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Information on EC 3.1.8.1 - aryldialkylphosphatase
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3.1.8.1 aryldialkylphosphataseIUBMB Comments
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
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Word Map
- 3.1.8.1
- arylesterase
- paraoxonase-1
- cholesterol
- nerve
- atherosclerosis
- cardiovascular
-
low-density
-
insecticide
- triglyceride
- coronary
-
apolipoproteins
- acetylcholinesterase
- malondialdehyde
- diminuta
-
poison
- soman
- p-nitrophenol
-
warfare
- sarin
-
bioremediation
- chlorpyrifos
- vx
-
antiatherogenic
-
decontamination
-
bioscavenger
- atherogenesis
- cholinesterase
- phenylacetate
- medicine
-
binuclear
-
phosphotriesters
-
atherogenic
- flavobacterium
- carboxylesterase
-
hdl-cholesterol
- apoa-i
- butyrylcholinesterase
- fluorophosphate
-
surface-expressed
- diazoxon
- tabun
-
thiolactone
-
g-type
-
salt-stimulated
-
triesters
- malathion
- ochrobactrum
- sphingobium
- radiobacter
- cyclosarin
-
loligo
- synthesis
- environmental protection
- drug development
- degradation
- biotechnology
- diagnostics
- agriculture
- analysis
- nutrition
The enzyme appears in viruses and cellular organisms
Synonyms
pon-1, serum paraoxonase, phosphotriesterase, organophosphorus hydrolase, dfpase, serum paraoxonase 1, pon 1, methyl parathion hydrolase, organophosphate hydrolase, hupon1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A-esterase
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-
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aryltriphosphatase
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-
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esterase B1
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-
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esterase E4
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-
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esterase, organophosphate
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-
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esterase, paraoxon
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esterase, pirimiphos-methyloxon
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-
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HuPON1
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-
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OPA anhydrase
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-
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OPH
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-
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organophosphate hydrolase
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-
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organophosphorus acid anhydrase
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organophosphorus hydrolase
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paraoxon hydrolase
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-
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paraoxonase
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phosphotriesterase
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pirimiphos-methyloxon esterase
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-
-
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PTE
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of phosphoric triester
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-
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-
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -
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SYSTEMATIC NAME
IUBMB Comments
aryltriphosphate dialkylphosphohydrolase
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
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CAS REGISTRY NUMBER
COMMENTARY
117698-12-1
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
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-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
diethyl-paraoxon + H2O
diethyl phosphate + 4-nitrophenol
-
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
architecture of active pocket of enzyme mPHP coordinates with two metal ions
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acromegaly
Serum paraoxonase level and paraoxonase polymorphism in patients with acromegaly.
Acute Coronary Syndrome
Association between serum paraoxonase activity and oxidative stress in acute coronary syndromes.
Acute Coronary Syndrome
Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk.
Acute Coronary Syndrome
Influence of high-density lipoprotein and paraoxonase-1 on platelet reactivity in patients with acute coronary syndromes receiving clopidogrel therapy.
Acute Coronary Syndrome
Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes.
Adrenocortical Hyperfunction
Serum paraoxonase 1 and butyrylcholinesterase in dogs with hyperadrenocorticism.
Alopecia Areata
Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata.
Alopecia Areata
Serum paraoxonase activity and oxidative status in subjects with alopecia areata.
Alzheimer Disease
Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases.
Alzheimer Disease
Lack of association between Alzheimer's disease and Gln-Arg 192 Q/R polymorphism of the PON-1 gene in an Italian population.
Alzheimer Disease
PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia.
Alzheimer Disease
Responsiveness to cholinesterase inhibitors in Alzheimer's disease: a possible role for the 192 Q/R polymorphism of the PON-1 gene.
Alzheimer Disease
Serum paraoxonase activity changes in patients with Alzheimer's disease and vascular dementia.
Alzheimer Disease
Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.
Alzheimer Disease
Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study.
Anemia
Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
Anemia
Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis.
Anemia
Paraoxonase and arylesterase activities in children with iron deficiency anemia and vitamin B12 deficiency anemia.
Anemia, Iron-Deficiency
Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
Anemia, Iron-Deficiency
Paraoxonase and arylesterase activities in children with iron deficiency anemia and vitamin B12 deficiency anemia.
Anemia, Iron-Deficiency
Serum paraoxonase 1 activity in patients with iron deficiency anemia.
Anemia, Sickle Cell
Paraoxonases (PON) 1, 2, and 3 Polymorphisms and PON-1 Activities in Patients with Sickle Cell Disease.
Angina Pectoris
Pro-inflammatory Mediators and Oxidative Stress: Therapeutic Markers for Recurrent Angina Pectoris after Coronary Artery Stenting in Elderly Patients.
Angina, Unstable
Gender-specific correlation between plasma myeloperoxidase levels and serum high-density lipoprotein-associated paraoxonase-1 levels in patients with stable and unstable coronary artery disease.
Anthrax
Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax.
Aortic Aneurysm, Abdominal
Identification of novel diagnostic and prognostic biomarkers for abdominal aortic aneurysm.
Arthritis
Suppression of inflammatory arthritis in human serum paraoxonase 1 transgenic mice.
Arthritis, Psoriatic
HDL associated paraoxonase-1 activity correlates with systemic inflammation, disease activity and cardiovascular risk factors in psoriatic disease.
Arthritis, Rheumatoid
Effect of Fish Oil Supplements on Serum Paraoxonase Activity in Female Patients with Rheumatoid Arthritis: A Double-blind Randomized Controlled Trial.
Arthritis, Rheumatoid
PON-1 haplotype (-108C>T, L55M, and Q192R) modulates the serum levels and activity PONase promoting an atherogenic lipid profile in rheumatoid arthritis patients.
Arthritis, Rheumatoid
Soy protein, genistein, and daidzein improve serum paraoxonase activity and lipid profiles in rheumatoid arthritis in rats.
aryldialkylphosphatase deficiency
Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.
aryldialkylphosphatase deficiency
Paraoxonase-2 deficiency enhances Pseudomonas aeruginosa quorum sensing in murine tracheal epithelia.
Asthma
Evaluation of serum paraoxonase and arylesterase activities in subjects with asthma and chronic obstructive lung disease.
Asthma
Relationship of Oxidant and Antioxidant Markers to Asthma Severity in Egyptian Asthmatic Children.
Asthma
[Serum paraoxonase activity, total antioxidant potential and lipid peroxidation products in children with bronchial asthma exacerbation]
Atherosclerosis
Adenovirus-mediated expression of human paraoxonase 3 protects against the progression of atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis
Ameliorative effect of statin therapy on oxidative damage in heart tissue of hypercholesterolemic rabbits.
Atherosclerosis
Antioxidant effect of atorvastatin is independent of PON1 gene T(-107)C, Q192R and L55M polymorphisms in hypercholesterolaemic patients.
Atherosclerosis
Association between human paraoxonase 1 activity and intima-media thickness in subjects under 55 years of age with carotid artery disease.
Atherosclerosis
Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients.
Atherosclerosis
Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells.
Atherosclerosis
Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis.
Atherosclerosis
Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk.
Atherosclerosis
Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis.
Atherosclerosis
Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice.
Atherosclerosis
Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice.
