Disease on EC 3.4.17.23 - angiotensin-converting enzyme 2

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Acute Coronary Syndrome
Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort.
Acute Kidney Injury
Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression.
Acute Lung Injury
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
ACE2 Antagonizes VEGFa to Reduce Vascular Permeability During Acute Lung Injury.
Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats.
Angiotensin-(1-7) Protects From Experimental Acute Lung Injury.
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury.
Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing MiR-4262.
Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing SMAD2 Phosphorylation.
Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-?B signaling pathways.
Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK/mTOR signaling.
Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation.
Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice.
Crosstalk between ACE2 and PLGF regulates vascular permeability during acute lung injury.
Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus.
Mesenchymal stem cell-based angiotensin-converting enzyme 2 in treatment of acute lung injury rat induced by bleomycin.
microRNA-1246 mediates lipopolysaccharide-induced pulmonary endothelial cell apoptosis and acute lung injury by targeting angiotensin-converting enzyme 2.
Molecular and cellular mechanisms of the inhibitory effects of ACE-2/ANG1-7/Mas axis on lung injury.
MSCs with ACE II gene affect apoptosis pathway of acute lung injury induced by bleomycin.
Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.
Osthole protects lipopolysaccharide-induced acute lung injury in mice by preventing down-regulation of angiotensin-converting enzyme 2.
Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.
The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice.
[ACE2 agonist DIZE alleviates lung injury induced by limb ischemia-reperfusion in mice].
[Effect of endotoxin on expression of angiotensin converting enzyme-2 in cultured rat pulmonary microvascular endothelial cells.]
Adenocarcinoma
Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression.
Adenocarcinoma of Lung
Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma.
Albuminuria
Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice.
Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes.
Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
Alzheimer Disease
Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-? and tau pathology.
Anemia
Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.
Anemia, Sickle Cell
Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.
Aneurysm
Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm.
Aneurysm, Dissecting
Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm.
angiotensin-converting enzyme 2 deficiency
Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet.
Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.
Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction.
Aortic Aneurysm, Abdominal
Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2.
Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm.
Arthritis
Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
Arthritis, Experimental
Inflammation Alters Angiotensin Converting Enzymes (ACE and ACE-2) Balance in Rat Heart.
Asthma
Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model.
Atherosclerosis
Activation of the Renin-Angiotensin system mediates the effects of dietary salt intake on atherogenesis in the apolipoprotein E knockout mouse.
Angiotensin converting enzyme 2 and atherosclerosis.
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.
Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.
Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease.
Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease.
Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation.
Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice.
Hydrogen Sulfide Attenuates Atherosclerosis in a Partially Ligated Carotid Artery Mouse model via Regulating Angiotensin Converting Enzyme 2 Expression.
Immunolocalization of ACE2 and AT2 Receptors in Rabbit Atherosclerotic Plaques.
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease.
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.
Atrial Fibrillation
Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling.
Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation.
N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery.
Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients.
[Effects of angiotensin converting enzyme inhibitor on the expression of angiotensin converting enzyme 2 in atrium of patients with atrial fibrillation]
Bradycardia
Overexpression of AT2R in the solitary-vagal complex improves baroreflex in the spontaneously hypertensive rat.
Carcinoma, Hepatocellular
ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
Carcinoma, Non-Small-Cell Lung
ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition.
Association between Serum Angiotensin-converting Enzyme 2 Level with Postoperative Morbidity and Mortality after Major Pulmonary Resection in Non-small Cell Lung Cancer Patients.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer.
Cardiomegaly
Activation of the Cardiac Renin-Angiotensin System in High Oxygen-Exposed Newborn Rats: Angiotensin Receptor Blockade Prevents the Developmental Programming of Cardiac Dysfunction.
Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy.
Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice.
Inhibition of Angiotensin-Converting Enzyme 2 Exacerbates Cardiac Hypertrophy and Fibrosis in Ren-2 Hypertensive Rats.
Role of angiotensin-converting enzyme 2 in cardiac hypertrophy induced by nitric oxide synthase inhibition.
Cardiomyopathies
Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats.
Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system.
Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes.
Cardiomyopathy, Dilated
Olmesartan medoxomil treatment potently improves cardiac myosin-induced dilated cardiomyopathy via the modulation of ACE-2 and ANG 1-7 mas receptor.
Cardiomyopathy, Hypertrophic
Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy.
Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy.
Cardiovascular Diseases
ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis.
ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages.
ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity.
Angiotensin-converting enzyme 2 activation improves endothelial function.
Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia.
Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats.
Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats.
