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Information on EC 2.7.4.3 - adenylate kinase
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2.7.4.3 adenylate kinaseIUBMB Comments
Inorganic triphosphate can also act as donor.
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Word Map
- 2.7.4.3
- phosphoenolpyruvate
- adp
- creatine
- hpr
- fructose
- nucleoside
-
permease
- streptococcus
-
phosphoenolpyruvate-dependent
- mannose
- 6-phosphate
-
catabolite
- deaminase
- lactose
- mannitol
- hexokinase
- mutans
- glucose-6-phosphate
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camp-dependent
- aminoglycoside
- autophosphorylation
- phosphoglucomutase
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phosphofructokinase
- kanamycin
- neomycin
- 6-phosphogluconate
-
phosphorelay
- 5'-nucleotidase
-
antiterminator
- mgatp
- 2-deoxyglucose
-
intermembrane
-
transphosphorylation
-
gamma-phosphate
- melibiose
- salivarius
- ganciclovir
- phosphocreatine
- nptii
-
diadenosine
-
diphosphohydrolase
-
gamma-32patp
-
p-loop
-
2.7.3.2
- dikinase
-
coarse-grained
- analysis
- phosvitin
- medicine
-
2,6-bisphosphate
- mucolipidosis
- phosphoenzyme
- diagnostics
The enzyme appears in viruses and cellular organisms
Synonyms
phosphotransferase, adenylate kinase, myokinase, adenylate kinase 1, adenylate kinase 2, nonstructural protein 4b, cinap, adenylokinase, spadk, adenylate kinase isoenzyme 1, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
5'-AMP-kinase
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adenylic kinase
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adenylokinase
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kinase, adenylate (phosphorylating)
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kinase, myo- (phosphorylating)
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myokinase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
ATP:AMP phosphotransferase
Inorganic triphosphate can also act as donor.
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CAS REGISTRY NUMBER
COMMENTARY
9013-02-9
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 ADP
ATP + AMP
pfSMCnbd possesses reverse adenylate kinase activity. In adenylate kinase reactions, ATP binds to its canonical binding site while AMP binds to the Q-loop glutamine and a hydration water of the Mg2+ ion. Furthermore, mutational analysis indicates that adenylate kinase reaction occurs in the engaged pfSMCnbd dimer and requires the Signature motif for phosphate transfer
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acquired Immunodeficiency Syndrome
Resistance pattern of cytomegalovirus (CMV) after oral valganciclovir therapy in transplant recipients at high-risk for CMV infection.
Acquired Immunodeficiency Syndrome
Single amino acid changes in the DNA polymerase confer foscarnet resistance and slow-growth phenotype, while mutations in the UL97-encoded phosphotransferase confer ganciclovir resistance in three double-resistant human cytomegalovirus strains recovered from patients with AIDS.
Acquired Immunodeficiency Syndrome
The Cys607-->Tyr change in the UL97 phosphotransferase confers ganciclovir resistance to two human cytomegalovirus strains recovered from two immunocompromised patients.
Adenocarcinoma
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Adenocarcinoma
Identification of novel DNA hypermethylation of the adenylate kinase 5 promoter in colorectal adenocarcinoma.
Adenocarcinoma
Resveratrol-induced inactivation of human gastric adenocarcinoma cells through a protein kinase C-mediated mechanism.
Adenocarcinoma of Lung
A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma.
Adenocarcinoma of Lung
Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma.
adenosine deaminase deficiency
Outcomes of patients with severe combined immunodeficiency treated with hematopoietic stem cell transplantation with and without preconditioning.
adenylate kinase deficiency
A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (Arg 107 --> Stop, CGA --> TGA) associated with chronic haemolytic anaemia.
adenylate kinase deficiency
A new member of the adenylate kinase family in yeast: PAK3 is highly homologous to mammalian AK3 and is targeted to mitochondria.
adenylate kinase deficiency
A variant of mucolipidosis. II. Clinical, biochemical and pathological investigations.
adenylate kinase deficiency
Adenylate kinase 1 deficiency disrupts mouse sperm motility under conditions of energy stress.
adenylate kinase deficiency
Adenylate kinase 1 deficiency induces molecular and structural adaptations to support muscle energy metabolism.
adenylate kinase deficiency
Adenylate kinase 2 deficiency limits survival and regulates various genes during larval stages of Drosophila melanogaster.
adenylate kinase deficiency
Congenital haemolytic anaemia associated with adenylate kinase deficiency.
adenylate kinase deficiency
Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia.
adenylate kinase deficiency
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia.
adenylate kinase deficiency
Hereditary disorders of erythrocyte enzymes in non-glycolytic metabolic pathways.
adenylate kinase deficiency
Hereditary erythrocyte adenylate kinase deficiency: a defect of multiple phosphotransferases?
adenylate kinase deficiency
Hereditary malignant hyperpyrexia associated with muscle adenylate kinase deficiency.
adenylate kinase deficiency
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.
adenylate kinase deficiency
Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.
adenylate kinase deficiency
Metabolic compensation for profound erythrocyte adenylate kinase deficiency. A hereditary enzyme defect without hemolytic anemia.
adenylate kinase deficiency
Missense mutation in the N-acetylglucosamine-1-phosphotransferase gene (GNPTA) in a patient with mucolipidosis II induces changes in the size and cellular distribution of GNPTG.
adenylate kinase deficiency
Molecular basis of red cell enzymopathies associated with hereditary nonspherocytic hemolytic anemia.
adenylate kinase deficiency
Rare hereditary nonspherocytic hemolytic anemia caused by a novel homozygous mutation, c.301C?>?A, (Q101K), in the AK1 gene in an Indian family.
adenylate kinase deficiency
Red cell adenylate kinase deficiency associated with hereditary nonspherocytic hemolytic anemia: clinical and biochemical studies.
adenylate kinase deficiency
Red cell adenylate kinase deficiency in India: identification of two novel missense mutations (c.71A>G and c.413G>A).
adenylate kinase deficiency
Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.
adenylate kinase deficiency
Red cell enzymopathies as a model of inborn errors of metabolism.
adenylate kinase deficiency
Reticular Dysgenesis and Mitochondriopathy Induced by Adenylate Kinase 2 Deficiency with Atypical Presentation.
adenylate kinase deficiency
Sensitivity of the adenine nucleotide metabolism of platelets from malignant hyperthermia patients to halothane.
adenylate kinase deficiency
Severe erythrocyte adenylate kinase deficiency due to homozygous A-->G substitution at codon 164 of human AK1 gene associated with chronic haemolytic anaemia.
adenylate kinase deficiency
Splenectomy resolves hemolytic anemia caused by adenylate kinase deficiency.
adenylate kinase deficiency
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
adenylate kinase deficiency
[A new erythroenzymopathy: congenital non-spherocytic hemolytic anemia and hereditary erythrocytic adenylate kinase deficiency]
adenylate kinase deficiency
[Acquired erythroenzymopathies. II. Adenylate kinase deficiency in hemopathies]
Alzheimer Disease
Amyloid-? peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex.