Atherosclerosis
Decreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis.
Atherosclerosis
Effect of levothyroxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism.
Atherosclerosis
Effects of Intranasal Estradiol Treatment on Serum Paraoxonase and Lipids in Healthy, Postmenopausal Women.
Atherosclerosis
Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity.
Atherosclerosis
Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet.
Atherosclerosis
Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.
Atherosclerosis
Genetic-dietary regulation of serum paraoxonase expression and its role in atherogenesis in a mouse model.
Atherosclerosis
High prevalence of low serum paraoxonase-1 in subjects with coronary artery disease.
Atherosclerosis
Human paraoxonase-1 activity in childhood obesity and its relation to leptin and adiponectin levels.
Atherosclerosis
In vivo administration of BL-3050: highly stable engineered PON1-HDL complexes.
Atherosclerosis
Interaction between metabolic syndrome and PON1 polymorphisms as a determinant of the risk of coronary artery disease.
Atherosclerosis
Is it just paraoxonase 1 or are other members of the paraoxonase gene family implicated in atherosclerosis?
Atherosclerosis
Lack of association between carotid intima-media thickness and paraoxonase gene polymorphism in non-insulin dependent diabetes mellitus.
Atherosclerosis
Lack of association between serum paraoxonase 1 activities and increased oxidized low-density lipoprotein levels in impaired glucose tolerance and newly diagnosed diabetes mellitus.
Atherosclerosis
Lack of association between the paraoxonase 1 Q/R192 single nucleotide polymorphism and stroke in a Chinese cohort.
Atherosclerosis
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.
Atherosclerosis
Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation.
Atherosclerosis
Oxidative Stress Biomarkers and Peripheral Endothelial Dysfunction in Rheumatoid Arthritis: A Monocentric Cross-Sectional Case-Control Study.
Atherosclerosis
p-Cymene Modulate Oxidative Stress and Inflammation in Murine Macrophages: Potential Implication in atherosclerosis.
Atherosclerosis
Paraoxonase activity and genetic polymorphisms in greenhouse workers with long term pesticide exposure.
Atherosclerosis
Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia.
Atherosclerosis
Paraoxonase genotype, LDL-oxidation and carotid atherosclerosis in male life-long smokers.
Atherosclerosis
Paraoxonase status in coronary heart disease: are activity and concentration more important than genotype?
Atherosclerosis
Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.
Atherosclerosis
Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance.
Atherosclerosis
Paraoxonase-1 does not reduce or modify oxidation of phospholipids by peroxynitrite.
Atherosclerosis
Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease.
Atherosclerosis
Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.
Atherosclerosis
Plasma Paraoxonase-1, Oxidized Low-Density Lipoprotein and Lipid Peroxidation Levels in Gout Patients.
Atherosclerosis
Protectors or Traitors: The Roles of PON2 and PON3 in Atherosclerosis and Cancer.
Atherosclerosis
R-carrying genotypes of serum paraoxonase (PON1) 192 polymorphism and higher activity ratio are related to susceptibility against ischemic stroke.
Atherosclerosis
Role of JNK and c-Jun signaling pathway in regulation of human serum paraoxonase-1 gene transcription by berberine in human HepG2 cells.
Atherosclerosis
Semiautomated method for determination of serum paraoxonase activity using paraoxon as substrate.
Atherosclerosis
Serum arylesterase/diazoxonase activity and genetic polymorphisms in patients with type 2 diabetes.
Atherosclerosis
Serum paraoxonase activity and protein thiols in chronic renal failure patients.
Atherosclerosis
Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins.
Atherosclerosis
Serum paraoxonase level and paraoxonase polymorphism in patients with acromegaly.
Atherosclerosis
Serum paraoxonase-1 activity in women with endometriosis and its relationship with the stage of the disease.
Atherosclerosis
Serum PON-1 Activity but not Q192R Polymorphism is Related to the Extent of Atherosclerosis.
Atherosclerosis
Some indazoles reduced the activity of human serum paraoxonase 1, an antioxidant enzyme: in vitro inhibition and molecular modeling studies.
Atherosclerosis
The development of human sera tests for HDL-bound serum PON1 and its lipolactonase activity.
Atherosclerosis
The paraoxonase promoter polymorphism (-107)T>C is not associated with carotid intima-media thickness in Sicilian hypercholesterolemic patients.
Atherosclerosis
Ultrasensitive assay for detection of serum paraoxonase by modulating the growth of fluorescent semiconductor nanoparticles.
Breast Neoplasms
Association of Serum Paraoxonase 1 Activities, Polymorphisms and Oxidative Stress in Breast Cancer Patients with Type 2 Diabetes Mellitus.
Breast Neoplasms
Serum paraoxonase and arylesterase can be useful markers to predict neoadjuvant chemotherapy requirement in patients with breast cancer.
Brucellosis
Serum paraoxonase activity, total thiols levels, and oxidative status in patients with acute brucellosis.
Carcinogenesis
Assessment of serum paraoxonase and arylesterase activity in patients with endometrial cancer.
Carcinoma
Differential immunohistochemical expression of paraoxonase-2 in actinic keratosis and squamous cell carcinoma.
Carcinoma
Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma.
Carcinoma
Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma.
Carcinoma
Serum paraoxonase activity and oxidative DNA damage in patients with laryngeal squamous cell carcinoma.
Carcinoma, Hepatocellular
Amphenicol and Macrolide Derived Antibiotics Inhibit Paraoxonase Enzyme Activity in Human Serum and Human Hepatoma Cells (HepG2) in vitro.
Carcinoma, Hepatocellular
Analysis of Serum Paraoxonase 1 Using Mass Spectrometry and Lectin Immunoassay in Patients With Alpha-Fetoprotein Negative Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Diagnosis of AFP-negative early-stage hepatocellular carcinoma using Fuc-PON1.
Carcinoma, Hepatocellular
Dietary polyphenols increase paraoxonase 1 gene expression by an aryl hydrocarbon receptor-dependent mechanism.
Carcinoma, Hepatocellular
Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis.
Carcinoma, Hepatocellular
Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation.
Carcinoma, Hepatocellular
Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins.
Carcinoma, Hepatocellular
Paraoxonase 3 inhibits cell proliferation and serves as a prognostic predictor in hepatocellular carcinoma.
Carcinoma, Hepatocellular
Serum fucosylated paraoxonase 1 as a potential glycobiomarker for clinical diagnosis of early hepatocellular carcinoma using ELISA Index.
Carcinoma, Hepatocellular
Serum paraoxonase 1 heteroplasmon, a fucosylated, and sialylated glycoprotein in distinguishing early hepatocellular carcinoma from liver cirrhosis patients.
Carcinoma, Ovarian Epithelial
Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer.
Carcinoma, Squamous Cell
Differential immunohistochemical expression of paraoxonase-2 in actinic keratosis and squamous cell carcinoma.
Cardiomyopathy, Dilated
Serum paraoxonase activity in patients with ischaemic and nonischaemic dilated cardiomyopathy.
Cardiovascular Diseases
Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes.
Cardiovascular Diseases
Concerning the Significance of Paraoxonase-1 and SR-B1 Genes in Atherosclerosis.
Cardiovascular Diseases
Effects of red wine consumption on serum paraoxonase/arylesterase activities and on lipoprotein oxidizability in healthy-men.
