Information on EC 3.4.13.4 - Xaa-Arg dipeptidase

for references in articles please use BRENDA:EC3.4.13.4
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The enzyme appears in viruses and cellular organisms

top print hide
EC NUMBER
COMMENTARY hide
3.4.13.4
-
top print hide
RECOMMENDED NAME
GeneOntology No.
Xaa-Arg dipeptidase
-
top print hide
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
preferential hydrolysis of Xaa-/-Arg, Xaa-/-Lys or Xaa-/-ornithine dipeptides
show the reaction diagram
-
-
-
-
top print hide
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of peptide bond
-
-
dipeptide hydrolysis
-
top print hide
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
beta-Alanine metabolism
-
-
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top print hide
CAS REGISTRY NUMBER
COMMENTARY hide
37288-72-5
-
top print hide
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
top print hide
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
aminoacyl-L-arginine + H2O
L-arginine + acylamine
show the reaction diagram
-
-
-
ir
aminoacyl-L-lysine + H2O
?
show the reaction diagram
-
-
-
-
-
aminoacyl-L-lysine + H2O
L-lysine + acylamine
show the reaction diagram
-
-
-
-
ir
aminoacyl-L-ornithine + H2O
L-ornithine + acylamine
show the reaction diagram
-
-
-
ir
Nalpha-(gamma-aminobutryryl)-Arg + H2O
aminobutyrate + Arg
show the reaction diagram
-
-
-
-
?
Nalpha-(gamma-aminobutryryl)-Lys + H2O
aminobutyrate + Lys
show the reaction diagram
additional information
?
-
-
no hydrolysis of: Nepsilon-(gamma-aminobutyryl)-Lys, dipeptides in which the N-alpha-amino group is blocked, dipeptides in which the C-terminus is blocked
-
-
-
top print hide
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aminoacyl-L-lysine + H2O
?
show the reaction diagram
-
-
-
-
-
top print hide
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Ca2+
-
activation
Mg2+
-
activation
Mn2+
-
activation
top print hide
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
-
-
aliphatic amino acids
-
-
Cd2+
-
-
Cu2+
-
-
Hg2+
-
-
p-chloromercuribenzoate
-
-
phosphate
-
-
Zn2+
-
-
top print hide
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
9.8
N2-(4-aminobutyryl)-L-lysine
-
-
top print hide
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.8
-
-
top print hide
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.1 - 6.8
-
N2-(4-aminobutyryl)-L-lysine
top print hide
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
top print hide
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
4°C, 1 week
-
top print hide
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 3.4.13.4)
ExplorEnz
ExPASy
KEGG
MetaCyc
SABIO-RK
NCBI: PubMed, Protein, Nucleotide, Structure, Genome, OMIM
IUBMB Enzyme Nomenclature
PROSITE Database of protein families and domains
InterPro (database of protein families, domains and functional sites)