Alzheimer Disease
Profiling of p5, a 24 Amino Acid Inhibitory Peptide Derived from the CDK5 Activator, p35 CDKR1 Against 70 Protein Kinases.
amp deaminase deficiency
Levels of adenylate deaminase, adenylate kinase, and creatine kinase in frozen human muscle biopsy specimens relative to type 1/type 2 fiber distribution: evidence for a carrier state of myoadenylate deaminase deficiency.
Anemia
Metabolic compensation for profound erythrocyte adenylate kinase deficiency. A hereditary enzyme defect without hemolytic anemia.
Anemia, Diamond-Blackfan
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Anemia, Hemolytic
A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (Arg 107 --> Stop, CGA --> TGA) associated with chronic haemolytic anaemia.
Anemia, Hemolytic
A new variant of adenylate kinase (delG138) associated with severe hemolytic anemia.
Anemia, Hemolytic
AMP promotes oxygen consumption and ATP synthesis in heart mitochondria through the adenylate kinase reaction: an NMR spectroscopy and polarography study.
Anemia, Hemolytic
Congenital haemolytic anaemia associated with adenylate kinase deficiency.
Anemia, Hemolytic
Elevated erythrocyte CDP-choline levels associated with beta-thalassaemia in patients with transfusion independent anaemia.
Anemia, Hemolytic
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Hereditary disorders of erythrocyte enzymes in non-glycolytic metabolic pathways.
Anemia, Hemolytic
Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.
Anemia, Hemolytic
Metabolic compensation for profound erythrocyte adenylate kinase deficiency. A hereditary enzyme defect without hemolytic anemia.
Anemia, Hemolytic
Rare hereditary nonspherocytic hemolytic anemia caused by a novel homozygous mutation, c.301C?>?A, (Q101K), in the AK1 gene in an Indian family.
Anemia, Hemolytic
Red cell adenylate kinase deficiency associated with hereditary nonspherocytic hemolytic anemia: clinical and biochemical studies.
Anemia, Hemolytic
Red cell adenylate kinase deficiency in India: identification of two novel missense mutations (c.71A>G and c.413G>A).
Anemia, Hemolytic
Red cell adenylate kinase deficiency: molecular study of 3 new mutations (118G>A, 190G>A, and GAC deletion) associated with hereditary nonspherocytic hemolytic anemia.
Anemia, Hemolytic
Severe erythrocyte adenylate kinase deficiency due to homozygous A-->G substitution at codon 164 of human AK1 gene associated with chronic haemolytic anaemia.
Anemia, Hemolytic
Splenectomy resolves hemolytic anemia caused by adenylate kinase deficiency.
Anemia, Hemolytic
[A new erythroenzymopathy: congenital non-spherocytic hemolytic anemia and hereditary erythrocytic adenylate kinase deficiency]
Anemia, Hemolytic, Congenital
Molecular aspects of erythroenzymopathies associated with hereditary hemolytic anemia.
Anemia, Hemolytic, Congenital
Red cell adenylate kinase deficiency associated with hereditary nonspherocytic hemolytic anemia: clinical and biochemical studies.
Anemia, Hemolytic, Congenital Nonspherocytic
Rare hereditary nonspherocytic hemolytic anemia caused by a novel homozygous mutation, c.301C?>?A, (Q101K), in the AK1 gene in an Indian family.
Anemia, Macrocytic
Acute myeloblastic leukemia following non-Hodgkin lymphoma in an adolescent. A report of a case with preleukemic syndrome, and review of the literature.
Anemia, Refractory
[Enzyme deficiencies of blood cells in bone marrow insufficiency (author's transl]
Aortic Valve Stenosis
Reduction of four-and-a-half LIM-protein 2 expression occurs in human left ventricular failure and leads to altered localization and reduced activity of metabolic enzymes.
Arterial Occlusive Diseases
Assessment of muscular metabolism in peripheral arterial occlusive disease using 31P nuclear magnetic resonance spectroscopy. Comparison with metabolite concentrations in femoral blood.
Atherosclerosis
Extracellular Purine Metabolism in Blood Vessels (Part II): Activity of Ecto-Enzymes in Blood Vessels of Patients With Abdominal Aortic Aneurysm.
Bacterial Infections
Caffeine supplementation in diet mitigates Aeromonas hydrophila-induced impairment of the gill phosphotransfer network in grass carp Ctenopharyngodon idella.
Bacterial Infections
Involvement of the phosphoryl transfer network on cardiac energetic metabolism during Staphylococcus aureus infection and its association to disease pathophysiology.
Bacterial Infections
Phosphotransferase systems in Enterococcus faecalis OG1RF enhance anti-stress capacity in vitro and in vivo.
Brain Edema
Adenylate kinase, amino acids, and other substances in cerebrospinal fluid as markers either for recent cerebral infarction or for concomitant cerebral edema.
Brain Ischemia
MR and cerebrospinal fluid enzymes as sensitive indicators of subclinical cerebral injury after open-heart valve replacement surgery.
Brain Neoplasms
Adenylate kinase activity and glutathione concentration of cerebrospinal fluid in different neurological disorders.
Brain Neoplasms
Malignant brain tumours associated with adenylate kinase in cerebrospinal fluid.
Breast Neoplasms
Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.
