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Information on EC 3.2.1.210 - endoplasmic reticulum Man8GlcNAc2 1,2-alpha-mannosidase

for references in articles please use BRENDA:EC3.2.1.210

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IUBMB Comments

In yeast this activity is catalysed by a dedicated enzyme that processes unfolded protein-bound Man8GlcNAc2 N-glycans within the endoplasmic reticulum to Man7GlcNAc2. The exposed α-1,6-linked mannose residue in the product enables the recognition by the YOS9 lectin, targeting the proteins for degradation. In mammalian cells this activity is part of the regular processing of N-glycosylated proteins, and is not associated with protein degradation. It is carried out by EC 3.2.1.113, Golgi mannosyl-oligosaccharide 1,2-α-mannosidase. The names of the isomers listed here are based on a nomenclature system proposed by Prien et al .

The expected taxonomic range for this enzyme is: Saccharomyces cerevisiae

Synonyms
htm1p, mnl1p, alpha1,2-specific exomannosidase, htm1 protein, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Man8GlcNAc2-[protein] (isomer 8A1,2,3B1,3) + H2O = Man7GlcNAc2-[protein] (isomer 7A1,2,3B3) + beta-D-mannopyranose
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
protein N-glycosylation processing phase (plants and animals)
Highest Expressing Human Cell Lines
Cell Line Links Gene Links