The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
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The enzyme appears in viruses and cellular organisms
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SYSTEMATIC NAME
IUBMB Comments
validoxylamine-A 7'-phosphate phosphohydrolase
The enzyme, characterized from the bacterium Streptomyces hygroscopicus subsp. limoneus, is involved in the biosynthesis of the antifungal agent validamycin A.
validoxylamine A i.e. (1S,2S,3R,6S)-4-(hydroxymethyl)-6-[[(1S,2S,3S,4R,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclohexyl]amino]cyclohex-4-ene-1,2,3-triol
isolation and sequence analysis of the validamycin gene cluster, the cluster ends with VldH.. Hydrolase VldH could transfer the phosphate group to the hydroxyl moiety (5-hydroxyl) that is eliminated for dehydration
isolation and sequence analysis of the validamycin gene cluster, the cluster ends with VldH.. Hydrolase VldH could transfer the phosphate group to the hydroxyl moiety (5-hydroxyl) that is eliminated for dehydration
Singh, D.; Seo, M.J.; Kwon, H.J.; Rajkarnikar, A.; Kim, K.R.; Kim, S.O.; Suh, J.W.
Genetic localization and heterologous expression of validamycin biosynthetic gene cluster isolated from Streptomyces hygroscopicus var. limoneus KCCM 11405 (IFO 12704)
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History
Enzyme Nomenclature
3.1.3.101 validoxylamine A 7'-phosphate phosphatase
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