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Acute Lung Injury
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction.
Acute Lung Injury
The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo.
Adenoviridae Infections
Up-regulation of Rhoa/Rho kinase pathway by translationally controlled tumor protein in vascular smooth muscle cells.
Asthma
Airway Hyperresponsiveness in Asthma Model Occurs Independently of Secretion of ?1 Integrins in Airway Wall and Focal Adhesions Proteins Down Regulation.
Atherosclerosis
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Atherosclerosis
Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells.
Atherosclerosis
ROS-mediated downregulation of MYPT1 in smooth muscle cells: a potential mechanism for the aberrant contractility in atherosclerosis.
Atrial Fibrillation
Expression of Rho Kinase and Its Mechanism in the Left Atrial Appendage in Patients with Atrial Fibrillation.
Bacterial Infections
Signatures of selection reveal candidate genes involved in economic traits and cold acclimation in five Swedish cattle breeds.
Breast Neoplasms
Epanorin, a lichen secondary metabolite, inhibits proliferation of MCF-7 breast cancer cells.
Breast Neoplasms
The effect of deoxyfluorination and O-acylation on the cytotoxicity of N-acetyl-D-gluco- and D-galactosamine hemiacetals.
Carcinogenesis
Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness.
Carcinogenesis
Myosin phosphatase: Unexpected functions of a long-known enzyme.
Carcinogenesis
MYPT1, regulated by miR-19b-3p inhibits the progression of non-small cell lung cancer via inhibiting the activation of wnt/?-catenin signaling.
Carcinoma, Hepatocellular
Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Synthesis, X-ray, Hirshfeld surface analysis, exploration of DNA binding, urease enzyme inhibition and anticancer activities of novel adamantane-naphthyl thiourea conjugate.
Carcinoma, Neuroendocrine
A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Carcinoma, Non-Small-Cell Lung
MYPT1, regulated by miR-19b-3p inhibits the progression of non-small cell lung cancer via inhibiting the activation of wnt/?-catenin signaling.
Colitis
Involvement of CPI-17 downregulation in the dysmotility of the colon from dextran sodium sulphate-induced experimental colitis in a mouse model.
Colonic Neoplasms
Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells.
Colorectal Neoplasms
DNA targeting half sandwich Ru(II)-p-cymene-N^N complexes as cancer cell imaging and terminating agents: influence of regioisomers in cytotoxicity.
Colorectal Neoplasms
PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy.
Coronary Occlusion
Myosin phosphatase isoforms and related transcripts in the pig coronary circulation and effects of exercise and chronic occlusion.
Cystic Fibrosis
Rising behind NO: cGMP-dependent protein kinases.
Cysts
Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.
Diabetes Mellitus, Experimental
Augmented contractility of murine femoral arteries in a streptozotocin diabetes model is related to increased phosphorylation of MYPT1.
Diabetes Mellitus, Type 2
Regulation of Smooth Muscle Myosin Light Chain Phosphatase by Multi-site Phosphorylation of the Myosin Targeting Subunit, MYPT1.
Disorders of Sex Development
Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.
Endometrial Neoplasms
[Screening, cloning and identification of the human endometrial carcinoma-related genes]
Endotoxemia
Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
Enterocolitis, Necrotizing
Expression of MYPT1, CPI-17 and MLC20 in ileum of neonatal mouse NEC model and its significance.
Enterocolitis, Necrotizing
Inhibition of miR-124 improves neonatal necrotizing enterocolitis via an MYPT1 and TLR9 signal regulation mechanism.
Frontotemporal Dementia
FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extract.
Gastroparesis
Impaired contractile responses and altered expression and phosphorylation of Ca(2+) sensitization proteins in gastric antrum smooth muscles from ob/ob mice.
Glioblastoma
Real time kinetic flow cytometry measurements of cellular parameter changes evoked by nanosecond pulsed electric field.
Heart Failure
HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half.
Heart Failure
Losartan decreases p42/44 MAPK signaling and preserves LZ+ MYPT1 expression.
Heart Failure
The potential role of MLC phosphatase and MAPK signalling in the pathogenesis of vascular dysfunction in heart failure.
Hirschsprung Disease
MYPT1 Down-regulation by Lipopolysaccharide-SIAH1/2 E3 Ligase-Ubiquitin-Proteasomal Degradation Contributes to Colonic Obstruction of Hirschsprung Disease.
Holoprosencephaly
Loss-of-Function Variants in PPP1R12A: From Isolated Sex Reversal to Holoprosencephaly Spectrum and Urogenital Malformations.
Hyperalgesia
Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinase?A as a Structure Surrogate.
Hyperglycemia
Role of ROCK upregulation in endothelial and smooth muscle vascular functions in diabetic rat aorta.
Hypertension
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
Hypertension
Dynamic regulation of myosin light chain phosphorylation by Rho-kinase.
Hypertension
Editing of the myosin phosphatase regulatory subunit suppresses angiotensin II induced hypertension via sensitization to nitric oxide mediated vasodilation.
Hypertension
Enhanced Ca2+-dependent activation of phosphoinositide 3-kinase class II? isoform-Rho axis in blood vessels of spontaneously hypertensive rats.
