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Disease on EC 3.1.3.76 - lipid-phosphate phosphatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma of Lung
Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in lung cancer cells.
Alzheimer Disease
PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.
The lipid phosphatase Synaptojanin 1 undergoes a significant alteration in expression and solubility and is associated with brain lesions in Alzheimer's disease.
Arthritis, Rheumatoid
Inhibition of lipid phosphatase SHIP1 expands myeloid-derived suppressor cells and attenuates rheumatoid arthritis in mice.
Asthma
Secretory Inositol Polyphosphate 4-Phosphatase Protects Against Airway Inflammation and Remodeling.
Breast Neoplasms
BAG5 regulates PTEN stability in MCF-7 cell line.
Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells.
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model.
Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.
Carcinogenesis
Conditional deletion of Pten causes bronchiolar hyperplasia.
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway.
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.
Preparation and characterization of a polyclonal antibody against PTEN-Long.
PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis.
Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.
Carcinoma
Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus.
Carcinoma, Squamous Cell
Detection of functional PTEN lipid phosphatase protein and enzyme activity in squamous cell carcinomas of the head and neck, despite loss of heterozygosity at this locus.
Charcot-Marie-Tooth Disease
Cerebral hypomyelination associated with biallelic variants of FIG4.
Distinctive genetic and clinical features of CMT4J: a severe neuropathy caused by mutations in the PI(3,5)P? phosphatase FIG4.
The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signaling.
Colonic Neoplasms
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer.
Regulation of TRAIL expression by the phosphatidylinositol 3-kinase/Akt/GSK-3 pathway in human colon cancer cells.
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice.
Dengue
PTEN Lipid Phosphatase Activity Enhances Dengue Virus Production through Akt/FoxO1/Maf1 Signaling.
Dent Disease
Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.
Glioblastoma
Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.
Proteome profile changes that are differentially regulated by lipid and protein phosphatase activities of tumor suppressor PTEN in PTEN-expressing U-87 MG human glioblastoma cells.
Glioma
A role for nuclear PTEN in neuronal differentiation.
Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.
Profiling of genes expressed by PTEN haploinsufficient neural precursor cells.
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
PTEN increases autophagy and inhibits the ubiquitin-proteasome pathway in glioma cells independently of its lipid phosphatase activity.
The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration.
The PTEN lipid phosphatase domain is not required to inhibit invasion of glioma cells.
Hamartoma Syndrome, Multiple
Allele-specific tumor spectrum in pten knockin mice.
Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin.
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
Hearing Loss
Hair Bundle Defects and Loss of Function in the Vestibular End Organs of Mice Lacking the Receptor-Like Inositol Lipid Phosphatase PTPRQ.
Hypertension, Pulmonary
Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition.
Infections
Inhibition of mycobacterial infection by the tumor suppressor PTEN.
The PTEN tumor suppressor inhibits telomerase activity in endometrial cancer cells by decreasing hTERT mRNA levels.
The role of PTEN - HCV core interaction in hepatitis C virus replication.
Insulin Resistance
Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome.
GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues.
Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity.
Intellectual Disability
A role for nuclear PTEN in neuronal differentiation.
Profiling of genes expressed by PTEN haploinsufficient neural precursor cells.
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
Leukemia
INPP4B: the new kid on the PI3K block.
Long QT Syndrome
Oxidative inactivation of the lipid phosphatase phosphatase and tensin homolog on chromosome ten (PTEN) as a novel mechanism of acquired long QT syndrome.
Lung Neoplasms
Invasiveness and anchorage independent growth ability augmented by PTEN inactivation through the PI3K/AKT/NFkB pathway in lung cancer cells.
Measles
Measles virus induces expression of SIP110, a constitutively membrane clustered lipid phosphatase, which inhibits T cell proliferation.
Megalencephaly
A role for nuclear PTEN in neuronal differentiation.
Profiling of genes expressed by PTEN haploinsufficient neural precursor cells.
PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation.
Melanoma
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Muscular Diseases
Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment.
Myopathies, Structural, Congenital
Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations.
Enzyme replacement therapy rescues weakness and improves muscle pathology in mice with X-linked myotubular myopathy.
Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice.
Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish.
Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment.
Pathogenic deep intronic MTM1 variant activates a pseudo-exon encoding a nonsense codon resulting in severe X-linked myotubular myopathy.
SPEG interacts with myotubularin, and its deficiency causes centronuclear myopathy with dilated cardiomyopathy.
The myotubularin family: novel phosphoinositide regulators.
Neoplasm Metastasis
Decreased Peritoneal Ovarian Cancer Growth in Mice Lacking Expression of Lipid Phosphate Phosphohydrolase 1.
Promotion of melanoma cell invasion and tumor metastasis by microcystin-LR via phosphatidylinositol 3-kinase/AKT pathway.
Neoplasms
A glutamate switch controls voltage-sensitive phosphatase function.
A high-avidity biosensor reveals plasma membrane PI(3,4)P2 is predominantly a class I PI3K signaling product.
A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer.