Burkitt Lymphoma
Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues.
Carcinogenesis
HCV NS4B targets Scribble for proteasome-mediated degradation to facilitate cell transformation.
Carcinogenesis
Prognostic and therapeutic potential of Adenylate kinase 2 in lung adenocarcinoma.
Carcinogenesis
Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression.
Carcinogenesis
[Influence of thymostimulin on the activity of certain enzymes of adenosine and AMP metabolism in lymphocytes of rats with mammary cancer]
Carcinoma
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Carcinoma
Adenylate kinase masquerading as mitochondrial creatine kinase in a patient with carcinoma of the uterus.
Carcinoma
Effects of estradiol and tamoxifen on creatine kinase in rodent mammary carcinomas.
Carcinoma, Embryonal
Increase of adenylate kinase isozyme 1 protein during neuronal differentiation in mouse embryonal carcinoma P19 cells and in rat brain primary cultured cells.
Carcinoma, Hepatocellular
Adenosine triphosphate: adenosine monophosphate phosphotransferase isozymes in rat liver and hepatomas.
Carcinoma, Hepatocellular
Efficient packaging of a specific VL30 retroelement by psi 2 cells which produce MoMLV recombinant retroviruses.
Carcinoma, Hepatocellular
Elevated carbohydrate phosphotransferase activity in human hepatoma and phosphorylation of cathepsin D.
Carcinoma, Hepatocellular
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Carcinoma, Hepatocellular
Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses.
Carcinoma, Hepatocellular
Photosensitization of mitochondrial adenosine-triphosphatase and adenylate kinase by hematoporphyrin derivative in vitro.
Carcinoma, Hepatocellular
Prostaglandin regulation of adenylate kinases purifed from liver, skeletal muscle, and hepatoma.
Carcinoma, Hepatocellular
Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5'-phosphate derivatives.
Carcinoma, Hepatocellular
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Carcinoma, Hepatocellular
[Carbohydrate phosphotransferase in human hepatoma and phosphorylation of cathepsin D]
Carcinoma, Squamous Cell
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Central Nervous System Diseases
Adenylate kinase activity of cerebrospinal fluid in central nervous system disorders.
Cerebral Infarction
Adenylate kinase activity and glutathione concentration of cerebrospinal fluid in different neurological disorders.
Cerebral Infarction
Adenylate kinase, amino acids, and other substances in cerebrospinal fluid as markers either for recent cerebral infarction or for concomitant cerebral edema.
Cerebral Infarction
CSF cyclic AMP and CSF adenylate kinase in cerebral ischaemic infarction.
Cerebral Infarction
Ischemic edema in stroke. A parallel study with computed tomography and cerebrospinal fluid markers of disturbed brain cell metabolism.
Cerebral Infarction
Perspectives of adenylate kinase activity and glutathione concentration in cerebrospinal fluid of patients with ischemic and neoplastic brain lesions.
Cerebrovascular Disorders
Adenylate kinase activity and glutathione concentration of cerebrospinal fluid in different neurological disorders.
Chagas Disease
An expanded adenylate kinase gene family in the protozoan parasite Trypanosoma cruzi.
Cholera
Cra and cAMP Receptor Protein Have Opposing Roles in the Regulation of fruB in Vibrio cholerae.
Ciliary Motility Disorders
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia.
Ciliary Motility Disorders
Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype.
Ciliary Motility Disorders
New adenylate kinase 7 (AK7) mutation in primary ciliary dyskinesia.
Ciliary Motility Disorders
Role of adenylate kinase type 7 expression on cilia motility: possible link in primary ciliary dyskinesia.
Ciliopathies
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module.
Coccidiosis
Intestinal injury caused by Eimeria spp. impairs the phosphotransfer network and gain weight in experimentally infected chicken chicks.
Colitis
Enterococcus faecalis Gluconate Phosphotransferase System Accelerates Experimental Colitis and Bacterial Killing by Macrophages.
Colonic Neoplasms
Differential cyclin-dependent kinase expression and activation in human colon cancer.
Colorectal Neoplasms
Activation and dramatically increased cytolytic activity of tumor specific T lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases.
Colorectal Neoplasms
Activation of tumor-specific T lymphocytes after laser-induced thermotherapy in patients with colorectal liver metastases.
Colorectal Neoplasms
Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.
Colorectal Neoplasms
An in situ study of bioenergetic properties of human colorectal cancer: the regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome.
Colorectal Neoplasms
Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation.
Communicable Diseases
Listeria monocytogenes impairs enzymes of the phosphotransfer network and alters antioxidant/oxidant status in cattle brain structures.
Contracture
Myoadenylate deaminase deficiency and malignant hyperthermia susceptibility: is there a relationship?
Cystic Fibrosis
A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.
Cystic Fibrosis
A recombinant polypeptide model of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator functions as an active ATPase, GTPase and adenylate kinase.
Cystic Fibrosis
ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.
Cystic Fibrosis
ATP and AMP Mutually Influence Their Interaction with the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) at Separate Binding Sites.
Cystic Fibrosis
Inhibition of ATPase, GTPase and adenylate kinase activities of the second nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator by genistein.
Cystic Fibrosis
Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia.
Cystic Fibrosis
Nucleotide-binding Domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but Not ATP Hydrolysis.
Cystic Fibrosis
P2Z-Independent and P2Z receptor-mediated macrophage killing by Pseudomonas aeruginosa isolated from cystic fibrosis patients.
Cystinosis
Cysteamine prevents inhibition of adenylate kinase caused by cystine in rat brain cortex.
Cytomegalovirus Infections
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene.
Deafness
AMP promotes oxygen consumption and ATP synthesis in heart mitochondria through the adenylate kinase reaction: an NMR spectroscopy and polarography study.
Deafness
Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness.
Deafness
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis.
Dehydration
Methyl-CpG-Binding Domain Protein MBD7 Is Required for Active DNA Demethylation in Arabidopsis.
Dehydration
Photosynthesis, water use, and root viability under water stress as affected by expression of SAG12-ipt controlling cytokinin synthesis in Agrostis stolonifera.
Dehydration
Water content, adenylate kinase, and mitochondria drive adenylate balance in dehydrating and imbibing seeds.
