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UDP-N-acetyl-alpha-D-glucosamine + pancreatic ribonuclease A
UDP + pancreatic ribonuclease A with N-acetylglucosamine linked to Asp
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UDP-N-acetyl-D-glucosamine + protein
UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein
UDP-N-acetylglucosamine + pancreatic ribonuclease A
UDP + pancreatic ribonuclease A with N-acetylglucosamine linked to Asp-34
additional information
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catalyses the glycosylation in vitro of the asparagine residue present in the sequence Asn, Leu, Thr
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UDP-N-acetyl-D-glucosamine + protein

UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein
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UDP-N-acetyl-D-glucosamine + protein
UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein
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?
UDP-N-acetyl-D-glucosamine + protein
UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein
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?
UDP-N-acetylglucosamine + pancreatic ribonuclease A

UDP + pancreatic ribonuclease A with N-acetylglucosamine linked to Asp-34
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?
UDP-N-acetylglucosamine + pancreatic ribonuclease A
UDP + pancreatic ribonuclease A with N-acetylglucosamine linked to Asp-34
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?
UDP-N-acetylglucosamine + pancreatic ribonuclease A
UDP + pancreatic ribonuclease A with N-acetylglucosamine linked to Asp-34
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?
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Alzheimer Disease
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability.
Alzheimer Disease
[Effects of Xixin decoction on enzymes related to O-GlcNAc glycosylation of tau proteins in the brain of rats with sporadic Alzheimer's disease].
Aortic Valve Stenosis
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.
Breast Neoplasms
mTOR/MYC Axis Regulates O-GlcNAc Transferase (OGT) Expression and O-GlcNAcylation in Breast Cancer.
Breast Neoplasms
Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.
Breast Neoplasms
O-GlcNAcylation of cofilin promotes breast cancer cell invasion.
Breast Neoplasms
Proteomic analysis of O-GlcNAcylated proteins in invasive ductal breast carcinomas with and without lymph node metastasis.
Carcinogenesis
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Carcinogenesis
Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.
Carcinoma
Critical role of O-GlcNAc transferase in prostate cancer invasion, angiogenesis and metastasis.
Carcinoma, Hepatocellular
MicroRNA-24-1 suppresses mouse hepatoma cell invasion and metastasis via directly targeting O-GlcNAc transferase.
Cardiovascular Diseases
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability.
Cardiovascular Diseases
The role of O-GlcNAc transferase in regulating the gene transcription of developing and failing hearts.
Cholangiocarcinoma
Overexpression of O-GlcNAc-Transferase Associates with Aggressiveness of Mass-Forming Cholangiocarcinoma.
Colorectal Neoplasms
Alteration of O-GlcNAcylation affects serine phosphorylation and regulates gene expression and activity of pyruvate kinase M2 in colorectal cancer cells.
Diabetes Mellitus, Type 2
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability.
Diabetes Mellitus, Type 2
UDP-N-acetylglucosamine transferase and glutamine: fructose 6-phosphate amidotransferase activities in insulin-sensitive tissues.
Diabetic Cardiomyopathies
Impact of Type 2 diabetes and aging on cardiomyocyte function and O-linked N-acetylglucosamine levels in the heart.
Familial Primary Pulmonary Hypertension
O-GlcNAc Transferase Directs Cell Proliferation in Idiopathic Pulmonary Arterial Hypertension.
Heart Failure
The role of O-GlcNAc transferase in regulating the gene transcription of developing and failing hearts.
Hyperglycemia
Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation.
Hypertension
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.
Hypertension
O-GlcNAc Transferase Directs Cell Proliferation in Idiopathic Pulmonary Arterial Hypertension.
Insulin Resistance
Altered glycan-dependent signaling induces insulin resistance and hyperleptinemia.
Insulin Resistance
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance.
Insulin Resistance
Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity.