A Tumor Suppressor Function for the Lipid Phosphatase INPP4B in Melanocytic Neoplasms.
Activation of tumor suppressor protein PTEN and induction of apoptosis are involved in cAMP-mediated inhibition of cell number in B92 glial cells.
AIF inhibits tumor metastasis by protecting PTEN from oxidation.
AKT involvement in cisplatin chemoresistance of human uterine cancer cells.
Allele-specific tumor spectrum in pten knockin mice.
Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region.
Analysis of Site-specific Phosphorylation of PTEN using Enzyme-Catalyzed Expressed Protein Ligation.
Biophysical methods for the characterization of PTEN/lipid bilayer interactions.
Brothers with germline PTEN mutations and persistent hypoglycemia, macrocephaly, developmental delay, short stature, and coagulopathy.
Catalysis by the tumor-suppressor enzymes PTEN and PTEN-L.
Cell cycle arrest by the PTEN tumor suppressor is target cell specific and may require protein phosphatase activity.
Characterization of a tumor-associated activating mutation of the p110? PI 3-kinase.
Chemoprevention and treatment of experimental Cowden's disease by mTOR inhibition with rapamycin.
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase.
Conditional deletion of Pten causes bronchiolar hyperplasia.
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production.
Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair.
Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function.
Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells.
Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma.
Cowden syndrome with bronchial asthma.
Defining the Membrane-Associated State of the PTEN Tumor Suppressor Protein.
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.
Differential expression of PTEN in normal adult rat brain and upregulation of PTEN and p-Akt in the ischemic cerebral cortex.
Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten.
Effective PI3K modulators for improved therapy against malignant tumors and for neuroprotection of brain damage after tumor therapy (Review).
Enzymatic Analysis of PTEN Ubiquitylation by WWP2 and NEDD4-1 E3 Ligases.
Essential role for nuclear PTEN in maintaining chromosomal integrity.
Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.
Expansion of CD133 expressing liver cancer stem cells in liver specific PTEN deleted mice.
Faithfull Modeling of PTEN Loss Driven Diseases in the Mouse.
Focus on PTEN Regulation.
Functional Analysis of the Protein Phosphatase Activity of PTEN.
Functional evaluation of PTEN missense mutations using in vitro phosphoinositide phosphatase assay.
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis.
GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN.
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.
Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice.
Identification of nucleolus-localized PTEN and its function in regulating ribosome biogenesis.
Identification of PTEN at the ER and MAMs and its regulation of Ca(2+) signaling and apoptosis in a protein phosphatase-dependent manner.
Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer.
Implication of the MAGI-1b/PTEN signalosome in stabilization of adherens junctions and suppression of invasiveness.
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Inhibition of mycobacterial infection by the tumor suppressor PTEN.
Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.
INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression.
INPP4B Is a Tumor Suppressor in the Context of PTEN Deficiency.
INPP4B: the new kid on the PI3K block.
Insight into the PTEN - p85? interaction and lipid binding properties of the p85? BH domain.
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Loss of phosphatase activity in PTEN (phosphatase and tensin homolog deleted on chromosome ten) results in endometrial carcinoma in humans: An in-silico study.
Loss of PTEN selectively desensitizes upstream IGF1 and insulin signaling.
Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
MADD is a downstream target of PTEN in triggering apoptosis.
Metabolic switching of PI3K-dependent lipid signals.
miR-22 forms a regulatory loop in PTEN/AKT pathway and modulates signaling kinetics.
Molecular Features of Phosphatase and Tensin Homolog (PTEN) Regulation by C-terminal Phosphorylation.
Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Mutation of the PTEN gene in a human hepatic angiosarcoma.
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity.
Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.
Novel approaches to inhibitor design for the p110? phosphoinositide 3-kinase.
Over expression of PTEN induces apoptosis and prevents cell proliferation in breast cancer cells.
p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control.
p85 Associates with unphosphorylated PTEN and the PTEN-associated complex.
Perspective: Potential Impact and Therapeutic Implications of Oncogenic PI3K Activation on Chromosomal Instability.
Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells.
Phosphatase and Tensin Homolog in Non-neoplastic Digestive Disease: More Than Just Tumor Suppressor.
Phospholipid-binding Sites of Phosphatase and Tensin Homolog (PTEN): EXPLORING THE MECHANISM OF PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE ACTIVATION.
Phosphorylation by Akt within the ST loop of AMPK-?1 down-regulates its activation in tumour cells.
PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.
Protein interactions of PTEN and its cancer-associated G20E mutant compared by stable isotope labeling by amino acids in cell culture -based parallel affinity purification.
Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells.
PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase.
PTEN action in leukaemia dictated by the tissue microenvironment.
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity.
PTEN controls tumor-induced angiogenesis.
PTEN expression in non-small-cell lung cancer: evaluating its relation to tumor characteristics, allelic loss, and epigenetic alteration.
PTEN function in mammalian cell size regulation.
PTEN gene and integrin signaling in cancer.
PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development.
PTEN in brain tumors.