Dengue
A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication.
Dengue
Computer-aided analysis of phytochemicals as potential dengue virus inhibitors based on molecular docking, ADMET and DFT studies.
Dengue
Maturation of dengue virus nonstructural protein 4B in monocytes enhances production of dengue hemorrhagic fever-associated chemokines and cytokines.
Dengue
Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication.
Dental Caries
A Membrane-Targeted Peptide Inhibiting PtxA of Phosphotransferase System Blocks Streptococcus mutans.
Dental Caries
Vesicles prepared from Streptococcus mutans demonstrate the presence of a second glucose transport system.
Dentofacial Deformities
Adverse effects on the brain in connection with isoflurane-induced hypotensive anaesthesia.
Dermatomyositis
[Determination of myokinase and creatine phosphokinase in serum in experimental lathyrism, dermatomyositis and progessive scleroderma]
Diabetes Mellitus, Type 2
A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
A study of adenylate kinase locus 1 (ak 1 ) genetic polymorphism in diabetic pregnancy.
Diabetes Mellitus, Type 2
Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.
Diabetic Retinopathy
Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy.
Diabetic Retinopathy
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.
Dupuytren Contracture
A comparative study of the activity of lysosomal and main metabolic pathway enzymes in tissue biopsies and cultured fibroblasts from Dupuytren's disease and palmar fascia. On the pathobiochemistry of connective tissue proliferation, I.
Dystonia
Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis.
Endocarditis
Genome-wide screening identifies PTS permease BepA to be involved in Enterococcus faecium endocarditis and biofilm formation.
Epilepsy
Down-regulation of adenylate kinase 5 in temporal lobe epilepsy patients and rat model.
Epilepsy
Dynamic Expression of Adenylate Kinase 2 in the Hippocampus of Pilocarpine Model Rats.
Epilepsy, Temporal Lobe
Down-regulation of adenylate kinase 5 in temporal lobe epilepsy patients and rat model.
Epilepsy, Temporal Lobe
Dynamic Expression of Adenylate Kinase 2 in the Hippocampus of Pilocarpine Model Rats.
Fetal Growth Retardation
Human fetal growth retardation. 3. Protein, DNA, RNA, adenine nucleotides and activities of the enzymes pyruvic and adenylate kinase in placenta.
Focal Dermal Hypoplasia
Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?
fructose-bisphosphate aldolase deficiency
Red cell enzymopathies as a model of inborn errors of metabolism.
Genetic Diseases, Inborn
Human adenylate kinase deficiency associated with hemolytic anemia. A single base substitution affecting solubility and catalytic activity of the cytosolic adenylate kinase.
Glioma
A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.
Glioma
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
A simple screening procedure for adenylate kinase, hexokinase and glucose-6-phosphate dehydrogenase deficiencies.
glucose-6-phosphate dehydrogenase (nadp+) deficiency
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
glucose-6-phosphate isomerase deficiency
Enzymatic diagnosis in non-spherocytic hemolytic anemia.
glucose-6-phosphate isomerase deficiency
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Glucosephosphate Dehydrogenase Deficiency
A simple screening procedure for adenylate kinase, hexokinase and glucose-6-phosphate dehydrogenase deficiencies.
Glucosephosphate Dehydrogenase Deficiency
Red cell enzyme deficiencies in the tribal population groups of the Bastar District, Madhya Pradesh, India.
Glycogen Storage Disease
Genetic evidence for the common identity of glucose-6-phosphatase, pyrophosphate-glucose phosphotransferase, carbamyl phosphate-glucose phosphotransferase and inorganic pyrophosphatase.
Glycogen Storage Disease Type V
Normal activities of AMP-deaminase and adenylate kinase in patients with McArdle disease.
Graft vs Host Disease
Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft.
Heart Failure
Adenylate kinase-catalyzed phosphotransfer in the myocardium : increased contribution in heart failure.
Heart Failure
High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes.
Heart Failure
Reduction of four-and-a-half LIM-protein 2 expression occurs in human left ventricular failure and leads to altered localization and reduced activity of metabolic enzymes.
Heart Septal Defects, Atrial
Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery.
Hepatitis B
Prediction of transmembrane segments in proteins utilising multiple sequence alignments.
Hepatitis C
A genetic interaction between hepatitis C virus NS4B and NS3 is important for RNA replication.
Hepatitis C
Aminoterminal amphipathic ?-helix AH1 of hepatitis C virus nonstructural protein 4B possesses a dual role in RNA replication and virus production.
Hepatitis C
Amphipathic {alpha}-Helix AH2 is a Major Determinant for the Oligomerization of Hepatitis C Virus Nonstructural Protein 4B.
Hepatitis C
An amphipathic alpha-helix at the C terminus of hepatitis C virus nonstructural protein 4B mediates membrane association.
Hepatitis C
Analysis of hepatitis C virus resistance to silibinin in vitro and in vivo points to a novel mechanism involving nonstructural protein 4B.
Hepatitis C
Biochemical characterization of recombinant hepatitis C virus nonstructural protein 4B: evidence for ATP/GTP hydrolysis and adenylate kinase activity.
Hepatitis C
Cell-free expression, purification, and membrane reconstitution for NMR studies of the nonstructural protein 4B from hepatitis C virus.
Hepatitis C
Conserved GXXXG- and S/T-like motifs in the transmembrane domains of NS4B protein are required for hepatitis C virus replication.
Hepatitis C
Dimerization of the hepatitis C virus nonstructural protein 4B depends on the integrity of an aminoterminal basic leucine zipper.
Hepatitis C
Direct targeting of proteins to lipid droplets demonstrated by time-lapse live cell imaging.
Hepatitis C
Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/?-catenin pathway.
Hepatitis C
Gene expression profiles of HeLa Cells impacted by hepatitis C virus non-structural protein NS4B.
Hepatitis C
Glycine Zipper Motifs in Hepatitis C Virus Nonstructural Protein 4B Are Required for the Establishment of Viral Replication Organelles.
Hepatitis C
HCV NS4B targets Scribble for proteasome-mediated degradation to facilitate cell transformation.
