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Information on EC 2.7.10.2 - non-specific protein-tyrosine kinase and Organism(s) Xenopus laevis and UniProt Accession P12965
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2.7.10.2 non-specific protein-tyrosine kinaseIUBMB Comments
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families .
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Word Map
- 2.7.10.2
- leukemia
- imatinib
- lymphocytic
- integrins
-
myelogenous
- metastasis
- t-cells
-
cytogenetic
-
philadelphia
- mapks
- lymphoma
- sh2
- cytoskeleton
- erk
- phosphatidylinositol
- lymphoblastic
- adhesions
-
signal-regulated
-
myeloproliferative
- 3-kinase
- autophosphorylation
- paxillin
- dasatinib
- hematologic
- collagen
-
stats
-
remiss
- arthritis
- fibronectin
- neoplasm
-
relapse
-
tyrosine-phosphorylated
- oncoproteins
-
platelet-derived
- pkc
- phosphotyrosine
-
rheumatoid
-
dominant-negative
- adaptor
- mesylate
-
allogeneic
- factor-beta
-
breakpoints
-
integrin-mediated
- cd4
- crisis
- c-kit
-
activins
- drug development
- synthesis
- medicine
- analysis
- pharmacology
- pdgfr
-
kinase-dependent
The taxonomic range for the selected organisms is: Xenopus laevis
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Synonyms
bcr-abl, focal adhesion kinase, c-abl, zap-70, src kinase, janus kinase, v-src, ephb4, p56lck, bruton's tyrosine kinase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
70 kDa zeta-associated protein
-
-
-
-
ACTR-IIB
-
-
-
-
ACTRIIA
-
-
-
-
Agammaglobulinaemia tyrosine kinase
-
-
-
-
Amylovoran biosynthesis membrane-associated protein amsA
-
-
-
-
ATK
-
-
-
-
B cell progenitor kinase
-
-
-
-
B lymphocyte kinase
-
-
-
-
B-cell/myeloid kinase
-
-
-
-
BCR-ABL tyrosine kinase
-
-
-
-
BMK
-
-
-
-
BMP type II receptor
-
-
-
-
BMP-2/BMP-4 receptor
-
-
-
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Bone marrow kinase BMX
-
-
-
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BPK
-
-
-
-
Breast tumor kinase
-
-
-
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Bruton's tyrosine kinase
-
-
-
-
c-ABL
-
-
-
-
c-FER
-
-
-
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C-FES
-
-
-
-
C-SRC
-
-
-
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C-SRC kinase
-
-
-
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C-YES
-
-
-
-
CADTK
-
-
-
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CAK beta
-
-
-
-
Calcium-dependent tyrosine kinase
-
-
-
-
Cell adhesion kinase beta
-
-
-
-
D-ash
-
-
-
-
DFer
-
-
-
-
Dsrc28C
-
-
-
-
ectoprotein kinase
-
-
-
-
Epithelial and endothelial tyrosine kinase
-
-
-
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EPS I polysaccharide export protein epsB
-
-
-
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focal adhesion kinase 1
-
-
-
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gene lck protein kinase
-
-
-
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gene lck tyrosine kinase
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-
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Hematopoietic consensus tyrosine-lacking kinase
-
-
-
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Hemopoietic cell kinase
-
-
-
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IL-2-inducible T-cell kinase
-
-
-
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Itk
-
-
-
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JAK protein tyrosine kinase
-
-
-
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Kinase EMB
-
-
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Kinase EMT
-
-
-
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Kinase TLK
-
-
-
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kinase, protein (phosphorylating tyrosine)
-
-
-
-
kinase, protein p56lck (phosphorylating)
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-
-
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L-JAK
-
-
-
-
Lck Tyrosine kinase
-
-
-
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Leukocyte janus kinase
-
-
-
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LSK
-
-
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nonreceptor protein tyrosine kinase
-
-
-
-
NTK38
-
-
-
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Nuclear tyrosine protein kinase RAK
-
-
-
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ORF6
-
-
-
-
p150
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-
-
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p55-BLK
-
-
-
-
P55-FGR
-
-
-
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p56-HCK
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-
-
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p56-HCK/p59-HCK
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-
-
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P56-LCK
-
-
-
-
p56lck kinase
-
-
-
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p56lck protein kinase
-
-
-
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p56lck protein tyrosine kinase
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-
-
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p56lck tyrosine kinase
-
-
-
-
P57-STK
-
-
-
-
P59-FYN
-
-
-
-
p59-HCK/p60-HCK
-
