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Information on EC 2.4.2.46 - galactan 5-O-arabinofuranosyltransferase and Organism(s) Corynebacterium glutamicum and UniProt Accession Q8NTW4

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EC Tree
     2 Transferases
         2.4 Glycosyltransferases
             2.4.2 Pentosyltransferases
                2.4.2.46 galactan 5-O-arabinofuranosyltransferase
IUBMB Comments
Isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum. These arabinofuranosyl groups form the start of an arabinofuranan chain as part of the of the cell wall in mycobacteria.
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This record set is specific for:
Corynebacterium glutamicum
UNIPROT: Q8NTW4
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Word Map
The taxonomic range for the selected organisms is: Corynebacterium glutamicum
The enzyme appears in selected viruses and cellular organisms
Synonyms
arabinofuranosyltransferase, rv3792, araft, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
arabinofuranosyltransferase
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AftA
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alpha(1->5) AraT
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alpha1(1->5) arabinofuranosyltransferase
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Rv3792
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
galactofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 5-O-alpha-D-arabinofuranosyltransferase
Isolated from Mycobacterium tuberculosis and Corynebacterium glutamicum. These arabinofuranosyl groups form the start of an arabinofuranan chain as part of the of the cell wall in mycobacteria.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
alpha-D-Araf(1->3)-alpha-D-Araf-O-(CH2)7CH3 + decaprenyl phosphoryl-D-arabinose
?
show the reaction diagram
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the enzyme adds an alpha-D-Araf(1->5) to the 3-arm of the acceptor
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-
?
alpha-D-Araf(1->3)-alpha-D-Araf-O-(CH2)7CH3 + decaprenyl phosphoryl-D-arabinose
alpha-D-Araf(1->5)-alpha-D-Araf(1 ->3)-alpha-D-Araf-O-(CH2)7CH3 + ?
show the reaction diagram
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?
alpha-D-Araf(1->5)-alpha-D-Araf-O-(CH2)7CH3 + decaprenyl phosphoryl-D-arabinose
?
show the reaction diagram
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the enzyme adds an alpha-D-Araf(1->5) to the 3-arm of the acceptor
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?
additional information
?
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the enzyme catalyzes the addition of the first three arabinose units onto the galactan chain and associates with other arabinofuranosyltransferases, including Emb and AftC, that elongate and branch the arabinan domain
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?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
additional information
?
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the enzyme catalyzes the addition of the first three arabinose units onto the galactan chain and associates with other arabinofuranosyltransferases, including Emb and AftC, that elongate and branch the arabinan domain
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
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the enzyme is involved in the biosynthesis of the mycobacterial cell wall core
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli XL-1 Blue cells
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jankute, M.; Byng, C.V.; Alderwick, L.J.; Besra, G.S.
Elucidation of a protein-protein interaction network involved in Corynebacterium glutamicum cell wall biosynthesis as determined by bacterial two-hybrid analysis
Glycoconj. J.
31
475-483
2014
Corynebacterium glutamicum (Q8NTW4)
Manually annotated by BRENDA team
Alderwick, L.; Birch, H.; Krumbach, K.; Bott, M.; Eggeling, L.; Besra, G.
AftD functions as an alpha1->5 arabinofuranosyltransferase involved in the biosynthesis of the mycobacterial cell wall core
Cell Surf.
1
2-14
2018
Corynebacterium glutamicum
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Manually annotated by BRENDA team