Hepatitis C
Hepatitis C virus nonstructural protein 4B: a journey into unexplored territory.
Hepatitis C
Hepatitis C virus NS4B induces unfolded protein response and endoplasmic reticulum overload response-dependent NF-kappaB activation.
Hepatitis C
Identification of a Novel Determinant for Membrane Association in Hepatitis C Virus Nonstructural Protein 4B.
Hepatitis C
Identification of the nonstructural protein 4B of hepatitis C virus as a factor that inhibits the antiviral activity of interferon-alpha.
Hepatitis C
Modulation of hepatitis C virus genome encapsidation by nonstructural protein 4B.
Hepatitis C
Modulation of replication efficacy of the hepatitis C virus replicon Con1 by site-directed mutagenesis of an NS4B aminoterminal basic leucine zipper.
Hepatitis C
The hepatitis C virus nonstructural protein 4B is an integral endoplasmic reticulum membrane protein.
Hepatitis C
The predominant species of nonstructural protein 4B in hepatitis C virus-replicating cells is not palmitoylated.
Hepatitis C
[Screening of differentially expressed genes and gene pathways in hepatitis C virus 1b type nonstructural protein 4B stably expressed L02 cell line].
Hepatitis C, Chronic
[Screening of differentially expressed genes and gene pathways in hepatitis C virus 1b type nonstructural protein 4B stably expressed L02 cell line].
Herpes Simplex
Adenosine diphosphate: thymidine 5'-phosphotransferase, a new enzyme activity, associated with the Herpes simplex virus-induced deoxypyrimidine kinase.
Herpes Simplex
Deletions within the HSV-tk transgene in long-lasting circulating gene-modified T cells infused with a hematopoietic graft.
Herpes Simplex
Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes.
Herpes Simplex
Inducible expression of herpes simplex virus thymidine kinase from a bicistronic HIV1 vector.
Herpes Simplex
Locating a nucleotide-binding site in the thymidine kinase of vaccinia virus and of herpes simplex virus by scoring triply aligned protein sequences.
Herpes Simplex
Nucleotide sequence of the thymidine kinase gene of herpes simplex virus type 1.
Herpes Simplex
The construction of cosmid libraries which can be used to transform eukaryotic cells.
Herpes Zoster
Novel proteomic profiling of epididymal extracellular vesicles in the domestic cat reveals proteins related to sequential sperm maturation with differences observed between normospermic and teratospermic individuals.
Hydrocephalus, Normal Pressure
Dementia--and adenylate kinase activity in cerebrospinal fluid.
Hyperglycemia
Adenylate kinase activity in various organs and tissues of mice with the obese-hyperglycemic syndrome (gene symbol Ob/Ob).
Hypertension
Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies.
Hyperthyroidism
[Action of detergents on G-6-P phosphohydrolase, pyrophosphatase and PPi-glucose phosphotransferase in the liver of hyperthyroid rats]
Hypotension
Adverse effects on the brain in connection with isoflurane-induced hypotensive anaesthesia.
Hypotension
Occurrence of adenylate kinase in cerebrospinal fluid after isoflurane anaesthesia and orthognathic surgery.
Hypotension
[Brain damage caused by hypotensive anesthesia? Both the anesthetic technique and the anesthetic agent must be chosen with care]
Infections
Adaptation of a 2D in-gel kinase assay to trace phosphotransferase activities in the human pathogen Leishmania donovani.
Infections
Adenylate kinase of Escherichia coli, a component of the phage T4 dNTP synthetase complex.
Infections
Bacteriophage T7 protein kinase: Site of inhibitory autophosphorylation, and use of dephosphorylated enzyme for efficient modification of protein in vitro.
Infections
Detection of somatic coliphages through a bioluminescence assay measuring phage mediated release of adenylate kinase and adenosine 5'-triphosphate.
Infections
Expression of the neomycin-resistance (neo) gene induces alterations in gene expression and metabolism.
Infections
Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection.
Infections
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Infections
Influence of phage population on the phage-mediated bioluminescent adenylate kinase (AK) assay for detection of bacteria.
Infections
Intestinal injury caused by Eimeria spp. impairs the phosphotransfer network and gain weight in experimentally infected chicken chicks.
Infections
Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors.
Infections
Phosphotransferase System Uptake and Metabolism of the ?-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection.
Infections
Recurrent and persistent cytomegalovirus infection in a kidney recipient caused by the L595S mutation in UL97 phosphotransferase gene.
Infections
The Phosphocarrier Protein HPr Contributes to Meningococcal Survival during Infection.
Infections
The phosphoenolpyruvate phosphotransferase system in group A Streptococcus acts to reduce streptolysin S activity and lesion severity during soft tissue infection.
Infections
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Infections
YjbH mediates the oxidative stress response and infection by regulating SpxA1 and the phosphoenolpyruvate-carbohydrate phosphotransferase system (PTS) in Listeria monocytogenes.
Infertility, Male
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia.
Influenza, Human
Mapping and nucleotide sequence of the vaccinia virus gene that encodes a 14-kilodalton fusion protein.
Intellectual Disability
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia.
Intracranial Arteriosclerosis
Drug action on adenylate kinase activity in cerebrospinal fluid of arteriosclerotic patients.
Intracranial Arteriosclerosis
Effect of cardiac glycosides on the release of adenylate kinase into cerebrospinal fluid of patients with cerebral arteriosclerosis.
Kidney Failure, Chronic
Energy production, intracellular amino acid pools, and protein synthesis in chronic renal disease.
Kidney Neoplasms
Combined cryoablation and GM-CSF treatment for metastatic hormone refractory prostate cancer.
Kidney Neoplasms
Immunologic response to primary cryoablation of high-risk prostate cancer.
Legionnaires' Disease
Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila.
Leigh Disease
Diagnosis and treatment in a case of juvenile subacute necrotizing encephalopathy Leigh without cytochrome c oxidase deficiency.
Leprosy
Genetic markers and leprosy in South African negroes: Part II. Erythrocyte enzyme polymorphisms.
Leukemia
Disruption of genes regulated during hematopoietic differentiation of mouse embryonic stem cells.
