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Information on EC 1.8.4.B3 - thioredoxin-independent methionine sulfoxide reductases B and Organism(s) Homo sapiens and UniProt Accession Q8IXL7

for references in articles please use BRENDA:EC1.8.4.B3
preliminary BRENDA-supplied EC number
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This record set is specific for:
Homo sapiens
UNIPROT: Q8IXL7
The taxonomic range for the selected organisms is: Homo sapiens
The enzyme appears in selected viruses and cellular organisms
Synonyms
hMsrB2, hMsrB3, NtMsrB1, thioredoxin-independent methionine sulfoxide reductases B, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hMsrB2
277223
-
hMsrB3
284367
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
L-methionine (R)-S-sulfoxide + thionein
L-methionine + thionein disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide
show the reaction diagram
reduced thioredoxin is not an efficient reducing agent for hMsrB3. Less than 5% of the activity with dithiothreitol
-
-
?
L-methionine (R)-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + dithiothreitol
L-methionine + dithiothreitol disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thionein
L-methionine + thionein disulfide + H2O
show the reaction diagram
-
-
-
?
L-methionine (R)-S-sulfoxide + thioredoxin
L-methionine + thioredoxin disulfide + H2O
show the reaction diagram
reduced thioredoxin is not an efficient reducing agent for hMsrB2. Less than 5% of the activity with dithiothreitol
-
-
?
additional information
?
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
MSRB3_HUMAN
192
0
20702
Swiss-Prot
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sagher, D.; Brunell, D.; Hejtmancik, J.F.; Kantorow, M.; Brot, N.; Weissbach, H.
Thionein can serve as a reducing agent for the methionine sulfoxide reductases
Proc. Natl. Acad. Sci. USA
103
8656-8661
2006
Homo sapiens, Homo sapiens (Q8IXL7), Homo sapiens (Q9Y3D2)
Manually annotated by BRENDA team
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