Cardiovascular Diseases
Evaluation of the impacts of antibiotic drugs on PON 1; a major bioscavenger against cardiovascular diseases.
Cardiovascular Diseases
Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease.
Cardiovascular Diseases
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus.
Cardiovascular Diseases
Oxidative inactivation of paraoxonase--implications in diabetes mellitus and atherosclerosis.
Cardiovascular Diseases
Paraoxonase 1 R/Q alleles are associated with differential accumulation of saturated versus 20:5n3 fatty acid in human adipose tissue.
Cardiovascular Diseases
Paraoxonase phenotype distribution in a healthy Iranian population.
Cardiovascular Diseases
PON1 concentration and high-density lipoprotein characteristics as cardiovascular biomarkers.
Cardiovascular Diseases
Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases.
Cardiovascular Diseases
The combined effect of paraoxonase promoter and coding region polymorphisms on the risk of arterial ischemic stroke among young adults.
Carotid Artery Diseases
Paraoxonase-1: Characteristics and role in atherosclerosis and carotid artery disease.
Carotid Artery Diseases
Risk of carotid atherosclerosis is associated with low serum paraoxonase (PON1) activity among arsenic exposed residents in Southwestern Taiwan.
Carotid Artery Diseases
The associations between serum paraoxonase 1 activity and carotid atherosclerosis in renal transplant patients.
Cerebral Hemorrhage
Lack of association between the paraoxonase 1 Q/R192 single nucleotide polymorphism and stroke in a Chinese cohort.
Cerebral Infarction
Human serum paraoxonase gene polymorphisms, Q192R and L55M, are not associated with the risk of cerebral infarction in Chinese Han population.
Cholelithiasis
Response to: Serum paraoxonase and malondialdehyde levels in asymptomatic cholelithiasis.
Cholelithiasis
Serum paraoxonase and malondialdehyde levels in asymptomatic cholelithiasis.
Chorioamnionitis
Prolidase, matrix metalloproteinases 1 and 13 activity, oxidative-antioxidative status as a marker of preterm premature rupture of membranes and chorioamnionitis in maternal vaginal washing fluids.
Colitis
Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-? production from CD4 T cells.
Colitis, Ulcerative
Paraoxonase-1 and arylesterase levels in patients with ulcerative colitis.
Colitis, Ulcerative
Serum paraoxonase 1 activity and malondialdehyde levels in patients with ulcerative colitis.
Condylomata Acuminata
Determining oxidant and antioxidant status in patients with genital warts.
Coronary Artery Disease
A preliminary study of human paraoxonase and PON 1 L/M55-PON 1 Q/R 192 polymorphisms in Turkish patients with coronary artery disease.
Coronary Artery Disease
Antibodies against N?-homocysteinylated proteins in patients on different methods of renal replacement therapy.
Coronary Artery Disease
Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.
Coronary Artery Disease
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease.
Coronary Artery Disease
Association of cys 311 ser polymorphism of paraoxonase-2 gene with the risk of coronary artery disease.
Coronary Artery Disease
Association of serum paraoxonase activity and coronary artery calcification.
Coronary Artery Disease
Cardiovascular diseases: oxidative damage and antioxidant protection.
Coronary Artery Disease
Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk.
Coronary Artery Disease
Coronary artery disease risk factors in patients with schizophrenia: effects of short term antipsychotic treatment.
Coronary Artery Disease
High prevalence of low serum paraoxonase-1 in subjects with coronary artery disease.
Coronary Artery Disease
Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease.
Coronary Artery Disease
Novel serum paraoxonase activity assays are associated with coronary artery disease.
Coronary Artery Disease
Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease.
Coronary Artery Disease
Paraoxonase and arylesterase activities in stent restenosis in bare metal stent.
Coronary Artery Disease
PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease.
Coronary Artery Disease
Q192R polymorphism of the paraoxanase 1 gene and its association with serum lipoprotein variables and carotid artery intima-media thickness in young adults from a biracial community. The Bogalusa Heart Study.
Coronary Artery Disease
Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus.
Coronary Artery Disease
Serum PON-1 Activity but not Q192R Polymorphism is Related to the Extent of Atherosclerosis.
Coronary Artery Disease
Smoking is associated with reduced serum paraoxonase activity and concentration in patients with coronary artery disease.
Coronary Disease
Daily moderate alcohol consumption increases serum paraoxonase activity; a diet-controlled, randomised intervention study in middle-aged men.
Coronary Disease
Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies.
Coronary Disease
Human serum paraoxonase gene polymorphisms, Q192R and L55M, are not associated with the risk of cerebral infarction in Chinese Han population.
Coronary Disease
Plasma homocysteine thiolactone adducts associated with risk of coronary heart disease.
Coronary Disease
Serum paraoxonase activity and phenotype distribution in Turkish subjects with coronary heart disease and its relationship to serum lipids and lipoproteins.
Coronary Disease
The effect of micronised fenofibrate on paraoxonase activity in patients with coronary heart disease.
Coronary Stenosis
PON-1 Activity and Plasma 8-Isoprostane Concentration in Patients with Angiographically Proven Coronary Artery Disease.
Deafness
Paraoxonase 3 gene polymorphisms are associated with occupational noise-induced deafness: A matched case-control study from China.
Deafness
[Association between single nucleotide polymorphisms of PON2 gene and susceptibility to occupational noise-induced deafness among Chinese Han population exposed to high noise levels].
Dementia
Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases.
Dementia
Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study.
Dementia, Vascular
Codon 311 (Cys --> Ser) polymorphism of paraoxonase-2 gene is associated with apolipoprotein E4 allele in both Alzheimer's and vascular dementias.
Dementia, Vascular
Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases.
Dementia, Vascular
PON-1 and ferroxidase activities in older patients with mild cognitive impairment, late onset Alzheimer's disease or vascular dementia.
Dementia, Vascular
Serum paraoxonase activity changes in patients with Alzheimer's disease and vascular dementia.
Dementia, Vascular
Serum paraoxonase and arylesterase activities of paraoxonase-1 (PON-1), mild cognitive impairment, and 2-year conversion to dementia: A pilot study.
Diabetes Complications
Association between PON 1 polymorphisms, PON activity and diabetes complications.
Diabetes Complications
Serum paraoxonase activity and its relationship to diabetic complications in patients with non-insulin-dependent diabetes mellitus.
Diabetes Complications
The paraoxonase-2-310 polymorphism is associated with the presence of microvascular complications in diabetes mellitus.
Diabetes Mellitus
A case control study on HDL associated PON1 enzyme level in Northern Indian type 2 diabetes mellitus patients.
Diabetes Mellitus
A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus.
Diabetes Mellitus
Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy.
Diabetes Mellitus
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease.
Diabetes Mellitus
Association of polymorphism of ser311cys paraoxonase-2 gene with type 2 diabetes mellitus in iran.
Diabetes Mellitus
Association of Serum Paraoxonase 1 Activities, Polymorphisms and Oxidative Stress in Breast Cancer Patients with Type 2 Diabetes Mellitus.
Diabetes Mellitus
Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats.
Diabetes Mellitus
Effects of rosiglitazone on serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus.
