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Information on EC 3.2.2.22 - rRNA N-glycosylase and Organism(s) Corynephage beta and UniProt Accession P00588

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EC Tree
     3 Hydrolases
         3.2 Glycosylases
             3.2.2 Hydrolysing N-glycosyl compounds
                3.2.2.22 rRNA N-glycosylase
IUBMB Comments
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.
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This record set is specific for:
Corynephage beta
UNIPROT: P00588
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Word Map
The taxonomic range for the selected organisms is: Corynephage beta
The enzyme appears in selected viruses and cellular organisms
Synonyms
pd-l1, ricin, shiga toxin, saporin, abrin, ricinus communis agglutinin, gelonin, ricin a chain, trichosanthin, ribosome-inactivating proteins, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
diphtheria toxin
-
gelonin
-
-
-
-
Mirabilis antiviral protein
-
-
-
-
momorcochin-S
-
-
-
-
nigrin b
-
-
-
-
ribosomal ribonucleate N-glycosidase
-
-
-
-
ricin
-
-
-
-
RNA N-glycosidase
-
-
-
-
rRNA N-glycosidase
-
-
-
-
saporins
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of N-glycosyl bond
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
rRNA N-glycohydrolase
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.
CAS REGISTRY NUMBER
COMMENTARY hide
113756-12-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
DTX_CORBE
567
1
61602
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kurnikov, I.V.; Kyrychenko, A.; Flores-Canales, J.C.; Rodnin, M.V.; Simakov, N.; Vargas-Uribe, M.; Posokhov, Y.O.; Kurnikova, M.; Ladokhin, A.S.
pH-triggered conformational switching of the diphtheria toxin T-domain: the roles of N-terminal histidines
J. Mol. Biol.
425
2752-2764
2013
Corynephage beta (P00588)
Manually annotated by BRENDA team