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Information on EC 3.2.2.28 - double-stranded uracil-DNA glycosylase

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EC Tree
     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.28 double-stranded uracil-DNA glycosylase
IUBMB Comments
No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue , significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing E. coli . Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC 3.2.2.27) and EC 3.2.2.28 form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA.
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Word Map
  • 3.2.2.28
  • dermatan
  • ehlers-danlos
  • musculocontractural
  • sulfotransferase
  • chst14
  • chondroitin
  • hyperextensibility
  • contractures
  • hematomas
  • 4-o-sulfotransferase-1
  • thymine
  • craniofacial
  • thumb-clubfoot
  • bruisable
  • decorin
  • kyphoscoliosis
  • thymine-dna
  • mispairs
  • 3,n4-ethenocytosine
  • thumb
  • bruisability
  • n2,3-ethenoguanine
  • laxity
  • talipes
  • etheno
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil
Synonyms
dsudg, double-strand uracil-dna glycosylase, g:t/u mismatch-specific dna glycosylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Specifically hydrolyses mismatched double-stranded DNA and polynucleotides, releasing free uracil
show the reaction diagram
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