Diabetes Mellitus
High prevalence of low serum paraoxonase-1 in subjects with coronary artery disease.
Diabetes Mellitus
Human serum paraoxonase gene polymorphisms, Q192R and L55M, are not associated with the risk of cerebral infarction in Chinese Han population.
Diabetes Mellitus
Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia.
Diabetes Mellitus
Increased LCAT activity and hyperglycaemia decrease the antioxidative functionality of HDL.
Diabetes Mellitus
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus.
Diabetes Mellitus
Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay.
Diabetes Mellitus
Lack of association between serum paraoxonase 1 activities and increased oxidized low-density lipoprotein levels in impaired glucose tolerance and newly diagnosed diabetes mellitus.
Diabetes Mellitus
Liver paraoxonase 3 expression and the effect of liraglutide treatment in a rat model of diabetes.
Diabetes Mellitus
Paraoxonase 1: a better atherosclerotic risk predictor than HDL in type 2 diabetes mellitus.
Diabetes Mellitus
Paraoxonase 55 and 192 polymorphism and its relationship to serum paraoxonase activity and serum lipids in Turkish patients with non-insulin dependent diabetes mellitus.
Diabetes Mellitus
Paraoxonase and arylesterase activities in the serum of two hyperlipoproteinaemic patients after repeated extracorporal lipid precipitation.
Diabetes Mellitus
Paraoxonase-1 activity is positively related to phospholipid transfer protein activity in type 2 diabetes mellitus: Role of large HDL particles.
Diabetes Mellitus
Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus.
Diabetes Mellitus
Serum paraoxonase activity and genotype distribution in Japanese patients with diabetes mellitus.
Diabetes Mellitus
Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus.
Diabetes Mellitus
Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins.
Diabetes Mellitus
[Study of SOD and PON-1 expression in type 2 diabetes mellitus nephropathy and its clinical significance].
Diabetes Mellitus
[The effects of paraoxonase-1 and oxidized low density lipoprotein on nephropathy in type-2 diabetes mellitus]
Diabetes Mellitus, Type 1
Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy.
Diabetes Mellitus, Type 1
Serum paraoxonase activity in familial hypercholesterolaemia and insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 1
Serum paraoxonase activity in patients with type 1 diabetes compared to healthy controls.
Diabetes Mellitus, Type 2
A case control study on HDL associated PON1 enzyme level in Northern Indian type 2 diabetes mellitus patients.
Diabetes Mellitus, Type 2
A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
A randomised controlled trial of increasing fruit and vegetable intake and how this influences the carotenoid concentration and activities of PON-1 and LCAT in HDL from subjects with type 2 diabetes.
Diabetes Mellitus, Type 2
Are PON1 Q/R 192 and M/L 55 polymorphisms risk factors for diabetes complications in Turkish population?
Diabetes Mellitus, Type 2
Association of polymorphism of ser311cys paraoxonase-2 gene with type 2 diabetes mellitus in iran.
Diabetes Mellitus, Type 2
Association of Serum Paraoxonase 1 Activities, Polymorphisms and Oxidative Stress in Breast Cancer Patients with Type 2 Diabetes Mellitus.
Diabetes Mellitus, Type 2
Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Effects of rosiglitazone on serum paraoxonase activity and metabolic parameters in patients with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Gemfibrozil increases paraoxonase activity in type 2 diabetic patients. A new hypothesis of the beneficial action of fibrates?
Diabetes Mellitus, Type 2
Incident type 2 diabetes is associated with HDL, but not with its anti-oxidant constituent - paraoxonase-1: The prospective cohort PREVEND study.
Diabetes Mellitus, Type 2
Increased LCAT activity and hyperglycaemia decrease the antioxidative functionality of HDL.
Diabetes Mellitus, Type 2
Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Investigation of the relationship between atherosclerosis and paraoxonase or homocysteine thiolactonase activity in patients with type 2 diabetes mellitus using a commercially available assay.
Diabetes Mellitus, Type 2
Paraoxonase 1: a better atherosclerotic risk predictor than HDL in type 2 diabetes mellitus.
Diabetes Mellitus, Type 2
Paraoxonase-1 activity is positively related to phospholipid transfer protein activity in type 2 diabetes mellitus: Role of large HDL particles.
Diabetes Mellitus, Type 2
Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Paraoxonase-2 variants potentially influence insulin resistance, beta-cell function, and their interrelationships with alanine aminotransferase in type 2 diabetes.
Diabetes Mellitus, Type 2
Relationships between polymorphisms of the human serum paraoxonase gene and insulin sensitivity in Japanese patients with type 2 diabetes.
Diabetes Mellitus, Type 2
Serum paraoxonase activity and genotype distribution in Japanese patients with diabetes mellitus.
Diabetes Mellitus, Type 2
Serum paraoxonase activity and its relationship to diabetic complications in patients with non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes.
Diabetes Mellitus, Type 2
The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes.
Diabetes Mellitus, Type 2
The effect of Omega-3 fatty acids on serum paraoxonase activity, vitamins A, E, and C in type 2 diabetic patients.
Diabetes Mellitus, Type 2
[Study of SOD and PON-1 expression in type 2 diabetes mellitus nephropathy and its clinical significance].
Diabetes Mellitus, Type 2
[The effects of paraoxonase-1 and oxidized low density lipoprotein on nephropathy in type-2 diabetes mellitus]
Diabetes, Gestational
Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus.
Diabetic Retinopathy
Antioxidant potential, paraoxonase 1, ceruloplasmin activity and C-reactive protein concentration in diabetic retinopathy.
Drug Resistant Epilepsy
An evaluation of serum paraoxonase together with arylesterase activities and oxidative stress in children with intractable epilepsy: a cross-sectional study.
Dyslipidemias
Association of serum paraoxonase enzyme activity and oxidative stress markers with dyslipidemia in obese adolescents.
Dyslipidemias
Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats.
Dyslipidemias
Gemfibrozil increases paraoxonase activity in type 2 diabetic patients. A new hypothesis of the beneficial action of fibrates?
Dyslipidemias
Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia.
Dyslipidemias
THE EFFECT OF ATORVASTATINUM IN THE TREATMENT OF PATIENTS WITH RHEUMATOID ARTHRITIS.
Endometrial Neoplasms
Assessment of serum paraoxonase and arylesterase activity in patients with endometrial cancer.
Endometrial Neoplasms
Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer.
Endometriosis
Serum paraoxonase-1 activity in women with endometriosis and its relationship with the stage of the disease.
Endometriosis
Serum tumor necrosis factor-?, interleukin-6, monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis, PCOS, or unexplained infertility.
Endometriosis
There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study.
Endotoxemia
Serial measurements of Paraoxonase-1 (PON-1) activity in horses with experimentally induced endotoxemia.
Esophageal Neoplasms
Paraoxonase 3 is involved in the multi-drug resistance of esophageal cancer.
Exfoliation Syndrome
Evaluation of oxidative stress and paraoxonase phenotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Fatty Liver
A new marker for lipid peroxidation: Serum paraoxonase activity in non-alcoholic steatohepatitis.
Fatty Liver
Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents.
Glaucoma
Evaluation of oxidative stress and paraoxonase phenotypes in pseudoexfoliation syndrome and pseudoexfoliation glaucoma.
