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Information on EC 2.4.1.324 - 7-deoxyloganetin glucosyltransferase
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EC Tree
2.4.1.324 7-deoxyloganetin glucosyltransferaseIUBMB Comments
Isolated from the plants Catharanthus roseus (Madagascar periwinkle) and Gardenia jasminoides (cape jasmine). With Gardenia it also acts on genipin. Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetate. cf. EC 2.4.1.323 7-deoxyloganetic acid glucosyltransferase.
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The enzyme appears in viruses and cellular organisms
Synonyms
uridine diphosphate glycosyltransferase, ugt85a24, ugt94f2, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
UGT6
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
UDP-alpha-D-glucose + 7-deoxyloganetin = UDP + 7-deoxyloganin
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
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SYSTEMATIC NAME
IUBMB Comments
UDP-alpha-D-glucose:7-deoxyloganetin O-D-glucosyltransferase
Isolated from the plants Catharanthus roseus (Madagascar periwinkle) and Gardenia jasminoides (cape jasmine). With Gardenia it also acts on genipin. Involved in loganin and secologanin biosynthesis. Does not react with 7-deoxyloganetate. cf. EC 2.4.1.323 7-deoxyloganetic acid glucosyltransferase.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucose + 7-deoxyloganetin
UDP + 7-deoxyloganin
strict substrate specificity toward 7-deoxyloganetin
-
-
?
UDP-alpha-D-glucose + 7-deoxyloganetin
UDP + 7-deoxyloganin
the enzyme is involved in loganin and secologanin biosynthesis
-
-
?
UDP-alpha-D-glucose + 7-deoxyloganetin
UDP + 7-deoxyloganin
does not react with 7-deoxyloganetate, weak activity toward loganetin. The enzyme exhibits no activity toward either UDP-galactose or UDP-glucuronic acid
i.e. 7-deoxyloganetin 1-O-beta-D-glucoside
-
?
UDP-alpha-D-glucose + 7-deoxyloganetin
UDP + 7-deoxyloganin
-
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
UDP-alpha-D-glucose + 7-deoxyloganetin
UDP + 7-deoxyloganin
the enzyme is involved in loganin and secologanin biosynthesis
-
-
?
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Colorectal Neoplasms
Cost effectiveness of pharmacogenetic testing for uridine diphosphate glucuronosyltransferase 1A1 before irinotecan administration for metastatic colorectal cancer.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
the mRNA level gradually increases during the early stage of fruit ripening, whereas it remains low in the mature fruits
brenda
additional information
additional information
very low expression level in the stem
brenda
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). UGT6_CATRO
487
0
54611
Swiss-Prot
other Location (Reliability: 2)
UGT2_GARJA
481
0
53592
Swiss-Prot
other Location (Reliability: 2)
A0A2P6S0Z4_ROSCH
484
0
53735
TrEMBL
other Location (Reliability: 5)
A0A2G9FXZ1_9LAMI
486
0
54334
TrEMBL
other Location (Reliability: 5)
A0A2G9HLU9_9LAMI
410
0
45638
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2P6S0U4_ROSCH
175
0
19852
TrEMBL
other Location (Reliability: 2)
A0A2P6S0V9_ROSCH
478
0
53485
