDA team
Ebbesen, L.S.; Ingerslev, J.
Folate deficiency-induced hyperhomocysteinemia attenuates, and folic acid supplementation restores, the functional activities of rat coagulation factors XII, X, and II
J. Nutr.
135
1836-1840
2005
Rattus norvegicus
Manually annotated by BRENDA team
Amfilochiadis, A.A.; Backx, P.H.; Floras, J.S.
Adrenomedullary catecholamine, pressor and chronotropic responses to human coagulation beta-FXIIa mediated by endogenous kinins
J. Hypertens.
26
61-69
2008
Rattus norvegicus (D3ZTE0)
Manually annotated by BRENDA team
Fonseca, R.J.; Oliveira, S.N.; Melo, F.R.; Pereira, M.G.; Benevides, N.M.; Mourao, P.A.
Slight differences in sulfation of algal galactans account for differences in their anticoagulant and venous antithrombotic activities
Thromb. Haemost.
99
539-545
2008
Rattus norvegicus
Manually annotated by BRENDA team
Decrem, Y.; Rath, G.; Blasioli, V.; Cauchie, P.; Robert, S.; Beaufays, J.; Frere, J.M.; Feron, O.; Dogne, J.M.; Dessy, C.; Vanhamme, L.; Godfroid, E.
Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis
J. Exp. Med.
206
2381-2395
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Manually annotated by BRENDA team
Papageorgiou, P.C.; Yeo, E.L.; Backx, P.H.; Floras, J.S.
Activated plasma coagulation beta-factor XII-induced vasoconstriction in rats
Clin. Sci.
122
581-590
2012
Rattus norvegicus
Manually annotated by BRENDA team
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