Glioma
Paraoxonase 192 gene polymorphism and serum paraoxonase activity in high grade gliomas and meningiomas.
Glucose Intolerance
Lack of association between serum paraoxonase 1 activities and increased oxidized low-density lipoprotein levels in impaired glucose tolerance and newly diagnosed diabetes mellitus.
Glucose Metabolism Disorders
Serum paraoxonase and cholinesterase activities in individuals with lipid and glucose metabolism disorders.
Head and Neck Neoplasms
Do CO2 and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients.
Hearing Loss, Sensorineural
Prognostic value of serum anti-heat-shock protein 70 and paraoxonase levels in idiopathic sudden sensorineural hearing loss.
Heart Diseases
Decreased paraoxonase and arylesterase activities in the pathogenesis of future atherosclerotic heart disease in women with gestational diabetes mellitus.
Heart Diseases
Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS?
Heart Diseases
New paraoxonase 1 polymorphism I102V and the risk of prostate cancer in Finnish men.
Hepatitis B
Serum paraoxonase and arylesterase activities in various forms of hepatitis B virus infection.
Hepatitis, Chronic
Serum arylesterase and paraoxonase activity in patients with chronic hepatitis.
Hepatitis, Chronic
Serum paraoxonase and arylesterase activities for the evaluation of patients with chronic hepatitis.
Homocystinuria
Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: Possible implications for cardiovascular outcomes.
Hydatidiform Mole
No association between serum paraoxonase, arylesterase activities, and hydatidiform mole.
Hypercholesterolemia
Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients.
Hyperglycemia
The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation.
Hyperlipidemias
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease.
Hyperlipidemias
Preanalytical variables affecting the measurement of serum paraoxonase-1 activity in horses.
Hyperlipidemias
The effect of fenofibrate on serum paraoxonase activity and inflammatory markers in patients with combined hyperlipidemia.
Hyperlipidemias
The effect of micronised fenofibrate on paraoxonase activity in patients with coronary heart disease.
Hyperlipidemias
The effect of red grape seed extract on serum paraoxonase activity in patients with mild to moderate hyperlipidemia.
Hyperlipidemias
The serum paraoxonase activity in patients with chronic renal failure and hyperlipidemia.
Hyperlipoproteinemia Type II
Visfatin, PON-1 Levels in Iraqi Hyperthyroidism Patient's with Dyslipidemia.
Hyperlipoproteinemias
The effect of micronised fenofibrate on paraoxonase activity in patients with coronary heart disease.
Hyperlipoproteinemias
The serum paraoxonase activity in patients with chronic renal failure and hyperlipidemia.
Hyperoxaluria
Phytotherapy in a rat model of hyperoxaluria: the antioxidant effects of quercetin involve serum paraoxonase 1 activation.
Hyperpigmentation
Activated neuro-oxidative and neuro-nitrosative pathways at the end of term are associated with inflammation and physio-somatic and depression symptoms, while predicting outcome characteristics in mother and baby.
Hypertension
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease.
Hypertension
Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid.
Hypertension
The inverse association of HDL-cholesterol with future risk of hypertension is not modified by its antioxidant constituent, paraoxonase-1: The PREVEND prospective cohort study.
Hyperthyroidism
Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients.
Hyperthyroidism
Subclinical Hyperthyroidism: Status of the Cholesterol Transfers to HDL and Other Parameters Related to Lipoprotein Metabolism in Patients Submitted to Thyroidectomy for Thyroid Cancer.
Hyperthyroidism
Visfatin, PON-1 Levels in Iraqi Hyperthyroidism Patient's with Dyslipidemia.
Hypertriglyceridemia
Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients.
Hypertriglyceridemia
Interrelationships of serum paraoxonase, serum lipids and apolipoproteins in normal pregnancy. A longitudinal study.
Hypothyroidism
Effect of levothyroxine replacement therapy on paraoxonase-1 and carotid intima-media thickness in subclinical hypothyroidism.
Hypothyroidism
High-dose taurine supplementation increases serum paraoxonase and arylesterase activities in experimental hypothyroidism.
Hypothyroidism
Levothyroxine improves Paraoxonase (PON-1) serum levels in patients with primary hypothyroidism: Case-control study.
Hypothyroidism
Oxidative stress and serum paraoxonase activity in experimental hypothyroidism: effect of vitamin E supplementation.
Hypothyroidism
Serum lipids, tHcy, hs-CRP, MDA and PON-1 levels in SCH and overt hypothyroidism: effect of treatment.
Infections
Application of mass spectrometry to elucidate the pathophysiology of Encephalitozoon cuniculi infection in rabbits.
Infections
Assessing protection against OP pesticides and nerve agents provided by wild-type HuPON1 purified from Trichoplusia ni larvae or induced via adenoviral infection.
Infections
Decreased serum paraoxonase-1 activity during intestinal nematode (Nippostrongylus brasiliensis) infection in rats.
Infections
Directed Enzyme Evolution and Encapsulation in Peptide Nanospheres of Quorum Quenching Lactonase as an Antibacterial Treatment against Plant Pathogen.
Infections
Expression of Pseudomonas phosphotriesterase activity in the fall armyworm confers resistance to insecticides.
Infections
Gene delivery of paraoxonase-1 inhibits neointimal hyperplasia after arterial balloon-injury in rabbits fed a high-fat diet.
Infections
Paraoxonases-2 and -3 Are Important Defense Enzymes against Pseudomonas aeruginosa Virulence Factors due to Their Anti-Oxidative and Anti-Inflammatory Properties.
Infertility
Serum tumor necrosis factor-?, interleukin-6, monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis, PCOS, or unexplained infertility.
Infertility, Female
Association between Serum Paraoxonase 1 Activities (PONase/AREase) and L55M Polymorphism in Risk of Female Infertility.
Infertility, Male
[Clinical value of seminal paraoxonase-1 activity evaluation in the diagnosis of male infertility].
Insulin Resistance
Association of serum paraoxonase activity with insulin sensitivity and oxidative stress in hyperthyroid and TSH-suppressed nodular goitre patients.
Insulin Resistance
Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance and genomic variants related to inflammation, oxidative stress and iron metabolism.
Insulin Resistance
Effect of insulin resistance on serum paraoxonase activity in a nondiabetic population.
Insulin Resistance
Lower Serum Paraoxonase-1 Activity Is Related to Linoleic and Docosahexanoic Fatty Acids in Patients with Type 2 Diabetes.
Insulin Resistance
Paraoxonase-2 variants potentially influence insulin resistance, beta-cell function, and their interrelationships with alanine aminotransferase in type 2 diabetes.
Insulin Resistance
Relationships between polymorphisms of the human serum paraoxonase gene and insulin sensitivity in Japanese patients with type 2 diabetes.
Iron Deficiencies
Paraoxonase activity in athletes with depleted iron stores and iron-deficient erythropoiesis.
Ischemic Stroke
R-carrying genotypes of serum paraoxonase (PON1) 192 polymorphism and higher activity ratio are related to susceptibility against ischemic stroke.
Ischemic Stroke
Relation of Paraoxonase1, Arylesterase and Lipid Profile in Ischemic Stroke Patients.