Leukemia
Lithium inhibits hepatic gluconeogenesis and phosphoenolpyruvate carboxykinase gene expression.
Leukemia
Monocyte chemoattractant protein-1 (MCP-1) gene transduction: an effective tumor vaccine strategy for non-intracranial tumors.
Leukemia
Vanadate inhibits expression of the gene for phosphoenolpyruvate carboxykinase (GTP) in rat hepatoma cells.
Leukemia
WEHI-3B D+ Y1 leukemia cells as a model system to assess the induction of differentiation in vivo.
Leukemia, Lymphocytic, Chronic, B-Cell
Acute myeloblastic leukemia following non-Hodgkin lymphoma in an adolescent. A report of a case with preleukemic syndrome, and review of the literature.
Leukemia, Lymphocytic, Chronic, B-Cell
Enzymological studies in chronic lymphocytic leukemia.
Leukemia, Myeloid, Acute
High expression of AK1 predicts inferior prognosis in acute myeloid leukemia patients undergoing chemotherapy.
Limbic Encephalitis
Adenylate kinase 5 autoimmunity in treatment refractory limbic encephalitis.
Limbic Encephalitis
Characteristics in limbic encephalitis with anti-adenylate kinase 5 autoantibodies.
Limbic Encephalitis
Clinico-pathological correlation in adenylate kinase 5 autoimmune limbic encephalitis.
Limbic Encephalitis
Distinctive clinical presentation and pathogenic specificities of anti-AK5 encephalitis.
Limbic Encephalitis
Identification of adenylate kinase 5 antibodies during routine diagnostics in a tissue-based assay: Three new cases and a review of the literature.
Lupus Erythematosus, Systemic
Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.
Lupus Erythematosus, Systemic
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production.
Lymphoma
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Lymphoma
Regulation of BCR- and PKC/Ca(2+)-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities.
Lymphoma
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
Lymphoma, B-Cell
Evidence of altered depression and dementia-related proteins in the brains of young rats after ovariectomy.
Lymphoma, Non-Hodgkin
Protein phosphotransferase activities and cyclic nucleotide action in proliferating lymphocytes.
Lysosomal Storage Diseases
Mucolipidosis III type C: first-trimester biochemical and molecular prenatal diagnosis.
Meningioma
Adenylate kinase activity and glutathione concentration of cerebrospinal fluid in different neurological disorders.
Meningism
Cerebrospinal fluid content of adenylate kinase, lactate and glutathione in patients with meningitis.
Meningitis
Adenylate kinase activity in the cerebrospinal fluid of children with tuberculous meningitis and its relationship to neurological outcome.
Meningitis
Cerebrospinal fluid content of adenylate kinase, lactate and glutathione in patients with meningitis.
Meningitis, Bacterial
Cerebrospinal fluid content of adenylate kinase, lactate and glutathione in patients with meningitis.
Meningoencephalitis
Studies of biochemical markers in cerebrospinal fluid in patients with meningoencephalitis.
Mouth Neoplasms
Metabolomic analysis of human oral cancer cells with adenylate kinase 2 or phosphorylate glycerol kinase 1 inhibition.
Mucolipidoses
Cholesterol esterification and Niemann-Pick disease: an approach to identifying the defect in fibroblasts.
Mucolipidoses
Identification of mutations in the GNPTA (MGC4170) gene coding for GlcNAc-phosphotransferase alpha/beta subunits in Korean patients with mucolipidosis type II or type IIIA.
Mucolipidoses
Mucolipidosis III type C: first-trimester biochemical and molecular prenatal diagnosis.
Mucolipidoses
Properties of N-acetylglucosamine 1-phosphotransferase from human lymphoblasts.
Mucolipidoses
The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin.
Multiple Sclerosis
Adenylate kinase activity and glutathione concentration of cerebrospinal fluid in different neurological disorders.
Muscular Dystrophies
An aberrant adenylate kinase isoenzyme from the serum of patients with Duchenne muscular dystrophy.
Muscular Dystrophies
Comparison of adenylate kinase from liver and muscle of normal mice and those with an hereditary muscular dystrophy.
Muscular Dystrophies
Structure and function of adenylate kinase isozymes in normal humans and muscular dystrophy patients.
Muscular Dystrophies
[Activity of myokinase (adenylate kinase) and creatine kinase in serum and muscles in Erb's progressive muscular dystrophy]
Muscular Dystrophy, Duchenne
An aberrant adenylate kinase isoenzyme from the serum of patients with Duchenne muscular dystrophy.
Muscular Dystrophy, Duchenne
Erythrocyte enzyme allotypes in the X-linked recessive disorders, Duchenne muscular dystrophy and haemophilia-A hemizygotes and heterozygotes.
Muscular Dystrophy, Duchenne
Structure and function of adenylate kinase isozymes in normal humans and muscular dystrophy patients.
Myocardial Infarction
Adenylate kinase in human tissue. II. Serum adenylate kinase and myocardial infarction.
Myocardial Infarction
Resveratrol protects left ventricle by increasing adenylate kinase and isocitrate dehydrogenase activities in rats with myocardial infarction.
Myocardial Infarction
Serum adenylate kinase activity in the early phase of acute myocardial infarction.
Myocardial Infarction
Urinary adenylate kinase isoenzyme pattern in patients with myocardial infarction.
Myocardial Infarction
[Determination of myokinase (MK) of plasma in enzymologic diagnosis of myocardial infarct]
Myocardial Infarction
[The enzymatic diagnosis of myocardial infarction. II. Determination of organ-specific enzymes: creatine phosphokinase and myokinase]
Myocardial Ischemia
[Functional changes in the mitochondrial site of adenylate kinase and creatine kinase systems of energy transport induced by myocardial ischemia and adriablastin]
Nail-Patella Syndrome
Evidence for the assignment of the loci AK1, AK3 and ACONs to chromosome 9 in man.
Nail-Patella Syndrome
Linkage of the loci for the nail-patella syndrome and adenylate kinase.
Neoplasm Metastasis
Glyceraldehyde-3-phosphate dehydrogenase and Nm23-H1/nucleoside diphosphate kinase A. Two old enzymes combine for the novel Nm23 protein phosphotransferase function.