TrEMBL
other Location (Reliability: 3)
A0A2G9GXC0_9LAMI
482
0
54512
TrEMBL
Mitochondrion (Reliability: 5)
A0A396GEJ8_MEDTR
137
0
15551
TrEMBL
other Location (Reliability: 2)
A0A396HFT7_MEDTR
650
0
73723
TrEMBL
Mitochondrion (Reliability: 3)
A0A396HA40_MEDTR
175
0
19980
TrEMBL
other Location (Reliability: 4)
A0A2P6S0W7_ROSCH
277
0
30796
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2G9I8W5_9LAMI
465
0
51995
TrEMBL
other Location (Reliability: 4)
A0A2P6S0X6_ROSCH
82
0
9308
TrEMBL
other Location (Reliability: 4)
A0A2P6QKE9_ROSCH
329
0
36748
TrEMBL
other Location (Reliability: 3)
A0A2G9GM22_9LAMI
190
0
21451
TrEMBL
Secretory Pathway (Reliability: 4)
A0A396H7R1_MEDTR
63
0
7401
TrEMBL
other Location (Reliability: 3)
A0A2P6S0U0_ROSCH
245
0
27915
TrEMBL
Mitochondrion (Reliability: 5)
A0A396HBW1_MEDTR
395
0
43943
TrEMBL
other Location (Reliability: 4)
A0A396HC40_MEDTR
231
1
25952
TrEMBL
Secretory Pathway (Reliability: 1)
A0A396HA25_MEDTR
314
0
35253
TrEMBL
Secretory Pathway (Reliability: 5)
G7KED7_MEDTR
450
0
51285
TrEMBL
other Location (Reliability: 2)
A0A072TGV4_MEDTR
282
0
32234
TrEMBL
Mitochondrion (Reliability: 5)
A0A2G9H513_9LAMI
402
1
45475
TrEMBL
Mitochondrion (Reliability: 3)
A0A2G9FWD5_9LAMI
456
0
51496
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2P6R4C2_ROSCH
489
0
54553
TrEMBL
other Location (Reliability: 5)
A0A2G9FWL1_9LAMI
361
0
41439
TrEMBL
Secretory Pathway (Reliability: 2)
A0A396HBX1_MEDTR
469
0
52760
TrEMBL
other Location (Reliability: 5)
A0A396HC01_MEDTR
733
0
82729
TrEMBL
Mitochondrion (Reliability: 5)
A0A2P6Q9I5_ROSCH
220
0
24819
TrEMBL
Chloroplast (Reliability: 4)
A0A2P6RQB3_ROSCH
351
0
40067
TrEMBL
other Location (Reliability: 3)
A0A2G9I225_9LAMI
471
0
52327
TrEMBL
other Location (Reliability: 5)
A0A2G9GRL8_9LAMI
55
0
6197
TrEMBL
other Location (Reliability: 2)
A0A2G9I8W6_9LAMI
461
0
51683
TrEMBL
Chloroplast (Reliability: 4)
A0A396HA88_MEDTR
477
0
53671
TrEMBL
other Location (Reliability: 2)
G7KBB5_MEDTR
480
0
53890
TrEMBL
other Location (Reliability: 3)
A0A396HC75_MEDTR
142
1
16013
TrEMBL
Secretory Pathway (Reliability: 1)
A0A396HE96_MEDTR
186
0
21366
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2G9FWE3_9LAMI
93
0
10889
TrEMBL
other Location (Reliability: 3)
A0A396HSE1_MEDTR
89
0
10465
TrEMBL
other Location (Reliability: 3)
A0A396I195_MEDTR
244
0
27908
TrEMBL
Chloroplast (Reliability: 5)
A0A396HS23_MEDTR
314
0
35267
TrEMBL
other Location (Reliability: 2)
A0A2P6S0V4_ROSCH
243
0
26782
TrEMBL
other Location (Reliability: 3)
A0A2P6RQB4_ROSCH
132
0
14507
TrEMBL
Mitochondrion (Reliability: 4)
A0A2G9FXD1_9LAMI
258
0
28602
TrEMBL
other Location (Reliability: 4)
A0A2G9H0E2_9LAMI
192
0
22236
TrEMBL
other Location (Reliability: 2)
A0A2G9H0E3_9LAMI
295
0
33859
TrEMBL
other Location (Reliability: 2)
A0A396HEA4_MEDTR
773
0
86694
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2P6S0W3_ROSCH
249
0
28159
TrEMBL
other Location (Reliability: 5)
A0A2G9G8A8_9LAMI
396
0
43996
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2P6QKF0_ROSCH
139
0
15900
TrEMBL
other Location (Reliability: 1)
A0A2G9GXE5_9LAMI
483
0
55079
TrEMBL
Mitochondrion (Reliability: 5)
A0A2G9GIF0_9LAMI
307
0
35253
