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Information on EC 3.1.1.45 - carboxymethylenebutenolidase and Organism(s) Mus musculus and UniProt Accession Q8R1G2

for references in articles please use BRENDA:EC3.1.1.45
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EC Tree
     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.1 Carboxylic-ester hydrolases
                3.1.1.45 carboxymethylenebutenolidase
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This record set is specific for:
Mus musculus
UNIPROT: Q8R1G2 not found.
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Word Map
The taxonomic range for the selected organisms is: Mus musculus
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
dienelactone hydrolase, trans-dienelactone hydrolase, carboxymethylenebutenolidase, trans-dlh, carboxymethylenebutenolidase homolog, 4-carboxymethylenebut-2-en-4-olide hydrolase, cis-dienelactone hydrolase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
4-carboxymethylenebut-2-en-4-olide hydrolase
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-
-
-
carboxymethylene butenolidase
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-
-
-
carboxymethylene butenolide hydrolase
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-
-
-
dienelactone hydrolase
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-
-
-
maleylacetate enol-lactonase
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-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis of carboxylic ester
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
4-carboxymethylenebut-2-en-4-olide lactonohydrolase
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CAS REGISTRY NUMBER
COMMENTARY hide
76689-22-0
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
azilsartan medoxomil + H2O
azilsartan + ?
show the reaction diagram
-
-
-
?
candesartan cilexetil + H2O
candesartan + ?
show the reaction diagram
-
-
-
?
olmesartan medoxomil + H2O
olmesartan + diacetyl
show the reaction diagram
-
-
-
?
additional information
?
-
the activity with prodrug-type angiotensin II type 1 receptor blocker differs in a tissue-dependent and subcellular-dependent manner, overview
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-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
azilsartan medoxomil + H2O
azilsartan + ?
show the reaction diagram
-
-
-
?
candesartan cilexetil + H2O
candesartan + ?
show the reaction diagram
-
-
-
?
olmesartan medoxomil + H2O
olmesartan + diacetyl
show the reaction diagram
-
-
-
?
additional information
?
-
the activity with prodrug-type angiotensin II type 1 receptor blocker differs in a tissue-dependent and subcellular-dependent manner, overview
-
-
?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
additional information
additional information
Michaelis-Menten kinetics
-
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.4
assay at
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
37
assay at
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
the carboxymethylenebutenolidase homologue is the enzyme responsible for bioactivation of olmesartan medoxomil, prodrug-type angiotensin II type 1 receptor blocker, and also of other prodrug-type angiotensin II type 1 receptor blockers, candesartan cilexetil and azilsartan medoxomil
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CMBL_MOUSE
245
0
27902
Swiss-Prot
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Ishizuka, T.; Yoshigae, Y.; Murayama, N.; Izumi, T.
Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1
Drug Metab. Dispos.
41
1888-1895
2013
Canis lupus familiaris (E2RF91), Canis lupus familiaris, Homo sapiens (Q96DG6), Homo sapiens, Macaca fascicularis, Mus musculus (Q8R1G2), Rattus norvegicus (Q7TP52), Rattus norvegicus Sprague-Dawley (Q7TP52)
Manually annotated by BRENDA team