-
-
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P60-SRC
-
-
-
-
p60-YRK
-
-
-
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P61-YES
-
-
-
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p94-FER
-
-
-
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phosphotyrosyl-protein kinase
-
-
-
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PP125FAK
-
-
-
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Protein kinase (tyrosine-phosphorylating)
-
-
-
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protein kinase A
-
-
-
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Protein kinase BATK
-
-
-
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Protein kinase HYL
-
-
-
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Protein kinase Lck
-
-
-
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Protein kinase NTK
-
-
-
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Protein kinase p56-LCK
-
-
-
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Protein kinase p56lck
-
-
-
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Protein p56c-lck kinase
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-
-
-
Protein p56lck tyrosine kinase
-
-
-
-
Protein tyrosine kinase
-
-
-
-
protein tyrosine kinase 2beta
-
-
-
-
Protein tyrosine kinase lck
-
-
-
-
Protein tyrosine kinase p56lck
-
-
-
-
Protein tyrosine kinase pp56lck
-
-
-
-
Protein-tyrosine kinase C-TKL
-
-
-
-
Protein-tyrosine kinase CYL
-
-
-
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PTK
-
-
-
-
PTK-RL-18
-
-
-
-
PTK70
-
-
-
-
Quek1
-
-
-
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Related adhesion focal tyrosine kinase
-
-
-
-
Resting lymphocyte kinase
-
-
-
-
Rlk/Txk
-
-
-
-
S-domain receptor-like protein kinase
-
-
-
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SLK
-
-
-
-
Spleen tyrosine kinase
-
-
-
-
src-kinase
-
-
-
-
SRC-related intestinal kinase
-
-
-
-
Syk-related tyrosine kinase
-
-
-
-
SYN
-
-
-
-
T cell-specific protein-tyrosine kinase
-
-
-
-
T-cell-specific kinase
-
-
-
-
Tyrosine kinase
-
-
-
-
Tyrosine kinase ARG
-
-
-
-
Tyrosine kinase lck
-
-
-
-
Tyrosine kinase p56lck
-
-
-
-
Tyrosine phosphokinase
-
-
-
-
Tyrosine protein kinase
-
-
-
-
Tyrosine protein kinase p56lck
-
-
-
-
Tyrosine-protein kinase brk
-
-
-
-
Tyrosine-protein kinase CTK
-
-
-
-
Tyrosine-protein kinase Lyk
-
-
-
-
Tyrosine-protein kinase TYRO 10
-
-
-
-
Tyrosine-specific protein kinase
-
-
-
-
Tyrosylprotein kinase
-
-
-
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v-fps Protein-tyrosine kinase
-
-
-
-
WEE1hu
-
-
-
-
YES related kinase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
phospho group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
ATP:[protein]-L-tyrosine O-phosphotransferase (non-specific)
Unlike EC 2.7.10.1, receptor protein-tyrosine kinase, this protein-tyrosine kinase does not have a transmembrane domain. In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into ten families [1].
CAS REGISTRY NUMBER
COMMENTARY
114051-78-4
p56lck protein kinase
80449-02-1
protein-tyrosine kinase
9026-43-1
this CAS Reg. No. encompasses a great variety of protein kinases including the serine/threonine specific kinases
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + cdc2
ADP + phosphorylated cdc2
phosphorylated exclusively on Y15
-
?
additional information
?
-
functions during reinitiation of meiotic division
-
-
?
additional information
?
-
the kinase induces progression through the cell cycle for both meiotic and mitotic cells
-
-
?
additional information
?
-
is likely to participate in a variety of integrin-extracellular-matrix-dependent signaling events during morphogenesis
-
-
?
additional information
?
-
-
is likely to participate in a variety of integrin-extracellular-matrix-dependent signaling events during morphogenesis
-
-
?
additional information
?
-
participate in signalling pathways activated in response to cell interaction, role for FAK in gastrulation
-
-
?
additional information
?
-
-
participate in signalling pathways activated in response to cell interaction, role for FAK in gastrulation
-
-
?
additional information
?
-
yes gene product is likely to play an important role in oogenesis or early development
-
-
?
additional information
?
-
importance of the function of activin receptor in the regulatory mechanism for body axis formation
-
-
?
additional information
?
-
down-regulation of Wee1-like kinase activity by phosphorylation at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
additional information
?
-
functions during reinitiation of meiotic division
-
-
?
additional information
?
-
the kinase induces progression through the cell cycle for both meiotic and mitotic cells
-
-
?
additional information
?
-
is likely to participate in a variety of integrin-extracellular-matrix-dependent signaling events during morphogenesis
-
-
?
additional information
?
-
-
is likely to participate in a variety of integrin-extracellular-matrix-dependent signaling events during morphogenesis
-
-
?
additional information
?
-
participate in signalling pathways activated in response to cell interaction, role for FAK in gastrulation
-
-
?
additional information
?
