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Information on EC 2.7.7.100 - SAMP-activating enzyme

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EC Tree
     2 Transferases
         2.7 Transferring phosphorus-containing groups
             2.7.7 Nucleotidyltransferases
                2.7.7.100 SAMP-activating enzyme
IUBMB Comments
Contains Zn2+. The enzyme catalyses the activation of SAMPs (Small Archaeal Modifier Proteins), which are ubiquitin-like proteins found only in the Archaea, by catalysing the ATP-dependent formation of a SAMP adenylate in which the C-terminal glycine of SAMP is bound to AMP via an acyl-phosphate linkage. The product of this activity can accept a sulfur atom to form a thiocarboxylate moiety that acts as a sulfur carrier involved in thiolation of tRNA and other metabolites such as molybdopterin. Alternatively, the enzyme can also catalyse the transfer of SAMP from its activated form to an internal cysteine residue, leading to a process termed SAMPylation (see EC 6.2.1.55, E1 SAMP-activating enzyme).
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The expected taxonomic range for this enzyme is: Haloferax volcanii
Reaction Schemes
+
[SAMP]-Gly-Gly
=
+
[SAMP]-Gly-Gly-AMP
Synonyms
E1 Ub activating enzyme homolog, E1 ubiquitin-activating enzyme homolog of archaea, E1-like ubiquitin-activating homolog, SAMP-activating E1 enzyme, SAMP-activating enzyme E1, UbaA, ubiquitin-activating E1 enzyme homolog, ubiquitin-like activating protein of Archaea, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + [SAMP]-Gly-Gly = diphosphate + [SAMP]-Gly-Gly-AMP
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PATHWAY SOURCE
PATHWAYS
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