Cerebroprotection by angiotensin (1-7) in endothelin-1 induced ischemic stroke.
Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease.
Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease.
Insufficient hypothalamic angiotensin-converting enzyme 2 is associated with hypertension in SHR rats.
Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases.
Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 2.
Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats.
SHOX Duplication and Tall Stature in a Patient with Xq Deletion and Vascular Disease.
Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays.
Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.
Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.
Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases.
The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population.
Cerebral Amyloid Angiopathy
Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-? and tau pathology.
Cerebrovascular Disorders
The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population.
Connective Tissue Diseases
Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases.
Coronary Artery Disease
Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Coronary Disease
The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Coronavirus Infections
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2.
Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro.
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
Cysts
Functional characterisation of a cyst nematode acetylcholinesterase gene using Caenorhabditis elegans as a heterologous system.
Diabetes Mellitus
Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus.
RELATIONSHIP OF OXIDATIVE STRESS TO URINARY ANGIOTENSIN CONVERTING ENZYME 2 IN TYPE 2 DIABETES MELLITUS PATIENTS.
The influence of angiotensin converting enzyme-2 gene polymorphisms: what does it predict in patients with diabetes mellitus and coronary heart disease?
The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Diabetes Mellitus, Type 1
Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-?1-induced kidney injury in a mouse model of diabetes.
Diabetes Mellitus, Type 2
Erratum to: Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients.
Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
RELATIONSHIP OF OXIDATIVE STRESS TO URINARY ANGIOTENSIN CONVERTING ENZYME 2 IN TYPE 2 DIABETES MELLITUS PATIENTS.
The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease.
Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Diabetic Cardiomyopathies
Angiotensin 1-7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation.
Diabetic Nephropathies
A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.
ACE2 as therapy for glomerular disease: the devil is in the detail.
Advances in the renin-angiotensin-aldosterone system: relevance to diabetic nephropathy.
Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation and lipotoxicity.
Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy.
Angiotensin-Converting Enzyme 2 Overexpression Remarkably Ameliorated Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition.
Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy.
Assessment of diabetic nephropathy in the akita mouse.
Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.
Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
Olmesartan Blocks Advanced Glycation End Products-induced VCAM-1 Gene Expression in Mesangial Cells by Restoring Angiotensin-converting Enzyme 2 Level.
Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice.
Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus.
Urinary angiotensin-converting enzyme 2 increases in diabetic nephropathy by angiotensin II type 1 receptor blocker olmesartan.
[Association between angiotensin-converting enzyme 2 gene polymorphisms and childhood primary nephrotic syndrome].
Diabetic Retinopathy
Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.
Dyspnea
Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study.
Eclampsia
Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7).
Encephalitis, Japanese
Resolving genetic diversity in Australasian Culex mosquitoes: incongruence between the mitochondrial cytochrome c oxidase I and nuclear acetylcholine esterase 2.
Essential Hypertension
ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects.
Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7).
Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China.
Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: A case-control study.
Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha, India.
Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese.
Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects.
No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension.
Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites.
The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients.
[Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke.]
[Relationship of angiotensin-converting enzyme 2 gene polymorphism with the prognosis of hypertensive stroke patients]
Fatty Liver
Impact of hepatic immunoreactivity of angiotensin-converting enzyme 2 on liver fibrosis due to non-alcoholic steatohepatitis.
Pioglitazone upregulates hepatic angiotensin converting enzyme 2 expression in rats with steatohepatitis.
Fetal Growth Retardation
Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction.
Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.
Gallbladder Neoplasms
Loss of angiotensin-converting enzyme 2 promotes growth of gallbladder cancer.
Glaucoma
Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.
Ocular Inserts for Sustained Release of the Angiotensin-Converting Enzyme 2 Activator, Diminazene Aceturate, to Treat Glaucoma in Rats.
Glomerulonephritis, IGA
Glomerular angiotensin-converting enzyme 2 in pediatric IgA nephropathy.
Glucose Intolerance
Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet.
Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes.
Heart Diseases
Plasma and tissue angiotensin-converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
Heart Failure
Angiotensin (1-7) and other angiotensin peptide.
Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure.
Angiotensin-converting enzyme 2 as a therapeutic target for heart failure.
Angiotensin-converting enzyme 2 overexpression improves central nitric oxide-mediated sympathetic outflow in chronic heart failure.
Balance between angiotensin converting enzyme and angiotensin converting enzyme 2 in patients with chronic heart failure.
Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure.
Cardiac and renal distribution of ACE and ACE-2 in rats with heart failure.
Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution.
Commenting on "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues.
Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system.