Ischemic Stroke
The salt stimulation property of serum paraoxonase (PON1) could be a valuable factor in evaluating the enzyme status in ischemic stroke: the role of activity-determined PON1 192Q/R phenotypes.
Keratosis, Actinic
Differential immunohistochemical expression of paraoxonase-2 in actinic keratosis and squamous cell carcinoma.
Ketosis
Predictive Value of Plasma Parameters in the Risk of Postpartum Ketosis in Dairy Cows.
Kidney Failure, Chronic
Activity of paraoxonase 1 (PON1) on HDL2 and HDL3 subclasses in renal disease.
Kidney Failure, Chronic
Paraoxonase activity and antibodies to oxidized-LDL in chronic renal failure patients on renal replacement therapy.
Kidney Failure, Chronic
Paraoxonase-1 and ischemia-modified albumin in patients with end-stage renal disease.
Kidney Failure, Chronic
Paraoxonase-1 concentrations in end-stage renal disease patients increase after hemodialysis: correlation with low molecular AGE adduct clearance.
Kidney Failure, Chronic
Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis.
Kidney Failure, Chronic
Serum paraoxonase activity and protein thiols in chronic renal failure patients.
Kidney Failure, Chronic
Serum paraoxonase activity, high-sensitivity C-reactive protein, and lipoprotein disturbances in end-stage renal disease patients on long-term hemodialysis.
Kidney Failure, Chronic
Serum paraoxonase and platelet-activating factor acetylhydrolase in chronic renal failure.
Kidney Failure, Chronic
The serum paraoxonase activity in patients with chronic renal failure and hyperlipidemia.
Leukemia
The anti-apoptotic PON2 protein is Wnt/?-catenin-regulated and correlates with radiotherapy resistance in OSCC patients.
Leukemia, Myeloid, Acute
The activities of serum paraoxonase and arylesterase and lipid profile in acute myeloid leukemia: preliminary results.
Liver Cirrhosis
Serum fucosylated paraoxonase 1 as a potential glycobiomarker for clinical diagnosis of early hepatocellular carcinoma using ELISA Index.
Liver Cirrhosis
Serum paraoxonase 1 heteroplasmon, a fucosylated, and sialylated glycoprotein in distinguishing early hepatocellular carcinoma from liver cirrhosis patients.
Liver Diseases
Baseline and salt-stimulated paraoxonase and arylesterase activities in patients with chronic liver disease: relation to disease severity.
Liver Diseases
Baseline and Salt-stimulated Paraoxonase and Arylesterase Activities in Patients with Chronic Liver Disease: Relation with Disease Severity.
Liver Diseases
Serum paraoxonase 1 activity is paradoxically maintained in nonalcoholic fatty liver disease despite low HDL cholesterol.
Liver Diseases
Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents.
Liver Diseases
Serum paraoxonase and arylesterase activities in Iranian patients with nonalcoholic fatty liver disease.
Liver Diseases, Alcoholic
Serum paraoxonase in alcohol abusers associated with alcoholic liver disease.
Lung Diseases
Serum paraoxonase and arylesterase activities in patients with pulmonary tuberculosis.
Lung Neoplasms
Integrated Glycoproteomics Demonstrates Fucosylated Serum Paraoxonase 1 Alterations in Small Cell Lung Cancer.
Lung Neoplasms
Serum paraoxonase and arylesterase activities in patients with lung cancer in a Turkish population.
Lupus Erythematosus, Systemic
Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Relationship of serum paraoxonase 1 activity and paraoxonase 1 genotype to risk of systemic lupus erythematosus.
Macular Degeneration
Decreased serum paraoxonase 1 activity and increased serum homocysteine and malondialdehyde levels in age-related macular degeneration.
Macular Degeneration
Serum paraoxonase 1 activity and lipid peroxidation levels in patients with age-related macular degeneration.
Macular Degeneration
Serum Paraoxonase activity in relation to lipid profile in Age-related Macular Degeneration patients.
Macular Degeneration
SERUM PARAOXONASE PHENOTYPE DISTRIBUTION IN EXUDATIVE AGE-RELATED MACULAR DEGENERATION AND ITS RELATIONSHIP TO HOMOCYSTEINE AND OXIDIZED LOW-DENSITY LIPOPROTEIN.
Melanoma
Paraoxonase-2 Silencing Enhances Sensitivity of A375 Melanoma Cells to Treatment with Cisplatin.
Meningioma
Paraoxonase 192 gene polymorphism and serum paraoxonase activity in high grade gliomas and meningiomas.
Metabolic Syndrome
Low levels of serum paraoxonase activities are characteristic of metabolic syndrome and may influence the metabolic-syndrome-related risk of coronary artery disease.
Metabolic Syndrome
Lower serum paraoxonase-1 activity is related to higher serum amyloid a levels in metabolic syndrome.
Metabolic Syndrome
Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation.
Metabolic Syndrome
Relationship of serum resistin level to traits of metabolic syndrome and serum paraoxonase 1 activity in a population with a broad range of body mass index.
Metabolic Syndrome
Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents.
Metabolic Syndrome
Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran.
Metabolic Syndrome
Serum paraoxonase-1 activities and oxidative status in patients with plaque-type psoriasis with/without metabolic syndrome.
Metabolic Syndrome
The positive relationship of serum paraoxonase-1 activity with apolipoprotein E is abrogated in metabolic syndrome.
Metabolic Syndrome
The role of abnormalities of lipoproteins and HDL functionality in small fibre dysfunction in people with severe obesity.
Microvascular Angina
Paraoxonase and arylesterase activities in patients with cardiac syndrome X, and their relationship with oxidative stress markers.
Microvascular Angina
Serum paraoxonase 1 activity and oxidative markers of LDL in patients with cardiac syndrome X.
Migraine Disorders
Paraoxonase 1 gene polymorphisms, paraoxonase/arylesterase activities and oxidized low-density lipoprotein levels in patients with migraine.
Multiple Sclerosis
Association between serum paraoxonase 1 activity and its polymorphisms with multiple sclerosis: a systematic review.
Multiple Sclerosis
Decreased arylesterase activity of paraoxonase-1 (PON-1) might be a common denominator of neuroinflammatory and neurodegenerative diseases.
Multiple Sclerosis
Serum paraoxonase and arylesterase activity and oxidative status in patients with multiple sclerosis.
Multiple Sclerosis, Relapsing-Remitting
Serum paraoxonase and arylesterase activity and oxidative status in patients with multiple sclerosis.
Myocardial Infarction
Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction.
Myocardial Infarction
Clinical and Genetic Association of Serum Paraoxonase and Arylesterase Activities With Cardiovascular Risk.
Myocardial Infarction
Relationship between Paraoxonase-1 and Arylesterase Enzyme Activities and SYNTAX I and II Scores in Patients with ST-Elevation Myocardial Infarction.
Myocardial Infarction
Serum Paraoxonase (PON1) Activity in North-West Indian Punjabi's with Acute Myocardial Infarction.
Myocardial Infarction
Smoking is associated with reduced serum paraoxonase, antioxidants and increased oxidative stress in normolipidaemic acute myocardial infarct patients.
Myocardial Infarction
The Gln/Arg polymorphism of human paraoxonase (PON 192) is not related to myocardial infarction in the ECTIM Study.