Hypertension
Increased PDZ-RhoGEF/RhoA/Rho kinase signaling in small mesenteric arteries of angiotensin II-induced hypertensive rats.
Hypertension
Mechanism of ?1-Adrenergic Receptor-Induced Increased Contraction of Rat Mesenteric Artery in Aging Hypertension Rats.
Hypertension
Peach (Prunus persica) extract inhibits angiotensin II-induced signal transduction in vascular smooth muscle cells.
Hypertension
Preserved expression of GLUT4 prevents enhanced agonist-induced vascular reactivity and MYPT1 phosphorylation in hypertensive mouse aorta.
Hypertension
Resveratrol prevents AngII-induced hypertension via AMPK activation and RhoA/ROCK suppression in mice.
Hypertension
Rho kinase activation in circulating leukocytes is related to hypertensive myocardial remodeling.
Hypertension
Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy.
Hypertension, Portal
Dynamic changes in expression of myosin phosphatase in a model of portal hypertension.
Hypertension, Portal
Myosin phosphatase isoform switching in vascular smooth muscle development.
Hypertension, Pulmonary
Regulation of pulmonary arterial myosin phosphatase activity in neonatal circulatory transition and in hypoxic pulmonary hypertension: a role for CPI-17.
Hypertension, Pulmonary
The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas.
Hypertrophy, Right Ventricular
The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
Hypotension
Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.
Infections
Developing oncolytic Herpes simplex virus type 1 through UL39 knockout by CRISPR-Cas9.
Infections
Genetic Inactivation of Chlamydia trachomatis Inclusion Membrane Protein CT228 Alters MYPT1 Recruitment, Extrusion Production, and Longevity of Infection.
Infections
Insights into adenoviral vector production kinetics in acoustic filter-based perfusion cultures.
Infections
Porcine Endogenous Retrovirus (PERV) Infection of HEK-293 Cell Line Alters Expression of Human Endogenous Retrovirus (HERV-W) Sequences.
Infections
The latent human herpesvirus-6A genome specifically integrates in telomeres of human chromosomes in vivo and in vitro.
Influenza, Human
Accelerated mass production of influenza virus seed stocks in HEK-293 suspension cell cultures by reverse genetics.
Insulin Resistance
Impaired insulin-mediated vasorelaxation in diabetic Goto-Kakizaki rats is caused by impaired Akt phosphorylation.
Insulin Resistance
Myosin phosphatase: Unexpected functions of a long-known enzyme.
Leiomyosarcoma
Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1.
Leukemia, Megakaryoblastic, Acute
Inhibition by Rho-kinase and protein kinase C of myosin phosphatase is involved in thrombin-induced shape change of megakaryocytic leukemia cell line UT-7/TPO.
Lung Neoplasms
MYPT1, regulated by miR-19b-3p inhibits the progression of non-small cell lung cancer via inhibiting the activation of wnt/?-catenin signaling.
Melanoma
Melanoma-expressed CD70 is involved in invasion and metastasis.
Muscle Spasticity
Cellular and molecular mechanisms of coronary artery spasm: lessons from animal models.
Muscle Spasticity
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Muscle Spasticity
Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery.
Muscular Atrophy
Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
Myocardial Ischemia
Altered Reactivity of Tertiary Mesenteric Arteries following Acute Myocardial Ischemia.
Myotonic Dystrophy
Caenorhabditis elegans LET-502 is related to Rho-binding kinases and human myotonic dystrophy kinase and interacts genetically with a homolog of the regulatory subunit of smooth muscle myosin phosphatase to affect cell shape.
Myotonic Dystrophy
Coiled-coil interactions modulate multimerization, mitochondrial binding and kinase activity of myotonic dystrophy protein kinase splice isoforms.
Myotonic Dystrophy
Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.
Neoplasm Metastasis
Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer.
Neoplasm Metastasis
Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells.
Neoplasm Metastasis
The urokinase receptor promotes cancer metastasis independently of urokinase-type plasminogen activator in mice.
Neoplasms
Activation of Myosin Phosphatase by Epigallocatechin-Gallate Sensitizes THP-1 Leukemic Cells to Daunorubicin.
Neoplasms
Cardioprotective Effect of a Combination of Rho-Kinase Inhibitor and P38 MAPK Inhibitor on Cardiovascular Remodeling and Oxidative Stress in Dahl Rats.
Neoplasms
Chemical Composition, Antioxidant and Anticancer Activities of Leptocarpha rivularis DC Flower Extracts.
Neoplasms
Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance.
Neoplasms
Decreased Expression of MYPT1 Contributes to Tumor Angiogenesis and Poor Patient Prognosis in Human Prostate Cancer.
Neoplasms
Deficiency in myosin light-chain phosphorylation causes cytokinesis failure and multipolarity in cancer cells.
Neoplasms
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
Neoplasms
Differentially expressed soluble proteins in aortic cells from atherosclerosis-susceptible and resistant pigeons.
Neoplasms
DNA targeting half sandwich Ru(II)-p-cymene-N^N complexes as cancer cell imaging and terminating agents: influence of regioisomers in cytotoxicity.
