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Information on EC 3.1.11.8 - guanosine-5'-diphospho-5'-[DNA] diphosphatase

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IUBMB Comments
Aprataxin is a DNA-binding protein that catalyses (among other activities) the 5' decapping of Gpp-DNA (formed by homologs of RtcB3 from the bacterium Myxococcus xanthus). The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and eventual release. The enzyme forms a 5'-phospho terminus that can be efficiently joined by "classical" ligases. The enzyme also possesses the activitiy of EC 3.1.11.7, adenosine-5'-diphospho-5'-[DNA] diphosphatase and EC 3.1.12.2, DNA-3'-diphospho-5'-guanosine diphosphatase.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
guanosine-5'-diphospho-5'-[DNA]
+
=
phospho-5'-[DNA]
+
Synonyms
aprataxin, APTX, HNT3, pp5'G5'-DNA guanylate hydrolase, pp5'G5'DNA diphosphatase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
guanosine-5'-diphospho-5'-[DNA] + H2O = phospho-5'-[DNA] + GMP
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