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Information on EC 3.2.1.184 - UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)

for references in articles please use BRENDA:EC3.2.1.184
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IUBMB Comments
Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose, which rapidly mutarotates to a mixture of anomers . The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine .
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The enzyme appears in viruses and cellular organisms
Synonyms
Cj1328, LeG, neuC, UDP-Bac2Ac4Ac 2-epimerase, UDP-N-acetylglucosamine 2-epimerase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N,N'-diacetylbacillosamine + H2O = UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose
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