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Information on EC 3.1.6.4 - N-acetylgalactosamine-6-sulfatase and Organism(s) Rattus norvegicus and UniProt Accession P50430

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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.4 N-acetylgalactosamine-6-sulfatase
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This record set is specific for:
Rattus norvegicus
UNIPROT: P50430 not found.
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Word Map
The taxonomic range for the selected organisms is: Rattus norvegicus
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
galns, n-acetylgalactosamine-6-sulfate sulfatase, n-acetylgalactosamine-6-sulfatase, 6-sulfatase, chondroitin sulfatase, n-acetylgalactosamine 6-sulfatase, galactose-6-sulfatase, galactose-6-sulfate sulfatase, n-acetylgalactosamine 6-sulphate sulphatase, atsa2, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6-sulfatase
-
-
acetylgalactosamine 6-sulfatase
-
-
-
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chondroitin sulfatase
-
-
-
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chondroitinase
-
-
-
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chondroitinsulfatase
-
-
-
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galactose-6-sulfate sulfatase
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-
-
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GalNAc6S sulfatase
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-
-
-
GALNS
-
-
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N-acetylgalactosamine 6-sulfatase
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-
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N-acetylgalactosamine 6-sulphate sulphatase
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-
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N-acetylgalactosamine-6-sulfate sulfatase
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-
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sulfatase, acetylgalactosamine 6-
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-
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sulfatase, chondroitin
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-
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-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of sulfuric ester
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-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase
-
CAS REGISTRY NUMBER
COMMENTARY hide
59299-00-2
-
9025-60-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
chondroitin-6-sulfate + H2O
chondroitin + sulfate
show the reaction diagram
-
6-sulfated tetrasaccharide from chondroitin-6-sulfate
-
?
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)2 + H2O
sulfate + ?
show the reaction diagram
-
-
-
-
?
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)3 + H2O
sulfate + ?
show the reaction diagram
-
-
-
-
?
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)4 + H2O
sulfate + ?
show the reaction diagram
-
-
-
-
?
GalNAc-4-SO4-GlcUA-GalNAc-4-SO4 + H2O
sulfate + ?
show the reaction diagram
-
-
-
-
?
N-acetyl-D-glucosamine 6-sulfate units + H2O
N-acetyl-D-glucosamine units + sulfate
show the reaction diagram
-
in chondroitin sulfate or keratan sulfate, decreased enzymatic activity in fasting rats
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.03
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)2
-
-
0.049
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)3
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-
0.064
GalNAc-4-SO4-(GlcUA-GalNAc-4-SO4)4
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-
0.027
GalNAc-4-SO4-GlcUA-GalNAc-4-SO4
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-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
5.6
-
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
in post-natal ventral rat prostate, a distinct and reciprocal localization of arylsulfatase B and N-acetylgalactosamine-6-sulfatase is seen, with arylsulfatase B predominant in the stroma and N-acetylgalactosamine-6-sulfatase predominant in the epithelium. Estrogen treatment does not inhibit the increase in GALNS activity between days 5 and 30
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
in post-natal ventral rat prostate, a distinct and reciprocal localization of arylsulfatase B and N-acetylgalactosamine-6-sulfatase is seen, with arylsulfatase B predominant in the stroma and N-acetylgalactosamine-6-sulfatase predominant in the epithelium. Estrogen treatment does not inhibit the increase in GALNS activity between days 5 and 30
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
ARSB_RAT
528
0
58959
Swiss-Prot
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Habuchi, H.; Tsuji, M.; Nakanishi, Y.; Suzuki, S.
Separation and properties of five glycosaminoglycan sulfatases from rat skin
J. Biol. Chem.
254
7570-7578
1979
Rattus norvegicus
Manually annotated by BRENDA team
Cechowska-Pasko, M.; Wolanska, M.; Pallka, J.
Glycosaminoglycan-degrading enzymes in the skin of fasted rats
Comp. Biochem. Physiol. B
131
551-557
2002
Rattus norvegicus
Manually annotated by BRENDA team
Feferman, L.; Bhattacharyya, S.; Birch, L.; Prins, G.S.; Tobacman, J.K.
Differential effects of estrogen exposure on arylsulfatase B, galactose-6-sulfatase, and steroid sulfatase in rat prostate development
J. Steroid Biochem. Mol. Biol.
143
105-114
2014
Rattus norvegicus (P50430)
Manually annotated by BRENDA team