Myocardial Infarction
[Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction]
Myocardial Ischemia
Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.
Nasal Polyps
Serum paraoxonase, arylesterase activity, and oxidative status in patients with nasal polyp.
Neonatal Sepsis
Paraoxonase (PON)-1 activity in septic neonates: One more arrow in the quiver of biomarkers of neonatal sepsis?
Neonatal Sepsis
Total Antioxidan Level, Total Oxidan Level and Serum Paraoxonase-1 Levels in Neonatal Sepsis.
Neoplasm Metastasis
Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma.
Neoplasms
Is there a relation between genetic susceptibility with cancer? A study about paraoxanase (PON1) enzyme activity in breast cancer cases.
Neoplasms
Mechanistic insights and perspectives involved in neuroprotective action of quercetin.
Neoplasms
Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis.
Neoplasms
Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma.
Neoplasms
Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis.
Neoplasms
Physical activity is associated with a large number of cardiovascular-specific proteins: Cross-sectional analyses in two independent cohorts.
Neoplasms
The anti-apoptotic PON2 protein is Wnt/?-catenin-regulated and correlates with radiotherapy resistance in OSCC patients.
Neoplasms
The anti-inflammatory function of HDL is impaired in type 2 diabetes: role of hyperglycemia, paraoxonase-1 and low grade inflammation.
Neoplasms, Squamous Cell
Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis.
Neoplasms, Squamous Cell
The anti-apoptotic PON2 protein is Wnt/?-catenin-regulated and correlates with radiotherapy resistance in OSCC patients.
Nephrotic Syndrome
Serum paraoxonase activity and oxidative stress in patients with adult nephrotic syndrome.
Neuroblastoma
Degradation of organophosphorus neurotoxicity in SY5Y neuroblastoma cells by organophosphorus hydrolase (OPH).
Non-alcoholic Fatty Liver Disease
Paraoxonase 1 and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis.
Non-alcoholic Fatty Liver Disease
Serum paraoxonase 1 activity is paradoxically maintained in nonalcoholic fatty liver disease despite low HDL cholesterol.
Non-alcoholic Fatty Liver Disease
Serum paraoxonase activity and oxidative stress and their relationship with obesity-related metabolic syndrome and non-alcoholic fatty liver disease in obese children and adolescents.
Non-alcoholic Fatty Liver Disease
Serum paraoxonase and arylesterase activities in Iranian patients with nonalcoholic fatty liver disease.
Obesity
Association between paraoxonase activity and lipid levels in patients with premature coronary artery disease.
Obesity
Changes in lipid profile parameters and PON1 status associated with L55M PON1 polymorphism, overweight and exposure to tobacco smoke.
Obesity
Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.
Obesity
Gender related differences in paraoxonase 1 response to high-fat diet-induced oxidative stress.
Obesity
Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia.
Obesity
Non-diabetic metabolic syndrome and obesity do not affect serum paraoxonase and arylesterase activities but do affect oxidative stress and inflammation.
Osteoarthritis
Expression of proteins in serum, synovial fluid, synovial membrane, and articular cartilage samples obtained from dogs with stifle joint osteoarthritis secondary to cranial cruciate ligament disease and dogs without stifle joint arthritis.
Osteoarthritis, Knee
Assessment of paraoxonase activities in patients with knee osteoarthritis.
Osteonecrosis
Association of a polymorphism in PON-1 gene with steroid-induced osteonecrosis of femoral head in Chinese Han population.
Otitis Media
Serum paraoxonase and arylesterase activities in patients with chronic otitis media.
Overweight
Changes in lipid profile parameters and PON1 status associated with L55M PON1 polymorphism, overweight and exposure to tobacco smoke.
Overweight
Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.
Overweight
Polycystic ovary syndrome and endothelial dysfunction: A potential role for soluble lectin-like oxidized low density lipoprotein receptor-1.
Pancreatitis
Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity and lipid profile in experimental acute pancreatitis.
Pancreatitis
Serum paraoxonase (a high-density lipoprotein-associated lipophilic antioxidant) activity in clinical follow-up of patients with acute pancreatitis, with particular emphasis on oxidative stress parameters and lipid profile: a prospective pilot trial.
Pancreatitis
Serum paraoxonase undergoes inhibition and proteolysis during experimental acute pancreatitis.
Pancreatitis, Chronic
Decreased Serum Paraoxonase Activity in Patients With Chronic Pancreatitis.
Parkinson Disease
Paraoxonase 1 polymorphisms L55M and Q192R were not risk factors for Parkinson's disease: a HuGE review and meta-analysis.
Parkinson Disease
Paraoxonase and arylesterase activity and total oxidative/anti-oxidative status in patients with idiopathic Parkinson's disease.
Peripheral Nervous System Diseases
Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipids and lipoproteins.
Polycystic Kidney Diseases
A mouse kidney- and liver-expressed cDNA having homology with a prokaryotic parathion hydrolase (phosphotriesterase)-encoding gene: abnormal expression in injured and polycystic kidneys.
Polycystic Ovary Syndrome
Benefits of omega-3 Fatty acids supplementation on serum paraoxonase 1 activity and lipids ratios in polycystic ovary syndrome.
Polycystic Ovary Syndrome
Serum paraoxonase 1 activity and oxidant/antioxidant status in Saudi women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
Serum paraoxonase 1 activity, asymmetric dimethylarginine levels, and brachial artery flow-mediated dilatation in women with polycystic ovary syndrome.
Polycystic Ovary Syndrome
The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women.
Pre-Eclampsia
Levels of oxidized LDL, estrogens, and progesterone in placenta tissues and serum paraoxonase activity in preeclampsia.
Pre-Eclampsia
Oxidizability of apolipoprotein B-containing lipoproteins and serum paraoxonase/arylesterase activities in preeclampsia.
Pre-Eclampsia
Serum levels of lipids, lipoproteins and paraoxonase activity in pre-eclampsia.
Prostatic Neoplasms
Enhanced HDL-cholesterol-associated anti-oxidant PON-1 activity in prostate cancer patients.
Proteinuria
Serum paraoxonase activity and oxidative stress in patients with adult nephrotic syndrome.
Psoriasis
Association Between Oxidation-Modified Lipoproteins and Coronary Plaque in Psoriasis.
Psoriasis
HDL associated paraoxonase-1 activity correlates with systemic inflammation, disease activity and cardiovascular risk factors in psoriatic disease.
Psoriasis
Serum paraoxonase-1 activities and oxidative status in patients with plaque-type psoriasis with/without metabolic syndrome.
Pulmonary Disease, Chronic Obstructive
Evaluation of serum paraoxonase and arylesterase activities in subjects with asthma and chronic obstructive lung disease.
Renal Insufficiency
Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients.
Renal Insufficiency, Chronic
Circulating Lactonase Activity but Not Protein Level of PON-1 Predicts Adverse Outcomes in Subjects with Chronic Kidney Disease.
Renal Insufficiency, Chronic
Comparison of serum paraoxonase and arylesterase activities between iron deficiency anemia patients and chronic kidney disease patients with anemia.
Renal Insufficiency, Chronic
Diminished antioxidant activity of high-density lipoprotein-associated proteins in chronic kidney disease.