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via G?q-mediated mechanism.
Increasing serum soluble Angiotensin-converting enzyme 2 activity after intensive medical therapy is associated with better prognosis in acute decompensated heart failure.
Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.
Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients.
N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery.
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure.
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study.
Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study.
Recombinant human Angiotensin-converting enzyme 2 as a new Renin-Angiotensin system peptidase for heart failure therapy.
Serum angiotensin-converting enzyme 2 concentration and angiotensin-(1-7) concentration in patients with acute heart failure patients requiring emergency hospitalization.
Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction.
Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes.
[Cloning of ACE-2 gene encoding the functional receptor for the SARS coronavirus and its expression in eukaryotic cells]
[Role of ACE2-Ang (1-7)-Mas receptor axis in heart failure with preserved ejection fraction with hypertension].
Heart Failure, Systolic
Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction.
Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes.
Hepatitis C
The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2.
Hyperglycemia
Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina.
Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
Hypertension
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.
ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury.
Administration of 17?-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism.
Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension.
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice.
Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice.
Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat.
Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort.
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels.
Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension.
Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension.
Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats.
Angiotensin-converting enzyme 2 is an essential regulator of heart function.
Angiotensin-converting enzyme 2: a new target for neurogenic hypertension.
Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease.
Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 are involved in sinoaortic denervation-induced cardiovascular hypertrophy in rats.
Antenatal maternal low protein diet: ACE-2 in the mouse lung and sexually dimorphic programming of hypertension.
Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome.
Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress.
Brain ACE2 Shedding Contributes to the Development of Neurogenic Hypertension.
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension.
Brain-targeted Angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation.
Chronic sleep restriction during pregnancy--repercussion on cardiovascular and renal functioning of male offspring.
Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.
Collectrin, an X-Linked, ACE2 Homologue Causes Hypertension in a Rat Strain through Gene-Gene and Gene-Environment Interactions: Relevance to Human Hypertension.
Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese.
Effect of Prolonged Infusion of Alamandine on Cardiovascular Parameters and Cardiac ACE2 Expression in a Rat Model of Renovascular Hypertension.
FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice.
Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension.
Insufficient hypothalamic angiotensin-converting enzyme 2 is associated with hypertension in SHR rats.
Loss of Collectrin, an ACE2 Homologue, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction.
Measuring Blood Pressure Using a Noninvasive Tail Cuff Method in Mice.
Multiple faces of fibroblast growth factor-23.
Murine Recombinant Angiotensin-Converting Enzyme 2: Effect on Angiotensin II-Dependent Hypertension and Distinctive Angiotensin-Converting Enzyme 2 Inhibitor Characteristics on Rodent and Human Angiotensin-Converting Enzyme 2.
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure.
Nicotine modulates the Renin-Angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of wistar kyoto and spontaneously hypertensive rats.
No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension.
Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats.
Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients.
Propofol increases angiotensin-converting enzyme 2 expression in human pulmonary artery endothelial cells.
Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17beta-oestradiol regulation of renal pathology in renal wrap hypertension in rats.
Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.
[An experimental study of expression of angiotension converting enzyme 2 in myocardium and effect of telmisartan treatment in pressure-overloaded rats]
[Association between angiotensin-converting enzyme 2 gene polymorphisms and childhood primary nephrotic syndrome].
[Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]
[Role of ACE2-Ang (1-7)-Mas receptor axis in heart failure with preserved ejection fraction with hypertension].
Hypertension, Portal
Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation.
Hypertension, Pulmonary
Angiotensin-converting enzyme 2 activation for treatment of pulmonary hypertension.
Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.
Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension.
MiRNA let-7b promotes the development of hypoxic pulmonary hypertension by targeting ACE2.
Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.
Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
Hypertension, Renovascular
Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension.
Hyperthyroidism
Cardiac ACE2/angiotensin 1-7/Mas receptor axis is activated in thyroid hormone-induced cardiac hypertrophy.
Hypertrophy, Left Ventricular
Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort.
Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men Results of the MONICA Augsburg echocardiographic substudy.
Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy.
Hypertension and hypertensive left ventricular hypertrophy are associated with ACE2 genetic polymorphism.
Multiple faces of fibroblast growth factor-23.
Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy.
Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients.
Hypotension
Intradialytic hypotension: beyond hemodynamics.
Idiopathic Pulmonary Fibrosis
Cell cycle-dependence of ACE-2 explains downregulation in Idiopathic pulmonary fibrosis.
Infections
Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus.
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.
