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Information on EC 2.6.1.45 - serine-glyoxylate transaminase
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2.6.1.45 serine-glyoxylate transaminaseIUBMB Comments
A pyridoxal-phosphate protein.
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Word Map
- 2.6.1.45
- hyperoxaluria
- peroxisomal
- oxalate
- pyridoxal
- hydroxypyruvate
-
liver-specific
-
mistargeting
- pyridoxine
-
photorespiration
-
photorespiratory
- oxalosis
-
2.6.1.44
-
glutamate:glyoxylate
- hyphomicrobium
- urolithiasis
- nephrocalcinosis
- methylovorum
-
peroxisome-to-mitochondrion
-
intraperoxisomal
-
liver-kidney
-
anlage
-
plp-dependent
- agriculture
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
alanine:glyoxylate aminotransferase, sgat, serine-glyoxylate aminotransferase, serine:glyoxylate aminotransferase, l-serine:glyoxylate aminotransferase, serine-glyoxylate transaminase, l-serine glyoxylate aminotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
alanine:glyoxylate aminotransferase
-
the human liver enzyme has also serine:glyoxylate aminotransferase activity
aminotransferase, serine-glyoxylate
-
-
-
-
L-serine glyoxylate aminotransferase
-
-
-
-
serine-alpha-ketoglutarate aminotransferase
serine-glyoxylate aminotranferase
serine-glyoxylate aminotransferase
serine:glyoxylate aminotransferase
Sga
Sga20Z
SGAT
SKAT
additional information
serine-glyoxylate aminotransferase
-
-
-
-
additional information
see also EC 2.6.1.51 and 2.6.1.44
-
additional information
see also EC 2.6.1.51 and 2.6.1.44
-
additional information
see also EC 2.6.1.44 and EC 2.6.1.51
additional information
see also EC 2.6.1.44 and EC 2.6.1.51
-
additional information
Methylotuvimicrobium alcaliphilum DSM 19304
see also EC 2.6.1.44 and EC 2.6.1.51
-
additional information
Methylotuvimicrobium alcaliphilum NCIMB 14124
see also EC 2.6.1.44 and EC 2.6.1.51
-
additional information
Methylotuvimicrobium alcaliphilum VKM B-2133
see also EC 2.6.1.44 and EC 2.6.1.51
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-serine + glyoxylate = 3-hydroxypyruvate + glycine
ping-pong reaction mechanism
-
L-serine + glyoxylate = 3-hydroxypyruvate + glycine
ping-pong reaction mechanism
-
L-serine + glyoxylate = 3-hydroxypyruvate + glycine
ping-pong reaction mechanism
-
L-serine + glyoxylate = 3-hydroxypyruvate + glycine
ping pong bi bi mechanism
-
L-serine + glyoxylate = 3-hydroxypyruvate + glycine
reaction is catalyzed via the initial formation of an external Schiff base intermediate
-
L-serine + glyoxylate = 3-hydroxypyruvate + glycine
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amino group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
L-serine:glyoxylate aminotransferase
A pyridoxal-phosphate protein.
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CAS REGISTRY NUMBER
COMMENTARY
37259-57-7
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-alanine + 2-oxomalonate
pyruvate + 2-aminomalonate
-
-
-
?
L-asparagine + hydroxypyruvate
2-oxosuccinamate + L-serine
-
20% of L-serine transamination activity
-
?
L-serine + 2-oxosuccinamate
3-hydroxypyruvate + L-asparagine
-
poor substrate
-
?
L-serine + 3-hydroxypyruvate
3-hydroxypyruvate + L-serine
-
-
-
?
L-serine + hydroxypyruvate
3-hydroxypyruvate + L-serine
-
poor substrate
-
?
L-alanine + glyoxylate
pyruvate + glycine
55% of the activity with L-serine and glyoxylate
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
Methylotuvimicrobium alcaliphilum DSM 19304
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
Methylotuvimicrobium alcaliphilum NCIMB 14124
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
Methylotuvimicrobium alcaliphilum VKM B-2133
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
-
20% of L-serine transamination activity
-
?