Intellectual Disability
Identification and Characterization of a Missense Mutation in the O-GlcNAc Transferase Gene that Segregates with X-Linked Intellectual Disability.
Intellectual Disability
The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix.
Leukemia
Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7).
Liver Neoplasms
O-GlcNAc transferase promotes fatty liver-associated liver cancer through inducing palmitic acid and activating endoplasmic reticulum stress.
Lung Neoplasms
Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.
Melanoma, Experimental
Augmented TME O-GlcNAcylation Promotes Tumor Proliferation through the Inhibition of p38 MAPK.
Myocardial Infarction
Cardiac O-GlcNAc signaling is increased in hypertrophy and heart failure.
Neoplasm Metastasis
Critical role of O-GlcNAc transferase in prostate cancer invasion, angiogenesis and metastasis.
Neoplasm Metastasis
MicroRNA-24-1 suppresses mouse hepatoma cell invasion and metastasis via directly targeting O-GlcNAc transferase.
Neoplasm Metastasis
O-GlcNAcylation of cofilin promotes breast cancer cell invasion.
Neoplasm Metastasis
Proteomic analysis of O-GlcNAcylated proteins in invasive ductal breast carcinomas with and without lymph node metastasis.
Neoplasms
Augmented TME O-GlcNAcylation Promotes Tumor Proliferation through the Inhibition of p38 MAPK.
Neoplasms
Bitterness in sugar: O-GlcNAcylation aggravates pre-B acute lymphocytic leukemia through glycolysis via the PI3K/Akt/c-Myc pathway.
Neoplasms
MAPK/ERK signaling pathway-induced hyper-O-GlcNAcylation enhances cancer malignancy.
Neoplasms
mTOR/MYC Axis Regulates O-GlcNAc Transferase (OGT) Expression and O-GlcNAcylation in Breast Cancer.
Neoplasms
Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation.
Neoplasms
O-GlcNAc transferase: a sweet new cancer target.
Neoplasms
O-GlcNAcase is essential for embryonic development and maintenance of genomic stability.
Neoplasms
O-GlcNAcylation and the Metabolic Shift in High-Proliferating Cells: All the Evidence Suggests that Sugars Dictate the Flux of Lipid Biogenesis in Tumor Processes.
Neoplasms
O-GlcNAcylation of fumarase maintains tumour growth under glucose deficiency.
Neoplasms
O-GlcNAcylation regulates cancer metabolism and survival stress signaling via regulation of the HIF-1 pathway.
Neoplasms
OGA heterozygosity suppresses intestinal tumorigenesis in Apc(min/+) mice.
Neoplasms
Silencing the Nucleocytoplasmic O-GlcNAc Transferase Reduces Proliferation, Adhesion, and Migration of Cancer and Fetal Human Colon Cell Lines.
Neoplasms
Single Quantum Dot-Based Nanosensor for Sensitive Detection of O-GlcNAc Transferase Activity.
Neoplasms
Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma.
Nervous System Diseases
Does O-GlcNAc play a role in neurodegenerative diseases?
Neurodegenerative Diseases
A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout.
Neurodegenerative Diseases
O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.
Neurodegenerative Diseases
Single Quantum Dot-Based Nanosensor for Sensitive Detection of O-GlcNAc Transferase Activity.
Prostatic Neoplasms
Critical role of O-GlcNAc transferase in prostate cancer invasion, angiogenesis and metastasis.
Prostatic Neoplasms
Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism.
Prostatic Neoplasms
O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells.
Sarcoma, Ewing
Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects.
Starvation
O-GlcNAc modification is essential for the regulation of autophagy in Drosophila melanogaster.
Uterine Cervical Neoplasms
O-linked GlcNAcylation elevated by HPV E6 mediates viral oncogenesis.
Virus Diseases
Identification of secret agent as the O-GlcNAc transferase that participates in Plum pox virus infection.
Walker-Warburg Syndrome
GTDC2 modifies O-mannosylated ?-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody.
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