Characterisation of animal angiotensin-converting enzyme 2 receptors and use of pseudotyped virus to correlate receptor binding with susceptibility of SARS-CoV infection.
Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease.
Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction.
Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2.
Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.
Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease.
Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2.
Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.
Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice.
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
Pathology and pathogenesis of severe acute respiratory syndrome.
Pathology of experimental SARS coronavirus infection in cats and ferrets.
Persistent infection of SARS coronavirus in colonic cells in vitro.
Reconstitution of the receptor-binding motif of the SARS coronavirus.
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs.
Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain.
Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.
Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections.
Susceptibility of different eukaryotic cell lines to SARS-coronavirus.
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
The emergence of human coronavirus EMC: how scared should we be?
Inflammatory Bowel Diseases
Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis.
Influenza in Birds
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.
Influenza, Human
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury.
Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus.
Insulin Resistance
Angiotensin Converting Enzyme 2 Activator DIZE Modulates Metabolic Profile in Mice Decreasing Lipogenesis.
Loss of ACE 2 Exaggerates High-Calorie Diet-Induced Insulin Resistance by Reduction of GLUT4 in Mice.
Keratosis, Actinic
ACE and ACE2 expression in normal and malignant skin lesions.
Kidney Diseases
ACE2 as therapy for glomerular disease: the devil is in the detail.
Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease.
Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
Kidney Failure, Chronic
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
Liver Cirrhosis
ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice.
Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis.
Impact of hepatic immunoreactivity of angiotensin-converting enzyme 2 on liver fibrosis due to non-alcoholic steatohepatitis.
The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice.
[Expression and correlation of angiotensin-converting enzyme 2 in CCl4-induced rat liver fibrosis].
Liver Diseases
Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.
Hepatic Fibrosis and the Renin-Angiotensin System.
Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis.
Lung Diseases
Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice.
Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients.
Angiotensin-converting enzyme 2 in lung diseases.
Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.
Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.
Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension.
Hyperoxia Downregulates Angiotensin Converting Enzyme-2 (ACE-2) in Human Fetal Lung Fibroblasts.
Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease.
Roles of the Angiotensin System in Neonatal Lung Injury and Disease.
Lung Injury
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury.
Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers.
Angiotensin-Converting Enzyme 2 Attenuates Bleomycin-Induced Lung Fibrosis in Mice.
Angiotensin-converting enzyme 2 attenuates inflammatory response and oxidative stress in hyperoxic lung injury by regulating NF-?B and Nrf2 pathways.
Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus.
Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation.
LPS-Stimulated Cytokine Production in Type I Cells is Modulated by the Renin-Angiotensin System.
Mesenchymal Stem Cells Overexpressing Angiotensin-Converting Enzyme 2 Rescue Lipopolysaccharide-Induced Lung Injury.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
Roles of the Angiotensin System in Neonatal Lung Injury and Disease.
[Protective Effect of Angiotensin Converting Enzyme 2 (ACE2) Against Chronic Intermittent Hypoxia-induced Pulmonary Oxidative Stress Injury in Rats].
Lung Neoplasms
ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition.
Association between Serum Angiotensin-converting Enzyme 2 Level with Postoperative Morbidity and Mortality after Major Pulmonary Resection in Non-small Cell Lung Cancer Patients.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer.
Malnutrition
Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant.
Meconium Aspiration Syndrome
Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome.
Metabolic Diseases
Angiotensin 1-7: A peptide for preventing and treating metabolic syndrome.
Metabolic Syndrome
Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome.
[Effect of Astragali Radix in improving early renal damage in metabolic syndrome rats through ACE2/Mas pathway].
Muscle Weakness
Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Myocardial Infarction
ACE2 Overexpression Improves Left Ventricular Remodeling and Function in Rats with Myocardial Infarction.
Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence.
Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting.
Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions.
Diminazene aceturate enhances Angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology.
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.
N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery.
Postconditioning attenuates coronary perivascular and interstitial fibrosis through modulating angiotensin II receptors and angiotensin-converting enzyme 2 after myocardial infarction.
Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: a prospective controlled study.
The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats.
Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors.
Neoplasm Metastasis
Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition.
Neoplasms
Angiotensin-(1-7) Attenuates Kidney Injury Due to Obstructive Nephropathy in Rats.
Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression.
Expression of renin-angiotensin system (RAS) components in endometrial cancer.
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
Selective and Specific Regulation of Ectodomain Shedding of Angiotensin-converting Enzyme 2 by Tumor Necrosis Factor {alpha}-converting Enzyme.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer.
The association of renin-angiotensin system genes with the progression of hepatocellular carcinoma.