-
-
participate in signalling pathways activated in response to cell interaction, role for FAK in gastrulation
-
-
?
additional information
?
-
yes gene product is likely to play an important role in oogenesis or early development
-
-
?
additional information
?
-
importance of the function of activin receptor in the regulatory mechanism for body axis formation
-
-
?
additional information
?
-
down-regulation of Wee1-like kinase activity by phosphorylation at mitosis is a multistep process that occurs after other biochemical reactions have signaled the successful completion of S phase
-
-
?
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
the c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation
additional information
additional information
during gastrulation, FAK protein expression increases significantly and is detected in mesoderm, marginal zone ectoderm, and cells of the blastocoel roof
additional information
-
during gastrulation, FAK protein expression increases significantly and is detected in mesoderm, marginal zone ectoderm, and cells of the blastocoel roof
additional information
maternal FAK transcript is present in Xl eggs, with levels decreasing slightly through cleavage and early blastula stages. At early gastrulation, the FAK mRNA level becomes modestly elevated, followed by a steady decline through late gastrulation. The mRNA level undergoes a further drop at the neurula stage, then begins a steady increase through the tailbud and tadpole stages
additional information
-
maternal FAK transcript is present in Xl eggs, with levels decreasing slightly through cleavage and early blastula stages. At early gastrulation, the FAK mRNA level becomes modestly elevated, followed by a steady decline through late gastrulation. The mRNA level undergoes a further drop at the neurula stage, then begins a steady increase through the tailbud and tadpole stages
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
isolation of cDNA
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Steele, R.E.; Irwin, M.Y.; Knudsen, C.L.; Collett, J.W.; Fero, J.B.
The yes proto-oncogene is present in amphibians and contributes to the maternal RNA pool in the oocyte
Oncogene Res.
4
223-233
1989
Xenopus laevis (P10936)
Steele, R.E.; Unger, T.F.; Mardis, M.J.; Fero, J.B.
The two Xenopus laevis SRC genes are co-expressed and each produces functional pp60src
J. Biol. Chem.
264
10649-10653
1989
Xenopus laevis (P13115), Xenopus laevis (P13116)
Steele, R.E.
Two divergent cellular src genes are expressed in Xenopus laevis
Nucleic Acids Res.
13
1747-1761
1985
Xenopus laevis (P13116)
Steele, R.E.; Deng, J.C.; Ghosn, C.R.; Fero, J.B.
Structure and expression of fyn genes in Xenopus laevis
Oncogene
5
369-376
1990
Xenopus laevis (P13406)
Zhang, X.; Wright, C.V.; Hanks, S.K.
Cloning of a Xenopus laevis cDNA encoding focal adhesion kinase (FAK) and expression during early development
Gene
160
219-222
1995
Xenopus laevis (Q91738), Xenopus laevis
Hens, M.D.; DeSimone, D.W.
Molecular analysis and developmental expression of the focal adhesion kinase pp125FAK in Xenopus laevis
Dev. Biol.
170
274-288
1995
Xenopus laevis (Q91738), Xenopus laevis
Mathews, L.S.; Vale, W.W.; Kintner, C.R.
Cloning of a second type of activin receptor and functional characterization in Xenopus embryos
Science
255
1702-1705
1992
Xenopus laevis (P27041)
Kondo, M.; Tashiro, K.; Fujii, G.; Asano, M.; Miyoshi, R.; Yamada, R.; Muramatsu, M.; Shiokawa, K.
Activin receptor mRNA is expressed early in Xenopus embryogenesis and the level of the expression affects the body axis formation
Biochem. Biophys. Res. Commun.
181
684-690
1991
Xenopus laevis (P27039)
Freeman, R.S.; Pickham, K.M.; Kanki, J.P.; Lee, B.A.; Pena, S.V.; Donoghue, D.J.
Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes
Proc. Natl. Acad. Sci. USA
86
5805-5809
1989
Xenopus laevis (P12965)
Sagata, N.; Oskarsson, M.; Copeland, T.; Brumbaugh, J.; Vande Woude, G.F.
Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes
Nature
335
519-525
1988
Xenopus laevis (P12965)
Le Guellec, R.; Couturier, A.; Le Guellec, K.; Paris, J.; Le Fur, N.; Philippe, M.
Xenopus c-raf proto-oncogene: cloning and expression during oogenesis and early development
Biol. Cell.
72
39-45
1991
Xenopus laevis (P09560)
Le Guellec, R.; Le Guellec, K.; Paris, J.; Philippe, M.
Nucleotide sequence of Xenopus C-raf coding region
Nucleic Acids Res.
16
10357
1988
Xenopus laevis (P09560)
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