Neoplasms
Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness.
Neoplasms
Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor.
Neoplasms
Investigations of antiproliferative and antioxidant activity of ?-lactam morpholino-1,3,5-triazine hybrids.
Neoplasms
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Neoplasms
MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer.
Neoplasms
MYPT1 is targeted by miR-145 inhibiting viability, migration and invasion in 2D and 3D HeLa cultures.
Neoplasms
MYPT1, regulated by miR-19b-3p inhibits the progression of non-small cell lung cancer via inhibiting the activation of wnt/?-catenin signaling.
Neoplasms
Offsetting Expression Profiles of Prognostic Markers in Prostate Tumor vs. Its Microenvironment.
Neoplasms
Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer.
Neoplasms
PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy.
Neoplasms
Reduction of hyaluronan-CD44-mediated growth, migration, and cisplatin resistance in head and neck cancer due to inhibition of Rho kinase and PI-3 kinase signaling.
Neoplasms
Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion.
Neoplasms
Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation.
Neoplasms
Small molecule inhibitor of nicotinamide N-methyltransferase shows anti-proliferative activity in HeLa cells.
Neoplasms
The Evolution of Duplicated Genes of the Cpi-17/Phi-1 (ppp1r14) Family of Protein Phosphatase 1 Inhibitors in Teleosts.
Neoplasms
The putative oncogene CPI-17 is up-regulated in schwannoma.
Neuroblastoma
Myosin phosphatase and RhoA-activated kinase modulate neurotransmitter release by regulating SNAP-25 of SNARE complex.
Neuroblastoma
O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins.
Neuroblastoma
The study of cellular cytotoxicity of argireline® - an anti-aging peptide.
Neurodegenerative Diseases
Myosin phosphatase: Unexpected functions of a long-known enzyme.
Ovarian Neoplasms
Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness.
Ovarian Neoplasms
Expression profiles of PRKG1, SDF2L1 and PPP1R12A are predictive and prognostic factors for therapy response and survival in high-grade serous ovarian cancer.
Pneumonia
The protective role of MLCP-mediated ERM dephosphorylation in endotoxin-induced lung injury in vitro and in vivo.
Pre-Eclampsia
Haplotype-based, case-control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy.
Prostatic Neoplasms
Decreased Expression of MYPT1 Contributes to Tumor Angiogenesis and Poor Patient Prognosis in Human Prostate Cancer.
Prostatic Neoplasms
Effects of a fluorescent Myosin light chain phosphatase inhibitor on prostate cancer cells.
Prostatic Neoplasms
Human type 3 5?-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride.
Pterygium
Activation of the Sphingosine 1 Phosphate-Rho Pathway in Pterygium and in Ultraviolet-Irradiated Normal Conjunctiva.
Pulmonary Edema
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction.
Rabies
Utility of human embryonic kidney cell line HEK-293 for rapid isolation of fixed and street rabies viruses: comparison with Neuro-2a and BHK-21 cell lines.
Retinoblastoma
Inhibition of protein phosphatase-1 and -2A decreases the chemosensitivity of leukemic cells to chemotherapeutic drugs.
Retinoblastoma
Localization of Myosin phosphatase target subunit and its mutants.
Retinoblastoma
Myosin phosphatase and RhoA-activated kinase modulate arginine methylation by the regulation of protein arginine methyltransferase 5 in hepatocellular carcinoma cells.
Retinoblastoma
Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: Its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A.
Rhabdomyosarcoma
A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Rhabdomyosarcoma, Alveolar
A comparison of adult rhabdomyosarcoma and high-grade neuroendocrine carcinoma of the urinary bladder reveals novel PPP1R12A fusions in rhabdomyosarcoma.
Sepsis
Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model.
Sepsis
Redox signaling and splicing dependent change in myosin phosphatase underlie early versus late changes in NO vasodilator reserve in a mouse LPS model of sepsis.
Shock, Septic
Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase.
Shock, Septic
The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries.
Spasm
Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.
Starvation
Metabolic Stress-Induced Activation of AMPK and Inhibition of Constitutive Phosphoproteins Controlling Smooth Muscle Contraction: Evidence for Smooth Muscle Fatigue?
Stomach Neoplasms
Overexpression of Myosin Phosphatase Target Subunit 1 (MYPT1) Inhibits Tumor Progression and Metastasis of Gastric Cancer.
Stroke
Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke.
Subarachnoid Hemorrhage
[Role of protein kinase C isozymes in cellular functions and pathological conditions]
Usher Syndromes
Cannabinoid Receptor 1 associates to different molecular complexes during GABAergic neuron maturation.
Vascular Diseases
Dynamic regulation of myosin light chain phosphorylation by Rho-kinase.
Vasospasm, Intracranial
Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm.
Vasospasm, Intracranial
Thromboxane A2-induced bi-directional regulation of cerebral arterial tone.
Whooping Cough
Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation.
[myosin-light-chain] phosphatase deficiency
Constitutive phosphorylation of myosin phosphatase targeting subunit-1 in smooth muscle.
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3.1.3.53 [myosin-light-chain] phosphatase
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