Underlying mechanisms behind the protective effect of angiotensin (1-7) in experimental rat model of ovarian ischemia reperfusion injury.
Nephritis, Hereditary
ACE2 as therapy for glomerular disease: the devil is in the detail.
Nephrotic Syndrome
Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome.
Neuralgia
The Implications of Angiotensin-Converting Enzymes and Their Modulators in Neurodegenerative Disorders: Current and Future Perspectives.
Non-alcoholic Fatty Liver Disease
Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.
Pioglitazone upregulates angiotensin converting enzyme 2 expression in insulin-sensitive tissues in rats with high-fat diet-induced nonalcoholic steatohepatitis.
Obesity
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice.
Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
Pancreatic Neoplasms
Angiotensin-converting enzyme 2 acts as a potential molecular target for pancreatic cancer therapy.
Pneumonia
Impact of angiotensin-converting enzyme 2 levels on postoperative pneumonia after esophagectomy.
Post-Exercise Hypotension
Angiotensin converting enzyme 2 polymorphisms and postexercise hypotension in hypertensive medicated individuals.
Postural Orthostatic Tachycardia Syndrome
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome.
Proteinuria
ACE2 as therapy for glomerular disease: the devil is in the detail.
Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome.
Pulmonary Arterial Hypertension
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels.
Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension.
Propofol increases angiotensin-converting enzyme 2 expression in human pulmonary artery endothelial cells.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
Pulmonary Disease, Chronic Obstructive
Angiotensin-converting enzyme-2 overexpression attenuates inflammation in rat model of chronic obstructive pulmonary disease.
Commenting on "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues.
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study.
Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study.
Pulmonary Embolism
RhoA-Rho associated kinase signaling leads to renin-angiotensin system imbalance and angiotensin converting enzyme 2 has a protective role in acute pulmonary embolism.
Pulmonary Fibrosis
Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension.
Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.
The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway.
The renin angiotensin system in liver and lung: impact and therapeutic potential in organ fibrosis.
Renal Insufficiency, Chronic
Angiotensin-converting enzyme 2 activity in patients with chronic kidney disease.
Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease.
Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease.
Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease.
Intrarenal Distributions and Changes of Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 in Feline and Canine Chronic Kidney Disease.
Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury.
Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease.
Reperfusion Injury
Combination therapy with human umbilical cord mesenchymal stem cells and angiotensin-converting enzyme 2 is superior for the treatment of acute lung ischemia-reperfusion injury in rats.
The functional study of human umbilical cord mesenchymal stem cells harbouring angiotensin-converting enzyme 2 in rat acute lung ischemia-reperfusion injury model.
[Angiotensin-converting enzyme 2 gene transfer attenuates neointimal formation after carotid artery ischemia-reperfusion injury in rats].
Respiratory Distress Syndrome, Adult
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
Angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
Imbalance between pulmonary angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in acute respiratory distress syndrome.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
[Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]
Respiratory Insufficiency
Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry.
Sarcoidosis
Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients.
Severe Acute Respiratory Syndrome
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.
Amino acid substitutions in the s2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells.
Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.
Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints.
Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion.
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.
Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin.
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2.
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2.
Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.
Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2).
Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors.
Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.
Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro.
Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction.
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis.
Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63.
Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2.
Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques.
SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.
SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).
Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
Severe acute respiratory syndrome: an update.
Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody.
Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
The emergence of human coronavirus EMC: how scared should we be?
The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2.
Vesicular stomatitis virus pseudotyped with severe acute respiratory syndrome coronavirus spike protein.
[Cloning of ACE-2 gene encoding the functional receptor for the SARS coronavirus and its expression in eukaryotic cells]
[Expression of severe acute respiratory syndrome coronavirus receptors, ACE2 and CD209L in different organ derived microvascular endothelial cells]
Stroke
Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke.
Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion.
Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats.
Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.
Stages in Discovery: Angiotensin-Converting Enzyme Type 2 and Stroke.
[Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke.]
[Relationship of angiotensin-converting enzyme 2 gene polymorphism with the prognosis of hypertensive stroke patients]
Tachycardia
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome.
Thrombosis
The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases.
Trypanosomiasis
Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
Ureteral Obstruction
Altered regulation of renin-angiotensin, endothelin and natriuretic peptide systems in rat kidney with chronic unilateral ureteral obstruction.
Uveitis
AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-?B and STAT3 Pathways.
Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.
Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis.
Vascular Diseases
rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling.
Ventricular Dysfunction
Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat.
Virus Diseases
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2.
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs.