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Information on EC 2.7.11.11 - cAMP-dependent protein kinase
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2.7.11.11 cAMP-dependent protein kinaseIUBMB Comments
This eukaryotic enzyme recognizes the sequence -Arg-Arg-X-Ser*/Thr*-Hpo, where * indicates the phosphorylated residue and Hpo indicates a hydrophobic residue.The inactive holoenzyme is a heterotetramer composed of two regulatory (R) subunits and two catalytic (C) subunits. Each R subunit occludes the active site of a C subunit and contains two binding sites for 3',5'-cyclic-AMP (cAMP). Binding of cAMP activates the enzyme by causing conformational changes that release two free monomeric C subunits from a dimer of the R subunits, i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C. Activity requires phosphorylation of a conserved Thr in the activation loop (T-loop) sequence (Thr198 in human Calpha; Thr224 in budding yeast Tpk2), installed by auto-phosphorylation or by the 3-phosphoinositide-dependent protein kinase-1 (PDPK1). Certain R2C2 combinations can be localized to particular subcellular regions by their association with diverse species of 'A Kinase-Anchoring Proteins' (AKAPs). The enzyme has been characterized from many organisms. Humans have three C units (Calpha, Cbeta, and Cgamma) encoded by the paralogous genes PRKACA, PRKACB and PRKACG, respectively, and four R subunits (R1alpha, RIbeta, RIIalpha and RIIbeta), encoded by PKRAR1A, PKRAR1B, PKRAR2A and PKRAR2B, respectively. Yeast (Saccharomyces cerevisiae) has three C subunits (Tpk1, Tpk2, and Tpk3) encoded by the paralogous genes TPK1, TPK2 and TPK3, respectively, and a single R subunit (Bcy1) encoded by the BCY1 gene. Some validated substrates of the enzyme include cAMP-response element-binding protein (CREB), phosphorylase kinase alpha subunit (PHKA), and tyrosine 3-monooxygenase (TH) in mammals; Adr1, Whi3, Nej1, and Pyk1 in yeast.
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Word Map
- 2.7.11.11
- cyclase
- forskolin
- agonist
- adenylate
- phosphodiesterase
- cardiac
-
adenylyl
- phosphoprotein
- isoproterenol
- synaptic
-
holoenzyme
- cgmp
-
phorbol
-
dibutyryl
- a-kinase
- prostaglandin
- calmodulin
-
cgmp-dependent
-
beta-adrenergic
- creb
- phosphopeptide
-
desensitization
-
akaps
- autophosphorylation
-
camp-mediated
-
gamma-32patp
- pki
- rp-camps
-
pka-dependent
-
camp-responsive
-
sarcoplasmic
-
l-type
- phospholamban
-
8-br-camp
- 8-bromo-camp
-
calmodulin-dependent
-
pka-mediated
-
camp-independent
-
patch-clamp
- 3',5'-monophosphate
- ibmx
-
camp-induced
- 3-isobutyl-1-methylxanthine
- isoprenaline
-
camp-regulated
-
camp-stimulated
- dibutyryl-camp
-
phosphorylatable
- rolipram
-
phospholipid-dependent
- medicine
- drug development
The expected taxonomic range for this enzyme is: Eukaryota, Archaea, Bacteria
Reaction Schemes
+
a [protein]-(L-serine/L-threonine)
=
+
a [protein]-(L-serine/L-threonine) phosphate
Synonyms
camp-dependent protein kinase, a kinase, cyclic amp-dependent protein kinase, camp-pka, camp/protein kinase a, capk, prkaca, camp dependent protein kinase, camp-dependent pka, cyclic amp-dependent protein kinase a, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
A kinase
-
-
-
-
ATP:protein phosphotransferase (cAMP-dependent)
-
-
-
-
cAMP-dependent protein kinase
-
-
-
-
PK-25
-
-
-
-
PKA
-
-
-
-
PKA C-alpha
-
-
-
-
PKA C-beta
-
-
-
-
PKA C-gamma
-
-
-
-
PKA catalytic (C) subunit
-
-
-
-
protein kinase A
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
ATP:protein Ser/Thr-phosphotransferase (3',5'-cAMP-dependent)
This eukaryotic enzyme recognizes the sequence -Arg-Arg-X-Ser*/Thr*-Hpo, where * indicates the phosphorylated residue and Hpo indicates a hydrophobic residue.The inactive holoenzyme is a heterotetramer composed of two regulatory (R) subunits and two catalytic (C) subunits. Each R subunit occludes the active site of a C subunit and contains two binding sites for 3',5'-cyclic-AMP (cAMP). Binding of cAMP activates the enzyme by causing conformational changes that release two free monomeric C subunits from a dimer of the R subunits, i.e. R2C2 + 4 cAMP = R2(cAMP)4 + 2 C. Activity requires phosphorylation of a conserved Thr in the activation loop (T-loop) sequence (Thr198 in human Calpha; Thr224 in budding yeast Tpk2), installed by auto-phosphorylation or by the 3-phosphoinositide-dependent protein kinase-1 (PDPK1). Certain R2C2 combinations can be localized to particular subcellular regions by their association with diverse species of 'A Kinase-Anchoring Proteins' (AKAPs). The enzyme has been characterized from many organisms. Humans have three C units (Calpha, Cbeta, and Cgamma) encoded by the paralogous genes PRKACA, PRKACB and PRKACG, respectively, and four R subunits (R1alpha, RIbeta, RIIalpha and RIIbeta), encoded by PKRAR1A, PKRAR1B, PKRAR2A and PKRAR2B, respectively. Yeast (Saccharomyces cerevisiae) has three C subunits (Tpk1, Tpk2, and Tpk3) encoded by the paralogous genes TPK1, TPK2 and TPK3, respectively, and a single R subunit (Bcy1) encoded by the BCY1 gene. Some validated substrates of the enzyme include cAMP-response element-binding protein (CREB), phosphorylase kinase alpha subunit (PHKA), and tyrosine 3-monooxygenase (TH) in mammals; Adr1, Whi3, Nej1, and Pyk1 in yeast.
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CAS REGISTRY NUMBER
COMMENTARY
142008-29-5
-
142008-29-5
cAMP-dependent protein kinase
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + SP20 protein
ADP + phosphorylated SP20 protein
i.e. TTYADFIASGRTGRRASIHD
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + SP20 protein
ADP + phosphorylated SP20 protein
i.e. TTYADFIASGRTGRRASIHD
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Acidosis
Effect of metabolic acidosis on renal response to parathyroid hormone in phosphorus-deprived rats.
Acidosis
Effect of pH on lipolysis, cAMP and cAMP-dependent protein kinase activity in isolated rat fat cells.
Acquired Immunodeficiency Syndrome
Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells.
ACTH-Secreting Pituitary Adenoma
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
Adenocarcinoma
CRH inhibits cell growth of human endometrial adenocarcinoma cells via CRH-receptor 1-mediated activation of cAMP-PKA pathway.
Adenocarcinoma
Differential expression of cAMP-kinase subunits is correlated with growth in rat mammary carcinomas and uterus.
Adenocarcinoma
Inhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2.
Adenocarcinoma
Parallel activation of cyclic AMP phosphodiesterase and cyclic AMP-dependent protein kinase in two human gut adenocarcinoma cells (HT 29 and HRT 18) in culture, by vasoactive intestinal peptide (VIP) and other effectors activating the cyclic AMP system.
Adenocarcinoma
Protein kinase A activation of the surfactant protein B gene is mediated by phosphorylation of thyroid transcription factor 1.
Adenocarcinoma
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Adenocarcinoma of Lung
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Adenocarcinoma, Follicular
Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis.
Adenoma
Clinical characteristics of PRKACA mutations in Chinese patients with adrenal lesions: a single-centre study.
Adenoma
Functional changes in the regulatory subunit of the type II cyclic adenosine 3':5'-monophosphate-dependent protein kinase isozyme during normal and neoplastic lung development.
Adenoma
Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.
Adenoma
GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24.
Adenoma
Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss.
Adenoma
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Adenoma
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Adenoma
Human GHRH reduces voltage-gated K+ currents via a non-cAMP-dependent but PKC-mediated pathway in human GH adenoma cells.
Adenoma
Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.
Adenoma
Lipofuscin Accumulation in Cortisol-Producing Adenomas With and Without PRKACA Mutations.
Adenoma
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Adenoma
PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia - a single-center study of 60 cases.
Adenoma
RNA-Sequencing and Somatic Mutation Status of Adrenocortical Tumors: Novel Pathogenetic Insights.
Adenoma
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
Adenoma
Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.
Adrenocortical Adenoma
5th International ACC Symposium: The New Genetics of Benign Adrenocortical Neoplasia: Hyperplasias, Adenomas, and Their Implications for Progression into Cancer.
Adrenocortical Adenoma
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Adrenocortical Adenoma
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Adrenocortical Adenoma
Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
Adrenocortical Adenoma
Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.
Adrenocortical Adenoma
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
Adrenocortical Adenoma
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
Adrenocortical Adenoma
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Adrenocortical Adenoma
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Adrenocortical Adenoma
PKA C? subunit mutation triggers caspase-dependent RII? subunit degradation via Ser114 phosphorylation.
Adrenocortical Adenoma
PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.
Adrenocortical Adenoma
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
Adrenocortical Adenoma
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Adrenocortical Carcinoma
Cisplatin resistance and regulation of DNA repair in cAMP-dependent protein kinase mutants.
Adrenocortical Carcinoma
Cisplatin sensitivity in cAMP-dependent protein kinase mutants of Saccharomyces cerevisiae.
Adrenocortical Carcinoma
Clinical characteristics of PRKACA mutations in Chinese patients with adrenal lesions: a single-centre study.
Adrenocortical Carcinoma
Partial purification and characterization of the defective cyclic adenosine 3':5'-monophosphate binding protein kinase from adrenocortical carcinoma.
Adrenocortical Carcinoma
Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.
Albinism, Oculocutaneous
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
Alcohol Withdrawal Seizures
Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.
Alkalosis
Effect of pH on lipolysis, cAMP and cAMP-dependent protein kinase activity in isolated rat fat cells.
Alzheimer Disease
A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein.
Alzheimer Disease
A quantitative autoradiographic study of [3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits.
Alzheimer Disease
cAMP-dependent protein kinase in cerebral microvessels in aging and Alzheimer disease.
Alzheimer Disease
cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.
Alzheimer Disease
Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer's disease.
Alzheimer Disease
Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5.
Alzheimer Disease
Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain.
Alzheimer Disease
Hyperphosphorylation of human TAU by brain kinase PK40erk beyond phosphorylation by cAMP-dependent PKA: relation to Alzheimer's disease.
Alzheimer Disease
Impaired G-protein-stimulated adenylyl cyclase activity in Alzheimer's disease brain is not accompanied by reduced cyclic-AMP-dependent protein kinase A activity.
Alzheimer Disease
Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration.
Alzheimer Disease
Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale.
Alzheimer Disease
Phosphorylation of tau protein by purified p34cdc28 and a related protein kinase from neurofilaments.
Alzheimer Disease
Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.
Alzheimer Disease
Regional localization of the regulatory subunit (RII beta) of the type II cAMP-dependent protein kinase in human brain.
Alzheimer Disease
Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions.
Alzheimer Disease
Tau protein kinase II is involved in the regulation of the normal phosphorylation state of tau protein.
Anthrax
Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A (PKA) and exchange protein activated by cAMP (Epac) pathways.
Arrhythmias, Cardiac
Activation of protein kinase A modulates trafficking of the human cardiac sodium channel in Xenopus oocytes.
Asthma
?2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.
Asthma
Calcitonin Gene-Related Peptide and Cyclic Adenosine 5'-Monophosphate/Protein Kinase A Pathway Promote IL-9 Production in Th9 Differentiation Process.
Astrocytoma
An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.
Astrocytoma
Association of Aurora A and gamma-tubulin expression in astrocytomas and patient survival.
Astrocytoma
Induction of peptidylarginine deiminase 2 and 3 by dibutyryl cAMP via cAMP-PKA signaling in human astrocytoma U-251MG cells.
Astrocytoma
Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.
Astrocytoma
Thrombin produces phosphorylation of cytosolic phospholipase A2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell line 1321N1.
Ataxia
Effect of ovarian hormones on survival genes in laser captured serotonin neurons from macaques.
Ataxia
Microcephalin: a causal link between impaired damage response signalling and microcephaly.
Ataxia
Sustained antagonism of acute ethanol-induced ataxia following microinfusion of cyclic AMP and cpt-cAMP in the mouse cerebellum.
Ataxia Telangiectasia
Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis.
Ataxia Telangiectasia
ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells.
Ataxia Telangiectasia
ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage.
Ataxia Telangiectasia
Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling.
Ataxia Telangiectasia
Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in mice.
Ataxia Telangiectasia
Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA.
Ataxia Telangiectasia
Human cytomegalovirus glycoprotein B variants affect viral entry, cell fusion, and genome stability.
Ataxia Telangiectasia
Human syndromes with genomic instability and multiprotein machines that repair DNA double-strand breaks.
Ataxia Telangiectasia
Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells.
Ataxia Telangiectasia
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
Atherosclerosis
Intermedin Ameliorates Atherosclerosis by Increasing Cholesterol Efflux Through the cAMP-PKA Pathway in Macrophage RAW264.7 Cell Line.
Autoimmune Diseases
Design and Synthesis of New JAK1 Inhibitors based on SulfonamideTriazine Conjugates.
Autoimmune Diseases
Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery.
Blister
The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.
Bone Neoplasms
Activation of the cAMP-PKA signaling pathway in rat dorsal root ganglion and spinal cord contributes toward induction and maintenance of bone cancer pain.
Bone Neoplasms
Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury.
Bone Neoplasms
Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord.
Bone Resorption
cAMP-PKA signaling pathway regulates bone resorption mediated by processing of cathepsin K in cultured mouse osteoclasts.
Bone Resorption
Differential effects of the 3',5'-cyclic adenosine monophosphate and protein kinase C pathways on the response of isolated rat osteoclasts to calcitonin.
Bone Resorption
Role of dual signal transduction systems in the stimulation of bone resorption by parathyroid hormone-related peptide. The direct involvement of cAMP-dependent protein kinase.
Bone Resorption
The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone.
Bradycardia
5-HT(4) receptors in nucleus tractus solitarii attenuate cardiopulmonary reflex in anesthetized rats.
Brain Diseases
Aminoglycoside drugs induce efficient read-through of CDKL5 nonsense mutations, slightly restoring its kinase activity.
Brain Injuries, Traumatic
Age-dependent alterations in cAMP signaling contribute to synaptic plasticity deficits following traumatic brain injury.
Brain Ischemia
A novel voltage-sensitive Na(+) and Ca(2+) channel blocker, NS-7, prevents suppression of cyclic AMP-dependent protein kinase and reduces infarct area in the acute phase of cerebral ischemia in rat.
Brain Ischemia
Alteration of second messengers during acute cerebral ischemia - adenylate cyclase, cyclic AMP-dependent protein kinase, and cyclic AMP response element binding protein.
Brain Ischemia
Delayed activation and regulation of MKK7 in hippocampal CA1 region following global cerebral ischemia in rats.
Brain Ischemia
Impairment of cerebral cAMP-mediated signal transduction system and of spatial memory function after microsphere embolism in rats.
Brain Ischemia
Inhibition of cyclic AMP-dependent protein kinase in the acute phase of focal cerebral ischemia in the rat.
Brain Neoplasms
Gain of HIF1 Activity and Loss of miRNA let-7d Promote Breast Cancer Metastasis to the Brain via the PDGF/PDGFR Axis.
Brain Neoplasms
Phosphorylation of pyruvate kinase type K in human gliomas by a cyclic adenosine 5'-monophosphate-independent protein kinase.
Breast Neoplasms
A kinase inhibitor screen identifies Mcl-1 and Aurora kinase A as novel treatment targets in antiestrogen-resistant breast cancer cells.
Breast Neoplasms
A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells.
Breast Neoplasms
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Breast Neoplasms
Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?
Breast Neoplasms
Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.
Breast Neoplasms
Characteristics of selective activation of cyclic AMP-dependent protein kinase isoenzymes by calcitonin and prostaglandin E2 in human breast cancer cells.
Breast Neoplasms
Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.
Breast Neoplasms
Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
Breast Neoplasms
Differential regulation of ErbB2 expression by cAMP-dependent protein kinase in tamoxifen-resistant breast cancer cells.
Breast Neoplasms
Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer.
Breast Neoplasms
Down-regulation of type I protein kinase A by transfection of human breast cancer cells with an epidermal growth factor receptor antisense expression vector.
Breast Neoplasms
ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.
Breast Neoplasms
Identification of protein kinase inhibitors to reprogram breast cancer cells.
Breast Neoplasms
IL-24 Promotes Apoptosis through cAMP-Dependent PKA Pathways in Human Breast Cancer Cells.
Breast Neoplasms
Inorganic polyphosphate stimulates mammalian TOR, a kinase involved in the proliferation of mammary cancer cells.
Breast Neoplasms
Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth.
Breast Neoplasms
Involvement of the cAMP/protein kinase A pathway and of mitogen-activated protein kinase in the anti-proliferative effects of anandamide in human breast cancer cells.
Breast Neoplasms
Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells.
Breast Neoplasms
Mitotic apparatus and nucleoli compartmentalization of 50,000-dalton type II regulatory subunit of cAMP-dependent protein kinase in estrogen receptor negative MDA-MB-231 human breast cancer cells.
Breast Neoplasms
Nucleolar accumulation of cyclic adenosine 3':5'-monophosphate receptor proteins during regression of MCF-7 human breast tumor.
Breast Neoplasms
Osteoclast precursors acquire sensitivity to breast cancer derived factors early in differentiation.
Breast Neoplasms
Overexpression of AKIP1 predicts poor prognosis of patients with breast carcinoma and promotes cancer metastasis through Akt/GSK-3?/Snail pathway.
Breast Neoplasms
Phase I trial to evaluate the addition of alisertib to fulvestrant in women with endocrine-resistant, ER+ metastatic breast cancer.
Breast Neoplasms
PHLDA1 is a crucial negative regulator and effector of Aurora A kinase in breast cancer.
Breast Neoplasms
PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.
Breast Neoplasms
Quantitation of cellular phosphorylation dynamics by phosphoproteomics approaches.
Breast Neoplasms
Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase.
Breast Neoplasms
Regulation of multidrug resistance through the cAMP and EGF signalling pathways.
Breast Neoplasms
Salicylate suppresses the oncogenic hyaluronan network in metastatic breast cancer cells.
Breast Neoplasms
SGK3 sustains ER? signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis.
Breast Neoplasms
SRC drives growth of antiestrogen resistant breast cancer cell lines and is a marker for reduced benefit of tamoxifen treatment.
Breast Neoplasms
Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.
Breast Neoplasms
The biphasic induction of p21 and p27 in breast cancer cells by modulators of cAMP is posttranscriptionally regulated and independent of the PKA pathway.
Breast Neoplasms
The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.
Breast Neoplasms
The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth.
Breast Neoplasms
The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers.
Breast Neoplasms
WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance.
Brucellosis
Subversion and utilization of the host cell cyclic adenosine 5'-monophosphate/protein kinase A pathway by Brucella during macrophage infection.
camp-dependent protein kinase deficiency
cAMP and protein kinase A in endocrine (and other) tumors.
camp-dependent protein kinase deficiency
Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes.
camp-dependent protein kinase deficiency
High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.
camp-dependent protein kinase deficiency
Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production.
Carcinogenesis
An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.
Carcinogenesis
Anticarcinogenic effect of N6,O2'-dibutyryl cyclic adenosine 3':5'-monophosphate on 7,12-dimethylbenz(a)anthracene mammary tumor induction in the rat and its relationship to cyclic adenosine 3':5'-monophosphate metabolism and protein kinase.
Carcinogenesis
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.
Carcinogenesis
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Carcinogenesis
Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.
Carcinogenesis
Biology of Aurora A kinase: Implications in cancer manifestation and therapy.
Carcinogenesis
Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine.
Carcinogenesis
CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
Carcinogenesis
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Carcinogenesis
Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase.
Carcinogenesis
Effect of gastrin on gastric mucosal cyclic adenosine 3':5'-monophosphate-dependent protein kinase activity in rat stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis
Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
Carcinogenesis
Identification of a clinically homogenous subgroup of benign cortisol-secreting adrenocortical tumors characterized by alterations of the protein kinase A (PKA) subunits and high PKA activity.
Carcinogenesis
Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.
Carcinogenesis
Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.
Carcinogenesis
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Carcinogenesis
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.
Carcinogenesis
Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.
Carcinogenesis
Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis.
Carcinogenesis
Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop.
Carcinogenesis
PRKACA: the catalytic subunit of protein kinase A and adrenocortical tumors.
Carcinogenesis
Prostaglandin E2 stimulates normal bronchial epithelial cell growth through induction of c-Jun and PDK1, a kinase implicated in oncogenesis.
Carcinogenesis
Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
Carcinogenesis
Response to MLN8237 in pancreatic cancer is not dependent on RalA phosphorylation.
Carcinogenesis
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression.
Carcinogenesis
[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]
Carcinoma
Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.
Carcinoma
Calcium-activated, phospholipid-dependent protein kinase in human gastric mucosa and carcinoma.
Carcinoma
Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter.
Carcinoma
Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.
Carcinoma
Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.
Carcinoma
Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.
Carcinoma
Cross-activation: overriding cAMP/cGMP selectivities of protein kinases in tissues.
Carcinoma
Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.
Carcinoma
Down-regulation of PLK3 gene expression by types and amount of dietary fat in rat colon tumors.
Carcinoma
Effects of marine sponge extracts on mitogen-activated protein kinase (MAPK/ERK(1,2)) activity in SW-13 human adrenal carcinoma cells.
Carcinoma
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Carcinoma
Expression of a mutant regulatory subunit of cAMP-dependent protein kinase in the Caco-2 human colonic carcinoma cell line.
Carcinoma
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Carcinoma
Hepatic adenomas with synchronous or metachronous fibrolamellar carcinomas: both are characterized by LFABP loss.
Carcinoma
Human VRK2 (vaccinia-related kinase 2) modulates tumor cell invasion by hyperactivation of NFAT1 and expression of cyclooxygenase-2.
Carcinoma
Overexpression of RII beta regulatory subunit of protein kinase A in human colon carcinoma cell induces growth arrest and phenotypic changes that are abolished by site-directed mutation of RII beta.
Carcinoma
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
Carcinoma
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.
Carcinoma
Redundant regulation of urokinase plasminogen activator transcription by the two major isozymes of cAMP-dependent protein kinase.
Carcinoma
Regulation of P-glycoprotein expression in cyclic AMP-dependent protein kinase mutants.
Carcinoma
Subcellular distribution of the R-subunits of cAMP-dependent protein kinase in LS-174T human colon carcinoma cells.
Carcinoma
The isozyme pattern of cyclic AMP-dependent protein kinase and the distribution of a cervicovaginal antigen in experimental carcinoma of the cervix uteri of mice.
Carcinoma
Tumorigenesis suppressor pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.
Carcinoma
Two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas.
Carcinoma
Type I and II cyclic adenosine 3':5'-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas.
Carcinoma
Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.
Carcinoma
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Carcinoma, Ehrlich Tumor
Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
Carcinoma, Ehrlich Tumor
The in vitro effects of glycyrrhizin and the derivatives of glycyrrhetinic acid on the activity of cAMP-dependent protein kinase and phosphorylation of cellular polypeptide by the kinase from Ehrlich ascites tumor cells.
Carcinoma, Embryonal
Effect of retinoic acid treatment of F9 embryonal carcinoma cells on the activity and distribution of cyclic AMP-dependent protein kinase.
Carcinoma, Hepatocellular
2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
A novel anti-cancer substance, MK615, from ume, a variety of Japanese apricot, inhibits growth of hepatocellular carcinoma cells by suppressing Aurora A kinase activity.
Carcinoma, Hepatocellular
A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish.
Carcinoma, Hepatocellular
A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma.
Carcinoma, Hepatocellular
A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.
Carcinoma, Hepatocellular
Beta-adrenergic receptors and angiotensinogen gene expression in mouse hepatoma cells in vitro.
Carcinoma, Hepatocellular
Cloning and expression in Escherichia coli of a rat hepatoma cell cDNA coding for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Carcinoma, Hepatocellular
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.
Carcinoma, Hepatocellular
Cytochemical identification of the regulatory subunit of the cAMP-dependent protein kinase by use of fluorescently labeled catalytic subunit. Examination of protein kinase dissociation in hepatoma cells responding to 8-Br-cAMP stimulation.
Carcinoma, Hepatocellular
Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Direct cytochemical localization of catalytic subunits dissociated from cAMP-dependent protein kinase in Reuber H-35 hepatoma cells. I. Development and validation of fluorescinated inhibitor.
Carcinoma, Hepatocellular
Direct cytochemical localization of catalytic subunits dissociated from cAMP-dependent protein kinase in Reuber H-35 hepatoma cells. II. Temporal and spatial kinetics.
Carcinoma, Hepatocellular
Direct evidence that the protein kinase catalytic subunit mediates the effects of cAMP on tyrosine aminotransferase synthesis.
Carcinoma, Hepatocellular
Focal adhesion kinase (FAK) regulates insulin-stimulated glycogen synthesis in hepatocytes.
Carcinoma, Hepatocellular
HIP/PAP, a C-type lectin overexpressed in hepatocellular carcinoma, binds the RII alpha regulatory subunit of cAMP-dependent protein kinase and alters the cAMP-dependent protein kinase signalling.
Carcinoma, Hepatocellular
Identification of the ?-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells.
Carcinoma, Hepatocellular
Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma.
Carcinoma, Hepatocellular
In vivo footprinting of the carbamoylphosphate synthetase I cAMP-response unit indicates important roles for FoxA and PKA in formation of the enhanceosome.
Carcinoma, Hepatocellular
Induction of tyrosine aminotransferase in H-35 hepatoma cells by cAMP captured in phospholipid vesicles.
Carcinoma, Hepatocellular
Inhibition of hepatoma cell growth by analogs of adenosine and cyclic AMP and the influence of enzymes in mammalian sera.
Carcinoma, Hepatocellular
Insulin decreases H4IIE cell PEPCK mRNA by a mechanism that does not involve cAMP.
Carcinoma, Hepatocellular
Isolation and partial characterisation of insulin-mimetic inositol phosphoglycans from human liver.
Carcinoma, Hepatocellular
Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells.
Carcinoma, Hepatocellular
Kinase gene expression and subcellular protein expression pattern of protein kinase C isoforms in curcumin-treated human hepatocellular carcinoma Hep 3B cells.
Carcinoma, Hepatocellular
Localization of nuclear subunits of cyclic AMP-dependent protein kinase by the immunocolloidal gold method.
Carcinoma, Hepatocellular
MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated ?-catenin/ABCB1 signaling pathway.
Carcinoma, Hepatocellular
Modulation of nuclear cyclic AMP-dependent protein kinase in dibutyryl cyclic AMP-treated rat H4IIE hepatoma cells.
Carcinoma, Hepatocellular
Molecular testing for the clinical diagnosis of fibrolamellar carcinoma.
Carcinoma, Hepatocellular
Phosphorylation of beta-glucuronidases from human normal liver and hepatoma by cAMP-dependent protein kinase.
Carcinoma, Hepatocellular
PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
Carcinoma, Hepatocellular
Regulation of phosphoenolpyruvate carboxykinase gene transcription in H4IIE hepatoma cells: evidence for a primary role of the catalytic subunit of 3',5'-cyclic adenosine monophosphate-dependent protein kinase.
Carcinoma, Hepatocellular
Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
Carcinoma, Hepatocellular
Structural analyses of the PKA RII? holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
Structures of the PKA RI? Holoenzyme with the FLHCC Driver J-PKAc? or Wild-Type PKAc?.
Carcinoma, Hepatocellular
Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.
Carcinoma, Hepatocellular
[Cancer-associated alterations of human hepatocellular carcinoma beta-glucuronidase--study on phosphorylation by 3', 5'-cyclic AMP dependent-protein kinase]
Carcinoma, Hepatocellular
[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]
Carcinoma, Non-Small-Cell Lung
Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: Exposure-Response Analyses of Pivotal ALTA Study.
Carcinoma, Non-Small-Cell Lung
Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation.
Carcinoma, Non-Small-Cell Lung
Molecular Modeling, Docking, Dynamics and simulation of Gefitinib and its derivatives with EGFR in Non-Small Cell Lung Cancer.
Carcinoma, Non-Small-Cell Lung
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Carcinoma, Renal Cell
Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.
Carcinoma, Renal Cell
The serine proteinase thrombin promotes migration of human renal carcinoma cells by a PKA-dependent mechanism.
Carcinoma, Squamous Cell
cAMP-dependent protein kinase stimulates epidermal growth factor-dependent phosphorylation of epidermal growth factor receptors.
Carcinoma, Squamous Cell
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Carcinoma, Squamous Cell
Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [177Lu]Lu-PP-F11N.
Carcinoma, Squamous Cell
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.
Carcinoma, Squamous Cell
Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.
Carcinoma, Squamous Cell
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Cardiomegaly
Alterations in activities of cyclic nucleotide systems and in beta-adrenergic receptor-mediated activation of cyclic AMP-dependent protein kinase during progression and regression of isoproterenol-induced cardiac hypertrophy.
Cardiomegaly
Changes in cyclic AMP dependent protein kinase and active stiffness in the rat volume overload model of heart hypertrophy.
Cardiomegaly
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.
Cardiomegaly
Effect of endostatin overexpression on angiotensin II-induced cardiac hypertrophy in rats.
Cardiomegaly
Evidence for calreticulin attenuation of cardiac hypertrophy induced by pressure overload and soluble agonists.
Cardiomyopathy, Dilated
Activation of cyclic AMP-dependent protein kinase in cardiomyocytes by anti-beta 1-adrenoceptor autoantibodies from patients with idiopathic dilated cardiomyopathy.
Cardiomyopathy, Dilated
Activity of cAMP-dependent protein kinase and Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human hearts.
Cardiomyopathy, Dilated
Alterations in cAMP-mediated signaling and their role in the pathophysiology of dilated cardiomyopathy.
Cardiomyopathy, Dilated
cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium.
Carney Complex
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Carney Complex
Carney complex: A familial lentiginosis predisposing to a variety of tumors.
Carney Complex
Case report of familial Carney complex due to novel frameshift mutation c.597del C (p.Phe200LeufsX6) in PRKAR1A.
Carney Complex
Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.
Carney Complex
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Carney Complex
Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
Carney Complex
Fibrolamellar Carcinoma in the Carney Complex: PRKAR1A Loss Instead of the Classic DNAJB1-PRKACA Fusion.
Carney Complex
GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24.
Carney Complex
How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
Carney Complex
Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.
Carney Complex
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and primary pigmented nodular adrenocortical disease (PPNAD) reveals novel mutations and clues for pathophysiology: augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.
Carney Complex
Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
Carney Complex
PRKAR1A Mutations and protein kinase A interactions with other signaling pathways in the adrenal cortex.
Carney Complex
Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
Cerebral Infarction
Protein kinase A-dependent suppression of reactive oxygen species in transient focal ischemia in adrenomedullin-deficient mice.
Cholangiocarcinoma
FGFR2 genomic aberrations: Achilles heel in the management of advanced cholangiocarcinoma.
Cholera
A crucial role for cAMP and protein kinase A in D1 dopamine receptor regulated intracellular calcium transients.
Cholera
Activation of locus coeruleus (LC) neurones by cholera toxin: mediation by cAMP-dependent protein kinase.
Cholera
Acute and chronic regulation of Na+/K+-ATPase transport activity in the RN22 Schwann cell line in response to stimulation of cyclic AMP production.
Cholera
Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase activity in rodent pituitary tissue: possible role in cAMP-dependent hormone secretion.
Cholera
Calcium-mediated transduction of the hormonal message in meiosis reinitiation of starfish oocytes: modulation following injection of cholera toxin and cAMP-dependent protein kinase.
Cholera
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Cholera
Cholera toxin treatment stimulates tumorigenicity of Rous sarcoma virus-transformed cells.
Cholera
Cholera toxin, and the related nontoxic adjuvants mmCT and dmLT, promote human Th17 responses via cyclic AMP-protein kinase A and inflammasome-dependent IL-1 signaling.
Cholera
Differential effects of activation of protein kinase C and cyclic-AMP-dependent protein kinase on sodium-dependent phosphate uptake in NIH 3T3 cells.
Cholera
Effect of ADP-ribosylation factor amino-terminal deletions on its GTP-dependent stimulation of cholera toxin activity.
Cholera
Effects of cholera toxin on thyroid cyclic AMP-dependent protein kinase and ornithine decarboxylase activities.
Cholera
Effects of cholinergic and adrenergic agonists on phosphorylation of a 165,000-dalton myofibrillar protein in intact cardiac muscle.
Cholera
Evidence of heterotrimeric G-protein involvement in regulated exocytosis from permeabilized pancreatic acini.
Cholera
Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.
Cholera
Influence of cholera toxin (an adenylate cyclase activator) on deoxyribonucleic acid synthesis of bovine mammary tissue in vitro and in athymic nude mice.
Cholera
Inhibition by the protein kinase inhibitors, isoquinolinesulfonamides, of fluid accumulation induced by Escherichia coli heat-stable enterotoxin, 8-bromo-cGMP and 8-bromo-cAMP in suckling mice.
Cholera
Inhibition of choriogonadotropin-activated steroidogenesis in cultured Leydig tumor cells by the Rp diastereoisomer of adenosine 3',5'-cyclic phosphorothioate.
Cholera
Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP.
Cholera
Modification of steroidogenesis in a mouse adrenal cell line (Y-1) transformed by simian adenovirus SA-7.
Cholera
Regulation of bradykinin receptor level by cholera toxin, pertussis toxin and forskolin in cultured human fibroblasts.
Cholera
Regulation of CTP:phosphocholine cytidylyltransferase activity and phosphorylation in rat hepatocytes: lack of effect of elevated cAMP levels.
Cholera
Relationship of phosphorylation and ADP-ribosylation using a synthetic peptide as a model substrate.
Cholera
The cAMP-dependent protein kinase A and protein kinase C-beta pathways synergistically interact to activate HIV-1 transcription in latently infected cells of monocyte/macrophage lineage.
Cholera
The effect of cyclic nucleotides and cholera toxin on in vivo and in vitro phosphorylation of small intestinal brush border membranes.
Cholera
The pure inhibitor of cAMP-dependent protein kinase initiates Xenopus laevis meiotic maturation. A 4-step scheme for meiotic maturation.
Cholera
The regulation of steroidogenesis is different in the two types of ovine luteal cells.
Cholera
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Cholera
[Modulation of calcium conductance of the somatic membrane of sensory neurons of the rat upon activation of the adenylate cyclase system]
Chondroma
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Chondrosarcoma
Phosphorylation of proteoglycans from human articular cartilage by a cAMP-dependent protein kinase.
Choriocarcinoma
Effects of 8-bromo-cAMP on expression of endocrine functions by cultured human trophoblast cells. Regulation of specific mRNAs.
Choriocarcinoma
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Choroidal Neovascularization
Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor.
Coinfection
Specific DNA binding and transactivation potential of recombinant, purified Stat5.
Colonic Neoplasms
Adenosine 3',5'-cyclic monophosphate dependent and independent protein kinase activities in 1,2-dimethylhydrazine induced rat colon cancer.
Colonic Neoplasms
ASF1A regulates H4Y72 phosphorylation and promotes autophagy in colon cancer cells via a kinase activity.
Colonic Neoplasms
BRAF screening as a low-cost effective strategy for simplifying HNPCC genetic testing.
Colonic Neoplasms
Expression of Concern: ASF1A regulates H4Y72 phosphorylation and promotes autophagy in colon cancer cells via a kinase activity.
Colonic Neoplasms
Inhibition of cyclin A kinase activity in E2F-1 chemogene therapy of colon cancer.
Colonic Neoplasms
Phosphorylation of ?-catenin at serine 663 regulates its transcriptional activity.
Colonic Neoplasms
Prostaglandin E2 Stimulates the beta-catenin/T cell factor-dependent transcription in colon cancer.
Colonic Neoplasms
Synergistic growth inhibition and induction of apoptosis by a novel mixed backbone antisense oligonucleotide targeting CRIPTO in combination with C225 anti-EGFR monoclonal antibody and 8-Cl-cAMP in human GEO colon cancer cells.
Colorectal Neoplasms
Antioxidant-induced nuclear translocation of CCAAT/enhancer-binding protein beta. A critical role for protein kinase A-mediated phosphorylation of Ser299.
Colorectal Neoplasms
Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.
Colorectal Neoplasms
Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.
Colorectal Neoplasms
Lessons from phase III clinical trials on anti-VEGF therapy for cancer.
Colorectal Neoplasms
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
Colorectal Neoplasms
Rapid determination of AKAP12 promoter methylation levels in peripheral blood using methylation-sensitive high resolution melting (MS-HRM) analysis: application in colorectal cancer.
Colorectal Neoplasms
Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
Colorectal Neoplasms
[Expression of cAMP-dependent protein kinase inhibitor beta in colorectal carcinoma and its clinical significance].
Craniocerebral Trauma
[The cAMP content and cAMP-dependent protein kinase activity in the brain of rabbits in the dynamics of moderate craniocerebral trauma]
Cryopyrin-Associated Periodic Syndromes
Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
Cushing Syndrome
A genetic and molecular update on adrenocortical causes of Cushing syndrome.
Cushing Syndrome
Activating Hotspot L205R Mutation in PRKACA and Adrenal Cushing's Syndrome.
Cushing Syndrome
Alterations in Protein Kinase A Substrate Specificity as a Potential Cause of Cushing Syndrome.
Cushing Syndrome
Cushing's syndrome and fetal features resurgence in adrenal cortex-specific Prkar1a knockout mice.
Cushing Syndrome
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Cushing Syndrome
Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.
Cushing Syndrome
Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations.
Cushing Syndrome
Germline PRKACA amplification leads to Cushing syndrome caused by 3 adrenocortical pathologic phenotypes.
Cushing Syndrome
Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.
Cushing Syndrome
Neuroendocrine cancer. An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics.
Cushing Syndrome
Novel somatic mutations in the catalytic subunit of the protein kinase A as a cause of adrenal Cushing's syndrome: a European multicentric study.
Cushing Syndrome
PKA C? subunit mutation triggers caspase-dependent RII? subunit degradation via Ser114 phosphorylation.
Cushing Syndrome
Recurrent somatic mutations underlie corticotropin-independent Cushing's syndrome.
Cushing Syndrome
Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
Cushing Syndrome
Somatic PRKACA mutations: association with transition from pituitary-dependent to adrenal-dependent Cushing's syndrome.
Cystic Fibrosis
A short segment of the R domain of cystic fibrosis transmembrane conductance regulator contains channel stimulatory and inhibitory activities that are separable by sequence modification.
Cystic Fibrosis
A single conductance pore for chloride ions formed by two cystic fibrosis transmembrane conductance regulator molecules.
Cystic Fibrosis
Abnormal subcellular localization of mutated CFTR protein in a cystic fibrosis epithelial cell line.
Cystic Fibrosis
Adenosine activates a2b receptors and enhances chloride secretion in kidney inner medullary collecting duct cells.
Cystic Fibrosis
Antisense oligodeoxynucleotides to the cystic fibrosis transmembrane conductance regulator inhibit cAMP-activated but not calcium-activated chloride currents.
Cystic Fibrosis
Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity.
Cystic Fibrosis
cAMP-dependent protein kinase-mediated phosphorylation of cystic fibrosis transmembrane conductance regulator residue Ser-753 and its role in channel activation.
Cystic Fibrosis
cAMP/protein kinase A activates cystic fibrosis transmembrane conductance regulator for ATP release from rat skeletal muscle during low pH or contractions.
Cystic Fibrosis
Characterization of the cAMP response element of the cystic fibrosis transmembrane conductance regulator gene promoter.
Cystic Fibrosis
Contribution of R domain phosphoserines to the function of CFTR studied in Fischer rat thyroid epithelia.
Cystic Fibrosis
Correction: cAMP/Protein Kinase A Activates Cystic Fibrosis Transmembrane Conductance Regulator for ATP Release from Rat Skeletal Muscle during Low pH or Contractions.
Cystic Fibrosis
Cyclic AMP-dependent protein kinase activation of cystic fibrosis transmembrane conductance regulator chloride channels in planar lipid bilayers.
Cystic Fibrosis
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium.
Cystic Fibrosis
Cyclic AMP-related and cation-affected human platelet chloride transport regulation.
Cystic Fibrosis
Early embryonic renal tubules of wild-type and polycystic kidney disease kidneys respond to cAMP stimulation with cystic fibrosis transmembrane conductance regulator/Na(+),K(+),2Cl(-) Co-transporter-dependent cystic dilation.
Cystic Fibrosis
Effects of mutations in cAMP-dependent protein kinase on chloride efflux in Caco-2 human colonic carcinoma cells.
Cystic Fibrosis
Efficient intracellular processing of the endogenous cystic fibrosis transmembrane conductance regulator in epithelial cell lines.
Cystic Fibrosis
Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.
Cystic Fibrosis
Function of the R domain in the cystic fibrosis transmembrane conductance regulator chloride channel.
Cystic Fibrosis
Localization of cystic fibrosis transmembrane conductance regulator signaling complexes in human salivary gland striated duct cells.
Cystic Fibrosis
Multiple endocytic signals in the C-terminal tail of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Mutation of potential phosphorylation sites in the recombinant R domain of the cystic fibrosis transmembrane conductance regulator has significant effects on domain conformation.
Cystic Fibrosis
Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator.
Cystic Fibrosis
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis.
Cystic Fibrosis
Phosphorylation-dependent block of cystic fibrosis transmembrane conductance regulator chloride channel by exogenous R domain protein.
Cystic Fibrosis
Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.
Cystic Fibrosis
Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.
Cystic Fibrosis
Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin.
Cystic Fibrosis
Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by negative charge in the R domain.
Cystic Fibrosis
Regulation of the ROMK channel: interaction of the ROMK with associate proteins.
Cystic Fibrosis
The formation of the cAMP/protein kinase A-dependent annexin 2 S100A10 complex with cystic fibrosis conductance regulator protein (CFTR) regulates CFTR channel function.
Cystic Fibrosis
Type II protein kinase A regulates CFTR in airway, pancreatic, and intestinal cells.
Cysticercosis
Immunodiagnosis of porcine cysticercosis: identification of candidate antigens through immunoproteomics.
Cysticercosis
TsPKA-r: a potential immunodiagnostic antigen for the detection of porcine cysticercosis.
Cysts
Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.
Dehydration
Second messenger and cAMP-dependent protein kinase responses to dehydration and anoxia stresses in frogs.
Dehydration
Stimulation of CFU-f formation by prostaglandin E(2) is mediated in part by its degradation product, prostaglandin A(2).
Dehydration
Stimulation of CFU-f formation by prostaglandin E2 is mediated in part by its degradation product, prostaglandin A2.
Dehydration
[Activity of cAMP-dependent protein kinases and cAMP-binding proteins from rat renal cytosol upon dehydration.]
Dementia
CDK5 knockdown prevents hippocampal degeneration and cognitive dysfunction produced by cerebral ischemia.
Dermatofibrosarcoma
A novel MAP3K7CL-ERG fusion in a molecularly confirmed case of dermatofibrosarcoma protuberans with fibrosarcomatous transformation.
Diabetes Mellitus
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 1
The role of taurine in the pathogenesis of the cardiomyopathy of insulin-dependent diabetes mellitus.
Diabetes Mellitus, Type 2
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Diabetes Mellitus, Type 2
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Diabetic Cardiomyopathies
Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats.
Down Syndrome
DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels.
Down Syndrome
Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A).
Down Syndrome
Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology.
Down Syndrome
Phosphorylation of amphiphysin I by minibrain kinase/dual-specificity tyrosine phosphorylation-regulated kinase, a kinase implicated in Down syndrome.
Down Syndrome
Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling.
Dyskinesias
Dopamine- and cAMP-regulated Phosphoprotein of 32-kDa (DARPP-32)-dependent Activation of Extracellular Signal-regulated Kinase (ERK) and Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling in Experimental Parkinsonism.
Dyspnea
Cytomegalovirus-induced Hemorrhagic Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) on Dasatinib as an Upfront Therapy.
Endometrial Neoplasms
PP2A and E3 ubiquitin ligase deficiencies: Seminal biological drivers in endometrial cancer.
Endometriosis
Mismatch repair system in endometriotic tissue and eutopic endometrium of unaffected women.
Epilepsy
Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics.
Epilepsy
From Cancer to Pain Target by Automated Selectivity Inversion of a Clinical Candidate.
Exanthema
Cytomegalovirus-induced Hemorrhagic Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) on Dasatinib as an Upfront Therapy.
Familial Mediterranean Fever
Fast diagnostic test for familial Mediterranean fever based on a kinase inhibitor.
Fanconi Anemia
Aurora A kinase is required for activation of the Fanconi anemia/BRCA pathway upon DNA damage.
Fibrosarcoma
?2-Adrenoceptor Agonists Promote ERK1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-driven Signaling Independently of ?-Arrestin 2.
Fibrosarcoma
E2F-1 has properties of a radiosensitizer and its regulation by cyclin A kinase is required for cell survival of fibrosarcoma cells lacking p53.
Folliculitis
Perforating Folliculitis in a Patient Treated With Nilotinib: A Further Evidence of C-kit Involvement.
Frontotemporal Lobar Degeneration
Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.
Gastrointestinal Stromal Tumors
Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.
Gastrointestinal Stromal Tumors
Pityriasis rubra pilaris-like reaction induced by imatinib.
Giant Cell Tumor of Tendon Sheath
Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.
Glaucoma
Activation of 5-HT1A Receptors Promotes Retinal Ganglion Cell Function by Inhibiting the cAMP-PKA Pathway to Modulate Presynaptic GABA Release in Chronic Glaucoma.
Glioblastoma
Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells.
Glioblastoma
Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma.
Glioblastoma
An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.
Glioblastoma
An autocrine ActivinB mechanism drives TGF?/Activin signaling in Group 3 medulloblastoma.
Glioblastoma
Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line.
Glioblastoma
The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells.
Glioma
Activation of death-associated protein kinase in human peritumoral tissue: A potential therapeutic target.
Glioma
beta Adrenergic receptor-mediated regulation of cyclic nucleotide phosphodiesterase in C6 glioma cells: vinblastine blockade of isoproterenol induction.
Glioma
Characterization of cyclic adenosine 3':5'-monophosphate-dependent protein kinase isozymes in normal and neoplastic fetal rat brain cells.
Glioma
Differential effects of two structurally related N6-substituted cAMP analogues on C6 glioma cells.
Glioma
Glucose deprivation affects the expression of genes encoding cAMP-activated protein kinase and related proteins in U87 glioma cells in ERN1 dependent manner.
Glioma
MicroRNA 335 Is Required for Differentiation of Malignant Glioma Cells Induced by Activation of cAMP/Protein Kinase A Pathway.
Glioma
Microsomal prostaglandin E synthase-1 regulates human glioma cell growth via prostaglandin E(2)-dependent activation of type II protein kinase A.
Glioma
Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma X glioma hybrid cells.
Glioma
Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation.
Glioma
Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.
Glioma
Selective distribution of protein kinase A regulatory subunit RII{alpha} in rodent gliomas.
Glioma
The type IV phosphodiesterase inhibitor rolipram induces expression of the cell cycle inhibitors p21(Cip1) and p27(Kip1), resulting in growth inhibition, increased differentiation, and subsequent apoptosis of malignant A-172 glioma cells.
Glioma
Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas.
Goiter
Properties of cyclic AMP-dependent protein kinase in normal and goitrous rat thyroid gland.
Goiter
TSH and DBC action on cAMP-dependent protein kinase activities in cell cultures of human non-toxic goiters.
Gray Platelet Syndrome
Abnormal cAMP-induced phosphorylation of rap 1 protein in grey platelet syndrome platelets.
Growth Hormone-Secreting Pituitary Adenoma
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Heart Arrest
Cyclic adenosine monophosphate-protein kinase A signal pathway may be involved in pulmonary aquaporin-5 expression in ischemia/reperfusion rats following deep hypothermia cardiac arrest.
Heart Failure
Apoptosis signal-regulating kinase 1 attenuates atrial natriuretic peptide secretion.
Heart Failure
cAMP concentrations, cAMP dependent protein kinase activity, and phospholamban in non-failing and failing myocardium.
Heart Failure
cAMP-dependent protein kinase A-stimulated sarcoplasmic reticulum function in heart failure.
Heart Failure
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Heart Failure
Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice.
Heart Failure
Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.
Heart Failure
Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach.
Hematologic Neoplasms
Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
Hematologic Neoplasms
Oxidative stress by targeted agents promotes cytotoxicity in hematological malignancies.
Hepatitis B
A kinase chaperones hepatitis B virus capsid assembly and captures capsid dynamics in vitro.
Hepatitis B
Expression of hepatitis B virus core and precore antigens in insect cells and characterization of a core-associated kinase activity.
Hepatitis C
Hepatitis C virus NS5A protein is phosphorylated in vitro by a stably bound protein kinase from HeLa cells and by cAMP-dependent protein kinase A-alpha catalytic subunit.
Hepatitis C
Identification and characterization of a histone binding site of the non-structural protein 3 of hepatitis C virus.
Hepatitis C
Non-structural protein 3 of hepatitis C virus inhibits phosphorylation mediated by cAMP-dependent protein kinase.
Hepatitis C
Nonstructural protein 3 of hepatitis C virus blocks the distribution of the free catalytic subunit of cyclic AMP-dependent protein kinase.
Hepatitis C
The inhibition of cAMP-dependent protein kinase by full-length hepatitis C virus NS3/4A complex is due to ATP hydrolysis.
Hepatitis C
The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly.
Hepatoblastoma
Cold-stimulated increase in a regulatory subunit of cAMP-dependent protein kinase in human hepatoblastoma cells.
Hepatoblastoma
Targeting Aurora A kinase with Alisertib (ALS) Induces Autophagy and Cell Cycle Arrest and Increases Chemosensitivity in Hepatoblastoma HepG2 Cells.
Herpes Simplex
Expression of the cyclic AMP-dependent protein kinase (PKA) catalytic subunit from a herpes simplex virus vector extends the survival of rat sympathetic neurons in the absence of NGF.
Herpes Simplex
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
Herpes Simplex
The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.
Herpes Zoster
Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
Herpes Zoster
N6-substituted cAMP Analogs Inhibit bTREK-1 K+ Channels and Stimulate Cortisol Secretion by a PKA-Independent Mechanism.
HIV Infections
Additive effects of IL-2 and protein kinase A type I antagonist on function of T cells from HIV-infected patients on HAART.
HIV Infections
Cytokine networks are pre-activated in T cells from HIV-infected patients on HAART and are under the control of cAMP.
HIV Infections
Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients.
Hyperaldosteronism
PRKACA Somatic Mutations Are Rare Findings in Aldosterone-Producing Adenomas.
Hyperalgesia
cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.
Hyperalgesia
cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain.
Hyperalgesia
Change in prostaglandin signaling during sickness syndrome hyperalgesia after ovariectomy in female rats.
Hyperalgesia
Chronic compression or acute dissociation of dorsal root ganglion induces cAMP-dependent neuronal hyperexcitability through activation of PAR2.
Hyperalgesia
Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1.
Hyperalgesia
Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors.
Hyperalgesia
Further confirmation of the role of adenyl cyclase and of cAMP-dependent protein kinase in primary afferent hyperalgesia.
Hyperalgesia
GRK6 acts as a critical regulator of cytokine-induced hyperalgesia by promoting PI3kinase- and inhibiting p38-signaling.
Hyperalgesia
Involvement of endogenous nitric oxide in the mechanism of bradykinin-induced peripheral hyperalgesia.
Hyperalgesia
Rapid, opioid-sensitive mechanisms involved in transient receptor potential vanilloid 1 sensitization.
Hyperalgesia
Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo.
Hyperglycemia
The Opening of ATP-Sensitive K+ Channels Protects H9c2 Cardiac Cells Against the High Glucose-Induced Injury and Inflammation by Inhibiting the ROS-TLR4-Necroptosis Pathway.
Hyperglycemia
The protective roles of GLP-1R signaling in diabetic nephropathy: possible mechanism and therapeutic potential.
Hyperhomocysteinemia
Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.
Hyperkalemia
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
Hyperpigmentation
cAMP-dependent PKA activation as a therapeutic target of skin hyperpigmentation by diphenylmethylene hydrazinecarbothioamide.
Hypersensitivity
A highly conserved tyrosine of Tim-3 is phosphorylated upon stimulation by its ligand galectin-9.
Hypersensitivity
Crosstalk between protein kinase A and the HOG pathway under impaired biosynthesis of complex sphingolipids in budding yeast.
Hypersensitivity
Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.
Hypersensitivity
Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation.
Hypertension
Analysis of Genes Related to Angiotensin II-Induced Arterial Injury Using a Time Series Microarray.
Hypertension
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension.
Hypertension
Selective effect of high arterial pressure in hypertension upon inhibition of cGMP versus cAMP mediated vascular relaxation.
Hypertension
Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes.
Hypertension
WNK1, a kinase mutated in inherited hypertension with hyperkalemia, localizes to diverse Cl- -transporting epithelia.
Hypertension
WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).
Hyperthyroidism
Cyclic AMP-dependent protein kinase activation in hearts from euthyroid and hyperthyroid rats.
Hyperthyroidism
Hyperthyroidism affects the activity of a cAMP-dependent protein kinase and protein phosphorylation in heart sarcolemma.
Hyperthyroidism
The effect of thyroxine on the calmodulin-dependent (Ca2+-Mg2+)ATPase activity and protein phosphorylation in rabbit fast skeletal muscle sarcolemma.
Hypertrophy, Left Ventricular
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.
Hypoglycemia
Acute Hypoglycemia in Healthy Humans Impairs Insulin-Stimulated Glucose Uptake and Glycogen Synthase in Skeletal Muscle: A Randomized Clinical Study.
Hypoglycemia
Constitutive Activation of AKT2 in Humans Leads to Hypoglycemia Without Fatty Liver or Metabolic Dyslipidemia.
Hypophosphatemia, Familial
Cyclic AMP-dependent protein phosphorylation in canine renal brush-border membrane vesicles is associated with decreased phosphate transport.
Ichthyosis
Trypanosoma brucei harbours a divergent XPB helicase paralogue that is specialized in nucleotide excision repair and conserved among kinetoplastid organisms.
Infections
A kinase able to phosphorylate exogenous protein synthesis initiation factor eIF-2 alpha is present in lysates of mengovirus-infected L cells.
Infections
A putative PKA phosphorylation site S227 in MoSom1 is essential for infection-related morphogenesis and pathogenicity in Magnaporthe oryzae.
Infections
An expanded subfamily of G-protein-coupled receptor genes in Fusarium graminearum required for wheat infection.
Infections
Complementation of the Magnaporthe grisea deltacpkA mutation by the Blumeria graminis PKA-c gene: functional genetic analysis of an obligate plant pathogen.
Infections
Coxiella burnetii Exploits Host cAMP-Dependent Protein Kinase Signaling to Promote Macrophage Survival.
Infections
Helicobacter pylori-induced modification of the histone H3 phosphorylation status in gastric epithelial cells reflects its impact on cell cycle regulation.
Infections
Hepatitis C Virus Infection Induces Hepatic Expression of NF-?B-Inducing Kinase and Lipogenesis by Downregulating miR-122.
Infections
Herpes simplex virus type 1 infection induces the stabilization of p53 in a USP7- and ATM-independent manner.
Infections
Host Kinase Activity is Required for Coxiella burnetii Parasitophorous Vacuole Formation.
Infections
Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library.
Infections
In vivo and in vitro phosphorylation of DNA-dependent RNA polymerase of Escherichia coli by bacteriophage-T7-induced protein kinase.
Infections
Increased mitogen-activated protein kinase activity and TNF-alpha production associated with Mycobacterium smegmatis- but not Mycobacterium avium-infected macrophages requires prolonged stimulation of the calmodulin/calmodulin kinase and cyclic AMP/protein kinase A pathways.
Infections
Indispensable functions of ABL and PDGF receptor kinases in epithelial adherence of attaching/effacing pathogens under physiological conditions.
Infections
Induction of a cytosolic pyruvate kinase 1 gene during the resistance response to Tobacco mosaic virus in Capsicum annuum.
Infections
Oxidant activated soluble adenylate cyclase of Leishmania donovani regulates the cAMP-PKA signaling axis for its intra-macrophage survival during infection.
Infections
Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus.
Infections
Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells.
Infections
Syk and JNK signaling pathways are involved in inflammasome activation in macrophages infected with Streptococcus pneumoniae.
Infections
The cAMP signaling pathway in Fusarium verticillioides is important for conidiation, plant infection, and stress responses but not fumonisin production.
Infections
The cAMP-PKA pathway regulates growth, sexual and asexual differentiation, and pathogenesis in Fusarium graminearum.
Infections
The cyclase-associated protein FgCap1 has both protein kinase A-dependent and -independent functions during deoxynivalenol production and plant infection in Fusarium graminearum.
Infections
The gene fpk1, encoding a cAMP-dependent protein kinase catalytic subunit homolog, is required for hyphal growth, spore germination, and plant infection in Fusarium verticillioides.
Infections
The two faces of Janus: virulence gene regulation by CovR/S in group A streptococci.
Infections
Two novel transcriptional regulators are essential for infection-related morphogenesis and pathogenicity of the rice blast fungus Magnaporthe oryzae.
Infections
Virus-induced atherosclerosis. Herpesvirus infection alters aortic cholesterol metabolism and accumulation.
Infertility
Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Infertility
Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men.
Insulin Resistance
Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD.
Insulin Resistance
Cilostazol ameliorates metabolic abnormalities with suppression of proinflammatory markers in a db/db mouse model of type 2 diabetes via activation of peroxisome proliferator-activated receptor gamma transcription.
Insulin Resistance
Discriminative insulin antagonism of stimulatory effects of various cAMP analogs on adipocyte lipolysis and hepatocyte glycogenolysis.
Insulin Resistance
Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity.
Insulin Resistance
Gingerenone A sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase.
Insulin Resistance
Palmitic acid but not palmitoleic acid induces insulin resistance in a human endothelial cell line by decreasing SERCA pump expression.
Insulin Resistance
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.
Insulin Resistance
Protein kinase C theta (PKCtheta)-dependent phosphorylation of PDK1 at Ser504 and Ser532 contributes to palmitate-induced insulin resistance.
Insulinoma
Identification of cAMP-Dependent Kinase as a Third in Vivo Ribosomal Protein S6 Kinase in Pancreatic beta-Cells.
Intellectual Disability
Aminoglycoside drugs induce efficient read-through of CDKL5 nonsense mutations, slightly restoring its kinase activity.
Intellectual Disability
Variants in PRKAR1B cause a neurodevelopmental disorder with autism spectrum disorder, apraxia, and insensitivity to pain.
Intestinal Volvulus
Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.
Intestinal Volvulus
Isolation and characterization of the regulatory subunit of cAMP-dependent protein kinase from the filarial parasite Onchocerca volvulus.
Irritable Bowel Syndrome
Aquaporins 1, 3 and 8 expression and cytokines in irritable bowel syndrome rats' colon via cAMP-PKA pathway.
Ischemic Attack, Transient
Changes of [3H]cyclic adenosine monophosphate binding in the gerbil brain following transient cerebral ischemia: an autoradiographic study and investigation of the effects of vinconate and pentobarbital.
Ischemic Attack, Transient
Sequential alterations of [3H]rolipram and [3H]cyclic adenosine monophosphate binding in the gerbil brain following transient cerebral ischemia.
Kidney Failure, Chronic
Diet-induced hyperhomocysteinemia impairs vasodilation in 5/6-nephrectomized rats.
Kidney Neoplasms
Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles.
Kidney Neoplasms
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.
Kidney Neoplasms
Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics.
Legionnaires' Disease
Spectinomycin kinase from Legionella pneumophila. Characterization of substrate specificity and identification of catalytically important residues.
Leiomyoma
Human uterine smooth muscle and leiomyoma cells differ in their rapid 17beta-estradiol signaling: implications for proliferation.
Lentigo
Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.
Leukemia
8-Cl-cAMP induces truncation and down-regulation of the RI alpha subunit and up-regulation of the RII beta subunit of cAMP-dependent protein kinase leading to type II holoenzyme-dependent growth inhibition and differentiation of HL-60 leukemia cells.
Leukemia
Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.
Leukemia
Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.
Leukemia
Cell signaling through the protein kinases cAMP-dependent protein kinase, protein kinase Cepsilon, and RAF-1 regulates amphotropic murine leukemia virus envelope protein-induced syncytium formation.
Leukemia
Circumvention of multidrug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87.
Leukemia
Cooperative interactions of protein kinase C and cAMP-dependent protein kinase systems in human promyelocytic leukemia HL60 cells.
Leukemia
Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
Leukemia
Ligand-induced phosphorylation of anaphylatoxin receptors C3aR and C5aR is mediated by "G protein-coupled receptor kinases.
Leukemia
Retroviral vector-mediated overexpression of the RII beta subunit of the cAMP-dependent protein kinase induces differentiation in human leukemia cells and reverts the transformed phenotype of mouse fibroblasts.
Leukemia
Reversal of resistance to adriamycin by 8-chloro-cyclic AMP in adriamycin-resistant HL-60 leukemia cells is associated with reduction of type I cyclic AMP-dependent protein kinase and cyclic AMP response element-binding protein DNA-binding activities.
Leukemia
Suppressive neutrophils require PIM1 for metabolic fitness and survival during chronic viral infection.
Leukemia
Targeting the kinase activity of the BCR-ABL fusion protein in patients with chronic myeloid leukemia.
Leukemia
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Leukemia
Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells.
Leukemia, Erythroblastic, Acute
cAMP-dependent protein kinase is necessary for increased NF-E2.DNA complex formation during erythroleukemia cell differentiation.
Leukemia, Erythroblastic, Acute
Chemically induced murine erythroleukemia cell differentiation is severely impaired when cAMP-dependent protein kinase activity is repressed by transfected genes.
Leukemia, Erythroblastic, Acute
Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation
Leukemia, Erythroblastic, Acute
Identification of a ras-related protein in murine erythroleukemia cells that is a cAMP-dependent protein kinase substrate and is phosphorylated during chemically induced differentiation.
Leukemia, Erythroblastic, Acute
Impaired erythroid-specific gene expression in cAMP-dependent protein kinase-deficient murine erythroleukemia cells.
Leukemia, Erythroblastic, Acute
NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival.
Leukemia, Erythroblastic, Acute
Protein kinase activity, growth and differentiation of murine erythroleukemia cells.
Leukemia, Lymphocytic, Chronic, B-Cell
p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation.
Leukemia, Lymphocytic, Chronic, B-Cell
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Aurora A Kinase Inhibitor AKI603 Induces Cellular Senescence in Chronic Myeloid Leukemia Cells Harboring T315I Mutation.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cancer drug resistance: the central role of the karyotype.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Cytomegalovirus-induced Hemorrhagic Colitis in a Patient with Chronic Myeloid Leukemia (Chronic Phase) on Dasatinib as an Upfront Therapy.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Determining the rise in BCR-ABL RNA that optimally predicts a kinase domain mutation in patients with chronic myeloid leukemia on imatinib.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
New assignments for multitasking signal transduction inhibitors.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukemia and significantly increases the efficacy of nilotinib.
Leukemia, Myeloid
Cyclic AMP-dependent protein kinase isoenzymes in human myeloid leukemia (HL60) and breast tumor (MCF-7) cells.
Leukemia, Myeloid
Microinjected catalytic subunit of cAMP-dependent protein kinase induces apoptosis in myeloid leukemia (IPC-81) cells.
Leukemia, Myeloid
Regulation of jun-B expression by a cyclic AMP (cAMP)-dependent mechanism in human myeloid cells.
Leukemia, Myeloid
Selective cleavage of 28S rRNA variable regions V3 and V13 in myeloid leukemia cell apoptosis.
Leukemia, Myeloid, Acute
A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia.
Leukemia, Myeloid, Acute
An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes.
Leukemia, Myeloid, Acute
Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes.
Leukemia, Myeloid, Acute
Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.
Leukemia, Myeloid, Acute
Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.
Leukemia, Myeloid, Acute
State of the art of the therapeutic perspective of Sorafenib against hematological malignancies.
Leukemia, Promyelocytic, Acute
Activation of Both Protein Kinase A (PKA) Type I and PKA Type II Isozymes Is Required for Retinoid-Induced Maturation of Acute Promyelocytic Leukemia Cells.
Leukemia, Promyelocytic, Acute
Two distinctly regulated events, priming and triggering, during retinoid-induced maturation and resistance of NB4 promyelocytic leukemia cell line.
Leukemia, Promyelocytic, Acute
Tyrosine kinases but not cAMP-dependent protein kinase mediate the induction of leukocyte alkaline phosphatase by granulocyte-colony-stimulating factor and retinoic acid in acute promyelocytic leukemia cells.
Leukemia, T-Cell
ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection.
Leukemia-Lymphoma, Adult T-Cell
Aurora A selective inhibitor MLN8237 suppresses the growth and survival of HTLV-1-infected T-cells in vitro.
Liver Cirrhosis
Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
Liver Diseases
Activation of cyclic adenosine monophosphate-dependent protein kinase a signaling prevents liver ischemia/reperfusion injury in mice.
Liver Neoplasms
A polymeric nanoparticle formulation of curcumin in combination with sorafenib synergistically inhibits tumor growth and metastasis in an orthotopic model of human hepatocellular carcinoma.
Liver Neoplasms
Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles.
Liver Neoplasms
c-Myc is a major determinant for antitumor activity of Aurora A kinase inhibitor MLN8237 in thyroid cancer.
Liver Neoplasms
Comprehensive analysis of The Cancer Genome Atlas reveals a unique gene and non-coding RNA signature of fibrolamellar carcinoma.
Liver Neoplasms
Human Serum Albumin Nanoparticles as a Carrier for On-Demand Sorafenib Delivery.
Liver Neoplasms
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
Lordosis
Differential effect of kinase A and C blockers on lordosis facilitation by progesterone and its metabolites in ovariectomized estrogen-primed rats.
Lordosis
In the ventral tegmental area, progestins' membrane-mediated actions for lordosis of hamsters and rats involve protein kinase A.
Lordosis
Membrane actions of progestins at dopamine type 1-like and GABAA receptors involve downstream signal transduction pathways.
Lung Neoplasms
Activation of Aurora A kinase increases YAP stability via blockage of autophagy.
Lung Neoplasms
Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies.
Lung Neoplasms
Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: Exposure-Response Analyses of Pivotal ALTA Study.
Lung Neoplasms
cAMP-dependent protein kinase is essential for hypoxia-mediated epithelial-mesenchymal transition, migration, and invasion in lung cancer cells.
Lung Neoplasms
Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation.
Lung Neoplasms
Clinical and molecular characteristics of Chinese non-small cell lung cancer patients with ERBB2 transmembrane domain mutations.
Lung Neoplasms
Deep and Prolonged Response to Aurora A Kinase Inhibitor and Subsequently to Nivolumab in MYCL1-Driven Small-Cell Lung Cancer: Case Report and Literature Review.
Lung Neoplasms
Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins.
Lung Neoplasms
Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer.
Lung Neoplasms
JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M.
Lung Neoplasms
Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines.
Lung Neoplasms
Molecular Modeling, Docking, Dynamics and simulation of Gefitinib and its derivatives with EGFR in Non-Small Cell Lung Cancer.
Lung Neoplasms
Selective activation of cyclic AMP dependent protein kinase by calcitonin in a calcitonin secreting lung cancer cell line.
Lung Neoplasms
Synthesis and preliminary PET imaging of (11)C and (18)F isotopologues of the ROS1/ALK inhibitor lorlatinib.
Lung Neoplasms
The Potent ALK Inhibitor Brigatinib (AP26113) Overcomes Mechanisms of Resistance to First- and Second-Generation ALK Inhibitors in Preclinical Models.
Lung Neoplasms
Transcriptional regulation of oncogenic protein kinase C? (PKC?) by STAT1 and Sp1 proteins.
Lung Neoplasms
[Experimental study of effects of nm23-H1 gene transfection on the change of PKA activity in human high-metastasis large cell lung cancer cell line L9981.]
Lung Neoplasms
[Medical treatment of small cell lung cancer: Can we leave the area of cisplatin-etoposide?]
Lung Neoplasms
[PRKAR1? expression in non-small cell lung cancer and ?its clinicopathologic significance].
Lung Neoplasms
[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]
Lupus Erythematosus, Systemic
Association of deficient type II protein kinase A activity with aberrant nuclear translocation of the RII beta subunit in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
Deficient type I protein kinase A isozyme activity in systemic lupus erythematosus T lymphocytes: II. Abnormal isozyme kinetics.
Lupus Erythematosus, Systemic
Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes.
Lupus Erythematosus, Systemic
High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.
Lupus Erythematosus, Systemic
mRNA mutations of type I protein kinase A regulatory subunit alpha in T lymphocytes of a subject with systemic lupus erythematosus.
Lupus Erythematosus, Systemic
Protein kinase A (PKA)--a potential target for therapeutic intervention of dysfunctional immune cells.
Lupus Erythematosus, Systemic
Protein kinase A RI beta subunit deficiency in lupus T lymphocytes: bypassing a block in RI beta translation reconstitutes protein kinase A activity and augments IL-2 production.
Lymphatic Metastasis
Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.
Lymphoma
A kinase-negative mutant of S49 mouse lymphoma cells is defective in posttranslational maturation of catalytic subunit of cyclic AMP-dependent protein kinase.
Lymphoma
A structural gene mutation affecting the regulatory subunit of cyclic AMP-dependent protein kinase in mouse lymphoma cells.
Lymphoma
Activation of cAMP-dependent protein kinase is required for heterologous desensitization of adenylyl cyclase in S49 wild-type lymphoma cells.
Lymphoma
Activation of type I cyclic AMP-dependent protein kinases with defective cyclic AMP-binding sites.
Lymphoma
Altered regulation of cyclic AMP-dependent protein kinase in a mouse lymphoma cell line.
Lymphoma
Analysis of the dominance of mutations in cAMP-binding sites of murine type I cAMP-dependent protein kinase in activation of kinase from heterozygous mutant lymphoma cells.
Lymphoma
Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.
Lymphoma
Brigatinib Dose Rationale in Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer: Exposure-Response Analyses of Pivotal ALTA Study.
Lymphoma
Cell-free heterologous desensitization of adenylyl cyclase in S49 lymphoma cell membranes mediated by cAMP-dependent protein kinase.
Lymphoma
Cutting Edge: ROR1/CD19 Receptor Complex Promotes Growth of Mantle Cell Lymphoma Cells Independently of the B Cell Receptor-BTK Signaling Pathway.
Lymphoma
Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in murine T-lymphoma cells.
Lymphoma
Cyclic AMP-resistant mutants of S49 mouse lymphoma cells hemizygous for expression of regulatory subunit of type I cyclic AMP-dependent protein kinase.
Lymphoma
Fine-structure mapping of charge-shift mutations in regulatory subunit of type I cyclic AMP-dependent protein kinase.
Lymphoma
Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells.
Lymphoma
HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism.
Lymphoma
Homology between regulatory subunits of type 1 cyclic AMP-dependent protein kinases from bovine and murine cells.
Lymphoma
Hotspots for spontaneous and mutagen-induced lesions in regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells.
Lymphoma
Inhibition of Aurora A Kinase in Combination with Chemotherapy Induces Synthetic Lethality and Overcomes Chemoresistance in Myc-Overexpressing Lymphoma.
Lymphoma
Interactions between cyclic AMP- and phorbol ester-dependent phosphorylation systems in S49 mouse lymphoma cells.
Lymphoma
Kinase-negative mutants of S49 mouse lymphoma cells carry a trans-dominant mutation affecting expression of cAMP-dependent protein kinase.
Lymphoma
Linked spontaneous CG----TA mutations at CpG sites in the gene for protein kinase regulatory subunit.
Lymphoma
Management of relapses after hematopoietic cell transplantation in T-cell non-Hodgkin lymphomas.
Lymphoma
Mutations causing charge alterations in regulatory subunits of the cAMP-dependent protein kinase of cultured S49 lymphoma cells.
Lymphoma
Mutations that alter the charge of type I regulatory subunit and modify activation properties of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells.
Lymphoma
Pathways for degradation of the catalytic subunit of cAMP-dependent protein kinase differ in wild-type and kinase-negative S49 mouse lymphoma cells.
Lymphoma
Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction.
Lymphoma
Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose.
Lymphoma
Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Lymphoma
Phase II Study of Alisertib, a Selective Aurora A Kinase Inhibitor, in Relapsed and Refractory Aggressive B- and T-Cell Non-Hodgkin Lymphomas.
Lymphoma
Phosphorylation of regulatory subunit of type I cyclic AMP-dependent protein kinase: biphasic effects of cyclic AMP in intact S49 mouse lymphoma cells.
Lymphoma
Revertants of a trans-dominant S49 mouse lymphoma mutant that affects expression of cAMP-dependent protein kinase.
Lymphoma
Second-site mutations in cyclic AMP-sensitive revertants of a Ka mutant of S49 mouse lymphoma cells reduce the affinity of regulatory subunit of cyclic AMP-dependent protein kinase for catalytic subunit.
Lymphoma
Sites of phosphorylation and mutation in regulatory subunit of cyclic AMP-dependent protein kinase from S49 mouse lymphoma cells: mapping to structural domains.
Lymphoma
Spectrum of spontaneous missense mutations causing cyclic AMP-resistance phenotypes in cultured S49 mouse lymphoma cells differs markedly from those of mutations induced by alkylating mutagens.
Lymphoma
Studies on the phosphorylation and synthesis of type I regulatory subunit of cyclic AMP-dependent protein kinase in intact S49 mouse lymphoma cells.
Lymphoma
Subunit interaction in cyclic AMP-dependent protein kinase of mutant lymphoma cells.
Lymphoma
Synthesis and preliminary PET imaging of (11)C and (18)F isotopologues of the ROS1/ALK inhibitor lorlatinib.
Lymphoma
The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.
Lymphoma
The S49 Kin- cell line transcribes and translates a functional mRNA coding for the catalytic subunit of cAMP-dependent protein kinase.
Lymphoma
Turnover of regulatory subunit of cyclic AMP-dependent protein kinase in S49 mouse lymphoma cells. Regulation by catalytic subunit and analogs of cyclic AMP.
Lymphoma, B-Cell
Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/vincristine in Relapsed/refractory Aggressive B-cell Lymphoma.
Lymphoma, B-Cell
Role of cyclin A and p27 in anti-IgM induced G1 growth arrest of murine B-cell lymphomas.
Lymphoma, Large B-Cell, Diffuse
Design, Synthesis, and Biological Evaluation of IRAK4-Targeting PROTACs.
Lymphoma, Mantle-Cell
Cutting Edge: ROR1/CD19 Receptor Complex Promotes Growth of Mantle Cell Lymphoma Cells Independently of the B Cell Receptor-BTK Signaling Pathway.
Lymphoma, Non-Hodgkin
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.
Lymphoma, Non-Hodgkin
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Lymphoma, Non-Hodgkin
Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/vincristine in Relapsed/refractory Aggressive B-cell Lymphoma.
Lymphoma, T-Cell
Aurora A Kinase Inhibition Selectively Synergizes with Histone Deacetylase Inhibitor through Cytokinesis Failure in T-cell Lymphoma.
Lymphoma, T-Cell
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).
Lymphoma, T-Cell, Peripheral
Randomized Phase III Study of Alisertib or Investigator's Choice (Selected Single Agent) in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma.
Lymphoproliferative Disorders
The role of aurora A and polo-like kinases in high-risk lymphomas.
Malaria
Expression and biochemical characterization of the Plasmodium falciparum protein kinase A catalytic subunit.
Malaria
The H89 cAMP-dependent protein kinase inhibitor blocks Plasmodium falciparum development in infected erythrocytes.
Malformations of Cortical Development, Group II
zyg-8, a gene required for spindle positioning in C. elegans, encodes a doublecortin-related kinase that promotes microtubule assembly.
Malnutrition
Activity of cAMP-dependent protein kinase is reduced in protein-energy malnourished rats.
Mastocytoma
Mammalian histidine decarboxylase: effect by protein kinase on mouse mastocytoma histidine decarboxylase.
Measles
Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy.
Medulloblastoma
A Sensitized RNA Interference Screen Identifies a Novel Role for the PI3K p110{gamma} Isoform in Medulloblastoma Cell Proliferation and Chemoresistance.
Melanoma
Activation of cAMP-dependent protein kinase is required for optimal alpha-melanocyte-stimulating hormone-induced pigmentation.
Melanoma
Activation of melanoma tyrosinase by a cyclic AMP-dependent protein kinase in a cell-free system.
Melanoma
ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment.
Melanoma
Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group.
Melanoma
Diethylstilbestrol enhances melanogenesis via cAMP-PKA-mediating up-regulation of tyrosinase and MITF in mouse B16 melanoma cells.
Melanoma
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Melanoma
Differential expression of cyclic AMP-dependent protein kinase isozymes in normal human melanocytes and malignant melanomas.
Melanoma
Differential expression of protein kinase C and cAMP-dependent protein kinase in normal human melanocytes and malignant melanomas.
Melanoma
Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway.
Melanoma
Effect of alpha tocopheryl succinate on cyclic AMP-dependent protein kinase activity in murine B-16 melanoma cells in culture.
Melanoma
Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics.
Melanoma
Evidence suggesting that a cyclic AMP-dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells.
Melanoma
Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells.
Melanoma
Human melanoma TrkC: its association with a purine-analog-sensitive kinase activity.
Melanoma
Human papillomavirus evaluation of vemurafenib induced skin epithelial tumors: a case series.
Melanoma
Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.
Melanoma
Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and phosphatidylinositol 3-kinase pathways.
Melanoma
PP6C Hotspot Mutations in Melanoma Display Sensitivity to Aurora Kinase Inhibition.
Melanoma
Reaccion acneiforme noduloquistica secundaria a vemurafenib con buena respuesta a isotretinoina oralSevere acneiform eruption associated with vemurafenib with response to isotretinoin.
Melanoma
Retinoic acid increases cyclic AMP-dependent protein kinase activity in murine melanoma cells.
Melanoma
Suppression of cyclic AMP-dependent protein kinase activity in murine melanoma cells by 12-0-tetradecanoylphorbol-13-acetate.
Melanoma, Experimental
Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia.
Melanoma, Experimental
Evidence suggesting that a cyclic AMP-dependent protein kinase is a positive regulator of proliferation in Cloudman S91 melanoma cells.
Melanoma, Experimental
Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.
Melanoma, Experimental
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.
Memory Disorders
Altered autophosphorylation of adenosine 3',5'-phosphate-dependent protein kinase in the dunce memory mutant of Drosophila melanogaster.
Meningitis
The cAMP/protein kinase A signaling pathway in pathogenic basidiomycete fungi: Connections with iron homeostasis.
Mesothelioma, Malignant
A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma.
Microcephaly
Cellular and clinical impact of haploinsufficiency for genes involved in ATR signaling.
Mucocutaneous Lymph Node Syndrome
PPP3CC feedback regulates IP3-Ca2+ pathway through preventing ITPKC degradation.
Multiple Myeloma
Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells.
Multiple Myeloma
Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
Multiple Myeloma
Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
Multiple Myeloma
Protein expression and purification of G-protein coupled receptor kinase 6 (GRK6), toward structure-based drug design and discovery for multiple myeloma.
Murine Acquired Immunodeficiency Syndrome
The RIAD peptidomimetic inhibits HIV-1 replication in humanized NSG mice.
Myasthenia Gravis
Gravin, an autoantigen recognized by serum from myasthenia gravis patients, is a kinase scaffold protein.
Mycoses
cAMP-pKA signaling regulates multiple steps of fungal infection cooperatively with Cmk1 MAP kinase in Colletotrichum lagenarium.
Myelodysplastic Syndromes
An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes.
Myeloproliferative Disorders
Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia.
Myeloproliferative Disorders
The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.
Myocardial Infarction
Cardiac cAMP-PKA Signaling Compartmentalization in Myocardial Infarction.
Myocardial Infarction
Cyclic AMP-dependent protein kinase and mechanical heart function in ventricular hypertrophy induced by pressure overload or secondary to myocardial infarction.
Myocardial Infarction
microRNA-208a in an early stage myocardial infarction rat model and the effect on cAMP-PKA signaling pathway.
Myocardial Infarction
RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction.
Myocardial Infarction
[cAMP-dependent phosphorylation of myocardial troponin in experimental myocardial infarction]
Myocardial Ischemia
Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4.
Myocardial Ischemia
Structural Basis for Phosphorylation and Lysine Acetylation Cross-talk in a Kinase Motif Associated with Myocardial Ischemia and Cardioprotection.
Myocarditis
The increase in viscosity and peroxidation of sarcoplasmic reticulum membrane lipids in isadrine myocarditis.
Myocarditis
[Effect of the catalytic subunit of cAMP-dependent protein kinase on the electrical activity of the rat heart in isadrine myocarditis]
Myotonic Dystrophy
Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases.
Myotonic Dystrophy
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
Myotonic Dystrophy
Unstable DNA may be responsible for the incomplete penetrance of the myotonic dystrophy phenotype.
Myxoma
Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.
Myxoma
Celecoxib treatment of fibrous dysplasia (FD) in a human FD cell line and FD-like lesions in mice with protein kinase A (PKA) defects.
Myxoma
Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.
Myxoma
Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma.
Neoplasm Metastasis
Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation.
Neoplasm Metastasis
DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
Neoplasm Metastasis
Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1.
Neoplasm Metastasis
Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
Neoplasm Metastasis
GPER-regulated lncRNA-Glu promotes glutamate secretion to enhance cellular invasion and metastasis in triple-negative breast cancer.
Neoplasm Metastasis
Neural cell adhesion molecule potentiates invasion and metastasis of melanoma cells through CAMP-dependent protein kinase and phosphatidylinositol 3-kinase pathways.
Neoplasm Metastasis
PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
Neoplasm Metastasis
Reciprocal activation within a kinase effector complex: A mechanism for the persistence of molecular memory.
Neoplasm Metastasis
RSK2 activity mediates glioblastoma invasiveness and is a potential target for new therapeutics.
Neoplasm Metastasis
Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.
Neoplasm Metastasis
SSeCKS/AKAP12 scaffolding functions suppress B16F10-induced peritoneal metastasis by attenuating CXCL9/10 secretion by resident fibroblasts.
Neoplasm Metastasis
Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells.
Neoplasm Metastasis
Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae.
Neoplasm Metastasis
Transcriptional regulation of oncogenic protein kinase C? (PKC?) by STAT1 and Sp1 proteins.
Neoplasm Metastasis
TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.
Neoplasm Metastasis
Treatment of distant metastases from follicular cell-derived thyroid cancer.
Neoplasm Metastasis
Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.
Neoplasm Metastasis
[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]
Neoplasm Metastasis
[Screening of a sub-clone of human breast cancer cells with high metastasis potential]
Neoplasms
"NEDD9 depletion destabilizes Aurora A kinase and heightens the efficacy of Aurora A inhibitors: implications for treatment of metastatic solid tumors."
Neoplasms
2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells.
Neoplasms
4EBP1/c-MYC/PUMA and NF?B/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.
Neoplasms
8-Chloro-cAMP inhibits transforming growth factor alpha transformation of mammary epithelial cells by restoration of the normal mRNA patterns for cAMP-dependent protein kinase regulatory subunit isoforms which show disruption upon transformation.
Neoplasms
8-Chloro-cyclic AMP inhibits autocrine and angiogenic growth factor production in human colorectal and breast cancer.
Neoplasms
A closer look at evolution: Variants (SNPs) of genes involved in skin pigmentation, including EXOC2, TYR, TYRP1, and DCT, are associated with 25(OH)D serum concentration.
Neoplasms
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
Neoplasms
A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer.
Neoplasms
A dominant interfering Bub1 mutant is insufficient to induce or alter thymic tumorigenesis in vivo, even in a sensitized genetic background.
Neoplasms
A first-in-human phase 1 and pharmacological study of TAS-119, a novel selective Aurora A kinase inhibitor in patients with advanced solid tumours.
Neoplasms
A high-throughput mechanofluidic screening platform for investigating tumor cell adhesion during metastasis.
Neoplasms
A kinase inhibition map approach for tumor sensitivity prediction and combination therapy design for targeted drugs.
Neoplasms
A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish.
Neoplasms
A phase I study of MK-5108, an oral aurora a kinase inhibitor, administered both as monotherapy and in combination with docetaxel, in patients with advanced or refractory solid tumors.
Neoplasms
A proteomics-based investigation on the anticancer activity of alisertib, an Aurora kinase A inhibitor, in hepatocellular carcinoma Hep3B cells.
Neoplasms
A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study.
Neoplasms
A safety and pharmacokinetic study of a mixed-backbone oligonucleotide (GEM231) targeting the type I protein kinase A by two-hour infusions in patients with refractory solid tumors.
Neoplasms
A single-injection protein kinase A-directed antisense treatment to inhibit tumour growth.
Neoplasms
A transgenic mouse bearing an antisense construct of regulatory subunit type 1A of protein kinase A develops endocrine and other tumours: comparison with Carney complex and other PRKAR1A induced lesions.
Neoplasms
Activation of cyclic AMP-dependent protein kinase activity during LPS stimulation of macrophage tumor cell line, J774.1.
Neoplasms
Adenosine 3',5'-monophosphate (cAMP)-dependent protein kinase activity in rodent pituitary tissue: possible role in cAMP-dependent hormone secretion.
Neoplasms
Adenosine 3'5'-cyclic monophosphate dependent protein kinase in human adrenocortical tumors.
Neoplasms
Adjacent sequence controls the response polarity of nitric oxide-sensitive Sp factor binding sites.
Neoplasms
Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression.
Neoplasms
Alisertib demonstrates significant antitumor activity in bevacizumab resistant, patient derived orthotopic models of glioblastoma.
Neoplasms
Alterations of protein kinase isozymes in transplantable human lung cancer with special reference to the phosphorylation of arylsulfatase B.
Neoplasms
Altered cellular ratio of type I and type II cyclic AMP-dependent protein kinase in human mammary tumors.
Neoplasms
Altered cyclic AMP-dependent protein kinase activity in a mutant adrenocortical tumor cell line.
Neoplasms
An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects.
Neoplasms
An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.
Neoplasms
AniScan Using Extracellular Cyclic AMP-Dependent Protein Kinase A as a Serum Biomarker Assay for the Diagnosis of Malignant Tumors in Dogs.
Neoplasms
Anti-Alzheimer's Disease Molecular Mechanism of Acori Tatarinowii Rhizoma Based on Network Pharmacology.
Neoplasms
Anti-chondroitin sulfate proteoglycan 4-specific antibodies modify the effects of vemurafenib on melanoma cells differentially in normoxia and hypoxia.
Neoplasms
Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F.
Neoplasms
Anticancer activity of the Aurora A kinase inhibitor MK-5108 in non-small-cell lung cancer (NSCLC) in vitro as monotherapy and in combination with chemotherapies.
Neoplasms
Anticarcinogenic effect of retinoids on 7,12-dimethylbenz(a)anthracene-induced mammary tumor induction, and its relationship to cyclic AMP-dependent protein kinase.
Neoplasms
Antisense depletion of RIalpha subunit of protein kinase A induces apoptosis and growth arrest in human breast cancer cells.
Neoplasms
Antisense DNA toward type I protein kinase A produces sustained inhibition of tumor growth.
Neoplasms
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment.
Neoplasms
Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.
Neoplasms
Antisense protein kinase A RIalpha acts synergistically with hydroxycamptothecin to inhibit growth and induce apoptosis in human cancer cells: molecular basis for combinatorial therapy.
Neoplasms
Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
Neoplasms
Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration.
Neoplasms
Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide.
Neoplasms
Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase.
Neoplasms
Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation.
Neoplasms
Appearance of 50,000- and 52,000-dalton cAMP receptor proteins in the nucleoli of regressing MCF-7 human breast cancer upon estrogen withdrawal.
Neoplasms
Arsenic exposure alters expression of cell cycle and lipid metabolism genes in the liver of adult zebrafish (Danio rerio).
Neoplasms
Ashwagandha derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity.
Neoplasms
Assessment of Aurora A kinase expression in breast cancer: a tool for early diagnosis?
Neoplasms
ATM and p53 combined analysis predicts survival in glioblastoma multiforme patients: A clinicopathologic study.
Neoplasms
ATM and P53 differentially regulate pancreatic beta cell survival in Ins1E cells.
Neoplasms
Aurora A Functional Single Nucleotide Polymorphism (SNP) Correlates With Clinical Outcome in Patients With Advanced Solid Tumors Treated With Alisertib, an Investigational Aurora A Kinase Inhibitor.
Neoplasms
Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes.
Neoplasms
Aurora A kinase expression is increased in leukemia stem cells, and a selective Aurora A kinase inhibitor enhances Ara-C-induced apoptosis in acute myeloid leukemia stem cells.
Neoplasms
Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
Neoplasms
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.
Neoplasms
Aurora A Kinase Is a Priority Pharmaceutical Target for the Treatment of Cancers.
Neoplasms
Aurora A overexpression and pVHL reduced expression are correlated with a bad kidney cancer prognosis.
Neoplasms
Aurora kinase A inhibitor, LY3295668 erbumine: a phase 1 monotherapy safety study in patients with locally advanced or metastatic solid tumors.
Neoplasms
Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha.
Neoplasms
BAP1 mutations define a homogeneous subgroup of hepatocellular carcinoma with fibrolamellar-like features and activated PKA.
Neoplasms
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors.
Neoplasms
Beta 2-adrenergic receptor regulation after transfection into a cell line deficient in the cAMP-dependent protein kinase.
Neoplasms
Bioactive compounds in plant materials for the prevention of diabetesand obesity.
Neoplasms
Biochemical characterization of extracellular cAMP-dependent protein kinase as a tumor marker.
Neoplasms
Biochemical parameters in the anterior pituitary during the course of tumorigenesis induced by diethylstilbestrol treatment.
Neoplasms
Biotransformation Pathways and Metabolite Profiles of Oral [14C]Alisertib (MLN8237), an Investigational Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
Neoplasms
CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene.
Neoplasms
cAMP-dependent protein kinase activation inhibits proliferation and enhances apoptotic effect of tumor necrosis factor-alpha in NCI-H295R adrenocortical cells.
Neoplasms
cAMP-dependent protein kinase II interactions with nuclei derived from rat mammary tumor.
Neoplasms
cAMP-independent protein kinase activity is correlated with growth of rat mammary tumors.
Neoplasms
cAMP-mediated modulation of signal transduction of epidermal growth factor (EGF) receptor systems in human epidermoid carcinoma A431 cells. Depression of EGF-dependent diacylglycerol production and EGF receptor phosphorylation.
Neoplasms
cAMP-PKA inhibition of SK3 channel reduced both Ca(2+) entry and cancer cell migration by regulation of SK3-Orai1 complex.
Neoplasms
Candidate tumor suppressor B-cell translocation gene 3 impedes neoplastic progression by suppression of AKT.
Neoplasms
Carney complex syndrome manifesting as cardioembolic stroke: a case report and review of the literature.
Neoplasms
Casein kinase 1?-dependent feedback loop controls autophagy in RAS-driven cancers.
Neoplasms
CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.
Neoplasms
Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery.
Neoplasms
Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint.
Neoplasms
Cellular localization and age-dependent changes in mRNA for cyclic adenosine 3',5'-monophosphate-dependent protein kinases in rat testis.
Neoplasms
Changes in cyclic adenosine monophosphate-responsive element binding proteins in rat hepatomas.
Neoplasms
Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.
Neoplasms
Characteristics of extracellular cyclic AMP-dependent protein kinase as a biomarker of cancer in dogs.
Neoplasms
Characterization of cell surface adenosine 3',5'-monophosphate-binding proteins in Y-1 mouse adrenal tumor cells.
Neoplasms
Characterization of protein tyrosine kinase activity in murine Leydig tumor cells.
Neoplasms
Characterization of surfaces presenting covalently immobilized oligopeptides using near-edge X-ray absorption fine structure spectroscopy.
Neoplasms
Characterization of the cyclic adenosine 3':5'-monophosphate effector system in hormone-dependent and hormone-independent rat mammary carcinomas.
Neoplasms
Characterization of the morphological, growth, and steroidogenic effect of TPA on mouse Y-1 adrenal cortical tumor cells in culture.
Neoplasms
Chemoprevention with Protein Kinase A RI{alpha} Antisense in DMBA-Mammary Carcinogenesis.
Neoplasms
Chromosome instability modulated by BMI1-AURKA signaling drives progression in head and neck cancer.
Neoplasms
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma.
Neoplasms
Clinical Benefit to an Aurora A Kinase Inhibitor in a Patient with Metastatic Integrase Interactor 1-Deficient Carcinoma.
Neoplasms
Clinical studies in patients with solid tumors using a second-generation antisense oligonucleotide (GEM 231) targeted against protein kinase A type I.
Neoplasms
Compensatory stabilization of RIIbeta protein, cell cycle deregulation, and growth arrest in colon and prostate carcinoma cells by antisense-directed down-regulation of protein kinase A RIalpha protein.
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Constitutive levels of cAMP-dependent protein kinase activity determine sensitivity of human multidrug-resistant leukaemic cell lines to growth inhibition and apoptosis by forskolin and tumour necrosis factor alpha.
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Constitutive regulation of mitochondrial morphology by Aurora A kinase depends on a predicted cryptic targeting sequence at the N-terminus.
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Cooperative antiproliferative effects of 8-chloro-cyclic AMP and 528 anti-epidermal growth factor receptor monoclonal antibody on human cancer cells.
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Cooperative inhibitory effect of novel mixed backbone oligonucleotide targeting protein kinase A in combination with docetaxel and anti-epidermal growth factor-receptor antibody on human breast cancer cell growth.
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Correlation of estrogen receptors and charge alterations of regulatory subunits of cAMP-dependent protein kinases in human mammary tumor cells.
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Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.
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Cortisol-secreting adrenocortical tumours in dogs and their relevance for human medicine.
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CpG immunomer DNA enhances antisense protein kinase A RIalpha inhibition of multidrug-resistant colon carcinoma growth in nude mice: molecular basis for combinatorial therapy.
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Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition.
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CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
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Cyclic adenosine 3':5-monophosphate receptor proteins in hormone-dependent and -independent rat mammary tumors.
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Cyclic AMP and tumor promoters cause differential induction of ornithine decarboxylase and accumulation of putrescine in Chinese hamster ovary cells deficient in cyclic AMP-dependent protein kinase.
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Cyclic AMP-dependent protein kinase catalytic subunit A (PRKACA): the expected, the unexpected, and what might be next.
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Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells.
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Cyclic AMP-dependent protein kinase type I and type II and cyclic AMP binding in human mammary tumors.
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Cyclic AMP-dependent protein kinase type I is involved in hypersensitivity of human breast cells to topoisomerase II inhibitors.
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Cyclic AMP-dependent protein kinase-mediated desensitisation of adrenal tumour cells.
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Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury.
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Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases.
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Cytotoxic activity of effector T cells against cholangiocarcinoma is enhanced by self-differentiated monocyte-derived dendritic cells.
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Cytotoxic and anticancer activities of isatin and its derivatives: a comprehensive review from 2000-2008.
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Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells.
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DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
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Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function.
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Decreased adenylyl cyclase and cAMP-dependent protein kinase activities inhibit the cytotoxic function of human natural killer cells.
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Decreased expression of the type I isozyme of cAMP-dependent protein kinase in tumor cell lines of lung epithelial origin.
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Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells.
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Design and Synthesis of 4-(Heterocyclic Substituted Amino)-1H-Pyrazole-3-Carboxamide Derivatives and Their Potent Activity against Acute Myeloid Leukemia (AML).
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Design, synthesis and bioevaluation of N-trisubstituted pyrimidine derivatives as potent aurora A kinase inhibitors.
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Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d]imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition.
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Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group.
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Dibutyryl cyclic AMP mimics ovariectomy: nuclear protein phosphorylation in mammary tumor regression.
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Differential effects of dibutyryl cyclic adenosine monophosphate and retinoic acid on the growth, differentiation, and cyclic adenosine monophosphate-binding protein of murine neuroblastoma cells.
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Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
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Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
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Differentiation of HL-60 leukemia by type I regulatory subunit antisense oligodeoxynucleotide of cAMP-dependent protein kinase.
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Disruption of protein kinase a regulation causes immortalization and dysregulation of D-type cyclins.
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Dissecting the 17?-estradiol pathways necessary for neuroglobin anti-apoptotic activity in breast cancer.
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Dissecting the circuitry of protein kinase A and cAMP signaling in cancer genesis: antisense, microarray, gene overexpression, and transcription factor decoy.
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DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.
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Double adrenocortical adenomas harboring independent KCNJ5 and PRKACA somatic mutations.
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Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors.
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Down-regulation of the cyclin A promoter by transforming growth factor-beta1 is associated with a reduction in phosphorylated activating transcription factor-1 and cyclic AMP-responsive element-binding protein.
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Down-regulation of tumor suppressor a kinase anchor protein 12 in human hepatocarcinogenesis by epigenetic mechanisms.
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Drug insight: Small-molecule inhibitors of protein kinases in the treatment of thyroid cancer.
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Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.
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Dysregulating IRES-Dependent Translation Contributes to Overexpression of Oncogenic Aurora A Kinase.
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EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase.
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Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies.
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Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas.
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Effect of Food on the Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237) in Patients with Advanced Solid Tumors.
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Effect of protein kinase inhibitors on activity of mammalian small heat-shock protein (HSP25) kinase.
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Effect of the protein kinase inhibitors, 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine H-7 and N-(2-[methylamino]ethyl)-5-isoquinoline-sulfonamide H-8 on Lewis lung carcinoma tumor progression.
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Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin.
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Effects of gastrin on tumor growth and cyclic nucleotide metabolism in xenotransplantable human gastric and colonic carcinomas in nude mice.
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Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignancies.
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Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.
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Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation.
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Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer.
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Expression of selected Aurora A kinase substrates in solely estrogen-induced ectopic uterine stem cell tumors in the Syrian hamster kidney.
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Extracellular activity of cyclic AMP-dependent protein kinase as a biomarker for human cancer detection: distribution characteristics in a normal population and cancer patients.
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Fbxo3-Dependent Fbxl2 Ubiquitination Mediates Neuropathic Allodynia through the TRAF2/TNIK/GluR1 Cascade.
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Functional Link between DNA Damage Responses and Transcriptional Regulation by ATM in Response to a Histone Deacetylase Inhibitor TSA.
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Ganoderma atrum polysaccharide evokes antitumor activity via cAMP-PKA mediated apoptotic pathway and down-regulation of Ca(2+)/PKC signal pathway.
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Genetic evidence that a phorbol ester tumor promoter stimulates ornithine decarboxylase activity by a pathway that is independent of cyclic AMP-dependent protein kinases in CHO cells.
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Genetic Landscape of Sporadic Unilateral Adrenocortical Adenomas Without PRKACA p.Leu206Arg Mutation.
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Genomic and sequence variants of protein kinase A regulatory subunit type 1? (PRKAR1B) in patients with adrenocortical disease and Cushing syndrome.
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Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells.
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Global population pharmacokinetics of the investigational Aurora A kinase inhibitor alisertib in cancer patients: Rationale for lower dosage in Asia.
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Globular adiponectin decreases leptin-induced tumor necrosis factor-alpha expression by murine macrophages: Involvement of cAMP-PKA and MAPK pathways.
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Glycogen synthase kinase-3 beta inhibitors as novel cancer treatments and modulators of antitumor immune responses.
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Gravin gene expression in acute leukaemias: clinical importance and review of the literature.
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Growth arrest and induction of apoptosis in breast cancer cells by antisense depletion of protein kinase A-RI alpha subunit: p53-independent mechanism of action.
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Haploinsufficiency for either one of the type-II regulatory subunits of protein kinase A improves the bone phenotype of Prkar1a+/- mice.
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Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
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High-throughput RNAi screening identifies a role for TNK1 in growth and survival of pancreatic cancer cells.
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Histopathological and genetic characterization of aldosterone-producing adenomas with concurrent subclinical cortisol hypersecretion: a case series.
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How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?
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Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-?B/AMP-activated kinase/myosin light chain kinase pathway.
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Hypermethylation of the AKAP12 promoter is a biomarker of Barrett's-associated esophageal neoplastic progression.
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Hypoxia induces a phase transition within a kinase signaling network in cancer cells.
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Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma.
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Identification of a multi-cancer gene expression biomarker for cancer clinical outcomes using a network-based algorithm.
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Identification of the ?-catenin/JNK/prothymosin-alpha axis as a novel target of sorafenib in hepatocellular carcinoma cells.
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Identification of the A kinase anchor protein 12 (AKAP12) gene as a candidate tumor suppressor of hepatocellular carcinoma.
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IKKbeta mediates cell shape-induced aromatase expression and estrogen biosynthesis in adipose stromal cells.
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Immunohistological studies on neoplasms of female and male Onchocerca volvulus: filarial origin and absence of Wolbachia from tumor cells.
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In Vivo FRET Imaging of Tumor Endothelial Cells Highlights a Role of Low PKA Activity in Vascular Hyperpermeability.
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Inactivation of the Carney complex gene 1 (protein kinase A regulatory subunit 1A) inhibits SMAD3 expression and TGF beta-stimulated apoptosis in adrenocortical cells.
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Increase of cyclic AMP-dependent protein kinase type II as an early event in hormone-dependent mammary tumor regression.
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Increased expression of the RIalpha subunit of the cAMP-dependent protein kinase A is associated with advanced stage ovarian cancer.
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Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells.
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Inhibition of growth and modulation of gene expression in human lung carcinoma in athymic mice by site-selective 8-Cl-cyclic adenosine monophosphate.
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Inhibition of intracellular cAMP-dependent protein kinase using mutant genes of the regulatory type I subunit.
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Inhibition of motile and invasive properties of ovarian cancer cells by ASODN against Rho-associated protein kinase.
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Inhibition of the self-renewal capacity of blast progenitors from acute myeloblastic leukemia patients by site-selective 8-chloroadenosine 3',5'-cyclic monophosphate.
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Instability of expanded simple tandem repeats is induced in cell culture by a variety of agents: N-Nitroso-N-ethylurea, benzo(a)pyrene, etoposide and okadaic acid.
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Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids.
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Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.
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Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples.
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Interactions between the epidermal growth factor receptor and type I protein kinase A: biological significance and therapeutic implications.
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Intratumoral administration of an adenovirus expressing a kinase dead form of ErbB-2 inhibits tumor growth.
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Investigational Aurora A kinase inhibitor alisertib (MLN8237) as an enteric-coated tablet formulation in non-hematologic malignancies: Phase 1 dose-escalation study.
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Involvement of IGF-I signaling pathway in the regulation of steroidogenesis in mouse Leydig cells treated with fenvalerate.
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JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells.
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Kaposi's Sarcoma Herpesvirus Upregulates Aurora A Expression to Promote p53 Phosphorylation and Ubiquitylation.
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Kinome sequencing reveals RET G691S polymorphism in human neuroendocrine lung cancer cell lines.
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Lack of modulation of MDR1 gene expression by dominant inhibition of cAMP-dependent protein kinase in doxorubicin-resistant MCF-7 breast cancer cells.
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Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
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LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.
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Localization of human TACC3 to mitotic spindles is mediated by phosphorylation on Ser558 by Aurora A: a novel pharmacodynamic method for measuring Aurora A activity.
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Loss of lymphocyte cyclic AMP dependent protein kinase activity in malignant melanoma.
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Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1? dependent upregulation of MYO3A gene in breast cancer cells.
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Mass balance, routes of excretion, and pharmacokinetics of investigational oral [14C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors.
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Mastl overexpression is associated with epithelial to mesenchymal transition and predicts a poor clinical outcome in gastric cancer.
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Mechanism of cancer cell death induced by depletion of an essential replication regulator.
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Melanocytic Myxoid Spindle Cell Tumor With ALK Rearrangement (MMySTAR): Report of 4 Cases of a Nevus Variant With Potential Diagnostic Challenge.
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Membranal tyrosine protein kinase activity (but not cAMP-dependent protein kinase activity) is associated with growth of rat mammary tumors.
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Metallothionein-1 as a biomarker of altered redox metabolism in hepatocellular carcinoma cells exposed to sorafenib.
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Mitochondrial A-kinase anchoring protein 121 binds type II protein kinase A and enhances steroidogenic acute regulatory protein-mediated steroidogenesis in MA-10 mouse leydig tumor cells.
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Mitogenic effects of cytokines on smooth muscle are critically dependent on protein kinase A and are unmasked by steroids and cyclooxygenase inhibitors.
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Mitotic Failures in Cancer: Aurora B Kinase and its Potential Role in the Development of Aneuploidy.
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Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3.
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MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo.
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Molecular Genetic and Genomic Alterations in Cushing's Syndrome and Primary Aldosteronism.
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Molecular mechanisms of corticotropin-releasing factor stimulation of calcium mobilization and adrenocorticotropin release from anterior pituitary tumor cells.
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Monitoring phosphoproteomic response to targeted kinase inhibitors using reverse-phase protein microarrays.
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mTOR pathway is activated by PKA in adrenocortical cells and participates in vivo to apoptosis resistance in primary pigmented nodular adrenocortical disease (PPNAD).
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Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision.
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Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles.
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Multiplexed tyrosine kinase activity detection in cancer cells using a hydrogel immobilized substrate.
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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
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Natural product-derived antitumor compound phenethyl isothiocyanate inhibits mTORC1 activity via TSC2.
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Neuroendocrine cancer. An activating hotspot mutation in PRKACA provides clues for adrenal Cushing syndrome therapeutics.
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New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
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New type of interaction between the SARAH domain of the tumour suppressor RASSF1A and its mitotic kinase Aurora A.
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Nuclear protein kinase substrates in AtT-20 cells: translocation of a 14 kDa phosphoprotein.
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Omega-3 and omega-6 fatty acids and PGE2 stimulate the growth of normal but not tumor mouse mammary epithelial cells: evidence for alterations in the signaling pathways in tumor cells.
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Open-label, multicenter, phase 1 study of alisertib (MLN8237), an aurora A kinase inhibitor, with docetaxel in patients with solid tumors.
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Pancreatic cancer-initiating cell exosome message transfer into noncancer-initiating cells: the importance of CD44v6 in reprogramming.
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Partial purification and characterization of the defective cyclic adenosine 3':5'-monophosphate binding protein kinase from adrenocortical carcinoma.
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Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
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Pentoxifylline and other protein kinase C inhibitors down-regulate HIV-LTR NF-kappa B induced gene expression.
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Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction.
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Phase 1 study of MLN8054, a selective inhibitor of Aurora A kinase in patients with advanced solid tumors.
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Phase 1 study of the investigational Aurora A kinase inhibitor alisertib (MLN8237) in East Asian cancer patients: pharmacokinetics and recommended phase 2 dose.
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Phase I assessment of new mechanism-based pharmacodynamic biomarkers for MLN8054, a small-molecule inhibitor of Aurora A kinase.
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Phase I Pharmacokinetic/Pharmacodynamic Study of MLN8237, an Investigational, Oral, Selective Aurora A Kinase Inhibitor, in Patients with Advanced Solid Tumors.
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Phase I Study of Aurora A Kinase Inhibitor Alisertib (MLN8237) in Combination With Selective VEGFR Inhibitor Pazopanib for Therapy of Advanced Solid Tumors.
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Phase I Study of Aurora A Kinase Inhibitor MLN8237 in Advanced Solid Tumors: Safety, Pharmacokinetics, Pharmacodynamics, and Bioavailability of Two Oral Formulations.
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Phase I study of MLN8237-investigational Aurora A kinase inhibitor-in relapsed/refractory multiple myeloma, Non-Hodgkin lymphoma and chronic lymphocytic leukemia.
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Phase I study of the aurora A kinase inhibitor alisertib with induction chemotherapy in patients with acute myeloid leukemia.
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Phase I study of the selective Aurora A kinase inhibitor MLN8054 in patients with advanced solid tumors: safety, pharmacokinetics, and pharmacodynamics.
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Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
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Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.
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Phosphorylation of human lysosomal arylsulfatase B by cAMP-dependent protein kinase. Different sites of phosphorylation between normal and cancer tissues.
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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.
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Phosphorylation of three proteins in the plasma membrane of Y-1 adrenal cells by a membrane-bound adenosine 3',5'-monophosphate-dependent protein kinase.
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PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
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Population Pharmacokinetic Analysis of Pexidartinib in Healthy Subjects and Patients With Tenosynovial Giant Cell Tumor or Other Solid Tumors.
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Potentiation of the anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the kinase inhibitor Staurosporine or its clinically relevant analogue UCN-01.
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Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors.
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Preclinical Drug Metabolism and Pharmacokinetics, and Prediction of Human Pharmacokinetics and Efficacious Dose of the Investigational Aurora A Kinase Inhibitor Alisertib (MLN8237).
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PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.
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PRKACA mutations in cortisol-producing adenomas and adrenal hyperplasia - a single-center study of 60 cases.
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Prkar1a haploinsufficiency ameliorates the growth hormone excess phenotype in Aip-deficient mice.
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Properties of p19, a novel cAMP-dependent protein kinase substrate protein purified from bovine brain.
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Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling.
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Prostaglandin E2-stimulated prostanoid EP4 receptors induce prolonged de novo prostaglandin E2 synthesis through biphasic phosphorylation of extracellular signal-regulated kinases mediated by activation of protein kinase A in HCA-7 human colon cancer cells.
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Protein Kinase A Catalytic Subunit Is a Molecular Switch that Promotes the Pro-tumoral Function of Macrophages.
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Protein kinase A effects of an expressed PRKAR1A mutation associated with aggressive tumors.
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Protein kinase A regulates caspase-1 via Ets-1 in bone stromal cell-derived lesions: a link between cyclic AMP and pro-inflammatory pathways in osteoblast progenitors.
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Protein kinase A-directed antisense restrains cancer growth: sequence-specific inhibition of gene expression.
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Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway.
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Protein Kinase D2 Modulates Cell Cycle By Stabilizing Aurora A Kinase at Centrosomes.
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Protein kinases A and C positively regulate G protein-dependent activation of phosphatidylinositol-specific phospholipase C by tumor necrosis factor-alpha in MC3T3-E1 osteoblasts.
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Protein phosphorylation in normal and neoplastic development. Cyclic AMP-dependent protein kinase activity in urethane-induced pulmonary tumours.
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Protein phosphorylation of human lysosomal arylsulfatase B from normal and cancer tissues.
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Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytes.
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PTEN Overexpression Cooperates With Lithium to Reduce the Malignancy and to Increase Cell Death by Apoptosis via PI3K/Akt Suppression in Colorectal Cancer Cells.
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Pyrido[2,3-d]pyrimidines: discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
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RAF dimers control vascular permeability and cytoskeletal rearrangements at endothelial cell-cell junctions.
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Rapid determination of AKAP12 promoter methylation levels in peripheral blood using methylation-sensitive high resolution melting (MS-HRM) analysis: application in colorectal cancer.
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Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
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Reaccion acneiforme noduloquistica secundaria a vemurafenib con buena respuesta a isotretinoina oralSevere acneiform eruption associated with vemurafenib with response to isotretinoin.
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Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways.
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Recovery of hormonal regulation in protein kinase defective adrenal cells through DNA-mediated gene transfer.
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Recovery of responsiveness to ACTH and cAMP in a protein kinase-defective adrenal cell mutant following transfection with a protein kinase gene.
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Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.
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Reduced gonadotropin responses in a novel clonal strain of Leydig tumor cells established by transfection of MA-10 cells with a mutant gene of the type I regulatory subunit of the cAMP-dependent protein kinase.
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Regression of hormone-dependent mammary tumors in Sprague-Dawley rats as a result of tamoxifen or pharmacologic doses of 17 beta-estradiol: cyclic adenosine 3',5'-monophosphate-mediated events.
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Regulation of ornithine decarboxylase activity by corticotropin in adrenocortical tumor cell clones: roles of cyclic AMP and cyclic AMP-dependent protein kinase.
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Regulatory subunit type I-alpha of protein kinase A (PRKAR1A): a tumor-suppressor gene for sporadic thyroid cancer.
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Relative bioavailability of a prototype oral solution of the Aurora A kinase inhibitor alisertib (MLN8237) in patients with advanced solid tumors.
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Release of lipoprotein lipase from Ehrlich ascites tumor produced by an association with a rapid increase in cyclic AMP content.
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Resistance to taxanes is induced by c-erbB-2 overexpression in human MCF-10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A.
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Retinal inhibits TPA activated, calcium-dependent, phospholipid-dependent protein kinase ("C" kinase).
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Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo.
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Reverse relationship between malignancy and cyclic AMP-dependent protein kinase activity in Yoshida rat ascites hepatomas.
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RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
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Rolipram, salbutamol and prostaglandin E2 suppress TNFalpha release from human monocytes by activating Type II cAMP-dependent protein kinase.
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Scientific Rationale Supporting the Clinical Development Strategy for the Investigational Aurora A Kinase Inhibitor Alisertib in Cancer.
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Search for Potent and Selective Aurora A Inhibitors Based on General Ser/Thr Kinase Pharmacophore Model.
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Serum and Glucocorticoid Inducible Kinase 1-Sensitive Survival, Proliferation and Migration of Rhabdomyosarcoma Cells.
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Sixteen-kinase gene expression identifies luminal breast cancers with poor prognosis.
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SMAD4 suppresses AURKA-induced metastatic phenotypes via degradation of AURKA in a TGF?-independent manner.
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Somatic mutations of the catalytic subunit of cyclic AMP-dependent protein kinase (PRKACA) gene in Japanese patients with several adrenal adenomas secreting cortisol [Rapid Communication].
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Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.
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Structure-based drug design: Synthesis and biological evaluation of quinazolin-4-amine derivatives as selective Aurora A kinase inhibitors.
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Suppression of multiple processes relevant to cancer progression by benzyl isothiocyanate may result from the inhibition of Aurora A kinase activity.
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Synergistic inhibition of growth of breast and colon human cancer cell lines by site-selective cyclic AMP analogues.
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Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells.
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Targeting NRAS(Q61K) mutant delays tumor growth and angiogenesis in non-small cell lung cancer.
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Targeting the interaction of Aurora kinases and SIRT1 mediated by Wnt signaling pathway in colorectal cancer: A critical review.
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TBK1 Activation by VHL Loss in Renal Cell Carcinoma: A Novel HIF-Independent Vulnerability.
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The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.
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The causal relationship between mutations in cAMP-dependent protein kinase and the loss of adrenocorticotropin-regulated adrenocortical functions.
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The cellular mechanisms of corticotropin-releasing hormone (CRH)-stimulated steroidogenesis in mouse Leydig cells are similar to those for LH.
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The differential regulation of steroidogenic acute regulatory protein-mediated steroidogenesis by type I and type II PKA in MA-10 cells.
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The in vitro effects of glycyrrhizin and the derivatives of glycyrrhetinic acid on the activity of cAMP-dependent protein kinase and phosphorylation of cellular polypeptide by the kinase from Ehrlich ascites tumor cells.
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The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.
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The landscape of fusion transcripts in spitzoid melanoma and biologically indeterminate spitzoid tumors by RNA sequencing.
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The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression.
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The regulatory subunit of cAMP-dependent protein kinase as a target for chemotherapy of cancer and other cellular dysfunctional-related diseases.
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The relationship of the cyclic nucleotide system to inhibition of hepatic drug metabolism in Walker 256 carcinoma-bearing rats.
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The roles of cAMP and cAMP-dependent protein kinase in forskolin's actions on Y1 adrenocortical tumor cells.
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The roles of cAMP and cAMP-dependent protein kinase in the expression of cholesterol side chain cleavage and steroid 11 beta-hydroxylase genes in mouse adrenocortical tumor cells.
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The roles of cAMP and cAMP-dependent protein kinase in the regulation of adrenocortical functions: analysis using DNA-mediated gene transfer.
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The tumor suppressor LATS2 reduces v-Src-induced membrane blebs in a kinase activity-independent manner.
Neoplasms
Traf2- and Nck-interacting kinase (TNIK) is involved in the anti-cancer mechanism of dovitinib in human multiple myeloma IM-9 cells.
Neoplasms
Transcriptional regulation of oncogenic protein kinase C? (PKC?) by STAT1 and Sp1 proteins.
Neoplasms
TRAP1 controls cell migration of cancer cells in metabolic stress conditions: Correlations with AKT/p70S6K pathways.
Neoplasms
TRAP1 downregulation in human ovarian cancer enhances invasion and epithelial-mesenchymal transition.
Neoplasms
Tumor phosphatidylinositol 3-kinase signaling in therapy resistance and metastatic dissemination of rectal cancer: Opportunities for signaling-adapted therapies.
Neoplasms
Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance.
Neoplasms
Type I and II cyclic adenosine 3':5'-monophosphate-dependent protein kinase in human gastric mucosa and carcinomas.
Neoplasms
Ultrastructural localization of cyclic adenosine 3',5'-monophosphate-dependent protein kinase after adrenocorticotropin stimulation in adrenal cortical tumor cells.
Neoplasms
Unexpected role for the human Cx37 C1019T polymorphism in tumour cell proliferation.
Neoplasms
Upregulation of a kinase interacting protein 1 in tongue squamous cell carcinoma correlates with lymph node metastasis and poor overall survival.
Neoplasms
Utilization of Liquid Chromatography Mass Spectrometry Analyses to Identify LKB1-APC Interaction in Modulating Wnt/?-Catenin Pathway of Lung Cancer Cells.
Neoplasms
Villous adenoma depletion syndrome. Evidence for a cyclic nucleotide-mediated diarrhea.
Neoplasms
Wee1 kinase inhibitor AZD1775 potentiates CD8+?T cell-dependent antitumour activity via dendritic cell activation following a single high dose of irradiation.
Neoplasms
XMD8-92 inhibits pancreatic tumor xenograft growth via a DCLK1-dependent mechanism.
Neoplasms
[Activation of protein kinase C and cAMP-dependent protein kinase in hormone-dependent mammary gland tumors during stimulation of their growth with progesterone and estrone]
Neoplasms
[Change in the protein kinase activity of glandular stomach mucosa in rats during malignant transformation]
Neoplasms
[Discovery of a new gene frequently inactivated in human cancers: protein p16, a cell cycle regulator]
Neoplasms
[Level of cyclic AMP-dependent protein kinase isozyme in normal liver and hepatoma tissue and the effect of sodium selenite]
Neoplasms
[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer.]
Neoplasms
[Screening of a sub-clone of human breast cancer cells with high metastasis potential]
Neoplasms
[The effect of estradiol on the activity of cAMP-dependent protein kinase in cells of estradiol-dependent tumors of the rat mammary gland. The role of a thermally stable protein inhibitor of cAMP-dependent protein kinase]
Neoplasms
[The inhibiting effect of 8-Cl-adenosine-3',5'-cyclophosphate on the growth of melanoma B-16 in mice]
Neuralgia
cAMP and cGMP contribute to sensory neuron hyperexcitability and hyperalgesia in rats with dorsal root ganglia compression.
Neuralgia
cAMP-PKA signaling is involved in regulation of spinal HCN channels function in diabetic neuropathic pain.
Neuralgia
Diminished inflammation and nociceptive pain with preservation of neuropathic pain in mice with a targeted mutation of the type I regulatory subunit of cAMP-dependent protein kinase.
Neuralgia
Inhibition of Adenylyl Cyclase in the Spinal Cord Alleviates Painful Diabetic Neuropathy in Zucker Diabetic Fatty Rats.
Neuroblastoma
Activation of cyclic AMP-dependent protein kinase and stimulation of protein phosphorylation in response to adenosine in C-1300 murine neuroblastoma.
Neuroblastoma
Aurora A is a negative prognostic factor and a new therapeutic target in human neuroblastoma.
Neuroblastoma
Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
Neuroblastoma
Characterization of a minimal promoter element required for transcription of the mouse type II beta regulatory subunit (RII beta) of cAMP-dependent protein kinase.
Neuroblastoma
Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.
Neuroblastoma
GD2 ganglioside-binding antibody 14G2a and specific aurora A kinase inhibitor MK-5108 induce autophagy in IMR-32 neuroblastoma cells.
Neuroblastoma
Identification of functional cAMP-dependent protein kinase in a 'neurite minus' mouse neuroblastoma cell line.
Neuroblastoma
Induction of the regulatory subunit of type I adenosine cyclic 3':5'-monophosphate-dependent protein kinase in differentiated N-18 mouse neuroblastoma cells.
Neuroblastoma
Inhibition of the NF-kappaB pathway enhances TRAIL-mediated apoptosis in neuroblastoma cells.
Neuroblastoma
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.
Neuroblastoma
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Neuroblastoma
Morphine inhibits cyclic AMP-dependent protein kinase and ornithine decarboxylase activities in neuroblastoma X glioma hybrid cells.
Neuroblastoma
Opposing influences of protein kinase activities on neurite outgrowth in human neuroblastoma cells: initiation by kinase A and restriction by kinase C.
Neuroblastoma
Orphanin FQ/nociceptin and mu-opioid receptor mRNA levels in human SH-SY5Y neuroblastoma cells: effects of activating the cAMP-PKA signal transduction pathway.
Neuroblastoma
Participation of type II protein kinase A in the retinoic acid-induced growth inhibition of SH-SY5Y human neuroblastoma cells.
Neuroblastoma
Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial.
Neuroblastoma
Phosphorylation of endogenous proteins by adenosine 3':5'-monophosphate-dependent protein kinase in mouse neuroblastoma cells.
Neuroblastoma
Regulation of relaxin 3 gene expression via cAMP-PKA in a neuroblastoma cell line.
Neuroblastoma
Targeting GD2 ganglioside and aurora A kinase as a dual strategy leading to cell death in cultures of human neuroblastoma cells.
Neuroblastoma
The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene.
Neuroblastoma
The interrelationship between selective tau phosphorylation and microtubule association.
Neuroblastoma
The synergy of BET inhibitors with aurora A kinase inhibitors in MYCN-amplified neuroblastoma is heightened with functional TP53.
Neuroblastoma
Type II protein kinase A up-regulation is sufficient to induce growth inhibition in SK-N-SH human neuroblastoma cells.
Neurodegenerative Diseases
Association study of the GSK-3B gene with tardive dyskinesia in European Caucasians.
Neurodegenerative Diseases
ATM-Dependent Phosphorylation of MEF2D Promotes Neuronal Survival after DNA Damage.
Neurodegenerative Diseases
Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
Neurofibromatoses
Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase.
Neurofibromatosis 1
Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase.
Neurofibrosarcoma
Aurora A kinase inhibition enhances oncolytic herpes virotherapy through cytotoxic synergy and innate cellular immune modulation.
Neuroinflammatory Diseases
Antioxidant, Anti-inflammatory and Neuroprotective Profiles of Novel 1,4-Dihydropyridine Derivatives for the Treatment of Alzheimer's Disease.
Nevus
Melanocytic Myxoid Spindle Cell Tumor With ALK Rearrangement (MMySTAR): Report of 4 Cases of a Nevus Variant With Potential Diagnostic Challenge.
Non-alcoholic Fatty Liver Disease
Antioxidative effects of Alisma orientale extract in palmitate-induced cellular injury.
non-specific serine/threonine protein kinase deficiency
High prevalence of T cell type I protein kinase A deficiency in systemic lupus erythematosus.
Obesity
Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism.
Obesity
Obesity does not lead to imbalance between myocardial phospholamban phosphorylation and dephosphorylation.
Obesity
Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.
Oligodendroglioma
An aberrant autocrine activation of the platelet-derived growth factor alpha-receptor in follicular and papillary thyroid carcinoma cell lines.
Osteochondrodysplasias
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Osteopetrosis
Accumulation of p100, a Precursor of NF-?B2, Enhances Osteoblastic Differentiation in Vitro and Bone Formation in Vivo in aly/aly Mice.
Osteopetrosis
Evidence that the kinase-truncated c-Src regulates NF-?B signaling by targeting NEMO.
Osteoporosis
Angiotensin II/Angiotensin II Receptor Blockade Affects Osteoporosis via the AT1/AT2-Mediated cAMP-Dependent PKA Pathway.
Osteosarcoma
A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells.
Osteosarcoma
Activation of adenosine 3',5'-monophosphate-dependent protein kinase in normal and malignant bone cells by parathyroid hormone, prostaglandin E2, and prostacyclin.
Osteosarcoma
Activity ratio measurements reflect intracellular activation of adenosine 3',5'-monophosphate-dependent protein kinase in osteoblasts.
Osteosarcoma
Glucocorticoid and 1,25-dihydroxyvitamin D modulate the degree of adenosine 3',5'-monophosphate-dependent protein kinase isoenzyme I and II activation by parathyroid hormone in rat osteosarcoma cells.
Osteosarcoma
Glucocorticoid treatment facilitates cyclic adenosine 3',5'-monophosphate-dependent protein kinase response in parathyroid hormone-responsive osteogenic sarcoma cells.
Osteosarcoma
MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation.
Osteosarcoma
Protein kinase C modulates parathyroid hormone- but not prostaglandin E2-mediated stimulation of cyclic AMP production via the inhibitory guanine nucleotide binding protein in UMR-106 osteosarcoma cells.
Osteosarcoma
Regulation of gene transcription and proliferation by parathyroid hormone is blocked in mutant osteoblastic cells resistant to cyclic AMP.
Osteosarcoma
Role of calcium/protein kinase C in the regulation of DNA synthesis by parathyroid hormone-related peptide in osteoblastic osteosarcoma cells.
Osteosarcoma
Selective hormonal activation of cyclic AMP-dependent protein kinase isoenzymes in normal and malignant osteoblasts.
Osteosarcoma
The activation of cAMP-dependent protein kinase is directly linked to homologous desensitization by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells.
Osteosarcoma
The direct involvement of cAMP-dependent protein kinase in the regulation of collagen synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblast-like osteosarcoma cells (UMR-106).
Osteosarcoma
The participation of the activation of cAMP-dependent protein kinase in cytosolic acidification by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells.
Otitis Media
A kinase inhibitor screen identifies signaling pathways regulating mucosal growth during otitis media.
Ovarian Neoplasms
Aurora A kinase regulates non-homologous end-joining and poly(ADP-ribose) polymerase function in ovarian carcinoma cells.
Ovarian Neoplasms
New benzimidazoles and their antitumor effects with Aurora A kinase and KSP inhibitory activities.
Ovarian Neoplasms
Phase II study of MLN8237 (alisertib), an investigational Aurora A kinase inhibitor, in patients with platinum-resistant or -refractory epithelial ovarian, fallopian tube, or primary peritoneal carcinoma.
Ovarian Neoplasms
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.
Ovarian Neoplasms
Regulatory subunits of PKA define an axis of cellular proliferation/ differentiation in ovarian cancer cells.
Ovarian Neoplasms
Targeting Aurora A Kinase (AAK) in Platinum-Resistant High Grade Serous Ovarian Cancer.
Pancreatic Cyst
Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct.
Pancreatic Neoplasms
Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer.
Pancreatic Neoplasms
Docking and three-dimensional quantitative structure-activity relationship analyses of imidazole and thiazolidine derivatives as Aurora A kinase inhibitors.
Pancreatic Neoplasms
EB1 phosphorylation mediates the functions of ASK1 in pancreatic cancer development.
Pancreatic Neoplasms
GSK3beta and beta-catenin modulate radiation cytotoxicity in pancreatic cancer.
Pancreatic Neoplasms
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.
Pancreatic Neoplasms
Pdx-1-driven overexpression of aurora a kinase induces mild ductal dysplasia of pancreatic ducts near islets in transgenic mice.
Pancreatic Neoplasms
RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.
Pancreatitis
Acute pancreatitis results in referred mechanical hypersensitivity and neuropeptide up-regulation that can be suppressed by the protein kinase inhibitor k252a.
Paralysis
Disruption of the A-kinase anchoring domain in flagellar radial spoke protein 3 results in unregulated axonemal cAMP-dependent protein kinase activity and abnormal flagellar motility.
Paraplegia
Molecular pathways of oligodendrocyte apoptosis revealed by mutations in the proteolipid protein gene.
Parasitic Diseases
A Schistosome cAMP-Dependent Protein Kinase Catalytic Subunit Is Essential for Parasite Viability.
Parathyroid Neoplasms
Phospholipid/Ca2+-dependent protein kinase activity in human parathyroid adenoma.
Parkinson Disease
Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila.
Parkinson Disease
Akt as a Victim, Villain and Potential Hero in Parkinson's Disease Pathophysiology and Treatment.
Parkinson Disease
Discovery of LRRK2 inhibitors by using an ensemble of virtual screening methods.
Parkinson Disease
DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage.
Parkinson Disease
Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.
Parkinson Disease
Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.
Parkinson Disease
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding.
Parkinson Disease
Measuring the activity of leucine-rich repeat kinase 2: a kinase involved in Parkinson's disease.
Parkinson Disease
Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease.
Parkinson Disease
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Parkinson Disease
Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations.
Parkinson Disease
Phosphorylation of p53 by LRRK2 induces microglial tumor necrosis factor ?-mediated neurotoxicity.
Parkinson Disease
Pink1 Forms a Multiprotein Complex with Miro and Milton, Linking Pink1 Function to Mitochondrial Trafficking (dagger).
Parkinson Disease
Regulation of a distinct activated RIPK1 intermediate bridging complex I and complex II in TNF?-mediated apoptosis.
Parkinson Disease
The neuroprotective effect of human uncoupling protein 2 (hUCP2) requires cAMP-dependent protein kinase in a toxin model of Parkinson's disease.
Parkinsonian Disorders
Cyclic AMP-dependent protein kinase activity in the human brain: values in Parkinsonism.
Pelizaeus-Merzbacher Disease
Molecular pathways of oligodendrocyte apoptosis revealed by mutations in the proteolipid protein gene.
Peripheral Vascular Diseases
Comparison of vasodilatory prostaglandins with respect to cAMP-mediated phosphorylation of a target substrate in intact human platelets.
Pheochromocytoma
Activation of rat pheochromocytoma tyrosine hydroxylase by a cyclic AMP-dependent protein kinase in a cell-free system.
Pheochromocytoma
Cyclic AMP induction of early adenovirus promoters involves sequences required for E1A trans-activation.
Pheochromocytoma
Enhanced phosphorylation of tyrosine hydroxylase at more than one site is induced by 56 mM K+ in rat pheochromocytoma PC12 cells in culture.
Pheochromocytoma
Identification of four phosphorylation sites in the N-terminal region of tyrosine hydroxylase.
Pheochromocytoma
Immunofluorescence localization of the regulatory subunit type II of cAMP-dependent protein kinase in PC12 and 3T3 cells in different proliferative states.
Pheochromocytoma
Induction of proto-oncogene fos transcription through the adenylate cyclase pathway: characterization of a cAMP-responsive element.
Pheochromocytoma
Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.
Pheochromocytoma
Phosphorylation of rat tyrosine hydroxylase and its model peptides in vitro by cyclic AMP-dependent protein kinase.
Pheochromocytoma
Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.
Pheochromocytoma
Phosphorylation of tyrosine hydroxylase by cyclic GMP-dependent protein kinase.
Pheochromocytoma
Rat pheochromocytoma tyrosine hydroxylase is phosphorylated on serine 40 by an associated protein kinase.
Pheochromocytoma
Regulation of human tyrosine hydroxylase activity. Effects of cyclic AMP-dependent protein kinase, calmodulin-dependent protein kinase II and polyanion.
Pheochromocytoma
Regulation of the activity of tyrosine hydroxylase in the central nervous system.
Pheochromocytoma
The activity of cAMP-dependent protein kinase is required at a posttranslational level for induction of voltage-dependent sodium channels by peptide growth factors in PC12 cells.
Pheochromocytoma
The cAMP-dependent protein kinase regulates transcription of the dopamine beta-hydroxylase gene.
Pheochromocytoma
The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells.
Pheochromocytoma
The cyclic adenosine monophosphate-dependent protein kinase (PKA) is required for the sustained activation of mitogen-activated kinases and gene expression by nerve growth factor.
Pheochromocytoma
Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells.
Pituitary Neoplasms
Activators of protein kinase C and cyclic AMP-dependent protein kinase regulate intracellular calcium levels through distinct mechanisms in mouse anterior pituitary tumor cells.
Pituitary Neoplasms
Chaperones, somatotroph tumors and the cyclic AMP (cAMP)-dependent protein kinase (PKA) pathway.
Pituitary Neoplasms
Constitutive somatostatin receptor subtype-3 signaling suppresses growth hormone synthesis.
Pituitary Neoplasms
Corticotropin-releasing factor-induced adrenocorticotropin hormone release and synthesis is blocked by incorporation of the inhibitor of cyclic AMP-dependent protein kinase into anterior pituitary tumor cells by liposomes.
Pituitary Neoplasms
Effect of cyclic adenosine 3',5'-monophosphate/protein kinase a pathway on markers of cell proliferation in nonfunctioning pituitary adenomas.
Pituitary Neoplasms
Hormonal activation of the cAMP-dependent protein kinases in AtT20 cells. Preferential activation of protein kinase I by corticotropin releasing factor, isoproterenol, and forskolin.
Pituitary Neoplasms
Increased activity of type I regulatory subunit of cyclic adenosine 3',5'-monophosphate-dependent protein kinase in estrogen-induced pituitary tumors.
Pituitary Neoplasms
Liposome delivery of cyclic AMP-dependent protein kinase inhibitor into intact cells: specific blockade of cyclic AMP-mediated adrenocorticotropin release from mouse anterior pituitary tumor cells.
Pituitary Neoplasms
Molecular genetics of the cAMP-dependent protein kinase pathway and of sporadic pituitary tumorigenesis.
Pituitary Neoplasms
Mutation analysis of protein kinase A catalytic subunit in thyroid adenomas and pituitary tumours.
Pituitary Neoplasms
Post-transcriptional regulation of cAMP-dependent protein kinase activity by cAMP in GH3 pituitary tumor cells. Evidence for increased degradation of catalytic subunit in the presence of cAMP.
Pituitary Neoplasms
Tamoxifen-induced growth arrest and apoptosis in pituitary tumor cells in vitro via a protein kinase C-independent pathway.
Plasmacytoma
Resolution and general properties of different types of ribosomal protein kinases in mouse plasmocytoma.
Pneumonia
Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and COVID-19.
Polycystic Kidney Diseases
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycystic Kidney Diseases
cAMP-dependent protein kinase and proliferation differ in normal and polycystic kidney epithelia.
Polycystic Kidney Diseases
Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones.
Polycystic Kidney, Autosomal Dominant
Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
Proliferative signaling by ERBB proteins and RAF/MEK/ERK effectors in polycystic kidney disease.
Polycystic Kidney, Autosomal Dominant
The Effect of cAMP-PKA Activation on TGF-?1-Induced Profibrotic Signaling.
Polycythemia Vera
Anti-inflammatory cytokines hepatocyte growth factor and interleukin-11 are over-expressed in Polycythemia vera and contribute to the growth of clonal erythroblasts independently of JAK2V617F.
Polycythemia Vera
The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.
Pre-Eclampsia
Downregulation of cAMP-Dependent Protein Kinase Inhibitor-b Promotes Preeclampsia by Decreasing Phosphorylated Akt.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Aurora A kinase as a target for therapy in TCF3-HLF rearranged acute lymphoblastic leukemia.
Primary Myelofibrosis
The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.
Prostatic Neoplasms
A Phase I/II Study of the Investigational Drug Alisertib in Combination With Abiraterone and Prednisone for Patients With Metastatic Castration-Resistant Prostate Cancer Progressing on Abiraterone.
Prostatic Neoplasms
Androgens regulate prostate cancer cell growth via an AMPK-PGC-1?-mediated metabolic switch.
Prostatic Neoplasms
Calcitonin increases invasiveness of prostate cancer cells: role for cyclic AMP-dependent protein kinase A in calcitonin action.
Prostatic Neoplasms
Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness.
Prostatic Neoplasms
Defining and Targeting the Oncogenic Drivers of Neuroendocrine Prostate Cancer.
Prostatic Neoplasms
Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A.
Prostatic Neoplasms
Enhanced inhibition of prostate tumor growth by dual targeting the androgen receptor and the regulatory subunit type i? of protein kinase a in vivo.
Prostatic Neoplasms
Extracellular catalytic subunit activity of the cAMP-dependent protein kinase in prostate cancer.
Prostatic Neoplasms
Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway.
Prostatic Neoplasms
Identification of human male germ cell-associated kinase, a kinase transcriptionally activated by androgen in prostate cancer cells.
Prostatic Neoplasms
Methionine restriction induces apoptosis of prostate cancer cells via the c-Jun N-terminal kinase-mediated signaling pathway.
Prostatic Neoplasms
Phosphorylation of the androgen receptor by PIM1 in hormone refractory prostate cancer.
Prostatic Neoplasms
Quantitative Assessment of AKAP12 Promoter Methylation in Human Prostate Cancer Using Methylation-sensitive High-resolution Melting: Correlation With Gleason Score.
Prostatic Neoplasms
Recepteur d'origine nantais (RON), more than a kinase: Role in castrate-resistant prostate cancer.
Prostatic Neoplasms
Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: Cross-talk with the androgen receptor.
Prostatic Neoplasms
Saracatinib as a metastasis inhibitor in metastatic castration-resistant prostate cancer: A University of Chicago Phase 2 Consortium and DOD/PCF Prostate Cancer Clinical Trials Consortium Study.
Prostatic Neoplasms
Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae.
Prostatic Neoplasms
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models.
protein acetyllysine n-acetyltransferase deficiency
Protective Effects of Oroxylin A against Doxorubicin-Induced Cardiotoxicity via the Activation of Sirt1 in Mice.
Pseudorabies
Ribofuranosyl-benzimidazole derivatives as inhibitors of casein kinase-2 and casein kinase-1.
Psoriasis
Oxidative modulation of cyclic AMP-dependent protein kinase in human fibroblasts: possible role in psoriasis.
Psoriasis
Post-translational abnormality of the type II cyclic AMP-dependent protein kinase in psoriasis: modulation by retinoic acid.
Psoriasis
Preferential inhibition of the mRNA expression of p38 MAPK regulated cytokines in psoriatic skin by anti-TNF? therapy.
Pulmonary Disease, Chronic Obstructive
Progress in the mechanism and targeted drug therapy for COPD.
Reperfusion Injury
Effect of sevoflurane on the ATPase activity of hippocampal neurons in a rat model of cerebral ischemia-reperfusion injury via the cAMP-PKA signaling pathway.
Reperfusion Injury
Implication of Protein Kinase A for a Hepato-Protective Mechanism of Milrinone Pretreatment.
Reperfusion Injury
Neuropeptide PACAP in mouse liver ischemia and reperfusion injury: immunomodulation via cAMP-PKA pathway.
Reperfusion Injury
Trapidil protects ischemic hearts from reperfusion injury by stimulating PKAII activity.
Retinoblastoma
Abnormal expression of the RI subunit of cyclic AMP-dependent protein kinase in Y-79 retinoblastoma cells.
Retinoblastoma
Cyclin-dependent kinase-like function is shared by the beta- and gamma- subset of the conserved herpesvirus protein kinases.
Retinoblastoma
Distribution of the regulatory subunit of type II cAMP-dependent protein kinase in Y-79 retinoblastoma cells. Effect of butyrate.
Retinoblastoma
IL-1 induces expression of p21(WAF1) independently of p53 in high-passage human embryonic fibroblasts WI38.
Retinoblastoma
Low doses of bisphenol A promote human seminoma cell proliferation by activating PKA and PKG via a membrane G-protein-coupled estrogen receptor.
Retinoblastoma
Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.
Rhabdomyosarcoma
Aurora A Kinase Inhibition Destabilizes PAX3-FOXO1 and MYCN and Synergizes with Navitoclax to Induce Rhabdomyosarcoma Cell Death.
Salmonella Infections
Multiple Host Kinases Contribute to Akt Activation during Salmonella Infection.
Sandhoff Disease
Prostaglandin E2 reverses aberrant production of an inflammatory chemokine by microglia from Sandhoff disease model mice through the cAMP-PKA pathway.
Sarcoma
A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Regorafenib Versus Placebo in Advanced/Metastatic, Treatment-Refractory Liposarcoma: Results from the SARC024 Study.
Sarcoma
Alternate protein kinase A activity identifies a unique population of stromal cells in adult bone.
Sarcoma
Development of novel, highly potent inhibitors of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF): increasing cellular potency through optimization of a distal heteroaromatic group.
Sarcoma
Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome.
Sarcoma
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.
Sarcoma, Avian
Comparison of cAMP-dependent protein kinase in normal and Rous sarcoma virus transformed chick embryo fibroblasts.
Sarcoma, Avian
Concerted regulation of steroidogenic acute regulatory gene expression by luteinizing hormone and insulin (or insulin-like growth factor I) in primary cultures of porcine granulosa-luteal cells.
Sarcoma, Avian
Cytosolic malic dehydrogenase activity is associated with a putative substrate for the transforming gene product of Rous sarcoma virus.
Sarcoma, Avian
Identification of a fish protein associated with a kinase activity and related to the Rous sarcoma virus transforming protein.
Sarcoma, Avian
Protein kinase and its regulatory effect on reverse transcriptase activity of Rous sarcoma virus.
Schistosomiasis
Conservation of protein kinase a catalytic subunit sequences in the schistosome pathogens of humans.
Seizures
Activation of death-associated protein kinase in human peritumoral tissue: A potential therapeutic target.
Seizures
Alcohol Withdrawal Increases Protein Kinase A Activity in the Rat Inferior Colliculus.
Seizures
Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex.
Seizures
Overexpressed HspB6 Underlines a Novel Inhibitory Role in Kainic Acid-Induced Epileptic Seizure in Rats by Activating the cAMP-PKA Pathway.
Sepsis
Differential activation of protein kinase A in various regions of myocardium during sepsis.
Sepsis
Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury.
Sepsis
Liver protein kinase A activity is decreased during the late hypoglycemic phase of sepsis.
Sepsis
Protection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of beta2-adrenoceptor.
Sepsis
Protein kinase a activity is increased in rat heart during late hypodynamic phase of sepsis.
Sepsis
[Impaired calcium uptake by cardiac sarcoplasmic reticulum and its underlying mechanism during rat septic shock]
Spinal Cord Injuries
Spinal activation of the cAMP-PKA pathway induces respiratory motor recovery following high cervical spinal cord injury.
Spinocerebellar Ataxias
Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.
Squamous Cell Carcinoma of Head and Neck
Combined Aurora kinase A (AURKA) and WEE1 inhibition demonstrates synergistic antitumor effect in squamous cell carcinoma of the head and neck.
Squamous Cell Carcinoma of Head and Neck
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.
Starvation
A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development.
Starvation
AKT Ser/Thr kinase increases V-ATPase-dependent lysosomal acidification in response to amino acid starvation in mammalian cells.
Starvation
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae.
Starvation
Coordination of cell decisions and promotion of phenotypic diversity in B. subtilis via pulsed behavior of the phosphorelay.
Starvation
Crosstalk between cAMP-PKA and MAP kinase pathways is a key regulatory design necessary to regulate FLO11 expression.
Starvation
Interaction between the tRNA-Binding and C-Terminal Domains of Yeast Gcn2 Regulates Kinase Activity In Vivo.
Starvation
Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans.
Starvation
Modulation of expression of the stress-inducible p118 of Saccharomyces cerevisiae by cAMP. II. A study of p118 expression in mutants of the cAMP cascade.
Starvation
Phosphorylation of the protein kinase A catalytic subunit is induced by cyclic AMP deficiency and physiological stresses in the fission yeast, Schizosaccharomyces pombe.
Starvation
RAM pathway contributes to Rpb4 dependent pseudohyphal differentiation in Saccharomyces cerevisiae.
Starvation
Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase.
Starvation
Starvation promotes Dictyostelium development by relieving PufA inhibition of PKA translation through the YakA kinase pathway.
Starvation
The lag phase rather than the exponential-growth phase on glucose is associated with a higher cAMP level in wild-type and cAPK-attenuated strains of the yeast Saccharomyces cerevisiae.
Starvation
The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle.
Starvation
The wis1 signal transduction pathway is required for expression of cAMP-repressed genes in fission yeast.
Stomach Neoplasms
Identification of kinases and kinase inhibitors for the differential targeting of Wnt/?-catenin signaling in gastric cancer subtypes.
Stomach Neoplasms
[Regulation of traditional Chinese medicine formulae bailong on cAMP-PKA and DAG-PKC signal pathways of human gastric cancer cells]
Telangiectasis
ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels.
Telangiectasis
Microcephalin: a causal link between impaired damage response signalling and microcephaly.
Telangiectasis
N-hydroxycinnamide derivatives of osthole inhibit cell migration and invasion by suppressing Smad2 and Akt pathways in human colorectal adenocarcinoma cells.
Telangiectasis
Threonine-11, phosphorylated by Rad3 and atm in vitro, is required for activation of fission yeast checkpoint kinase Cds1.
Teratocarcinoma
Regulation of the laminin beta 1 (LAMB1), retinoic acid receptor beta, and bone morphogenetic protein 2 genes in mutant F9 teratocarcinoma cell lines partially deficient in cyclic AMP-dependent protein kinase activity.
Teratocarcinoma
Retinoic acid-induced rapid loss of nuclear cyclic AMP-dependent protein kinase in teratocarcinoma cells.
Thrombocythemia, Essential
The diagnosis and management of polycythemia vera, essential thrombocythemia, and primary myelofibrosis in the JAK2 V617F era.
Thrombosis
Differential Role of PKA Catalytic Subunits in Mediating Phenotypes Caused by Knockout of the Carney Complex Gene Prkar1a.
Thymoma
Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa.
Thyroid Cancer, Papillary
Growth regulation of the human papillary thyroid cancer cell line by protein tyrosine kinase and cAMP-dependent protein kinase.
Thyroid Cancer, Papillary
Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain.
Thyroid Neoplasms
Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles.
Thyroid Neoplasms
c-Myc is a major determinant for antitumor activity of Aurora A kinase inhibitor MLN8237 in thyroid cancer.
Thyroid Neoplasms
Cyclic AMP inhibits the proliferation of thyroid carcinoma cell lines through regulation of CDK4 phosphorylation.
Thyroid Neoplasms
Identification of two novel RET kinase inhibitors through MCR-based drug discovery: design, synthesis and evaluation.
Triple Negative Breast Neoplasms
A kinase inhibitor screen identifies a dual cdc7/CDK9 inhibitor to sensitise triple-negative breast cancer to EGFR-targeted therapy.
Triple Negative Breast Neoplasms
Aurora A kinase activates YAP signaling in triple-negative breast cancer.
Triple Negative Breast Neoplasms
Preclinical and Dose-Finding Phase I Trial Results of Combined Treatment with a TORC1/2 Inhibitor (TAK-228) and Aurora A Kinase Inhibitor (Alisertib) in Solid Tumors.
Triple Negative Breast Neoplasms
Suppression of TRPM7 enhances TRAIL-induced apoptosis in triple-negative breast cancer cells.
Triple Negative Breast Neoplasms
WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance.
Tuberculosis
Elevated cyclic AMP Inhibits Mycobacterium tuberculosis-stimulated T cell IFN-? Secretion through type I Protein Kinase A.
Tuberous Sclerosis
Early activation of mTORC1 in response to mechanical overload is independent of PI3K/Akt signaling.
Tuberous Sclerosis
Rationally Designed 3D Hydrogels Model Invasive Lung Diseases Enabling High-Content Drug Screening.
Tuberous Sclerosis
Tricornered Kinase Regulates Synapse Development by Regulating the Levels of Wiskott-Aldrich Syndrome Protein.
Urinary Bladder Neoplasms
Aurora A Kinase as a diagnostic urinary marker for urothelial bladder cancer.
Urinary Bladder Neoplasms
MicroRNA-124-3p affects proliferation, migration and apoptosis of bladder cancer cells through targeting AURKA.
Uterine Cervical Neoplasms
Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237.
Uterine Cervical Neoplasms
Expression of Aurora kinase A and B in normal and malignant cervical tissue: high Aurora A kinase expression in squamous cervical cancer.
Vascular Diseases
Inhibition of vascular smooth muscle cell migration by cytochrome p450 epoxygenase-derived eicosanoids.
Vascular System Injuries
Activation of cAMP-PKA signaling in vivo inhibits smooth muscle cell proliferation induced by vascular injury.
Vascular System Injuries
Analysis of Genes Related to Angiotensin II-Induced Arterial Injury Using a Time Series Microarray.
Vascular System Injuries
Membrane-bound protein kinase A inhibits smooth muscle cell proliferation in vitro and in vivo by amplifying cAMP-protein kinase A signals.
Vasospasm, Intracranial
Thin and thick filament regulation of contractility in experimental cerebral vasospasm.
Vesicular Stomatitis
Inhibitory effect of glycyrrhizin on polypeptide phosphorylation by polypeptide-dependent protein kinase (kinase P) in vitro.
Vesicular Stomatitis
Macropinocytosis contributes to hantavirus entry into human airway epithelial cells.
Virus Diseases
Activation of the mitogen-activated protein kinase p38 by human cytomegalovirus infection through two distinct pathways: a novel mechanism for activation of p38.
Virus Diseases
Frog virus 3-mediated translational shut-off: frog virus 3 messages are translationally more efficient than host and heterologous viral messages under conditions of increased translational stress.
Virus Diseases
Polarized Trout Epithelial Cells Regulate Transepithelial Electrical Resistance, Gene Expression, and the Phosphoproteome in Response to Viral Infection.
Virus Diseases
Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi.
Vitamin D Deficiency
Cyclic AMP dependent protein kinase and its endogenous inhibitor protein: tissue distribution and effect of vitamin D status in the chick.
Vitamin D Deficiency
Effect of vitamin D status on cyclic AMP-dependent protein kinase activity and its heat-stable inhibitor in chick kidney.
Vitamin D Deficiency
Effect of vitamin D status on the activity of carbonic anhydrase in chicken epiphysis and kidney.
Warts
Binary regulation of Hippo pathway by Merlin/NF2, Kibra, Lgl, and Melted specifies and maintains postmitotic neuronal fate.
Warts
Combined functional genomic and proteomic approaches identify a PP2A complex as a negative regulator of Hippo signaling.
Warts
Homeodomain-interacting protein kinase regulates yorkie activity to promote tissue growth.
Warts
Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.
Warts
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila.
Warts
The Hippo/STE20 homolog SIK1 interacts with MOB1 to regulate cell proliferation and cell expansion in Arabidopsis.
Whooping Cough
17?-estradiol potentiates TREK1 channel activity through G protein-coupled estrogen receptor.
Whooping Cough
Activation of a muscarinic receptor selectively inhibits a rapidly inactivated Ca2+ current in rat sympathetic neurons.
Whooping Cough
Activation of metabotropic glutamate receptors by L-AP4 stimulates survival of rat cerebellar granule cells in culture.
Whooping Cough
Alternate coupling of receptors to Gs and Gi in pancreatic and submandibular gland cells.
Whooping Cough
ATP produces potassium currents via P3 purinoceptor in the follicle cell layer of Xenopus oocytes.
Whooping Cough
beta 2-adrenergic receptor activates extracellular signal-regulated kinases (ERKs) via the small G protein rap1 and the serine/threonine kinase B-Raf.
Whooping Cough
Biochemical investigation of cell motile activity in rheumatoid synovial fluid.
Whooping Cough
Differential calcium regulation of proinflammatory activities in human neutrophils exposed to the neuropeptide pituitary adenylate cyclase-activating protein.
Whooping Cough
Effects of phosphorylation of inhibitory GTP-binding protein by cyclic AMP-dependent protein kinase on its ADP-ribosylation by pertussis toxin, islet-activating protein.
Whooping Cough
Extracellular signal-regulated kinase 1/2 control Ca(2+)-independent force development in histamine-stimulated bovine tracheal smooth muscle.
Whooping Cough
Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes.
Whooping Cough
Involvement of cAMP-dependent protein kinase and pertussis toxin-sensitive G-proteins in CGRP mediated JNK activation in human neuroblastoma cell line.
Whooping Cough
Isolation and structural characterisation of a novel 13-amino acid insulin-releasing peptide from the skin secretion of Agalychnis calcarifer.
Whooping Cough
Mechanisms and modulation of pituitary adenylate cyclase-activating protein-induced calcium mobilization in human neutrophils.
Whooping Cough
N-methyl D-aspartate receptor-mediated bidirectional control of extracellular signal-regulated kinase activity in cortical neuronal cultures.
Whooping Cough
Nefiracetam modulates acetylcholine receptor currents via two different signal transduction pathways.
Whooping Cough
Neural effects of parathyroid hormone: modulation of the calcium channel current and metabolism of monoamines in identified Helisoma snail neurons.
Whooping Cough
Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.
Whooping Cough
Regulation by chronic clonidine of adenylate cyclase and cyclic AMP-dependent protein kinase in the rat locus coeruleus.
Whooping Cough
Regulation of cytosolic calcium by cAMP and cGMP in freshly isolated smooth muscle cells from bovine trachea.
Whooping Cough
Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma.
Whooping Cough
SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway.
Whooping Cough
Structural insight into the role of the PAS domainfor signal transduction in sensor-kinase BvgS.
Whooping Cough
The action of 5-HT on calcium-dependent potassium channels and on the spinal locomotor network in lamprey is mediated by 5-HT1A-like receptors.
Whooping Cough
Thrombin activation of the Na+/H+ exchanger in vascular smooth muscle cells. Evidence for a kinase C-independent pathway which is Ca2+-dependent and pertussis toxin-sensitive.
Wilms Tumor
Distribution and properties of type I and type II binding proteins in the cyclic adenosine 3':5'-monophosphate-dependent protein kinase system in Wilms' tumor.
X-Linked Combined Immunodeficiency Diseases
Dysfunctional cytokine receptor signaling in severe combined immunodeficiency.
Yellow Fever
The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with Mg2+ and beta,gamma-methyleneadenosine 5'-triphosphate, sitting drop vapor diffusion method, using 100 mM MES (pH 6.5), 5 mM dithiothreitol, and 15-20% (w/v) PEG 4000 at 4-14°C
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Gerlits, O.; Waltman, M.J.; Taylor, S.; Langan, P.; Kovalevsky, A.
Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase: an X-ray crystallographic study of complexes with various metals and peptide substrate SP20
Biochemistry
52
3721-3727
2013
Homo sapiens (P61925)
brenda
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Release 2023.1 (January 2023)
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