Neoplasm Metastasis
Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis.
Neoplasms
A differential proteome in tumors suppressed by an adenovirus-based skin patch vaccine encoding human carcinoembryonic antigen.
Neoplasms
Activation of a tumor-associated protein kinase (p40TAK) and casein kinase 2 in human squamous cell carcinomas and adenocarcinomas of the lung.
Neoplasms
AMP promotes oxygen consumption and ATP synthesis in heart mitochondria through the adenylate kinase reaction: an NMR spectroscopy and polarography study.
Neoplasms
Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells.
Neoplasms
Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.
Neoplasms
Biochemical studies on mitochondria isolated from Normal and Neoplastic Tissues of the Mouse Mammary Gland.
Neoplasms
Effects of estradiol and tamoxifen on creatine kinase in rodent mammary carcinomas.
Neoplasms
Energy Metabolic Plasticity of Colorectal Cancer Cells as a Determinant of Tumor Growth and Metastasis.
Neoplasms
Enzyme deviation patterns in primary rat hepatomas induced by sequential administration of two chemically different carcinogens.
Neoplasms
Enzyme pathology and the histologic categorization of human lung tumors: the continuum of quantitative biochemical indices of neoplasticity.
Neoplasms
Human coilin interacting nuclear ATPase protein in cancer: uncovering new insights into pathogenesis and therapy.
Neoplasms
Identification, assay, and purification of a Cdc2-activating threonine-161 protein kinase from human cells.
Neoplasms
Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid.
Neoplasms
KIT protein expression and analysis of c-kit gene mutation in adenoid cystic carcinoma.
Neoplasms
Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis.
Neoplasms
Photosensitization of mitochondrial adenosine-triphosphatase and adenylate kinase by hematoporphyrin derivative in vitro.
Neoplasms
Proteomic Analysis of Cervical Cancer Cells Treated with Adenovirus-Mediated MDA-7.
Neoplasms
Sequence analysis of a 45-kb segment in the 19 degrees-23 degrees region of the Bacillus subtilis chromosome containing glpT and mpr loci.
Neoplasms
Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells.
Neoplasms
UDP-N-acetylglucosamine: lysosomal enzyme precursor N-acetylglucosamine-1-phosphate transferase activities in human ovarian tumor tissue and some transformed cell lines.
Neoplasms
Unique structural features of the adenylate kinase hCINAP/AK6 and its multifaceted functions in carcinogenesis and tumor progression.
Nervous System Diseases
Adenylate kinase activity and glutathione concentration of cerebrospinal fluid in different neurological disorders.
Nervous System Diseases
Adenylate kinase activity of cerebrospinal fluid in central nervous system disorders.
Neuroblastoma
Further Evidence on Mitochondrial Targeting of ?-Amyloid and Specificity of ?-Amyloid-Induced Mitotoxicity in Neurons.
Neuroblastoma
Induction and quantitation of the RI cAMP-binding protein in clonal mouse neuroblastoma cell lines: evidence that the increase in RI is not linked to neurite outgrowth.
Neuroblastoma
Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.
Neurodegenerative Diseases
Amyloid-? peptide absence in short term effects on kinase activity of energy metabolism in mice hippocampus and cerebral cortex.
Neurofibromatoses
Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene.
Neurofibromatosis 1
Characterization of human adenylate kinase 3 (AK3) cDNA and mapping of the AK3 pseudogene to an intron of the NF1 gene.
nucleoside-diphosphate kinase deficiency
Adenylate kinase complements nucleoside diphosphate kinase deficiency in nucleotide metabolism.
Osteosarcoma
Varicella-zoster virus thymidine kinase gene and antiherpetic pyrimidine nucleoside analogues in a combined gene/chemotherapy treatment for cancer.
Ovarian Neoplasms
Adenylate kinase 7 is a prognostic indicator of overall survival in ovarian cancer.
Ovarian Neoplasms
Protein kinase C delta is activated in mouse ovarian surface epithelial cancer cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
Parkinson Disease
The role of the MAGUK protein CASK in neural development and synaptic function.
Periodontal Diseases
Dysbiosis and alterations in predicted functions of the subgingival microbiome in chronic periodontitis.
phosphoglycerate kinase deficiency
Red cell enzymopathies as a model of inborn errors of metabolism.
Photosensitivity Disorders
Photosensitization of mitochondrial adenosine-triphosphatase and adenylate kinase by hematoporphyrin derivative in vitro.
Photosensitivity Disorders
Photosensitizing effects of Photofrin II on the site-selected mitochondrial enzymes adenylate kinase and monoamine oxidase.
Placental Insufficiency
Vascular placental insufficiency in the rabbit. Changes in creatine kinase and adenylate kinase activities in fetal tissues.
Plasmacytoma
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
Pneumonia
Streptococcus pneumoniae Cell-Wall-Localized Phosphoenolpyruvate Protein Phosphotransferase Can Function as an Adhesin: Identification of Its Host Target Molecules and Evaluation of Its Potential as a Vaccine.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Adenylate kinase 2 expression and addiction in T-ALL.
Prostatic Neoplasms
Adenylate kinase: an oncodevelopmental marker in an animal model for human prostatic cancer.
Prostatic Neoplasms
Combined cryoablation and GM-CSF treatment for metastatic hormone refractory prostate cancer.
Prostatic Neoplasms
Identity of phosphotransferase and phosphomonoesterase of human prostate and of sera from patients with prostatic cancer.
Prostatic Neoplasms
Immunologic response to primary cryoablation of high-risk prostate cancer.
Psoriasis
Deciphering Gut Microbiota Dysbiosis and Corresponding Genetic and Metabolic Dysregulation in Psoriasis Patients Using Metagenomics Sequencing.
Psychomotor Disorders
A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (Arg 107 --> Stop, CGA --> TGA) associated with chronic haemolytic anaemia.
Psychomotor Disorders
Erythrocyte adenylate kinase deficiency: characterization of recombinant mutant forms and relationship with nonspherocytic hemolytic anemia.
pyruvate kinase deficiency
Study of pathophysiology and molecular characterization of congenital anemia in India using targeted next-generation sequencing approach.
Retinal Detachment
Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy.
