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Information on EC 2.7.7.B22 - transposase

for references in articles please use BRENDA:EC2.7.7.B22
preliminary BRENDA-supplied EC number
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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.B22 transposase
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This record set is specific for:
UNIPROT: Q25442
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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
binds to the ends of a transposon (DNA that moves) and catalyzes the movement of the transposon to another part of the genome by a cut and paste mechanism or a replicative transposition mechanism
Synonyms
transposase, hermes, piggybac transposase, is711, buster, tn5 transposase, sb transposase, ac transposase, sb100x, setmar, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
DNA transposase
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
enzyme Hermes is a member of the hAT transposon superfamily, which has active representatives, including McClintock's archetypal Ac mobile genetic element, in many eukaryotic species
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
Q25442_MUSDO
612
0
70110
TrEMBL
-
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
octamer
a tetramer of dimers, the dimer is the fundamental catalytic unit
additional information
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
additional information
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
full-length Hermes expressed in eukaryotic cells, such as budding yeast and Sf9 cells, similarly forms a large multimeric species consistent with an octamer as judged by gel filtration
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hickman, A.B.; Ewis, H.E.; Li, X.; Knapp, J.A.; Laver, T.; Doss, A.L.; Tolun, G.; Steven, A.C.; Grishaev, A.; Bax, A.; Atkinson, P.W.; Craig, N.L.; Dyda, F.
Structural basis of hAT transposon end recognition by Hermes, an octameric DNA transposase from Musca domestica
Cell
158
353-367
2014
Musca domestica (Q25442), Musca domestica
Manually annotated by BRENDA team