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The enzyme appears in viruses and cellular organisms
Reaction Schemes
hydrolysis of dipeptides containing either D- or L-amino acids or both
Synonyms
D-(or L-)aminoacyl dipeptidase, peptidy-D-amino acid hydrolase,
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D-(or L-)aminoacyl dipeptidase
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peptidy-D-amino acid hydrolase
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hydrolysis of dipeptides containing either D- or L-amino acids or both
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hydrolysis of peptide bond
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D-Ala-D-Ala + H2O
D-Ala + D-Ala
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3-20% hydrolysis, depending on reaction time
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D-Ala-Gly + H2O
D-Ala + Gly
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15-100% hydrolysis, depending on reaction time
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D-Ala-L-Ala + H2O
D-Ala + L-Ala
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1-10% hydrolysis, depending on reaction time
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D-amino acid peptide + H2O
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D-Leu-D-Leu + H2O
D-Leu + D-Leu
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75-100% hydrolysis, depending on reaction time
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D-Leu-Gly-Gly + H2O
D-Leu + Gly-Gly
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30-100% hydrolysis, depending on reaction time
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D-Leu-Leu + H2O
D-Leu + Leu
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70-100% hydrolysis, depending on reaction time
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Gly-D-Ala + H2O
Gly + D-Ala
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80-100% hydrolysis, depending on reaction time
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Gly-D-Asp + H2O
Gly + D-Asp
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30-100% hydrolysis, depending on reaction time
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Gly-D-Leu + H2O
Gly + D-Leu
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90-100% hydrolysis, depending on reaction time
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Gly-D-Phe + H2O
Gly + D-Phe
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10-50% hydrolysis, depending on reaction time
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Gly-D-Ser + H2O
Gly + D-Ser
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30-100% hydrolysis, depending on reaction time
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Gly-Gly-D-Leu + H2O
Gly-Gly + D-Leu
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2-20% hydrolysis, depending on reaction time
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Gly-L-Ala + H2O
Gly + L-Ala
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L-Ala-D-Ala + H2O
L-Ala + Ala
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100% hydrolysis
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L-Ala-L-Ala + H2O
L-Ala + L-Ala
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L-Leu-D-Leu + H2O
Leu + D-Leu
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2-15% hydrolysis, depending on reaction time
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L-Leu-L-Leu + H2O
L-Leu + L-Leu
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L-Tyr-D-Ala-Gly-L-Phe-L-Met-NH2 + H2O
L-Tyr + D-Ala-Gly-L-Phe-L-Met-NH2
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4-40% hydrolysis, depending on reaction time
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L-Tyr-D-Arg + H2O
L-Tyr + D-Arg
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2-20% hydrolysis, depending on reaction time
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additional information
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also hydrolysis of L-peptides and enkephalins, no hydrolysis of peptides with substituted amino-terminus
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D-amino acid peptide + H2O
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involved in breakdown of D-amino acid peptides which are present in nervous system of cephalopods
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D-amino acid peptide + H2O
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involved in breakdown of D-amino acid peptides which are present in nervous system of cephalopods
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D-amino acid peptide + H2O
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involved in breakdown of D-amino acid peptides which are present in nervous system of cephalopods
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D-amino acid peptide + H2O
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D-amino acid peptide + H2O
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involved in breakdown of D-amino acid peptides which are present in nervous system of cephalopods
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D-amino acid peptide + H2O
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involved in breakdown of D-amino acid peptides which are present in nervous system of cephalopods
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D-amino acid peptide + H2O
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involved in breakdown of D-amino acid peptides which are present in nervous system of cephalopods
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CaCl2
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50 mM, 5-10% inhibition, no inhibition up to 1 mM
CdCl2
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50 mM, 5-10% inhibition, no inhibition up to 1 mM
Pb(CH3COO)2
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50 mM, 5-10% inhibition, no inhibition up to 1 mM
additional information
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not inhibitory are 1 mM of MnCl2, MgCl2, ZnCl2, CuCl2 or 100 mM of NaCl, KCl, Na2SO4 or 50 mM of EDTA, guanidine chloride or 3 M of urea
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23.3
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substrate Gly-D-Ala
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highest activity in digestive juice
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cecum
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cecum
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cecum
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posterior
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posterior
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posterior
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106000
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1 * 106000 + 1 * 34000, SDS-PAGE
34000
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1 * 106000 + 1 * 34000, SDS-PAGE
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dimer
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1 * 106000 + 1 * 34000, SDS-PAGE
additional information
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amino acid analysis: high contributions of Asp, Glu, Gly, Val
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20
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pH 8.0, stable for 5 days
50
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pH 8.0, 5 min, 50% loss of activity
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-20°C, 0.05 M phosphate buffer, pH 7.0, 50% glycerol, 6 months, little loss of activity
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analysis
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improved method for hydrolyzing proteins and peptides without inducing racemization and for determining their true D-amino acid content
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D'Aniello, A.; Strazullo, L.
Peptidyl-D-amino acid hydrolase from Loligo vulgaris Lam. Purification and characterization
J. Biol. Chem.
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4237-4243
1984
Loligo vulgaris, Octopus vulgaris, Sepia officinalis
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D'Aniello, A.; Petrucelli, L.; Gardner, C.; Fisher, G.
Improved method for hydrolyzing proteins and peptides without inducing racemization and for determining their true D-amino acid content
Anal. Biochem.
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290-295
1993
Loligo vulgaris
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Woessner, J.F.
Met-X dipeptidase
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
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1018-1020
2004
Loligo vulgaris, Octopus vulgaris
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3.4.13.17 non-stereospecific dipeptidase
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