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Information on EC 2.4.99.8 - alpha-N-acetylneuraminate alpha-2,8-sialyltransferase

for references in articles please use BRENDA:EC2.4.99.8
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IUBMB Comments
Gangliosides act as acceptors.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
alpha-2,8-polysialyltransferase, alpha-2,8-PST, alpha-2,8-sialyltransferase, alpha-2,8-sialyltransferase 8A, alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1, alpha2,8-sialyltransferase, alpha2,8S-T, CMP-N-acetylneuraminate: N-acetyl-neuraminyl-D-galactosyl-D-glucosylceramide N-acetylneuraminyl alpha2->8 transferase, CMP-NAcNeu:GM3 ganglioside sialyltransferase, CMP-NeuAc:GD3(alpha 2-8) sialyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R
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