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Information on EC 2.7.7.47 - streptomycin 3''-adenylyltransferase and Organism(s) Klebsiella pneumoniae and UniProt Accession P08881

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IUBMB Comments
Also acts on spectinomycin.
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This record set is specific for:
Klebsiella pneumoniae
UNIPROT: P08881
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Word Map
The taxonomic range for the selected organisms is: Klebsiella pneumoniae
The enzyme appears in selected viruses and cellular organisms
Synonyms
aminoglycoside adenyltransferase, aminoglycoside adenylyltransferase, streptomycin adenylyltransferase, aada6, aminoglycoside 3'-adenyltransferase, smatase, aminoglycoside adenyltransferase type a, streptomycin adenyltransferase, aminoglycoside adenyltransferase a, aminoglycoside 3''-adenylyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
AAD (3'')
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aminoglycoside 3''-adenylyltransferase
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streptomycin adenylate synthetase
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streptomycin adenyltransferase
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streptomycin adenylylase
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streptomycin adenylyltransferase
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streptomycin-spectinomycin adenylyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
nucleotidyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
ATP:streptomycin 3''-adenylyltransferase
Also acts on spectinomycin.
CAS REGISTRY NUMBER
COMMENTARY hide
52660-23-8
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
clindamycin
residues Phe34, Asp60, Arg63, Gln64, Leu68, Glu87, Thr89, Val90 are responsible for positioning clindamycin into the active site
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
S3AD_KLEPN
262
0
29202
Swiss-Prot
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
modeling of enzyme structure
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
Klebsiella pneumoniae strains carrying the enzyme gene and a dihydrofolate reductase gene confering resistance to trimethoprim were found in eight out of 44 different diabetic foot ulcer patients
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Shahi, S.K.; Singh, V.K.; Kumar, A.; Gupta, S.K.; Singh, S.K.
Interaction of dihydrofolate reductase and aminoglycoside adenyltransferase enzyme from Klebsiella pneumoniae multidrug resistant strain DF12SA with clindamycin: a molecular modelling and docking study
J. Mol. Model.
19
973-983
2013
Klebsiella pneumoniae (P08881), Klebsiella pneumoniae
Manually annotated by BRENDA team