PTEN inhibition enhances angiogenesis in an in vitro model of ischemic injury by promoting Akt phosphorylation and subsequent hypoxia inducible factor-1? upregulation.
PTEN Inhibition in Human Disease Therapy.
PTEN inhibitors: an evaluation of current compounds.
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
PTEN is a protein tyrosine phosphatase for IRS1.
PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis.
PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis.
PTEN loss in the continuum of common cancers, rare syndromes and mouse models.
PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7.
PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors.
PTEN Protein Phosphatase Activity Correlates with Control of Gene Expression and Invasion, a Tumor-Suppressing Phenotype, But Not with AKT Activity.
Pten regulates collective cell migration during specification of the anterior-posterior axis of the mouse embryo.
PTEN regulates phospholipase D and phospholipase C.
PTEN regulation of ERK1/2 signaling in cancer.
PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex.
PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression.
PTEN signaling in brain: neuropathology and tumorigenesis.
PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha.
PTEN-Associated Complexes: An Overview.
PTEN: a yin-yang master regulator protein in health and disease.
Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway.
Regulated and Polarized PtdIns(3,4,5)P3 Accumulation Is Essential for Apical Membrane Morphogenesis in Photoreceptor Epithelial Cells.
Regulation and modulation of PTEN activity.
Regulation of T cell homeostasis and responses by pten.
RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation.
Role of PTEN, a lipid phosphatase upstream effector of protein kinase B, in epithelial thyroid carcinogenesis.
Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease.
S-nitrosylation of PTEN Invovled in Ischemic Brain Injury in Rat Hippocampal CA1 Region.
Successful targeting of ErbB2 receptors-is PTEN the key?
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.
The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor.
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
The lipid phosphatase activity of PTEN is critical for its tumor supressor function.
The MMAC1 tumor suppressor phosphatase inhibits phospholipase C and integrin-linked kinase activity.
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment.
The regulation of cell migration by PTEN.
The tumor suppressor PTEN interacts with p53 in hereditary cancer (Review).
Therapeutic targeting of cancers with loss of PTEN function.
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity.
Transient strong reduction of PTEN expression by specific RNAi induces loss of adhesion of the cells.
Turning off AKT: PHLPP as a drug target.
Ubiquitin Ligase Activities of WWP1 Germline Variants K740N and N745S.
WWP2 is an E3 ubiquitin ligase for PTEN.
[PTEN tumor suppressor: functions as a lipid phosphatase]
[Study on the PTEN Tumor Suppressor Gene]
Neurodegenerative Diseases
Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease.
Oculocerebrorenal Syndrome
OCRL1 function in renal epithelial membrane traffic.
Rab35 GTPase Triggers Switch-like Recruitment of the Lowe Syndrome Lipid Phosphatase OCRL on Newborn Endosomes.
Suppression of intestinal calcium entry channel TRPV6 by OCRL, a lipid phosphatase associated with Lowe syndrome and Dent disease.
Ovarian Neoplasms
Decreased Peritoneal Ovarian Cancer Growth in Mice Lacking Expression of Lipid Phosphate Phosphohydrolase 1.
INPP4B: the new kid on the PI3K block.
Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment.
Papilloma
Phosphatidylinositol 3-kinase regulates early differentiation in human laryngeal keratinocytes.
Parkinson Disease
The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals.
Parkinsonian Disorders
Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
Peripheral Nervous System Diseases
Cerebral hypomyelination associated with biallelic variants of FIG4.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.
Prostatic Neoplasms
A Tumor Suppressor Function for the Lipid Phosphatase INPP4B in Melanocytic Neoplasms.
Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer.
Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.
Phenotypic effects of overexpression of the MMAC1 gene in prostate epithelial cells.
Pro-survival function of Akt/protein kinase B in prostate cancer cells. Relationship with TRAIL resistance.
Prostate cancer, PI3K, PTEN and prognosis.
Pulmonary Disease, Chronic Obstructive
Cigarette smoke extract amplifies NADPH oxidase-dependent ROS production to inactivate PTEN by oxidation in BEAS-2B cells.
Seizures
Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
Stomach Neoplasms
PTEN lipid phosphatase inactivation links the hippo and PI3K/Akt pathways to induce gastric tumorigenesis.
Teratoma
AKT signaling promotes derivation of embryonic germ cells from primordial germ cells.
Thymoma
Turning off AKT: PHLPP as a drug target.
Thyroid Neoplasms
PTEN Lipid Phosphatase Activity and Proper Subcellular Localization Are Necessary and Sufficient for Down-Regulating AKT Phosphorylation in the Nucleus in Cowden Syndrome.
Triple Negative Breast Neoplasms
PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?
The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
Tuberculosis
Mechanism of phagolysosome biogenesis block by viable Mycobacterium tuberculosis.
Tuberous Sclerosis
Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies.
Targeting phosphoinositide 3-kinase: moving towards therapy.
Urinary Bladder Neoplasms
PTEN can inhibit in vitro organotypic and in vivo orthotopic invasion of human bladder cancer cells even in the absence of its lipid phosphatase activity.