Retinal Perforations
Deregulation of ocular nucleotide homeostasis in patients with diabetic retinopathy.
Retinal Perforations
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.
Retinoblastoma
17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.
Rhabdomyosarcoma
Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues.
Sarcoma
Adenosine triphosphate-guanosine 5'-phosphate phosphotransferase. II. Inhibition by 6-thioguanosine 5'-phosphate of the enzyme isolated from hog brain and sarcoma 180 ascites cells.
Sarcoma
Adenosine triphosphate-guanosine 5'-phosphate phosphotransferase. IV. Isozymes in human erythrocytes and Sarcoma 180 ascites cells.
Sarcoma
ADP effects on bleomycin-induced DNA repair synthesis and adenylate kinase activity in permeable mouse sarcoma cells.
Sarcoma
pp60v-src tyrosine kinase is expressed and active in sarcoma-free avian embryos microinjected with Rous sarcoma virus.
Sarcoma
The same normal cell protein is phosphorylated after transformation by avian sarcoma viruses with unrelated transforming genes.
Sarcoma
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma 180
Adenosine triphosphate-guanosine 5'-phosphate phosphotransferase. II. Inhibition by 6-thioguanosine 5'-phosphate of the enzyme isolated from hog brain and sarcoma 180 ascites cells.
Sarcoma 180
Adenosine triphosphate-guanosine 5'-phosphate phosphotransferase. IV. Isozymes in human erythrocytes and Sarcoma 180 ascites cells.
Sarcoma, Avian
Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins.
Sarcoma, Avian
Increase in the phosphotransferase specific activity of purified Rous sarcoma virus pp60v-src protein after incubation with ATP plus Mg2+.
Sarcoma, Avian
The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo.
Sarcoma, Avian
The same normal cell protein is phosphorylated after transformation by avian sarcoma viruses with unrelated transforming genes.
Schistosomiasis japonica
Immunization with recombinant schistosome adenylate kinase 1 partially protects mice against Schistosoma japonicum infection.
Sepsis
Influence of a beta-adrenergic agonist on septic shock-induced alterations of phosphatidylcholine metabolism in rat lung.
Sepsis
Influence of a?-adrenergic agonist on septic shock-induced alterations of phosphatidylcholine metabolism in rat lung.
Severe Combined Immunodeficiency
Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.
Soft Tissue Infections
Phosphotransferase System Uptake and Metabolism of the ?-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection.
Soft Tissue Infections
The phosphoenolpyruvate phosphotransferase system in group A Streptococcus acts to reduce streptolysin S activity and lesion severity during soft tissue infection.
Starvation
Cell cycle control and environmental response by second messengers in Caulobacter crescentus.
Starvation
Effect of polyamines on plasmid-mediated kanamycin resistance and kanamycin phosphotransferase gene expression in Escherichia coli.
Starvation
Regulation of nitrogenase synthesis in histidine auxotrophs of Klebsiella pneumoniae with altered levels of adenylate nucleotides.
Starvation
The phosphotransferase protein EIIA(Ntr) modulates the phosphate starvation response through interaction with histidine kinase PhoR in Escherichia coli.
Starvation
Thiolutin inhibits utilization of glucose and other carbon sources in cells of Escherichia coli.
Stroke
Cerebrospinal fluid markers of disturbed brain cell metabolism in patients with stroke and global cerebral ischemia.
Stroke
Ischemic edema in stroke. A parallel study with computed tomography and cerebrospinal fluid markers of disturbed brain cell metabolism.
Teratocarcinoma
Creatine kinase, myokinase, and acetylcholinesterase activities in muscle-forming primary cultures of mouse teratocarcinoma cells.
Triple Negative Breast Neoplasms
Changes of EGFR and SMC4 expressions in triple-negative breast cancer and their early diagnostic value.
Tuberculosis
1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase.
Tuberculosis
Adenylate kinase: a novel antigen for immunodiagnosis and subunit vaccine against tuberculosis.
Tuberculosis
Elucidation of Mg²? binding activity of adenylate kinase from Mycobacterium tuberculosis H??Rv using fluorescence studies.
Tuberculosis
Lcp1 Is a Phosphotransferase Responsible for Ligating Arabinogalactan to Peptidoglycan in Mycobacterium tuberculosis.
Tuberculosis
Nucleoside diphosphate kinase-like activity in adenylate kinase of Mycobacterium tuberculosis.
Tuberculosis
Purification of polyphosphate and ATP glucose phosphotransferase from Mycobacterium tuberculosis H37Ra: evidence that poly(P) and ATP glucokinase activities are catalyzed by the same enzyme.
Tuberculosis
Rv3168 phosphotransferase activity mediates kanamycin resistance in Mycobacterium tuberculosis.
Tuberculosis
Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity.
Tuberculosis
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
Tuberculosis, Meningeal
Adenylate kinase activity in the cerebrospinal fluid of children with tuberculous meningitis and its relationship to neurological outcome.
Tuberous Sclerosis
Serum and tissue proteins in tuberous sclerosis. I. Serum and red-cell polymorphic systems.
Vaccinia
Locating a nucleotide-binding site in the thymidine kinase of vaccinia virus and of herpes simplex virus by scoring triply aligned protein sequences.
Virus Diseases
A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication.
Virus Diseases
Enzymatic Properties and Physiological Roles of Cytosolic 5'-Nucleotidase II.
Vitreous Hemorrhage
Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage.
Whooping Cough
Structural and physico-chemical characteristics of Bordetella pertussis adenylate kinase, a tryptophan-containing enzyme.
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). SMC_PYRFU
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
1177
0
135014
Swiss-Prot
-
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
crystal structure of the nucleotide-binding domain of the Pyrococcus furiosus structural maintenance of chromosome protein (pfSMCnbd) in complex with the adenylate kinase inhibitor P1,P5-di(adenosine-5')pentaphosphate
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Lammens, A.; Hopfner, K.
Structural basis for adenylate kinase activity in ABC ATPases
J. Mol. Biol.
401
265-273
2010
Pyrococcus furiosus (Q8TZY2), Pyrococcus furiosus
brenda
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Release 2023.1 (January 2023)
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