Information on EC - endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase

for references in articles please use BRENDA:EC3.2.1.210
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IUBMB Comments
In yeast this activity is catalysed by a dedicated enzyme that processes unfolded protein-bound Man8GlcNAc2 N-glycans within the endoplasmic reticulum to Man7GlcNAc2. The exposed alpha-1,6-linked mannose residue in the product enables the recognition by the YOS9 lectin, targeting the proteins for degradation. In mammalian cells this activity is part of the regular processing of N-glycosylated proteins, and is not associated with protein degradation. It is carried out by EC, Golgi mannosyl-oligosaccharide 1,2-alpha-mannosidase. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al .
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The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae
alpha-1,2-specific exomannosidase, alpha1,2-specific exomannosidase, EDEM, endoplasmic reticulum mannosidase-like protein, ERAD-related alpha-mannosidase, Htm1, Htm1 protein, Htm1p, mannosidase I-like protein, MNL1, more
Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + H2O = Man7GlcNAc2-[protein] (isomer 7A1,2,3B3) + -D-mannopyranose
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