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EC Tree
The enzyme appears in viruses and cellular organisms
Reaction Schemes
preferential hydrolysis of Xaa-/-Arg, Xaa-/-Lys or Xaa-/-ornithine dipeptides
Synonyms
aminoacyl-lysine dipeptidase, aminoacyllysine dipeptidase, N2-(4-amino-butyryl)-L-lysine hydrolase, Nalpha-(gamma-aminobutyryl)-lysine hydrolase,
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aminoacyl-lysine dipeptidase
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aminoacyllysine dipeptidase
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N2-(4-amino-butyryl)-L-lysine hydrolase
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Nalpha-(gamma-aminobutyryl)-lysine hydrolase
Nalpha-(gamma-aminobutyryl)-lysine hydrolase
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Nalpha-(gamma-aminobutyryl)-lysine hydrolase
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Nalpha-(gamma-aminobutyryl)-lysine hydrolase
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preferential hydrolysis of Xaa-/-Arg, Xaa-/-Lys or Xaa-/-ornithine dipeptides
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hydrolysis of peptide bond
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dipeptide hydrolysis
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aminoacyl-L-arginine + H2O
L-arginine + acylamine
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aminoacyl-L-lysine + H2O
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aminoacyl-L-lysine + H2O
L-lysine + acylamine
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aminoacyl-L-ornithine + H2O
L-ornithine + acylamine
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Nalpha-(gamma-aminobutryryl)-Arg + H2O
4-aminobutyrate + Arg
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Nalpha-(gamma-aminobutryryl)-Lys + H2O
4-aminobutyrate + Lys
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additional information
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no hydrolysis of: Nepsilon-(gamma-aminobutyryl)-Lys, dipeptides in which the N-alpha-amino group is blocked, dipeptides in which the C-terminus is blocked
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aminoacyl-L-lysine + H2O
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aliphatic amino acids
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p-chloromercuribenzoate
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9.8
N2-(4-aminobutyryl)-L-lysine
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6.1 - 6.8
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N2-(4-aminobutyryl)-L-lysine
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Kumon, A.; Matsuoka, Y.; Nakajima, T.; Sano, I.
A peptidase that hydrolyzes N alpha (gamma-aminobutyryl)lysine
Biochim. Biophys. Acta
200
466-474
1976
Sus scrofa
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Wilk, S.
X-Arg dipeptidase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
1
1017-1018
2004
Oryctolagus cuniculus, Rattus norvegicus, Sus scrofa
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3.4.13.4 Xaa-Arg dipeptidase
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