Renal Insufficiency, Chronic
Serum Paraoxonase Levels are Correlated with Impaired Aortic Functions in Patients with Chronic Kidney Disease.
Rosacea
Assessment of decreased serum paraoxonase activity in patients with rosacea in terms of methodology.
Rosacea
Response to 'Letter to the editor' by Agilli et al. entitled 'Assessment of decreased serum paraoxonase activity in patients with rosacea in terms of methodology'
Sepsis
Identification of Protein Carbonyls (PCOs) in Canine Serum by Western Blot Technique and Preliminary Evaluation of PCO Concentration in Dogs With Systemic Inflammation.
Sepsis
Oxidative stress parameters and inflammatory and immune mediators as markers of the severity of sepsis.
Sepsis
Paraoxonase (PON)-1 activity in septic neonates: One more arrow in the quiver of biomarkers of neonatal sepsis?
Sepsis
Prognostic value of serum paraoxonase and arylesterase activity in patients with sepsis.
Sepsis
The diagnostic and prognostic value of paraoxonase-1 and butyrylcholinesterase activities compared with acute-phase proteins in septic dogs and stratified by the acute patient physiologic and laboratory evaluation score.
Sleep Apnea, Obstructive
Serum paraoxonase, arylesterase activity and oxidative status in patients with obstructive sleep apnea syndrome (OSAS).
Sleep Initiation and Maintenance Disorders
Serum paraoxonase, arylesterase activities and oxidative status in patients with insomnia.
Small Cell Lung Carcinoma
Integrated Glycoproteomics Demonstrates Fucosylated Serum Paraoxonase 1 Alterations in Small Cell Lung Cancer.
Spondylitis, Ankylosing
Carotid intima-media thickness and paraoxonase activity in patients with ankylosing spondylitis.
Spondylitis, Ankylosing
Evaluation of serum paraoxonase and arylesterase activities in ankylosing spondylitis patients.
Squamous Cell Carcinoma of Head and Neck
Measurement of serum paraoxonase activity and MDA concentrations in patients suffering with oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Oral squamous cell carcinoma and serum paraoxonase 1.
Squamous Cell Carcinoma of Head and Neck
Paraoxonase 3 promotes cell proliferation and metastasis by PI3K/Akt in oral squamous cell carcinoma.
Squamous Cell Carcinoma of Head and Neck
Serum paraoxonase activity and oxidative DNA damage in patients with laryngeal squamous cell carcinoma.
ST Elevation Myocardial Infarction
Oxidative Stress and Paraoxonase 1 Activity Predict Contrast-Induced Nephropathy in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.
ST Elevation Myocardial Infarction
Relationship between Paraoxonase-1 and Arylesterase Enzyme Activities and SYNTAX I and II Scores in Patients with ST-Elevation Myocardial Infarction.
Stomach Neoplasms
The clinical and prognostic significance of paraoxonase-2 in gastric cancer patients: immunohistochemical analysis.
Stomatitis, Aphthous
Assessment of the serum paraoxonase activity and oxidant/antioxidant status in patients with recurrent aphthous stomatitis.
Stroke
Anti-(apolipoprotein A-1) IgGs are associated with high levels of oxidized low-density lipoprotein in acute coronary syndrome.
Stroke, Lacunar
Serum paraoxonase and arylesterase activities in patients with lacunar infarction: a case control study.
Tuberculosis
Overexpression, crystallization and preliminary X-ray crystallographic analysis of the phosphotriesterase from Mycobacterium tuberculosis.
Tuberculosis
Serum paraoxonase and arylesterase activities in patients with pulmonary tuberculosis.
Tuberculosis, Pulmonary
Serum paraoxonase 1 activity and oxidative stress in pediatric patients with pulmonary tuberculosis.
Tuberculosis, Pulmonary
Serum paraoxonase and arylesterase activities in patients with pulmonary tuberculosis.
Urinary Bladder Neoplasms
Bladder Cancer Chemosensitivity is Affected by Paraoxonase-2 Expression.
Urinary Bladder Neoplasms
Exploring the role of paraoxonase-2 in bladder cancer: analyses performed on tissue samples, urines and cell cultures.
Vascular Diseases
Endothelial dysfunction and atherosclerosis in rheumatoid arthritis: a multiparametric analysis using imaging techniques and laboratory markers of inflammation and autoimmunity.
Vascular Diseases
Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention.
Vascular Diseases
Paraoxonase-1 (PON1) activity as a risk factor for atherosclerosis in chronic renal failure patients.
Vascular Diseases
Serum paraoxonase is reduced in type 1 diabetic patients compared to non-diabetic, first degree relatives; influence on the ability of HDL to protect LDL from oxidation.
Vascular Diseases
The salt stimulation property of serum paraoxonase (PON1) could be a valuable factor in evaluating the enzyme status in ischemic stroke: the role of activity-determined PON1 192Q/R phenotypes.
Vitamin A Deficiency
Alterations in the lipid metabolism of rat aorta: effects of vitamin a deficiency.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
Michaelis-Menten kinetics
-
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
the enzyme is a member of phosphotriesterase-like lactonase family. The phosphotriesterase activities of phosphotriesterases (PTEs) are considered to derive from the lactonase-activities during the evolution, and phosphotriesterase-like lactonase family (PLL), is the closest protein family to PTE family based on protein-protein blast results. But members of PLL family exhibit higher lactonase activities than the phosphotriesterase activities, while the best substrates for PTEs are phosphotriesters. Enzyme mPHP is a dimer with a typical distorted (beta/alpha)8 barrel structure like other structures of PLL family and PTE family
additional information
the architecture of active pocket of enzyme mPHP coordinates with two metal ions, substrate binding structure, structre comparisons, overview
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). PHP_MYCTU
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
326
0
35886
Swiss-Prot
-
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
enzyme mPHP is a dimer with a typical distorted (beta/alpha)8 barrel structure like other structures of PLL family and PTE family
additional information
the monomeric mPHP is a distorted (beta/alpha)8 barrel. The eight beta-strands (beta3-beta10) form the inner barrel wall which surrounds the substrate binding pocket. The eight alpha-helices are roughly parallel to each other and form a twist barrel outside the inner beta barrel, secondary structure analysis, structure comparisons, overview
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purified recombinant N-terminally His6-tagged enzyme with bound Zn2+, X-ray diffraction structure determination and analysis at 2.3 A resolution, the first residue of the N-terminal (Met1) and the last residue of the C-terminal (Gln326) are missing due to the lack of density. Molecular replacement, the structure of phosphotriesterase from Sulfolobus solfataricus (SsoPox), PDB ID 2VC5, is used as the search model
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, L.; Wang, H.; Liu, X.; Zhou, W.; Rao, Z.
The crystal structure of the phosphotriesterase from M. tuberculosis, another member of phosphotriesterase-like lactonase family
Biochem. Biophys. Res. Commun.
510
224-229
2019
Mycobacterium tuberculosis (P9WHN9), Mycobacterium tuberculosis H37Rv (P9WHN9), Mycobacterium tuberculosis ATCC 25618 (P9WHN9)
brenda
EXTERNAL LINKS (specific for EC-Number 3.1.8.1)
Transporter Classification Database (TCDB): 1.A.6.2.6
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
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