TrEMBL
other Location (Reliability: 2)
G7KLW8_MEDTR
293
0
33293
TrEMBL
other Location (Reliability: 2)
G7KLV5_MEDTR
485
0
54807
TrEMBL
Mitochondrion (Reliability: 4)
A0A072U5K9_MEDTR
214
0
23856
TrEMBL
other Location (Reliability: 3)
A0A2P6S400_ROSCH
178
0
19607
TrEMBL
other Location (Reliability: 5)
A0A2P6PIT6_ROSCH
89
0
9749
TrEMBL
other Location (Reliability: 2)
A0A2G9GRI7_9LAMI
182
0
20363
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2G9G572_9LAMI
483
0
55034
TrEMBL
Mitochondrion (Reliability: 5)
A0A2G9FXK2_9LAMI
486
0
54336
TrEMBL
other Location (Reliability: 5)
A0A2P6S401_ROSCH
454
0
50762
TrEMBL
other Location (Reliability: 4)
A0A396HGX6_MEDTR
82
0
9658
TrEMBL
other Location (Reliability: 2)
A0A396GP58_MEDTR
368
0
41432
TrEMBL
other Location (Reliability: 5)
A0A396HA35_MEDTR
123
0
14510
TrEMBL
other Location (Reliability: 3)
A0A2P6S3Y7_ROSCH
62
0
7125
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2G9FXA8_9LAMI
481
0
54642
TrEMBL
Mitochondrion (Reliability: 5)
A0A396HEB4_MEDTR
61
0
6913
TrEMBL
other Location (Reliability: 3)
A0A396HZL0_MEDTR
174
0
19262
TrEMBL
other Location (Reliability: 2)
A0A396HFS6_MEDTR
303
0
34351
TrEMBL
other Location (Reliability: 4)
F8WKW5_GARJA
493
0
55083
TrEMBL
other Location (Reliability: 1)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
molecular modeling and ligand docking studies. The enzyme shows maximum binding affinity towards 7-deoxyloganetin. Apigenin, kaempferol and naringenin show very poor binding affinity towards the proteins acceptor site
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expression as N-terminal fusion proteins with a His6 tag in Escherichia coli strain JM109
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
expression is strongly induced by phytohormone treatments: 15fold increase in the expression after 24 h of methyl jasmonate application, 10fold after 12 h of treatment with salicylic acid
mRNA level is markedly increased by adding methyl jasmonate to the cell cultures and the pattern of up-regulation correlated well with the pattern of increased enzymatic activity
the mRNA level gradually increases during the early stage of fruit ripening
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Nagatoshi, M.; Terasaka, K.; Nagatsu, A.; Mizukami, H.
Iridoid-specific glucosyltransferase from Gardenia jasminoides
J. Biol. Chem.
286
32866-32874
2011
Gardenia jasminoides (F8WKW5), Gardenia jasminoides
brenda
Asada, K.; Salim, V.; Masada-Atsumi, S.; Edmunds, E.; Nagatoshi, M.; Terasaka, K.; Mizukami, H.; de Luca, V.
A 7-deoxyloganetic acid glucosyltransferase contributes a key step in secologanin biosynthesis in madagascar periwinkle
Plant Cell
25
4123-4134
2013
Catharanthus roseus (F8WLS6)
brenda
Bhat, W.W.; Dhar, N.; Razdan, S.; Rana, S.; Mehra, R.; Nargotra, A.; Dhar, R.S.; Ashraf, N.; Vishwakarma, R.; Lattoo, S.K.
Molecular characterization of UGT94F2 and UGT86C4, two glycosyltransferases from Picrorhiza kurrooa: comparative structural insight and evaluation of substrate recognition
PLoS ONE
8
e73804
2013
Picrorhiza kurrooa (L7QGZ9), Picrorhiza kurrooa
brenda
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