L-asparagine + glyoxylate
2-oxosuccinamate + glycine
-
transamination at 38% the rate of L-serine
-
r
L-asparagine + glyoxylate
2-oxosuccinamate + glycine
-
20% of L-serine transamination actiivty
-
r
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
Methylotuvimicrobium alcaliphilum DSM 19304
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
Methylotuvimicrobium alcaliphilum NCIMB 14124
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
Methylotuvimicrobium alcaliphilum VKM B-2133
-
-
-
?
L-serine + 2-oxomalonate
3-hydroxypyruvate + 2-aminomalonate
-
-
-
?
L-serine + 2-oxomalonate
3-hydroxypyruvate + 2-aminomalonate
-
-
-
?
L-serine + 2-oxomalonate
3-hydroxypyruvate + 2-aminomalonate
-
-
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
reaction in photorespiratory glycolate pathway
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
reduced activity in vivo results in the accumulation of serine and to a smaller extend, of glycine, indicating that the flux through the photorespiratory pathway is restricted
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
-
-
ir
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
highly specific
-
ir
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
no activity with Phe, Arg, Val, Trp, Thr, Met
-
ir
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
nearly irreversible, trace amounts of L-serine
-
ir
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
no activity with D-serine
-
ir
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
no or trace activity with oxaloacetate, 2-oxoglutarate
-
ir
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
no activity with Ala, Glu, Gln, His, oxamate, 2-oxo-n-butanoate, 3-methyl-2-oxo-butanoate, 2-methyl-DL-serine, L-serine-O-sulfate, DL-serine hydroxamate, O-phospho-L-serine
-
ir
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
plays essential role in methanol assimilation through serine pathway
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
part of the C-1 assimilation pathway
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
Methylorubrum extorquens ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1
-
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
Methylotuvimicrobium alcaliphilum DSM 19304
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
Methylotuvimicrobium alcaliphilum NCIMB 14124
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
Methylotuvimicrobium alcaliphilum VKM B-2133
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
reverse reaction at 4-11% the rate of forward reaction
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
preferred substrates
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
preferred substrates
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
involved in glycine metabolism
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
no activity with Phe, Arg, Val, Trp, Thr, Met
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
reverse reaction at 4-11% the rate of forward reaction
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
preferred substrates
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
no or trace activity with oxaloacetate, 2-oxoglutarate
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
no activity with Tyr, Ile, Pro, Cys, Leu, Asp
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
equilibrium towards glycine production
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
reverse reaction at 4-11% the rate of forward reaction
-
r
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
physiologically irreversible
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
Methylotuvimicrobium alcaliphilum DSM 19304
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
Methylotuvimicrobium alcaliphilum NCIMB 14124
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
Methylotuvimicrobium alcaliphilum VKM B-2133
reaction of serine-pyruvate aminotransferase (SPAT), EC 2.6.1.51
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
-
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
6% of glyoxylate transamination activity
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
8% of glyoxylate transamination activity
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
equilibrium towards alanine production
-
r
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
8% of glyoxylate transamination activity
-
?
L-serine + pyruvate
3-hydroxypyruvate + L-alanine
-
poor substrate, 10% of glyoxylate transamination activity
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-serine + 3-hydroxypyruvate
3-hydroxypyruvate + L-serine
-
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
Methylotuvimicrobium alcaliphilum DSM 19304
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
Methylotuvimicrobium alcaliphilum NCIMB 14124
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-alanine + glyoxylate
pyruvate + glycine
Methylotuvimicrobium alcaliphilum VKM B-2133
reaction of alanine-glyoxylate aminotransferase (AGAT), EC 2.6.1.44
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
Methylotuvimicrobium alcaliphilum DSM 19304
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
Methylotuvimicrobium alcaliphilum NCIMB 14124
-
-
-
?
L-serine + 2-oxoglutarate
3-hydroxypyruvate + L-glutamate
Methylotuvimicrobium alcaliphilum VKM B-2133
-
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
reaction in photorespiratory glycolate pathway
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
reduced activity in vivo results in the accumulation of serine and to a smaller extend, of glycine, indicating that the flux through the photorespiratory pathway is restricted
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
plays essential role in methanol assimilation through serine pathway
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
part of the C-1 assimilation pathway
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
-
preferred substrates
-
-
?
L-serine + glyoxylate
3-hydroxypyruvate + glycine
preferred substrates
-
-
?